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Supplementary Table 1. Differentially Expressed Transcripts Between Insulin Treated (T) and Insulin Deprived (D) Type 1 Diabetic Patients

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Supplementary Table 1. Differentially Expressed Transcripts Between Insulin Treated (T) and Insulin Deprived (D) Type 1 Diabetic Patients Table Legends: Supplementary Table 1. Differentially expressed transcripts between insulin treated (T) and insulin deprived (D) type 1 diabetic patients. P values were calculated using paired t-tests, and not adjusted for multiple comparison errors. Annotations for each transcript were provided by Affymetrix NetAffx Analysis Center. Supplementary Table 2. Differentially expressed mitochondrial genes between insulin treated (T) and insulin deprived (D) type 1 diabetic patients. This EXCEL file has multiple data sheets. The data sheet “MITO GENE” lists the 68 mitochondrial genes, which were grouped into 11 functional groups in 11 data sheets. P values were calculated using paired t-tests, and not adjusted for multiple comparison errors. Annotations for each transcript were provided by Affymetrix NetAffx Analysis Center. OXPHOS- oxidative phosphorylation; TCA - tricarboxylic acid cycle. Supplementary Table 3. Differentially expressed pathways by Ingenuity Pathway Analysis (IPA). This EXCEL file has two data sheets that listed the significantly up- and down-regulated pathways in insulin-deprived vs. insulin- treated patients, respectively. P values associated with each pathway were calculated by IPA. Genes were represented by HUGO symbols. Supplementary Table 1 probe set T1 T2 T3 T4 T5 T6 T7 T8 214046_at 71.6231 78.4793 69.0236 71.6228 71.3996 61.9447 66.1693 61.9322 240081_at 145.816 133.058 155.18 126.734 137.149 130.863 157.818 127.17 227644_at 132.603 132.984 144.789 127.445 134.055 115.207 141.926 126.212 233926_at 13.1944 14.7052 12.8407 17.9612 20.5816 21.2891 17.7716 19.2921 203900_at 113.539 110.389 116.157 123.636 109.456 120.694 136.221 141.172 240005_at 104.18 99.029 102.556 103.292 113.72 101.343 100.952 109.203 219674_s_ 213.709 245.661 224.924 216.232 197.479 178.472 161.245 183.982 208163_s_ 189.431 165.864 191.09 180.08 206.643 194.894 197.991 191.252 223999_at 108.548 94.3448 109.847 103.064 109.493 102.445 105.859 103.434 226729_at 136.196 142.109 154.438 145.668 163.991 149.435 164.251 151.957 237355_at 172.322 181.409 188.252 152.167 202.369 186.77 165.47 190.295 203176_s_ 184.774 237.473 194.103 220.764 195.596 210.557 193.794 238.674 213678_at 183.204 178.73 169.345 160.303 196.975 185.61 174.562 191.96 211592_s_ 180.121 170.147 207.013 153.487 198.602 184.428 197.474 170.539 202400_s_ 339.141 282.199 316.555 306.394 356.159 355.371 385.543 423.047 216557_x_ 116.31 107.042 107.678 96.4333 109.235 99.0346 104.39 93.1137 1554470_s 682.528 580.964 820.094 637.99 700.131 704.517 703.26 805.511 238797_at 94.219 72.2882 77.7071 84.195 90.8287 69.2672 77.1329 70.1294 243473_at 107.266 109.32 114.531 126.583 115.511 110.386 117.067 122.993 1555048_a 159.902 133.231 121.046 132.756 134.261 145.691 158.837 137.249 233268_s_ 1003.26 1282.11 1109.68 1124.67 1116.56 1120.3 1001.71 1174.74 1554235_a 29.5742 31.4312 41.7629 35.6667 36.04 39.7772 22.5037 31.2674 202857_at 663.362 697.742 582.362 607.92 635.548 