<<

THE ROLE OF AND ETHYLENE IN ADVENTITIOUS FORMATION IN AND TOMATO

BY

POORNIMA SUKUMAR

A Dissertation Submitted to the Graduate Faculty of WAKE FOREST UNIVERSITY GRADUATE SCHOOL OF ARTS AND SCIENCES

in Partial Fulfillment of the Requirements

for the Degree of

DOCTOR OF PHILOSOPHY

In the Department of

May 2010

Winston-Salem, North Carolina

Approved By:

Gloria K. Muday, Ph.D., Advisor

Examining Committee:

Brenda S. J. Winkel, Ph.D., Chair

Susan E. Fahrbach, Ph.D.

Anita K. McCauley, Ph.D.

Brian W. Tague, Ph.D.

ACKNOWLEDGMENTS

“Live as if you were to die tomorrow. Learn as if you were to live forever.”

Mohandas Gandhi

First and foremost, I would like to thank my advisor Dr Gloria Muday for all her help with scientific as well as several aspects of my graduate student life. I appreciate your constant encouragement, support, and advice throughout my graduate studies. I owe my passion for science and teaching to your incessant enthusiasm and challenges.

I am grateful to my committee members, Dr Brian Tague, Dr Susan Fahrbach, Dr

Anita McCauley, and Dr Brenda Winkel for their encouragement, and assistance. I am indebted to you for providing valuable suggestions and ideas for making this project possible.

I appreciate the friendship and technical assistance by all my lab mates. In particular, I like to thank Sangeeta Negi for helping me with tomato research and making the lab more fun. I am grateful to Dan Lewis for his advice and help with figuring out imaging and molecular techniques, and Mary Beth Lovin for her sincere friendship and positive thoughts. I thank Hanya Chrispeels, Jonathan Isley, and Monica Jenks for being there for me everyday. I also acknowledge all the financial support for travel, facilities and opportunities provided by the Department of Biology.

I am obliged to my father Sukumara Kurup, my mother Dr Sujatha, my brother Dr

Kumar, my sister in law Dr Menon, my twin Dr Sukumar, and my brother in law Dr

Mohanan for their relentless love, encouragement, and support. They are my ideals and I

hope I can be as successful as them one day. Finally, I like to thank the higher power for guiding me, giving me strength, and for helping me making the right choices.

ii TABLE OF CONTENTS

ACKNOWLEDGMENTS………………………………………………………………...ii

TABLE OF CONTENTS………………………………………………………………...iii

LIST OF TABLES………………………………………………………………………..vi

LIST OF FIGURES……………………………………………………………………...vii

ABSTRACT……………………………………………………………………………...ix

CHAPTER I……………………………………………………………………………….1

INTRODUCTION………………………………………………………………...1

Environmental factors regulate adventitious root formation……………...1

Development of adventitious ………………………………………..3

Auxin transport, synthesis, and signaling regulates

development……………………………………………………………….4

Positional specificity of lateral root formation……………………………7

Ethylene signaling and synthesis regulates root development…………….8

Treatment with exogenous alters adventitious root formation…9

Positional specificity of adventitious root formation…………………….11

Auxin-ethylene crosstalk involved in adventitious root formation………12

Use of genetics to study adventitious root formation……………………13

Literature cited…………………………………………………………...15

CHAPTER II……………………………………………………………………………..26

Polar auxin transport mediated by ABCB19 and PIN1 regulates adventitious root

formation in Arabidopsis.

iii Abstract…………………………………………………………………..27

Introduction………………………………………………………………28

Results……………………………………………………………………33

Discussion………………………………………………………………..62

Methods…………………………………………………………………..69

Literature cited…………………………………………………………...75

CHAPTER III……………………………………………………………………………85

Auxin-ethylene cross talk drives adventitious root formation in Arabidopsis

Abstract…………………………………………………………………..86

Introduction………………………………………………………………87

Results……………………………………………………………………92

Discussion………………………………………………………………118

Methods…………………………………………………………………123

Literature cited………………………………………………………….129

CHAPTER IV…………………………………………………………………………..136

Genetic dissection of the role of the ethylene in regulating auxin-dependent lateral

and adventitious root formation in tomato

Abstract…………………………………………………………………137

Introduction……………………………………………………………..138

Results…………………………………………………………………..143

Discussion………………………………………………………………165

Methods…………………………………………………………………171

Literature cited………………………………………………………….175

iv CHAPTER V…………………………………………………………………………...183

CONCLUSION…………………………………………………………………183

Literature cited………………………………………………………………….195

APPENDIX……………………………………………………………………………..198

Introduction……………………………………………………………………..198

Results…………………………………………………………………………..200

Discussion………………………………………………………………………208

Methods…………………………………………………………………………210

Literature cited………………………………………………………………….212

CURRICULUM VITAE………………………………………………………………..213

v LIST OF TABLES

Table I-I: Effect of application of different hormones on adventitious root formation...10

Table II-I: Auxin from the shoot is important for adventitious root formation………...39

Table II-II: Root excision alters ABCB19:GFP fluorescence…………………………..55

Table A-I: Changing local auxin maxima from apical end to basal end changes the position of adventitious root formation…………………………………………………203

vi LIST OF FIGURES

Figure II-1: Removal of basal portion of and root increases adventitious root

formation in Arabidopsis………………………………………………………………...34

Figure II-2: Adventitious roots emerge from pericycle tissues of the hypocotyl………35

Figure II-3: Effect of scr1 and shr1 mutations on adventitious root formation………...38

Figure II-4: The effect of IAA on adventitious root formation…………………………41

Supplemental Figure II-1: Free IAA levels…………………………………………...45

Figure II-5: Auxin signaling and transport are required for adventitious root

formation…………………………………………………………………………………46

Supplemental Figure II-2: Transcript abundance of IAA signaling and IAA transport

genes……………………………………………………………………………………..49

Figure II-6: PIN1 transcription and pABCB19::ABCB19:GFP protein accumulation is

enhanced with excision…………………………………………………………………..53

Figure II-7: Phosphorylation regulates localization of adventitious roots……………...58

Figure III-1: Ethylene negatively affects adventitious root formation and is induced with

excision…………………………………………………………………………………..93

Figure III-2: Ethylene can inhibit auxin induction of adventitious root formation……..97

Supplemental Figure III-1: Adventitious roots formed in intact or root excised in wild

type and, etr1-1...... 100

Figure III-3: Ethylene inhibits IAA transport and free IAA levels in …….102

Figure III-4: Flavonoids are induced with excision and negatively regulates adventitious

root formation…………………………………………………………………………..106

vii Figure III-5: Ethylene induces flavonoids in hypocotyls and effect of ethylene on

adventitious root formation is partially dependent on flavonoids……………………...109

Supplemental Figure III-2: Relative transcript levels of CHS in Col and eto1-1…….113

Figure III-6: Ethylene regulation of auxin transport proteins mediating auxin transport required for adventitious root formation………………………………………………..115

Figure IV-1: Lateral root formation in tomato is influenced by mutations that alter ethylene signaling and synthesis. Roots were grown for 8 days on nutrient agar……...144

Figure IV-2: ACC reduces root initiation in Pearson, but not in the Nr mutant………147

Figure IV-3: Ethylene enhances adventitious root formation in tomato hypocotyls…..151

Figure IV-4: In tomato roots acropetal and basipetal IAA transport are positively

regulated by ethylene…………………………………………………………………...154

Figure IV-5: Ethylene alters basipetal auxin transport in tomato

hypocotyls.……………………………………………………………………………...157

Figure IV-6: In tomato roots free IAA content is reduced two days after 1 µM ACC

treatment………………………………………………………………………………..160

Figure IV-7: Effect of ethylene on free IAA content in tomato hypocotyls…………...161

Figure IV-8: Nr has altered responses to auxin in both lateral and adventitious root

formation………………………………………………………………………………..163

Figure V-1: Model for excision induced adventitious root formation…………………190

Figure V-II: model for excision induced adventitious root formation…………...192

Figure A-1: Shifting auxin maxima from apex to base of hypocotyl explant can change

the position of adventitious root formation and auxin accumulation…………………..201

Figure A-2: Acropetal auxin transport can be observed after polarity reversal………..206

viii ABSTRACT

Sukumar, Poornima

ROLE OF AUXIN AND ETHYLENE IN ADVENTITIOUS ROOT FORMATION IN

ARABIDOPSIS AND TOMATO

Dissertation under the direction of Gloria K.Muday, Ph.D., Professor of Biology

Adventitious roots emerge from aerial plant tissues. Although important for clonal

propagation of commercially important crop species, few studies have explored the

mechanisms driving the development of these roots. This thesis research explored the

hormonal controls and molecular mechanisms of adventitious root formation in

Arabidopsis thaliana (Arabidopsis) and Solanum lycopersicum (tomato). Removal of the

hypocotyl base and root from Arabidopsis seedlings enhanced the frequency of

adventitious root formation. ACC treatment and mutations that cause enhanced ethylene

synthesis reduced adventitious root formation in Arabidopsis, but enhanced adventitious root formation in tomato, with opposite effects found in ethylene insensitive mutations.

These results are consistent with ethylene oppositely regulating adventitious root

formation in these two species, while auxin has a similar stimulatory effect on

adventitious root formation in both. Root excision increases both adventitious root

formation and auxin transport. Additionally, local increases in auxin induced reporter

expression after excision precede adventitious root formation and predict the position of

root formation. These results indicate that local auxin accumulation due to changing

transport may drive adventitious root formation. Moreover, the auxin transport proteins

ABCB19 and PIN1, are required for efficient adventitious root formation. Transcript

ix levels of PIN1 increased with root excision in hypocotyls, while neither ABCB19 transcripts nor pABCB19:GFP fluorescence was found to change. In contrast, pABCB19::ABCB19:GFP fluorescence was increased in excised Arabidopsis hypocotyls, suggesting an increase in protein accumulation through post-transcriptional mechanisms.

A protein phosphatase inhibitor decreased ABCB19 accumulation, reduced auxin transport and accumulation, and altered location of adventitious root formation, suggesting that phosphorylation might modulate the ABCB19 protein abundance and/or activity. In addition, ethylene inhibits basipetal auxin transport in hypocotyls of

Arabidopsis in an ABCB19 dependent manner. Excision and elevated ethylene levels enhanced the accumulation of transcripts encoding the flavonoid biosynthetic enzyme chalcone synthase, as well as flavonoids metabolites, which have previously been shown to regulate auxin transport. The tt4 mutant, which lacks flavonoids, had altered adventitious root formation and was insensitive to ACC treatment. These identify changes in auxin transport, through altered accumulation of transport proteins and transport regulators, as critical events for the excision and ethylene regulation of adventitious root formation.

x CHAPTER I

INTRODUCTION

The architecture of roots is defined by a primary root and secondary or lateral

roots, which develop as branches off the primary roots. In addition, adventitious roots are

aerial borne roots formed post embryonically from shoot tissues of some plants. These

aerial roots serve numerous functions in plants including nutrient and water uptake,

providing mechanical support, and in vegetative propagation. Because these roots can

perform all the functions of primary and secondary roots, induction of adventitious roots

have been used agriculturally to propagate commercially important species from stem

cuttings (reviewed in De-Klerk et al., 1999). This technique allows clonal multiplication

of ideal varieties and propagation of species that have poor seed set or germination.

Though adventitious root formation is widely used in agriculture, the development of

these roots, the mechanism that drive development, and the signals that control this

process are much more poorly understood than for primary and lateral root development.

Environmental factors regulate adventitious root formation

Many environmental factors dictate the root architecture of plants (Furuya and

Torrey, 1964; Lovin, 2009). The majority of the published experiments on adventitious root formation focus on the effects of environmental factors. Growth of plants in red light produced the maximum number of adventitious roots in beans and birch, and yellow light induces adventitious roots in cherry, while blue light inhibits the formation in all species

(Fletcher et al., 1965; Pinker et al., 1989; Fuernkranz et al., 1990). Light quantity is also an important factor, as there is a reduction in adventitious roots formation in maize under

1 shaded conditions, with plants having altered root/shoot biomass allocation (Hebert et al.,

2001). In Arabidopsis, the light hypersensitive argonaute 1 (ago1) mutant had reduced

adventitious root formation (Sorin et al., 2005). Moreover, a species-specific effect of day

and night temperature on development of adventitious root formation was observed in

Eucalyptus, with temperatures lower than 15o C and higher than 40oC inhibiting

adventitious root development (Correa and Fett-Neto, 2004). Situations of stress in the

environment, such as wounding and flooding, also induces the formation of adventitious

roots in many plants, perhaps as an adaptive strategy (Mergemann and Sauter, 2000;

Visser et al., 1996).

Root development is extremely sensitive to available nutrients. Effects of nitrates, phosphates, and sulphates on lateral root formation and elongation have been well

documented (reviewed in Lopez-Bucio et al., 2003; Walch-Liu et al., 2006), while fewer

reports have examined nutrient effects on adventitious root development. When apple stem cuttings were treated with suboptimal levels of rooting media, sucrose was found to enhanced the formation of adventitious roots (Calamar and de Klerk, 2002). Elevated sucrose concentrations also enhance the formation of adventitious roots in rose stems, with higher sucrose to nitrogen ratios leading to the greatest induction (Hyndman et al.,

1981). Furthermore, adventitious root number and length in Eucalyptus were found to be affected by mineral nutrient concentrations, with some nutrients including zinc and calcium, had a positive effect, while other nutrients, such as iron and manganese, had a negative effect (Schwambach et al., 2005). Phosphorus deficiency reduces adventitious root elongation, but not the number of roots that formed (Schwambach et al., 2005).

Moreover, some of the effects of mineral nutrients were specific to the stage of

2 development of adventitious roots (Schwambach et al., 2005). In addition to external

factors, age and ecotype of plants also affected adventitious root formation in pine and

Arabidopsis (Diaz-Sala et al., 1996; King and Stimart, 1998). These results indicate that adventitious root formation involves a complex interaction of external factors.

Development of adventitious roots

Root development follows a precise developmental program, although the

initiation of this process is plastic. The development of lateral roots along primary roots

begins when pericycle cells become activated to undergo a precise series of cell divisions

to form root primordia which then differentiate into emerged lateral roots (Malamy and

Benfey, 1997). In cereals, lateral roots can also emerge from the endodermal layer of

roots (reviewed in Peret et al., 2009). Similar to lateral roots, adventitious roots originate from pericycle cells of the hypocotyl which progress through similar stages of division and development as lateral root primordia (Falasca and Altamura, 2003; Chapter 2). In addition, adventitious roots can develop from alternate tissues under certain conditions.

When treated with exogenous auxin, cells of the root endodermis and cortex were found

to contribute to the formation of adventitious roots, with longer treatments resulting in

adventitious root development from (Falasca and Altamura, 2003). In some woody species such as apple, adventitious roots emerge from cambium cells (as reviewed in De-

Klerk et al., 1999) while, under in vitro culture conditions, Arabidopsis thin cell layer (TCL), consisting of epidermis and cortex, can produce adventitious roots when treated with IBA ( 3-butyric acid) (Falasca et al., 2004). These reports indicate that adventitious root formation is complex in its development and that a number of factors

3 may regulate their formation, yet generally adventitious roots share developmental origin

and progression of growth in common with lateral roots.

