St George Hospital | 2009 Research Report
The St George Medical Staff Council and St George Academic Schools, UNSW Introduction
As my colleagues were preparing this report I had the opportunity to reflect on the role of research in a modern teaching hospital. I realised that, looking back over my time in medicine, the best doctors I have ever known have been those actively involved in medical research. They were and are the ones who knew the most about medicine, the uncommon and rare diseases, the unusual presentations that can trick the unwary doctor as well as knowing the most modern treatments. They are the doctors least likely to prescribe unproven or incorrect treatments and the ones who question diagnoses based on inadequate evidence. I believe it is training in the scientific method of questioning and looking for evidence that has made my medical “heroes” into the doctors that they are.
To continue to strengthen the quality of medicine at St George Hospital, and thus produce more great doctors, it is essential that we support medical research at St George in all its forms – from pure bench research to applied clinical research and everything in between. The Medical Staff Council is very proud to support research at St George and grateful to the St George and Sutherland Medical Research Foundation for their support of our researchers.
A/Professor Allan Sturgess Chair, Medical Staff Council St George Hospital
Research in our teaching hospitals has long been a fundamental underpinning for the excellence in clinical care to which we all subscribe, and most would agree that this will not change in the future. St George has played an historically important role in pursuit of advances in basic and clinical sciences, while we have been less ready than many others to trumpet those achievements. This important report demonstrates the extraordinary breadth and impressive depth of research activities undertaken at St George. This is a document to be proud of, to work over coming years to improve on, and to use widely and loudly to push our case for just recognition of our contributions. It incorporates the efforts of hospital and UNSW staff across a range of disciplines and Schools. Read it, and be impressed. We owe a debt of gratitude to the few who have done most to bring this report to fruition.
Professor Michael Grimm Clinical Associate Dean St George Clinical School, UNSW
1 Research activity is a key focus in St George Hospital, which Women’s and Children’s Health has been pursuing increasingly in the last decade. I commend the Medical Staff Council and the Clinical School for their efforts in producing this Research Report. I am sure this will stimulate our young doctors, midwives and scientists to increase their research endeavours, and to have greater awareness of their colleagues’ interests and collaborative opportunities.
Professor Michael Chapman Head, Clinical School Women’s and Children’s Health UNSW
2 CONTENTS
Clinical Groups – St George Hospital
1. Medicine & Critical Care
Cardiology...... 5 Dermatology...... 6 Emergency Medicine...... 15 Endocrinology & Metabolism...... 18 Gastroenterology & Hepatology...... 22 Infectious Diseases, Immunology & Sexual Health...... 31 Intensive Care Medicine...... 38 Nuclear Medicine...... 46 Neurology...... 47 Renal Medicine...... 48 Respiratory Medicine & Sleep Disorders...... 54 Rheumatology...... 56
2. Surgery, Perioperative Care & Cancer
Surgery: Cardiothoracic...... 66 Gastrointestinal:...... 68 - Upper GI...... 68 - Liver (see UNSW Surgery)...... 70 - Colo-rectal...... 70 Neurosurgery...... 72 Orthopaedics...... 74 UNSW Surgery, Liver and Peritonectomy Unit...... 81 Vascular...... 88
Perioperative: Anaesthetics...... 89 Trauma...... 92 Pain Service...... 96
3 Cancer Care: Haematology...... 97 Medical Oncology...... 102 Radiation Oncology...... 106 Palliative Care...... 115 Oncology Clinical Trials Unit...... 118
3. Women’s and Children’s Health
Women’s Health...... 129 Urogynaecology...... 135 Paediatrics...... 140
4. Aged and Community Services
Aged Care...... 143 Rehabilitation...... 145
5. Allied Health Services
Nutrition & Dietetics...... 147
4 MEDICINE & CRITICAL CARE
DEPARTMENT OF CARDIOLOGY
1. Departmental Staff
Senior medical staff Senior Staff Specialists Dr Andrew Hopkins MBBS (Hons) DDU FRACP Dr David Ramsay MBBS FRACP Dr David Rees MBBS (Hons) PhD FRACP Conjoint Snr Lect UNSW Dr Mark Sader MBBS (Hons) PhD FRACP Conjoint Snr Lect UNSW
Staff Specialists Dr Mauritz Binnekamp BSc (Med) MBBS FRACP Dr Eugene Loh BSc MBBS FRACP Conjoint Lect UNSW Dr Ananth Prasan B Med Sci (Hons) MBBS MRCP PhD FRACP Conjoint Snr Lect UNSW Dr George Youssef BSc (Med) MBBS (Hons) FRACP Conjoint Lect UNSW
Advanced Trainees Rotational appointments between POW, SGH, TSH & Port Macquarie
Research Staff Nursing research staff - Kate Dobinson, Helen Goldsmith
2. Presentations at Scientific Meeetings/Conferences
A. French, J. Weaver, D. Ramsay, M. Binnekamp, D. Rees, A. Prasan, J. McCrohon. Evaluation of Myocardial Salvage and Intramyocardial Haemorrhage on T2 Weighted Cardiac Magnetic Resonance Imaging after Reperfused STEMI. Heart, Lung and Circulation 2009; 18 (Suppl 3): S41
5 DEPARTMENT OF DERMATOLOGY
1. Departmental Staff
Head of Department Dedee F Murrell MA(Cambridge) BM BCh (Oxford) FAAD (USA) MD (UNSW) FACD Conjoint Professor, Faculty of Medicine UNSW
Senior medical staff Visiting Medical Officers Anthony J Cronin MBBS (Syd) PhD (Cambridge) FACD Mei-Heng Tan MBBS (Syd) FAAD (USA) Lizbeth Ruth A. Intong MD FPDS (Honorary VMO)
Dept Administrative Assistant: Glendi McNab
Research Staff Senior research staff Lizbeth Ruth A Intong MD FPDS Post dermatology research fellow
Junior research staff Supriya Venugopal MBBS Predermatology research fellow
Research students Wenfei Yan MD China PhD student Supriya Venugopal MBBS Part-time PhD student Heather Cohn Postdoc student Ann-Marie Hanna, Minhee Kim, Niccolo Muller ILP students
Research Nurse Lesley M Rhodes RN
2. Research Grants
National, peer reviewed: NRISS Grant: 2008-2010 $99,000 Allogeneic cultured fibroblast trial in recessive dystrophic EB. Marian Sturm, Dedee Murrell Cell and Tissue Therapies, Royal Perth Hospital
6 Other Funding DebRA Australia $10,000 towards National EB Registry (2009)
Channel 7 Fund for Children’s Hospitals, Investigation of Fli-1 in wound healing, Allison Cowin, Ruth Arkell, Dedee Murrell. $45,000 (2008-2009)
University Post-graduate Awards for PhD students Wenfei Yan and Supriya Venugopal
3. Research Projects in Progress
RCT of allogeneic fibroblast cell therapy for recessive dystrophic EB (Murrell PI); Supriya Venugopal; Hellen Yan; Lesley Rhodes; John Frew; Heather Cohn)
Epidemiology and outcomes of squamous cell carcinoma in EB (Dedee Murrell, Minhee Kim, Supriya Venugopal)
Genetic modifiers of risk for squamous cell carcinoma in EB (Murrell DF, Cohn H)
Development of a quality of life instrument for autoimmune blistering diseases, the ABQOL (Dedee Murrell, Ann-Marie Hanna, Deshan Sebaratnam, Shienning Chee, Supriya Venugopal)
International validation of the QOLEB, the qualify of life measure we developed and published for Australian patients with EB (Dedee Murrell, John Frew)
RCT of Recell vs punch grafting for chronic stable vitiligo (Murrell, Venugopal, Linda Martin, John Le Guay, Richard Wittal, Lesley Rhodes)
Australasian EB Registry (Murrell, Rhodes)
Outcomes of pregnancies in EB (Murrell, Intong LRA, Choi DS, Rhodes LM, Chapman M)
Trial of gentian violet for Junctional EB (Murrell, Venugopal)
Response of multiple recalcitrant verrucae to gardasil vaccine (Murrell, Venugopal) Role of flightless -1 in EB and EBA (Kopecki, Murrell, Cowin)
7 4. Original Peer-Reviewed Publications (authors in Bold are at St George Hospital)
Frew JW, Martin LK, Nijsten T, Murrell DF Development of a quality of life index for epidermolysis bullosa (EB) through the development of the QOLEB questionnaire, an EB-specific quality of life instrument. Br J Dermatol 2009;161(6): 1323-30.
Shipman AR, Ali L, Murrell DF, Wojnarowska F. Mucous Membrane Pemphigoid: are Laminin 5 Antibodies a Risk Factor for Laryngeal Involvement? J Eur Acad Dermatol Venereol 2009; 23(2): 169-70.
Martin LK, Agero ALC, Werth V, Villanueva E, Segall J, Murrell DF Interventions for Pemphigus Vulgaris and Pemphigus Foliaceus. The Cochrane Database of Systematic Reviews, Review. 2009; 21(1): CD006263
Rosenbach M, Murrell DF, Bystryn J-C, Delay S, Dick S, Fakharzadeh S, Hall R, Korman NJ, Lin J, Okawa J, Pandya AG, Payne AS, Rose M, Rubenstein D, Woodley D, Vittoria C, Werth BB, Williams EA, Taylor L, Troxel A, Werth VP Comparison of reliability and validity between two outcome instruments for pemphigus. J Invest Dermatol 2009; 109: 2404-2410, 2009 Featured on front cover of journal as ‘outcome instruments for pemphigus’ with two other papers; accompanying commentary on ‘How to validate instruments for pemphigus’ by S. Bastuji-Garin and E Sbidian, JID p2328-9.
Vestergaard ME, Kossard S, Murrell DF Seborrheic keratoses appearing in sites of previous psoriasis plaques during responsive treatment with efalizumab. Clin Exp Dermatol 2009. 34 (8): e564-566.
Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, Murrell DF, Tang ML. Probiotics for treating eczema. Clin Exp Allergy 2009; 39(8):1117-1127.
Nading MA, Lahmar JJ, Frew JW, Ghionis N, Hanly M, Kemble-Welch A, Murrell DF A ski and adventure camp for young patients with severe forms of epidermolysis bullosa. J Am Acad Dermatol 2009; 61(3) 508-511
Foley P, Freeman M, Menter A, Siller G, El-Azhary RA, Gebauer K, Lowe NJ, Jarratt MJ, Murrell DF, Rich P, Pariser DM, Oseroff AR, Barnetson R, Anderson C, Kossard S. Gibson LE, Tope WD Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies. Int J Dermatol 2009; 48: 1236-1245
Foley P, Freeman M, Gebauer K, Murrell DF, Shumack S, Tyson C, Varigos G. Long- term efalizumab therapy for patients with moderate-to-severe, chronic plaque psoriasis: results from an Australian Expanded Access Programme. Int J Dermatol 2009; 48 (12): 1376-1384.
8 Venugopal SS, Murrell DF Seasonal onychomadesis in an elderly gentleman. Dermatology Reports 2009; Issue 1, Vol 1: e3.
5. Other published material
Sebaratnam DS, Murrell DF Management of Pemphigus. Expert Review of Dermatology, Future Science Group, London, 2009
Sebaratnam D, Murrell DF What’s New in the Management of Autoimmune Blistering Diseases. Access Dermatology, Prous Science, 2009.
Sebaratnam D, Murrell DF Treatment of Pemphigus vulgaris and pemphigus foliaceus. Expert Review of Dermatology, 2009; 4(5) 469-481.
Burgraaff K, Murrell DF: Jogger’s nipples. Medical Observer Jan 2009
Piels M, Murrell DF: Perioral dermatitis. Medical Observer Feb 20, 2009
Surjana D, Venugopal S, Murrell DF. A linear eruption. Medical Observer Mar 13, 2009 p 31.
Kopecki Z, Murrell DF, Cowin AJ (2009) Raising the roof on Epidermolysis Bullosa. Wound Practice & Research 17: 72-80, 2009.
Cohn HI, Murrell DF: Puzzling persistent papules: Darier disease. Medical Observer April 17th 2009, p. 32.
Mather-Hillon J, Ho SJ, Murrell DF: Purpura in a patient receiving heparin: HITTS. Medical Observer, May 2009.
Sonnergren E, Intong L, Murrell DF: Scalp scratching – head lice. Medical Observer June 12th, 2009, p 34. Cannon S, Cohn HI, Uitto J, Murrell DF: Unassuming papules: pseudoxanthoma elasticum. Medical Observer July 10th, 2009, p. 38.
Sensen K, Murrell DF: The stretchy skin syndrome. (Ehler’s Danlos) Medical Observer August 8th 2009, p. 36.
Baillie L, Murrell DF: The variations of pityriasis versicolor. Medical Observer, Sept 4th, 2009, p. 30.
Baillie L, Murrell DF: Calciphyllaxis: a rare and severe disorder. Medical Observer Oct 8th, 2009.
Morin C, Intong LRA, Murrell DF: Athlete’s Foot. Medical Observer, Nov 6th, 2009, p. 28.
Pawar P, Murrell DF: Opportunistic Infections. Medical Observer, Nov 27th, 2009, p. 29.
9 6. Presentations at Scientific Meetings/Conferences
International
Prof Dedee F Murrell:
INVITED LECTURES
International Society for Dermatology, Prague, Czech Republic, May 2009 Paediatric Dermatology Symposium: Bullous Genodermatoses International Society for Dermatology, Prague, Czech Republic, May 2009 Paediatric Dermatology Symposium: Bullous Genodermatoses
Society for Pediatric Dermatology, Annual Meeting, Philadelphia, PA, USA, July 9-12, 2009 Sidney Hurwitz Lecturer: What’s New in EB: diagnosis and pathogenesis What’s New in EB: management.
Dept of Dermatology, Zagreb, Croatia, Sept 14th, 2009 Visiting Professor Novel findings in bullous diseases in Australasia
Dept of Dermatology de Prof Carle Paul, Purpan Hospital, University of Toulouse, Toulouse, France, 5th October, 2009 Quoi de neuf dans les épidermolyses bulleuses?
European Academy of Dermatology, Berlin, Germany, Oct 2009 The mother with Epidermolysis Bullosa – what are the problems? In: Symposium on Skin Diseases in Pregnancy
10 CONFERENCE CONTRIBUTIONS
American Academy of Dermatology, San Francisco, March 5-10 Chair, Symposium on Autoimmune Blistering Diseases Speaker, Forum on Genodermatoses Poster Discussion Sessions (incl. How to run a ski camp for EB; Australasian EB Registry)
International Society of Dermatology, Prague, Czech Republic Chair, Maria Duran Symposium Chair, Eurasian Dermatology Platform Speaker: Development of Quality of Life Score for Epidermolysis Bullosa Speaker: Paediatric Dermatology Symposium, Bullous Genodermatoses
Society for Pediatric Dermatology, Philadelphia, PA July 9-12th Sidney Hurwitz Lecturer for 2009 (2 lectures): What’s new in diagnosis and pathogenesis of EB Update on the management of EB
Epidermolysis Bullosa 2009 (invitation only), Vienna Sept 6-8th Moderator: Cell therapy for EB – oral presentation Posters: Quality of life scale for EB; EB Registry ; Cell tx & EB
European Society for Dermatological Research, Budapest, Sept 9-12th Speaker: RCT of allogeneic fibroblast cell therapy for RDEB* Co-Chair, International Consensus for Bullous Pemphigoid Posters: SCC in EB; EBS & ankyloblepharon; EBS-MD Coauthor presentation: Fli expression in EB subtypes (plenary)* *highlighted in summing up as major findings
European Academy of Dermatovenereology, Berlin, Germany, Oct 7-10th Co-Chair, International Consensus for Bullous Pemphigoid Co-Chair, Junior Session for the best research presentations Invited Speaker: Outcomes of pregnancy and delivery in EB Speaker: Systematic Review of Interventions for Pemphigus Speaker: How to take biopsies for EB (WDS symposium) Poster: Quality of Life measure for EB.
Other international presentations by research fellows and students:
Choi SD, Kho YC, Rhodes LM, Chapman MG, Murrell DF: Outcomes of 10 pregnancies in 3 patients with recessive forms of epidermolysis bullosa. American Academy of Dermatology, San Francisco 2009 (Poster).
11 Kho YC, Agero ALC, Rhodes LM, Varigos G, Su J, Orchard D, Murrell DF: The Australasian Epidermolysis Bullosa Registry. American Academy of Dermatology, San Francisco 2009 (Selected for best Poster Discussion).
Chee SN, Rhodes LM, Murrell DF: A comparison of dermatology life quality index (DLQI) scores in a dermatology practice setting. American Academy of Dermatology, San Francisco 2009 (Poster).
Vestergaard ME, Kossard S, Murrell DF: Seborrheic keratoses appearing in sites of previous psoriasis plaques during responsive treatment with efalizumab. American Academy of Dermatology, San Francisco 2009 (Poster).
Frew JW, Lahmar JJ, Nading MA, Kemble-Welch A, Murrell DF: How to organize a ski and adventure camp for young patients with Epidermolysis Bullosa American Academy of Dermatology, San Francisco 2009 (Selected for Poster Discussion ).
Intong LRA, Choi D, Kho YC, Shipman AR, Rhodes LM, Chapman M, Murrell DF: Retrospective Evidence of Outcomes of Pregnancy and Childbirth in Epidermolysis Bullosa in Australia. American Academy of Dermatology, San Francisco 2009 (Poster).
Intong LRA, Green J, Sinclair R, Kossard S, Murrell DF: Unusual frontal variant of loose anagen syndrome. American Academy of Dermatology, San Francisco 2009. Oral Paper, Gross and Microscopic Symposium. .
Kopecki Z, Arkell R, Ludwig R, Zillikens D, Murrell DF and Cowin A.J: Cytoskeletal protein Flightless I affects Cellular Adhesion and Blister Formation in Epidermolysis Bullosa. Plenary session oral presentation, European Society for Dermatological Research, Budapest, Hungary, Sept 2009. J Inv Dermatol 129: S79, 2009.
Halim I, Yan WF, King–Ismael D, Tran K, Melbourne W, Figueira EC, Chow CW, Lloyd L Murrell DF A novel keratin 5 splice site mutation in a Filipino family resulting in epidermolysis bullosa simplex associated with ankyloblepharon. Poster 278, ESDR Budapest 2009; J Inv Dermatol 129: S47, 2009.
Yan WF, Venugopal SS, Frew JW, Tran K, Sturm M, Fogarty J, Marinkovich P. Igawa S, Ishida- Yamamoto A Murrell DF Investigation of cell therapy for generalized severe recessive dystrophic epidermolysis bullosa by intradermal allogeneic fibroblasts randomized against placebo injections. Clinical oral session, ESDR Budapest 2009 #166. J Invest Dermatol: 129: S28, 2009.
Klausseger A, Wadell L, Grasern N, Lloyd L, Tran K, Bauer JW, North K, Murrell DF: Gradual expression of plectin deficiency in a patient with epidermolysis bullosa simplex and adult-onset muscular dystrophy. Poster, ESDR Budapest 2009, J Invest Dermatol 129:S51, 2009.
Cole Cl, Pourreyron C, Foerster J, Purdie K, Salas-Alanis JC, Murrell DF, Bruckner-Tuderman L, McGrath JA, Leigh IM, South AP: SLCO1B3 expression in recessive dystrophic epidermolysis bullosa associated squamous cell carcinoma is reduced by recombinant type VII collagen. Poster, ESDR Budapest 2009, J Invest Dermatol 129: S55, 2009,
12 Boyce AE, McGrath JA, Techanukul T, Tran K, Chow CW, McGregor L, Murrell DF, Warren L: Ectodermal dysplasia-skin fragility syndrome due to a novel internal deletion mutation in the plakophilin 1 gene. Poster, World Congress of Pediatric Dermatology, Bangkok, Thailand, Nov 2009.
D. Sebaratnam, S. Venugopal, D. Murrell. Diffuse melanosis cutis: a systematic review [oral presentation]. Australasian Dermatopathology Society 30th Annual Conference. Heritage, New Zealand. August 22, 2009
National
Prof Dedee F Murrell 3rd Epidermolysis Bullosa National Conference, Queensland, June 12-13, 2009 Keynote speaker – Current research in Epidermolysis Bullosa
University of NSW Medical Society Career obstacles and benefits of dermatology for women 10th Aug 2009
Royal Brisbane Hospital, Dept of Pathology, Oct 2009 Research in Epidermolysis Bullosa from St George Hospital
DebRA South Australia EB Conference, Adelaide, 30th Nov 2009 Cell therapy for recessive dystrophic EB.
Dept Members
Venugopal SS, Intong LRA, Cohn HI, Mather-Hillon J, Murrell DF: An intra-patient, prospective study of topical Gentian Violet for the treatment of chronic ulcers in non-Herlitz Junctional Epidermolysis Bullosa. Australasian College of Dermatologists’ Spring Meeting, Hunter Valley, NSW. Poster. Australas J Dermatol, 50 (Suppl 2) A56, 2009. .
Sebaratnam D, Venugopal S, Murrell DF. The development of an Excel program to compare disease-specific instruments for assessing activity and extent of autoimmune bullous disease [oral presentation]. Australasian College of Dermatology Biennial Spring Conference 2009. Pokolbin, New South Wales, Australia. October 9, 2009
Intong LR, Choi SD, Kho YC, Chapman M, Murrell DF. Retrospective evidence on outcomes and experiences of pregnancy and childbirth in Epidermolysis bullosa in Australia and New Zealand (Poster). (2009).Australasian College of Dermatology 42nd Annual Scientific Meeting, Gold Coast, Australia.
D. Sebaratnam, S. Chee, S. Venugopal, L. Rhodes, B. Welsh & D. Murrell. Advances in the clinical assessment of autoimmune bullous disease: the development of the Autoimmune Bullous Disease Quality of Life questionnaire – the ABQOL [oral presentation]. Australasian Society for Dermatology Research 6th Annual Scientific Meeting, Queensland, Australia. May 20, 2009
13 7. Community Engagement
Australasian Blistering Diseases Foundation – Patient support group meetings organized on St George Campus and fundraising to support research into lifethreatening blistering diseases.
DebRA Australia – annual meeting on Sunshine Coast for patients – Prof Murrell gave talks and Lesley Rhodes, Minhee Kim and Lesley Rhodes volunteered to assist EB patients attending.
Butterfly Day – fundraising for DebRA – organized by Lesley Rhodes in front lobby of St George Hospital.
14 DEPARTMENT OF EMERGENCY MEDICINE
1. Departmental Staff
Head of Department Dr Trevor Chan (Acting Director) : MBChB(Otago), DipPaeds(SCH), FACEM. Conjoint lecturer UNSW
Research Staff Dr Stephen Asha (ED) MBBS, BSc, FACEM, Director of Emergency Medicine Research, Conjoint lecturer UNSW
Senior Consultant Staff Adam Chan MBBCh FACEM Peter Grant MBBCh FACEM Donovan Dwyer MBBCh DCH DipPEC FACEM. Conjoint lecturer UNSW Natasha Ching MBBCh FACEM Megan Cox MBBCh FACEM Alex Tzannes MBBCh FACEM Geoff Mifsud MBBCh FACEM Sarah Coombes MBBCh FACEM Steve Korbel MBBCh FACEM Carissa Oh MBBCh FACEM Simone Moore MBBCh FACEM Sandra Brownlea MBBCh FACEM Jacqui Weeden MBBCh FACEM
Senior Nursing Staff Antoinette Borg (Senior nurse manager) RN Leanne Horvat (Clinical nurse consultant) RN Belinda Kennedy (Nurse educator) RN Kate Jarrett (Clinical nurse educator) RN Allan Ajami (Clinical NUM) RN, BN, Grad cert (ED)
Nurse Practitioners Jacqui Fong RN Tessa Rogers RN Patsy Jiang RN
Junior Medical Staff Angela Foo (Emergency Medicine Fellow) MB BS Dr Janette Keady (Emergency Medicine Advanced Trainee) MB BS Dr Nikki Grant (Emergency Medicine Advanced Trainee) MB BS
15 Natalie Woo (Emergency Medicine Advanced Trainee) MB BS Samantha Wong (Emergency Medicine Advanced Trainee) MB BS Kenny Wan (Emergency Medicine Advanced Trainee) MB BS Timothy Tay (Emergency Medicine Trainee) MB BS Katrina Tsacalos (Emergency Medicine Trainee) MB BS Mary Stevens (Emergency Medicine Advanced Trainee) MB BS William Siu (Emergency Medicine Trainee) MB BS Carla Morgan (Emergency Medicine Advanced Trainee) MB BS Deborah Levy (Emergency Medicine Advanced Trainee) MB BS Emma Ku (Emergency Medicine Advanced Trainee) MB BS Murali Krishnaraj (Emergency Medicine Advanced Trainee) MB BS Khaing (Emergency Medicine Trainee) MB BS Kievan Javan (Emergency Medicine Trainee) MB BS Anna Ings (Emergency Medicine Trainee) MB BS Rafael Gaszynski (Emergency Medicine Trainee) MB BS Sarah Edwards (Emergency Medicine Trainee) MB BS Michael Culshaw (Emergency Medicine Advanced Trainee) MB BS Kathryn Titmuss (Emergency Medicine Advanced Trainee) MB BS Mohammad Hassan (Emergency Medicine Trainee) MB BS
2. Research Grants
Multicultural health service cultural diversity health enhancement grants project. $8500. First Aid Skills Training (“FAST”) Project for CALD groups. Ajami, Asha, Chalitta.
16 3. Research Projects in Progress
No effect of time of day at presentation to the Emergency Department on the outcome of patients who are admitted to the Intensive Care Unit. Asha, Titmuss, Black.
Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a ‘panscan’ protocol Asha, Grant, Smart, Compangnoni, Taylor & Curtis.
Subdural Haemmorrhage in older persons: a comparison of outcomes between those on anticoagulants at the time of injury and those not. Asha, Keady, Curtis & Kohan.
Does the use of patient controlled analgesia in blunt thoracic trauma reduce complications and improve outcome? Asha, Curtis, Kwok, Langcake. A 12 Month evaluation of the impact of Transitional Emergency Nurse Practitioners in one metropolitan Emergency Department. Fry, Fong, Asha, Arendts.
A randomized trial of two types of tissue glue comparing outcomes, complications and pain scores. Dwyer, Ikeda, Arendts.
17 DEPARTMENT OF ENDOCRINOLOGY & METABOLISM
1. Departmental Staff
Head of Department Dr Peter Rohl MB.BS, FRACP
Senior Medical Staff
Staff specialists A/Prof Anthony O’Sullivan MB.BS, MD, MHPEd, FRACP A/Professor of Medicine UNSW A/Prof Terrence Diamond MB. BCh, MRCP, FRACP Conjoint A/Professor of Medicine UNSW
Junior Medical Staff Dr Naswrin Moin Advanced trainee in Endocrinology
Research Staff Dr Terri Golombick MSc, PhD, Dipl Nutr.
Coordinator Osteoporosis Support Group Mrs Antoinette O’Sullivan
2. Research Grants
NHMRC Project Grant 2007-10; $624,250. A randomised controlled trial of progressive resistance training in older diabetics at cardiovascular risk. Fiatarone-Singh M, Blair S, Singh N, O’Sullivan AJ, Simar D, Baune B.
3. Research Projects in Progress
Vitamin D and myeloma: Circumin and myeloma – in vivo and in vitro studies. Principal investigators: A/Prof T Diamond and Dr T Golombick
18 4. Original Peer - Reviewed Publications
Kalmes DF, Comstock BA, Diamond TH et al. A randomised trial of vertebroplasty for osteoporotic spinal fractures. NEJM 2009; 361:569-579
Diamond TH, Golombick T. The role of quantitative ultrasound of the calcaneus for detecting osteoporosis in patients with stress fractures of the feet. Bone 2009; 44; 574-75
Golombick T, Diamond TH, Badmanev V et al. The potential role of circumin in MGUS – its effect on paraprotein and urinary N-telopeptides. Clin Cancer Res 2009; 15: 5917-22
Wong LY, Diamond TH. Severe ophthalmopathy developing after treatment of co-existing malignant struma ovarii and Graves’ disease. Thyroid 2009; 10; 1125-8
Diamond TH, Mason RS. The pleiotrophic effects of vitamin D – understanding its significance for bone and systemic health. Medicine Today 2009; 10: 18-25
Diamond Th, Ebeling P. Treatment options for men with osteoporosis. Medicine Today 2009; 10: 44-56
Fiatarone Singh M, Singh NA, Hansen DA, Diamond TH et al. Methodology and baseline characteristics for the Sarcopenia and Hip Fracture Study. J Gerontology 2009; 64: 568-74
Lloyd B, Williamson DA, Singh ND, Ross H, Diamond T et al. Recurrent and injurious falls in the year following hip fracture: a prospective study of the incidence and risk factors for the Sarcopenia and Hip fracture Study. J Gerontology 2009; 64: 599-609
Leung KC, Xu A, Craig M, Martin A, Lam KSL, O’Sullivan AJ. Adiponectin isoform distribution in women: relationship to female sex steroids and insulin sensitivity. Metabolism 2009; 58: 239-245.
Brillante DG, O’Sullivan AJ, Johnstone MT, Howes LG. Predictors of inotropic and chronotropic effects of NG-monomethyl-L-arginine. European J Clin Invest 2009; 39: 273-279.
19 O’Sullivan AJ. Does oestrogen allow women to store fat more efficiently? A biological advantage for fertility and gestation. Obes Rev 2009; 10: 168-177.
Huang DS, O’Sullivan AJ. Short-term oral oestrogen therapy dissociates the growth hormone/IGF-I axis without altering energy metabolism in premenopausal women. Growth Hormone & IGF Research 2009; 19: 162-167.
Brillante DG, O’Sullivan AJ, Howes LG. Arterial stiffness in insulin resistance: the role of nitric oxide and the angiotensin II receptors. Vasc Health Risk Manag 2009; 5: 73-78.
Hall N, White C, O’Sullivan AJ. The relationship between adiponectin, progesterone and temperature across the menstrual cycle. J Endocrinol Invest 2009; 32: 279-283.
Brillante DG, O’Sullivan AJ, Brillante RE, Howes LG. Effects of cardiovascular angiotensin II type 1 receptor blockade on nitric oxide synthase inhibition in patients with insulin resistance syndrome. Blood Press 2009; 18: 142-148
20 5. Other published material
Presentations at Scientific Meetings/Conferences
National Golombick T, Diamond TH, Badmanev V et al. The potential role of circumin in MGUS – its effect on paraprotein and urinary N-telopeptides. International Bone and Mineral Society
Golombick T, Diamond TH, Badmanev V et al. The potential role of circumin in MGUS – its effect on paraprotein and urinary N-telopeptides. Clin Cancer Res 2009; 15: 5917-22. Annual Scientific meeting of HSANZ (Adelaide)
Diamond TH, Golombick T. Severity of osteoporosis in multiple myeloma and the progmostic role of lumbar spine QCT. Annual Scientific Meeting of HSANZ (Adelaide)
A/Prof A O’Sullivan. Novo Nordisk Endocrine Weekend 2009, Terrigal, NSW. “Amiodarone-induced thyrotoxicosis”.
A/Prof A O’Sullivan. Sydney Children’s Hospital Grand Rounds, “Assessment of professionalism in medical students and fitness to practise”.
A/Prof A O’Sullivan. The Australian Thyroid Foundation, Sutherland Hospital, NSW. “Update on thyroid disease”.
6. Community Engagement
Osteoporosis Support Group – twice weekly exercise classes, second monthly lecture programme, social programme and newsletter publication.
21 DEPARTMENT OF GASTROENTEROLOGY & HEPATOLOGY
1. Departmental Staff
Head of Department Prof Ian Cook MB.BS, MD(Syd), FRACP (Conjoint Professor of Medicine, UNSW)
Senior Medical Staff Dr Philip Craig MB.BS, PhD, FRACP (Visiting Medical Officer) Dr John Freiman MB.ChB, PhD, FRACP (Visiting Medical Officer) Prof Michael Grimm MB.BS, PhD, FRACP (Professor of Medicine, UNSW; Head Clinical School) Dr Amany Zekry MB.BS, PhD, FRACP (Snr Lecturer in Medicine, UNSW)
Clinical Associates Dr Marianne Giurgis MB.BS, FRACP
Junior medical staff Dr Florian Grimpen MD (Goettingen), FRACP (Advanced Trainee in Gastroenterology) Dr Lennart Choo MB.BS(Hons) (Advanced Trainee in Gastroenterology) Dr Vipul Aggarwal MB.BS, MD(Gujarat) (Advanced Trainee in Gastroenterology)
Research Staff Senior research staff: Dr Phil Dinning BSc, PhD (Senior Research Fellow, UNSW) Dr Michal Szczesniak BSc, PhD (Post-Doctoral Research Fellow, UNSW) Dr Rajkumar Cheluvappa MB BS, PhD (Post-doctoral Research Fellow, UNSW) Dr Alissa Walsh MB BS, FRACP (National Institute of Clinical Studies, NHMRC Fellow) Dr Clovis Palmer, PhD (Post-doctoral research fellow)
Gastrointestinal Motility Laboratory Supervisor Mr Sergio Fuentealba BSc
Research assistants Ms Koko Bu MB.BS, M.Med (USYD), Research Assistant (SGH, UNSW) Ms Linda Hunt BSc Mr Lukasz Wiklendt B.Comp.Sc. (Hons) Ms Annie Luo BSc (Hons)
Research students Dr Greta Lee MB.BS, FRACP (PhD student) Ms Danica Martiniz (Honours Student)
22 Nursing research staff Ms Lisa Dowdell Clinical Nurse Specialist, Post Graduate Diploma of Nursing Ms Suzanne Polis RN, BN, MPH (research) (Clinical Nurse Consultant, Honorary Associate Lecturer, Faculty of Nursing, Midwifery and Child Health, UTS) PhD student Ms Christine Janssen - Social worker Ms Amber Raco - Clinical Dietitian
2. Research Grants
National, peer reviewed NH&MRC Project Grant: (ID: 455213). 2007-2009: $478,399 Cook IJ, Dinning PG, Lubowski DZ. Defining the colonic abnormality underlying severe constipation and evaluation of a novel therapy for slow transit constipation
NHMRC project grant: (ID: 455466). 2007-2010: $447,000; Grimm MC, Lloyd AR. The appendix in intestinal immunity and in inflammatory bowel disease
NHMRC project grant: (ID: 568771). 2009-2011: $495,000; Tedla N, Grimm MC, Geczy C. Regulation of monocyte and macrophage functions by leucocyte immunoglobulin-like receptors (LILRs)-A5, B1 and B4: roles in intestinal immune tolerance and inflammation
Other funding Medtronic US, Grant in Aid (Investigator initiated): 2007-2009 : $900,00 Cook IJ, Dinning PG. Randomised, cross-over efficacy trial of sacral nerve stimulation in treatment of slow transit constipation.