604.674 634.915 633.469 1565849_a 353.531 291.661 330.808 334.725 323.914 356.149 388.458 344.145 223264_at 205.853 220.687 204.361 191.505 253.519 208.138 178.321 208.99 233371_at 144.99 136.397 149.226 119.371 150.932 148.048 145.22 142.039 202100_at 416.339 409.15 384.676 396.879 434.582 372.416 370.454 378.108 236867_at 216.737 218.711 226.034 192.639 226.701 219.258 233.487 211.691 240275_at 65.2385 65.4184 65.9767 65.3642 64.1741 76.9124 82.7221 78.761 230334_at 327.983 351.205 337.283 314.302 345.883 344.147 378.167 338.77 211905_s_ 103.344 87.9378 114.443 95.3616 100.32 86.6301 110.164 95.541 213050_at 372.547 348.876 353.071 384.72 407.605 396.811 496.582 371.784 228109_at 177.077 193.433 182.413 187.926 200.21 185.349 188.82 199.327 212360_at 183.143 181.801 190.196 215.774 207.712 190.516 200.376 221.106 215118_s_ 73.6616 80.4126 74.5545 65.9221 74.8326 53.4132 71.0354 62.2409 226278_at 234.075 273.808 226.121 197.1 234.384 206.124 221.32 229.6 227485_at 187.693 167.471 208.372 192.408 184.401 172.93 185.523 160.703 235222_x_ 230.725 237.321 246.859 245.533 243.524 238.347 243.16 237.361 213747_at 114.864 125.786 128.314 125.953 134.59 127.58 109.901 115.544 217555_at 356.851 381.665 367.227 319.28 375.9 358.343 300.781 354.538 1564160_a 34.4118 34.3093 21.5988 24.9987 29.5506 26.9158 24.3544 19.554 200974_at 1032.56 1115.84 1418.62 1325.59 1354.31 1457.09 1814.18 1350.77 212492_s_ 469.624 466.635 347.025 384.849 321.497 396.326 366.166 413.467 1566163_a 46.8407 44.0604 58.4003 42.7284 51.5333 40.909 42.4723 48.9468 1558722_a 86.5705 86.1568 97.5994 79.958 78.3789 113.749 84.4636 98.2049 217160_at 137.392 127.893 140.377 123.948 148.165 130.997 139.882 122.102 229193_at 95.6922 92.8051 83.5504 99.9889 106.076 92.43 102.536 99.0617 229765_at 63.1642 63.8632 49.6402 66.492 53.9389 47.0332 48.5757 50.8151 239897_at 281.403 261.542 301.286 290.505 253.371 264.076 340.579 309.84 1569341_a 76.8763 72.9679 78.4443 69.6564 72.6625 60.0157 68.4685 72.4005 228042_at 176.663 180.008 189.997 185.444 196.101 168.504 192.516 171.99 227606_s_ 110.376 97.4865 98.4015 92.9249 91.7825 113.233 114.683 92.7002 228340_at 115.852 107.663 125.753 111.877 117.617 99.786 117.615 100.288 224800_at 370.016 460.503 443.917 471.474 372.481 383.603 423.203 404.898 204260_at 92.9704 94.2702 107.284 97.6237 86.7177 96.2585 103.676 98.0154 222046_at 141.15 129.241 141.709 132.616 136.105 140.686 148.395 131.878 213867_x_ 3313.17 2897.28 3813.93 3880.54 4092.03 3294.86 4227.83 4716.53 227738_s_ 239.766 223.705 265.238 221.509 254.092 211.067 237.708 198.88 204728_s_ 35.8022 33.3791 27.6562 51.6139 42.8451 33.7239 33.0653 31.9961 213252_at 265.438 267.214 251.472 250.065 284.117 267.749 279.563 263.607 1559534_a 41.3217 44.9197 49.5092 44.519 40.614 32.8282 45.4931 33.5663 208443_x_ 56.0264 51.3488 61.3446 51.5051 57.9798 50.9163 59.6133 48.9198 236996_at 127.809 101.732 117.456 114.738 123.89 116.894 127.264 109.394 205956_x_ 300.231 252.94 274.167 277.028 264.695 323.696 409.503 335.219 1559936_a 129.808 115.435 136.496 112.324 123.598 104.734 105.316 108.921 237941_at 182.359 168.372 168.918 127.99 187.221 163.951 149.963 164.732 35671_at 748.887 732.048 793.666 764.347 907.6 910.472 1064.11 1010.76 230823_at 164.229 161.835 190.848 165.58 185.381 187.964 211.314 202.819 200801_x_ 3310.76 2842.31 3877.5 