Simpleware Software Solutions for Life Sciences from 3D Images to Models Applications in Life Sciences

Simpleware Software Solutions for Life Sciences From 3D Images to Models Applications in Life Sciences

Orthopedics Product Design & Analysis Cardio & Respiratory Systems

Accurate Anatomical Consumer Products Physiological Flow Models and Wearables Analysis • Automated and semi-automated • Customize product designs to • Reslice images along vessels tools to segment anatomies individual anatomies and airways • Combine CAD implants and • Virtually check the fit and • Combine anatomical data with anatomical data function for devices including stent models • Accurately quantify bone electronic wearables • Mesh boundary layers and add geometries • Export models to simulate real- custom inlets and outlets for • Export multi-part FE/CFD world performance fluid flow analysis meshes to solvers • Gain better insight for future • Quantify vessels with centerline products by analyzing network tools real anatomies

EM & Neuromodulation Medical Device R&D Anatomical 3D Printing

Human Body Models Device and Image High-Quality STL for Simulation Integration Production • Use automated and/or semi- • Rapidly integrate CAD devices into • Print medical devices and automated segmentation tools CT/MRI scans anatomical parts from scans • Integrate CAD designs like MRI • Research human/device • Generate robust STL files ready coils or electrodes with image data interactions for 3D printing • Easy-to-use registration tools for • Automate repeatable operations • Conforming interfaces for multi- positioning devices with scripting material printing • Generate and export simulation- • Simulation-ready meshes suitable • Use 3D printed models as a ready meshes for analyzing device performance teaching aid From Image Processing through to Model Generation

3D Image Progressing in Simpleware ScanIP

Import & Registration Visualization Image Processing Modalities Volume rendering Image and mask filters

• MRI • GPU rendered • Noise reduction • CT • Combine with surface/mask/ • Smoothing/morphological filters • Micro-CT mesh renderings • Align, rescale and resample • Ultrasound Object visualization • Robust Boolean operations • Confocal microscopy • 3D live mode for instant updates Segmentation • 2D X-ray images* • Range of 2D and 3D • Threshold, floodfill and painting Formats visualization options • Interactive 3D editing tools • Overlay surface contours in 2D • 3D & 4D* DICOM • Advanced region-growing tool • Interactive image reslicing with • 2D image stacks (BMP, • Contour-based magnetic lasso multiplanar reconstruction mode JPEG, TIFF...) • Tools for handling poor contrast, • Raw image data (RAW, VOL…) Animations artefacts and low quality data • 3D wrap tool for scaffold-based Options • Rotate, clip and fly-through segmentation • Export video files • Co-registration of multiple 2D • Split tool to separate parts and/or 3D datasets Exports • Greyscale-based slice-to-slice • Store and manage DICOM tags • Generate and share 3D PDFs propagation and interpolation • Anonymization • Generate Virtual X-rays* • Local surface correction to • Compatible with PACS* compensate for artefacts • DICOM

The Simpleware Solution Improve Life Sciences Workflows Synopsys’ SimplewareTM software provides an industry-leading, Simpleware software is accessible to both beginners and more comprehensive 3D image processing platform for handling advanced users. The intuitive interface provides quick-and-easy 3D scan data. Accurately process images with a wide range of access to a range of powerful tools, including fully automated tools for visualizing data, obtaining image statistics and carrying anatomy-specific segmentation. The AI/ML tools dramatically out segmentation, right through to generating 3D printing and streamline workflows for pre-surgical planning and medical simulation-ready models. device design, making it straightforward to save time without compromising on accuracy.

*Only available in Simpleware ScanIP Medical From Image Processing through to Model Generation

Auto Segmenter Modules**

Measurements & Surface Model/Mesh Simpleware AS Cardio Statistics • Fast creation of STLs ready for Heart segmentation and landmarking 3D printing Interactive tools • From CT: Aorta, Ventricles, Atria, • Smoothing that preserves Pulmonary Artery, Myocardium, • Simple quick statistics and volume and topology and Coronary Arteries measurements • High-quality triangulation • Generate and probe (no need for fixing or post- Simpleware AS Ortho centerline networks processing) Hip segmentation and landmarking • 2D / 3D shape fitting and statistics • Guaranteed watertight surfaces • Wall thickness analysis • Feature-based mesh decimation • From CT: Pelvis, Proxmial Femurs, and Sacrum Statistics framework • Conforming surfaces between multiple parts Knee segmentation and landmarking • Thoroughly interrogate image • Multiple export formats supported data, generated models, or • From CT: Femur, Tibia, Fibula, • Advanced options to control centerlines Patella and Fabella (if present) minimum edge length, change • Extensive range of metrics rate, maximum error... • From MRI: Fibula, Patella, Femur • Highly flexible for creating and cartilage, Tibia and cartilage • Mesh quality histogram to inspect custom statistics templates generated mesh Ankle segmentation and landmarking • Generate PDF reports describing your data • From CT: Talus, Calcaneus, Tibia, and Fibula