Medtronic Australia, Grant in Aid (Investigator initiated): 2007 – 2009 $79,500 Cook IJ, Dinning PG. RCT sacral nerve stimulation in treatment of slow transit constipation.
St George Medical Research Foundation; Establishment Grant: 2009: $40,000 Dinning PG. Automated analysis of colonic manometry: Creating a diagnostic tool for patients with severe constipation.
23 3. Research Projects in Progress
The role of afferent pathways in the mediation of oesophageal reflexes and symptoms (oesophago-pharyngeal regurgitation, chest pain, functional heartburn, globus and dysphagia). Szczensiak MM, Fuentealba S, Omari T, Chen CL, Cook IJ.
The role of secondary peristalsis in non-obstructive dysphagia. Szczensiak MM, Chen CL, Fuentealba S, Cook IJ
Safety and outcomes following treatment of oesophageal disorders causing dysphagia. Kumbahri V, Fuentealba S, Elliott T, Wu PI, Metz A, Cook IJ.
The role of wireless capsule endoscopy in Crohn’s disease patients to assess clinical remissions and predict future relapses. Aggarwal V, Connor S, Scott D, Grimm M, Craig PI.
Multi-centre evaluation of the utility of the Coagrasper in upper and lower gastrointestinal tract bleeding. Tam W, Chen R, Zimmerman M, Craig P, Ormonde D, Shetti M, Singh R
Can a prototype contrast capsule enhance capsule endoscopy image quality? Aggarwal V, Craig PI
Balloon-assisted direct peroral cholangioscopy using an ultraslim gastroscope. Aggarwal V, Craig PI
Biomechanics of the pharyngeal swallow following laryngectomy. Szczesniak MM, MacLean J, Perry A, Cook IJ.
Impact of head and neck radiotherapy on pharyngeal swallowing and biomechanics. Szczesniak MM, MacLean J, Graham P, Cook IJ.
Relationships among bowel symptoms, colonic transit and colonic motor activity. Dinning PG, Talley NJ, Jones M, Fuentealba S, Cook IJ.
Identification of potential manometric biomarkers in slow transit constipation. Dinning PG, Arkwright J, Scott M, Lubowski DZ, Cook IJ.
Evaluation of the influence of sacral nerve stimulation on colonic propagating motor patterns. Dinning PD, Hunt L, Fuentealba S, Lubowski DZ, Arkwright J, Scott M, Cook IJ.
Randomised controlled trial of the efficacy of sacral nerve stimulation in severe slow transit constipation. Dinning PD, Hunt L, Fuentealba S, Lubowski DZ, Cook IJ.
24 Impact of recording technique, catheter design and experimental conditions on human colonic motor patterns. Dinning PD, Hunt L, Fuentealba S, Lubowski DZ, Arkwright J, Scott M, Cook IJ.
The role of descending inhibition in transport of fluid content in the colon. Sinnott MD, Cleary PW, Wang CX, Arkwright JW, Dinning PG.
Three dimensional visualisation of colonic manometry data. Davidson JB, O’Grady G, Pullan AJ, Dinning PG.
Relating gut movement and intraluminal manometry in the isolated rabbit small intestine. Dinning PG, Costa M, Arkwright JW, Wiklendt L, Hennig G, Brookes SJ, Spencer NJ.
The potential impact of laxative use on stool form and frequency in patients with slow transit constipation. Dinning PG, Jones M, Hunt L, Lubowski DZ, Kalantar J, Cook IJ.
A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Arkwright JW, Blenman NG, Underhill ID, Maunder SA, Spencer NJ, Costa M, Brooks SJ, Szczesniak MM, Dinning PG.
Automated analysis of high resolution colonic manometry. Wiklendt L, Dinning PG.
Role of the appendix in intestinal immunity. Grimm MC, Lloyd AR, Eri R
Opportunistic infection in inflammatory bowel disease: altering physician behaviour. Walsh A, Grimm MC
The contribution of leucocyte immunoglobulin-like receptiors to maintenance of intestinal immune homeostasis. Tedla N, Grimm MC, Lee G, Geczy C.
The role of mast cell specific serine proteases in inflammatory bowel disease in mice and humans. Krilis S, Stephens R, Grimm MC
Campylobacter concisus and its role in the aetiology and pathogenesis of early inflammatory bowel disease. Zhang L, Mitchell H, Day AS, Grimm MC
25 Measuring the medical student experience. Grimm MC, Boyle P, McNeil HP. Role of miRNA 135a in regulating hepatic inflammation and steatosis in chronic hepatitis C and non-alcoholic fatty liver disease- Palmer C, Lloyd A and Zekry A
Effect of suppressor of cytokine 3 on the anti-HCV immune responses in obese subjects with chronic hepatitis C virus infection- Martinez D, Palmer C, Simari D , Lloyd A and Zekry A
Altered glucose metabolism within T cells adversely affects CD8 T cell function in chronic hepatitis C virus infection. Baharuddin B, Simar D, Palmer C, Lloyd A and Zekry A
Regulation of T cell recruitment and inflammation in the HIV/HCV co-infected liver. Nguyen N, Zekry A and Lloyd A
Barriers to access of health services inthe migrant population with viral hepatitis. Guriguis M, Zekry A
Factors determining adherence to therapy for chronic hepatitis B virus infection. Polis S, Zekry A and Maher L
4. Original Peer-Reviewed Publications
Arkwright JW, Blenman NG, Underhill ID, Maunder SA, Szczesniak MM, Dinning PG, Cook IJ. In-vivo demonstration of a high resolution optical fiber manometry catheter for diagnosis of gastrointestinal motility disorders. Optics Express 2009;17(6):4500-4508.
Chen CL, Szczesniak MM, Cook IJ. Evidence for esophageal visceral hypersensitivity and aberrant symptom referral in patients with globus. Neurogastroenterol Motil 2009;21:1142-e96.
Dinning PG, Szczesniak MM, Cook IJ. Spatio-temporal analysis reveals aberrant linkage among sequential propagating pressure wave sequences in patients with symptomatically defined obstructed defecation. Neurogastroenterol Motil 2009;21(9):945-e75.
Arkwright JW, Underhill JW, Maunder SA, Blenman NG, Szczesniak MM, Wiklendt L, Cook IJ, Lubowski DZ, Dinning PG. Design of a high-sensor count fiber optic manometry catheter for in vivo colonic diagnostics.Optics Express 2009;17(25):22423-22431.
26 Szczesniak MM, Rommel N, Dinning PG, Fuentealba SE, Cook IJ, Omari T. Intraluminal impedance detects failure of pharyngeal clearance during swallowing: A validation study in adults with dysphagia. Neurogastroenterol Mot. 2009: 21(3):244-52.
Szczesniak M.M., Williams R.B.H., Brake H.M., Maclean J.C., Cole I.E., Cook I.J. Upregulation of the oesophago-UOS relaxation response: a possible pathophysiological mechanism in suspected reflux laryngitis. Neurogastroenterology & Motility 2009; 10.1111/j.1365-2982.2009.01452.
Scott DA, Craig PI. Localisation in the small bowel of lesions found by capsule endoscopy for obscure gastrointestinal bleeding. VHJOE 2009; 8, No 4.
Cheluvappa R, Denning G, Lau G, Grimm MC, Hilmer S, Le Couteur D. Pseudomonas aeruginosa and the hyperlipidemia of sepsis. Pathology 2009;41(7),615–621
Boyle P, Grimm MC, McNeil HP, Scicluna H. The UNSW Medicine Student Experience Questionnaire (MedSEQ): A synopsis of its Development, Features and Utility. UNSWorks at http://handle.unsw.edu.au/1959.4/41332
Milner KL, van der Poorten D, Trenell M, Jenkins AB, Xu A, Smythe G, Dore GJ, Zekry A, Weltman M, Fragomeli V, George J, Chisholm DJ. Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance. Gastroenterology. 2010 Mar;138(3):932-41.e1-3. Epub 2009 Dec 4.
Guirgis M, Zekry A, Yan K, Bu YM, Lee A. J Chronic hepatitis B infection in an Australian antenatal population: seroprevalence and opportunities for better outcomes. Gastroenterol Hepatol. 2009 Jun;24(6):998-1001.
Zekry A Cytokines and liver injury in chronic HCV genotype 4 infection. J Gastroenterol Hepatol. 2009 Mar;24(3):332-5.
Palmer C, Corpuz T, Guirguis M, O’Toole S, Yan K, Bu Y, Jorgenson J, Talbot M, Loi K, Lloyd A, Zekry A. The effect of obesity on intrahepatic cytokine and chemokine expression in chronic hepatitis C infection. Gut. 2010 Mar;59(3):397-404. Epub 2009 Mar 15.
27 5. Other published material (Books, book chapters, reviews,)
1. Cook IJ. Oropharyngeal dysphagia. In: Talley NJ, Tangalos EG, eds. Gastroenterol Clin N Am; Gastroenterology in the Elderly: Saunders, 2009:411-31.
2. Cook IJ, Talley NJ, Benninga MA, Rao SS, Scott SM. Chronic constipation: Overview and challenges. Neurogastroenterol Mot 2009;21(s2):1-8.
3. Dinning PG, Smith TK, Scott SM. Pathophysiology of colonic causes of chronic constipation. Neurogastroenterol Motil. 2009 Dec;21 Suppl 2:20-30.
4. Brookes SJ, Dinning PG, Gladman MA. Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies. Neurogastroenterol Motil. 2009 Dec;21 Suppl 2:9-19.
5. Knowles CH, Dinning PG, Pescatori M, Rintala R, Rosen H. Surgical management of constipation. Neurogastroenterol Motil. 2009 Dec;21 Suppl 2:62-71.
6. Grimm MC. New and emerging therapies in inflammatory bowel disease. J Gastroenterol Hepatol 2009; 24(s3):S69-S74
6. Presentations at Scientific Meetings/Conferences
International
1. Cook IJ. Challenges in constipation. Current Perspectives in Chronic Constipation: A scientific and clinical symposium. Queen Mary University of London. London. Feb 2009.
2. Dinning PG. Colorectal Motor Dysfunction. Current Perspectives in Chronic Constipation: A scientific and clinical symposium. Queen Mary University of London. London. Feb 2009.
3. Cook IJ. Classification, definitions and diagnostic categories of constipation. Current Perspectives in Chronic Constipation: A scientific and clinical symposium. Queen Mary University of London. London. Feb 2009.
4. Dinning PG. Sacral Nerve Stimulation and Pacing. Third Joint International Neurogastroenterology and Motility Conference. Chicago USA. Aug 2009.
5. Dinning PG. Sub-sensory sacral nerve stimulation does not induce colonic propagating pressure waves in patients with slow transit constipation. Neurogastroenterology and Motility Joint International Conference, Chicago, USA, Aug 2009.
6. Dinning PG. High-resolution fibre-optic pressure sensing throughout the entire length of the human colon. XIth Little Brain Big Brain Meeting, Kenosha Wisconsin, USA, Aug 2009.
28 7. Szczesniak MM, Maclean J, Cotton S, Cook IJ, Perry A, Videomanometric evaluation of dysphagia following total laryngectomy, Third Joint International Neurogastroenterology and Motility Conference. Chicago USA. Aug 2009.
8. Role of miRNA in regulating inflammation and lipid accumulation in chronic hepatitis C virus infection. American Association of the Study of Liver disease- Boston 2009.
National:
1. Cook IJ. Pneumatic dilatation is the optimal therapy for achalasia. Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney, Oct 2009.
2. Dinning PG. Sacral Nerve Stimulation for constipation. Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney. Oct 2009.
3. Dinning PG. Sacral nerve stimulation at sub-sensory levels does not induce colonic propagating pressure waves in patients with slow transit constipation . Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney, Australia, Oct 2009.
4. Dinning PG. Pan-colonic manometry demonstrates a potential biomarker of disease in patients with severe slow transit constipation. Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney, Australia, Oct 2009.
5. Dinning PG. Bowel preparation alters the spatiotemporal organisation and the amplitude of colonic propagating sequences. Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney, Australia, Oct 2009.
6. Szczesniak MM, Maclean J, Cotton S, Cook IJ, Perry A. Videomanometric Evaluation of Dysphagia Following Total Laryngectomy. Australian Gastroenterology Week, Sydney, Oct 2009
7. Tam W, Chen R, Zimmerman M, Craig P, Ormonde D, Shetti M, Singh R. Multi-centre evaluation of the utility of the Coagrasper in upper and lower gastrointestinal tract bleeding: Preliminary results. Australian Gastroenterology Week, Sydney, Oct 2009
8. Aggarwal V, Grimm M, Connor S, Scott D, Craig PI. Capsule endoscopy findings in small bowel Crohn’s disease patients in clinical remission: Correlation with CDAI. Australian Gastroenterology Week, Sydney, Oct 2009.
9. Craig PI. Holmium laser lithotripsy of large calculi. Australian & New Zealand Endoscopy Leaders Forum, Port Douglas, Aug 2009
10. Craig PI. Biliary malignancies: What else works? Australian Gastroenterology Week, Sydney, Oct 2009.
11. Craig PI. Hot topics: Aspirin, Plavix and PPI’s. Australian Gastroenterology Week, Sydney, Oct 2009.
29 12. Craig PI. Capsule Endoscopy Workshop convener Melbourne & Brisbane Dec 2009.
13. Luo AS, Grimm MC. A protective role for Th17 cells in inflammatory bowel disease following appendicitis induction? Australian Society for Immunology meeting, Gold Coast Dec 2009
14. Lee GSC , Borges L , Grimm MC, Tedla N. Leukocyte Immunoglobulin-Like Receptors in the Human Gastrointestinal Tract. Australian Society for Immunology meeting, Gold Coast Dec 2009
15. Luo AS, Grimm MC. Th17 cells in the immunopathogenesis of intestinal protection. Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney, Oct 2009
16. Luo AS, Ng WSW, Grimm MC. Localisation and phenotype of protective lymphocytes in the colon of mice following appendicitis. Australian and New Zealand Medical and Surgical Gastrointestinal Week, Sydney, Oct 2009.
17. Zekry A, Drug therapy for non-alcoholic fatty liver disease - Australian Gastroenterology Week 2009
18. Zekry A, Effect of obesity on the immune response in chronic hepatitis C. Colloquium on liver inflammation and Cancer. Centenary Institute, 2009
19. Palmer C, Lloyd A and Zekry A. miRNA in the regulation of hepatic inflammation and lipid accumulation in chronic hepatitis C. Australian Gastroenterology Week 2009\
20. Martinez D, Lloyd A and Zekry A, Interferon stimulated genes in obese subjects with chronic hepatitis C virus infection. Australian Centre for HIV and Hepatitis Virology Research (ACH2) 2009.
7. Community Engagement
Zekry A - Enhancing knowledge on viral hepatitis among General Practitioners. Zekry A in association with the multicultural division at RPAH
Zekry A -NSW Ministerial advisory Committee for viral hepatitis
Zekry A - Chairperson for SESIAHS hepatitis C virus advisory group
30 DEPARTMENT OF INFECTIOUS DISEASES, IMMUNOLOGY & SEXUAL HEALTH
1. Departmental Staff
Head of Department Prof. Steven A. Krilis, MB BS PhD FRACP (Conjoint Professor of Medicine UNSW)
Senior Medical Staff Dr. Pamela Konecny, (Director of Sexual Health) MB BS MD DTM&H(Lon) FRACP (Conjoint Snr Lecturer in Medicine UNSW) Dr. Chris Weatherall, MB BS FRACP (Conjoint Snr Lecturer in Medicine UNSW) Dr. Josephine Lusk, BSc MBChB FRNZCGP DRCOG FAChSHM MPH Dip MGT Dr. Judith Gardiner, MB BS DipPH, DipM[Sydney] FAChSHM
Junior Medical Staff Dr. Rory Hannah, MBBS Advanced Trainee Infectious Disease Dr. Robert Stevens, MBBS Advanced trainee Infectious Disease - 6 months Dr Eunice Liu, MBBS BPT, Infectious Disease Registrar – 6 months
Research Staff Dr. Jian Chen Qi M Med (Tianjin Medical University, China), PhD Garvan Institute, Senior Scientist./Laboratory Manager Dr. Bill Giannakopoulos, MBBS, PhD, FRACP, Postdoctoral Fellow Dr. Gao Lu, B Clin Med, Tianjin Medical University, China, PhD Visiting Research Fellow Dr. Freda Passam, DipMed, PhD, Athens University, Visiting Fellow Dr. John Ioannou, CCT (Rheumatology), MRCP (UK), BMedSci, U C, London, Visiting Fellow Dr. Jingyun Zhang, PhD Tianjin Medical University, China, Visiting Research Fellow
Research Assistants Dr. Kumiko Tanaka MSc, PhD, Miao Qi B Med in Med Lab Sc, Tianjin Medical University, China, MSc.
Clinical Trial Co-ordinator Robyn Dever CNS
Research Student Peyman Mirarabshahi, PhD Student Dr Josephine Lusk, PhD student (part-time)
31 2. Research Grants
National, peer reviewed:
NHMRC; 2007 -2009: $558,000 The role of RasGRP4, a mast cell specific protein in mast cell growth, differentiation and activation. Steven Krilis
NH&MRC; 2008 – 2010: $510,000 Pathophysiological Mechanisms in the Antiphospholipid Syndrome. Steven Krilis
Other funding*: Steven Krilis University of New South Wales Goldstar Award; 2009: $40,000 Pathophysiological Mechanisms in the Antiphospholipid Syndrome: Activation of Glycoprotein Ib Alpha
Bill Giannakopoulos Inaugural St George Medical Research Foundation New Investigator Grant; 2009: $20,000
3. Research Projects in Progress
Steven Krilis:
Pathophysiological Mechanisms in the Antiphospholipid Syndrome.
The role of oxidative post-translational modifications of B2GPI in thrombosis and autoimmune disease.
Mass spectrometry of oxidatively post-translationally modified forms of ß2GPI, Professor P. Hogg and Dr. J. Wong, UNSW Cancer Research Centre, University of New South Wales, Sydney.
The role of mMCP-6 in inflammatory bowel disease. Professor Michael Grimm, Department of Gastroenterology St. George Hospital, Professor R L Stevens, Department of Immunology, Rheumatology Harvard Medical School Boston, Mass.
Studies on FXI/FXIa binding to ß2GPI using FXI mutants. Professor D. Gailani, Vanderbilt University, Nashville, Tennessee, USA
Molecular studies on RasGRP4 a specific mast cell GEF. Professor R L Stevens, Department of Immunology, Rheumatology Harvard Medical School Boston, Mass. Crystallization studies of ß2GPI. Investigator: Prof Michael W. Parker, Deputy Director and ARC Federation Fellow, Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Facility, Centre
32 for Structural Neurobiology, St. Vincent’s Institute of Medical Research, Melbourne, VIC.
Collaborating on the study analysing the role of beta 2-glycoprotein I in autoimmunity. Professor K Matthaei: Professor and Head Of The Gene Targetting Group at The John Curtin School of Medical Research.
Collaborating on the study analysing the role of beta 2-glycoprotein I in autoimmunity. Dr D Spielman: Senior veterinary scientist at the Sydney University School of Veterinary Medicine.
Collaborating on analysing the role of B2GPI on the immune response in autoimmune BXSB mice. Dr Robert Brink, Director of the Immunology Research Programme at the Garvan Institute.
Collaborating on a project the lipid metabolism aspect on the study analysing the role of beta 2-glycoprotein I in autoimmunity. Prof Kerri-Ann Rye and Dr Ben Wu from the Heart Research Institute Camperdown
Collaborating on a prospective international multicentre study examining the predictive and diagnostic role of novel ELISAs detecting oxidative post-translational modifications of B2GPI. Senior epidemiologist, Professor Tatsu Atsumi, Department of Medicine University of Sapporo, Hokkaido, Japan. A/Professor D. Erkan, Division of Rheumatology, Hospital for Special Surgery, New York, USA. Professor Takao Koike Head, Department of Medicine, University of Sapporo, Hokkaido, Japan. Professor Michael Lockshin, Head of Medicine at the Hospital for Special Children, New York USA and Director of Rheumatic Diseases and Lupus Research. Professor Harry Moutsopoulos, Director of Department of Medicine, University of Athens, Greece. Professor Michelle Petri, Professor of Medicine, Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, USA. Associate Professor P. Vlachoyiannopoulos, Department of Medicine, University of Athens, Greece. Associate Professor Stephane Heritier at the George Institute for International Health, University of Sydney.
Clinical Trials Robyn Dever CNS Altair study – A Randomised Open Label Study Comparing the Safety and Efficacy of Three Different Combination Antiretroviral Regimens as Initial Therapy for HIV Infection
ICE International Collaboration on Endocarditis (ICE Study)
EVG A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of Ritonavir-Boosted Elvitegravir (EVG/r) Versus Raltegravir (RAL) Each Administered With a Background Regimen in HIV1 Infected, Antiretroviral Treatment-Experienced Adults - Protocol GS- US-183-0145, dated 29 April 2008 (HREC Ref No: 08/SVH/124) Flu An International Observational Study To Characterize Adults Who Are Hospitalized With Complications Of Influenza A – Pandemic H1N1 (H1N1v); INSIGHT H1N1v Hospitalization Study (FLU003) (HREC Ref No: 09/SVH/138)
33 Altair A randomised open-label study comparing the safety and efficacy of three different combination antiretroviral regimens as initial therapy for HIV infection (ALTAIR) (07/14 Dr. P. Konecny)
Cervicitis Infectious organisms associated with Cervicitis in a metropolitan Sydney Sexual Health Clinic population. (Cervicitis study) 06/09 Dr. J. Lusk
4. Original Peer-Reviewed Publications
Reed J., Giannakopoulos B., Jackson M., Krilis S., Gordon T. Ro60 functions as a receptor for Beta 2-glycoprotein I on apoptotic cells. Arthritis Rheum. 2009;60(3):860-9.
Passam FH, Alexandrakis MG, Kafousi M, Fotinou M, Darivianaki K, Tsirakis G, Roussou PA, Stathopoulos EN, Siafakas NM. Histological expression of angiogenic factors: VEGF, PDGFR alpha, and HIF-1alpha in Hodgkin lymphoma. Pathol Res Pract. 2009;205(1):11-20.
Ioannou Y, Z. Romay-Penabad, C. Pericleous, I. Giles, E. Papalardo, G. Vargas, T. Shilagard, D. S. Latchman, D. A. Isenberg, A. Rahman And S. Pierangeli. In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of ß2-glycoprotein I: proof of concept. Journal of Thrombosis and Haemostasis. 2009;5: 833–842
Figtree M, Miyakis S, Stenos J, Graves S, Botham S, Ferson M, Krilis S. Q Fever Cholecystitis in an Unvaccinated Butcher Diagnosed by Gallbladder Polymerase Chain Reaction. Vector-Borne and Zoonotic Diseases. Online Ahead of Print: September 2, 2009.
Ferson MJ, Konecny P. Recent increases in mumps incidence in Australia: the “forgotten” age group in the 1998 Australian Measles Control Campaign. Med J Aust. 2009 Mar 2;190(5):283-4.
Lusk MJ, Uddin R, Ferson M, Rawlinson W, Konecny P. Primary health care providers surveyed commonly misinterpret ‘first void urine’ for chlamydia screening. Sex Health. 2009 Mar;6(1):91-3. Carey D, Baker D, Petoumenos K, Chuah J, Rogers GD, Watson J, Cooper DA, Emery S, Carr A; FLASH Investigators (Konecny P.). Poly-l-lactic acid for HIV-1 facial lipoatrophy: 48-week follow-up. HIV Med. 2009 Mar;10(3):163-72.
34 McIver CJ, Rismanto N, Smith C, Naing ZW, Rayner B, Lusk MJ, Konecny P, White PA, Rawlinson WD. Multiplex PCR testing detection of higher-than-expected rates of cervical Mycoplasma, ureaplasma, and Trichomonas and viral agent infections in sexually active Australian women. J Clin Microbiol. 2009 May;47(5):1358-63.
Rodger AJ, Fox Z, Lundgren JD, Kuller LH, Boesecke C, Gey D, Skoutelis A, Goetz MB, Phillips AN , INSIGHT Strategies for Management of Antiretroviral Therapy (SMART) Study Group (Dr. P. Konecny). Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. J Infect Dis. 2009 Sep 15;200(6):973-83.
Lusk MJ, Naing Z, Rayner B, Rismanto N, McIver CJ, Cumming RG, McGeechan K, Rawlinson WD, Konecny P. Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sex Transm Infect. Epub 2009 Nov 1
5. Other published material
Giannakopoulos B, Passam F, Ioannou Y, Krilis SA. How we diagnose the antiphospholipid syndrome. Blood. 2009 Jan 29;113(5):985-94.
Giannakopoulos B, Krilis SA. How I treat the antiphospholipid syndrome. Blood. 2009 Sep 3;114(10):2020-30.
6. Presentations at Scientific Meetings/Conferences
International
Steven Krilis. Chairman. Etiology of Sjögren’s Syndrome. 10th International Symposium on Sjögren’s Syndrome. Brest, France. 2009.
Steven Krilis. Chair, Clinic & Biology. 10th International Symposium on Sjögren’s Syndrome. Brest, France. 2009.
Steven Krilis. International Scientific Committee. 10th International Symposium on Sjögren’s Syndrome. Brest, France. 2009
Steven Krilis. International Scientific Advisory Board and reviewer XXI Congress of the International Society on Thrombosis and Haemostasis. Boston, USA. 2009.
35 Steven Krilis. Member, Organizing Committee, XIII Congress on Antiphospholipid Antibodies. Galveston, Texas, USA. 2009.
National
Steven Krilis. RasGRP4, a mast cell regulatory protein: role in human mast cell inflammatory disorder. 20th Annual Scientific Meeting Adelaide, South Australia
Chairman, Mast Cell Disorder Symposium. The antiphospholipid syndrome: laboratory diagnosis and clinical manifestations. Australian Society of Clinical Immunology, 20th Annual Scientific Meeting Adelaide, South Australia.
Steven Krilis. HIV and AIDS Lecture for General Practitioners, Sydney.
Pam Konecny. Australasian Society of Infectious Diseases Annual Scientific Meeting, Scientific Committee Member, NSW Mar 2009. Australasian Society of Infectious Diseases Annual Scientific Meeting, Mar, 2009, Invited speaker: STIS for the ID Physician.
SESIAHS Antimicrobial Stewardship Forum Garrawarra, April 2009, Invited Speaker: Antimicrobial Stewardship Program at SGH
Pam Konecny. HIV/AIDS Lecture and Sexual Health Updates for General Practitioners, St George- Sutherland Divisions
Chris Weatherall. Australasian Society of Infectious Diseases Annual Scientific Meeting, Scientific Committee Member, NSW Mar 2009.
Chris Weatherall HIV and AIDS Lecture for General Practitioners, Sydney.
Qi Miao. (Yiannis Ioannou, Jing-Yun Zhang, Freda H Passam, Soheila Rahgozar, Jian Cheng Qi, Bill Giannakopoulos, Pei Yu, Demin M Yu, Philip J Hogg and Steven A Krilis). Naturally occurring free thiols within ß2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells and regulation of oxidative stress induced cell injury. The St George & Sutherland Medical Research Conference, Sydney.
Bill Giannakopoulos. (Spielman D, St de Groth BF, Miao Q, Qi JC, Mathia K, Krilis SA.) The antiphospholipid autoantigen beta 2-glycoprotein I modulates the autoimmune response lupus and non-lupus prone mice. The St George Hospital Medical Symposium, Sydney.
Polis SJ , Bain P, Cain M , Dever R, Stevens R , Krilis, Konecny P, Improving Antiretroviral Adherence In Intellectually Challenged People, ASHM, Brisbane.
Coady John, ‘Camp Goodtime: Group Social Work in an informal setting: A review of an Australian wide service to men in families living with HIV/AIDS’, ASHM, Brisbane. Lusk MJ, Naing Z, Rismanto N, Rayner B, McGeechan K, McIver CJ, Rawlinson WD, Konecny
36 P. Trichomonas vaginalis: Under-diagnosis in Urban Australia could facilitate re-emergence, Australasian Sexual Health Annual Scientific Meeting, Brisbane
Lusk MJ, Naing Z, Rismanto N, Rayner B, McGeechan K, McIver CJ, Rawlinson WD, Konecny P. Mycoplasma genitalium is associated with cervicitis in a Sydney sexual health population. Australasian Sexual Health Annual Scientific Meeting, Brisbane
7. Community Engagement
Interagency Meetings engaging with priority population Community leaders in the St George/Sutherland Area – Multicultural, Youth
Liaison and teaching to St George and Sutherland GP Divisions
37 DEPARTMENT OF INTENSIVE CARE MEDICINE
1. Departmental Staff
Head of Department A/Prof T. Jacques MBBS, FANZCA, FCICM, MHL, Conjoint A/Prof UNSW
Senior Medical Staff: Professor John Myburgh MBBChir, DA (SA), FFARACS, FANZCA, FCICM, PhD, President (College of Intensive Care Medicine), Professor of Critical Care Medicine UNSW, Director (Critical Care and Trauma Division, the George Institute For International Health)
A/Prof G. Skowronski MBBChir, MRCP(UK), FRACP, FCICM
Dr Manoj Saxena MBBChir, BSc, MRCP(UK), FRACP, FCICM, Conjoint Lecturer UNSW, Honorary Fellow (The George Institute for International Health)
Dr Doris Lam MBChB, FANZCA, FCICM, MHL, Conjoint Lecturer UNSW Dr Rahul Pandit MBBS, MD, FCICM, Conjoint Lecturer UNSW Dr Kush Deshpande MBChB, MD, FCICM, Conjoint Lecturer UNSW
Junior Medical Staff Dr Andrew Cheng MBChB(NZ) FJFICM(ANZCA RACP) (Advanced trainee in Intensive Care Medicine) Dr Nhi Nguyen B.Med.Sci, Grad Dip Sci, MBBS, FCICM (Advanced trainee in Intensive Care Medicine) Dr Atul Gaur MBBS, MD,(Advanced trainee in Intensive Care Medicine) Dr Asako Ito MBBS (Advanced trainee in Intensive Care Medicine) Dr Nitin Chavan MBBS, MD. (Advanced trainee in Intensive Care Medicine) Dr Ajay MBBS, MD, (Basic training in Intensive Care Medicine) Dr Carmen Yip MBBS (Basic Training in Intensive Care Medicine)
Nursing Research Staff Deborah Inskip RN, Cert Nurs Intensive care ,Clinical Nurse Specialist (Quality, Education, Research and Information Nurse) Rebecca Sidoli RN, Cert Nurs Intensive care ,Clinical Nurse Specialist (Quality, Education, Research and Information Nurse)
Research Staff Research students: Penelope Aligiannis (Medical student)
38 2. Research Grants
NHMRC Project Grant: 352550 (The RENAL Study); 2005-2009: $1.8M Finfer SR, Cass N Scheinkestel C Norton R, Myburgh JA, Cole L. Randomised Evaluation of Normal vs. Augmented Level Replacement Therapy in the intensive care unit.
NHMRC Enabling grant: 316001. (ANZIC-RC); 2004-2009: $2.5M Bellomo R, Myburgh JA, Finfer SR, Cooper DJ. National Centre for Intensive Care research.
NHMRC Project Grant: 436873 (The StatInS Study):2007-2009: $603 825 Kruger P, Venkatesh B, Bellomo R, Kostner K, Cooper DJ, Roberts M, Myburgh JA. A phase II randomised controlled trial of atorvastatin therapy in intensive care patients with severe sepsis.
NHMRC Project Grant: 491075 (The ARISE Study); 2008-2011: $1.7M Bellomo, R Cameron, P Cooper DJ, Peake SL, Webb S, Delaney A, Holdgate A, Myburgh JA. The Australian Resuscitation in Sepsis Evaluation
NHMRC Project Grant: 545901; 2009-2013:$1.95M Cooper DJ, Bernard S, Nichol A, Presneill J, Cameron P, Myburgh JA. A randomised controlled trial of prophylactic hypothermia in severe traumatic brain injury (POLAR trial)
Canadian Institute for Health Research: Project Grant: 146343; 2006-2009: C$4.88M Cook DJ, Myburgh JA. T The prophylaxis for thromboembolism in critical care trial (The PROTECT trial).
Canadian Institute for Health Research. Project Grant; 2006-2009: C$3.0M Dhingra V, Myburgh JA. The survival using glucose algorithm regulation trial (The SUGAR study).
Other funding Victorian Neurotrauma Institute: Project Grant. 2008-2009: $98 797 Finfer SR, Myburgh JA, Cooper DJ, Higgins A Normoglycaemia in Intensive Care Traumatic Brain Injury Study (The NICE-TBI Study).