Auxin transport, synthesis, and signaling regulates lateral root development

Auxin synthesis, signaling and transport are the key components involved in the regulation of root development (reviewed in Peret et al., 2009). Synthesis of auxin involves two pathways with dependent and tryptophan independent pathway

(reviewed in Woodward and Bartel, 2005). Auxin can be inactivated thorough conjugation and oxidation (reviewed in Woodward and Bartel, 2005). Mutant analysis have identified some of the enzymes and components of these pathways, yet our understanding of this complex pathway is still limited (Strader and Bartel, 2008).

Increased auxin concentration through exogenous application or genetic manipulations has been shown to result in enhanced lateral root formation (reviewed in Malamy, 2005).

In addition, the Arabidopsis mutants, superroot and rooty, which have high endogenous levels of IAA, exhibit a proliferation of lateral and adventitious roots (Boerjan et al.,

1995; Celenza et al., 1995).

Auxin is synthesized in the shoot apex and young and then transported towards the root shoot junction uni-directionally through the stem (Sieberer and Leyser,

2006). In the roots, auxin moves in two directions in two distinct tissues. Basipetal movement occurs from the root tip in epidermal and cortical cells, while acropetal transport occurs from the root shoot junction towards the root in cells of the central cylinder (reviewed in Muday and DeLong, 2001). Cell to cell movement of IAA is mediated by transport proteins located in the plasma membrane. These IAA transport

4 proteins include influx carriers such as AUX1 (AUXIN RESISTANT 1) and LAX (LIKE

AUX) (Bennett et al., 1996; Swarup et al., 2008), and efflux carriers such as members of

the PIN (PIN FORMED) and ABCB/MDR/PGP (ATP BINDING CASSETTE

B/MULTIDRUG RESISTANCE/P-GLYCOPROTEIN) protein families (Galweiler et al.,

1998; Noh et al., 2001; Teale et al., 2006; Zazimalova et al., 2010). The asymmetric

localization of PIN proteins have been suggested to play a critical role in defining the

polarity of IAA transport (reviewed in Muday and DeLong, 2001). Plants with mutations

in the genes encoding these proteins were utilized to explore the roles of specific auxin

transport proteins in adventitious root formation, as described in Chapter 2.

Auxin transport is also required for initiation and elongation of lateral roots as

judged by chemical, physical and genetic methods to block auxin flow (Reed et al., 1998;

Casimiro et al., 2001). Defects in AUX1, LAX , PIN1, and ABCB19/PGP19/MDR1

reduce initiation and/or elongation of lateral roots due to reduced movement of auxin

(Marchant et al., 2002; Swarup et al., 2008; Wu et al., 2007; Benkova et al., 2003).

Lateral root development has been shown to require complex changes in expression of

PIN proteins in developing primordia (Sauer et al., 2006; Benkova et al., 2003).

Examination of PIN3- and PIN7-GFP fusions in roots bent to initiate lateral roots has

revealed that the expression of these proteins is reduced in the roots below the point of

the bend, while AUX1-YFP is increased at the point of root formation, creating auxin

maxima that drives primordia formation (Laskowski et al., 2008). These results suggest

that regulation of carrier protein-mediated auxin transport plays an important role in

lateral root development.

5 Auxin signaling begins with the binding of auxin to the TIR1 (TRANSPORT

INHIBITOR RESPONSE 1) receptor. TIR1 is an F-box protein, part of ligase

E3 complex (reviewed in Parry et al., 2009). Binding of auxin to the receptor complex promotes its interaction with AUX/IAA proteins, which are repressors of auxin signaling, and targets them to be degraded by the 26S (Kepinski and Leyser, 2002).

This results in the release of auxin response factors (ARFs), transcription factors that then lead to auxin induced (reviewed in Leyser, 1998). In Arabidopsis, there are 22 known ARF proteins and 29 AUX/IAA proteins (Remington et al., 2004). The model for the function of these transcriptional regulation is that sets of these proteins interact to lead to tissue and developmental patterns of gene expression (Weijers et al.,

2005; Santner and Estelle, 2010).

The roles of several of the ARF and AUX/IAA in regulating development in

Arabidopsis have been examined through mutant analysis, though overlapping expression and function of these proteins make it difficult to deduce the complex pattern of interaction and functions of these proteins (reviewed in Reed, 2001). Several studies have identified the roles of genes encoding auxin signaling proteins that reduce lateral root formation including the auxin receptor, (TIR1), auxin response factors (ARF), and auxin induced genes (IAA/AUX) (reviewed in Casimiro et al., 2003). These mutants were utilized to understand auxin signaling required for adventitious root formation as described in Chapter 2. As auxin transport, signaling, and synthesis are important for root development, understanding these complex phenomena helps in dissecting the mechanisms of root development.

6 Positional specificity of lateral root formation

Despite all the studies examining the progression of development of root lateral

organs, the signals that define the longitudinal position along roots or hypocotyls from

which roots originate are still unknown. Auxin not only regulates the development of

roots but some studies have suggested a role for auxin in regulating the position of formation of lateral roots (Dubrovsky et al., 2008). When an auxin biosynthetic enzyme

was randomly activated through Cre/Lox system that lead to localized auxin synthesis,

the pattern of position of formation of lateral roots was altered (Dubrovsky et al., 2008).

Primary roots wave when grown on hard agar medium at an angle, with lateral roots

emerging from convex sides of the waves (De Smet et al., 2007). This formation was

altered in auxin transport defective mutant aux1 (De Smet et al., 2007). Additionally,

fluctuation of auxin accumulation was found to modulate the spacing of development of lateral roots (De Smet et al., 2007). Altered expression of the auxin signaling proteins

IAA12 and ARF5, was shown to mislocalize lateral roots (De Smet et al., 2010). The triple mutant pin2pin3pin7 which is defective in auxin transport proteins not only has increased lateral root density but at times these lateral roots emerged fused together

(Laskowski et al., 2008). In roots bent to initiate lateral roots, the expression of PIN3 and

PIN7 proteins reduce while expression of AUX1 increases, creating an auxin maximum that drives primordia formation (Laskowski et al., 2008). These results suggest that auxin transport, synthesis and signaling are involved in defining the position, and the formation of, the lateral roots.

7 Ethylene signaling and synthesis regulates root development

In addition to auxin, another major plant involved in regulation of root development is ethylene. The ethylene signaling pathway is mediated by a receptor family that includes ETR1 (ETHYLENE RESISTANT 1) (reviewed in Kieber, 1997).

Binding of ethylene to these receptors inactivates CTR1 (CONSTITUTIVE TRIPLE

RESPONSE 1), which encodes a kinase that is implicated in a MAPKKK cascade

(reviewed in Bleecker and Kende, 2000). Both receptors and CTR1 negatively regulate this pathway (Kieber, 1997). Downstream of CTR1 is EIN2 (ETHYLENE

INSENSITIVE 2), a Nramp metal ion transporter, which is required for ethylene signaling (reviewed in Bleecker and Kende, 2000). EIN3 (ETHYLENE INSENSITVE 3) and EILs (EIN3 LIKE) are transcription factors that regulate the expression of ethylene induced genes (reviewed in Bleecker and Kende, 2000). Ethylene biosynthesis begins with formation of ACC (Aminocyclopropane-1-carboxylic acid) by the enzyme ACC synthase (ACS), which is then converted to ethylene by the enzyme, ACC oxidase

(Argueso et al., 2007). ACS is modulated by ETO (ETHYLENE OVERPRODUCER), which regulates its protein stability (Chae et al., 2003). Plants with mutations in ethylene signaling or synthesis genes have provided valuable insights into the physiological proceses mediated by ethylene.

In Arabidopsis, etr1 and ein2 have enhanced lateral root formation, while eto1 and ctr1 have reduced formation of lateral roots (Negi et al., 2008). Similarly, the tomato

NR (Never ripe) mutant, which has a defect in a gene encoding an ethylene receptor, exhibits enhanced formation of lateral roots (Negi et al., 2010). Auxin and ethylene were shown to oppositely modulate lateral root development (Negi et al., 2008; Ivanchenko et

8 al., 2008). Furthermore, ethylene enhances auxin transport, while it inhibits the formation

of lateral roots in Arabidopsis and tomato (Negi et al., 2010; Negi et al., 2008). The

ethylene effect on lateral root formation is lost in auxin transport mutants, suggesting that the effect acts through these auxin transport proteins (Negi et al., 2008). These results indicate that ethylene is an important regulator of plant growth and development and that several of these physiological processes require complex interaction of auxin and ethylene.

Treatment with exogenous hormones alters adventitious root formation

The role of plant hormones in adventitious root formation has been examined in

numerous studies with a range of species, doses, growth, and treatment conditions

(reviewed in Li et al., 2009). Because of these variables, the effects of different hormones

from these reports are in many cases contradictory, as summarized in Table I-I. The two

hormones for which the data are the most clear are auxin and ethylene. In most species,

ethylene has a positive effect on adventitious root formation (Roy et al., 1972; reviewed

in De-Klerk et al., 1999; Clark et al., 1999; Negi et al., 2010), but in few cases ethylene

has been shown to inhibit (Coleman et al., 1980; Nordstrom and Eliasson, 1984) or have no effect (Batten and Mullins, 1978) on adventitious roots formation. Genetic tools are

now available to study this process in at least two species, Arabidopsis and tomato.

Chapters 3 and 4 of this thesis focus on examining the regulation of this process by ethylene.

Many internal and external pathways of regulation culminate at one central point to regulate physiological process. For adventitious root formation, this underlying signal

9

Table I-I: Effect of application of different hormones on adventitious root formation.

Hormone Effect Species Reference

Abscisic acid Positive Beans Tari and Nagy, 1996

Tomato Basu et al., 1970

Abscisic acid Negative Rice Steffens et al., 2006

Cytokinin No effect Arabidopsis Kuroha et al., 2006

Cytokinin Positive Centaurium erthraea Subotic et al., 2009

Cytokinin Negative Arabidopsis Pernisova et al., 2009

Gibberellic acid No effect Rice Steffens et al., 2006

Gibberellic acid Positive Peas Coleman and Greyson, 1977

Tomato Hansen, 1975

Brassinosteroids Positive Soybean Steffens et al., 2006

10 might be the auxin. Auxin has been commercially used to induce

adventitious root formation in stem cuttings of many species (reviewed in De-Klerk et al.,

1999). Most commonly, one of the natural forms of auxin, IBA (indole-3-byutric acid), is

used because of its greater stability than IAA (indole-3-acetic acid), even though IAA is

more abundant than IBA in plants. Several studies have compared the effects of IAA and

IBA in inducing adventitious roots and find that in most cases IBA induces adventitious

roots to a greater extent than IAA (Eliasson and Areblad, 1984; Riov and Yang, 1989).

This is not true in Arabidopsis, where IAA was found to induce a greater number of adventitious roots than IBA (Chapter 3).

Auxin is the central point of regulation of adventitious root formation by environmental factors such as temperature, light and nutrients as well as cross talk with

other hormones (Correa and Fett-Neto, 2004; Fletcher et al., 1965; reviewed in De-Klerk

et al., 1999). In contrast to other hormones, in most species auxin positively regulates

adventitious root formation (reviewed in De-Klerk et al., 1999; Chapter 2). To our

knowledge, one study has suggested a negative effect of one form of natural auxin;

indole-3-acetic acid (IAA) at lower concentrations (Eliasson and Areblad, 1984). This

suggests that auxin positively regulates adventitious root formation consistently across

species. The goal of the work described in chapter 2 of this thesis was to explore the

mechanisms by which auxin enhances adventitious root formation using the genetic tools available in Arabidopsis.

11 Positional specificity of adventitious root formation

Very few studies have looked at mechanisms that define the longitudinal position

of adventitious root formation. Excision-enhanced adventitious roots seem to develop at

1-2 mm above the site of excision, which coincides with positions of auxin accumulation

in hypocotyls of Arabidopsis (Chapter 2). Additionally, treatment with the protein

phosphatase inhibitor, canthardin, results in reduced auxin transport and delocalization of

adventitious root formation along the hypocotyls (Chapter 2). These results indicate that

auxin transport and local gradients might be involved in determining the position of

adventitious root formation, similar to formation of lateral roots.

Auxin-ethylene cross talk in adventitious root formation

Auxin-ethylene crosstalk has shown to be important in modulating diverse

physiological processes, including root growth and lateral root development (Ruzicka et

al., 2007; Stepanova et al., 2007; Negi et al., 2008). This mechanism for cross talk has

been explored by some studies, which found an interdependency of auxin and ethylene in

synthesis, movement, and signaling of both hormones. Auxin treatments in stems of

Rumex palustris under flooded conditions, and mung-bean, have been found to enhance the production of the ethylene precursor, ACC (1-aminocyclopropane-1-carboxylic acid),

and ethylene, respectively, resulting in induction of adventitious roots (Riov and Yang,

1989; Visser et al., 1996). But in peas, in which ethylene inhibits adventitious roots, low

dose of IAA were found to enhance ethylene production, resulting in inhibition of

adventitious roots, which were rescued by application of high doses of auxin (Nordstrom

and Eliasson, 1984). Conversely, ethylene has been shown to induce auxin synthesis in

12 root tips of primary roots (Ruzicka et al., 2007; Stepanova et al., 2007). Additionally,

ethylene-enhanced auxin sensitivity has been shown to increase adventitious root formation in Rumex palustris under flooded conditions (Visser et al., 1996). Consistent with this, the response of ethylene-insensitive mutants to auxin treatments is altered in tomato and Arabidopsis (Chapter 4; Clark et al., 1999). These results suggest cross talk between auxin and ethylene occurs at multiple levels in a species specific manner.

Use of genetics to study adventitious root formation

Genetic approaches to understand the mechanism of auxin-ethylene cross talk is a

valuable tool to understand the physiology and mechanisms driving adventitious root

formation. Altered expression of auxin response factor and auxin transport proteins were

found to reduce formation of adventitious roots in rice (Liu et al., 2005; Xu et al., 2005;

Liu et al., 2009). In Arabidopsis, mutants defective in initiation, development, and

elongation of adventitious roots have been isolated that are temperature sensitive, a few

of which had defective auxin signaling (Konishi and Sugiyama, 2003). In tomato, the

Never Ripe (NR) mutant has been shown to have reduced sensitivity to auxin-induced

adventitious root formation (Clark et al., 1999). Though some studies have revealed a

cross talk of auxin and ethylene using mutants, the mechanism of regulation at the level

of signaling, synthesis, and transport are still unknown.

This thesis utilized mutants and transgenic lines available in Arabidopsis to

analyze the components of auxin signaling, synthesis, and transport required for

adventitious root formation, as detailed in chapter 2. Additionally, these experiments

explored possible cross talk between auxin and ethylene at the level of signaling,

13 synthesis, and transport during adventitious root formation in both Arabidopsis and tomato as detailed in chapters 3 and 4, respecitvely. The results suggest that auxin transport and local auxin accumulation drives adventitious root formation in Arabidopsis.

Ethylene negatively affects both these processes, but has opposite physiological effects in

Arabidopsis and tomato, reducing the formation of adventitious roots in Arabidopsis and enhancing the formation in tomato. The results from this thesis provide insight into the components of auxin and ethylene signals which regulate adventitious root formation.