All modules use fully automated AI- based machine learning

Have Confidence in Your Product Designs Customize your Workflow with Scripting Simpleware software is ideal for rapidly testing out different design Simpleware software offers many ways to help save time and iterations involving consumer products and the human body. effort, such as as a ‘My tools’ tab and scripting. All Simpleware Achieve reliable results every time with straightforward image functionality is accessible from a fully documented scripting API processing, measurements, and export of robust STL and NURBS with bindings available for Python and C#. Use this API to automate CAD files. Generate guaranteed high-quality FE meshes to evaluate repeatable workflows, build wizards and integrate custom plugins. biomechanical performance under real-world conditions. Generate code without any prior experience by using the macro recording functionality. From Image Processing through to Model Generation

Working with Computer-Aided Design (CAD) FE/CFD Volume Meshing

Simpleware CAD Simpleware NURBS** Simpleware FE • Fast and easy-to-use tools to • Create NURBS models for use in • Conforming multi-part combine CAD and image data CAD packages volume meshes • Import CAD files (STL, STEP, IGES) • Automated NURBS patch fitting • Feature-based and user-defined • Automatic fixing of erroneous CAD • Choice of algorithms mesh refinement data on import • Highly accurate conversion • Per-part meshing controls • Automatic snap or landmark- • Inspection tool to check models • Define contacts and node sets based registration • Models suitable for further design • Hounsfield material mapping • Surface deviation analysis for work/simulation for FE exports comparing objects • Export as STEP or IGES • Boundary layer meshing • Robust Boolean operations • Dedicated native exports for • Surface filters to smooth, Simpleware Design all major solvers decimate, resurface, fill holes Link** • Optimize element qualities • Surface editing tools to group/ against a choice of metrics • Synchronize models with ungroup, extrude, hollow, clip • Import existing meshes and SOLIDWORKS® • Sweep pipes/tubes along assign material properties • Import, export, and position parts centrelines • Segmentation checker to identify or assemblies • Preserve CAD edges when and fix problematic regions combined with image data • Automatically update design before meshing changes made in SOLIDWORKS® • Mesh quality histogram to inspect generated mesh

Integrate Image and Design Data From Image to Mesh Unique capabilities allow you to combine computer-aided design Simpleware software offers a direct route from image data to (CAD) models within 3D image data to capture realistic anatomical simulation. Generated meshes are ready to use in the FE/CFD details whilst accurately maintaining the design features of the solver of your choice, with extensive options for tailoring your CAD data. Avoid the challenge of combining CAD and image models to different simulation requirements. Rely on software data by using Simpleware software, with additional options for that generates simulation-ready models, with no need for post- synchronizing models with SOLIDWORKS®. processing or fixing. Export directly to all major solver formats.

**Not available in the Linux operating system Custom Model Generation and Services Expert Support for your Requirements Our service team can generate models for any application. We All licenses come with full support from our team of experts. Our will work with you to develop a model, or series of models, that engineers can help you develop your unique workflows, ensuring are tailored to your specific needs. This can be based on your your use of the software is as efficient as possible, and your final own scan data or we can work from our library of high resolution output matches your requirements. Our support is offered via image datasets. email, phone or web-meetings, or we can even visit you on-site. Contact us if you have any questions. Training at All Levels Receive step-by-step training on all areas of Simpleware software. Try Simpleware Software We offer classroom training courses at local Synopsys offices or Try the software for yourself with a free evaluation version, at your site, as well as customized one-to-one sessions at your available on our website. The trial is fully functional and gives you place of work, or through web meetings. Our interactive courses access to the complete Simpleware software suite, full range of include a combination of lectures. demos and hands-on tutorials. tutorials and technical support.

Simpleware Software Solutions The Simpleware product group at Synopsys develops an industry-leading 3D image processing platform for the visualization, quantification and conversion of 3D scan data (MRI, CT, micro-CT...) into high quality design, simulation and 3D printing models. Simpleware software is used in the Life Sciences, Clinical Applications, and Materials & Manufacturing. Easy-to-learn and use, the software offers a robust bridge between the latest imaging technologies and multiple design and simulation applications.

For more information, go to www.synopsys.com/simpleware

Email: [email protected]

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