Intensive Care Foundation Project Grant. 2009-2010: $80 000 Seppelt I, Myburgh J.A. , Cooper D.J., Finfer S.R., Elliot R. The ANZICS Clinical Trials Group Point Prevalence Program.
Australian and New Zealand College of Anaesthetists Project Grant: 09/008. 2009: $30 000 Saxena M.K, Myburgh J.A., Gowardman J. A phase IIB study of intravenous paracetamol in reducing body temperature after traumatic brain injury. (The PARITY study).
39 St George Medical Research Foundation: Establishment Grant. 2009: $20 000 Saxena M.K., Myburgh J.A., Seppelt I. A prospective cohort study of temperature management after traumatic brain injury in Australia and New Zealand.
3. Research Projects in Progress
1. The ANZIC Influenza Investigators. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. Webb, SAR, Petilla V, Seppelt I, Myburgh JA, Lam D, Inskip D, Sidoli R.
2. Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome Davies AR, Myburgh JA, Lam D, Inskip D, Sidoli R.
3. PARITY: A phase IIB study of intravenous paracetamol in reducing body temperature after traumatic brain injury Saxena M, Myburgh JA, Gowardman J, Taylor C, Glass P, Inskip D
4. A point prevalence study of temperature management after acute brain injury Saxena M, Myburgh JA, Seppelt I, Taylor C, Glass P
5. A retrospective cohort study of temperature management after traumatic brain injury Saxena M, Myburgh JA, Taylor C, Glass P, Seppelt I, Bradford C, Rashid A, O’leary M, Skirfvars M, Bellapart J
6. The CLARITY study: a cross-sectional observational study of temperature management after TBI in low-, middle- and high-income countries. Saxena M, Myburgh JA, Seppelt I, Taylor C, Glass P
7. Influenza Pandemic Protocol for ICU Triage Study Cheung W, Saxena M, Myburgh JA, Gandhi K, Parr M, Thanakrishnan G, Seppelt I
8. The Impact of the Intensive Care Discharge Process on Patients Outcomes: The DARE (Discharge and Readmission Evaluation) Study. Santamaria J, Gattas D, Rajbhandari D, Jacques T.
9. The iCURE study: Intensive Care Unit Readmission Evaluation Jacques TJ, Eather W.
10. The EARLY Parental Nutrition Trial Doig G, Jacques TJ, O’Leary M
40 11. The CHEST study: The crystalloid and hydroxyethyl starch trial Myburgh JA, Saxena M, Inskip D
12. A pilot study evaluating the peri-operative nutritional response in cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis Aligiannis P, Saxena M, Morris D, Liauw
4. Original Peer-Reviewed Publications
The NICE-SUGAR Study Investigators. (Myburgh J.A.: Member: Writing Committee). Intensive blood glucose control in critically ill patients. New England Journal of Medicine. 2009; 360: 1283-1297. [Editorial comment: Inzucchi S.E., Siegel M.D Glucose control in the ICU: how tight is too tight? New England Journal of Medicine 2009; 360: 1346-1348].
The RENAL Study Investigators. (Myburgh J.A.: Member: Writing Committee). Intensity of continuous renal replacement therapy in critically ill patients. New England Journal of Medicine 2009; 361: 1627-1638. [Editorial comment: Palevsky P.(2009). Renal support in acute kidney injury – how much is enough? New England Journal of Medicine 361: 1699-1701].
The RENAL Study Investigators. (Myburgh J.A.: Member: Writing Committee). Screening and study enrolment in the randomized evaluation of normal vs. augmented level renal replacement therapy trial. Blood Purification 2009; 27:199-205.
Myburgh J.A., Finfer S.R. Albumin is a blood product too – is it safe for all patients? Critical Care and Resuscitation. 2009; 11: 67-70.
Peake SL, Bailey M, Bellomo R, Cameron PA, Cross A, Delaney A, Finfer S, Higgins A, Jones DA, Myburgh J.A., Syres G, Webb S, Williams P and the ARISE Investigators, for the Australian and New Zealand Intensive Care Society Clinical Trials Group. Australasian Resuscitation in Sepsis Evaluation (ARISE): a multi-centred, prospective inception cohort. Resuscitation. 2009; 80: 811-818.
Myburgh J.A., Chittock D.R. Differences in outcomes between the NICE-SUGAR and Leuven trials: biological mechanisms of intensive glucose control in critically ill patients. Critical Care and Resuscitation. 2009; 11:178-179. (Editorial).
41 Bellomo R., Morimatsu H., Presnell J., French C., Cole L., Story D., Uchino S., Naka T., Finfer S., Cooper DJ Myburgh J.A., SAFE Study Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group. Effects of saline or albumin on standard coagulation tests. Critical Care and Resuscitation 2009; 11:250-256.
Finfer S.R., Heretier S on behalf of the NICE Study Management Committee and SUGAR Study Executive Committee. (2009). (Myburgh J.A.: Member NICE Study Management Committee). The NICE-SUGAR (Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan. Critical Care and Resuscitation. 11: 46-57. [Editorial comment: Finfer S, Bellomo R. (2009). Why publish statistical analysis plans? Critical Care and Resuscitation. 11: 5-7].
Finfer S.R., Cass A., Gallagher M., Lee J., Su S., Bellomo R on behalf of the RENAL Study Investigators. (Myburgh J.A.: Member Management Committee and Principal Investigator St George Hospital). The RENAL (Randomised Evaluation of Normal vs Augmented Level of renal replacement therapy): statistical analysis plan. Critical Care and Resuscitation.2009; 11: 58-66. [Editorial comment: Finfer S, Bellomo R. Why publish statistical analysis plans? Critical Care and Resuscitation. 2009; 11: 5-7].
Nichol A.D., Cooper D.J, the POLAR and EPO Study Investigators on behalf of the ANZICS Clinical Trials Group. (Myburgh J.A.: Member POLAR study Management Committee). Can we improve neurological outcomes in traumatic brain injury? Something old (prophylactic hypothermia) and something new (erythropoietin). Injury. 2009; 40: 471-478.
The ANZIC Influenza Investigators. (Myburgh J.A.: Principal Investigator: St George Hospital). Influenza A (H1N1) 2009: Critical Care services and 2009 H1N1 influenza A in Australian and New Zealand. New England Journal of Medicine 361: 1925-1934. The Australia and New Zealand Extracorporeal Membrane Oxygenation Influenza Investigators. (Myburgh J.A.: Principal Investigator: St George Hospital). Extracorporeal Membrane Oxygenation for 2009 Influenza A (H1N1) 2009 Acute Respiratory Distress Syndrome. JAMA 2009; 302: 1888- 1895.
42 5. Other published material
Myburgh J.A. Severe Head Injury. In: Oh’s Intensive Care Manual 6th edition. ( Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. 2009 pp. 776-792.
Upton R.N., Myburgh J.A., Morris R. Pharmacokinetics, pharmacodynamics and drug monitoring in critical illness. In: Oh’s Intensive Care Manual 6th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. 2009, pp. 897-912.
Myburgh J.A. Inotropes and vasopressors. In: Oh’s Intensive Care Manual 6th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. 2009, pp. 931-944.
Myburgh J.A. Vasodilators and antihypertensives. In: Oh’s Intensive Care Manual 6th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. 2009, pp. 945-956.
Jacques T. Fisher M, Hillman K, Fraser K (Editors) - DETECT Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0- 9806896-0-0
Jacques T. Fisher M, Hillman K, Fraser K (Editors)- DETECT Instructor’s Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0- 9806896-1-7
Jacques T. (chapter). “When to worry” DETECT Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0-9806896-0-0
Jacques T. (chapter) “When to worry” DETECT Instructor’s Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0- 9806896-1-7
Lam. D (chapter) “The confused patient” DETECT Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0-9806896-0-0
Lam D. (chapter) “ The confused Patient” DETECT Instructor’s Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0- 9806896-1-7
Pandit R (chapter) “ I can’t breathe” DETECT Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0-9806896-0-0
Pandit R (chapter) “I can’t breathe” DETECT Instructor’s Manual: Detecting Deterioration, Evaluation, Treatment, Escalation and Communicating in Teams 1st Edition 2009, ISBN 978-0- 9806896-1-7
43 6. Presentations at Scientific Meetings/Conferences
International Plenary
1. Myburgh J.A. August 2009. (Sun City, South Africa). Large-scale studies on intensive insulin therapy in critically ill patients. Combined Congress of the Critical Care Society of South Africa and the South African Thoracic Society.
2. Myburgh J.A. September 2009. (Weimar, Germany). Albumin in sepsis – an in-depth analysis of the SAFE Study. 4th International Congress of the German Sepsis Society.
3. Myburgh J.A. September 2009. (Weimar, Germany). Why we need the CHEST trial on the safety and efficacy of 6% hydroxyethyl starch 130/0.4. 4th International Congress of the German Sepsis Society.
4. Myburgh J.A. October 2009. (Hong Kong). Optimising glycaemic control in critically ill patients. Annual Scientific Meeting in Anaesthesiology, Hong Kong College of Anaesthesiology and Society of Anaesthesia of Hong Kong.
International invited
1. Myburgh J.A. August 2009. (Sun City, South Africa). Vasoactive agents in critically ill patients. Combined Congress of the Critical Care Society of South Africa and the South African Thoracic Society.
2. Myburgh J.A. August 2009. (Sun City, South Africa). Priorities in management of traumatic brain injury. Combined Congress of the Critical Care Society of South Africa and the South African Thoracic Society. 3. Myburgh J.A. October 2009. (Hong Kong). Evidence for the use of vasopressors in critically ill patients. Annual Scientific Meeting in Anaesthesiology, Hong Kong College of Anaesthesiology and Society of Anaesthesia of Hong Kong.
4. Myburgh J.A. October 2009. (Hong Kong). Determining the optimal dose of renal replacement therapy in critically ill patients. Annual Scientific Meeting in Anaesthesiology, Hong Kong College of Anaesthesiology and Society of Anaesthesia of Hong Kong.
44 National plenary
1. Myburgh J.A. June 2009. (Brisbane). Lessons from NICE-SUGAR: implications for clinicians. Joint Faculty of Intensive Care Annual Scientific Meeting.
2. Myburgh J.A. June 2009. (Brisbane). Colloids: more than intravascular volume expanders? Joint Faculty of Intensive Care Annual Scientific Meeting.
National Invited
1. Myburgh J.A. March 2009. (Noosa). The Crystalloid versus Hydroxyethyl starch Trial (CHEST). Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Meeting.
2. Myburgh J.A. September 2009. (Sydney). Development of a clinical algorithm for intracranial hypertension: the Brain Trauma Foundation consensus process. Australian and New Zealand Intensive Care Society New South Wales Regional Meeting.
3. Saxena M. March 2009. Avoiding pyrexia after traumatic brain injury – a point prevalence program and prospective cohort study. Australia and New Zealand Intensive Care Society Clinical Trials Group Meeting
4. Saxena M. June 2009. An international cross-sectional study of temperature management after TBI in low-, middle- and high-income countries. Australia and New Zealand Intensive Care Society – Clinical Trials Group – Research Development Day.
5. Saxena M. June 2009: How a novice researcher is dependent on small grants to get runs on the board – the case of keeping cool after a bang on the head. The Intensive Care Foundation annual meeting.
6. Saxena M. July 2009: Simple ways to keep cool after brain injury Prince of Wales Hospital, Sydney: Intensive Care Symposium. 7. Saxena M. August 2009: Therapeutic thermal regulation after traumatic brain injury – could less be more? Wagga Wagga Rural Clinical School, University of New South Wales: Regional Update Series
8. Saxena M. October 2009. Avoiding pyrexia after traumatic brain injury – a point prevalence program and prospective cohort study. Australia and New Zealand Intensive Care Society Clinical Trials Group Meeting
45 DEPARTMENT OF NUCLEAR MEDICINE
1. Departmental Staff
Head of Department Dr Patrick Butler MA MD MBA FRACP Conjoint Assoc Professor, UNSW
Senior Medical Staff Dr Scott Beuzeville B(Med) FRACP Dr Richard Quinn MB BS DDU FRACP Dr Ramy Nour MB MS FRACP
Junior Medical Staff Dr Sandeep Sharma MB BS FRACP
Research Staff Senior research staff: Dr Richard Smart BSc MSc PhD MACPSEM FARPS Conjoint Assoc Professor, UNSW Dr Erin Mckay BSc, MSc, PhD Mr Peter McConachie B AppSci MCom Ms Effie Browne BAppSci MScMed
Research Assistants Ms Gabriel Botros BSc
2. Research Projects in Progress
Whole body Imaging after Tc99m SESTAMIBI administration in patients with suspected hyperparathyroidism. A/Prof Patrick Butler
3. Original Peer - Reviewed Publications
Botros G, Smart R, Towson J Diagnostic reference activities for nuclear medicine procedures in Australia and New Zealand derived from the 2008 survey. ANZ Nuclear Medicine, 2009, 40: 2-11
Macfarlane D, Socrates A, Eisenberg P, Larcos G, Roach P, Gerometta M, Smawrt R, Tsui W, Scott A Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab’ fragment (99mTc-DI-DD3B6/22-80B3): results of a phase 1 trial. European Journal of Nuclear Medicine & Molecular Imaging, 2009, 36:250-259
46 DEPARTMENT OF NEUROLOGY
1. Departmental Staff
Mark Hersch BSc, MBBCh, PhD, FRACP, Conjoint Associate Professor UNSW Louise Allport BSc (Med), MBBS, PhD, FRACP Jerome Ip MBBS, FRACP, Conjoint lecturer, UNSW Jane Prosser MBBS, FRACP Walid Matar BMedSci (Hons), MBBS Donald Pryor MBBS, MD, FRACP
2. Research Projects in Progress
Cause of severe urinary incontinence in women with A/Prof. K Moore, Dr E Karantanis and Dr S Sharma
3. Original Peer - Reviewed Publications
Granot R, Lawrence R, Barnett M, Masters L, Rodriguez M, Theocharous C, Pamphlett R, Hersch M What lies beneath the tent? JC-virus cerebellar granule cell neuronopathy complicating sarcoidosis. J Clin Neurosci. 2009; 16: 1091-2
4. Other published material
Pryor, Donald S. “Neurological Emergencies” in “Emergency Medicine, The Principles of Practice” 5th Ed Gordian W O Fulde ed. Elsevier Australia, 2009
5. Presentations at Scientific Meetings/Conferences
International E Karantanis Reseach project mentioned in section 4 - presented at International Continence Society Meeting, San Fransisco Sept 2009 by Dr S Sarma (and also at Austrian Continence Foundation Annual Meeting, Adelaide, 2009.
National Lahoria R, Allport L, Glenn D, Masters L, Shnier, R, Davies, M, Hersch M. Spontaneous Low Pressure Headache - A case report. Annual meeting of ANZAN, Auckland 2009.
47 DEPARTMENT OF RENAL MEDICINE
1. Departmental Staff
Head of Department Professor Mark Brown MBBS, MD, FRACP (Professor of Medicine, UNSW)
Senior Medical Staff Associate Professor John Kelly MBBS, MD, FRACP (Associate Professor of Medicine, UNSW) Associate Professor George Mangos MBBS, MD, FRACP (Associate Professor of Medicine, UNSW) Dr William Chan MBBS, PhD, FRACP Dr Sharon Ong BSc (Med), MBBS, FRACP (Conjoint Lecturer, UNSW) Dr Ivor Katz MD, MBBCh, FCP(SA), BSc Honours, PhD Dr Parthasarathy Shanmugasundaram MBBS, DM, FRACP (Conjoint Lecturer, UNSW) Dr Cathie Lane B.Pharm. B.Med FRACP,Grad Cert ULT, PhD (Conjoint Lecturer, UNSW)
Research Staff Senior research staff Saiyini Pirabhahar BNurs, MHlthSci, Grad Dip Med Lab Sci
Research assistant Belinda Trajkovska BA, PG DIP Psych
Research student Stephanie Cohen
Nursing research staff Elizabeth Josland CNC, Dip Nurs, MPH Tania Burns CNC, Grad Cert. Nurs Alison Smyth BNurs
2. Research Grants
Australia New Zealand Society of Nephrology (ANZSN)/AMGEN; 2009-2010: $10,000 Models of Care project Burns, T, Smyth A, Tranter S.
Renal Research Fund – Wits Foundation – University of the Witwatersrand; 1999 – 2009: R 500 000.00 – A$76000 Chronic Disease Outreach Program (South Africa) Dr Ivor Katz.
48 Unrestricted Grant to Renal Research Fund – Wits Foundation and Wits Consortium – University of the Witwatersrand; 2005 – 2009: R 120 000.00 – A$18000 BART (Bara Renal Tracking System) South Africa Dr Ivor Katz
Directed Grant to Renal Research Fund – Wits Foundation– University of the Witwatersrand; 2005 – 2009: R 140 000.00 – A421000 Chronic Diseases Fellowship Training Dr Ivor Katz.
Rosebank Rotary Club; a grant to enable us to send South African Nurses to train in Australia to develop skills for chronic illness management training including hypertension, diabetes and kidney disease
Directed Grant to Renal Research Fund – Wits Consortium– University of the Witwatersrand 2007- 2009: R 400 000.00/year – A$60000 Fresenius Nephrology Training Fellowship Dr Ivor Katz
3. Research Projects in Progress
1. Retrospective and prospective studies of the effects of a Renal Palliative care service on patients with CKD stage 4/5 and their carers Chief Investigator: Prof Mark Brown
2. The Renin-angiotensin system in pre-eclampsia Chief Investigator: Prof Mark Brown
3. Methods of measuring blood pressure in normal and hypertensive pregnancies Chief Investigator: A/Prof G Mangos & Prof Mark Brown
4. Study of Heart and Renal Protection (St. George Institute and Oxford University) Chief Investigator: A/Prof John Kelly
5. Non-invasive haemodynamic assessment of central and peripheral blood pressure in chronic kidney disease. Chief Investigator: A/Prof John Kelly
6. Honey Pot Trial (Australian Kidney Trials Network) Chief Investigator: Dr Sharon Ong
7. Masked Hypertension in Chronic Kidney Disease, Dialysis and Renal Transplant patients. Chief Investigator: Dr Sharon Ong
49 8. Evaluation of Referral of patients with Kidney and Cardiovascular Disease to St George Hospital Chief Investigator: Dr Ivor Katz
9. Development of a Chronic Disease Outreach Program which includes a Kidney and Cardiovascular early detection and management system for St George Hospital and its area health service. Chief Investigator: Dr Ivor Katz
10. Models of Care Project Chief Investigators: Tania Burns and Alison Smyth
4. Original Peer - Reviewed Publications
Brown MA, Lowe SA. Current management of pre-eclampsia. MJA. 2009; 190:3-4.
Lane CA, Brown MA. Nephrology: A specialty in need of resuscitation? Kidney Int. 2009; 76:594-6.
Kho L, Brown MA, Ong SLH, Mangos G. Blood pressure measurement in pregnancy: the effect of arm circumference and sphygmomanometer cuff size. Obstet. Med. 2009; 2: 116-120.
Lowe SA, Brown MA, Dekker G, Gatt S, McLintock C, McMahon L, Mangos G, Moore MP, Muller P, Peek M, Walters B. Guidelines for the management of hypertensive disorders of pregnancy. ANZJOG. 2009; 49: 242-6
Mangos GJ. Investigation of the patient with Hypertension. Medical Today December 2009 Vol 10 Number 12.
Zhang Y, Wu JHY, Vickers JJ, Ong SLH, Temple SEL, Mori TA, Croft KD, Whitworth JA. The role of 20-hydroxyeicosatetraenoic acid in glucocorticoid-induced hypertension. J Hypertens 2009; 27(8): 1609-1616.
Ong SLH, Zhang Y, Sutton M, Whitworth JA. Haemodynamics of dexamethasone-induced hypertension in the rat. Hypertens Res 2009; 32(10): 889-894.
50 Ong SLH, Zhang Y, Whitworth JA. Mechanisms of dexamethasone-induced hypertension. Curr Hypertens Rev 2009; 5(1): 61-74.
Katz I, Schneider H, Shezi Z, Mdleleni G, Gerntholtz T, Butler O, Manderson L and Naicker S. Managing Type 2 Diabetes in Soweto – the South African Chronic Disease Outreach Program Experience. Primary Care Diabetes. 2009 (3): 157-164
5. Other published material
Brown MA Foreword. in: Talley N, O’Connor S (eds) Examination Medicine 6th edition. Elsevier. 2009
6. Presentations at Scientific Meetings/Conferences
International
1. Brown MA. Pre-eclampsia and the Kidney. Weill Cornell Medical College Nephrology Grand Rounds. New York. USA. Oct 22nd 2009.
2. Kelly JJ. Buckley A, Colagiuri R on behalf of Ministry of Health Vanuatu, Ministry of Health Nauru, World Diabetes Foundation, Australian and New Zealand Society Nephrology, Australian Health Policy Institute Diabetes Unit. Risk factors for Nephropathy in diabetic subjects in the South Pacific: Baseline data from capacity building projects in Vanuatu and Nauru. International Congress of Nephrology. Milan Italy, May 2009.
3. Mangos GJ. A comparison of Singleton Vs Twin Hypertensive pregnancies. Poster Presentation at International Conference on Twin Pregnancy, Venice Italy April 2009
4. Katz I. “HIV and Kidney Disease: The other side of the coin” and “Early Prevention and Detection Strategies for Chronic Kidney Disease in Minority Groups and Developing Countries” Invited speaker at World Congress of Nephrology, Milan; Italy 2009.
5. Ram JL, Brown MA, Mangos GJ. Effect of cuff size on automated BP measurement. Oral presentation by Ms Ram at SOMANZ Annual Scientific Meeting. Auckland NZ 2009 (Young Investigator Award Winner).
51 National
1. Brown MA. What is new in Pre-eclampsia? Nephrology Update meeting. 45th Annual Scientific Meeting. ANZSN Hobart, Tasmania. Sept 5th 2009.
2. Josland E, Tranter S, Brennan F, Brown MA. Quality of Life (QoL) in St. George Dialysis Population. Renal Society of Australasia. Rotorua: NZ 2009.
3. Brown MA. Management of end stage renal failure – the importance of palliative care. Sydney Institute of Palliative Medicine. 18th Annual Symposium Sydney. NSW. April 3rd 2009.
4. Shanmugasundaram P, Brown MA. Pulse wave analysis and ultrasound evaluation of the inferior vena cava in hemodialysis patients. ANZSN 45th Annual Scientific Meeting. Hobart. Sept 7-9. 2009
5. Ong SLH, Sutton M, Zhang Y, Whitworth JA. Haemodynamics of dexamethasone-induced hypertension in the rat. Oral presentation at the Australian Society of Medical Research, Australian Capital Territory Young Investigator Forum, Canberra, 2009.
6. Ong SLH, Sutton M, Zhang Y, Whitworth JA. Haemodynamics of dexamethasone-induced hypertension in the rat. Poster presentation at the Australian and New Zealand Society of Nephrology, Hobart, September 2009.
7. Ritchie A, Ong SLH. An unusual presentation of primary aldosteronism: rhabdomyolysis with acute renal failure. Poster presentation at the Australian and New Zealand Society of Nephrology, Hobart, September 2009.
8. Lane C. The Australian Nephrology workforce surveys- results and implications. Dialysis, Nephrology and Transplantation (DNT) conference. Lorne. Victoria (Aust), March 2009.
Local
1. Brown MA. Management of diabetic nephropathy. Endocrinology Seminars. Dept. Endocrinology. Royal Prince Alfred Hospital. Sydney. 29th April.2009
52 7. Community Engagement
1. Brown MA. Postgraduate research and career planning. ‘Kidney School’. NSW Nephrology Training Program 2009. Sydney. NSW. 8/4/09
2. Brown MA. Renal Palliative Care. Dept Renal Medicine. Royal North Shore Hospital. 18th Nov. 2009 3. Brown MA. Obstetric Medicine. Algesal FRACP Course. Royal Prince Alfred Hospital. Sydney. 05/12/09.
4. Mangos GJ. An Unwanted Surprise in Pregnancy. Presentation to Advanced trainees in Renal Medicine 2009, Kidney School, NSW Nephrology Training Program 2009. Sydney
5. Mangos GJ. Chronic Kidney Disease. GPCE Meeting May 2009 SYDNEY
6. Mangos GJ. Renal Angiography, A Nephrologist’s Perspective. Invited Speaker Abbott Vascular Renal Workshop, Wollongong 2009
7. Ong SLH. Hypokalaemic rhabdomyolysis secondary to primary hyperaldosteronism. NSW Renal Group Meeting, Sydney 2009.
53 DEPARTMENT OF RESPIRATORY MEDICINE & SLEEP DISORDERS
1. Departmental Staff
Head of Department Dr Steven Lindstrom MBBS, FRACP
Senior Medical Staff Dr Andrew Ng MBBS, FRACP, Ph.D. (Sutherland Hospital) Dr Elizabeth Clark MBBS, FRCP (U.K.) Dr Con Archis MBBS, FRACP (Sutherland Hospital) Dr John Moses MBBS, FRACP (St George Private)
Staff Specialists Dr Frank Yan MBBS, FRACP (Aged Care DepT) Dr Veronica Yozghatlian MBBS, FRACP (RPAH- Cystic Fibrosis Clinic)
Visiting Medical Officers Dr Hazel Goldberg MBBS, FRACP (POW & Sydney Hospitals)
Junior medical staff Advanced trainees Dr Eric Wong MBBS Dr Irshad Ali MBBS
Research Staff Senior research staff Jay Flack BSc Research assistants Carol Gano MND Nursing research staff Cyndy Higgins BA
54 2. Research Projects in Progress
Procalcitonin in Community Acquired pneumonia Dr Eric Wong, Dr Steven Lindstrom
Surgery on Obesity Sleep Apneoa Dr Eric Wong, Dr Steven Lindstrom
Venous Blood Gas in COPD patients with Non-Invasive Ventilation Dr Eric Wong, Dr Andrew Ng
Audit of the Care of Patients with Tuberculosis at St George Hospital Dr Irshad Ali, Dr Hazel Goldberg
3. Community Engagements
Jay Flack – Spirometry Application and Interpretation Presentations and Lectures- 4 sessions over the year
Dr Steven Lindstrom –Chronic Obstructive Pulmonary Disease presentation World Chronic Obstructive Pulmonary Disease Day - 5 November 2009
55 DEPARTMENT OF RHEUMATOLOGY
1. Departmental Staff
Head of Department Associate Professor Allan Sturgess MB.BS (UQ), PhD (Melb), FRACP, FRCPA Senior Staff Specialist, Conjoint Associate Professor of Medicine, UNSW
Senior Medical Staff Professor Marissa Lassere MB.BS (Hons) (Syd), PhD (UNSW), Grad Dip Epi (Newcastle) FRACP, FAFPHM Senior Staff Specialist, Conjoint Professor of Medicine, UNSW Professor
Professor Bruce Kirkham MB ChB MD FRACP (January – September 2009) Professor of Rheumatology, UNSW, Consultant Rheumatologist
Dr Bill Giannakopoulos (from October 2009) BSci.(Med), MBBS (UNSW), PhD(UNSW), FRACP Senior Lecturer in Medicine, UNSW, Consultant Rheumatologist
Dr Ian Portek MBBS (Syd), FRACP VMO Rheumatology, Senior Lecturer in Medicine, UNSW
Dr Lou McGuigan MBBS (UNSW) MD (UNSW) FRACP, VMO Rheumatology
Junior Medical Staff Dr Jane Oliver (Advanced Trainee in Rheumatology)
Rheumatology Fellow Sargunan Sockalingam MBBS, MMed
Senior Research Staff Dr Kent Johnson BA(Harvard) BA(Oxford) MD (John Hopkins) Senior Lecturer in Medicine, UNSW
Research Staff Joy Rappo BNursing MSc RN Rosemarie van den Haak Dr Rowena Forsyte BA (Hons) (Syd) PhD (UNSW) Carol Maddock MA Mark Broadbent Sue Baker BAppSc (Biomed) (UTS) Tanya Thompson BSc (UNSW) Michal Schiff BSc, MSc.Associate Lecturer in Medicine
56 Margaret Karr MPH (UW), MSc(Med)(USyd) Darssan Balasingam BSc MBiostatistics Thomas Suesse MSc (FSU) PhD (VUW) Lecturer in Medicine Chris Pardy BSc(Hons) (Syd) MStatistics (UNSW)
Research Consultants Dr Andrew Parle BSc (Hons)(Syd) PhD (Syd)
Research students Qi (Mervyn) Po ILP Student Steve Lazar BMedSs
Nursing Research Staff Ms Wendy Gellately RN,
Research Allied Health Hinchey G Grad Dip Sports (Germany), Grad Dip Physio (Germany) Brand C BSci (Anatomy) PostGrad Dip Physio Uptin W BPhysio
2. Research Grants
National, peer reviewed:
NHMRC Enabling Grant 384330; 2006-2010: $1,250,000. Australian Rheumatology Association Database. Buchbinder R, March L, CIC Lassere MN, Reid C
NHMRC Project Grant 455467; 2007 – 2011: $665,500 Electronic portable health file (PHF) to promote quality of care and workflow through continuity of care. Lassere MN, Sara T, Johnson K, Iedema R, Rubin G, Macauley V
NHMRC Project Grant 510272; 2008 – 2010: $510,00 Levels of evidence for surrogate therapeutics Lassere MN, Johnson KR, Dunsmuir W, Galbraith S, Ward R, Hughes M.
Other funding: St George Medical Research Foundation New Investigator Grant 2009: $20,000 Investigations Into The Modulatory Activity Of B2GPI on Coagulation In Vitro And In Vivo Bill Giannakopoulos.
57 3. Research Projects in Progress
Predictors of cardiovascular mortality and morbidity in rheumatoid arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Rappo J, McGuigan L
The role of informal carers in patients with arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Rappo J
Secular changes in health-related quality of life over two decades in patients with rheumatoid arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Rappo J
A longitudinal analysis of determinants of physical, psychological and social well-being in patients with arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Rappo J, McGuigan L
Health care utilization and out-of-pocket costs in patients with rheumatoid arthritis. Lassere M, Rappo J, Johnson K
Incidence, prevalence and predictors of malignancy in patients with rheumatoid arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Rappo J, McGuigan L
Health-related quality of life in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Staples M, Buchbinder R, Reid C, Lassere M, March L.
Prevalence and predictors of all-cause hospitalization in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Williams B, Lassere M, March L, Buchbinder R, Reid C. Chand V, Hay N
Incidence and predictors of tuberculosis in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Williams B, Lassere M, March L, Buchbinder R, Reid C, Henderson L, van den Haak R, Staples M, McPhee J
An evaluation of health status, quality of life and adverse events of children on biologic treatment for juvenile arthritis. Akikusa J, Buchbinder R, Reid C, Lassere M, March L, Williams M, Henderson L, Staples M, McPhee J
Cardiovascular morbidity in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Van Doornum S, Buchbinder R, Reid C, Lassere M, March L, Williams M, Staples M,
Incidence and predictors of malignancy in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Williams M, Buchbinder R, Reid C, Lassere M, March L, Karr M, Henderson L, van den Haak R, Staples M, McPhee J
Why patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis switch biologic agents. Williams M, Buchbinder R, Reid C, Lassere M, March L, Staples M
58 Tolerability and adverse events of leflunomide, leflunomide-DMARD and leflunomide -biological combination treatment in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Mourad J, Lassere M, March L, Buchbinder R, Reid C.
The responsiveness of computer-based methods for measuring joint damage progression in subjects with rheumatoid arthritis. Po M, Bird P, Lassere M, Edmonds J
Comparison of computer-based methods with scoring methods for joint space narrowing in subjects with rheumatoid arthritis. Po M, Bird P, Lassere M, Edmonds J
Evaluating the measurement properties of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for evaluating disease activity and damage progression. Bird P, Lassere M, Ostergaard M, Conaghan P, McQueen F.
Evaluating the measurement properties of the Psoriatic Arthritis Magnetic Resonance Imaging Score (RAMRIS) for evaluating disease activity and damage progression. Bird P, Lassere M, Ostergaard M, Conaghan P, McQueen F.
The evaluation of knee articular cartilage in osteoarthritis using Magnetic Resonance Imaging. Lassere M, Oakley M.
The reliability and validity of Power Doppler ultrasound in patients with rheumatoid arthritis. Joshua F, Lassere M.
Methods for the development and use of quality indicators for improving patient care and for professional development. Lassere M
Development and implementation of a national set of Rheumatoid Arthritis Quality indicators. Lassere M, Johnson
Development and evaluation of the Tolerability and Safety Questionnaire (TASQ): a patient-self report instrument of treatment related tolerability and safety for use in all-disease clinical trials. Lassere M, Johnson K
The development of the Tolerability and Safety Index (TASI): a summary single score measure of the ascertainment and reporting of tolerability and safety for indirect trial comparisons, meta-analysis of clinical trials and the evaluation of risk/benefit.for clinical and economic modeling. Lassere M, Johnson K, Finteln S, Rappo J, Balasingam D, Day R, Tugwell P, Anderson J
Qualitative studies of the attitudes, perceptions and opinions about the methods used to ascertain and report adverse events in clinical research by patients, health professionals, pharmaceutical industry, regulators, medical editors, health administrators and health payers. Lassere M, Forsyth R, Iedema R, Maddock C, Johnson K
A clinical audit of the use of VTE guidelines in a teaching hospital. Lazar S, Chapman, Chong B, Lassere M, Fry M.
59 A qualitative study of the attitudes and barriers of venous thromboembolic (VTE) prevention in medical and nursing personnel. Lazar S, Chapman, Chong B, Fry M, Lassere M.