14 Literature cited

Argueso CT, Hansen M, Kieber JJ (2007) Regulation of ethylene biosynthesis. Journal

of Plant Growth Regulation 26: 92-105

Basu R, Roy B, Bose T (1970) Interaction of abscisic acid and in rooting of

cuttings. Plant and Cell Physiology 11: 681-684

Batten DJ, Mullins MG (1978) Ethylene and adventitious root formation in hypocotyl

segments of etiolated Mung-bean (Vigna radiata (L.) Wilczek) seedlings. Planta

138: 193-197

Benkova E, Michniewicz M, Sauer M, Teichmann T, Seifertova D, Jurgens G, Friml

J (2003) Local, efflux-dependent auxin gradients as a common module for plant

formation. Cell 115: 591-602

Bennett MJ, Marchant A, Green HG, May ST, Ward SP, Millner PA, Walker AR,

Schulz B, Feldmann KA (1996) Arabidopsis AUX1 gene: A permease-like

regulator of root . Science 273: 948-950

Bleecker AB, Kende H (2000) Ethylene: A gaseous signal molecule in plants. Annual

Review of Cell and Developmental Biology 16: 1-+

Boerjan W, Cervera M-T, Delarue M, Beeckman T, Dewitte W, Bellini C, Caboche

M, van Onckelen H, Van Montagu M, Inze D (1995) Superroot, a recessive

mutation in Arabidopsis, confers auxin overproduction. Plant Cell 7: 1405-1419

Calamar A, de Klerk GJ (2002) Effect of sucrose on adventitious root regeneration in

apple. Plant Cell Tissue and Organ Culture 70: 207-212

15 Casimiro I, Beeckman T, Graham N, Bhalerao R, Zhang HM, Casero P, Sandberg

G, Bennett MJ (2003) Dissecting Arabidopsis lateral root development. Trends

in Plant Science 8: 165-171

Casimiro I, Marchant A, Bhalerao RP, Beeckman T, Dhooge S, Swarup R, Graham

N, Inze D, Sandberg G, Casero PJ, Bennett M (2001) Auxin transport promotes

Arabidopsis lateral root initiation. Plant Cell 13: 843-852

Celenza JL, Grisafi PL, Fink GR (1995) A Pathway for Lateral Root-Formation in

Arabidopsis-Thaliana. Genes & Development 9: 2131-2142

Chae HS, Faure F, Kieber JJ (2003) The eto1, eto2, and eto3 mutations and cytokinin

treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability

of ACS protein. Plant Cell 15: 545-559

Clark DG, Gubrium EK, Barrett JE, Nell TA, Klee HJ (1999) Root formation in

ethylene-insensitive plants. Plant Physiol 121: 53-60

Coleman W, Greyson R (1977) Promotion of root initiation by Gibberellic acid in

discs of tomato (Lycopersicon esculentum) culutred in vitro. New Phytologist 78:

47-54

Coleman W, Huxter T, Reid D, Thrope T (1980) Ethylene as an endogenous inhibitor

of root regeneration in tomato leaf disc cultures in vitro. Physiol Plant 48: 519-

525

Correa L, Fett-Neto A (2004) Effect of temperature on adventitious root development in

microcuttings of Eucalyptus Saligna Smith and Eucalyptus globulus Labill.

Journal of Thermal biology 29: 315-324

16 De-Klerk G, Krieken W, DeJong J (1999) The formation of adventitious roots: New

concepts, new possibilities. In Vitro Cell Dev Biol-Plant 35: 189-199

De Smet I, Lau S, Voss U, Vanneste S, Benjamins R, Rademacher EH, Schlereth A,

De Rybel B, Vassileva V, Grunewald W, Naudts M, Levesque MP,

Ehrismann JS, Inze D, Luschnig C, Benfey PN, Weijers D, Van Montagu

MCE, Bennett MJ, Jurgens G, Beeckman T (2010) Bimodular auxin response

controls in Arabidopsis. Proceedings of the National Academy of

Sciences of the United States of America 107: 2705-2710

De Smet I, Tetsumura T, De Rybel B, Frey NFD, Laplaze L, Casimiro I, Swarup R,

Naudts M, Vanneste S, Audenaert D, Inze D, Bennett MJ, Beeckman T

(2007) Auxin-dependent regulation of lateral root positioning in the basal

of Arabidopsis. Development 134: 681-690

Diaz-Sala C, Hutchison KW, Goldfarb B, Greenwood MS (1996) Maturation-related

loss in rooting competence by loblolly pine stem : the role of auxin

transport, and tissue sensitivity. Physiol Plant 97: 481-490

Dubrovsky JG, Sauer M, Napsucialy-Mendivil S, Ivanchenko MG, Friml J,

Shishkova S, Celenza J, Benkova E (2008) Auxin acts as a local morphogenetic

trigger to specify lateral root founder cells. Proc Natl Acad Sci U S A 105: 8790-

8794

Eliasson L, Areblad K (1984) Auxin effects on rooting in pea cuttings. Physiol Plant 61:

293-297

Falasca G, Altamura M (2003) Histological analysis of adventitious rooting in

Arabidopsis thaliana (L.) Heynh seedlings. Plant Biosystems 137: 265-274

17 Falasca G, Zaghi D, Possenti M, Altamura MM (2004) Adventitious root formation in

Arabidopsis thaliana thin cell layers. Plant Cell Rep 23: 17-25

Fletcher R, Peterson R, Zalik S (1965) Effect of Light Quality on Elongation,

Adventitious Root Production and the Relation of Cell Number and Cell Size to

Bean Seedling Elongation Plant Physiol 40: 541-548

Fuernkranz H, Nowak C, Maynard C (1990) Light effects on in vitro adventitious root

formation in axillary shoots of mature Prunus serotina. Physiol Plant 80: 337-341

Furuya M, Torrey J (1964) The reversible inhibition by red far-red light of auxin

induced lateral root initiation in isolated pea roots. Plant Physiol 39: 987-991

Galweiler L, Guan CH, Muller A, Wisman E, Mendgen K, Yephremov A, Palme K

(1998) Regulation of by AtPIN1 in Arabidopsis vascular

tissue. Science 282: 2226-2230

Hansen J (1975) Light dependent promotion and inhibition of adventitious root

formation by gibberellic acid. Planta 123: 203-205

Hebert Y, Guingo E, Loudet O (2001) The response of root/shoot partitioning and root

morphology to light reduction in maize genotypes. Crop Science 41: 363-371

Hyndman S, Hasegawa P, Bressan R (1981) The role of sucrose and nitrogen in

adventitious root formation on cultured rose shoots Plant Cell, Tissue and Organ

Culture 1: 229-238

Ivanchenko MG, Muday GK, Dubrovsky JG (2008) Ethylene-auxin interactions

regulate lateral root initiation and emergence in Arabidopsis thaliana. Plant J 55:

335-347

18 Kepinski S, Leyser O (2002) Ubiquitination and auxin signaling: A degrading story.

Plant Cell 14: S81-S95

Kieber JJ (1997) The ethylene signal transduction pathway in Arabidopsis. Journal of

Experimental 48: 211-218

King JJ, Stimart DP (1998) Genetic analysis of variation for auxin-induced adventitious

root formation among eighteen ecotypes of Arabidopsis thaliana L. Heynh. J

Hered 89: 481-487

Konishi M, Sugiyama M (2003) Genetic analysis of adventitious root formation with a

novel series of temperature-sensitive mutants of Arabidopsis thaliana.

Development 130: 5637-5647

Kuroha T, Ueguchi C, Sakakibara H, Satoh S (2006) Cytokinin receptors are required

for normal development of auxin-transporting vascular tissues in the hypocotyl

but not in adventitious roots. Plant and Cell Physiology 47: 234-243

Laskowski M, Grieneisen VA, Hofhuis H, Hove CA, Hogeweg P, Maree AF, Scheres

B (2008) Root system architecture from coupling cell shape to auxin transport.

PLoS Biol 6: e307

Leyser O (1998) Auxin signalling: Protein stability as a versatile control target. Current

Biology 8: R305-R307

Li S, Xue L, Xu S, Feng H, An L (2009) Mediators, Genes and signaling in

Adventitious rooting. Bot.Rev 75: 230-247

Liu HJ, Wang SF, Yu XB, Yu J, He XW, Zhang SL, Shou HX, Wu P (2005) ARL1, a

LOB-domain protein required for adventitious root formation in rice. Plant

Journal 43: 47-56

19 Liu SP, Wang JR, Wang L, Wang XF, Xue YH, Wu P, Shou HX (2009) Adventitious

root formation in rice requires OsGNOM1 and is mediated by the OsPINs family.

Cell Research 19: 1110-1119

Lopez-Bucio J, Cruz-Ramirez A, Herrera-Estrella L (2003) The role of nutrient

availability in regulating root architecture. Current Opinion in Plant Biology 6:

280-287

Lovin M (2009) Exploring the role of auxin in phenotypic plasticity in arabidopsis

thaliana root development. Dissertation. Wake Forest University, Winston Salem

Malamy J (2005) Intrinsic and environmental response pathways that regulate root

system architecture. Plant Cell Environ 28: 67-77

Malamy J, Benfey P (1997) Organization and cell differentiation in lateral roots of

Arabidopsis thaliana. Development 124: 33-44

Marchant A, Bhalerao R, Casimiro I, Eklof J, Casero PJ, Bennett M, Sandberg G

(2002) AUX1 promotes lateral root formation by facilitating indole-3-acetic acid

distribution between sink and source tissues in the Arabidopsis seedling. Plant

Cell 14: 589-597

Mergemann H, Sauter M (2000) Ethylene induces epidermal cell death at the site of

adventitious root emergence in rice. 124: 609-614

Muday GK, DeLong A (2001) Polar auxin transport: controlling where and how much.

Trends in Plant Science 6: 535-542

Negi S, Ivanchenko MG, Muday GK (2008) Ethylene regulates lateral root formation

and auxin transport in Arabidopsis thaliana. Plant J 55: 175-187

20 Negi S, Sukumar P, Liu X, Cohen JD, Muday GK (2010) Genetic dissection of the

role of ethylene in regulating auxin-dependent lateral and adventitious root

formation in tomato. Plant J 61: 3-15

Noh B, Murphy AS, Spalding EP (2001) Multidrug resistance-like genes of

Arabidopsis required for auxin transport and auxin-mediated development. Plant

Cell 13: 2441-2454

Nordstrom A-C, Eliasson L (1984) Regulation of root formation by auxin-ethylene

interaction in pea stem cuttings. Physiol Plant 61: 298-302

Parry G, Calderon-Villalobos LI, Prigge M, Peret B, Dharmasiri S, Itoh H, Lechner

E, Gray WM, Bennett M, Estelle M (2009) Complex regulation of the

TIR1/AFB family of auxin receptors. Proceedings of the National Academy of

Sciences of the United States of America 106: 22540-22545

Peret B, De Rybel B, Casimiro I, Benkova E, Swarup R, Laplaze L, Beeckman T,

Bennett MJ (2009) Arabidopsis lateral root development: an emerging story.

Trends in Plant Science 14: 399-408

Peret B, Larrieu A, Bennett M (2009) Lateral root emergence: a difficult birth. Journal

of Experimental Botany 60: 3637-3643

Pernisova M, Klima P, Horak J, Valkova M, Malbeck J, Soucek P, Reichman P,

Hoyerova K, Dubova J, Friml J, Zazimalova E, Hejatko J (2009)

modulate auxin-induced organogenesis in plants via regulation of the auxin efflux.

Proceedings of the National Academy of Sciences of the United States of America

106: 3609-3614

21 Pinker I, Zoglauer G, Goring H (1989) Influence of light on adventitious root

formation in birch shoot culturesin vitro Biologia Plantarum 31: 254-260

Reed JW (2001) Roles and activities of Aux/IAA proteins in Arabidopsis. Trends in

Plant Science 6: 420-425

Reed RC, Brady SR, Muday GK (1998) Inhibition of auxin movement from the shoot

into the root inhibits lateral root development in arabidopsis. Plant Physiology

118: 1369-1378

Remington DL, Vision TJ, Guilfoyle TJ, Reed JW (2004) Contrasting modes of

diversification in the Aux/IAA and ARF gene families. Plant Physiology 135:

1738-1752

Riov J, Yang S (1989) Ethylene and Auxin-ethylene interaction in adventiitous root

formation in Mung bean (Vigna radiata) cuttings. Journal of Plant Growth

Regulation 8: 131-141

Roy B, Basu R, Bose T (1972) Interaction of auxins with growth-retarding, -inhibiting

and ethylene-producing chemicals in rooting of cuttings. Plant Cell Physiol 13:

1123-1127

Ruzicka K, Ljung K, Vanneste S, Podhorska R, Beeckman T, Friml J, Benkova E

(2007) Ethylene regulates root growth through effects on auxin biosynthesis and

transport-dependent auxin distribution. Plant Cell 19: 2197-2212

Santner A, Estelle M (2010) The ubiquitin-proteasome system regulates plant hormone

signaling. Plant Journal 61: 1029-1040

22 Sauer M, Balla J, Luschnig C, Wisniewska J, Reinohl V, Friml J, Benkova E (2006)

Canalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of

PIN polarity. Genes & Development 20: 2902-2911

Schwambach J, Fadanelli C, Fett-Neto AG (2005) Mineral nutrition and adventitious

rooting in microcuttings of Eucalyptus globulus. Physiology 25: 487-494

Sieberer T, Leyser O (2006) Plant science - Auxin transport, but in which direction?

Science 312: 858-860

Sorin C, Bussell JD, Camus I, Ljung K, Kowalczyk M, Geiss G, McKhann H,

Garcion C, Vaucheret H, Sandberg G, Bellini C (2005) Auxin and light control

of adventitious rooting in Arabidopsis require ARGONAUTE1. Plant Cell 17:

1343-1359

Steffens B, Wang JX, Sauter M (2006) Interactions between ethylene, and

abscisic acid regulate emergence and growth rate of adventitious roots in

deepwater rice. Planta 223: 604-612

Stepanova AN, Yun J, Likhacheva AV, Alonso JM (2007) Multilevel interactions

between ethylene and auxin in Arabidopsis roots. Plant Cell 19: 2169-2185

Strader LC, Bartel B (2008) A new path to auxin. Nature Chemical Biology 4: 337-339

Subotic A, Jevremovic S, Grubisic D (2009) Influence of cytokinins on in vitro

morphogenesis in root cultures of Centaurium erythraea-Valuable medicinal plant.