3891.52 4181.88 3316.81 4149.73 4691.63 227581_at 317.764 298.8 324.305 324.412 329.798 324.585 404.672 327.501 1557239_a 19.9656 20.9451 27.0169 23.1325 29.2567 19.868 22.9707 23.776 214858_at 80.3552 88.2488 86.512 79.5999 86.4318 84.6765 84.4436 76.9056 1558747_a 162.552 155.496 129.538 143.726 125.577 152.159 150.261 161.747 214409_at 54.15 56.8152 43.5476 55.1458 53.5537 46.753 58.8559 59.2569 230076_at 91.1782 83.8503 93.4151 87.7773 70.7695 79.1026 83.3633 83.5322 233289_at 46.6145 42.1749 46.8371 42.9368 45.0531 44.6453 38.9733 40.4024 213746_s_ 274.878 248.567 288.487 259.673 327.323 414 384.833 428.876 239898_x_ 393.892 355.29 362.383 397.462 358.396 377.772 434.607 389.861 227481_at 109.632 108.334 123.731 97.8815 104.453 110.861 115.545 108.786 217464_at 173.164 213.252 191.902 211.587 189.127 152.767 131.258 138.054 215505_s_ 146.014 147.017 150.59 159.37 146.578 143.914 198.492 186.044 212871_at 228.999 242.465 239.726 226.724 225.57 197.818 197.644 217.575 231008_at 109.426 105.418 112.771 101.955 110.287 102.502 120.926 99.9273 217182_at 175.412 163.189 173.4 141.352 176.794 162.055 155.751 159.834 1554577_a 530.31 450.407 519.367 533.346 491.614 379.741 437.396 390.333 237889_s_ 167.424 169.055 151.945 166.536 161.318 151.853 163.041 167.023 1570128_a 284.289 255.247 252.343 282.614 290.276 301.609 323.055 288.545 1557472_a 22.9502 20.9548 28.7857 18.6322 31.5425 18.5873 16.5081 23.1867 215418_at 146.942 153.283 137.898 156.652 166.62 136.427 137.791 134.825 223001_at 392.533 469.567 462.239 511.263 361.882 399.807 397.428 464.908 217150_s_ 264.03 269.26 235.121 249.637 273.373 271.72 266.716 299.431 223159_s_ 130.094 134.322 103.721 139.854 140.065 134.895 150.256 134.042 1558748_a 90.1661 104.558 80.535 86.6448 81.002 68.2254 76.5224 71.8129 235204_at 51.2018 52.3039 52.0759 37.1201 49.2144 48.3395 44.422 47.0356 239402_at 103.082 77.0117 89.5466 83.7368 78.4198 79.9127 93.4205 86.3832 241806_at 111.215 107.54 86.1918 95.8154 103.701 88.0306 96.0976 100.401 224594_x_ 3368.51 2916.4 3848.79 3876.89 4106.43 3337.75 4113.93 4551.17 242129_at 356.322 374.347 357.184 404.332 367.079 489.454 559.755 464.756 1567334_a 119.939 110.065 114.534 134.14 126.213 125.632 149.445 142.29 201772_at 291.31 408.675 467.833 546.931 327.383 463.261 412.697 590.303 203610_s_ 187.021 183.662 189.826 214.349 202.159 195.572 226.522 198.709 243030_at 158.61 135.59 180.315 137.536 162.937 144.546 152.454 142.086 214644_at 157.013 151.122 152.002 131.13 162.905 151.998 147.052 140.982 209196_at 216.983 176.952 206.329 204.033 211.021 191.332 190.442 197.114 201021_s_ 771.817 1014.21 931.256 1068.24 777.806 1037.91 791.157 892.422 241765_at 32.9635 34.3258 44.1116 34.0626 31.8393 23.0001 30.9691 20.7606 204140_at 265.367 234.415 234.976 249.374 258.294 238.414 237.535 258.835 204530_s_ 64.4555 68.9548 83.5519 66.2074 70.2812 59.6435 61.0225 54.4571 1563978_a 85.7361 91.0021 94.0758 91.2541 97.0442 92.7542 96.2874 92.7433 238925_at 127.988 115.175 142.859 123.259 122.271 122.001 157.23 134.326 239971_at 48.5606 42.1766 39.5288 39.3117 45.9811 46.8346 47.4388 40.1134 220544_at 125.367 113.309 135.716 121.595 129.327 115.492 131.122 123.766 1562747_a 80.2745 64.4711 69.1653 68.0333 66.777 81.8039 74.2713 73.3714 201261_x_ 247.556 261.725 275.39
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