Evaluation of changes in knee synovial membrane cytokine expression of IL-10, IL-1ß, IL-17, TNFα, IL-6, IFNγ, RANKL using qT-PCR in patients with rheumatoid arthritis. Kirkham B, Lassere M, Edmonds, Portek I.
Evaluation of a prognostic measure of rheumatoid arthritis damage progression using MRI, arthroscopy and synovial membrane analysis. Kirkham B, Lassere M, Bird P, Edmonds, Portek I.
Qualitative studies of the organisational, professional, sociocultural and technical factors influencing the effective use of a patient-held portable health file by patients, health care providers, government and information technology industry. Lassere M, Forsyth R, Iedema R, Maddock C,
An evaluation of the business, architectural, and workflow requirements of the patient held PHF and the health-care provider electronic medical record to understand the shared information resources required to support a collaborative care model. Lassere M, Iedema R, Sara T, Baker S, Rappo J, McCauley V, Stelter K, Rowling Y, Broadbent M.
The development of a synchronized and secure electronic patient-held portable health file (ePHF). Lassere M, Parle A,
The development of a paper patient-held portable health file (PHF). Lassere M, Maddock C, Rappo J
A randomised controlled trial to demonstrate the effectiveness, acceptability, and sustainability of a patient-held portable health file on improving health care delivery, clinician’s and patient’s decision-making processes, patient outcomes, and health services costs. Lassere M, Johnson K, Iedema R, Sara T, Rubin G, Baker S, Rappo J, McCauley V, Stelter K, Rowling Y , Broadbent M.
Evaluate the scientific, clinical, statistical, cultural, commercial and regulatory factors influencing the application of a levels of evidence schema for biomarkers and surrogate endpoints. Lassere M, Buyse M, Campbell T, Mitchell A, Berger V, Burzykowski T, Dunsmuir W, Galbraith S, Hughes M, Handel G, Grimm M, Johnson K
Evaluate the validity and feasibility of a levels of evidence schema for biomarkers and surrogate endpoints (BSES) in different medical conditions. Lassere M, Buyse M, Campbell T, Mitchell A, Berger V, Burzykowski T, Dunsmuir W, Galbraith S, Hughes M, Handel G, Grimm M, Johnson K
Investigate current statistical methods to advance biomarker and surrogate endpoint evaluation using simulated and real data sets that reflect limitations of data and statistical assumptions. Lassere M, Buyse M, Burzykowski T, Dunsmuir W, Galbraith S, Hughes M, Pardy C, Flack L, Johnson K
Consensus-building for the development of a standardised method of systematically quantifying the strength of the evidence that supports a biomarker’s claim to surrogacy for use in clinical trials. Lassere M, Johnson K
60 Developing reporting standards for clinical and biomarker measurement methods in medicine. Lassere M
A qualitative-quantitative evaluation of continuity of care handover in a Sydney teaching hospital. Lassere M
The evaluation of statistical methods including quantile regression for the development of chronic disease reference norms. Lassere M
Evaluate a by-trial regression model to estimate the surrogate threshold effect (STE) of blood pressure on stroke outcomes. Johnson K, Lassere M, Schiff M, Rees D.
Evaluate a by-trial regression model to estimate the surrogate threshold effect (STE) of bone mineral density on fracture outcomes. Johnson K, Lassere M
Evaluate a by-trial regression model to estimate the surrogate threshold effect (STE) of response rate and progression-free survival in renal cell carcinoma. Lassere M, Johnson K, Ward R
A systematic review of systemic lupus erythematosus lupus (SLE) trial design, validity and generalisability. Sockalingam S, Johnson K, Lassere M
An evaluation of meta-analysis in the presence of heterogeneity performance (bias, accuracy and coverage) with varying trial parameters (size, number, treatment effect, and variability) using simulations. Johnson K, Lassere M, Flack L.
The design and statistical analysis of reliability studies. Lassere M
Data requirements for validity in economic analyses of healthcare. Johnson KR, Lassere MN
Capturing the uncertainty of surrogate outcomes in cost-effectiveness models. Johnson KR, Lassere MN
A randomised controlled trial of a treat to target strategy versus usual care in patients with rheumatoid arthritis. Lassere MN, Johnson KR, Sturgess A, Portek I, Edmonds J, Bird P, Carlton K
Cytokines, chemokines and vascular mediators of disease activity and damage in rheumatoid arthritis. Lassere MN, Johnson KR, Thompson T, Edmonds J
Improving the predictive value of anti-phospholipid serology. Sturgess A
Detection and significance of membrane-bound light chains on B cells in SLE and RA. Sturgess A
61 Researching the in vivo role of beta 2-glycoprotein I in regulating lipid metabolism in autoimmunity. Bill Giannakopoulos, Klaus Matthaei, Kerry-Ann Rye, Steve Krilis. Researching the in vivo role of beta 2-glycoprotein I in regulating spontaneous autoimmune/ lupus responses. Bill Giannakopoulos, Robert Brink, Dominique Gatto, Chris Weatherill, Derek Spielman, Steve Krilis.
Researching the in vivo role of beta 2-glycoprotein I in driving the autoimmune response in the generation of anti-beta 2-glycoprotein I autoantibodies. Bill Giannakopoulos, Steve Krilis.
Researching the in vivo role of beta 2-glycoprotein I in innate immunity. Bill Giannakopoulos, Steve Krilis.
A prospective international multicentre study examining the predictive and diagnostic role of novel ELISAs detecting oxidative post-translational modifications of B2GPI. Bill Giannakopoulos, Steve Krils, Stephane Heritier
The role of thiol-exchage reactions in the regulation of factor XI activity. Bill Giannakopoulos, Steve Krilis.
Examination of the factors involved in nurturing creative thinking in physician-scientists undertaking basic scientific research. Bill Giannakopoulos
Evaluation and management of lateral hip pain. Hinchey G, Brand C, Uptin W
4. Original Peer-Reviewed Publications
Chatfield SM, Wicks IP, Sturgess AD, Roberts L. Anti-citrullinated peptide antibody: death of the rheumatoid factor. Medical Journal of Australia. 2009, 190(12) 693-695.
Morgan PE, SturgessAD, Davies MJ Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. Free Radical Research 2009; 43(2):117-27,
Johnson K, Freemantle N, Anthony D, Lassere MN. LDL-cholesterol differences predicted survival benefit in statin trials by the surrogate threshold effect (STE). Journal of Clinical Epidemiology. 2009. 62:328-336.
McQueen F. Lassere M. Duer-Jensen A. Wiell C. Conaghan PG. Gandjbakhch F. Hermann KG. Bird P. Boyesen P. Peterfy C. Ejbjerg B. Haavardsholm EA. Coates L. Ostergaard M. Testing an OMERACT MRI scoring system for peripheral psoriatic arthritis in cross-sectional and longitudinal settings. J Rheumatol. 2009;36(8):1811-5.
62 Ostergaard M. Conaghan PG. O’Connor P. Szkudlarek M. Klarlund M. Emery P. Peterfy C. Genant H. McQueen FM. Bird P. Lassere M. Ejbjerg B. Reducing invasiveness, duration, and cost of magnetic resonance imaging in rheumatoid arthritis by omitting intravenous contrast injection - does it change the assessment of inflammatory and destructive joint changes by the OMERACT RAMRIS? J Rheumatol. 2009;36(8):1806-10.
Ostergaard M. McQueen F. Wiell C. Bird P. Boyesen P. Ejbjerg B. Peterfy C. Gandjbakhch F. Duer- Jensen A. Coates L. Haavardsholm EA. Hermann KG. Lassere M. O’Connor P. Emery P. Genant H. Conaghan PG. The OMERACT psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS): Definitions of key pathologies, suggested MRI sequences, and preliminary scoring system for PsA hands. J Rheumatol. 2009;36(8):1816-24.
Conaghan PG. Bird P. McQueen F. Peterfy C. Boyesen P. Gandjbakhch F. Duer-Jensen A. Haavardsholm EA. Ejbjerg B. Wiell C. Coates L. Hermann KG. O’Connor P. Lassere M. Freeston JE. Anandarajah A. Genant H. Emery P. Ostergaard M. The OMERACT MRI inflammatory arthritis group: Advances and future research priorities. J Rheumatol. 2009;36(8):1803-5.
Oldroyd J. Schachna L. Buchbinder R. Staples M. Murphy B. Bond M. Briggs A. Lassere M. March L. Ankylosing Spondylitis Patients Commencing Biologic Therapy Have High Baseline Levels of Comorbidity: A Report from the Australian Rheumatology Association Database. International J Rheumatol 2009, Article ID 268569, 10 pages doi:10.1155/2009/268569
Briggs AM. March L. Lassere M. Reid C. Henderson L. Murphy B. van den Haak R. Rischin A. Staples M. Buchbinder R Baseline Comorbidities in a Population-Based Cohort of Rheumatoid Arthritis Patients Receiving Biological Therapy:Data from the Australian Rheumatology Association Database. International J Rheumatol. 2009, Article ID 861481, 8 pages doi:10.1155/2009/861481
Briggs A, March L, van der Haak R, Lassere M, Buchbinder R.. Stakeholder Satisfaction with the Australian Rheumatology Association Database (ARAD) The Patient 2009 2(1) 1-8.
Evans, H. G.; Gullick, N. J.; Kelly, S.; Pitzalis, C.; Lord, G. M.; Kirkham, B. W., and Taams, L. S. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Nat Acad Sci. 2009; 106(15):6232-7.
Humby, F.; Bombardieri, M.; Manzo, A.; Kelly, S.; Blades, M. C.; Kirkham, B.; Spencer, J., and Pitzalis, C. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Medicine / Public Library of Science. 2009; 6(1):e1.
63 Macedo, A.; Oakley, S.; Gullick, N., and Kirkham, B. An examination of work instability, functional impairment, and disease activity in employed patients with rheumatoid arthritis. Journal of Rheumatology. 2009; 36(2):225-30.
Macedo, A. M.; Oakley, S. P.; Panayi, G. S., and Kirkham, B. W. Functional and work outcomes improve in patients with rheumatoid arthritis who receive targeted, comprehensive occupational therapy. Arthritis & Rheumatism. 2009; 61(11):1522-30.
Wong, M.; Oakley, S. P.; Young, L.; Jiang, B. Y.; Wierzbicki, A.; Panayi, G.; Chowienczyk, P., and Kirkham, B. . Infliximab improves vascular stiffness in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. 2009; 68(8):1277-84.
Joanne H Reed, Bill Giannakopoulos, Michael W. Jackson, Steven A Krilis and Tom P Gordon. Ro 60 functions as a receptor for beta2-glycoprotein I on apoptotic cells: Beta2-glycoprotein I masks a Ro 60 apotope. Arthritis Rheum. 2009; 60: 860-869.
5. Other published material
Giannakopoulos B, Passam F, Ioannou Y, Krilis SA. How We Diagnose The Antiphospholipid Syndrome. Blood, 2009; 113; 985-94 (Invited Review).
Giannakopoulos B, Krilis SA. How I Treat The Antiphospholipid Syndrome. Blood. 2009; 114:2020-30 (Invited Review)
6. Presentations at Scientific Meetings/Conferences
International
Marissa Lassere. Levels of evidence for biomarker-surrogate therapeutics. Biomarker-Surrogate Evaluation Schema (BSES): a multidimensional hierarchical schema. National Institute of Clinical Excellence (NICE) London. 2/10/09
Marissa Lassere. Levels of evidence for biomarker-surrogate therapeutics. Biomarker-Surrogate Evaluation Schema (BSES): a multidimensional hierarchical schema. University of Hasselt (Deipenbeek, Belgium) 8/10/09
64 Marissa Lassere. Use of patient-held paper and electronic portable health files (PHFs) to facilitate reliable health knowledge transfer among healthcare providers and patients. International Society for Quality in Health Care International meeting. Dublin 12/10/09
Kent Johnson. National Institute of Clinical Excellence (NICE) London. 2/10/09 – The surrogate threshold effect: Ten clinical scenarios
National Allan Sturgess. Interpretation of tissue antibodies (SMA, AMA, LKM). Immunopathology Training Program. Westmead Hospital. 10/05/2010
Marissa Lassere. The Shared Electronic Health Record. Roche Annual Symposium on Rheumatology. 22/02/09 Sydney
State Allan Sturgess. Transition model for adolescents with developmental disability. Presented at Forum on Mental Disorders in Children and Adolescents with an Intellectual Disability. Sydney 24/09/2010
Oliver J, Zomor Z, Issacs J, Sturgess. Subtrochanteric femoral fractures and bisphosphonate therapy: biochemical and patient factors. Australian RheumatologyAssociation Scientific State Meeting. Best clinical presentation. 28/11/09 Hunter Valley.
St George Hospital Bill Giannakopoulos First prize for best basic science oral presentation at the 2009 St George Hospital Medical Symposium
7. Community Engagement
Allan Sturgess is Hon. Patron “The Myositis Association – Australia Incorporated”.
Marissa Lassere. Talk on Arthritis and Rheumatism. Hurstville Rotary Club. 3/8/09.
Marissa Lassere. Member of Surrogate to Final Outcome Working Group. Department of Health and Ageing Pharmaceutical Benefits Advisory Committee (PBAC), Canberra
Marissa Lassere. Chair, Quality and Safety, Australian Rheumatology Association
Marissa Lassere. Member. Shared Scientific Assessment Committee NSW Health
65 SURGERY, PERIOPERATIVE CARE & CANCER
DEPARTMENT OF CARDIOTHORACIC SURGERY
1. Departmental Staff
Head of Department Dr Gary Fermanis MB.B.S (Hons) FRACS
Senior Consultant Staff Dr Matthew Horton MB.B.S FRACS (Visiting Medical Officer) Dr Con Manganas MB.B.S FRACS (Visiting Medical Office)
Junior Medical Staff Dr Sheen Peeceeyen MS, MCh (Cardiothoracic Surgery) Dr Takeshi Uzuka MBBS, PhD Dr Sreeja Swamidas MCh (DNB National Board Cardiothoracic) Dr Ajay Hiirakannawar MCh (Cardiothoracic Surgery)
2. Research Projects in Progress
1. Comparative assessment of the On-X Prosthetics Heart Valve against St Jude Medical, Carbomedics and Medtronic Heart Valves in the aortic position : A prospective randomized clinical study.
2. A prospective controlled group study to assess the efficacy of Navigator versus conventional care in post-operative cardiac surgery patients.
3. Multicentre FREEDOM trial comparing stenting with surgery in multi vessels disease.
4. Reduction in intra-pericardial adhesions using a bioabsorbable membrane: a large animal model. (For Masters of Surgery by Research. Dr Con Manganas, UNSW).
66 3. Original Peer-Reviewed Publications
Yan T , Chua D, Yap Z, Horton M, Fermanis G and MorrisD Thoracic Cytoreductive Surgery and Intraoperative Hyperthermic Intrathoracic Chemotherapy for Pseudomyxoma Peritonei. . Journal of Surgical Oncology 2009;00:1-5
Rathorne K, Cooper M, Manganas C. Limited Exclusion of a Right Atrial Lipoma. Heart Lung Circulation 2009 Oct; 18(5): 370-71.
4. Presentations at Scientific Meetings / Conferences
Participation in national cardiac database (ASCATS) funded by Clinical Excellence Commission
Transoesophageal Echocardiogram Evaluation on Internal Mammary Artery Flow pre and post coronary by-pass grafting. Lee R, Pybus D Poster presentation at Annual Scientific Cardiothoracic Meeting, Noosa, Qld.
5. Community Engagement
Knights of St George Ball – community fund raiser, supported by ex-patients, held at Penshurst RSL on two occasions in July and November 2009. Proceeds used to purchase new heart / lung machine, intra aortic balloon pump.
67 DEPARTMENTS OF GASTROINTESTINAL SURGERY UPPER GASTROINTESTINAL SURGERY
1. Departmental Staff
Head of Department Dr Michael L Talbot. FRACS MB ChB. UNSW Conjoint Senior Lecturer in Surgery
Senior Medical Staff Dr John O Jorgensen, FRACS MBBS (VMO) Dr Ken W Loi, FRACS MBBS (VMO) Dr Vytauras Kuzinkovas, MBBS MD MRCSEd FRCSEd FRACS (VMO)
Clinical Associates Dr Phillip Seely MBBS Dr Georgia Rigas MBBS FRACGP
Surgical Fellows Dr James Chau, MBBS FRACS Dr Ben Woolven, MBBS FRACS
Research Staff Ana Borbajo RN Tania Matisan RN
Gastrointestinal Motility Laboratory Supervisor Debra Parsons RN
Research student Ms Evyenia Panos UNSW Medical Student
2. Research Grants
Other funding
Vibrynt Medical USA, Mobius Medical Australia. Laparoscopic Placement of a Paragastric Implant for Morbid Obesity. Michael Talbot.
Cavu Medical USA. A Prospective, Multi Centre Clinical Evaluation to Observe the Intra Band Pressure Variances in Newly Implanted Laparoscopic Adjustable Gastric Bands (LAGB) Between Adjustments. Michael Talbot
68 3. Research Projects in Progress
Changes in Metabolic Rate and Body Composition and Metabolic Rate after Weight Loss Surgery. Dr Michael Talbot, Evy Panos, Dr Georgia Rigas, Dr Phillip Seely, Dr Vytauras Kuzinkovas.
Indications and Outcomes of Re-operative Bariatric Surgery in 220 Patients. Dr Ben Woolven, Dr Michael Talbot.
Long Term Outcomes in Diabetic Patients Undergoing Weight Loss Surgery. Dr Georgia Rigas, Dr Susan Gan. Dr Michael Talbot. Dr John Jorgensen. Dr Ken Loi.
Utility of Sleeve Gastrectomy following failed Laparoscopic Gastric Banding for Morbid Obesity. Dr James Chau, Dr John Jorgensen, Dr Michael Talbot, Dr Ken Loi.
Laparoscopic Placement of a Paragastric Implant for Morbid Obesity. Dr Michael Talbot, Dr Georgia Rigas, Tania Matisan.
A Prospective, Multi Centre Clinical Evaluation to Observe the Intra Band Pressure Variances in Newly Implanted Laparoscopic Adjustable Gastric Bands (LAGB) Between Adjustments. Dr Michael Talbot, Dr Georgia Rigas, Dr Phillip Seely, Tania Matisan.
4. Original Peer - Reviewed Publications
Babor, Richard; Talbot, Michael; Tyndal, Anthony Treatment of Upper Gastrointestinal Leaks With a Removable, Covered, Self-expanding Metallic Stent. Surg Laparosc Endosc Percutan Tech 2009;19:e1–e4
C. S. H. Lim, V. Liew, M. L. Talbot, J. O. Jorgensen and K. W. Loi. Revisional Bariatric Surgery. Obesity SURGERY 2009; 19:827 - 832
5. Presentations at Scientific Meetings/Conferences
National Conveners, Laparoscopic Sleeve Gastrectomy Workshop. John Jorgensen, Ken Loi, Michael Talbot.
Michael Talbot. Controversies in Reflux. Sydney Upper Gastrointestinal Surgical Society Meeting. March 2009.
Vytauras Kuzinkovas. A Complex UpperGI problem” Australian and New Zealand Gastro- oesophageal Surgery Society (ANZGOSa) meeting October 2009
69 LIVER SURGERY (see UNSW Dept of Surgery, Liver and Peritonectomy Unit)
COLO-RECTAL SURGERY
1. Departmental Staff
Head of Department David Z. Lubowski FRACS
Senior Medical Staff Denis W. King OAM FRACS D. Shevy Perera FRACS Steven Gan FRACS Daniel Kozman FRACS V Patton RN (CNC Anorectal Physiology Dept)
2. Research Projects in Progress
Predictive factors for anal incontinence in women who experience obstetric anal sphincter injury Vicki Patton, Emmanuel Karantanis, Kate Gardner, Katrina Parkin Project Outline: Prospective study examining women who have obstetric anal sphincter injury after vaginal delivery, compared with matched controls.
Patients with constipation and faecal incontinence Vicki Patton, Denis King, Phillip Dinning Project Outline: Prospective observational study to examine the characteristics of patients with dual symptoms of constipation and incontinence.
Long term follow-up of patients with cutting seton for anal fistula Vicki Patton, David Lubowski, Chung Min Cheng Project Outline: Follow-up of patients who have had cutting seton for complex anal fistula, examining clinical outcome, continence scores, quality of life and satisfaction with procedure.
Clinical outcomes of sacral nerve stimulation for treatment of faecal incontinence David Lubowski, Vicki Patton Project Outline: Follow-up of patients who have had insertion of sacral nerve stimulator examining clinical outcome, continence scores, quality of life and satisfaction with procedure.
70 Follow-up of patients who have had insertion of Chait Cecostomy Catheter for administration of antegrade colonic enemas for bowel management Vicki Patton, David Lubowski Project Outline: Follow-up of patients who have had insertion of Chait cecostomy for bowel management. The study examines clinical outcome, patient practises with irrigation technique, quality of life and satisfaction with procedure.
High resolution fiberoptic colonic manometry to examine the effect of sacral nerve stimulation on colonic movement in patients with faecal incontinence Vicki Patton, Phillip Dinning, Ian Cook, David Lubowski, John Arkwright (CSIRO) Project Outline: To study the impact of sacral nerve stimulation on colonic wave patterns in people with faecal incontinence using high resolution fibre optic manometry catheter in patients with faecal incontinence and constipation
3. Original Peer - Reviewed Publications
Mackey P, Mackey L, Kennedy ML, King DW, Newstead GL, Douglas PR, Lubowski DZ. Postanal repair – do the long-term results justify the procedure? Colorectal Disease 2009; 12 (4): 367–372
Liu L, Shang F, King DW, Lubowski DW, Burcher E. Cyclooxygenase-dependent alterations in Substance P-mediated contractility and NK1 receptor expression in the circular muscle of patients with slow transit constipation. J Pharmacol Exp Ther. 2009 ;324(1):170-8
4. Other published material
Lubowski DZ, Kennedy ML . Anorectal physiology. In: Pelvic Floor Re-education – Principles and Practice (Eds Baessler,Schussler, Burgio,Moore, Norton, Stanton), Springer-Verlag, London 2009, pp124-134
Lubowski DZ, Kennedy ML. Tests of Anorectal Physiology. In: Surgery of the Anus, Rectum and Colon, 3rd Ed (Keighley MRB, Williams NS, Eds.), Saunders Elsevier, London, 2009, pp12-45
5. Presentations at Scientific Meetings/Conferences
National D Z Lubowski ANZ Medical and Surgical Gastrointestinal Week, Darling Harbour, Sydney, 21-24 October 2009. “Surgical treatment of constipation”
71 DEPARTMENT OF NEUROSURGERY
1. Departmental Staff
Head of Department Dr Mark Davies MB.BS., FRACS (Conjoint Senior lecturer UNSW)
Senior Medical Staff Dr Bernard Kwok MB.BS., FRACS (Conjoint Senior Lecturer, UNSW) Dr Erica Jacobson MB., PhD, FRACS Dr Saeed Kohan MB.BS., FRACS Dt Warwick Stening MB.MS., FRACS, FRCS (Edin)
Junior Medical Staff Dr Ali Ghahreman MB.BS. Dr Peter Khong MB.BS Dr Ju Yong Cheong MB.BS Dr Vanessa Perotti MB.BS
2. Research Projects in Progress
Spine Wave Injectable Disc Nucleus SESAHS HREC. CTN SWP303 04/69. M.A.Davies (Coinvestigator)
A prospective randomized study comparing the use of Actifuse synthetic bone substitute with Infuse in patients requiring posterolateral instrumented lumbar fusion UNSW HREC 08060/UoW CT07/001 M.A.Davies (Coinvestigator)
Assessment of Dynamic Enhanced MRI in Brain tumours SESIAHS HREC ref: 08/stg/87 M.A.Davies (Coinvestigator)
3. Original Peer-Reviewed Publications
Sammons VJ, Jacobson E, Lawson J. Resolution of hydrocephalus-associated sensori-neural hearing loss after insertion of a ventriculo- peritoneal shunt J Neurosurg Pediatrics 2009; 4:394-6
72 4. Presentations at Scientific Meetings/Conferences
Sept 2009. Cervical disc arthroplasty in the treatment of spondylotic myelopathy and radiculopathy. P.Khong, A.Ghahreman, M.Davies Neurosurgical Society of Australasia ASM
June 2009, Lecture and live surgery on Minimally Invasive Neurosurgery, Beijing University 11th Hospital.
Nov 2009 Lecture on ‘delivery of neurovascular surgery in Sydney’ at the Hong Kong Stroke Society annual meeting.
73 DEPARTMENT OF ORTHOPAEDIC SURGERY
1. Departmental Staff
Head of Department Dr Wayne Viglione
Orthopaedic Surgeons Dr Robert Molnar, Lecturer (Conjoint) UNSW Prof Ian Harris Dr Paul Hitchen Dr Ashish Diwan- Senior Lecturer UNSW Dr Ron Sekel Dr Michael Dixon Dr SP Tan Dr Hugh Jones Prof George Murrell, Professor of Orthopaedic Surgery, UNSW Dr Zoltan Szomor, Senior Lecturer (Conjoint) UNSW, Medical Director of NSW Bone Bank
Junior Medical Staff Training Registrars: Dr Oliver Khoo, Dr David Broe, Dr Sarah Yong, Dr Yasser Khatib, Service Registrars: Dr Edmund O’Leary, Dr Charles Lai
Research Assistant Deanne Jenkin BSc, Clinical Research Manager (STG)
74 2. Research Projects in Progress
RB Molnar, The Journey TKA project: A comparison of two concepts for improved function of knee replacements.
RB Molnar, Screw Home Mechanism in Cruciate Retaining and Posterior Stabilized Total Knee Arthroplasty
RB Molnar, Prospective Randomised Pilot Study Comparing LCP (Locking Clavicle Plate) fixation with HCS (Headless Compression Screw), for the Treatment of Displaced Midshaft Clavicle Fracture.
RB Molnar, Radiostereometric Analysis (RSA), Of The Genesis II Minimally Invasive Surgery (MIS) Tibial Base Plate.
RB Molnar, Prospective randomised study comparing the dynamic hip screw and intramedullary gamma nail for the treatment of intertrochanteric hip fracture.
RB Molnar, To validate acetabular cup placement in total hip arthroplasty (THA) using CAS (computer assisted surgery).
RB Molnar, Safe zones for femoral tunnels in multi-ligament knee reconstruction.
RB Molnar, A pilot study to assess a multimodal approach to short stay arthroplasty.
RB Molnar, The Australian arthroplasty thromboprophylaxis survey.
Z Szomor, The effects of irradiation on the mechanical properties of tendon allograft tissue.
Z Szomor, Validation of bioburden reduction by gamma irradiation in bone allografts.
3. Original Peer-Reviewed Publications
Keeley A, Bloomfield P, Cairns P, Molnar R. Iliotibial band release as an adjunct to the surgical management of patellar stress fracture in the athlete: a case report and review of the literature. Sports Med Arthrosc Rehabil Ther Technol. 2009 Jul 30;1(1):15.
Gardner, Michael J; Osgood, Greg; Molnar, Robert; Chip Routt, Milton L Jr. Percutaneous Pelvic Fixation Using Working Portals in a Circumferential Pelvic Antishock Sheet. Journal of Orthopaedic Trauma 2009 23(9):668-674 2009.
IA Harris, A Dao, J Young, H Rae, B Jalaludin, M Solomon Predictors of patient and surgeon satisfaction after orthopaedic trauma Injury, 2009; 40(4): 377-84.
75 Harris IA, Dao A. Trends of spinal fusion surgery in Australia: 1997 to 2006 Aust NZ J Surg, 2009;79(11):783-8.
Naylor JM, Harmer AR, Heard RC, Harris IA. Patterns of recovery following knee and hip replacement in an Australian cohort. Aust Health Rev, 2009;33(1):124-35
Harris IA, Yong S, Harris AM. Surgical supervision. ANZ J Surg, 2009;79(6):418-20
Harris IA, Murgatroyd D, Cameron I, Young JM, Solomon MJ. The effect of compensation on health care utilisation in a trauma cohort Med J Aust, 2009; 190(11): 619-22
Kishen T, Harris IA, Diwan A. Primum non nocere and randomised placebo-controlled surgical trials: a dilemma? ANZ J Surgery, 2009;79(7/8)508-9
Adie S, Harris IA, Thorn L, McEvoy L, Naylor JM. Non emergency management of hip fractures in elderly patients Journal of Orthopaedic Surgery.2009;17(3):301-4
Adie S, Naylor J, Harris IA. Cryotherapy following total knee replacement Cochrane Database of Systematic Reviews 2009, Issue 4.
Adie S, Harris IA Critical evaluation: sliding hip screw or Gamma nail for hip fractures? Appraisal of a Cochrane review. ANZ J Surg. 2009;79(11):851-3.
Lin C, Fransen M, March L, Crosbie J, Crawford R, Graves S, Naylor J, Harmer A, Harris I, Jan S, Bennell K, Parker D, Moffet H. Maximum recovery after knee replacement - the MARKER study rationale and protocol BMC Musculoskeletal Disorders 2009, 10:69. http://www.biomedcentral.com/1471-2474/10/69
Harris IA. Getting the most out of internet searching. ANZ J Surg, 2009;79(5):317-8.
Harris IA. Trauma services in NSW. AOA Bulletin, 2009;30(2):18
76 Paoloni JA,Murrell GAC,Burch RM,Ang RY. Randomised, double blind, placebo controlled clinical trial of a new topical glyceryl trinitrate patch for chronic lateral epicondylosis. Br J Sports Med 2009 43 (4) 299-302.
Millar NL,Bradley TA,Walsh NA,Appleyard RC,Tyler MJ,Murrell GAC Frog glue enhances rotator cuff repair in a laboratory cadaveric model. J Shoulder Elbow Surg 2009; 18 (4) 639-45.
Millar NL,Wei AQ,Molloy TJ,Bonar F,Murrell GA. Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg (Br) 2009; 91 (3) 417-24.
Wu X,Baldwick C,Briggs L,Murrell GAC. Arthroscopic undersurface rotator cuff repair. Tech Shoulder Elbow Surg 2009; 10 (3) 112-8.
Millar NL,Wu X,Tantau R,Silverstone E,Murrell GAC. Open versus two forms of arthroscopic rotator cuff repair. Clinical Orthopaedics & Related Research 2009; 467 (4) 966-78.
Bradley T,Baldwick C,Fischer D,Murrell GAC. The effect of taping on the shoulders of AFL football players. Br J Sports Med 43 (10) 735-8.
Szomor ZL, Murrell GAC, Appleyard RC, Tyler MJ: Meniscal repair with a new biological glue: An Ex Vivo Study. Techniques in Knee Surgery 2009:7:261-5.
4. Other published material (books, book chapters, reviews,) (Not to include conf abstracts)
Murrell GAC,Wu X,Bandwick C Undersurface arthroscopic rotator cuff repair. American Academy of Orthopaedic Surgery DVD. 2009 Annual Meeting. Product no 19124, 9 minutes.
5. Presentations at Scientific Meetings/Conferences
National
RB Molnar, T Small. A pilot study to assess a multimodal approach to short stay arthroplasty. The Australian Orthopaedic Association annual meeting, Oct 2009.
77 RB Molnar, M Alfredson. To validate acetabular cup placement in total hip arthroplasty (THA) using CAS (computer assisted surgery). AOA NSW branch meeting, 2010. R Molnar, C-Spine in Intubated Patients. Austrauma, Feb 2010. Chandrasekaran S, Molnar RB. Minimally invasive imageless computer-navigated knee surgery: initial results. The AOA branch meeting, Hobart 2009.
RB Molnar, The Australian arthroplasty thromboprophylaxis survey. The AOA annual meeting, Oct 2009.
Shidiak L, Gan JH, Appleyard R, Gillies M, Molnar R. Angled screws as a method in reducing periprosthetic stress concentration. The AOA NSW branch meeting, 2010.
Predictors of patient and surgeon satisfaction after orthopaedic trauma. Alan Dao, Ian Harris, Jane Young, Bin Jalaludin, Michael Solomon Read at Annual Meeting of American Academy of Orthopaedic Surgeons Las Vegas, 24-28 February, 2009
Surgical management of hip fractures in older patients as non-emergent cases Sam Adie, Ian Harris, Lynette McEvoy, Lyndal Thorne, Justine Naylor Poster presentation at Annual Meeting of American Academy of Orthopaedic Surgeons Las Vegas, 24-28 February, 2009 Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009
Cryotherapy after total knee replacement: a systematic review and meta-analysis of RCTs Sam Adie, Justine Naylor, Ian Harris Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009
Predictors of outcome in orthopaedic trauma. Ian Harris Read at Austrauma 2009, Darling Harbour, Sydney, 12-14 February, 2009
Geriatricians are from Mars, Orthopaedic surgeons are from Venus. Ian Harris Read at Aged Care Network Orthogeriatric Symposium Sydney, 18 February, 2009
The effect of compensation on health care utilization in a trauma cohort. Ian Harris, Darnel Murgatroyd, Jane Young, Michael Solomon Poster presented at Annual Meeting of American Academy of Orthopaedic Surgeons Las Vegas, 24-28 February, 2009
Open tibia fractures: fixation options. Ian Harris Read at International Trauma Symposium Berlin, 7-8 May, 2009
Subtrochanteric non-unions. Ian Harris. Read at International Trauma Symposium Berlin, 7-8 May, 2009
Subtrochanteric insufficiency fractures associated with prolonged alendronate therapy. Joe Isaacs, Louis Shidiak, Ian Harris, Zoltan Szomor Read at AOA Annual Scientific Meeting Cairns, 11-15 October, 2009
78 Pulsed electromagnetic field stimulation for acute tibia fractures: initial results from a multicentre double blind randomized controlled trial. Sam Adie, Ian Harris, Hamish Rae, Sarah Yong, Alan Dao Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009 (winner of best paper prize) Read at AOA Annual Scientific Meeting (winner of Philip Segelov Award for best paper by a trainee) Cairns, 11-15 October, 2009
Non-operative treatment of patella fractures without splinting. Andrew Kanawati, Ian Harris, Sam Adie Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009 Read at AOA Annual Scientific Meeting Cairns, 11-15 October, 2009
Operative versus non-operative treatment for thoracolumbar burst fractures without neurological deficit: individual patient data meta-analysis. Sonali Gnanenthiran, Sam Adie, Justine Naylor, Ian Harris Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009 Read at AOA Annual Scientific Meeting Cairns, 11-15 October, 2009
Practice variation in common orthopaedic presentations: a survey of Australian orthopaedic surgeons. Umair Ansari, Sam Adie, Ian Harris. Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009 Read at AOA Annual Scientific Meeting Cairns, 11-15 October, 2009
Sliding hip screw or Gamma nail for extracapsular hip fractures? A re-analysis of a Cochrane review using individual patient data. Sam Adie, Ian Harris, Justine Naylor. Read at NSW AOA Annual Scientific Meeting Sydney, 21 August, 2009
The Australian Arthroplasty Thromboprophylaxis Survey. Michael Millar, Rob Molnar, David Campbell, Ian Harris. Read at AOA Annual Scientific Meeting Cairns, 11-15 October, 2009
Andres B, Lam P, Murrell GAC. (2009) Tension band rotator cuff repair biomechanically superior to double row repair? 76th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, February 25-28, 2009. Podium
Andres B, Lam P, Murrell GAC. (2009) A new method to measure contact pressure and strength in rotator cuff repair: which repair is best? 76th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, February 25-28, 2009. Poster.
Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GAC. (2009) Heat shock protein and apoptosis in supraspinatus tendinopathy. 76th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, February 25-28, 2009. Poster.
Baldwick C, Briggs L. Murrell GAC. (2009) The sonographic appearance of the rotator cuff after arthroscopic repair. 76th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, February 25-28, 2009. Poster.
79 Murrell GAC, Wu X, Baldwick C. (2009) “Undersurface Arthroscopic Rotator Cuff Repair” 76th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, February 25-28, 2009. DVD-Video 43.
Andres B, Lam P, Murrell GAC. (2009) Tension, abduction and surgical technique effect footprint compression following rotator cuff repair in an ovinemodel. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, Nevada, February 22-25th, 2009, paper.
Peters K, McCallum S, Murrell G (2009) Outcomes of arthroscopic repair of partial thickness versus full thickness rotator cuff tears. 2009 Conference of Science and Medicine in Sport 13-17th October 2009 Brisbane Paper 30.
Wu X, Baldwick C, Briggs L, Murrell G. (2009) Arthroscopic under surface rotator cuff repair. 2009 Australian Conference of Science and Medicine in Sport 13-17th October 2009. Paper 31
Peters K, Lam P, Murrell G (2009) Repair of partial thickness rotator cuff tears: A biomechanical analysis of footprint pressure and strength in an ovine model. 2009 Australian Conference of Science and Medicine in Sport Brisbane 13th-17th October 2009. Paper 35
Murrell G. (2009) Examination of the shoulder, What’s new, what works and what does not. 2009 Australian Conference Science and Medicine in Sport 13-17th October 2009 Brisbane. Workshop 84
McCallum, S Paoloni J, Murrell G. (2009) Five year prospective comparison of topical glyceryl trinitrate treatment of chronic lateral epicondylosis at the elbow. 2009 Australian Conference of Science and Medicine in Sport 13-17th October 2009 Brisbane Paper 162
Xu Y, Bonar F, Murrell G. (2009) Expression of neuronal markers PGP9.5 and GAP43 in tendinopathic rotator cuff tendon. 2009 Australian Conference of Science and Medicine in Sport Brisbane 13th- 17th October 2009. Paper 163
Wei A, Brisby H, Molloy T, Chung S, Murrell G, Diwan A. (2009) The effect of running exercise on intervertebral disc extracellular matrix production in a rat model. 2009 Australian Conference of Science and Medicine in Sport Brisbane 13th-17th October 2009. Paper 371
Murrell G, Briggs L. (2009) Ultrasound evaluation of the shoulder. 2009 Australian Conference of Science and Medicine in Sport Brisbane 13th-17th October 2009. Workshop 431
Lam P,Peters K,Murrell GAC. (2009) Partial thickness rotator cuff repairs: a biomechanical analysis of footprint contact pressure and pull-out strength in an ovine model. The St George and Sutherland Hospital Medical Research Symposium 2009. New Investigator Basic Science Finalist.
McCallum SDA,Paoloni J,Murrell GAC. (2009) Five year prospective comparison study of topical glyceryl trinitrate treatment of chronic lateral epicondylosis at the elbow. The St George and Sutherland Hospital Medical Research Symposium 2009. Independent Learning Project Finalist.
80 UNSW DEPARTMENT OF SURGERY, LIVER & PERITONECTOMY UNIT
1. Departmental Staff
Head of Department David Lawson Morris MB ChB FRCS MD PhD FRACS (Professor of Surgery, UNSW)
Senior Medical Staff Frank Chu MBBS FRACS Seema Bagia MBBS FRACS
Research Staff Principal Scientist Mohammad Pourgholami (M. Pharm; PhD, MIPS)
Senior Scientist Javed Akhter (PhD)
Research Assistants Samina Badar (MSC)
Research students Ahmed Mekkway Anahid Ehteda Krishna Pillai Parvin Ataie Farnaz Bahrami
Nursing staff Peritonectomy CNCs Vanessa Saunders Helen Kennedy
Database Manager/Equipment Technician Jing Zhao
81 2. Research Grants#
National, peer reviewed Source: AUS Industries Principal investigators: Prof David Morris Project title: Clinical Trial of Albendazole for Malignant Ascites Total awarded; years funded: $800K; 2007-2009
Other funding: UNSW Foundation /David Morris Liver Cancer Research Fund Source: Donations Total: $35,815
Peter Laurence Kirby Fund for Research into Pseudomyxoma peritonei Source: Donation Total: $500,000
3. Research Projects in Progress
Topic: Evaluation of tertracyclines as potential agents for the treatment of peritoneal mesothelioma Principal investigators: Mohammad Pourgholami, David Morris
Topic: Gender disparity in peritoneal mesothelioma Principal investigators: David Morris, Krishna Pillai, Mohammad Pourgholami
Topic: Evaluation of minocycline as an antiangiogenic, antitumor agent Principal investigators: Mohammad Pourgholami, David Morris
Topic: Minocycline for the treatment of ovarian cancer and malignant ascites formation Principal investigators: Mohammad Pourgholami, Parvin Ataie, David Morris
Topic: Pharmacological evaluation of minocycline: unveiling the therapeutic potentials Principal investigators: Mohammad Pourgholami, Farnaz Bahrami, David Morris
Topic: Systemic delivery of albendazole for the treatment of cancer Principal investigators: David Morris, Anahid Ehteda, Mohammad Pourgholami
82 4. Original Peer-Reviewed Publications
Adie S, Yip C, Chu F, Morris DL. Resection of liver metastases from colorectal cancer: does preoperative chemotherapy affect the accuracy of PET in preoperative planning? ANZ J Surg, 2009. 79(5): p. 358-361.
Cao C, Yan TD, Liauw W, Morris DL. Comparison of optimally resected hepatectomy and peritonectomy patients with colorectal cancer metastasis. J Surg Oncol (JSO), 2009. 100(7): p. 529-533.
Chu SWL, Badar S, Morris DL, Pourgholami MH. Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole. Anticancer Res, 2009. 29(10): p. 3791-3796.
Chua TC, Akhter J, Yao P, Morris DL. In vivo model of pseudomyxoma peritonei for novel candidate drug discovery. Anticancer Res, 2009. 29(10): p. 4051-4055.
Chua TC, Yan TD, Morris DL. Outcomes of cytoreductive surgey and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma: The Australian Experience. J Surg Oncol (JSO), 2009. 99(2): p. 109-113.
Chua TC, Yan TD, Ng KM, Zhao J, Morris DL. Significance of lymph node metastasis in patients with colorectal cancer peritoneal carcinomatosis. World J Surg (WJS), 2009. 33(7): p. 1488-1494.
Chua TC, Yan TD, Smigielski ME, Zhu KJ, Ng KM, Zhao J, Morris DL. Long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years experience from a single institution. Ann Surg Oncol (ASO), 2009. 16(7): p. 1903-1911.
Chua TC, Yao P, Akhter J, Young L, Bao S, Samaraweera U, Yan TD, Morris DL. Differential expression of Ki-67 and sex steroid hormone receptors between genders in peritoneal mesothelioma. Pathology & Oncology Res, 2009. 15(4): p. 671-678.
Ding JH, Chua TC, Glenn D, Morris DL. Feasibility of ablation as an alternative to surgical metastasectomy in patients with unresectable sarcoma pulmonary metastases. (Case Report - Thoracic oncologic). Interactive CardioVascular and Thoracic Surgery (ICVTS), 2009. 9(6): p. 1051-1053.
83 Haghighi KS, Glenn D, Gruenberger T, Morris DL. Extending the limits for curative liver resections by portal vein embolisation. International Surg, 2009. 94(1): p. 43-47.
Huo ASY, Morris DL, King J, Glenn D. Use of percutaneous radiofrequency ablation in pulmonary metastases from renal cell carcinoma. Ann Surg Oncol (ASO), 2009. 16(11): p. 3169-3175
Koh JL, Yan TD, Glenn D, Morris DL. Evaluation of preoperative computed tomography in estimating peritoneal cancer index in colorectal peritoneal carcinomatosis. Ann Surg Oncol (ASO), 2009. 16(2): p. 327-333.
Ng KM, Yan TD, Black D, Chu F, Morris DL. Prognostic determinants for survival after resection/ablation of a large hepatocellular carcinoma. HPB, 2009. 11(4): p. 311-320.
Pourgholami MH, Cai ZY, Wang L, Badar S, Links M, Morris DL. Inhibition of cell proliferation, vascular endothelial growth factor and tumor growth by albendazole. Cancer Investigation, 2009. 27(2): p. 171-177.
Saxena A, Yan TD, Chua TC, Fransi S, Almohaimeed K, Ahmed S, Morris DL. Risk factors for massive blood transfusion in cytoreductive surgery: A multivariate analysis of 243 procedures. Ann Surg Oncol (ASO), 2009. 16(8): p. 2195-2203.
Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, Gilly FN, Levine EA, Shen P, Mohamed F, Moran BJ, Morris DL, Chua TC, Piso P, Sugarbaker PH. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: Multi-institutional experience. J Clin Oncol (JCO), 2009. 27(36): p. 6237-6242.
Zhu JC, Yan TD, Glenn D, Morris DL. Radiofrequency ablation of lung tumors: Feasibility and safety. Ann Thorac Surg, 2009. 87(4): p. 1023-1029.
Zhu KJ, Morris DL. Primary peritonectomy / HIPEC for disseminated peritoneal adenomucinosis achieves much lower recurrence rates and better survival than secondary procedures. Surgeon, 2009. 7(6): p. 345-350.
84 5. Other published material
Mekkawy A, Morris DL, Pourgholami MH. Urokinase plasminogen activator system as a potential target for cancer therapy. Future Oncology, 2009. 5(9): p. 1487-1499.
Chua TC, Robertson G, Liauw W, Farrell R, Yan TD, Morris DL. Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery in ovarian cancer peritoneal carcinomatosis: Systematic review of current results. J Cancer Res Clin Oncol (JCRCO), 2009. 135(12): p. 1637-1645.
Chua TC, Pelz JO, Kerscher A, Morris DL, Esquivel J. Critical analysis of 33 patients with peritoneal carcinomatosis secondary to colorectal and appendiceal signet ring cell carcinoma. Ann Surg Oncol (ASO), 2009. 16(10): p. 2765-2770.
Chua TC, Yan TD, Zhao J, Morris DL. Peritoneal carcinomatosis and liver metastases from colorectal cancer treated with cytoreductive surgery perioperative intraperitoneal chemotherapy and liver resection. Eur J Surg Oncol (EJSO), 2009. 35(12): p. 1299-1305.
Chua TC, Koh J, Yan TD, Liauw W, Morris DL. Cytoreductive surgey and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. J Surg Oncol (JSO), 2009. 100(2): p. 139-143.
Chua TC, Yan TD, Saxena A, Morris DL. Should the treatment of peritoneal carcinomatosis by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy still be regarded as a highly morbid procedure? A systematic review of morbidity and mortality. Ann Surg, 2009. 249(6): p. 900-907.
Cao CQ, Yan TD, Black D, Morris DL. A systematic review and meta-analysis of cytoreductive surgery with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin. Ann Surg Oncol (ASO), 2009. 16(8): p. 2152-2165.
Chua TC, Yan TD, Morris DL. Surgical biology for the clinician: Peritoneal mesothelioma: Current understanding and management. Can J Surg, 2009. 52(1): p. 59-64.
Chua TC, Yan TD, Yap ZL, Horton MD, Fermanis GG, Morris DL. Thoracic cytoreductive surgery and intraoperative hyperthermic intrathoracic chemotherapy for pseudomyxoma peritonei. J Surg Oncol (JSO), 2009. 99(5): p. 292-295.
85 7. Presentations at Scientific Meetings/Conferences
International
1st International Conference & Workshop on Up to Date Obstetrics & Gynecology at King Fahad Medical City, Riyadh 13th -15th April 2009 Peritonectomy role in advanced/recurrent ovarian cancer.
National Symposium on Update of Oncology & Lymphoma at King Fahad Specialist Hospital Buraidah, Al Qassim & Prince Faisal Bin Bandar Cancer Centre, 8th April 2009 Cytoreductive surgery
The 5th Scientific Conference for Saudi General Sugery Society, 19-21 October 2009, King Fahad Medical Research Centre, King Abdulaziz University Jeddah Peritonectomy for colorectal cancer, pseudomyxoma peritonei peritoneal mesothelioma and ovarian cancer.
Annual Cancer Symposium Society of Surgical Oncology, 5th March 2009 – Phoenix Arizona, USA Poster Presentation: Chua TC, Yao P, Akhter J, Young L, Bao S, Samaraweera U, Yan TD, Morris DL. Differential expression of Ki-67, estrogen receptor, and progesterone receptor between genders in peritoneal mesothelioma: An immunohistochemistry study that provides a plausible explanation for the better prognosis in females?
ASCO Annual Meeting Abstracts, May 29-June 2, 2009 – Orlando, FL Poster Presentation: Chua TC, Robertson G, Farrell R, Liauw W, Yan TD, Morris DL. Systematic review of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian peritoneal carcinomatosis: A more efficacious way of delivering intraperitoneal chemotherapy. J Clin Oncol. 27(15s), 2009 (Suppl; abstract no: 5524).
International Liver Cancer Association Third Annual Conference (ILCA) at the HCC Milan Conference, September 4-6, 2009, Milan, Italy Oral Presentation: Chua TC, Liauw W, Saxena A, Chu F, Glenn D, Chai A, Morris DL. Systematic review of randomized and nonrandomized trials on the clinical efficacy and safety of neoadjuvant transarterial chemoembolization (TACE) for resectable hepatocelluar carcinoma. Abstract No: O-016. Accepted for publication in Liver International.
86 National
Integrated Cancer Centres Symposium 9th &10th December 2009 – Hilton on the Park, Melbourne. Improving the cancer patient’s journey in Australia
The Dynamics of an award winning integrated cancer centre: Panel Discussion: • What facilities and services make an integrated cancer centre ‘award winning’?
Perfecting cancer care facility performance: • Surgical Oncology – what is needed and why? • Effect of hospital/surgeon volume • Operative mortality • 5 yr survival • Oesophagectomy • Colorectal cancer • Pancreatic cancer • Liver resection • Peritonectomy
Royal Australasian College of Surgeons Annual Scientific Congress, May 6, 2009 – Brisbane, Australia Oral Presentation: • Saxena A, Morris DL. Risk factors for massive blood transfusion after cytoreductive surgery and perioperative intraperitoneal chemotherapy.
Poster Presentation: • Saxena A, Morris DL. Preoperative and operative risk factors for complications after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei.
Medical Legal Conference, Amora Hotel, Jamison St, Sydney 24 July 2009 Oral Presentation: • Maunic M, Morris DL. Colon cancer.
87 DEPARTMENT OF VASCULAR SURGERY
1. Departmental Staff
Head of Department K C Hanel MB BS FRACS DDU
Visiting Medical Officers E Farmer MB BS FRACS DDU L D Lemech MB BS FRACS DDU G McMullin MB BS FRACS FRCS DDU J Iliopoulos MB BS (Hons) FRACS PhD
Vascular Trainee M Krishnaswamy N Andrawis FRACS
2. Research Projects in Progress
Prospective evaluation of a model to predict outcomes following Endovascular Aortic Aneurysm Repair. R Fitridge (QEH, Adelaide), L D Lemech Managing trauma in the austere environment: a project for special operations command of the Australian army. J Iliopoulos, W R Walsh (S&ORL NSW)
Adhesions in lumbar spine surgery. J Iliopoulos, W R Walsh (S&ORL NSW)
Training of Defense Force staff in simple tissue handling procedures in a sheep carcass model. J Iliopoulos, W R Walsh (S&ORL NSW)
Evaluation of bio-resorbable materials for reduction of pelvic soft tissue attachments in a porcine model. J Iliopoulos, W R Walsh (S&ORL NSW)
88 PERI-OPERATIVE CARE DEPARTMENT OF ANAESTHETICS
1. Departmental Staff
Head of Department Richard Morris MBBS FANZCA
Senior Medical Staff Staff specialists Maggie Bailey BMBS FANZCA Lecturer Conjoint UNSW Chimene Bhar MBBS FRCA Neil Bradburn MBBS FANZCA Lecturer Conjoint UNSW Peter Cox MBBS FANZCA Marie Dreux BMBS FANZCA Lecturer Conjoint UNSW Anthony Lewis PhD MB BCh FRCA FANZCA Liz Mackson MBBS FANZCA Andrew Mcdonald MBBS FANZCA Peter Nay MBBS FRCA FANZCA Pauline Paton MBBS FANZCA Sharon Tivey MBBS FANZCA Lecturer Conjoint UNSW Anica Vasic MBBS FANZCA
Visiting Medical Officers Andrew Armstrong MBBS FANZCA Lecturer Conjoint UNSW Philip Black BMBS FANZCA Peter Brennan MBBS FANZCA Michael Cooper BMBS FANZCA Daniel Cox BMBS FANZCA Vincent DaSilva MBBS FANZCA Cyrus De Souza MBBS FANZCA Tamara Eichel MBBS FANZCA Robert Fabian MBBS FANZCA Salwan Fransi MBBS FANZCA Lecturer Conjoint UNSW David Goodie MBBS FANZCA Rajiv Gupta MBBS FANZCA Andrew Guy MBBS FANZCA Simon Harper MBBS FANZCA Drew Heffernan MBBS FANZCA Michael Henderson MBBS FANZCA Robert Higgs MBBS FANZCA Cameron Hunt MBBS FANZCA Gerhard Labuschagne MB ChB MMed(Anest) FCA(SA) FANZCA
89 Harold Lam MBBS FANZCA Mike Lambros MBBS FANZCA Ben Ma MBBS FANZCA Bobby Manasiev MBBS FANZCA Joanne Momsen MBBS FANZCA Jodi Murphy MBBS FANZCA Manu Narayanaswamy MBBS FANZCA Neeraj Pal MBBS FANZCA Pamela Salerno MBBS FANZCA Mark Stewart MBBS FANZCA Sue-Ann Wan MBBS FANZCA David Ware MBBS FANZCA
Fellows Roger Bloomer MB ChB FRCA Matthew Coady MBBS Mark Higney MB ChB FRCA Maggie Jedlicka MBBS Ting Ting Liu MBBS
Registrars Colleen Bruce MBBS Grace Chieng MBBS Alex Fang MBBS Martin Graves MBBS Robert Heavener MBBS Maryam Hezar MBBS Suyen Ho MBBS Timothy Holliday MBBS Rosa Hou MBBS Brendan Irvine MBBS Michael Kerr MBBS Gisele Mouret MBBS Neil Vanza MBBS Brett Wells MBBS Gordon Wong MBBS
90 2. Research Projects in Progress
Topic: Audit of Central Venous Catheter placement Principal investigators: Anthony Lewis and Alex Fang Status Completed and presented at Departmental Meeting in September 2010
3. Original Peer-Reviewed Publications
Rathore KS, Cooper MG, Manganas C. Limited excision of a right atrial lipoma. Heart, Lung & Circulation 2009; 18: 365-371.
4. Other published material MG Cooper – Contributor to Kilham H, Alexander S, Wood N, Isaacs D, eds. Paediatric Manual – The Children’s Hospital at Westmead Handbook. 2nd ed, McGraw-Hill 2009.
5. Presentations at Scientific Meetings/Conferences International Medical Development Programs – Australian & New Zealand College of Anaesthetists. Cooper MG. 2nd International Medical Aid Symposium, Royal Australasian College of Surgeons, Melbourne, 21st August, 2009. Airway management for infants with severe micrognathia having mandibular distraction osteogenesis. Cooper MG, Brooker GE, Innes DF. Society for Paediatric Anaesthesia in New Zealand and Australia. Oct 29 – Nov 1, 2009. Canberra.
91 DEPARTMENT OF TRAUMA
1. Departmental Staff
Head of Department Dr Mary Langcake (Trauma)
Senior Nursing Staff A/Prof Kate Curtis (Trauma) RN, PhD Trauma clinical nurse consultant Conjoint A/Prof UNSW, Senior Research Fellow (The George Institute for International Health), Senior Research Fellow (IRMC UNSW), Clinical A/Prof (Sydney Nursing School)
Junior Medical Staff Dr Caesar Okello MBBS (Trauma fellow) Dr Mark Macaranas MBBS (Surgical trainee) Dr Allan Kwok MBBS (Surgical trainee)
Nursing Research Staff Sarah Kourouche RN, Ms Nurs Emergency (trauma clinical nurse specialist) Alana Clements RN, Cert Nurs Crit Care/Emergency (trauma clinical nurse specialist)
Research Staff Taneal Wiseman RN, PhD candidate (Trauma clinical nurse consultant)
2. Research Grants
Other funding
St George Medical Research Foundation Establishment Grant. (2009 $10,000) Cost of Trauma in NSW. Curtis K, Myburgh J, Langcake M.
College of Nursing Consortium Fund Research Grant. (2009 $30,000) Depression, Anxiety and Stress in major trauma patients. Curtis K, Foster K
Post Doctoral Fellowship in Trauma (2009-2011 $133,000) Cost of Trauma in NSW and trauma program of research. Curtis K
92 3. Research Projects in Progress
Cost of trauma Curtis, Black & Myburgh
The accuracy of AN-DRG cost weight in describing the trauma patient LOS and direct costs. Curtis, Black, Lam & Dickson
Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a ‘panscan’ protocol Asha, Smart, Compangnoni, Taylor & Curtis
Trauma Patient Outcomes in South East Sydney Illawarra. Curtis K, Mitchell R, Chong S, Langcake M
Long-term trauma outcomes data collection: NSW pilot study Mitchell R, Watson W, Curtis K, Harris I et al.
Sex differences in trauma Dr Murray Fisher & Clinical A/Prof Kate Curtis
The relationship between mental health and major trauma patients of an Australian Trauma Centre: A mixed methods explanatory study. Wiseman, Curtis & Foster.
What makes an emergency nurse? An investigation into personality profiles and retention Kennedy, Curtis, Waters & Hyde.
The scribe nurse in major trauma: Does level of experience improve quality of documentation and leadership? Curtis, Clements, Horvat & Langcake.
Coagulation studies and alterations correlating to ABG results Higney, Wong, Curtis & Morris
Evaluation of a structured assessment model for emergency nurses (ENAF) Curtis, Murphy, Hardy, Buckley & Lewis
Rear Seat Safety Project Brown, Hatfield & Curtis
Incidence, management and outcome of Hypothermia in Trauma Patients: The experience of a Level 1 trauma centre Macaranas, Curtis, Langcake, Okello
93 Trauma registry data: how representative is it for road traffic injury surveillance? Mitchell, Curtis & Williamson
Subdural Haemmorrhage in older persons: a comparison of outcomes between those on anticoagulants at the time of injury and those not. Asha, Keady, Curtis & Kohan
Does the use of patient controlled analgesia in blunt thoracic trauma reduce complications and improve outcome? Asha, Curtis, Kwok, Langcake
4. Original Peer-Reviewed Publications
Ursic C, Curtis K, Zou Y, Black D Improved trauma patient outcomes after implementation of a dedicated trauma admitting service. Injury. 2009; 40:99-103
Curtis K., Dickson C, Black D & Nau T The Cost and Compensability of Trauma patients. Aust Health Rev; 2009; 33(1): 84-92
Curtis K, Murphy M, Hoy S & Lewis M The Emergency Nursing Assessment Process - A structured framework. Australasian Emergency Nursing Journal. 2009; 12(4): 130-6
5. Presentations at Scientific Meetings/Conferences
International invited
Langcake M March 2009 (New Zealand). Surgery in a Theatre of Operations - An Afghan Experience. Combined Australasian Trauma Society and Trauma Association of Canada Annual Scientific Meeting
94 National Invited
Curtis K. October 7-10 2009 (Gold Coast) The great debate – the future of Emergency Nursing. 7th International Conference for Emergency Nursing. CENA.
Curtis K October 30th 2009 (Sydney) Critical Aspects of trauma nursing care. ANZICS/ACCCN. Asia Pacific Critical Care Congress. Langcake M May 1st (Wollongong) Trauma On The Coast, NSW Institute of Trauma and Injury Management
Conference papers
TY Pang, KT Thai, T Rankin, K Curtis, E, Schilter, AS McIntosh (2009) Risk of head and neck injury in pedal and motor cycle crashes in relation to helmet use. Road Safety Research, Education and Policing Conference, 10 - 13 November 2009, Sydney Convention Centre Darling Harbour, Sydney, NSW, Australia
Curtis K, Olivier J, Rankin T, Cook A, Rana A & Nau T (2009) Evaluation of a tiered trauma system in an Australian Level 1 Trauma Centre. 7th International Conference for Emergency Nursing. CENA. October 7-10 2009, Gold Coast, Queensland
Curtis K The cost of trauma in NSW. Emerging Health Policy Research Annual Conference 18th August 2009, Darlington Centre, University of Sydney
Curtis K, Olivier J, Rankin T, Cook A, Rana A & Nau T (2009) Evaluation of a tiered trauma system in an Australian Level 1 Trauma Centre. Combined Australasian Trauma Society and Trauma Association of Canada Annual Scientific Meeting, Auckland Convention Centre, Auckland, New Zealand March 5-7 2009
Frydenberg E, Curtis K, Chong S, Poulos R & Nau T (2009) The profile, incidence and outcomes of head injuries in pedestrians. Combined Australasian Trauma Society and Trauma Association of Canada, Annual Scientific Meeting, Auckland Convention Centre, Auckland, New Zealand March 5-7 2009
Curtis K, Fraser M, Rankin T, Watson W & Nau T (2009) Injury risk among older persons – an injury prevention initiative (2009) Combined Australasian Trauma Society and Trauma Association of Canada Annual Scientific Meeting, Auckland Convention Centre, Auckland, New Zealand, March 5-7 2009
Rana A, Ling M, Curtis K & Nau T (2009) Non operative management of high grade splenic injury: review of factors leading to high spleen salvage rate in a level 1 trauma Centre. Combined Australasian Trauma Society and Trauma Association of Canada Annual Scientific Meeting, Auckland Convention Centre, Auckland, New Zealand, March 5-7 2009
95 6. Community Engagement
St George Hospital Trauma Service hosts 4 Early Management of Severe Trauma courses a year. The EMST course is a 2.5 day intensive course in the management of injury victims in the first 1–2 hours following injury. It is adapted from the Advanced Trauma Life Support (ATLS®) course of the American College of Surgeons. The emphasis is on developing life saving skills and a systematic clinical approach. It is designed for all doctors who are involved in the early treatment of serious injuries in urban or rural areas, whether or not sophisticated emergency facilities are available. On each course 4 nurse observers participate also.
Dr Langcake has also presented trauma topics to the Lions Club, the Lamrock Committee and the Medical Women’s Society of NSW.
Since 2004 St George Hospital Trauma and Allied Health services have joined together to offer local seniors (aged 50 years and older) a Safety Seminar providing tips on home safety, access to information, and community resources and products that will help them to prevent falls and injuries. This very successful free seminar is held at St George Leagues Club.
PAIN MANAGEMENT UNIT
Departmental Staff
Head of Department Anica VASIC MBBS FANZCA Conj Lecturer UNSW
Senior Medical Staff Staff specialists Peter COX MBBS FANZCA FFPMANZCA
Junior Medical Staff Anaesthesia Advanced trainee on rotation Dept Anaesthetics St George
96 CANCER CARE DEPARTMENT OF HAEMATOLOGY
1. Departmental Staff
Head of Department Prof Beng H Chong, MBBS, PhD(Syd), FRACP, FRCPA, FRCP (Professor of Medicine, UNSW)
Senior Consultant Staff Prof Szu-Hee Lee, MA (Cambridge), MBBChir (London), PhD, FRCPA, FRCPath, FRCPEdin, FRACP (Conjoint Professor of Medicine, UNSW) Dr Michael Harvey, MBBS, PhD, FRACP, FRCPA (Conjoint Senior Lecturer, UNSW) Dr Sundra Ramanathan, MBBS, FRACP, FRCPA Dr Shir-Jing Ho MBBS, FRACP, FRCPA. Fernando Roncolato MBBS, FRACP, FRCPA (locum) Dr Amanda Hugman, MBBS, FRACP, FRCPA
Junior Medical Staff Dr. Danny Hsu (Advanced Trainee, Clinical) Dr. Kyle King (Advanced Trainee, Clinical) Dr Nag Sungala (Advanced Trainee, Laboratory) Dr Matthew Ku (Advanced Trainee, Laboratory). Dr. Zianab Alarimi (Overseas fellow from Oman)
Research Staff Dr Xing-Mai Jiang, PhD (Post-doc scientist) Dr Jose Perdomo, BSc Hons, PhD (Post-doc scientist) Dr Simon Liang, PhD (Post-doc scientist) Dr. Jim Fang, PhD (Post-doc scientist) Zohra Ahmedi BSc Hons (Research assistant) Dr Arend Isaacs (Research Fellow) Dr Nicola Chapman BS Hons, PhD (Project manager, CTBR);
Research Students Daniel Carter (PhD student) Shen –Yee Liu (PhD student) Jia Yin New (PhD student) Steven Lasar (Hons student) Nathalie Tjen (Hons student)
97 Clinical Trial Unit Roslyn Ristuccia, MSc Trial Unit manager; Sarah Davidson RN, (trial nurse) Lorraine King RN (TSH); (trial nurse) Margaret Loizou BSc (study coordinator) Karina Chui RN (trial nurse) Elena Simon BSc (study coordinator) Kareen Fierro (trial assistant)
2. Research Grants
National, peer reviewed
Source: NHMRC. $11,945,128.00; 2007-2011 Principal investigators: Berndt MC, Chesterman C, Chong BH, Hogg P, Khachigian L, Parish C, Stocker R. Project title: Vascular Biology
Other funding
Covidien, $20,000.00. Year: 2009 Chong, Beng H; Chapman N; Project title: A study of VTE prophylaxis in patients with chronic heart failure and chronic respiratory diseases in the community.
Boehringer Ingelheim. $50000; 2009-2010 Chong, Beng H; Chapman N; Project title: Research to increase knowledge on thrombosis related disorders in surgical and medical patients.
St George and Sutherland Medical Research Foundation Grant to Dr Simon Liang $20,000
98 3. Research Projects in Progress
Generation of a humanized scFv and its evaluation for treatment of heparin-induced thrombocytopenia and thrombosis. Chong BH, Perdomo J, Jiang X-M.
Characterization of nuclear import and transcription regulation of NFE2. Chong BH, Perdomo J, Ee-ling Fock, Feng Yan.
In vivo animal model of investigation of drug-induced and primary immune thrombocytopenia Chong BH, Simon Liang;
Characterization of nuclear import, SUMOylation and transcription regulation of FOG2, cardiac transcription factor Chong BH, Perdomo J.
Understanding Hospital Physicians Perspectives and Attitudes towards the implementation of Venous Thromboembosis Prophylaxis. Nicola Chapman, Marissa Lassere, Margaret Fry, Beng H Chong.
Investigation of bleeding risk factors in medical patients – multicentre study. Décousus H, Tapson V, Bergmann J-F, Chong BH, Froehlich J, Kakkar A
Differentiation and migration of Sca-1+/CD31- cardiac side population cells in a murine myocardial ischemic model. Chong BH, Liang SX.
IFI-16, a novel gene that mediates molecular regulation of megakaryocyte differentiation. Chong BH, Perdomo J, Lacey Johnson.
Molecular mechanism of heparin-induced thrombocytopenia Chong BH, Perdomo J,X_M Jiang.
Characterization of the heamatopoietic oncogene, GATA-1. Chong B, Feng Yan, Perdomo J.
Validation that clinical use of best practice guidelines for venous thrombo-embolism prevention leads to improvement in health outcomes. Chong BH, Nicola Chapman, Marissa Lassere.