Scientia Horticulturae 120: 386-390

Swarup K, Benkova E, Swarup R, Casimiro I, Peret B, Yang Y, Parry G, Nielsen E,

De Smet I, Vanneste S, Levesque MP, Carrier D, James N, Calvo V, Ljung K,

Kramer E, Roberts R, Graham N, Marillonnet S, Patel K, Jones JDG, Taylor

23 CG, Schachtman DP, May S, Sandberg G, Benfey P, Friml J, Kerr I,

Beeckman T, Laplaze L, Bennett MJ (2008) The auxin influx carrier LAX3

promotes lateral root emergence. Nature Cell Biology 10: 946-954

Swarup K, Benková E, Swarup R, Casimiro I, Péret B, Yang Y, Parry G, Nielsen E,

De Smet I, Vanneste S, Levesque MP, Carrier D, James N, Calvo V, Ljung K,

Kramer E, Roberts R, Graham N, Marillonnet S, Patel K, Jones JDG, Taylor

CG, Schachtman DP, May S, Sandberg G, Benfey P, Friml J, Kerr I,

Beeckman T, Laplaze L, Bennett MJ (2008) The auxin influx carrier LAX3

promotes lateral root emergence. Nature Cell Biology In Press

Tari I, Nagy M (1996) Abscisic acid and ethrel abolish the inhibition of adventitious

root formation of paclobutrazol-treated bean primary leaf cuttings. Biologia

Plantarum 38: 369-375

Teale WD, Paponov IA, Palme K (2006) Auxin in action: signalling, transport and the

control of plant growth and development. Nature Reviews Molecular Cell

Biology 7: 847-859

Visser E, Cohen JD, Barendse G, Blom C, Voesenek L (1996) An Ethylene-Mediated

Increase in Sensitivity to Auxin Induces Adventitious Root Formation in Flooded

Rumex palustris Sm. Plant Physiol 112: 1687-1692

Walch-Liu P, Ivanov II, Filleur S, Gan YB, Remans T, Forde BG (2006) Nitrogen

regulation of root branching. Annals of Botany 97: 875-881

Weijers D, Benkova E, Jager KE, Schlereth A, Hamann T, Kientz M, Wilmoth JC,

Reed JW, Jurgens G (2005) Developmental specificity of auxin response by

24 pairs of ARF and Aux/IAA transcriptional regulators. Embo Journal 24: 1874-

1885

Woodward AW, Bartel B (2005) Auxin: Regulation, action, and interaction. Annals of

Botany 95: 707-735

Wu G, Lewis DR, Spalding EP (2007) Mutations in Arabidopsis multidrug resistance-

like ABC transporters separate the roles of acropetal and basipetal auxin transport

in lateral root development. Plant Cell 19: 1826-1837

Xu M, Zhu L, Shou HX, Wu P (2005) A PIN1 family gene, OsPIN1, involved in auxin-

dependent adventitious root emergence and tillering in rice. Plant and Cell

Physiology 46: 1674-1681

Zazimalova E, Murphy AS, Yang H, Hoyerova K, Hosek P (2010) Auxin transporter-

Why so many? Cold Spring Harb Perspect in Biol 2: a001552

25 CHAPTER II

POLAR AUXIN TRANSPORT MEDIATED BY ABCB19 AND PIN1 REGULATES

ADVENTITIOUS ROOT FORMATION IN ARABIDOPSIS

Sukumar P., Muday G.K.

The following manuscript has been submitted for review in Plant Physiology. Sukumar P performed the experiments and prepared the manuscript, and Muday G.K. acted in an advisory and editorial capacity.

26 Abstract

Adventitious roots emerge from aerial plant tissues and although the induction of these roots is essential for clonal propagation of agriculturally important plant species, little is known about the mechanisms that control this type of root formation. We have utilized Arabidopsis thaliana and its widely available genetic and molecular tools to

dissect the molecular mechanisms by which auxin controls this process. We developed a system to induce adventitious root formation in Arabidopsis by manipulating growth

conditions and by excising roots from hypocotyls. We find that root excision is

accompanied by an increase in auxin transport and local changes in AtGH3:GUS reporter above the site of excision, correlating with auxin accumulation. These changes precede development of adventitious roots. Examination of auxin transport mutants revealed that abcb19 and pin1 mutants have reduced adventitious root formation. Quantification of relative transcript levels detected an increase in PIN1, but not ABCB19 transcripts upon excision. However, pABCB19::ABCB19:GFP levels were higher in excised hypocotyls compared to intact plants, suggesting post transcriptional regulation of ABCB19.

Additionally, the phosphatase inhibitor, canthardin, which has been previously shown to regulate auxin transport in roots, reduces auxin transport and fluorescence of the pABCB19::ABCB19:GFP. Canthardin also affects the location at which adventitious roots emerge, in a partially ABCB19 independent manner. Thus, a change in protein phosphorylation state of ABCB19 may be a mechanism by which excision- induced adventitious root development occurs. Together, these results suggest that polar auxin transport mediated by ABCB19 and PIN1 regulate adventitious root formation in

Arabidopsis.

27 Introduction

The root structure of plants includes a primary root from which lateral roots form,

and may often include adventitious roots that form from the hypocotyl. While primary

roots are formed during embryogenesis, lateral and adventitious roots are formed post

embryonically (Malamy and Benfey, 1997). Both types of root branches function to increase nutrient and water uptake and anchor plants in soil. Lateral roots emerge from pericycle cells of the primary root and undergo a precise series of developmental stages before they emerge through the primary root (Malamy and Benfey, 1997). The ability of stems to initiate adventitious root formation may depend on many environmental and physiological factors (reviewed in De-Klerk et al., 1999). Induction of adventitious roots

using excision of stem segments has been widely used in the field of agriculture

(reviewed in De-Klerk et al., 1999). This technique allows clonal propagation of ideal

varieties of various agriculturally-important crop species (reviewed in Li et al., 2009).

Use of auxins to increase the frequency of formation of adventitious roots is common

practice. Even though this technique of using stem cuttings has been used for many years

to propagate plants, the mechanism by which auxin induces adventitious root formation

after excision is unknown. While many studies have explored the development of lateral

roots (reviewed in Peret et al., 2009), few studies have utilized the genetic tools available

in Arabidopsis to examine the mechanisms that control adventitious root formation.

Auxin synthesis, transport, and signaling all positively regulate lateral root

formation (reviewed in Peret et al., 2009). Increased auxin concentration through exogenous application or genetic manipulations has been shown to result in enhanced lateral root formation (reviewed in Malamy, 2005). In addition, the Arabidopsis mutants,

28 superroot and rooty have endogenously high levels of IAA and a proliferation of lateral

and adventitious roots (Boerjan et al., 1995; Celenza et al., 1995). Defects in the genes encoding auxin signaling proteins reduce lateral root formation including the auxin receptor, TRANSPORT INHIBITOR RESPONSE 1 (TIR1), auxin response factors

(ARF), and auxin induced genes (IAA/AUX) (reviewed in Casimiro et al., 2003).

Moreover, auxin transport is required for initiation and elongation of lateral roots as

judged by chemical, physical and genetic methods to block auxin flow (Reed et al., 1998;

Casimiro et al., 2001). Auxin movement is mediated by influx proteins such as AUX1

(AUXIN RESISTANT 1) and LAX (Like AUX), which helps auxin enter cells (Marchant

et al., 1999; Swarup et al., 2008), and efflux proteins such as PIN and ABCB/MDR/PGP

proteins, which are required for auxin to exit from cells (Galweiler et al., 1998;Noh et al.,

2001; Teale et al., 2006). Defects in AUX1, LAX , PIN1 (PIN FORMED1), and

ABCB19/PGP19/MDR1 (ATP BINDING CASSETTE B 19/P-GLYCOPROTEIN

19/MULTIDRUG RESISTANT 1) reduce initiation and/or elongation of lateral roots due

to reduced movement of auxin (Marchant et al., 2002; Swarup et al., 2008; Wu et al.,

2007; Benkova et al., 2003). Additionally, lateral root development has been shown to

depend on complex changes in expression of PIN proteins in developing primordia

(Sauer et al., 2006; Benkova et al., 2003). Examination of PIN3- and PIN7-GFP fusions in roots bent to initiate lateral roots has revealed that the expression of PIN3 and PIN7

proteins is reduced in the roots below the point of the bend, while, AUX1-YFP is increased at the point of root formation, creating auxin maxima driving primordia formation (Laskowski et al., 2008). These results suggest that regulation of carrier protein-mediated auxin transport plays an important role in lateral root development.

29 Although the primary and lateral root phenotypes of auxin transport and signaling

mutants have been reported, the adventitious root and other hypocotyl phenotypes are not

well characterized. ABCB19 is expressed in cotyledons, shoot apical meristem and

vasculature of light grown seedlings, and it is expressed throughout the hypocotyl tissues

of dark grown seedlings (Blakeslee et al., 2007; Lewis et al., 2009). abcb19 mutants have

reduced basipetal hypocotyl transport and hyper-gravitropic stems (Noh et al., 2003),

while pin3 mutants show reduced hypocotyl gravitropism and (Friml et al.,

2002). The auxin efflux protein PIN1 is expressed in shoot apical meristem and vasculature of stem tissues (Galweiler et al., 1998;Blakeslee et al., 2007). Additionally, pin1 mutants have pinformed inflorescence stems, associated with reduced auxin transport in these tissue (Okada et al., 1991). Changes in PIN protein localization have also been reported to be involved in apical hook opening (Zadnikova et al., 2010). More research is needed to understand the function of these proteins in other physiological processes in the hypocotyls.

Similar to lateral roots, auxin is an endogenous factor thought to regulate adventitious root formation. Yet, few studies have explored the importance of auxin in modulating adventitious root formation in the model system Arabidopsis. The mutant superroot (sur) has defects in the auxin synthesis pathway and forms many adventitious roots at random positions along the stem (Boerjan et al., 1995), while the mutant argonaute (ago1) forms fewer adventitious roots than wild type (Sorin et al., 2005). The defect in ago1 was traced to over accumulation of an auxin response factor, ARF17, which negatively regulates auxin induced genes (Sorin et al., 2005). Additionally, protein profiles of ago1 and sur identified factors that are linked to auxin synthesis and supply as

30 candidates for regulation of adventitious root formation (Sorin et al., 2006). Transcription factors involved in auxin signaling, ARF6 and ARF8, were found to regulate positively adventitious root formation (Gutierrez et al., 2009). Studies characterizing seedlings of the gain of function mutant shy2/iaa3 (short hypocotyl 2) show decreased adventitious root formation (Tian and Reed, 1999), while axr3/iaa17 (auxin resistant 3) mutants show increased formation of adventitious roots (Leyser et al., 1996). Variation among different ecotypes of wild type Arabidopsis in adventitious root formation in response to auxin suggests that adventitious root formation is a highly plastic process regulated endogenous and environmental factors (King and Stimart, 1998). Taken together, these studies suggest an important role for auxin in the regulation of adventitious root formation.

A few genetic studies have examined the mechanisms by which auxin signaling and transport regulate adventitious root formation. One study isolated temperature sensitive mutants in Arabidopsis that are defective in initiation, development and elongation of adventitious roots, a few of which were caused by defective auxin signaling

(Konishi and Sugiyama, 2003). In rice, the adventitious root less (arl1) mutant results in reduction of the number of adventitious roots, due to a defect in an auxin response factor gene that acts as an auxin dependent (Liu et al., 2005). Consistent with auxin transport being important for development of adventitious root formation,

OsPIN1 RNAi lines in rice exhibited reduced adventitious root formation (Xu et al.,

2005). Additionally, mutations in the guanine nucleotide exchange factor for ADP- ribosylation factor (OsGNOM1) reduced the formation of adventitious roots in rice, possibly due to altered localization and targeting of PIN proteins (Liu et al., 2009). Even though the importance of auxin in inducing adventitious roots is well known, the

31 components of its signaling, synthesis, and transport involved in the regulation of

adventitious root development are largely unknown, beyond these isolated examples.

Our study utilized Arabidopsis hypocotyls as a model system to understand the

basic mechanisms driving adventitious root formation. Arabidopsis seedlings, when

grown under low light conditions, form elongated hypocotyls that can be induced to form

adventitious roots by excision. We have utilized a wide array of mutants and reporter

constructs available in Arabidopsis to identify underlying processes driving adventitious

root formation. Furthermore, we have examined the expression of auxin transport proteins to dissect the mechanisms driving this process and utilized inhibitor treatments to understand the possible involvement of protein phosphorylation during adventitious root formation. These results help uncover the underlying mechanism and developmental processes that control the formation of adventitious roots.

32 Results

Root excision from hypocotyls increases adventitious root formation

To examine adventitious root formation, Arabidopsis seedlings were grown under

low light intensity (3-5 µmol m–2 s–1) to induce hypocotyl elongation and then transferred

to high light conditions (85-100 µmol m–2 s–1) on the 5th day after sowing. The number of

adventitious roots formed as a function of time after transfer to high light is shown in

Figure II-1A. Intact hypocotyls form few adventitious roots with an average of less than

one per plant by the 8th day after transfer. The excision of the basal half of the shoot and

the root system (from here on referred to as root excised hypocotyls) induces a

significantly greater number of adventitious roots. Adventitious roots began to form in

root excised hypocotyls 3-4 days after excision and continued to increase in number for at

least 8 days. Adventitious roots formed at middle intact hypocotyls, as shown in Figure

II-1B. In contrast, adventitious roots formed after root excision reproducibly form at a

position 1-2 mm above the site of excision. Root excised hypocotyls were used as a

model to study the role of auxin in adventitious root formation, as they formed

substantially greater numbers of adventitious roots.

Adventitious roots emerge from the central tissues of the hypocotyl

Lateral roots emerge from the pericycle cells of root tissue. We asked whether adventitious roots emerge from similar tissue in the hypocotyl using DIC (Differential interference contrast) light microscopy images of primordia and emerged adventitious roots in cleared hypocotyls. Figure II-2A shows adventitious roots at a number of developmental stages that parallel the stages of lateral roots. The development of

33

Figure II-1: Removal of basal portion of hypocotyl and root increases adventitious root

formation in Arabidopsis.

(A) The number of adventitious roots was determined in the intact hypocotyl or

hypocotyls excised at 0.5-0.75 cm from the apex. The average and SE of 20-30 seedlings

are reported.

(B) Adventitious root formation on intact (left) and excised (right) cleared hypocotyls is shown after 7 days. Arrow points to adventitious root in the intact hypocotyl, and arrow head points to site of excision. Scale bar is 5 mm.

34

A

B

C

Figure II-2: Adventitious roots emerge from pericycle tissues of the hypocotyl.

(A)& (B) DIC images of various stages of primordia development in cleared hypocotyl.

(C) Images of pericycle marker J0121::GFP with emerged adventitious roots taken using confocal laser scanning microscope using channel setting. Scale bar is 50 µm.

35 adventitious roots close to the vascular tissue is evident in Figure 2B. Additionally, we

used the enhancer trap line J0121, which expresses GFP in pericycle cells of the hypocotyl and root (Laplaze et al., 2005), to understand the tissue origin of adventitious roots. J0121 seedlings were grown under the above mentioned conditions and were excised to induce adventitious root formation. Images of emerging and elongating adventitious roots were taken using a confocal laser scanning microscope, using channel settings as shown in Figure II-2C. GFP fluorescence was observed in pericycle tissue, while the fluorescence seen in epidermal tissue is due to chlorophyll auto-fluorescence.

Thus, like lateral roots, adventitious roots develop from pericycle tissue in Arabidopsis and show similar developmental progression, as lateral roots. But, unlike lateral roots, in which other roots are inhibited near the site of root formation, adventitious roots seem to emerge very close and at times adjacent to each other as seen in Figure II-2A and II-2C.

These images suggest that adventitious and lateral roots arise from pericycle cells, and exhibit a similar development program but have unique regulatory mechanisms defining spatial patterning.

Mutants scr1 and shr1 have reduced adventitious root formation

scr (scarecrow) and shr (short root) mutants were isolated for their altered root and shoot radial organization phenotypes (Scheres et al., 1995; Fukaki et al., 1998). They are defective in transcriptional factors involved in tissue development and radial organization (DiLaurenzio et al., 1996). These mutants lack normal endodermis and cortical layers and were also identified in a separate screen for defective shoot gravitropic responses, tied to the absence of the starch statolyths containing cell layer in which

36 gravity is perceived and which basipetal and lateral auxin transport occurs (Fukaki et al.,

1998). Even though these mutants have a normal pericycle layer, lateral root formation is

reduced (data not shown). We asked if these mutants were defective in adventitious root

formation. The number of adventitious roots formed seven days after root excision was

quantified in scr-1 and shr-1, as reported in Figure II-3A. scr-1, but not shr1, forms

statistically significantly fewer adventitious roots than wild type. This result suggests a

role for the cortex of the hypocotyl either directly or indirectly affecting auxin distribution influencing adventitious root formation.

In addition, we examined the expression pattern of SCR during adventitious root

formation, using the transgenic line pSCR::GFP, as shown in Figure II-3B. pSCR::GFP expression was increased by 30% after excision in the endodermis tissue layer and also was found to be expressed in developing primordia. This suggests that, in addition to modulating radial tissue differentiation, SCR is expressed in tissue from which adventitious roots form, with enhanced expression associated with conditions in which there is an increase in root formation.

Auxin from the shoot apex is required for adventitious root formation

We asked if adventitious root formation is dependent on auxin transport in an analogous

manner to lateral root formation. Root excised hypocotyls were treated with 10 µM of the

IAA efflux inhibitor 1-N-naphthylphthalamic acid (NPA) added to the agar upon which

plants were grown, or their shoot apices were removed, to eliminate the source of auxin.

The number of adventitious roots formed in response to these treatments was quantified

on the 7th day after treatment, as shown in Table II-I. Both treatments prevented

37

A 7 6 5 4 ** 3 2 1

Number of adventitious roots 0 B WT scr1 shr1

Figure II-3: Effect of scr1 and shr1 mutations on adventitious root formation.

(A) Low light grown wild type and scr1 and shr1 mutant seedlings were excised at 5 days and the number of adventitious roots formed 7 days after excision was determined. The average and SE of 32-50 seedlings are given. * Indicates p≤ 0.05 between genotypes as

determined by Student’s t-test.

(B) pSCR::GFP expression were observed in excised hypocotyls using confocal laser

scanning microscope. Numbers on the bottom correspond to average GFP fluorescence

relative to intact hypocotyls. Scale bar is 50 µm.

38

Table II-I: Auxin from the shoot is important for adventitious root formation.

Shoot apex Treatment Number of

adventitious roots

Present None 5.8±0.4

Present 10µM NPAa 0±0c

Absent None 0±0c

Absent 100µM IAAb 4.8±0.4

Absent 100µM IAA+100µM NPAb 1.1±0.3c

Seedlings were grown for 5 days in low light with or without their shoot apex.

Values are average and SE from 18-20 seedlings. a. Seedlings were treated globally. b. Seedlings were treated locally with agar containing these compounds applied at

the shoot apex. c. Values are significantly different from control with, p<0.05, as determined by

Student’s t- test.

39 adventitious root formation, suggesting that polar transport of IAA derived from the

shoot apex and/or cotyledons is necessary for adventitious root formation.

To further confirm that apex-derived auxin is essential for adventitious root formation,

the shoot apex of root excised hypocotyls was removed and the resulting hypocotyl

segments, or explants, were given a localized IAA treatment as an agar line at the apical

end of the hypocotyl (Table II-I). Local application of exogenous IAA (100 µM) to the

apical end of upright hypocotyls was able to restore adventitious root formation in these

hypocotyls. Additionally, application of 100 µM NPA locally below the site of

application of IAA reduced the induction of adventitious roots, indicating that auxin

movement from the shoot apex is required for adventitious root formation.

Induction of adventitious roots by exogenous IAA is dose dependent

To test whether various levels of auxin regulate the degree of adventitious root

formation, we treated 5 day old excised and intact hypocotyls with a range of concentrations of IAA added to the agar medium upon which the seedlings were grown.

The number of adventitious roots formed under different treatments was quantified 7 days later and is reported in Figure II-4A. IAA treatment of intact hypocotyls and root

excised hypocotyls formed more adventitious roots than untreated hypocotyls at

concentrations ranging from 0.1µM to 25µM IAA, suggesting that IAA positively

regulates this process. The magnitude of induction of root formation by IAA was 1.6-fold

in root excised hypocotyl and was greater in intact hypocotyls (13.5- fold) as there are

fewer roots in untreated controls. With a global application of 100µM, there was

inhibition of root formation (data not shown), as opposed to the local application of this

40

Figure II-4: The effect of IAA on adventitious root formation.

41 (A) The number of adventitious roots formed in control or seedlings treated with a range of concentration of IAA. The average and SE for 10-31 seedlings are reported.

(B) Images of cleared wild type hypocotyls; control and treated with 25 µM IAA, 7 days after root excision.

(C) Hypocotyls of AtGH3:GUS transgenic seedlings were stained 9, 18, 24 and 48 hrs after root excision. Arrow head points to field of view in insets.

(D) Root excised hypocotyls of AtCYCB1;1:GUS transgenic seedlings were stained after

9, 18, 24 and 48 hrs. Arrow heads point to positions of GUS expression.

Scale bars are 1 mm.

42 dose which stimulates adventitious root formation. The adventitious roots that emerged

from global IAA treatments were distributed all along the hypocotyls, as shown in Figure

II-4B. This result suggests that adventitious root formation is positively regulated by IAA

treatment and that hypocotyls are capable of forming adventitious roots in response to

auxin at multiple positions.

Local increases in auxin-induced GUS expression occur after excision at position of

adventitious root formation.

We hypothesized that the effect of excision is to increase local auxin signaling at

the base of the hypocotyl which then drives adventitious root formation. Root excised

hypocotyls of Arabidopsis plants transformed with an auxin responsive -GUS

fusion, AtGH3:GUS (Li et al., 1999), were excised every hour for 9 hrs and at 24 and 48

hrs, as shown in Figure II-4C. No expression was detected 1-8hrs after excision (data not

shown). The earliest time at which AtGH3:GUS expression was detected 9 hrs after

excision. The expression appeared above the point of excision. AtGH3:GUS was also

expressed in the apex of developing adventitious roots (data not shown).

Additionally, we examined the initiation of at similar time points

after excision in a reporter line with the cyclinB1 promoter driving GUS, which is only

expressed in actively dividing cells, AtCYCB1;1:GUS (DiDonato et al., 2004). We find that AtCYCB1;1:GUS expression is detected at 18hrs-24hrs (Figure II-4D), which is much later than AtGH3:GUS. When the time line of expression of GH3- and CYC- GUS expression are analyzed, the results suggest that local auxin induction precedes cell division.

43 As there are changes in auxin-induced gene expression after excision, we asked if

there were also changes in the level of free IAA with excision. 5 day old seedlings were

left intact or were root excised, and free IAA level was quantified in the entire hypocotyl

at 0 hrs, 24 hrs, and 48 hrs after root excision and compared to intact seedlings, as shown

in Supplemental Figure II-S1. The levels of free IAA in both intact and excised tissues

increased during the treatment period. There were slight, but not significant, increases in

free IAA levels with excision. Although we expected elevated free IAA after excision to

parallel the local AtGH3:GUS increases, it is likely that free IAA only changes locally, not in the entire hypocotyl used for these measurements of free IAA.

Adventitious root phenotype of auxin signaling mutants

Several auxin signaling mutants including tir1, axr1, axr4, iaa14, arf7, and arf19

have defective lateral root formation, indicating a role of auxin signaling during induction of cell differentiation and cell division in post embryonic organ development

(reviewed in Casimiro et al., 2003). We asked if adventitious root development is regulated by similar auxin signaling proteins in these mutants. The average number of adventitious roots in these mutants was compared to wild type, 7 days after root excision, as shown in Figure II-5A. The tir1 and axr1 mutants have defects in an auxin receptor complex, but we find that these mutants produce a similar number of adventitious roots to wild type. iaa3, iaa14, and iaa17 are defective in members of the AUX/IAA family of auxin induced genes (Fukaki et al., 2002, Leyser et al., 1996), and while iaa14 and iaa17 mutants form wild type numbers of adventitious root formations, iaa3 has reduced development of adventitious roots. A previous characterization of iaa17/axr3-3 mutant

44

S1 25 Intact 20 Excised 15

10

5

Free IAA levels ng/gFW levels IAA Free 0 0hrs 24hrs 48hrs

Supplemental Figure II-1: Free IAA levels were quantified in hypocotyls using IAA extraction followed by detection using GC-MS. Average and SE are given, but no significant differences between intact and excised samples were detected.

45

A C 160 300 * 140 * 250 120 Col 8 200 100 150 80 * 60 * 100 40

% of wild type 50 Relative basipetal 20 hypocotyl transport, % 0 0 Intact Excised Number of adventitious of roots, Number 7 tir1 19 WT axr1 iaa3 a14 a1 arf7 rf axr4 B ia ia a D arf7-arf19 140 500 120 * WT 400 35S:ABCB19 100 * * 80 * 300 * 60 * 200

% of wild type 40 100 20 to wild type, % relative 0 0 Number of adventitious roots, T 1 3 7 9 Effect ABCB19 of expression, over Number of Basipetal W in2 in 1 aux1 pin p pin p adventitious IAA abcb roots transport

Figure II-5: Auxin signaling and transport are required for adventitious root formation.

(A) The effect of mutations in genes encoding auxin signaling proteins was determined for 9-34 root excised seedlings with average and SE presented.

(B) The effect of mutations in genes encoding auxin transport proteins with average and

SE for 10-31 root excised seedlings are reported.

(C) Hypocotyl basipetal IAA transport was measured in intact and root excised seedlings and is normalized relative to intact seedlings. Average and SE of 18-20 seedlings are reported.

46 (D) The effect of 35S-ABCB19 on auxin transport and root excision was compared, 2 or

7 days after excision, respectively. Average and SE are given.

* Indicates p≤ 0.05 as determined by Student’s t-test, with comparisons in panel A, B, D, between indicated genotypes and wild type, and in panel C, intact and excised seedlings are compared.

47 had reported increased adventitious root formation relative to wild type (Leyser et al.,

1996), but we did not observe this increase under our growth conditions possibly because of differences in the way plants were grown. Auxin response factors (ARFs) are transcriptional regulators of auxin induced genes. We found that the arf7 mutant has increased adventitious root formation. Additionally, the arf7-arf19 double mutant has reduced adventitious root formation, even though the arf19 single mutant did not show a phenotype. The auxin resistant mutant, axr4, has defective root and shoot branching, defective leaf morphology and (Hobbie and Estelle, 1995). However, axr4-2 had slightly increased numbers of adventitious roots relative to wild type.

To understand whether the relative effects of these mutations is due to their expression pattern in hypocotyls, we examined previously published microarray data using the GEO database, as shown in Supplemental Figure II-S2 (Van Hoewyk et al.,

2008). All of the genes for which we examined mutant lines, except PIN2, were expressed in the hypocotyls, but there was variability in the level at which they were expressed. The absence of correlation between phenotypes and expression patterns in the signaling mutants is not surprising, due to the complex gene families encoding these proteins and redundant functions of family members. But for many of these signaling mutants, hypocotyl phenotypes have not been reported, suggesting that alternative signaling molecules may function in hypocotyl tissue and regulate adventitious root formation.

Excision increases auxin transport

We examined auxin transport in intact and root excised hypocotyls to see if there are

48

S2 2000

1500

1000 Abundance 500

0 1 7 4 1 3 7 A3 F R N N XR A R I TIR1A I AA17A AX AUX1 PIN PIN2 PI P IAA14I ARF19 ABCB19

Supplemental Figure II-2: Transcript abundance of IAA signaling and IAA transport genes from previously published microarray data (Van Hoewyk et al., 2008).

49 changes in auxin transport after root excision that might drive adventitious root

formation. Intact and root excised 5 day old, low light grown seedlings were transferred

to control plates, their cotyledons and shoot apices were removed, and radioactive IAA

was applied locally in an agar line at the apical end. Radioactive IAA transport in

hypocotyls after 3 hrs of application was quantified using a 3 mm section taken from the

basal end of root excised hypocotyls or sections at similar position in the hypocotyl of

intact plants. Figure II-5C compares the IAA transport in intact hypocotyls and hypocotyl

explants in wild type plants and shows that basipetal IAA transport increases 2.5- fold in

the hypocotyls after excision. This result is consistent with removal of the root portion of

the plant leading to increase in auxin flow, which might lead to local auxin accumulation,

driving adventitious root formation.

Mutants defective in IAA efflux carriers have reduced adventitious root formation

Because root excision increases auxin transport and thereby drives adventitious root formation, we asked which auxin transport proteins are involved in this process.

Auxin transport mutants aux1, pin3, pin7, and abcb19 have lateral root defects (Marchant et al., 2002; Laskowski et al., 2008; Wu et al., 2007). We tested whether AUX1, PIN1,

PIN2, PIN3, and ABCB19 mediated auxin transport are necessary for adventitious root formation. For this, low light grown wild type and aux1, eir1-1 (a pin2 allele), pin3-4, mdr1-1 (an abcb19 allele), pin7 and pin1-1 hypocotyls were root excised and their adventitious root formation was quantified 7 days after excision, as shown in Figure 5B.

As the abcb19 mutant is in the Ws background, pin1-1 in Ler, and all other mutants are in

Col, the result is reported relative to the appropriate wild type control. aux1-7 and pin2

50 showed no significant difference in adventitious root formation, while pin3-3, but not

pin3-4 (data not shown), showed slight but significant reduction. pin7 showed a

significant 20% reduction in adventitious root formation. In contrast, abcb19 and pin1-1 formed 50% fewer adventitious roots than wild type (p< 0.05). This suggests that adventitious root formation in hypocotyls depends strongly on ABCB19 and PIN1 regulated auxin transport.

Previously published microarray data shows that AUX1, ABCB19, and PIN3 are the transport proteins most highly expressed in hypocotyls (Van Hoewyk et al., 2008,

supplemental figure II-S2). Mutations in genes encoding two of these auxin transport

proteins, ABCB19 and PIN3, have adventitious root phenotypes, while AUX1 had no

phenotype. This is not surprising, when one considers that AUX1::YFP is expressed only

in the epidermal cells of hypocotyls, a tissue layer not tied to adventitious root development (data not shown). The low level expression of PIN1 is consistent with the

absence of a detected PIN1:GFP signal in this tissue, except at the shoot apex (Heisler et

al., 2005). This result suggests that the role of PIN1 in this process may be highly local,

rather than along the whole hypocotyl.

ABCB19 over-expression increases adventitious root formation

To confirm the role of ABCB19 in auxin transport required for adventitious root

formation, we quantified adventitious root numbers in an ABCB19 over-expression line,

35S-ABCB19 seedlings (Wu et al., 2007), as shown in Figure II-5D. Even without

excision, over expressing lines of 35S-ABCB19 formed approximately 3-fold more

adventitious roots than intact wild type. We examined basipetal auxin transport in intact

51 seedlings of wild type and 35S-ABCB19, as shown in Figure II-5D. It is has been

previously reported that hypocotyls of abcb19/mdr1 mutant have reduced basipetal auxin

transport (Noh et al., 2001). Consistent with the overexpression of an auxin transport

protein 35S-ABCB19 had a significant 3-fold greater transport than wild type. This

suggests that ABCB19 mediated auxin transport drives adventitious root formation.

pABCB19:ABCB19:GFP fluorescence increases after excision

PIN1 and ABCB19 are required for wild type levels of adventitious root formation and IAA transport is increased with root excision, suggesting that PIN1 and

ABCB19 expression may be increased by excision. 5 day old low light grown

pPIN1::PIN1:GFP, and pABCB19::ABCB19:GFP seedlings were transferred to high

light conditions with or without excision. Although the PIN1 transcripts were detected in

this tissue, PIN1:GFP signal was not detected in hypocotyl tissue (data not shown),

possibly due to a less intense GFP construct. Images of pABCB19::ABCB19:GFP intact

and excised hypocotyls were captured 48 hrs later using laser scanning confocal

microscopy, under identical settings as shown in Figure II-6A. GFP fluorescence was

quantified in images of intact and excised hypocotyls using line profile along the

longitudinal sides of cells in the Zeiss Zen software. In hypocotyls, root excised

pABCB19::ABCB19:GFP had enhanced signals compared with intact hypocotyls, as

shown in Figure II-6A and Table II- II. In 6 out of 9 experiments, average GFP intensity

of excised hypocotyls was significantly more than in intact controls. Among the

experiments that showed significant increase at 48 hrs, 83% of excised hypocotyls had

enhanced ABCB19:GFP fluorescence relative to intact hypocotyls (Table II-II).