A pattern of care cohort study of Venous Thromboembolism (VTE) treatment for compliance with international guidelines Chong BH, Nicola Chapman
99 Heparin-induced thrombocytopenia (HIT): Characterization of the pathogenic and non- pathogenic antibodies, and studies to improve laboratory diagnosis and treatment Chong BH, Isaacs A
Vancomycin-induced thrombocytopenia in hospitalized patients Chong BH, Chapman NH
4. Original Peer - Reviewed Publications
Rodeghiero, F., Stasi, R., Gernsheimer, T., Michel, MC., Provan, D., Arnold, D., Bussel, J., Cines, D., Chong, BH. et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: Report from an international working group, Blood, 2009; 113: 2386 - 2393, 2009.
Chong, BH. Primary immune thrombocytopenia: Understanding pathogenesis is the key to better treatments, Journal of Thrombosis and Haemostasis, 2009; 7: 319 - 321.
Chong BH, Isaacs, A. Heparin-induced Thrombocytopenia: What clinicians need to know. Thromb Haemostat. 2009; 101: 279-283.
Shantsila E, Lip GYH, Chong BH. Heparin-induced thrombocytopenia: A contemporary clinical approach to diagnosis and management. Chest. 2009; 135 :1651-1664.
Chapman NH, Brighton T, Harris NF, Caplan GA, Braithwaite J, Chong BH. Venous thromboembolism: Management in general practice. Australian Family Physician. 2009; 38: 36-40.
5. Other Published Material
Fletcher J, Baker R, MacLellan D, Chong BH, Fisher C, Gallus A, Gibbs H, Hannan T, Matthews G, Salam H, Stacey M and van Rij A. Prevention of venous thromboembolism: Best Practice Guidelines for Australia and New Zealand. Health Education and Management International (ISBN 0 9578909 0 7), Sydney 4th Edition 2009
100 6. Presentations at Scientific Meetings/Conferences
Kuter DJ, Rummel MJ, Boccia R, Macik G, Pabinger DJ, Selleslag D, Rodeghiero F, Chong BH, et al. Comparison of splenectomy and treatment failure incidences in nonsplenectomized patients with immune thrombocytopenia(ITP) treated with Romiplostim or medical standard of care: 1 year treatment and 6 month safety follow-up. American Society of Haematology, New Orleans, December, 2009.
Nathalie Tjen, Nicola Chapman, Zohra Ahmadi, Beng H Chong. Vancomycin-induced thrombocytopenia in hospitalised patients. Proceedings of the Annual Meeting of Australian New Zealand Society of Haematology, Adelaide, October, 18th-21st, 2009.
Steven Lazar, Nicola Chapman, Marissa Lassere, Margaret Fry, Beng H Chong. Understanding Hospital Physicians Perspectives and Attitudes towards the implementation of Venous Thrombosis Prophylaxis. Proceedings of the Annual Meeting of Australian New Zealand Society of Haematology, Adelaide, October, 18th-21st, 2009
7. Community Engagement
Centre for Thrombotic and Bleeding Disorder Research website: Venous thromboembolism (VTE) support group providing advice to community on prevention and treatment of VTE
101 DEPARTMENT OF MEDICAL ONCOLOGY
1. Departmental Staff
Head of Department Dr Kiran Phadke FRACP FRCPA
Staff Specialists A/Prof Winston Liauw FRACP A/Prof Matthew Links FRACP Dr Paul de Souza FRACP Dr Jodi Lynch FRACP Dr David Thomas FRACP Dr Chee Lee FRACP Dr Patricia Bastick FRACP
2. Research Grants
National, peer-reviewed
Prostate Cancer Foundation of Australia. $450,000 (2010-2012) A translational and pharmacokinetic study of a novel, orally-active targeted treatment for hormone refractory prostate cancer. de Souza PL, Scott K, Graham G, young P, Liauw W, Russell P.
Cancer Australia and Prostate Cancer Foundation of Australia, NHMRC $584,000 (2009-10) Preclinical evaluation of novel prostate-targetted nanoparticles for imaging primary and metastatic prostate cancer. Russell PJ, Bucci J, de Souza P, Khatri A
Other Grants
St George and Sutherland Medical Research Foundation Seed Grant $20,000 A quantitative assay for novel compounds that show promise as oral treatments for advanced prostate cancer. Scott KF, Graham G, Liauw W, de Souza P.
UNSW Gold Star Award $40,000 Clinical trial of a novel, orally-active, secreted phospholipase A2 inhibitor for the treatment of prostate cancer
102 3. Research Projects in Progress
Assessment of DCE-MRI for brain tumours Xiang Jie Lay, Foster S, You D, P de Souza
Quality of life, hope, and spirituality in cancer patients with varying prognoses Man J, Hogan S, Shin S, de Souza P
Synergism in renal cancer cell lines using angiogenesis inhibitors. Man Kong Chin, Shaojuan Li, de Souza P
A phase 1 study of RAD001 (everolimus) in combination with fluvastatin and zoledronic acid in patients with solid tumours. Lemech C, Pene C, Fontela A, de Souza P
Modulation of Akt phosphorylation by isoprenylation inhibitors. Shaojuan Li, P de Souza (PI)
4. Original Peer-Reviewed Publications de Souza PL, Russell PJ, Kearsley JH. Role of PI3K and Akt biology in prostate cancer. Current Cancer Drug Targets. 2009; 9(2):163-175
McPherson RAC, Galettis PT, de Souza PL. Enhancement of the activity of phenoxodiol, a synthetic isoflav-3-ene, by cisplatin in prostate cancer cells. British Journal of Cancer. 2009; 100(4):649-55.
Crombie C, Burns WI, Karapetis C, Lowenthal RM, Kirsten F, Davidson JA, Abell F, Reece WHH, Iglesias J, de Souza P.A Randomized Phase II Trial of Gemcitabine and Either Day 1 or Day 8 Carboplatin for Advanced Non-Small Cell Lung Cancer. Asia Pacific Journal of Clinical Oncology, Published online 24 Feb 2009; 5: 24–31
Dutcher JP, de Souza P, McDermott D, Figlin RA, Berkenblit A, Thiele A, Krygowski M, Strahs A, Feingold J, Hudes G. Effect of Temsirolimus versus Interferon-α on Outcome of Patients with Advanced Renal Cell Carcinoma of Different Tumor Histologies. Medical Oncology 2009;26(2):202-9. Epub 2009 Feb 20
Figlin RA, de Souza P, McDermott D, Dutcher JP, Berkenblit A, Thiele A, Krygowski M, Strahs A, Feingold J, Boni J, Hudes G. Analysis of PTEN and HIF-1α and Correlation with Efficacy in Patients with Advanced Renal Cell Carcinoma Treated with Temsirolimus Versus Interferon-α. Cancer 2009;115(16):3651-60
103 Chua TC, Robertson G, Liauw W, Farrell R, Yan TD, Morris DL. Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery in ovarian cancer peritoneal carcinomatosis: systematic review of current results. J Cancer Res Clin Oncol. 2009 Dec;135(12):1637-45.
Chua TC, Liauw W, Robertson G, Morris DL. Establishing evidence for change in ovarian cancer surgery--proposing clinical trials of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer peritoneal carcinomatosis. Gynecol Oncol. 2009 Oct;115(1):166-8; author reply 8-9.
Chua TC, Liauw W, Robertson G, Chia WK, Soo KC, Alobaid A, et al. Towards randomized trials of cytoreductive surgery using peritonectomy and hyperthermic intraperitoneal chemotherapy for ovarian cancer peritoneal carcinomatosis. Gynecol Oncol. 2009 Jul;114(1):137-9; author reply 9.
Chua TC, Liauw W, Morris DL. The St George Hospital Peritoneal Surface Malignancy Program - where are we now? ANZ J Surg. 2009 Jun;79(6):416-8.
Chua TC, Liauw W, Morris DL. New treatments and outcomes in peritoneal carcinomatosis. Med J Aust. 2009 Jul 6;191(1):3-4.
Chua TC, Koh JL, Yan TD, Liauw W, Morris DL. Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. J Surg Oncol. 2009 Aug 1;100(2):139-43.
Chua TC, Al-Mohaimeed K, Liauw W, Morris DL. Pseudomyxoma peritonei: a need to establish evidence-based standard of care--is this the right trial? Ann Surg Oncol. 2009 Oct;16(10):2675-7.
Cao CQ, Yan TD, Liauw W, Morris DL. Comparison of optimally resected hepatectomy and peritonectomy patients with colorectal cancer metastasis. J Surg Oncol. 2009 Dec 1;100(7):529-33.
104 5. Presentations at Scientific Meetings/Conferences
Pendergrass K, Hudes G, Radulovic S, Beck J, Dutcher J, Berkenblit A, Thiele A, Krygowski M, de Souza P. Characterization of Hyperglycemia, Hypercholesterolemia And Hyperlipidemia in Patients with Advanced Renal Cell Carcinoma Treated With Temsirolimus or Interferon-α. Poster presentation, ASCO GU meeting, Orlando, Feb 2009.
Yang S, Hudes G, deSouza P, Alemao E, Strahs A, Purvis J. Quality of Life in Patients With Advanced Renal Cell Carcinoma Treated With Temsirolimus or Interferon Alfa: Results of a Phase III Randomized Trial. Poster presentation, ESMO, Berlin, September 2009.
Webber K, Fontela A, Bonner N, Bell J, Bucci J, de Souza P, Lewis C, Hui R, Graham P, Links M. CRP predicts tolerance of treatment and overall survival with weekly carboplatin-paclitaxel and concomitant irradiation for locally advanced non-small cell lung cancer. Poster presentation, 13th World Conference on Lung Cancer, San Francisco, August 2009. de Souza P, Boyer M, Lowenthal R, Rosenthal M, Goldstein D, Toner G, Wong S, Davis I. Pazopanib in Renal Cell Carcinoma: Efficacy and Safety in Phase II and III Trials. Oral presentation, COSA, Gold Coast, November 2009
6. Community Engagement
1. Involvement with Prostate Cancer Institute for improvement of prostate cancer services at St. George Cancer Care Centre
2. Involvement with the community in extension of Sutherland Hospital’s Oncology Unit for additional psychology, allied health services and bereavement facilities, as well as education
105 DEPARTMENT OF RADIATION ONCOLOGY
1. Departmental Staff*
Head of Department Professor J H Kearsley MBBS (Hons Syd) FRACP FRANZCR PhD (Qld)
Senior Medical Staff (staff specialists) A/Professor Peter Graham MBBS, FRANZCR, Cert Bioethics, Grad Dip Medical Statistics Dr Joseph Bucci MBBS FRACP FRANZCR Dr Catherine Clark MBBS FRANZCR Dr Yaw Chin BSc (Med)FRANZCR
Junior Medical Staff Dr Nadine Beydoun Dr Megan Berry Dr Penny Magoulas Dr Annie Lee
Research Staff Peter Fink, Clinical Trials Unit Manager – Radiation Oncology Helen Cox –Clinical Research Co-ordinator Sima Don - Clinical Research Co-ordinator Manuela Glinski-Smith - Clinical Research Co-ordinator Kylie Melki - Clinical Research Co-ordinator Xiaolu Wang - Clinical Research Co-ordinator
Senior Research Staff Dr Yong Li PhD, MSc BM Dr Lois Browne BSc, PhD, GDip Med Stats, MMed Stats, AStat A/Prof Raymond Clarke PhD Prof Barry Allen Professor Anatoly Rosenfeld PhD
Research Assistants Z M Fang
Research Students - From Yong Li’s group Julia Beretov: PhD student Jingjing You: PhD student Jingli Hao: PhD student Weiwei Xiao: PhD student Dr Paul de Souza : PhD student
106 Nursing Research Staff Lydia Wong - Clinical Research Nurse
Administration Jane Hagin - Administration Officer Kareen Fierro - Clinical Trials Assistant Megan Ristuccia - Administrative Assistant
Radiation Therapy Research Staff Laurel Schmidt
Medical Physics Research Staff Brad Oborn Andrew Howie
2. Research Grants#
National, peer reviewed
Li Y. NHMRC Career Development Fellow (Level 2): Identification of novel biomarkers in urine to improve diagnosis and monitor progression in prostate cancer. $417,000 (2010-2014)
Li Y. Cancer Institute NSW Career Development Fellowship: Using proteomic approaches to identify novel biomarkers in tear and serum to improve diagnosis and monitor progression. $543,189 (2007- 2010).
Li Y, Willcox MD, Cozzi PJ, Russell PJ, Walsh BJ, Zhao Z. Australian Research Council (ARC)-linkage. Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. $100,000 (2007-2010).
Clinical Trials Network Supported Studies (NSW Cancer Council / NSW Cancer Institute) Breast STARS Pilot Randomised Controlled Trial Chief Investigator: P Graham Year support commenced: 2007
The Cancer Institute NSW Cancer Trials Network, Cancer Trials Nurses and Data Managers Grant CISES103 25 Jan 05 Investigators: P Graham, P de Souza, D Gorman, M Links 2005-2007 NSW Cancer Institute For $84,900 + $5000 first year, plus $84,900 renewable. 1.0 FTE Clinical Trials Nurse
107 NHMRC Project: ID573428 Rosenfeld A, Kron T, Conway M et al High spacial resolution dosimetry for radioactive plaques used for radiotherapy of eye lesions. 2009 $139,750; 2010 $119,750; 2011 $94,750.
Chief Investigators: A Prof B Chua, Prof S Fox, A Prof G Delaney AProf M McKay, Dr P Schofield, A Prof I Campbell Associate Investigators: Prof S Lakhani, Dr A Milner, A Prof P Graham Dr D Blakey, Dr J Harvey, A Prof D Christie, Dr E Millar. NHMRC Project Grant 454390 (2007-2011) Title: A randomized phase III study of radiation dose and fractionation schedules in nonlow risk ductal carcinoma in situ (DCIS) of the breast. Amount: $1,648,750
3. Research Projects in Progress
Trial Clinical Trials Trial Tumour Principal Recruitment Current Sponsor Start Date Nickname Conducted Registration Grouping Investigator End Date Status
A randomised trial investigating the effectiveness of different durations of maximal TROG androgen deprivation Urogenital - John Follow up NA TROG 26/08/1998 18/01/2002 96.01 prior to and during Prostate Kearsley only definitive radiation therapy for locally advanced carcinoma of the prostate. Tumour volume as an independent prognostic Respiratory TROG factor in patients with NCT00351598 - Lung TROG Peter Graham 25/05/2000 31/07/2007 Closed 99.05 non-small cell lung (NSCLC) cancer: A protocol for a prospective database. Pulmonary Fibrosis following breast conservation adjuvant Pulp radiotherapy: the STG - NA Breast Peter Graham 1/01/2003 Recruiting Fiction modifying effects of inhouse systemic therapies (chemotherapy and tamoxifen) A phase III study of Breast - Follow-up MA 20 regional RT in early breast NCT00005957 NCIC CTG Peter Graham 12/03/2004 2/02/2007 Breast only cancer (NCIC MA20). Randomised trial investigating the effect on survival and PSA control of different durations of adjuvant Urogenital - Follow-up RADAR NCT00193856 TROG Joseph Bucci 1/08/2004 16/08/2007 androgen deprivation in Prostate only association with definitive radiation treatment for localised carcinoma of the prostate (RADAR).
108 Trial Clinical Trials Trial Tumour Principal Recruitment Current Sponsor Start Date Nickname Conducted Registration Grouping Investigator End Date Status
STARS Pilot Breast Trial: A randomised comparison of Anatrazole commenced before and continues St George during radiotherapy fr Hospital Peter Follow up STARS NCT00126360 Breast 28/06/2005 15/09/2009 breast cancer versus Peter Graham only Anastrazole and Graham subsequent Anti- Oestrogen therapy delayed until after radiotherapy. A collaborative randomised phase III trial: The timing CCVic, of intervention with Urogenital - Joseph TOAD NCT00110162 RANZCR 1/03/2005 Recruiting androgen deprivation Prostate Bucci TROG & USA in prostate cancer patients with a rising PSA. Prospective Outcomes-analyses Urogenital - St George Joseph PopART for localised Prostate NA 1/06/2006 25/09/2008 Closed Prostate Hospital Bucci Adenocarcinoma after Radiotherapy Treatment A randomised phase III study of radiation TROG 07.01 doses and fractionation DCIS Breast Peter Mac/ Peter NCT00470236 26/06/2007 Recruiting DCIS schedules in non-low Cancer TROG Graham risk ductal carcinoma in situ (DCIS) of the breast. A phase III multi-centre randomised trial comparing adjuvant radiotherapy (rt) with Joseph RAVES early salvage rt in NCT00860652 Prostate TROG 29/04/09 Recruiting Bucci patients with positive margins or extraprostatic disease following radical prostatectomy. Whole Brain Radiotherapy following local treatment of WBRT ACTRN12607 Peter intracranial metastases Brain ANZMTG 01/07/10 Recruiting Melanoma 00512426 Graham of melanoma - A randomised phase III trial A randomised comparison of Anastrozole commenced before and continued during TROG 08.06 adjuvant radiotherapy Peter NCT00887380 Breast TROG 16/09/10 Recruiting STARS for breast cancer Graham versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. Testicular Patient-reported Cancer Outcome Monitoring Testicular Joseph NA PoCoG 26/10/10 Recruiting Validation in Testicular Cancer Cancer Bucci Study Patients Testicular Understanding the Cancer long-term psychosocial Testicular Joseph NA PoCoG 26/10/10 Recruiting Survivors sequelae of surviving Cancer Bucci Study testicular cancer
109 4. Original Peer-Reviewed Publications
De Souza P, Russell P, & Kearsley J. The role of the AKT pathway in prostate cancer. Current Cancer Drug Targets 9 (2), 2009, 163-175.
Miller, EKA, Graham PH, O’Toole, S A, McNeil CM, Browne L, Morey AL, Eggleton S, Beretov J, Theocharous C, Capp A, Nasser E, Kearsley JH, Delaney G, Papadatos G, Fox C, Sutherlan RL. Prediction of local recurrence, distant metastases and death following breast-conserving therapy in early-stage invasive breast cancer using a five biomarker panel. Journal of Clinical Oncology 27 (28) 2009: 4701- 4708.
Fang ZM, Tse R, Marjoniemi VM, Kozlov S, Lavin MF, Chen H, Kearsley JH, Graham PH, Clarke RA. Radioresistant malignant myoepithelioma of the breast with high level of ATM protein: Radiation Oncology – Case Report in Journal of Medical Imaging and Radiation Oncology 53 (2) 2009:234- 239.
Li Y, Song E, Rizvi SMA, Power CA, Beretov J, Raja C, Cozzi PJ, Bruchertseifer F, Apostolidis C, Allen BJ Russell PJ. Inhibition of micrometastatic prostate cancer cell spread in animal models by 213Bi- labeled multiple targeted α radioimmunoconjugates. Clin Cancer Res 2009;15:865-875.
Wang L, Madigan MC, Chen HM, Liu FH, Patterson KI, Beretov J, O’Brien P, Li Y. Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients. Gynecol Oncol 2009;114:265-272.
Chen H, Hao JL, Wang L, Li Y. Coexpression of invasive markers (uPA, CD44) and multiple drug resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression. Br J Cancer 2009;101:432-440
P H Graham, J L Graham. Use of deodorants during adjuvant breast radiotherapy: a survey of compliance with standard advice, impact on patients and a literature review on safety. J Med Imaging Radiat Oncol 2009;53(6):569-73.
Yilmaz H, Millar EKA, Theocharous C, Graham P. Metachronous bilateral primary low-grade mucosa-associated lymphoid tissue (MALT) non-hodgkin’s lymphoma of the breast. Asia Pacific J Clin Oncol 2009; 5: 154-158
Graham PH, Martin RM, Browne LH . Communicating breast cancer treatment complication risks: when words are likely to fail. Asia Pacific J Clin Oncol 2009; 5(3): 193-199
Graham PH. Supraclavicular radiotherapy and lymphedema. Int J Radiat Oncol Biol Phys 2009;74 (5) :1627
Spry N, Bydder S, Harvey J, Borg M, Ngan S, Miller J, Graham P, Zissiadis Y, Kneebone A, Ebert M. Accrediting radiation technique in a multicentre trial of chemoradiation for pancreatic cancer. J Med Imaging Radiat Oncol 2009; 52(6):598-604.
110 Anokhin I, Zinets O, Rosenfeld A, Lerch M, Yudelev M, Perevertaylo V, Reinhard, M and Petasecca M . Studies of the characteristics of silicon neutron sensors. IEEE Trans Nucl Sci, NS 56, N 4 , 2290-2293 , 2009
Wroe, A., Schulte, R., Fazzi, A., Pola, A., Agosteo, S., Rosenfeld, A. RBE estimation of proton radiation fields using a Δe-E telescope. Med Phys, 36 (10), 4486-94, 2009.
Oborn, B.M, Metcalfe, PE, Butson, MJ, Rosenfeld, AB. High resolution entry and exit Monte Carlo dose calculations from a linear accelerator 6 MV beam under the influence of transverse magnetic fields. Med Phys, 36 (8), 3549-3559, 2009.
Hardcastle N, Metcalfe PE, Rosenfeld AB, Tome WA. Endo-rectal balloon cavity dosimetry in a phantom: Performance under IMRT and helical tomotherapy beams. Radiotherapy & Oncology 92, (1) 48-56, 2009.
Dowdell S., Clasie B., Wroe A., Guatelli S., Metcalfe P., Schulte R., Rosenfeld A. The suitability of tissue substitutes for neutron dosimetry in proton therapy. Med Phys, 36 (12), 5412-5419, 2009
Livingstone J, Horowitz YS, Oster L, Datz H, Lerch M, Rosenfeld A, Horowitz A. Experimental investigation of the 100 keV X-ray dose response of the high-temperature thermoluminescence in LiF:Mg,Ti (TLD-100): Theoretical interpretation using the unified interaction model. Rad Prot Dosi published on Nov 2009.
Penfold SN, Rosenfeld AB, Schulte RW, Schubert K. A more accurate reconstruction system matrix for quantitative proton computed tomography. Med Phys 36 (10), 4511-4518, 2009
Lai NS, Lim WH, Ziebell AL, Reinhard MI, Rosenfeld AB, Dzurak AS. Development and Fabrication of Cylindrical Silicon-on-Insulator Microdosimeter Arrays, IEEE Trans on Nucl. Sci. ,NS-56 , 1637-1641, 2009
Siegbahn EA, Brauer-Krisch E, Bravin A, Nettelbeck H, Lerch MLF, Rosenfeld AB. MOSFET dosimetry with high spatial resolution in intense synchrotron-generated x-ray microbeams”, Med Phys, 36(4), 1128-1137, 2009
Lim WH, , Ziebell AL, Cornelius I, Reinhard MI, Prokopovich DA, Dzurak AS, Rosenfeld AB. Cylindrical Silicon-on-Insulator Microdosimeter: Design , Fabrication and TCAD modeling. IEEE Trans on Nucl. Sci, NS-56, issue 2, 424-428, 2009
Nettelbeck H, Takacs GJ, Lerch M.LF, Rosenfeld AB. Microbeam radiation therapy: a Monte Carlo study of the influence of the source, multislit collimator, and beam divergence on microbeams. Med Phys. 36(2):447-456, 2009
Zhen-Yu Qi, Xiao-Wu Deng , Shao-Min Huang, Li Zhang, Zhi-Chun He, X Allen Li Ian Kwan, Michael Lerch , Dean Cutajar, Peter Metcalfe, Anatoly Rosenfeld “In vivo verification of surface and superficial dose for head and neck treatments using intensity-modulated techniques” , Med. Phys 36(1), 59 – 70, 2009.
111 I. S. Kwan, D. Wilkinson, D. Cutajar, M. Lerch, , Y.Wong, J.Bucci, V.Perevertaylo A. B. Rosenfeld . The effect of rectal heterogeneity on wall dose in High Dose-Rate brachytherapy”, Med. Phys 36(1), 224 – 232,2009.
Wroe A, Clasie B, Kooy H, Flanz J, Schulte R, Rosenfeld, A. Out-Of-Field Dose Equivalents Delivered by Passively Scattered Therapeutic Proton Beams for Clinically Relevant Field Configurations”, Int. Journal Rad. Oncol. Phys. and Biol. (IJOROPB), Volume 73, Issue 1, 306-313, Jan 2009
Williams M, Metcalfe P, Bailey M, Rozenfeld A, Forstner D, Everitt C, Kron T, Cornes D and Foo K. A dosimetric Inter-Comparison of Australian Radiotherapy IMRT Systems (ICARIS), Journal of Medical Imaging and Radiation Oncology 53(S1) A63, 2009.
5. Other published material
Rosenfeld A “Semiconductor detectors in radiation medicine: Radiotherapy and related applications”, in Radiation Detectors for Medical Applications, p.111-148 Tavernier, S.; Gektin, A.; Grinyov, B.; Moses, W.W. (Eds.) ISBN-10: 1-4020-5092-5
Rosenfeld A “Semiconductor Radiation Detectors in Modern Radiation Therapy”, in a book Microdosimetric Response of Physical and Biological Systems. To Low-and High-LET Radiations: Theory and Application for Dosimetry”, Edited by Y.Horowitz, Elsevier, ISBN-13:978-0-444-51643-5, 367- 410, 2006.
Penfold S.N., Schulte R.W., Censor Y, Bashkirov V, McAllister S, Schubert K.E., Rosenfeld A.B., “Block Iterative and string-averaging projection algorithms in proton computed tomography image reconstruction”, In: Biomedical Mathematics: Promising Directions in Imaging, Therapy Planning and Inverse Problems, Y. Censor, M. Jiang and G. Wang (Eds), Medical Physics Publishing, Madison, WI, accepted.
6. Presentations at Scientific Meetings/Conferences
International
Wang L, Chen H, Hao JL, Li Y (2009). Co-expression of invasive markers (uPA, CD44) and multiple drug resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression. 5th International Conference on Tumor Microenvironment: Progression, Therapy and Prevention. Versailles, Oct 20-24, 2009
Hao JL, Madigan MC, Chen HM, Cozzi PJ, Delprado WJ, Li Y (2009). Is there a relationship between the expression of CD147 (EMMPRIN), CD44, multidrug resistance (MDR) and monocarboxylate
112 (MCT) transporters, and prostate cancer (CaP) progression? 5th International Conference on Tumor Microenvironment: Progression, Therapy and Prevention. Versailles, Oct 20-24, 2009
Wang L, Chen H, Liu F, Madigan MC, Hao JL, Power C, Patterson KI, Beretov J, Pourgholami MH, O’Brien PM, Perkins AC, Kearsley J, Li Y (2009). Preclinical studies using monoclonal ant-MUC1 and docetaxel: A novel strategy for targeting advanced epithelial ovarian cancer. 20th Asia Pacific Cancer Conference. Tsukuba, Japan 12-14 Nov, 2009.
Hao JL, Madigan MC, Chen H, Cozzi PJ, Beretov J, Khatri A, Delprado WJ, Russell PJ, Kearsley J, Li Y (2009). The co-operative roles of CD147 and CD44 in prostate cancer chemoresistance and metastasis. 20th Asia Pacific Cancer Conference. Tsukuba, Japan 12-14 Nov, 2009.
You J, Fitzgerald A, Cozzi PJ, Zhao Z, Graham P, Russell PJ, Walsh BJ, Willcox M, Li Y (2009) Identification of potential biomarkers for prostate cancer in tears and serum using proteomic approaches. 20th Asia Pacific Cancer Conference. Tsukuba, Japan 12-14 Nov, 2009. AMG 655 abstract describing the 295 study accepted for “publication only” by ASCO. 2006029: ASCO 2009
Kate Webber, Antoinette Fontela, Nina Bonner, Janet Bell, Joseph Bucci, Paul De Souza, Craig Lewis, Rina Hui, Peter Graham, Matthew Links. CRP predicts tolerance of treatment and overall survival with weekly carboplatin-paclitaxel and concomitant irradiation for locally advanced non-small cell lung cancer. ASCO 2009.
You J, Fitzgerald A, Cozzi PJ, Zhao Z, Graham P, Russell PJ, Walsh BJ, Wilcox M, Li Y. Identification of potential biomarkers for prostate cancer in tears and serum using proteomic approaches.
Ball D, Fisher R, Burmeister B, Poulsen M, Graham P, Penniment M, Vinod S, Krawitz H, Joseph D, Wheeler G, McClure B. Lung tumour volume and survival in patients with non-small cell lung cancer (NSCLC) treated by definitive radiotherapy (RT): TROG 9905. J Med Im Radiat Oncol 53 Suppl 1:A108
Ewan KA Millar, Peter H Graham, Sandra A O’Toole, Catriona M McNeil, Lois Browne, Adrienne L Morey, Sarah Eggleton, Julia Beretov, Constantine Theocharous, Ann Capp, Elias Nasser, John H Kearsley, Geoff Delaney, George Papadatos, Christopher Fox, Robert L Sutherland. Prediction of local recurrence, distant metastases and death following breast-conserving therapy in early-stage invasive breast cancer using a five biomarker panel.
Graham PH, Graham JL Proscription of deodorants during adjuvant breast radiotherapy: a survey of compliance, patient impact and evidence of safety. World Lung Cancer Conference, San Francisco 31 July 2009
D Ball, R Fisher, B Burmeister, M Poulsen, P Graham, M Penniment, S Vinod, H Krawitz, D Joseph, G Wheeler, B McClure The complex relationship of lung tumor volume to survival in patients with non- small cell lung cancer (NSCLC) treated by definitive radiotherapy (RT): (Trans Tasman Radiation Oncology Group Study 9905). J Thoracic Oncol 4(9) Suppl 1:S335
113 Penfold SN, Schulte RW, Censor Y, Bashkirov V, Rosenfeld AB. Characteristics of Proton CT images Reconstructed with Filtered Backprojection and Iterative Projection Algorithms, 2009 IEEE Nucl. Sci. Symp. Conf. Rec. 4176−4180 HT5-2, 2009.
Penfold SN, Schulte RW, Bashkirov V, Rosenfeld AB. Fast and accurate proton computed tomography image reconstruction for applications in proton therapy, Medical Physics and Biomedical Engineering World Congress 2009 IFMBE Proceedings 25/1, O. Dössel and Schlegel (Eds.), 213−216 ff.
Bashkirov V, Schulte R, Coutrakon G, Erdelyi B, Wong K, Sadrozinski H, Penfold S, Rosenfeld A, McAllister S, Schubert K. Development of proton computed tomography for applications in proton therapy. AIP Conf. Proceedings: 20th CAARI Conf 460−463, 2009.
Wong K, Erdelyi B, Schulte R, Bashkirov V, Coutrakon G, Sadrozinski H, Penfold S, Rosenfeld A. The effect of tissue inhomogeneities on the accuracy of proton path reconstruction for proton computed tomography. , AIP Conf. Proceedings: 20th CAARI Conf. 476−480, 2009.
National
RANZCR/AIR/FRO/ACPSEM ASM Brisbane Oct 2009 D Ball, R Fisher, B Burmeister, M Poulsen, P Graham, M Penniment, S Vinod, H Krawitz, D Joseph, G Wheeler, B McClure. Lung tumour volume and survival in patients with non-small cell lung cancer (NSCLC) treated by definitive radiotherapy (RT): TROG 99.05.
Webber K, Fontela A, Bonner N, Bell J, Bucci J, De Souza P, Lewis C, Hui R, Graham P Links M. CRP predicts tolerance of treatment and overall survival with weekly carboplatin-paclitaxel and concomitant irradiation for locally advanced non-small cell lung cancer MOGA 30th ASM ACT August 2009( Asia Pacific J Clin Oncol 2009; 5(S1):A54)
Significant interactions that could be usefully publicised. Li Y (2009)
The 5th International Conference on Tumour Microenvironment: Progression, Therapy and Prevention. Versailles, Oct 20-24, 2009 (2009)
The 20th Asia Pacific Cancer Conference. Tsukuba, Japan 12-14 Nov, 2009 (the chair of the section). (2009)
In May 2009, the Clinical Trials Unit, which includes the Department of Radiation Oncology as one of its departments, was one of 5 New South Wales trial units nominated by the Cancer Institute at the 2009 Premier’s Awards for Outstanding Cancer Research - for “Innovation in Clinical Trials”. The event was held on Thursday evening 21 May at the Exhibition Centre at Darling Harbour.
114 DEPARTMENT OF PALLIATIVE CARE SERVICES (St George Hospital & Calvary Health Care)
1. Departmental Staff
Head of Department Dr Jan Maree Davis B Med (Hons) FRACP FAChPM
Senior Medical Staff Dr Frank Brennan MB BS FRACP FAChPM Dr Amy Waters MB BS FRACP FAChPM Dr Judith Lacey FRACGP FAChPM
Research Staff
Associate Professor Elizabeth Lobb, PhD. MAppSci. B.AdEd. Associate Professor of Palliative Care (Allied Health); Adjunct Associate Professor School of Medicine, University of Notre Dame; Adjunct Associate Professor of Psycho-oncology, WA Centre for Cancer & Palliative Care, Curtin University of Technology, Perth WA; Adjunct Associate Professor of Psych-oncology, School of Nursing, Midwifery and Post-Graduate Medicine, Edith Cowan University, Honorary Associate, NH&MRC Clinical Trials Centre, University of Sydney.
Dr Christine Sanderson, BA, BMBS, MPH, FRACP. Staff Specialist in Palliative Medicine, Calvary Health Care Sydney; Research Fellow, CareSearch, Flinders University of South Australia; PACCSC (Palliative Care Clinical Studies Collaborative) investigator.
Nursing Research Staff Ms. Annmarie Hosie, RN, Cert P.C., Masters Palliative Care
2. Research Grants
National peer reviewed
NHMRC $122,111 Group education program for family caregivers of people receiving palliative care in an inpatients setting Hudson P, Oldham L, Lobb EA, Auret K.