52

A C

3.5 3.0 0 hrs 6 hrs 2.5 2.0 1.5 1.0 0.5

Relative transcript levels 0.0 ABCB19 PIN1 B D

Figure II-6: PIN1 transcription and pABCB19::ABCB19:GFP protein accumulation is enhanced with excision.

(A), (B) Confocal images of intact and root excised hypocotyls of pABCB19::ABCB19:GFP 48 hrs (A) or 6 hrs (B) after root excision. Images of intact and excised hypocotyls were taken with identical settings. Scale bars are A:50 µm, B: 200 µm.

(C) Fold changes in relative transcript levels of PIN1 and ABCB19 in hypocotyls, 6 hrs after root excision compared to levels in hypocotyls at the time of excision, determined using qRT-PCR.

53 (D) Confocal images of intact and root excised hypocotyls of pABCB19::GFP 6hrs after

root excision. Images of intact and excised hypocotyls were taken with identical confocal settings. Scale bar is 50 µm.

54

Table II-II: Root excision alters ABCB19:GFP fluorescence

GFP construct used Treatment Intensity relative to

control (%)

pABCB19::ABCB19:GFP Excision 160.6 ± 11.2a,c

pABCB19::GFP Excision 87.5 ± 3.7a

pABCB19::ABCB19:GFP Excision & 66.0 ± 4.3b,c

10µM Canthardin

Quantification of intensity performed using linear profile on the lateral sides of cells, with the values normalized relative to indicated control and are average and SE from 12-

21 seedlings. a. Controls are intact hypocotyls. b. Controls are untreated excised hypocotyls. c. Values are significantly different from controls with p<0.05, as determined by Students t test

55 This increase was observed as early as 6 hrs after excision (data not shown). This

suggests that pABCB19::ABCB19:GFP expression may be enhanced in excised

hypocotyls, consistent with the role of ABCB19 in regulating auxin transport necessary

for adventitious root formation.

Additionally, we asked if the changes in pABCB19::ABCB19:GFP observed were

local or global in relation to site of excision. Images of intact and excised hypocotyls

were captured 6 hrs after excision using the tile scan setting of the laser scanning

confocal microscope, which takes multiple pictures horizontally and vertically adjacent to

each other at a given magnification, as shown in Figure II-6B. We found that the increase

in pABCB19::ABCB19:GFP expression occurred throughout the hypocotyl and was not

localized to any particular site in relation to excision, suggesting that an overall change in

ABCB19 protein accumulation drives the increased auxin transport after excision.

Excision increases PIN1 but not ABCB19 transcription

To further test if there is increase in expression of PIN1 and ABCB19 after excision, we examined the relative transcript levels of PIN1 and ABCB19 after excision using qRT-PCR. Total RNA was extracted from root excised hypocotyls at the time of excision (control) or 6 hrs after excision. cDNA reactions were performed, followed by qRT-PCR, results of which are shown in Figure II-6C. There was a 2-fold increase in

PIN1 messages in excised hypocotyls, compared to control. Although this response was not statistically significant, this increase was found in four separate samples, due to variability in the magnitude of the PIN1 changes in response to treatments. These results

56 suggest that enhanced PIN1 synthesis plays a role in excision induced increase in auxin

transport and adventitious root formation.

Surprisingly, no differences were detected in relative expression of ABCB19, 6

hrs after excision in 3 separate experiments. To test if the changes in transcripts occurred

earlier or later than 6 hrs, other time points after excision were examined, but no

significant changes were detected after 2, 4, 9, 18, 24, or 48 hrs after excision (data not

shown). Since we did not observe significant changes in transcripts of ABCB19, pABCB19::GFP; a transcriptional fusion, was examined to ask how excision affected

ABCB19 expression. There was no change in intensity of fluorescence 6 hrs after

excision, compared to intact hypocotyls in 5 day old seedlings as shown in Figure II-6D

and Table II-II. Increases in ABCB19 as suggested by pABCB19::ABCB19:GFP

fluorescence changes after excision, together with consistent ABCB19 transcripts levels suggests a possible post transcriptional modification in ABCB19 protein which enhances its accumulation, controlling auxin flow needed for adventitious root formation.

Protein phosphatase activity regulates auxin transport and localization of adventitious

root emergence

We asked if protein phosphorylation could be involved in post translational

regulation of ABCB19 function. Wild type seedlings treated with 10µM canthardin, a

broad spectrum phosphatase inhibitor, were examined for adventitious root formation, as

shown in Figure II-7A. Surprisingly, in canthardin treated wild type hypocotyls,

adventitious roots emerged from locations distributed along the entire hypocotyl in

contrast to the localized formation in untreated seedlings, as shown in Figure II-7B. This

57

A

B D 120 WT Control 100 WT+Canth

80 * 60

40

20

0 Number of Basipetal Relative % of wild type wild % of Relative adventitious IAA C roots transport

Figure II-7: Phosphorylation regulates localization of adventitious roots.

58 (A) Wild type and abcb19 seedlings were treated with or without 10 µM canthardin for 7

days and the resulting cleared images are shown. Numbers at the bottom right corner indicate the % of seedlings with that particular phenotype. Scale bar is 1 mm.

(B) The number of adventitious roots formed at 7 days, or IAA basipetal transport at 48

hrs, after root excision, in control and seedlings treated with 10 µM canthardin are

presented relative to untreated controls. Average and SE are given. * Indicates significant differences with and without cantharidin treatment as determined by Student’s t-test with p<0.05.

(C) Confocal images of pABCB19::ABCB19:GFP seedlings treated with or without 10

µM canthardin, 6 hrs after root excision. Images of control and treated were taken at same settings. Scale bar is 50 µm.

(D) Root excised hypocotyls of AtGH3:GUS transgenic seedlings were treated with or without 10 µM canthardin, and were stained 72 hrs later. Scale bars are 1 mm.

59 phenotype was seen in 90% of canthardin treated wild type seedlings. Additionally, only

50% of abcb19 mutants showed this phenotype, suggesting that the abcb19 mutation

causes partial insensitivity to canthardin induced de-localization of adventitious root emergence. No changes were observed in the absolute number of adventitious roots formed in any of the treatments compared to wild type. These results point to the involvement of protein phosphorylation in defining the position of adventitious root emergence through modification of ABCB19 protein function.

To test if changes in localization of adventitious roots during cantharidin treatment are due to changes in auxin transport, hypocotyl basipetal transport was measured in wild type low light grown seedlings transferred to high light conditions for

48hrs and treated with canthardin, as shown in Figure II-7A. Canthardin treatment caused

a reduction in basipetal transport compared to wild type. Consistent with this, we saw a

reduction in pABCB19::ABCB19:GFP fluorescence 6 hrs after excision when treated

with canthardin, compared to untreated, as shown in Figure II-7C and Table II-II. This

suggests that protein dephosphorylation reduces auxin transport, which regulates the

position of adventitious root formation, and these changes might partially occur thorough

ABCB19.

To test if the changes in local auxin accumulation seen 9hrs after excision were

affected with canthardin treatment, we looked at AtGH3::GUS expression with and

without canthardin treatment as shown in Figure II-7D. At 72hrs after excision, untreated

seedlings show GH3::GUS expression above the site of excision, while no such

expression was seen in canthardin treated seedlings. The GUS expression seen in

canthardin treated hypocotyls was more diffused and closer to the shoot apex than control.

60 This suggests that the effects of canthardin on longitudinal auxin transport may prevent the formation of local auxin maxima at the base and lead to auxin distribution along the hypocotyl, thereby altering the position of adventitious root formation.

61 Discussion

Plants form two types of post-embryonic roots, lateral and adventitious roots,

which arise from two different tissues, but share substantial structural similarities.

Lateral roots form as branches along a primary root, while adventitious roots form from shoot or other aerial tissues. Both types of root structures serve important functions in plants providing an extensively branched network that absorbs moisture and nutrients and provides additional support to keep plants upright. Despite the apparent structural similarities between adventitious and lateral roots, much less is known about the mechanisms by which adventitious root development and initiation occur. The developmental sequence (Malamy and Benfey, 1997), environmental (reviewed in

Malamy, 2005), and hormonal controls (reviwed in Casimiro et al., 2003) of lateral root formation are well studied in Arabidopsis thaliana, yet the low frequency of adventitious root formation (with only 1 to 2 adventitious roots forming per plant) in Arabidopsis has limited the studies of this process (Gutierrez et al., 2009).

These experiments explored the developmental sequence and hormonal controls of adventitious root formation in Arabidopsis. We manipulated the growth of

Arabidopsis to maximize adventitious root formation through growth of seedlings under low light followed by excision of the lower half of the hypocotyl (termed root excision) and transfer to high light. Adventitious roots form with 10-fold higher frequency when the primary root and lower half of hypocotyls have been removed as compared to intact controls. This root excision also alters the position of adventitious root formation from a random localization along intact hypocotyls to a single position localized to 2-3 mm above the site of excision. This enhanced root formation after root excision facilitates

62 study of this process and is consistent with induced root formation by root excision used for vegetative propagation of horticultural plant species (reviewed in De-Klerk et al.,

1999). We have examined adventitious root development under our growth and induction conditions and found that like the well characterized process of lateral root formation, adventitious roots emerge from hypocotyl pericycle cells that are expressing the pericycle marker J0121. This finding is consistent with a previous study that used histological analysis and suggested adventitious roots initiate from pericycle cells (Falasca and

Altamura, 2003). We examined the development of primordia in multiple developmental stages using DIC light microscopy images and find that they follow a similar developmental progression as lateral roots. Unlike lateral roots, adventitious roots emerge close together with no apparent position-specific inhibition of primordia formation. We also examined the role of the SHR and SCR genes in this process, as these genes are involved in regulating radial patterning of both shoot and root tissue, and whose mutants have reduced lateral root formation (data not shown). The scr mutant, which has a defect in radial pattern in the root and hypocotyl lacking normal endodermal and cortical layers, has reduced adventitious root formation. Additionally, we find enhanced expression of

SCR-GFP in excised seedlings in the endodermal layer compared to the expression in an intact hypocotyl. This finding is consistent with a previous study which found that

SCARECROW- like GRAS transcription factors were induced by auxin in rooting competent stem cuttings of Pinus radiata and Castanea sativa (Sanchez et al., 2007).

We examined the role of auxin in adventitious root formation, as this hormone has been shown to have an essential role in initiation and development of lateral root formation. Adventitious root formation is dependent on shoot derived auxin, as removal

63 of shoot apex or treatment with NPA inhibits adventitious root formation. Additionally,

we have found that exogenous IAA treatment enhances adventitious root formation in

both intact and root excised seedlings. To define the mechanisms by which auxin controls

this process, we examined the adventitious rooting phenotype of a number of mutants

altered in auxin signaling, with a particular focus on mutants that alter lateral root

development. A surprisingly large number of mutants showed no defect in adventitious

root formation (tir1, axr1, iaa14, iaa17, and axr4). The most profound phenotypes were

found in the iaa3, arf7, and arf19 mutants. These mutants, particularly iaa3 and arf7, have been isolated for their strong shoot phenotype, altered hypocotyl growth, and altered shoot gravity response, respectively (Tian and Reed, 1999; Stowe-Evans et al., 1998).

These adventitious root phenotypes suggest that these auxin signaling components are involved in additional aspects of hypocotyl physiology.

Our finding that auxin regulates adventitious root formation is consistent with the few studies looking at adventitious root formation in Arabidopsis and the large amount of research in other species (reviewed in Li et al., 2009). The Arabidopsis mutants argonoute and superroot have reduced and enhanced adventitious root formation, respectively, due to altered auxin signaling and enhanced IAA synthesis (Sorin et al.,

2006; Sorin et al., 2005). Additionally, adventitious root formation was found to be regulated by a network of auxin response factors (ARFs), as arf17 mutant has enhanced, while arf6 and arf8 mutants have reduced development of adventitious root formation

(Gutierrez et al., 2009). Moreover these auxin response factors were regulated through miRNA mediated post transcriptional modifications. These results indicate that

64 development of adventitious root formation is controlled by a complex network of auxin

signaling.

We asked if the mechanism by which excision enhanced root formation is to

change auxin distribution and/or signaling. Induction of adventitious root formation after

root excision is preceded by enhanced expression of auxin induced reporters with

temporal and spatial resolution that suggests a role in root formation. This localized

auxin induced gene expression is above the position of root excision and at the location

of adventitious root formation. Moreover, IAA transport increased after removal of roots

compared to intact hypocotyls and this change preceded initiation of adventitious roots.

We did not see an overall change in free IAA levels with excision. These results are

consistent with auxin transport and local accumulation mediating formation of

adventitious roots.

To understand the mechanisms for excision increased auxin transport, we used a

genetic approach to identify auxin transport proteins that provide the auxin needed for

adventitious root formation after root excision. The abcb19/mdr1/pgp19 and pin1-1 mutants have reduced adventitious root formation indicating that ABCB19 and PIN1 mediate auxin transport required for adventitious root formation. Over-expressing lines of

ABCB19 had enhanced auxin transport and adventitious root formation, consistent with

ABCB19 mediating auxin transport required for adventitious root formation. On the other hand, aux1, pin2, pin3, and pin7 mutants did not show any reduction in adventitious root formation, suggesting a limited role of these transport proteins in development of adventitious roots. We also find that root excision leads to an increase in transcript

abundance of an auxin transport protein PIN1, while ABCB19 transcript levels were

65 unaltered. Only one report has implicated a specific auxin transport protein in regulation of adventitious root formation, with a pin1 mutant in rice showing reduced number of adventitious roots (Xu et al., 2005).

The finding of a specific role for PIN1 and ABCB19 in adventitious root formation is consistent with genetic studies of lateral root formation that have identified specific auxin transport proteins that regulate this process. aux1 mutants, defective in an influx carrier, have reduced number of lateral roots while an increase in AUX1 expression in pericycle cells drives formation of lateral roots (Laskowski et al., 2008).

Additionally, localized auxin-induced expression of LAX3 has been shown to drive emergence of lateral root primordia (Swarup et al., 2008). Defects in efflux carriers have been shown to affect lateral root formation as mutants pin2, and pin3 have altered lateral root density (Laskowski et al., 2008). These results suggest that changes in expression of

IAA transport proteins modulate primordia formation in roots.

To further understand the mechanism of enhanced IAA transport after excision, we looked at pABCB19::ABCB19:GFP, a protein GFP fusion, and found that it was expressed more in the cells of hypocotyls of excised seedlings than in intact hypocotyls.

This enhanced expression of this protein fusion was not associated with parallel changes in ABCB19 transcript levels, as judged by qRT-PCR or by fluorescent measurements with a pABCB19::GFP transcriptional construct, suggesting a possible involvement of post-transcription stabilization of ABCB19 protein during adventitious root formation.

We examined the role of protein phosphorylation in development of adventitious roots using inhibitor treatments, and found that treatment of wild type with the phosphatase inhibitor, canthardin, delocalizes emergence of adventitious root formation without

66 altering the absolute numbers of roots formed relative to untreated wild-type. Consistent with this, wild-type hypocotyl transport is reduced with canthardin treatment. But no effect on adventitious root formation was seen with treatment of the kinase inhibitor staurosporine, and in the pid-9 mutant defective in protein kinase (Bennett et al., 1995)

(data not shown), or in the rcn1 mutant defective in the phosphatase 2A subunit, which regulates hypocotyl growth and gravity responses (Deruere et al., 1999; Muday et al.,

2006) (data not shown). The absence of cantharidin effects in the abcb19 mutant suggests that this protein may be a target of dephosphorylation. Consistent with this hypothesis, pABCB19:: ABCB19:GFP fluorescence was reduced with canthardin treatment. This suggests that dephosphorylation might activate ABCB19, which then drives auxin transport required for localized auxin accumulation above the site of excision, resulting in formation of adventitious roots above the site of excision.

Our results are consistent with the previously established role of protein phosphorylation in regulation of auxin transport and related physiology (Friml et al.,

2004; Rashotte et al., 2001; DeLong et al., 2002). The pid 9 and rcn1 mutants have decreased and increased root basipetal transport, respectively, and altered gravity response (Sukumar et al., 2009; Rashotte et al., 2001). Additionally, treatments that inhibit kinase and phosphatase activities alter auxin gradients required for gravity response (Sukumar et al., 2009). Furthermore, kinase inhibitor treatments and PID mutations resulted in enhanced accumulation of PIN2 in endomembrane structures, without altering the PIN2 polarity (Sukumar et al., 2009), while in several studies over- expression of PID9 has been shown to alter polar localization of PIN1 (Friml et al., 2004;

Michniewicz et al., 2007; Sukumar et al., 2009; Zhang et al., 2010). Triple mutants of

67 rcn1pgp19pgp1 show severe defects in development suggesting that phosphorylation may also regulate activity of ABCB transport proteins (Mravec et al., 2008). Moreover, both PIN and ABCB proteins have possible phosphorylation sites in their sequences

(reviewed in Titapiwatanakun and Murphy, 2009; Zhang et al., 2010). Additionally, transcripts homologous to protein phosphatase 2A were found during IBA induced adventitious root formation in Arabidopsis hypocotyl explants (Ludwig-Muller et al.,

2005). Moreover, characterization of PID over-expression lines in rice have revealed that theses lines have delayed formation of adventitious roots (Morita and Kyozuka, 2007).

Absence of the rcn1 mutation showing an effect on adventitious root formation suggests that other phosphatases or its subunits might be involved in regulation of adventitious root development in our system. In essence, our experiments have uncovered an additional role for protein phosphorylation of auxin transport proteins regulating auxin- dependent growth physiological processes, yet the precise protein target of this modification remains unknown.

These results give information on the mechanistic aspects by which root excision, a horticulturally important process, induces adventitious root formation. We have dissected the components of auxin signaling, accumulation, and transport driving this process. Excision-induced adventitious root formation is regulated by enhanced auxin movement mediated by PIN1 and ABCB19 and by localized changes in auxin accumulation. Additionally, we have found that post-transcription regulation of ABCB19 modulates auxin transport as well as the location of adventitious root development.

Together these results reveal a new role for ABCB19-mediated auxin transport in regulating root formation from hypocotyls.

68 Methods

Plant materials and chemicals

Columbia and Wassilewskija ecotypes were mainly used in this study. scr-1, shr-

1, pSCR::GFP were generously provided by Philip Benfey (Scheres et al., 1995;

Helariutta et al., 2000). Seeds of abcb19, pin1-1, 35S-ABCB19, pABCB19::GFP, and

pABCB19::ABCB19:GFP were kindly provided by Guosheng Wu and Edgar Spalding

(Wu et al., 2007). AtGH3-2GUS line19 was provided by Gretchen Hagen (Li et al., 1999).

AtCYC B1;1:GUS was provided by Maria Ivanchenko (DiDonato et al., 2004). pin7

seeds were provided by Marta Laskowski (Laskowski et al., 2008). arf7, arf19, arf7-

arf19, and iaa3 were provided by Jason Reed (Wilmoth et al., 2005;Tian et al., 2002). All

the other mutants were received from the ABRC stock center.

IAA was purchased from MP Biochemicals (Solon, Ohio). [3H]IAA (24 and 20 Ci

mmol–1) was purchased from Amersham or American Radiolabeled Chemicals. NPA was

purchased from Chemical Services (West Chester, PA). 5 Bromo-4chloro-3indoyl-β-D-

Glu UA cyclohexylamine salt was purchased from Gold biotechnology (St. Louis, MO).

RNA isolation kit was purchased from Qiagen (Qiagen plant RNeasy kit). Components of

RNAse treatment, and cDNA synthesis were purchased from Invitrogen (Carlsbad, CA).

Reagents for DNAse treatment was purchased from Promega (Madison, Wisconsin).

SYBRgreen reagent was purchased from Applied Biosystems. All other chemicals were purchased from Sigma (St. Louis, MO).

Plant growth conditions and quantification of adventitious roots

Seeds were sterilized by soaking in 95% ethanol (v/v) and 20% Bleach (v/v) with

69 10% Triton X-100(v/v) for 5 min each and then washed 5 times with sterilized water.

Seeds were then plated in sterile agar medium containing 0.8% (w/v) Type M agar (A-

4800, Sigma), 1× MS nutrients (macro and micro salts), vitamins (1 µg⋅mL−1 thiamine, 1

µg⋅mL−1 pyridoxine HCl, and 0.5 µg⋅mL−1 nicotinic acid), 1.5% (w/v) sucrose, 0.05%

(w/v) MES, with pH adjusted to 5.8 with 1N KOH before autoclaving. Plates were placed

in racks in a vertical orientation under light intensity of 3-5µmol m–2 s–1 for 5 days to

induce hypocotyl elongation.

Five day old low light grown seedlings were used in the experiments with or without excision using Neuro clipper scissors (Fine Science Tools) at a position 5-7.5 mm from shoot apex excision. They were allowed to grow for 7 more days under a light intensity of 85-100 µmol m–2 s–1. Adventitious roots were quantified on the 7th day unless

otherwise indicated using a dissecting microscope. DIC images of developing

adventitious roots were taken using a Zeiss Axio observer inverted microscope.

Fixing and clearing

Seedlings were fixed in a solution containing 10% (v/v) formaldehyde, 5% (v/v)

acetic acid and 50% (v/v) ethanol, overnight at 4 0C. Then clearing was done using

chloral hydrate:glycerol:water solution (8:1:2, w:v:v), at room temperature, as described

in Fukaki et. al (1998). Cleared seedlings were mounted in 95% ethanol and visualized.

β –Glucuronidase staining

AtGH3:GUS or AtCYCB1;1:GUS transgenic seedlings were incubated in 2 mM

GUS substrate (100 mM sodium phosphate buffer, 0.5% Triton X, 2 mM X-gluc salt, 0.5

70 mM ferricyanide and 0.5 mM ferrocyanide) at 37o C overnight. Samples were then

washed with 100mM sodium phosphate buffer, pH 7 and stored in 95% ethanol. The

samples were cleared, and analyzed for localization of GUS staining using an Epi-

Fluorescent Stereomicroscope (Leica MZ16 FA).

Applications of IAA, NPA, canthardin, and staurosporine

10mM stocks of IAA and NPA were made in ethanol and DMSO, respectively.

For global treatment, IAA or NPA were added to the agar growth medium cooled to 50o

C at indicated concentrations. All experiments involving IAA treatments were placed

under fluorescent lights with yellow filters (Stasinopoulos and Hangarter, 1989) to prevent white light induced degradation of IAA. For local applications, indicated

chemicals were added in 1% agar in 5mM MES, pH 5.5 at 50o C and placed in scintillation vials. 1mm agar cylinders were obtained by using sterile plastic transfer pipettes to cut cores from the solidified agar. Localized application of NPA was done as a second agar cylinder below the agar cylinder containing IAA. Observations on position and number of emerged adventitious roots were performed after 7 days using a dissecting microscope.

10mM stock solutions of canthardin and staurosporine were made in DMSO.

Canthardin or staurosporine was added to the agar growth media cooled to 50o C at

indicated concentrations for 48hrs and 7days to measure IAA transport and adventitious

root formation, respectively.

71 Confocal Microscopy

GFP fluorescence was observed using Zeiss LSM710 Meta fluorescence laser

scanning confocal microscope using either the GFP channel (J0121:GFP, SCR::GFP) or

lambda scanning (ABCB19 lines) at 494-649nm, with samples mounted in deionized

water. Chloroplast and GFP signals were separated using linear unmixing settings of

Zeiss Zen software. Quantification of GFP signals were performed using linear profiles

through the longitudinal sides of the cells using Zeiss Zen software. Tile scanning of

hypocotyls were done using 3 vertical and 7 horizontal setting in the Zeiss software. All

pictures within an experiment were taken under similar settings, unless indicated

otherwise.

Auxin transport

Auxin transport measurements in the hypocotyls were done by modifying a previously published method (reviewed in Lewis and Muday, 2009). 5 day old low light

grown seedlings; either intact or excised, were transferred to control plates and their

shoot apex was removed. An agar cylinder or agar droplets with tritiated IAA with

approximate concentration of 100nM was applied at the shoot end and incubated in the

dark for 3 hrs. 3mm sections were removed from the basal end from the excised (and at a

similar position from the intact) hypocotyls after 3 hrs and were used for quantification

using a Beckman LS 6500 scintillation counter.

RNA isolation and Quantitative Real time PCR measurements

Low light grown seedlings were transferred to high light conditions for 6hrs.

72 Hypocotyl tissues were harvested from excised seedlings and were frozen in liquid

nitrogen. As controls, intact seedlings were excised and were frozen immediately. Total

RNA was isolated using Qiagen plant minieasy kit, after homogenization of tissue

samples. DNAase treatments were performed and RNA samples were equilibrated.

cDNA reactions were performed followed by RNAase treatment. cDNA samples were

run in 96 well plate in a real time PCR machine (Applied Biosystems 7600-fast thermal

cycler) using target specific primers, deionized water, and SYBR green reagent.

Transcript levels were calculated relative to actin in each sample using the standard curve meghod.

The primers used were ABCB19- Forward: CAGGAAATGGTTGGTACTCGAGAT,

Reverse: GAATGGCTCAAACGGGTT. PIN1-Forward:

ATCACCTGGTCCCTCATTTC, Reverse: CCATGAACAACCCAAGACTG. Actin-

Forward: TGAGAGATTCAGATGCCCAGAA, Reverse:

GCAGCTTCCATTCCCACAA.

Supplemental Methods:

Quantification of free IAA

For quantification of free IAA levels, 5 day old low light seedlings were transferred to high light conditions with or without excision, and hypocotyl tissues were harvested at various time points and frozen in liquid nitrogen. About 50-80mg of frozen tissues were homogenized using 150µl of homogenization buffer (65% isopropanol, 35%

13 0.2M imidazole, pH 7), incubated with internal standard ( C6)- IAA, followed by

centrifugation at 10,000g for 8 min. Free IAA was extracted by running through two

73 automated successive columns followed by methylation, drying and redissolving in ethyl acetate (Barkawi et al., 2008). Quantification was done using GC-SIM-MS through isotope dilution analysis and values are reported relative to fresh weight in ng/gFW.

Acknowledgements

We appreciate Sangeeta Negi, Daniel Lewis, and Hanya Chrispeels for their thoughtful comments. We thank Marta Laskowski, Philip Benfey, Gretchen Hagen, and

Edgar Spalding for sharing mutant and transgenic Arabidopsis seeds. We appreciate the microscopy assistance of Anita McCauley and Daniel Lewis.

74 Literature cited

Barkawi LS, Tam YY, Tillman JA, Pederson B, Calio J, Al-Amier H, Emerick M,

Normanly J, Cohen JD (2008) A high-throughput method for the quantitative analysis

of indole-3-acetic acid and other auxins from plant tissue. Anal Biochem 372: 177-188

Benkova E, Michniewicz M, Sauer M, Teichmann T, Seifertova D, Jurgens G, Friml

J (2003) Local, efflux-dependent auxin gradients as a common module for plant organ

formation. Cell 115: 591-602

Bennett SRM, Alvarez J, Bossinger G, Smyth DR (1995) Morphogenesis in pinoid

mutants of Arabidopsis thaliana. Plant J. 8: 505-520

Blakeslee JJ, Bandyopadhyay A, Lee OR, Mravec J, Titapiwatanakun B, Sauer M,

Makam SN, Cheng Y, Bouchard R, Adamec J, Geisler M, Nagashima A, Sakai T,

Martinoia E, Friml J, Peer WA, Murphy AS (2007) Interactions among PIN-

FORMED and P-glycoprotein auxin transporters in Arabidopsis. Plant Cell 19: 131-147

Boerjan W, Cervera M-T, Delarue M, Beeckman T, Dewitte W, Bellini C, Caboche

M, van Onckelen H, Van Montagu M, Inze D (1995) Superroot, a recessive mutation in Arabidopsis, confers auxin overproduction. Plant Cell 7: 1405-1419

Casimiro I, Beeckman T, Graham N, Bhalerao R, Zhang HM, Casero P, Sandberg

G, Bennett MJ (2003) Dissecting Arabidopsis lateral root development. Trends in Plant

Science 8: 165-171

Casimiro I, Marchant A, Bhalerao RP, Beeckman T, Dhooge S, Swarup R, Graham

N, Inze D, Sandberg G, Casero PJ, Bennett M (2001) Auxin transport promotes

Arabidopsis lateral root initiation. Plant Cell 13: 843-852

75 Celenza JL, Grisafi PL, Fink GR (1995) A Pathway for Lateral Root-Formation in

Arabidopsis-Thaliana. Genes & Development 9: 2131-2142

De-Klerk G, Krieken W, DeJong J (1999) The formation of adventitious roots: New concepts, new possibilities. In Vitro Cell Dev Biol-Plant 35: 189-199

DeLong A, Mockaitis K, Christensen S (2002) Protein phosphorylation in the delivery

of and response to auxin signals. Plant Mol Biol 49: 285-303

Deruere J, Jackson K, Garbers C, Soll D, Delong A (1999) The RCN1-encoded A

subunit of protein phosphatase 2A increases phosphatase activity in vivo. Plant J 20: 389-

399

DiDonato RJ, Arbuckle E, Buker S, Sheets J, Tobar J, Totong R, Grisafi P, Fink

GR, Celenza JL (2004) Arabidopsis ALF4 encodes a nuclear-localized protein required for lateral root formation. Plant Journal 37: 340-353

DiLaurenzio L, WysockaDiller J, Malamy JE, Pysh L, Helariutta Y, Freshour G,

Hahn MG, Feldmann KA, Benfey PN (1996) The SCARECROW gene regulates an

asymmetric cell division that is essential for generating the radial organization of the

Arabidopsis root. Cell 86: 423-433

Falasca G, Altamura M (2003) Histological analysis of adventitious rooting in

Arabidopsis thaliana (L.) Heynh seedlings. Plant Biosystems 137: 265-274

Friml J, Wisniewska J, Benkova E, Mendgen K, Palme K (2002) Lateral relocation of auxin efflux regulator PIN3 mediates in Arabidopsis. Nature 415: 806-809

Friml J, Yang X, Michniewicz M, Weijers D, Quint A, Tietz O, Benjamins R,

Ouwerkerk PBF, Ljung K, Sandberg G, Hooykaas PJJ, Palme K, Offringa R (2004)

76 A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin

efflux. Science 306: 862-865

Fukaki H, Tameda S, Masuda H, Tasaka M (2002) Lateral root formation is blocked

by a gain-of-function mutation in the SOLITARY-ROOT/IAA14 gene of Arabidopsis.