115 Other Funding
Cancer Institute NSW – Research Infrastructure Grant - $528,507 NSW Palliative Care Research Collaborative Group (IMPACCT) Agar M, Davidson P, Clayton J, Good P, Lovell M, Sanderson C, Lobb EA.
St George Hospital $93,000 A study to explore factors which contribute to coping with uncertainty in patients diagnosed with incurable cancer. KearsleyJ, Lacey J, Lobb EA
Enhancement Fund UNSW $45,000 Attitudes and information needs of women newly diagnosed with breast cancer regarding treatment-focussed genetic testing. Meiser B, Mitchell G, Lobb EA, Tucker K, Saunders C, Barlow-Stewert K, Gleeson M.
Strategic Research Partnership Grants – Cancer Council NSW $213, 532 Psychological impact of hereditary cancer and the development and evaluation of effective patient education and decision support strategies. Meiser B, Lobb EA, Tucker K, Andrews L, Kirk J, Friedlander M, Butlow P, et al
3. Research Projects in Progress
A double-blind placebo controlled study of subcutaneous ketamine in the management of cancer pain (PACCSC multisite study) Sanderson C , Hardy J, Plummer J, Rowett D, Eckermann S, Currow D, Shelby-James T, Agar M, Spruyt O, Fazekas B, Good P, Stevenson J, Eng D, Glare P.
Randomised control trial of oral risperidone, oral haloperidol, and oral placebo with rescue subcutaneous midazolam in the management of delirium in palliative care inpatients (PACCSC multisite study) Site Investigator: Sanderson C Lead Investigator: Agar M; CIs: Draper B, Caplan G, Hill M, Shelby- James T, Rowett D, Currow D, Lawlor P, Sanderson C, Plummer J.
Observation Study of Nursing Clinical Handover in Palliative Care and Rehabilitation Wards at Calvary Health Care Sydney Lobb, EA, Stranix, T. Moore, H., Harris, C., Richardson, B., Thornton, S, Barrett, M., Evans, M.
A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer Kearsley, J., Lacey, J., Lobb, EA, Liauw, W., Thomas, D.
116 Family Conferences in Palliative Care Tobin, B., Ingham, J., Lobb, EA
Prevalence and predictors of long term psychological morbidity in bereaved cancer care-givers Butow, P., Prince, M., Kristjanson, LJ., Lobb, EA.
Supportive Care Needs of Carers of Malignant Brain Tumour Patients Price, M., Lobb, EA, Hovey, E.
4. Original Peer-Reviewed Publications
Zilliacus E, Meiser B, Lobb, EA, Barlow-Stewart, K., Tucker, K. A Balancing Act – Tele-health Cancer Genetics and Practitioner’s Experiences of a Triadic Consultation. Journal of Genetic Counseling. 2009; 18(6): 598-605.
Lobb EA, Gaff C., Meiser B., Butow P, Osseiran-Moisson R, Hallowell N. A comparison of male attendees and non-attendees at a familial cancer clinic. Genetics in Medicine 2009; 11(11): 806-811.
Lobb EA, Joske D, Butow P, Kristjanson LJ, Cannell P, Cull G, Augusten B, Hollingsworth S. When the safety net of treatment has been removed: Patient’s unmet needs at the completion of treatment for haematological malignancies. Patient Education and Counseling. 2009; 77(1):103-108.
Lobb EA, Gaff C, Meiser B, Butow P, Osseiran-Moisson R, Hallowell N. Attendance of men at the familial cancer clinic: what they value from the consultation. Genetics in Medicine 2009; 11(6):434-440
5. Presentations at Scientific Meetings/Conferences
Zilliacus E, Meiser B, Lobb EA, Barlow-Stewart B, Kirk J, Spiegelman AD, Warwick L, Tucker K. Telehealth Cancer Genetic Counselling: an evaluation of videoconferencing to outreach areas KConFab Familial Cancer Conference, Gold Coast, August, 2009.
McConigley R, Halkett G, Lobb EA, Nowak, A. Exploring the experiences and needs of Family Caregivers of people with High Grade Glioma. Clinical Oncological Society of Australasia, Gold Coast, November, 2009.
Vojkovic S, Smith J, Oldham, Lobb EA, Dwyer V, Brown J, Hussain M, Fournie, C. Development and evaluation of a support and debrief training program specifically developed for palliative care staff. 10th Australian Palliative Care Conference, 8th Asia Pacific Hospice Conference, Perth, September, 2009.
117 CLINICAL TRIALS UNIT, DIVISION OF CANCER SERVICES
1. Departmental Staff
Head of Unit Associate Professor Peter Graham, MBBS, FRANZCR, Cert Bioethics, Grad Dip Medical Statistics Clinical Trials Unit Director
Staff Specialists Medical staff specialist Oncology Dr Joseph Bucci, MBBS, FRACP, FRANZCR Associate Professor Peter Graham, MBBS, FRANZCR, Cert Bioethics, Grad Dip Medical Statistics Professor John Kearsley, MB BS (Hons Syd) FRACP FRANZCR PhD (Qld) Dr Paul de Souza, MB BS, FRACP, MS Associate Professor Winston Liauw, MBBS MMedSci FRACP Associate Professor Matthew Links, MBBS (Syd) FRACP PhD Dr Jodi Lynch, BSc. MBBS (Hons) FRACP Dr David Thomas, MBBS FRACP
Haematology Professor Beng Chong, MBBS, PhD, FRCP, FRACP, FRCPA Dr Michael Harvey, MB BS, PhD, FRACP, FRCPA Dr Sundra Ramanathan, MBBS, FRACP, FRCPA Dr Shir-Jing Ho, MBBS, FRACP, FRCPA Dr Fernando Roncolato, B Med FRACP FRCPA
Research Staff Oncology Peter Fink, Clinical Trials Unit Manager – Medical Oncology and Radiation Oncology Helen Cox –Clinical Research Co-ordinator Sima Don - Clinical Research Co-ordinator Antoinette Fontela - Clinical Research Co-ordinator Manuela Glinski-Smith - Clinical Research Co-ordinator Mary Margaret Gozar - Clinical Research Co-ordinator Tracy Liaw - Clinical Research Co-ordinator Kylie Melki - Clinical Research Co-ordinator Stephen Millard –Clinical Research Nurse Linda O’Malley - Clinical Research Nurse Shu Pan - Clinical Research Co-ordinator Penny Taylor - Clinical Research Nurse Lisa Wang - Clinical Research Co-ordinator Xiaolu Wang - Clinical Research Co-ordinator
118 Lydia Wong - Clinical Research Nurse Haematology Roslyn Ristuccia, Clinical Trials Unit Manager – Clinical Haematology Karina Chui - Research Nurse Sarah Davidson - Research Nurse Lorraine King - Clinical Research Co-ordinator Margaret Loizou - Clinical Research Co-ordinator Elena Mendoza-Simon - Clinical Research Co-ordinator Patricia Peters - Research Nurse
Administration Jane Hagin - Administration Officer Kareen Fierro - Clinical Trials Assistant Megan Ristuccia - Administrative Assistant
2. Research Grants
National Peer-reviewed.
Cancer Council NSW $418,140 over 3 years Response of metastatic melanoma to bi-fold targeted alpha therapy of tumour capillary pericytes and melanoma cells. Allen B, Graham P, Hamilton A, Thompson J
NHMRC Project Grant 454390 (2007-2011) A randomized phase III study of radiation dose and fractionation schedules in non-low risk ductal carcinoma in situ (DCIS) of the breast. CIs: Chua B, Fox S, Delaney G, McKay M, Schofield P, Campbell I. Lakhani S, Milner A, Graham P, Blakey D, Harvey J, Christie D, Millar E.
Other Grants
Cancer Institute NSW – translational program grant $3,747,812 over 5 years Anti-Mitochondrial Cancer Drugs Hogg P, Ward R, Dawes I, Lock R, de Souza P.
NHMRC Research Program Grant- $1,575,750 over 5 years Using clinical and economic evidence to inform local decision making in cancer care Ward R, Haas M, Viney R, van Gool K, Pearson S, Links M, Hall J, Stewart J, Board N.
CTN-01-010 Awarded to Dr Matthew Links 1st Round 2002 0.5 FTE Study Nurse Original value of grant: $32,000 Funding renewed 2003-2009
119 CTN-03-030 Awarded to Dr Tim Brighton- transferred to Assoc Professor Peter Graham 3rd Round 2005 3rd Round CTN Centre Funding for $33,000 for the employment of 0.5 FTE institutional cancer support person.
Clinical Trials Network Supported Studies (NSW Cancer Council / NSW Cancer Institute) Breast STARS Pilot Randomised Controlled Trial Chief Investigator: P Graham Year support commenced: 2007
NSW Cancer Trials Network, Cancer Trials Nurses and Data Managers Grant $174,800 FTE Clinical Trials Nurse Investigators: M Harvey, M Links 1.0 FTE Clinical Trials/Research Nurse Haematology
Cancer Australia and Prostate Cancer Foundation of Australia $584,000 (1/7/08-30/6/2010) Russell PJ, Thierry B, Walsh BJ, Bucci J, de Souza P, Khatri A “Preclinical evaluation of novel prostate-targeted nanoparticles for imaging primary and metastatic prostate cancer: This aims to develop antibody-targeted nanoparticles for increasing imaging sensitivity in prostate cancer”
NHMRC Using clinical and economic evidence to inform local decision making in cancer care Investigators: R Ward, M Haas, R Viney, K van Gool, S Pearson, M Links, J Hall, B Stewart, N Board
St George Medical Research Foundation Seed Grant. Scott KF, Graham G, Liauw W, de Souza P. A quantitative assay for novel compounds that show promise as oral treatments for advanced prostate cancer. 2009,
120 3. Research Projects in Progress
Principal Recruitment Current Clinical Trials Conducted Sponsor Start Date Investigator End Date Status
Tamoxifen for 5 years vs. Toremifene for 5 years with or without chemotherapy as adjuvant therapy for post/ Follow up IBCSG de Souza 1/01/1996 1/01/1997 perimenopausal, node positive, hormone receptor positive only breast cancer patients. AC x 4 followed by CMF x 3 with or without a International chemotherapy-free interval, +/- Tamoxifen for Follow up breast cancer de Souza 19/12/1996 4/08/1999 premenopausal patients with node positive breast cancer only study group who are not suitable for endocrine therapy alone. Adjuvant Therapy for Postmenopausal Patients with Operable Breast Cancer who have Estrogen Receptor or IBCSG/ Follow up Progesteron Receptor Positive Tumors Tamoxifen vs. Letrozole de Souza 1/03/1998 1/09/2006 Novartis only vs. Tamoxifen followed by Letrozole vs. Letrozole followed by Tamoxifen. Phase III randomised, multi-centre, international trial to determine the relation between dose and clinical activity Follow-up of STI—571 in patients with unresectable or metastatic AGITG Links 1/08/2001 1/02/2002 only malignant gastrointestinal stromal tumors expressing the c—kit receptor tyrosine ki Randomized phase III trial comparing docetaxel in combination with doxorubicin and cyclophosphamide Aventis (fmrly Follow-up (TAC) versus doxorubicin and cyclophosphamide followed Breast Cancer Links 1/10/2001 1/10/2002 only by docetaxel (AC->T) as adjuvant treatment of operable International) breast cancer HER2neu negative patients with Randomized phase III trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC->T) with Breast Cancer Follow up doxorubicin and cyclophosphamide followed by docetaxel Links 1/10/2001 1/12/2004 International only and trastuzumab (AC->TH) and with docetaxel, platinum salt and trastuzumab (TCH) in the adjuvan Bristol Myers Squibb/ CARBO/TAX: Wkly Carboplatin + Taxol and Concomitant RT Follow-up St. George Links 1/10/2003 31/12/2006 for locally advanced NSCLC: Predictors of Rx Tolerance. only Hospital Matthew Links A phase III trial evaluating the role of ovarian function suppression and the role of exemestane as adjuvant ANZBCTG Lynch 31/05/2005 Recruiting therapies for premenopausal women with endocrine responsive breast cancer. A randomised phase II/III study design to evaluate the Follow up role of Mitomycin C, Avastin and Xeloda in patients with AGITG Liauw 1/04/2006 29/06/2007 only metastatic colorectal cancer. An intergroup phase III trial to evaluate the activity of Docetaxel, given either sequentially or in combination Follow up with Doxorubicin, followed by CMF, in comparison ANZBCTG de Souza 2/02/1999 1/06/2001 only to Doxorubicin alone or in combination with Cyclophosphamide, followed by CMF, in the adjuvan Phase II, multi-center, two-stage study utilising a randomised Active discontinuation design to evaluate the safety and efficacy GlaxoSmith treatment de Souza 14/03/2006 18/09/2006 of GW786034 in adult subjects with locally recurrent or Kline (& Follow metastatic clear-cell Renal Cell Carcinoma (RCC). Up) Phase ll trial pf Patupilone plus prednisone versus Docetaxel Follow up plus prednisone in patients with metastatic hormone Novartis de Souza 20/09/2006 01/10/09 only refractory prostate cancer Active A randomized, double-blind, muliti-centre, placebo- Glaxco-Smith treatment controlled study of Adjuvant Lapatanib in women with Lynch 19/09/2006 19/09/08 and Klein (& Follow early stage breast ErbB2 overexpressing breast cancer. Up) A phase 1b/2 study of AMG655 in combination with Follow up Paclitaxel and Carboplatin for the first line treatment of AMGEN de Souza 20/07/2007 17/10/2008 only Advanced Non Small Cell Lung Cancer
121 Principal Recruitment Current Clinical Trials Conducted Sponsor Start Date Investigator End Date Status
CRAD001C2325: A randomised, double blind, placebo controlled, multi centre phase III study in patients with Novartis Morris 31/07/2007 30/05/2008 Closed advanced carcinoid tumour receiving Sandostatin LAR® and RAD001 10mg/d or Sandostatin LAR® and placebo. A randomised comparative study of FOLFOX 6m plus SIR- Spheres versus FOLFOX6m alone as first line treatment in Follow up SIRTEX Winston Liauw 20/09/2007 1/12/2008 patients with non-resectable liver metastases from primary only Colorectal Carcinoma
The effectiveness of mindfulness group in reducing distress St George Thomas 5/12/2007 31/12/09 Closed in radiation therapy patients Hospital
A Phase 1 study of RAD001 (everolimus) in combination with fluvastin and zoledronic acid in patients with solid Novartis de Souza 18/06/2008 Recruiting tumours A Randomized Trial of Temsirolimus and Sorafenib as Second-Line Therapy in Patients With Advanced Renal Cell Wyeth de Souza 19/02/2008 Recruiting Carcinoma Who Have Failed First-Line Sunitinib Therapy A Randomised, Double-blind, Multicentre Phase III Study Active to Compare the Efficacy of AZD2171 in Combination with AstraZeneca treatment 5-fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX), to the Liauw 1/04/2008 13/12/2008 /quintile (& Follow Efficacy of Bevacizumab in Combination with FOLFOX in Up) Patients with Previously Untr A phase III randomized study of brivanib alaninate (bms-582664) in combination with cetuximab (erbitux®) versus placebo in combination with cetuximab NHMRC Liauw 1/04/2008 Recruiting (erbitux®) in patients previously treated with combination chemotherapy for metastatic colorectal carcino A Phase 1/11A Multiple Ascending dose study of BMS- 777607 in subjects with advanced or metastatic solid BMS de Souza 1/04/2008 12/12/2008 Closed tumours. Study VEG108844, a Study of Pazopanib versus Sunitinib in the Treatment of Subjects with Locally Advanced and/or GSK de Souza 5/12/2008 Recruiting Metastatic Renal Cell Carcinoma A phase II Biomarker Identification Trial for Erlotinib (Tarceva®) in Patient with advanced Pancreatic Roche Liauw 12/12/2008 Recruiting Carcinoma A phase I, open- label, cohort study of multiple doses of Cavataktm (coxsackievirus a21) given intravenously to Viralytics Winston Liauw 01/10/09 Recruiting stage iv solid tumour cancer patients bearing icam-1 with or without daf expressing tumours A Prospective, Randomised, Double-Blind, Placebo- Controlled Phase III Study of Modafinil to Improve Fatigue Sanofi-aventis Paul de Souza 02/11/09 Recruiting and Quality of Life in Patients Treated with Docetaxel-Based Chemotherapy for Metastatic Breast or Prostate Cancer. St. George A randomised comparison of breast conservation with or Follow-up Hospital Peter Graham 1/09/1996 26/06/2007 without lumpectomy radiotherapy boost only Peter Graham A randomised trial investigating the effectiveness of different durations of maximal androgen deprivation prior to and Follow up TROG John Kearsley 26/08/1998 18/01/2002 during definitive radiation therapy for locally advanced only carcinoma of the prostate. Tumour volume as an independent prognostic factor in patients with non-small cell lung cancer: A protocol for a TROG Peter Graham 25/05/2000 31/07/2007 Closed prospective database. Pulmonary Fibrosis following breast conservation adjuvant radiotherapy: the modifying effects of systemic therapies STG - inhouse Peter Graham 1/01/2003 Recruiting (chemotherapy and tamoxifen) A phase III study of regional RT in early breast cancer (NCIC Follow-up NCIC CTG Peter Graham 12/03/2004 2/02/2007 MA20). only Randomised trial investigating the effect on survival and PSA control of different durations of adjuvant androgen Follow-up TROG Joseph Bucci 1/08/2004 16/08/2007 deprivation in association with definitive radiation treatment only for localised carcinoma of the prostate (RADAR).
122 Principal Recruitment Current Clinical Trials Conducted Sponsor Start Date Investigator End Date Status
STARS Pilot Breast Trial: A randomised comparison of Anatrazole commenced before and continues during St George Follow up radiotherapy fr breast cancer versus Anastrazole and Hospital Peter Graham 28/06/2005 15/09/2009 only subsequent Anti-Oestrogen therapy delayed until after Peter Graham radiotherapy. A collaborative randomised phase III trial: The timing of CCVic, RANZCR intervention with androgen deprivation in prostate cancer , Joseph Bucci 1/03/2005 Recruiting patients with a rising PSA. TROG & USA Prospective Outcomes-analyses for localised Prostate St George Joseph Bucci 1/06/2006 25/09/2008 Closed Adenocarcinoma after Radiotherapy Treatment Hospital A randomised phase III study of radiation doses and Peter Mac/ fractionation schedules in non-low risk ductal carcinoma in Peter Graham 26/06/2007 Recruiting TROG situ (DCIS) of the breast. A phase III multi-centre randomised trial comparing adjuvant radiotherapy (rt) with early salvage rt in patients TROG Joseph Bucci 29/04/09 Recruiting with positive margins or extraprostatic disease following radical prostatectomy. Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma - A randomised ANZMTG Peter Graham 01/07/10 Recruiting phase III trial A randomised comparison of Anastrozole commenced before and continued during adjuvant radiotherapy for TROG Peter Graham 16/09/10 Recruiting breast cancer versus anastrozole and subsequent anti- oestrogen therapy delayed until after radiotherapy. Patient-reported Outcome Monitoring in Testicular Cancer PoCoG Joseph Bucci 26/10/10 Recruiting Patients Understanding the long-term psychosocial sequelae of PoCoG Joseph Bucci 26/10/10 Recruiting surviving testicular cancer Aspirin to prevent recurrent venous thromboembolism. A multi-centre, randomised, double-blind, placebo-controlled Open for clinical trial examining the efficacy and safety of low-dose NHMRC Beng Chong 05-May-03 Recruitment aspirin after initial oral anticoagulation to prevent recurrent venous thromboe TRA105325. An extension study of Eltrombopag olamine Open for (SB-497115-GR) in adults, with idiopathic thrombocytopenic GSK Beng Chong 01-Jan-07 Recruitment purpura (ITP), previously enrolled in a eltrombopag study Oral direct factor Xa inhibitor Rivaroxaban in patients with Open for acute symptomatic deep-vein thrombosis or pulmonary Bayer Beng Chong 01-May-07 Recruitment embolism. Oral direct factor Xa inhibitor Rivaroxaban in patients with Bayer - Open for acute symptomatic deep-vein thrombosis or pulmonary Beng Chong 25-Jun-07 Covance Recruitment embolism. Long term eltrombopag observational study- A long term observational ocular safety follow-up study on adults Open for who have received study medication (SB-497115-GR/ GlaxoSmithKline Beng Chong 05-Jul-07 Recruitment eltrombopag olamine or placebo) in a Phase II or phase III clinical study evaluating eltrombopag. PRTX-100A-201, Phase I, An open-label, sequential, dose escalation, repeat-dose study of the safety, pharmacokinetics, pharmacodynamics and Protalex Beng Chong 04-Mar-08 28 Feb 2009 Abandoned immunogenicity of PRTX-100 in adult patients with chronic Idiopathic Thrombocytopenic Purpura (ITP) Magellan- Multicenter, randomized, parallel Group Efficacy and safety study for the prevention of venous Open for Bayer Beng Chong 01-May-08 thromboembolism in hospitalized medically ill patients Recruitment comparing rivaroxaban with enoxaparin An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of AMG 531 in Thrombocytopenic Open for Amgen Inc Beng Chong 28-Jul-08 Subjects with Immune (Idiopathic) Thrombocytopenic Recruitment Purpura (ITP) Pilot study into the safety and efficacy of Open for thromboprophylaxis and treatment of thromboembolism in In-house Shir-Jing Ho 02/11/2007 recruitment patients with haematological malignancies
123 Principal Recruitment Current Clinical Trials Conducted Sponsor Start Date Investigator End Date Status
A Multinational, Multicentre, Randomised, Double Blind Study comparing the Efficacy and Safety of AVE5026 with Open For enoxaparin for the Prevention of Venous Thromboembolism Sanofi Aventis Beng Chong 3/3/2009 Recruitment in Patients Undergoing Major Abdominal Surgery (SAVE_ABDO) A safety and efficacy trial evaluating the use of Apixaban BMS/Pfizer c/o Open for for the extended treatment of deep vein thrombosis and Beng Chong 30/3/2009 PPD Recruitment pulmonary embolism.
A Randomised, Double-Blind, Double-Dummy, Parallel Group Study to Compare YM150 bid and qd Doses and Open for Astellas Beng Chong 26/08/2009 Enoxaparin for Prevention of Venous Thromboembolism in Recruitment Subjects Undergoing Elective Hip Replacement Surgery
A Safety and Efficacy Trial Evaluating the Use of Apixaban in Open for the Treatment of Symptomatic Deep Vein Thrombosis and BMS/Pfizer Beng Chong 18/9/2009 Recruitment Pulmonary Embolism
4. Original Peer-Reviewed Publications de Souza PL, Russell PJ, Kearsley JH. Role of PI3K and Akt biology in prostate cancer. Current Cancer Drug Targets, 2009 March, 9(2):163-175
McPherson RAC, Galettis PT, de Souza PL. Enhancement of the activity of phenoxodiol, a synthetic isoflav-3-ene, by cisplatin in prostate cancer cells. British Journal of Cancer, 2009 Feb 24, 100(4):649- 55. Epub 2009 Feb 10
Crombie C, Burns WI, Karapetis C, Lowenthal RM, Kirsten F, Davidson JA, Abell F, Reece WHH, Iglesias J, de Souza P. A Randomized Phase II Trial of Gemcitabine and Either Day 1 or Day 8 Carboplatin for Advanced Non-Small Cell Lung Cancer. Asia Pacific Journal of Clinical Oncology, Published online 24 Feb 2009; 5: 24–31
Dutcher JP, de Souza P, McDermott D, Figlin RA, Berkenblit A, Thiele A, Krygowski M, Strahs A, Feingold J, Hudes G. Effect of Temsirolimus versus Interferon-α on Outcome of Patients with Advanced Renal Cell Carcinoma of Different Tumor Histologies. Medical Oncology 2009;26(2):202- 9. Epub 2009 Feb 20
Figlin RA, de Souza P, McDermott D, Dutcher JP, Berkenblit A, Thiele A, Krygowski M, Strahs A, Feingold J, Boni J, Hudes G. Analysis of PTEN and HIF-1α and Correlation with Efficacy in Patients with Advanced Renal Cell Carcinoma Treated with Temsirolimus Versus Interferon-α. Cancer 2009 Aug 15;115(16):3651-60
Khasraw M, Pavlakis N, McCowatt S, Underhill C, Begbie S, de Souza P, Boyce A, Parnis F, Lim V, Harvie R, Marx G. Multicentre phase I/II Study of PI-88, a heparanase inhibitor, in combination with docetaxel in patients with hormone refractory prostate cancer. Annals of Oncology 2009 Nov 16. [Epub ahead of print]
Chua YJ, Michael M, Zalcberg JR, Hicks RJ, Goldstein D, Liauw W, Price T. Antitumor effect of somatostatin analogs in neuroendocrine tumors. J Clin Oncol. 2010 Jan 20;28(3):e41-2; author reply e43-4. Epub 2009 Dec 14. PubMed PMID: 20008618.
124 Chua TC, Saxena A, Liauw W, Kokandi A, Morris DL. Systematic review of randomized and nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic chemotherapy for resectable colorectal liver metastases. Ann Surg Oncol. 2010 Feb;17(2):492-501. Epub 2009 Oct 24. PubMed PMID: 19856028.
Chua TC, Robertson G, Liauw W, Farrell R, Yan TD, Morris DL. Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery in ovarian cancer peritoneal carcinomatosis: systematic review of current results. J Cancer Res Clin Oncol. 2009 Dec;135(12):1637-45. Epub 2009 Aug 23. Review. PubMed PMID: 19701772.
Chua TC, Al-Mohaimeed K, Liauw W, Morris DL. Pseudomyxoma peritonei: a need to establish evidence-based standard of care--is this the right trial? Ann Surg Oncol. 2009 Oct;16(10):2675-7. Epub 2009 Jul 29. PubMed PMID: 19639367; PubMed Central PMCID: PMC2749180.
Chua TC, Liauw W, Robertson G, Morris DL. Establishing evidence for change in ovarian cancer surgery - proposing clinical trials of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer peritoneal carcinomatosis. Gynecol Oncol. 2009 Oct;115(1):166-8; author reply 168-9. Epub 2009 Jul 14. PubMed PMID: 19604568.
Chua TC, Liauw W, Morris DL. New treatments and outcomes in peritoneal carcinomatosis. Med J Aust. 2009 Jul 6;191(1):3-4. PubMed PMID: 19580525.
Chua TC, Liauw W, Morris DL. The St George Hospital Peritoneal Surface Malignancy Program-- where are we now? ANZ J Surg. 2009 Jun;79(6):416-8. PubMed PMID: 19566860.
Chua TC, Koh JL, Yan TD, Liauw W, Morris DL. Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. J Surg Oncol. 2009 Aug 1;100(2):139-43. PubMed PMID: 19544356.
Chua TC, Liauw W, Robertson G, Chia WK, Soo KC, Alobaid A, Al-Mohaimeed K, Morris DL. Towards randomized trials of cytoreductive surgery using peritonectomy and hyperthermic intraperitoneal chemotherapy for ovarian cancer peritoneal carcinomatosis. Gynecol Oncol. 2009 Jul;114(1):137-9; author reply 139. Epub 2009 Apr 14. PubMed PMID: 19368962.
Mohammad Hossein Pourgholami, Zhao Yan Cai, Lisa Wang, Semina Badar, Matthew Links, David Lawson Morris. Inhibition of cell proliferation, vascular endothelial growth factor and tumor growth by Albendazole. Cancer Investigation. 27:171-177, 2009
Nicole Mittmann, Heather-Jane Au, Dongsheng Tu, Christopher J. O’Callaghan, Pierre K. Isogai, Christos S. Karapetis, John R. Zalcberg, William K. Evans, Malcolm J. Moore, Jehan Siddiqui, Brian Findlay, Bruce Colwell, John Simes, Peter Gibbs, Matthew Links, Niall C. Tebbutt, Derek J. Jonker, Working Group on Economic Analysis of the National Cancer Institute of Canada Clinical Trials Group, Australasian Gastrointestinal Interest Group. Prospective cost-effectiveness analysis of Cetuximab in metastatic colorectal cancer: Evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 Trial. JNCI Journal of the National Cancer Institute Advance Access. Pub August 7, 2009, 101(17):1182-92, Sept 2, 2009
125 Shom Goel, Ehtesham Abdi, Craig R Lewis, Matthew Links, Steven Begbie, Philip Clingan, Vinod Ganju, Jane Beith. Phase II study of gemcitabine and docetaxel in combination for the treatment of metastatic breast cancer. Asia–Pacific Journal of Clinical Oncology 2009; 5: 32–38.
P H Graham, J L Graham. Use of deodorants during adjuvant breast radiotherapy: a survey of compliance with standard advice, impact on patients and a literature review on safety. J Med Imaging Radiat Oncol 2009;53(6):569-73.
EKA Millar, PH Graham, SA O’Toole, CM McNeil, L Browne, AL Morey, S Eggleton, J Beretov, C Theocharous, Ann Capp, E Nasser, JH Kearsley, G Delaney, G Papadatos, C Fox, RL Sutherland. Prediction of local recurrence, distant metastases and death following breast-conserving therapy in early-stage invasive breast cancer using a five biomarker panel. J Clin Oncol 2009; 27(28): 4701-8.
Yilmaz H, Millar EKA, Theocharous C, Graham P. Metachronous bilateral primary low-grade mucosa-associated lymphoid tissue (MALT) non-hodgkin’s lymphoma of the breast. Asia Pacific J Clin Oncol 2009; 5: 154-158
Graham PH, Martin RM, Browne LH . Communicating breast cancer treatment complication risks: when words are likely to fail. Asia Pacific J Clin Oncol 2009; 5(3): 193-199
Graham PH. Supraclavicular radiotherapy and lymphedema. Int J Radiat Oncol Biol Phys 2009;74 (5) :1627
Fang ZM, Tse RV, Marjoniemi VM, Kozlov S, Lavin MF, Chen H, Kearsley JH, Graham PH, Clarke RA. Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein. J Med Im Radiat Oncol 2009; (53):234-9.
Spry N, Bydder S, Harvey J, Borg M, Ngan S, Miller J, Graham P, Zissiadis Y, Kneebone A, Ebert M. Accrediting radiation technique in a multicentre trial of chemoradiation for pancreatic cancer. J Med Imaging Radiat Oncol 2009; 52(6):598-604.
Chapman N, Brighton T, Harris, Caplan GA, Braithwaite J, Chong BH. Venous thromboembolism: Management in general practice. Australian Family Physician 2009; 38; 36-40.
Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold, Bussel, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan, Sanz MA, Imbach P, Blanchette V, Kuhne T, Ruggeri M, George JN. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenia purpura of adults and children: Report from an international working group. Blood 2009; 113(11); 2386-2393.
Chong BH, Isaacs A. Heparin-induced thrombocytopenia: What clinicians need to know. Thrombosis and Haemostasis 2009; 101(2); 279-283.
Shantsila E, Lip GYH, Chong BH. Heparin-induced thrombocytopenia; A contemporary clinical
126 approach to diagnosis and management. Chest 2009; 132(6); 1651-1664. Chong BH. Primary immune thrombocytopenia: Understanding pathogenesis is the key to better treatments. Journal of Thrombosis and Haemostasis 2009; 7(2); 319-231.
5. Other published material
Kate Webber, Antoinette Fontela, Nina Bonner, Janet Bell, Joseph Bucci, Paul De Souza, Craig Lewis, Rina Hui, Peter Graham, Matthew Links. CRP predicts tolerance of treatment and overall survival with weekly carboplatin-paclitaxel and concomitant irradiation for locally advanced non-small cell lung cancer. ASCO 2009.
Melita K Kenealy, John F Seymour, Cowan Linda, Alvin Milner, Pratyush Giri, Shir-Jing Ho, Warwick Benson, Andrew Nicol, Philip Campbell, Ian Prosser, Craig Underhill, Ilona Cunningham, Anthony K. Mills, Jeffrey Szer, Peter Presgrave, Robin Filshie. The Tolerability of Combination Therapy with Thalidomide and 5-Azacitidine in Patients with Advanced Myelodysplastic Syndromes (MDS). Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 1749.
Roncolato F, Lee SH. The Utility of the Bone Marrow Trephine Biopsy in Acute Myeloid Leukemia Following Remission Induction Therapy. International Journal of Laboratory Hematology 2009 31:101- 102, (Abstract)
20th Asian Pacific Cancer Conference, Japan, 2009
You J, Fitzgerald A, Cozzi PJ, Zhao Z, Graham P, Russell PJ, Walsh BJ, Wilcox M, Li Y. Identification of potential biomarkers for prostate cancer in tears and serum using proteomic approaches.
RANZCR_AIR_ACPSEM Combined Scientific Meeting Brisbane, 22-25 Oct 2009
Ball D, Fisher R, Burmeister B, Poulsen M, Graham P, Penniment M, Vinod S, Krawitz H, Joseph D, Wheeler G, McClure B. Lung tumour volume and survival in patients with non-small cell lung cancer (NSCLC) treated by definitive radiotherapy (RT): TROG 9905. J Med Im Radiat Oncol 53 Suppl 1:A108
Australasian Society for Breast Diseases, Gold Coast October 2009 Ewan KA Millar, Peter H Graham, Sandra A O’Toole, Catriona M McNeil, Lois Browne, Adrienne L Morey, Sarah Eggleton, Julia Beretov, Constantine Theocharous, Ann Capp, Elias Nasser, John H Kearsley, Geoff Delaney, George Papadatos, Christopher Fox, Robert L Sutherland. Prediction of local recurrence, distant metastases and death following breast-conserving therapy in early-stage invasive breast cancer using a five biomarker panel.
Graham PH, Graham JL Proscription of deodorants during adjuvant breast radiotherapy: a survey of compliance, patient impact and evidence of safety.
World Lung Cancer Conference, San Francisco 31 July 2009
127 D Ball, R Fisher, B Burmeister, M Poulsen, P Graham, M Penniment, S Vinod, H Krawitz, D Joseph, G Wheeler, B McClure The complex relationship of lung tumor volume to survival in patients with non- small cell lung cancer (NSCLC) treated by definitive radiotherapy (RT): (Trans Tasman Radiation Oncology Group Study 9905). J Thoracic Oncol 4(9) Suppl 1:S335
Webber K, Fontela A, Bonner N, Bell J, Bucci J, De Souza P, Lewis C, Hui R, Graham P Links M. CRP predicts tolerance of treatment and overall survival with weekly carboplatin-paclitaxel and concomitant irradiation for locally advanced non-small cell lung cancer
MOGA 30th ASM ACT August 2009
Webber K, Fontela A, Bonner N, Bell J, Bucci J, De Souza P, Lewis C, Graham P Links M. CRP predicts tolerance of treatment and overall survival with weekly carboplatin-paclitaxel and concomitant irradiation for locally advanced non-small cell lung cancer. MOGA ASM ACT 2009. Asia Pacific J Clin Oncol 2009; 5(S1):A54
RANZCR/AIR/FRO/ACPSEM ASM Brisbane Oct 2009
D Ball, R Fisher, B Burmeister, M Poulsen, P Graham, M Penniment, S Vinod, H Krawitz, D Joseph, G Wheeler, B McClure. Lung tumour volume and survival in patients with non-small cell lung cancer (NSCLC) treated by definitive radiotherapy (RT): TROG 99.05.
6. Community Engagement
In May 2009, the CTU was one of 5 New South Wales trial units nominated by the Cancer Institute at the 2009 Premier’s Awards for Outstanding Cancer Research - for “Innovation in Clinical Trials”.
The event was held on Thursday evening 21 May at the Exhibition Centre at Darling Harbour.
128 WOMEN’s & CHILDREN’S HEALTH
DEPARTMENT OF WOMEN’s HEALTH
1. Departmental Staff
Head of Department Professor Michael Chapman MBBS, MD, FRCOG, FRANZCOG, CREI Professor of O&G, UNSW
Senior Medical Staff Assoc Professor Kate H. Moore MBBS, MD, FRCOG, FRANZCOG, CU Professor of O&G, UNSW Dr Gregory Davis MBChB, MD, FRACP Conjoint Senior Lecturer, UNSW Dr Emmanuel Karantanis MBBS, PhD, FRANZCOG, CU Conjoint Senior Lecturer, UNSW Dr Gregory Robertson MBBS, FRANZCOG, CGO Conjoint Senior Lecturer, UNSW Dr Gavin Sacks MBBS, DPhil, MRCOG, FRANZCOG Conjoint Senior Lecturer, UNSW Dr Margaret Booth MBBS, FRANZCOG Dr John Breen MBBS, FRANZCOG Dr Greg Cario MBBS, FRCOG, FRANZCOG Dr Danny Chou MBBS, FRANZCOG Dr Ludmilla Collins MBBS, FRANZCOG Dr Chandra Krishnan MBBS, FRANZCOG Dr Trent Miller MBBS, FRANZCOG Dr Michael O’Connor AM, MD BS, MHL, DCH, DDU, FRCOG, FRANZCOG, JP Dr James Opperman MBBS, FRANZCOG Dr Kenneth Roper MBBS, FRANZCOG Dr David Rosen MBBS, FRANZCOG Dr Steven Thou MBBS, FRANZCOG Dr Queeny Wong MBBS, FRANZCOG
Research Staff Senior Midwifery Research Fellow: Professor Caroline Homer PhD, RN, RM Professor of Midwifery, UTS Research Midwife: Lynne Roberts RN, RM
129 2. Research Grants
Australasian Gynaecological Endoscopy Society; 2009: $18,000 Danny Chou, Greg Cario, David Rosen. PULL APEX study. 2009
Australian Centre for Child Protection. 2009: $72,000. Briggs C, Homer CSE, Fowler C, Green J, Gray J, Brown N. Nurturing and Protecting Children: Nursing and Midwifery Curriculum Standards Project.
Australian Centre for Child Protection. 2009-2010: $180,000. Leap N, Fowler C, Homer CSE, Briggs C. Sowing the Seeds of Innovation in the Prevention of Child Abuse and Neglect: Midwifery and Child and Family Health Nursing.
3. Research Projects in Progress
Department of Women’s Health is a Collaborating Centre for the following international multicentre randomized controlled trials:
Study Organising Centre Chief Investigator
Twin Birth Study The Centre for Mother Infant and Child Research. Toronto, Canada Dr Jon Barrett
PROGRESS Women’s and Children’s Hospital, Adelaide Prof Caroline Crowther
PPROMT Dept O&G, RNSH Sydney Prof Jonathon Morris
ASTEROID Women’s and Children’s Hospital, Adelaide Prof Caroline Crowther
EECV Trial The Centre for Mother Infant and Child Research. Toronto, Canada Prof Eileen Hutton
Other studies • Validation Study of the Omron T9P in Pregnancy. Chief Investigator Prof Mark Brown • Patients and outcomes and the cost of nurses’ turnover in Australian hospitals. Chief Investigators Christine Duffield, Michael Roche, Caroline Homer and James Buchan. • A randomised controlled trial of caseload midwifery care – the M@NGO Project. Chief Investigators Sally Tracy, Michael Chapman, Caroline Homer. • The Birth Unit Design (BUD) Project. Chief Investigators Foureur MJ, Leap N, Davis D, Forbes I, Homer CSE • Obstetric placental risk assessment (OPRA). Chief Investigator Gregory Davis
130 4. Original Peer-Reviewed Publications
Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol 2009; 70:372-377.
Chambers, GM, Sullivan, EA, Ishihara, O, Chapman, MG, & et al. The economic impact of assisted reproductive technology: a review of selected developed countries. Fert Ster 2009; 91:2281-2294.
Kilani, S, Cooke, S, Kan, A, & Chapman, MG. Are there non-invasive markers in human oocytes that can predict pregnancy outcome? Reprod Biomed Online 2009; 18: 674 - 680.
Mcmurtrie, J, Catling-paul, C, Teate, A, Caplice, S, et al The St George homebirth program: An evaluation of the first 100 booked women. Aust N Z J Obstet Gynaecol 2009; 49:631 - 636.
Sullivan, EA, Moran, K, & Chapman, MG Term breech singletons and caesarean section: A population study, Australia 1991-2005. Aust N Z J Obstet Gynaecol 2009; 49:456 - 460.
King K, Smith S, Chapman M, Sacks G. Detailed analysis of peripheral blood natural killer cells in women with recurrent miscarriage. Hum Reprod. Epub 2009 Oct 9.
Homer CSE, Hanna E, McMichael AJ. Climate change threatens the achievement of the Millennium Development Goals for maternal health. Midwifery 2009; 25 (6): 606–612.
McMurtrie J, Catling-Paull C, Teate A, Caplice S, Chapman M, Homer CSE. An evaluation of the first 100 women booked on the St George Homebirth Program. Australian and New Zealand Journal of Obstetrics and Gynaecology 2009; 49: 631–636.
Homer CSE, Passant L, Brodie, PM, Kildea S, Leap, N, Pincombe J, Thorogood C. The role of the midwife in Australia: Views of women and midwives. Midwifery Int J. 2009, 25 (6): 673–681.
Adams J, Lui CW, Sibbritt D, Broom A, Wardle J, Homer CSE, Beck S. Women’s use of complementary and alternative medicine (CAM) during pregnancy: A critical review of the literature. Birth, 2009; 36: 237-245.
131 Homer CSE, Clement V, Peek, M, McDonnell, N, Sullivan E. Maternal mortality in Australia: what can we learn from stories of postpartum haemorrhage? Wom Birth. 2009; 22: 97—104.
Homer CSE, Henry K, Schmied V, Kemp L, Leap N, Briggs C. It looks good on paper: Transitions of care between midwives and child and family health nurses in New South Wales. Wom Birth. 2009, 22(2): 64-72.
Dahlen H, Homer CSE, Cooke M, Upton A, Nunn R, Brodrick B. ‘Soothing the ring of fire’: Australian women’s and midwives’ experiences of using perineal warm packs in the second stage of labour. Midwifery, 2009; 25: e39–e48.
Schmied V, Cooke M, Gutwein R, Steinlein E, Homer CSE. An evaluation of strategies to improve the quality and content of hospital-based postnatal care in a metropolitan Australian hospital. J Clin Nurs 2009; 18 (13): 1850–1861.
5. Presentations at Scientific Meetings/Conferences
National
1. Allen S, Homer CSE. Understanding safety culture in maternity services – a window to improving safety in maternity care. Improving the Delivery of Maternity Care Conference, Perth, February 2009.
2. Everitt L, Homer CSE. Midwives working with women – Addressing the challenges of non- voluntary relinquishment of newborns for midwives. Australian College of Midwives 16th Biennial National Conference, Adelaide, September. 2009.
3. Foureur M, Homer CSE, Leap N, Forbes I, Davis D. Development and testing of the Birth Unit Design Spatial Evaluation Tool (BUDSET) to assess optimality of birth environments. 14th Perinatal Society of Australia and New Zealand (PSANZ) Annual Congress, Darwin, March 2009.
4. Foureur, M., Ryan, C., Homer, C. S., and the BACI Consortium, Inconsistent Evidence: Analysis of Six National Guidelines for Vaginal Birth After Caesarean (VBAC), 14th Perinatal Society of Australia and New Zealand (PSANZ) Annual Congress, Darwin, March 2009.
5. Gray J, Homer CSE, Leap N. Midwifery students working with women: Relationships, learning and the follow through experience. Australian College of Midwives 16th Biennial National Conference, Adelaide, September. 2009.
132 6. Homer CSE, Johnson R, Foureur M, and the BACI Consortium. Next birth after caesarean section: Trends over 9 years in NSW. 14th Perinatal Society of Australia and New Zealand (PSANZ) Annual Congress, Darwin, March 2009.
7. Kwik M, Lee E, Chapman M. Spontaneous pregnancy rates following HyCoSy and HSG. Fertility Society of Australia Conference, Perth, WA
8. Ledang C, Kwik M, Chapman M. Long term follow-up study of the outcomes of 721 consecutive patients referred to an infertility clinic over a 3 year period. Fertility Society of Australia Conference, Perth, WA
9. Sacks G. Management of implantation failure. Fertility Society of Australia, Merck Serono Satellite Symposium, Perth 25th Oct 2009
10. Teate A, Homer CSE, Leap N. Introducing a group model of antenatal care –‘CenteringPregnancy’ – into an Australian maternity health setting. Improving the Delivery of Maternity Care Conference, Perth, February 2009.
11. Yang Y, Smith S, Chapman M, Sacks G. The role of peripheral blood natural killer cell analysis in women with repeated IVF failure. Fertility Society of Australia, Perth 26th Oct 2009
12. AGES XIX Annual Scientific Meeting/AAGL 3rd International Congress on Minimally invasive Surgery, Brisbane May 2009
• Operative laparoscopy complications in an advanced gynaecological endoscopy unit (SWEC) in 2008. Greg Cario, Danny Chou, David Rosen, Mark Carlton, Aoife O’ Neill • Does entry technique influence intra-abdominal adhesion development? Greg Cario, David Rosen, Danny Chou, Aoife O’ Neill • Laparoscopic Uterine artery ligation (LUAG): Laparoscopic Myomectomy of a 12cm fibroid. Chou D, Cario G, Rosen D, Carlton M, O’Neil A • Laparoscopic Uterine Artery Ligation(LUAG): Laparoscopic assisted myomectomy (LAM) of a 23X16X9cm multiple fibroid uterus. Chou D, Cario G, Rosen D, Carlton M, O’Neil A • Laparoscopic Uterine artery ligation (LUAG): Laparoscopic total hysterectomy for a 2500 gm uterus. Chou D, Cario G, Rosen D, Carlton M, O’Neil A • Laparoscopic Uterine Artery ligation(LUAG): The anterior approach. Chou D, Cario G, Rosen D, Carlton M, O’Neil A • Postoperative uterine perfusion following uterine artery clipping at laparoscopic myomectomy Rosen DMB • Fibroma in ectopic ovarian tissue. Georgiou C, Rosen D
133 13 AGES Pelvic Floor Symposium X Melbourne, August 2009
• Laparoscopic Uterosacral Ligament Suspension (LUSLS): Its role in the prevention of post hysterectomy vault prolapse. Greg Cario, Aoife O’Neil , David Rosen and Danny Chou, • Laparoscopic Uterosacral Ligament suspension for the prevention of Uterovaginal Prolapse associated with Burch Colposuspension, Greg Cario, Jennifer Anderson and Aoife O’Neil, David Rosen and Danny Chou • Laparoscopic High Anterior Paravaginal Repair and Burch Colposuspension: the SWEC technique. Greg Cario, David Rosen, Danny Chou and Aoife O’Neil
Local
1. Sacks G. Implantation and early pregnancy. FSA START course, Aug, Sydney
2. Sacks G. What on O&G registrar need to know about IVF. RANZCOG trainees course. Sydney Nov 2009
6. Community Engagement
1. Sacks G. Reproductive options for patients facing cancer. GPCE, 23 May, Sydney
134 DEPARTMENT OF UROGYNAECOLOGY
1. Departmental Staff
Head of Department Assoc. Prof. Kate H. Moore MBBS, MD, FRCOG, FRANZCOG, CU
Senior Consultant Staff Dr Emmanuel Karantanis MBBS, MD, FRCOG, FRANZCOG, CU
Research Staff Dr Colin Walsh MBBS, MRCOG, Senior Research Fellow Dr Su Sarma MBBS, MRCOG, Senior Research Fellow Dr Orla Teahan, MSC, PhD, Post Doctoral Fellow Dr Kylie Mansfield MSC, PhD, Lecturer
Detrusor Muscle Laboratory Supervisor: Dr Ying Cheng MSC PhD (Senior Research Officer)
Research Associates Ms Wendy Hayes, Physiotherapist Ms Janette O’Toole, Physiotherapist
Research Students Dr Colin Walsh MBBS, MRCOG, PhD Student
Nursing Research Staff Ms Wendy Allen BN, Clinical Nurse Specialist (part-time) Ms Anthea Reus BN, Masters of Nursing, Grad Cert Clinical Nursing, Clinical Nurse Specialist (part-time) Ms Anne Siddins, Research Registered Nurse (part-time) Ms Jeannette Werda Dip App Sc, Adv Dip Herb Med ND, Clinical Nurse Consultant (part-time) Ms Katrina Parkin Dip Nurs, Midwifery, Research Registered Nurse (part-time)
135 2. Research Grants
NHMRC (#508925); 2008 – 2010: $33,000 pa POPPY (Physiotherapy for Pelvic Organ Prolapse) Project
Commonwealth Government; 2008 – 2010: $35,000 pa Continence Outcomes Measures Validation and Clinical Translation Project
Pfizer Competitive Grants Program; 2009 –2010: US$75,000 New OAB Targets: ATP, Stretch, Tachykinins and Vanilloid Interaction in the Bladder Mucosa
NHMRC; 2009 – 2011: $140,000 per annum Non-neuronal ATP: Regulation of release and Action in the bladder
Int’l Urogynaecology Assoc; 2009 – 2010: $20,000US Low Count Bacteriuria and ATP Release in Refractory Detrusor Overactivity
3. Research Projects in Progress
Randomized controlled trial of cough test in performance of the TVT procedure: R. Shahab, C. Walsh, W. Allen, A. Wang, E. Karantanis, K. Parkin, K.H. Moore.
Use of the PFMT Motivation Questionnaire to predict response to pelvic physiotherapy: S. Sarma, W, Allen, C. Walsh, K. Parkin, E Karantanis, K. H. Moore.
ATP Release during cystometry in women with Detrusor Overactivity: Y. Cheng, K. Mansfield, C. Walsh, E. Burcher, K. H. Moore
An aliquot study of ATP release during cystometry in women with incontinence: Y. Cheng, K. Mansfield, C. Walsh, E. Burcher, K. H. Moore and W. Allen
ATP release during acute exacerbation of urge symptoms in relation to bacterial cystitis: C. Walsh, Y. Cheng, K. Mansfield, C. Walsh, E. Burcher, K. H. Moore and A. Siddins
Low grade bacteria uria in women with refractory detrusor overactivity: C. Walsh, Y. Cheng, K. Mansfield, C. Walsh, E. Burcher, K. H. Moore and A. Siddins
Randomized controlled trial of Electromagnetic Chair versus routine PFMT for stress incontinence: J. O’Toole, W. Hayes, W. Allen, E. Karantanis, K. H. Moore
136 Randomized controlled trial of PFMT versus control for women with mild to moderate vaginal prolapse: W. Hayes, J O’Toole, W. Allen, E. Karantanis, K. H. Moore
Randomized controlled trial of single use versus re-use catheters in patients who self-catheterize for bladder outflow obstruction: A Reus, E. Karantanis, H. Leek, K. H. Moore
Prospective observational study of success of detailed management plan for constipation by a Nurse Continence Advisor: J. Werda, H. Leek, V. Paton.
Prospective observational study of metformin therapy for insulin resistance in woman with truncal obesity and stress incontinence: E. Dorney, W. Allen, C. Walsh, K. H. Moore
Case – control study of demographic factors predisposing to anal incontinence in women with third degree obstetric tears: E. Karantanis, F Brims, K. Gardiner, V. Paton, D. Lubowski
Prospective observational study of the cost of faecal incontinence: V. Paton, C. Parker, D. Lubowski, K. H. Moore
4. Original Peer-Reviewed Publications
Sarma S, Thakkar K, Hayes W, Karantanis E, Hawthorn G, Moore KH. The Development of an Incontinence Treatment Motivation Questionnaire for patients undergoing Pelvic Floor Physiotherapy in the treatment of Stress Incontinence. Int. J Urogynaecol. 2009. 20:1085-1093
Sarma S, Ying, T, Moore KH. Long term vaginal ring pessary use: discontinuation rates and adverse events. Brit J Obstet & Gynae 2009, 116:1715 -21.
Sarma S, Hersch M, Siva S, Dietz H, Moore KH. Women who cannot contract their pelvic floor muscles – avulsion or denervation? Neurology & Urodynamics, 2009 28: 680-681
5. Other published material
Book Chapter: Moore KH, Hu TW, Subak L, Wagner TH, Duetekom, M. “Economics of Urinary & Faecal Incontinence, and Prolapse”. Report of World Health Organisation, Editors: Abrams P, Cardozo L, Koury S, Wein A. Health Publications Ltd., Plymouth. 2009:1687-1712.
137 6. Presentations at Scientific Meetings/Conferences
International
Cheng Y, Mansfield K, Burcher E,Moore KH. Stretch, acid, capsaicin and tachykinins as stimuli for ATP release from cultured pig urothelial and detrusor muscle cells. International Continence Society, San Francisco 2009
Walsh C, Allen W, Mukerjee C, Moore KH. Bacterial Cystitis in Refractory Idiopathic Detrusor Overactivity – an Unexpected Finding. International Continence Society, San Francisco 2009.
Sarma S, Hersch M, Siva S, Dietz HP, Moore KH. Women Who Cannot Contract Their Pelvic Floor Muscles – Avulsion or Denervation? The Pelvic Floor Neuroanatomy Study. International Continence Society, San Francisco 2009.
Cheng Y, Allan W, Walsh C, Mansfield KJ, Burcher E,Moore KH. ATP Release During Cystometry in Women with Detrusor Overactivity and Painful Bladder Syndrome: Contribution to “Urgency”? International Continence Society, San Francisco 2009.
Invited to Speak (“How Do We Prove The Urothelium is Intelligent” and “Providing Evidence Based Care for Mixed Incontinence”) International Consultation on Incontinence Research Society. Bristol. May 2009.
National
Moore KH. Is the current ‘definition’ of bacterial cystitis appropriate for women with coexistent lower urinary tract symptoms (LUTS)? Australian New Zealand Continence Journal. 2009: 15: 124-125. Continence Foundation of Australia. Adelaide. November 2009.
Shahad R, Sarma S, Karantanis E, Moore KH. Randomised control trial (RCT) of cough test versus no-cough test during the tension-free vaginal (TVT) procedure for stress urinary incontinence. Australian New Zealand Continence Journal. 2009: 15.122. Continence Foundation of Australia. Adelaide. November 2009.
7. Community Engagement
State
NSW State Training and Accreditation Committee of Royal Aust NZ College of Obstetrics and Gynaecology (RANZCOG) A/Professor Kate Moore serves on the State T&A Committee which meets quarterly to maintain training standards for all O&G registrars in NSW. Also serves as the Director of the Integrated Training Programme for St George Hospital, Lismore, Bankstown, Woollongong and Sutherland hospitals, to which our registrars rotate. Involves supervision of maintanence of training standards and high
138 quality registrar performance in all 5 hospitals. Important to insure that women in these hospitals are cared for professionally by all trainees.
National
RANZCOG Subspecialty Urogynaecology National Management Committee RANZCOG Subspecialty Urogynaecology Examiner A/Professor Kate Moore serves on the 6 person Urogynaecology subspecialty committee, which supervises correct training standards/ performance for all trainees in this subspecialty, meets quarterly by evening teleconference. Also serves as Examiner annually for the written and viva voce exams in the subspecialty.
Chairman Urogynaecological Society Of Australasia (UGSA) A/Professor Kate Moore developed the Constitution for this society and formulated the first executive committee: the purpose of UGSA is to promote evidence based medicine in this subject.
Continence Foundation Of Australia (CFA) A/Professor Kate Moore served as Editor for the Continence Journal of Australasia, now Associate Editor. Also serves on Scientific Advisory Board of the CFA, and is frequently asked to serve on the Organising Committee for the Annual CFA scientific meeting. The CFA is the national “peak body” for the dissemination of information about urinary and faecal incontinence to the Community in Australia.
International:
World Health Organisation: International Consultation On Incontinence A/Professor Kate Moore serves as the Chairman of one of the 19 committees of this WHO sponsored consensus conference which meets every four years in Europe, followed by the production of a definitive Monograph on the subject of incontinence.
139 DEPARTMENT OF PAEDIATRICS
1. Departmental Staff*
Head of Department Dr. Bob Fonseca MBBS FRACP MMed (ClinEpid)
Senior Staff Dr. Ana Dosen MBBS FRACP Dr. Adrienne Moline MBBS FRACP Dr. Anthony Epstein MBBS FRACP Dr. Charles Scarf MBBS FRACP Dr. Con Papadopoulos MBBS FRACP, M Hlth Mgt, Grad Cert QI Dr. Kylie Yates MBBS FRACP MMed (ClinEpid) Dr. Maria Craig MBBS PhD FRACP MMed(ClinEpid) Assoc. Prof (UNSW) Dr. Mary-Louise Freckman MBBS FRACP, HGSA (Cert) Dr. Rani Sachdev MBBS FRACP, HGSA (Cert) Dr. Scott Dunlop MBBS FRACP
All paediatricians conjoint teaching appointments with the UNSW Faculty of Medicine
2. Research Grants#
How do enteroviruses cause type 1 diabetes? Craig ME, Rawlinson WD Leung KC $80 000 Financial Markets for Children
Viral triggers of autoimmunity and T1DM: a prospective study of at risk children Craig ME 2008 to 2010 $152 000 NHMRC Project Grant (#510258)
Viral triggers of autoimmunity and type 1 diabetes Craig ME 2007 to 2011 $44 500 NHMRC Career Development Award (#455363)
How enteroviruses cause cellular and functional damage in insulin-producing -cell Leung KC, Craig ME, Rawlinson WD 2009 $14 000 Rebecca Cooper Research Foundation
3. Research Projects in Progress
Vitamin D at birth and bone mineral density in childhood: a follow up study (Craig ME, Diamond T)
140 4. Original Peer - Reviewed Publications
Wolfsdorf J, Craig ME, Daneman D, Dunger D, Edge J, Lee W, Rosenbloom A, Sperling M, Hanas R. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes. Suppl 12:118-33, 2009
Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatr Diabetes. Suppl 12:3-12, 2009
Leung KC, Xu A, Craig ME, Martin A, Lam KS, O’Sullivan AJ. Adiponectin isoform distribution in women--relationship to female sex steroids and insulin sensitivity. Metabolism 58(2):239-45, 2009
Craig ME Trends in type 1 diabetes in Australia. Diabetes Management Journal, 29: 32, 2009
Howard J, Hall B, Brennan LE, Arbuckle S, Craig ME, Graf N, Rawlinson W. Utility of newborn screening cards for detecting CMV infection in cases of stillbirth. Journal of Clinical Virology 44:215-218, 2009
Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clinical Endocrinology 70:372-277, 2009
Craig ME, Wong C, Alexander J, Maguire AM, Silink M. Delayed referral of new-onset type 1 diabetes increases the risk of diabetic ketoacidosis. Med J Aust. 190(4):219, 2009
Craig ME, Huang CY. Type 2 diabetes in childhood: incidence and prognosis. Paediatrics and Child Health. 9(7):321-326, 2009
Catanzariti L, Faulks K, Moon L, Waters AM, Flack J, Craig ME. Australia’s national trends in the incidence of Type 1 diabetes in 0–14 year olds, 2000–2006. Diabetic Medicine 26, 596–601, 2009
Agero AL, Lahmar JJ, Holzborn RM, Martin LK, Freckmann ML, Murrell DF. Navus of Ota presenting in two generations: a mother and daughter J Eur Acad Dermatol Venereol 2009 Jan;23(1): 102-4 Eput 2008 Apr 14
141 5. Presentations at Scientific Meetings/Conferences
International
Dr Maria Craig Indian Society of Pediatric Endocrinology (ISPAE) Biennial Meeting – New Delhi ,India 1. Obesity Management: Mission Impossible? 2. Diabetes: Pumps and Loops
ISPAE Pediatric Endocrine Training Program – New Delhi ,India 1. Neonatal Endocrinology, 2. Thyroid Disorders in Childhood
Indonesian Paediatric Endocrine Society Pediatric Diabetes Update - Bali, Indonesia 1. A new expression of diabetes: Double Diabetes; 2. Diabetes Complications
Asia Pacific Paediatric Endocrine Society Fellows’ Meeting, Ayutthaya, Thailand 1. Disorders of Calcium and Vitamin D in Childhood
National
Dr Ana Dosen Poster presentation ASCIA Scientific Meeting 2009 Food challenges in allergic children: review of practise and outcomes. Food challenges were performed in a standardised fashion to access if children had become tolerant to previous allergic foods. There were very few reactions in the cohort of 80 over 12 months.
142 AGED & COMMUNITY SERVICES
DEPARTMENT OF AGED CARE
1. Departmental Staff
Head of Department Peter Smerdely MBBS (Hons) MPH PhD FRACP Director Department of Aged Care, St George Hospital Co Director, Aged & Extended Care, Central Health Network Network Executive Clinical Director, Central Health Network Conjoint Associate Professor UNSW
Senior Medical Staff Litsa Morfis MBBS FRACP Conjoint Lecturer, UNSW
Chris Dedousis MBBS FRACP Conjoint Appointment with Southcare, Sutherland Hospital Conjoint Senior Lecturer, UNSW
Sarah Baldwin MBBS FRACP Conjoint Lecturer, UNSW
Tony Youssef BSc (MED) MBBS FRACP Conjoint Appointment with Southcare, Sutherland Hospital
Nicholas Cordato MBBS (Hons 1) FRACP PhD Conjoint appointment with CRAGS, Calvary Hospital
Grant Pickard MBChB FRACP Appointed to Medical Assessment Unit
Yun Xu MBBS FRACP Conjoint appointment with CRAGS, Calvary Hospital
Frank Yan BSc (MED) MBBS FRACP
143 2. Community Engagement
All staff members are actively involved with the community. Regular lectures are given to groups associated with Alzheimer’s Australia, Department of Health and St George Hospital.
144 DEPARTMENT OF REHABILITATION MEDICINE
1. Departmental Staff
Head of Department Dr John Estell MBBS., BSc., MSpMed., FAFRM(RACP)
Senior Consultants A/Prof Andrew Cole MBBS(Hons) FAFRM(RACP) FACRM Conjoint Assoc Prof, School of Community Medicine UNSW
Dr Scott Hannan MBBS, BMedSci., FAFRM(RACP) FACRM Conjoint Senior Lecturer UNSW
Dr Kenneth Chan MBBS., BSc(Med) FAFRM(RACP)
2. Research Projects in Progress
Cost Benefit of Rehabilitation Care On-Site versus Off-site Rehabilitation in Stroke On-Site versus Off-site Rehabilitation in Orthopaedic Conditions Interventional Spasticity Management Rehabilitation Intensity of Therapy The Association between Team Characteristics, Performance and Human Resource Management in Rehabilitation Teams
3. Original Peer-Reviewed Publications
Kohler F. Dickson H. Redmond H. Estell J. Connolly C. Agreement of Functional Independence Measure Item Scores in Patients Transferred from One Rehabilitation Setting to Another. European Journal of Physical & Rehabilitation Medicine. 2009; 45(4):479-85
145 4. Other published material
Clinical Practice Guidelines for the Management of Adult Gliomas: Astrocytomas and Oligodendrogliomas (Cancer Council of Australia/Australian Cancer Network/Clinical Oncological Society of Australia) ISBN: 978-0-9775060-8-8 August 2009 Chapter 13 “Rehabilitation” pp. 191 – 197
5. Presentations at Scientific Meetings/Conferences
International
“The Cost Benefit Equation for Inpatient Rehabilitation” 2009 AFRM/NIRR/NZRA Interdisciplinary Rehabilitation Medicine Conference Dr John Estell
“Profile of a Metropolitan Amputee Clinic” 2009 AFRM/NIRR/NZRA Interdisciplinary Rehabilitation Medicine Conference Dr John Estell
“A Decade of Cancer Rehabilitation in South Western Sydney” 2009 AFRM/NIRR/NZRA Interdisciplinary Rehabilitation Medicine Conference Dr John Estell A/Prof A Cole
“Evidence for Effectiveness of Post Acute Cancer Rehabilitation” 2009 AFRM/NIRR/NZRA Interdisciplinary Rehabilitation Medicine Conference A/Prof Andrew Cole
“Cancer and Rehabilitation” 11th National Conference, Chinese Society of Physical Medicine & Rehabilitation, Shenyang September 2009 A/Prof A Cole
146 ALLIED HEALTH SERVICES
DEPARTMENT OF NUTRITION & DIETETICS
1. Departmental Staff
Head of Department Janet Bell BSc MNutr Diet APD, Cert Bus Management, Dip. Leadership & Management
Senior Staff Maria Chan BSc (Hons), MNutr diet, Adv APD, Grad Dip in Health Sc, Cert Bus Management Science (Exercise & Sport), Cert Business Management Nazy Zarshenas BSc, MNutr diet APD Katja Jukkola BSc, MNutr diet APD Nina Bonner BSc, MNutr diet APD Alex McClelland BSc, MNutr diet APD Lauren Wood BSc, Nutr diet APD Helen Dragicevich BSc, Nutr diet APD Natasha Yule BNutr Diet (Honours), APD Brielle Gosch BSc(Nutrition, Hons I) , APD, AN Kendell Ingram B.Nutr. Diet (Hons), APD, Dip. Bus Management
Junior Staff Rachel Pons BNutr Diet, APD Julia Phillips BSc, Nutrition and Exercise Science M Nutr Diet, APD Daniela Mondello BSc, Nutr diet APD Amber Raco BSc,M Nutr Diet, APD Nella Puz BSc, MNutr diet APD Jocelyn Birdsall BSc, MNutr Diet, APD, AN Lynelle Thomson BSc, Nutrition (honours)
2. Research Projects in Progress
Ellis J. Nutrition Clinical Outcomes in Palliative Care-PhD. Chan M. Nutrition management of patients with pre-dialysis chronic kidney disease (CKD) Zarshenas N. ASAP Study Audit of Severe Acute Pancreatitis feeding practices A prospective observational multicentre study of nutritional therapy in severe acute pancreatitis patients in Australasia.
147 3. Original Peer-Reviewed Publications
Zarshenas N. Nutrition and gastrointestinal quality of life assessment post Roux-en-Y gastric bypass, sleeve gastrectomy and adjustable gastric banding. Obesity Surgery 2009 19:953-1076.
Pons R, Whitten K, Woodhead H, Leacha S. Dietary intakes of children with Crohn’s disease. Pons R et al. Brit J Nutrition 2009; 102: 1052-1057
Zarshenas N, Jorgensen J. Prevalence of Nutrient deficiencies in Bariatric Patients. Nutrition 2009; 25: 1150-1156
Fry, K. et al. Development of Evidence Based Guidelines for the Nutritional Management of Adult Kidney Transplant Recipients. Journal of Renal Nutrition 2009; 19(1):101-104
4. Presentations at Scientific Meetings/Conferences
International
Zarshenas N. Nutrition and gastrointestinal quality of life assessment post Roux-en-Y gastric bypass, sleeve gastrectomy and adjustable gastric banding at the International Federation for the Surgery of Obesity and Metabolic Disorders in Paris. August 26-29th 2009
Chan M. Chronic kidney disease diet management and the Subjective Global Assessment workshop at the Parenteral and Enteral Nutrition Society of Asia (PENSA) Congress- PENSA 2009. Kuala Lumpur. June 5 - 7, 2009.
5. Community Engagement
Bell J –Co chair of the Greater Metropolitan Clinical Taskforce (GMCT) for Home Enteral Nutrition Bell J- Member of the Nutrition and Dietetics Advisors Group to the Department of Health Chan M-Executive member of the GMCT Renal Service Network Executive & Chronic Kidney Disease (CKD) and Transplant committees. Chan M- Member of the NSW Health Chronic Disease prevention sub-group (CKD) committee Ingle J- Executive member on the endocrine GMCT network
148