Plant Journal 29: 153-168

Fukaki H, Wysocka-Diller J, Kato T, Fujisawa H, Benfey PN, Tasaka M (1998)

Genetic evidence that the endodermis is essential for shoot gravitropism in Arabidopsis

thaliana. Plant J 14: 425-430

Galweiler L, Guan CH, Muller A, Wisman E, Mendgen K, Yephremov A, Palme K

(1998) Regulation of polar auxin transport by AtPIN1 in Arabidopsis vascular tissue.

Science 282: 2226-2230

Gutierrez L, Bussell JD, Pacurar DI, Schwambach J, Pacurar M, Bellini C (2009)

Phenotypic Plasticity of Adventitious Rooting in Arabidopsis Is Controlled by Complex

Regulation of AUXIN RESPONSE FACTOR Transcripts and MicroRNA Abundance.

Plant Cell 21: 3119-3132

Heisler MG, Ohno C, Das P, Sieber P, Reddy GV, Long JA, Meyerowitz EM (2005)

Patterns of auxin transport and gene expression during development revealed by live imaging of the Arabidopsis inflorescence meristem. Current Biology 15: 1899-

1911

Helariutta Y, Fukaki H, Wysocka-Diller J, Nakajima K, Jung J, Sena G, Hauser

MT, Benfey PN (2000) The SHORT-ROOT gene controls radial patterning of the

Arabidopsis root through radial signaling. Cell 101: 555-567

77 Hobbie L, Estelle M (1995) The Axr4 Auxin-Resistant Mutants of Arabidopsis-Thaliana

Define a Gene Important for Root Gravitropism and Lateral Root Initiation. Plant Journal

7: 211-220

King JJ, Stimart DP (1998) Genetic analysis of variation for auxin-induced adventitious

root formation among eighteen ecotypes of Arabidopsis thaliana L. Heynh. J Hered 89:

481-487

Konishi M, Sugiyama M (2003) Genetic analysis of adventitious root formation with a novel series of temperature-sensitive mutants of Arabidopsis thaliana. Development 130:

5637-5647

Laplaze L, Parizot B, Baker A, Ricaud L, Martiniere A, Auguy F, Franche C,

Nussaume L, Bogusz D, Haseloff J (2005) GAL4-GFP enhancer trap lines for genetic

manipulation of lateral root development in Arabidopsis thaliana. Journal of

Experimental Botany 56: 2433-2442

Laskowski M, Grieneisen VA, Hofhuis H, Hove CA, Hogeweg P, Maree AF, Scheres

B (2008) Root system architecture from coupling cell shape to auxin transport. PLoS Biol

6: e307

Lewis DR, Muday GK (2009) Measurement of auxin transport in Arabidopsis thaliana.

Nat Protoc 4: 437-451

Lewis DR, Wu GS, Ljung K, Spalding EP (2009) Auxin transport into cotyledons and

cotyledon growth depend similarly on the ABCB19 Multidrug Resistance-like transporter.

Plant Journal 60: 91-101

78 Leyser HMO, Pickett FB, Dharmasiri S, Estelle M (1996) Mutations in the AXR3

gene of Arabidopsis result in altered auxin response including ectopic expression from

the SAUR-AC1 promoter. Plant Journal 10: 403-413

Li S, Xue L, Xu S, Feng H, An L (2009) Mediators, Genes and signaling in

Adventitious rooting. Bot.Rev 75: 230-247

Li Y, Wu Y, Hagen G, Guilfoyl T (1999) Expression of the auxin-inducible GH3 promoter/GUS fusion gene as a useful molecular marker for auxin physiology. Plant Cell

Physiol 40: 675-682

Liu HJ, Wang SF, Yu XB, Yu J, He XW, Zhang SL, Shou HX, Wu P (2005) ARL1, a

LOB-domain protein required for adventitious root formation in rice. Plant Journal 43:

47-56

Liu SP, Wang JR, Wang L, Wang XF, Xue YH, Wu P, Shou HX (2009) Adventitious root formation in rice requires OsGNOM1 and is mediated by the OsPINs family. Cell

Research 19: 1110-1119

Ludwig-Muller J, Vertocnik A, Town CD (2005) Analysis of indole-3-butyric acid- induced adventitious root formation on Arabidopsis stem segments. Journal of

Experimental Botany 56: 2095-2105

Malamy J (2005) Intrinsic and environmental response pathways that regulate root system architecture. Plant Cell Environ 28: 67-77

Malamy J, Benfey P (1997) Organization and cell differentiation in lateral roots of

Arabidopsis thaliana. Development 124: 33-44

Malamy JE, Benfey PN (1997) Down and out in Arabidopsis: the formation of lateral roots. Trends Pl. Sci. 2: 390-396

79 Marchant A, Bhalerao R, Casimiro I, Eklof J, Casero PJ, Bennett M, Sandberg G

(2002) AUX1 promotes lateral root formation by facilitating indole-3-acetic acid

distribution between sink and source tissues in the Arabidopsis seedling. Plant Cell 14:

589-597

Marchant A, Kargul J, May ST, Muller P, Delbarre A, Perrot-Rechenmann C,

Bennett MJ (1999) AUX1 regulates root gravitropism in Arabidopsis by facilitating

auxin uptake within root apical tissues. Embo Journal 18: 2066-2073

Michniewicz M, Zago M, Abas L, Wijers D, Schweighofer A, Meskiene I, Heisler M,

Ohno C, Zhang J, Huang F, Schwab R, Weigle D, Meyerowitz E, Luschnig C,

Offringa R, Friml J (2007) Antagonistic regulation of PIN phosphorylation by PPSA

and PINOID directs auxin flux. Cell 130: 1044-1056

Morita Y, Kyozuka J (2007) Characterization of OsPID, the rice ortholog of PINOID, and its possible involvement in the control of polar auxin transport. Plant and Cell

Physiology 48: 540-549

Mravec J, Kubes M, Bielach A, Gaykova V, Petrasek J, Skupa P, Chand S, Benkova

E, Zazimalova E, Friml J (2008) Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development. Development 135: 3345-3354

Muday GK, Brady SR, Argueso C, Deruere J, Kieber JJ, DeLong A (2006) RCN1- regulated phosphatase activity and EIN2 modulate hypocotyl gravitropism by a mechanism that does not require ethylene signaling. Plant Physiol 141: 1617-1629

Noh B, Bandyopadhyay A, Peer WA, Spalding EP, Murphy AS (2003) Enhanced gravi- and phototropism in plant mdr mutants mislocalizing the auxin efflux protein PIN1.

Nature 423: 999-1002

80 Noh B, Murphy AS, Spalding EP (2001) Multidrug resistance-like genes of

Arabidopsis required for auxin transport and auxin-mediated development. Plant Cell 13:

2441-2454

Okada K, Ueda J, Komaki MK, Bell CJ, Shimura Y (1991) Requirement of the auxin

polar transport system in early stages of Arabidopsis floral bud formation. Plant Cell 3:

677-684

Peret B, De Rybel B, Casimiro I, Benkova E, Swarup R, Laplaze L, Beeckman T,

Bennett MJ (2009) Arabidopsis lateral root development: an emerging story. Trends

Plant Sci 14: 399-408

Rashotte AM, DeLong A, Muday GK (2001) Genetic and chemical reductions in

protein phosphatase activity alter auxin transport, gravity response, and lateral root

growth. Plant Cell 13: 1683-1697

Reed RC, Brady SR, Muday GK (1998) Inhibition of auxin movement from the shoot

into the root inhibits lateral root development in arabidopsis. Plant Physiology 118: 1369-

1378

Sanchez C, Vielba J, Ferro E, Covelo G, Sole A, Abarca D, Demier B, Diaz-Sala C

(2007) Two SCARE CROW-LIKE genes are induced in response to exogenous auxin in rooting-competent cuttings of distantly related forest species. Tree Physiology 27: 1459-

1470

Sauer M, Balla J, Luschnig C, Wisniewska J, Reinohl V, Friml J, Benkova E (2006)

Canalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of PIN polarity. Genes & Development 20: 2902-2911

81 Scheres B, Dilaurenzio L, Willemsen V, Hauser MT, Janmaat K, Weisbeek P,

Benfey PN (1995) Mutations Affecting the Radial Organization of the Arabidopsis Root

Display Specific Defects Throughout the Embryonic Axis. Development 121: 53-62

Sorin C, Bussell JD, Camus I, Ljung K, Kowalczyk M, Geiss G, McKhann H,

Garcion C, Vaucheret H, Sandberg G, Bellini C (2005) Auxin and light control of adventitious rooting in Arabidopsis require ARGONAUTE1. Plant Cell 17: 1343-1359

Sorin C, Negroni L, Balliau T, Corti H, Jacquemot MP, Davanture M, Sandberg G,

Zivy M, Bellini C (2006) Proteomic analysis of different mutant genotypes of

Arabidopsis led to the identification of 11 proteins correlating with adventitious root development. Plant Physiology 140: 349-364

Stasinopoulos TC, Hangarter RP (1989) Preventing photochemistry in culture media by long-pass light filters alters growth of cultured tissues. Plant Physiol 93: 1365-1369

Stowe-Evans EL, Harper RM, Motchoulski AV, Liscum E (1998) NPH4, a conditional modulator of auxin-dependent differential growth responses in Arabidopsis.

Plant Physiol 118: 1265-1275

Sukumar P, Edwards KS, Rahman A, Delong A, Muday GK (2009) PINOID kinase regulates root gravitropism through modulation of PIN2-dependent basipetal auxin transport in Arabidopsis. Plant Physiol 150: 722-735

Swarup K, Benkova E, Swarup R, Casimiro I, Peret B, Yang Y, Parry G, Nielsen E,

De Smet I, Vanneste S, Levesque MP, Carrier D, James N, Calvo V, Ljung K,

Kramer E, Roberts R, Graham N, Marillonnet S, Patel K, Jones JDG, Taylor CG,

Schachtman DP, May S, Sandberg G, Benfey P, Friml J, Kerr I, Beeckman T,

82 Laplaze L, Bennett MJ (2008) The auxin influx carrier LAX3 promotes lateral root

emergence. Nature Cell Biology 10: 946-954

Swarup K, Benková E, Swarup R, Casimiro I, Péret B, Yang Y, Parry G, Nielsen E,

De Smet I, Vanneste S, Levesque MP, Carrier D, James N, Calvo V, Ljung K,

Kramer E, Roberts R, Graham N, Marillonnet S, Patel K, Jones JDG, Taylor CG,

Schachtman DP, May S, Sandberg G, Benfey P, Friml J, Kerr I, Beeckman T,

Laplaze L, Bennett MJ (2008) The auxin influx carrier LAX3 promotes lateral root

emergence. Nature Cell Biology In Press

Teale WD, Paponov IA, Palme K (2006) Auxin in action: signalling, transport and the

control of plant growth and development. Nature Reviews Molecular Cell Biology 7:

847-859

Tian Q, Reed JW (1999) Control of auxin-regulated root development by the

Arabidopsis thaliana SHY2/IAA3 gene. Development 126: 711-721

Tian Q, Uhlir NJ, Reed JW (2002) Arabidopsis SHY2/IAA3 inhibits auxin-regulated gene expression. Plant Cell 14: 301-319

Titapiwatanakun B, Murphy AS (2009) Post-transcriptional regulation of auxin transport proteins: cellular trafficking, protein phosphorylation, protein maturation, ubiquitination, and membrane composition. Journal of Experimental Botany 60: 1093-

1107

Van Hoewyk D, Takahashi H, Inoue E, Hess A, Tamaoki M, Pilon-Smits E (2008)

Transcriptome analyses give insights into selenium-stress responses and selenium tolerance mechanisms in Arabidopsis. Physiol Plant 132: 236-253

83 Wilmoth JC, Wang S, Tiwari SB, Joshi AD, Hagen G, Guilfoyle TJ, Alonso JM,

Ecker JR, Reed JW (2005) NPH4/ARF7 and ARF19 promote leaf expansion and auxin-

induced lateral root formation. Plant J 43: 118-130

Wu G, Lewis DR, Spalding EP (2007) Mutations in Arabidopsis multidrug resistance-

like ABC transporters separate the roles of acropetal and basipetal auxin transport in

lateral root development. Plant Cell 19: 1826-1837

Xu M, Zhu L, Shou HX, Wu P (2005) A PIN1 family gene, OsPIN1, involved in auxin-

dependent adventitious root emergence and tillering in rice. Plant and Cell Physiology

46: 1674-1681

Zadnikova P, Petrasek J, Marhavy P, Raz V, Vandenbussche F, Ding ZJ,

Schwarzerova K, Morita MT, Tasaka M, Hejatko J, Van Der Straeten D, Friml J,

Benkova E (2010) Role of PIN-mediated auxin efflux in apical hook development of

Arabidopsis thaliana. Development 137: 607-617

Zhang J, Nodzynski T, Pencik A, Rolcik J, Friml J (2010) PIN phosphorylation is

sufficient to mediate PIN polarity and direct auxin transport. Proceedings of the National

Academy of Sciences of the United States of America 107: 918-922

84 CHAPTER III

AUXIN-ETHYLENE CROSS TALK DRIVES ADVENTITIOUS ROOT FORMATION

IN ARABIDOPSIS

Sukumar P., Lewis D.R., Muday G.K.

The following manuscript is to be submitted for publication. Sukumar P. performed most of the experiments and prepared the manuscript. Lewis D.R. performed experiments in

Figure 4 D&E. Muday G.K. acted in an advisory and editorial capacity.

85 Abstract

While studies in agriculturally important species of plants have provided

contradictory evidence on the role of ethylene in adventitious root formation, the genetic

tools in Arabidopsis thaliana (Arabidopsis) have not been exploited to provide insight

into this process. We examined the role of ethylene in adventitious root formation using

mutants in ethylene signaling or synthesis, and find that treatment with the ethylene

precursor ACC (1-aminocyclopropane-1-carboxylic acid) or the eto1 (ethylene over producing1) mutation led to fewer adventitious roots. In contrast, the ethylene insensitive mutants, ein2-5 and etr1-1, had increased number of adventitious roots. Consistent with their adventitious root phenotypes, eto1 had reduced auxin transport, while ein2-5 had enhanced transport, suggesting that ethylene negatively regulates hypocotyl auxin transport and adventitious root formation. Additionally the fluorescence of an auxin efflux carrier protein fusion, pABCB19::ABCB19:GFP (ATP BINDING CASSETTE

TYPE B), was reduced by ACC treatment. Moreover, abcb19 mutants were insensitive to reduction of adventitious roots with ACC treatment, indicating ABCB19 levels regulated this ethylene response. Excision enhanced accumulation of flavonoids, through increased expression of the gene encoding the flavonoid biosynthetic enzyme, chalcone synthase

(CHS). We find that the tt4-2 (transparent testa 4) mutant, which has a defect in CHS, exhibits partial insensitivity to excision-induced adventitious root formation and elevated auxin transport and ACC inhibition of both processes. These results suggest a possible auxin-ethylene cross talk regulating adventitious root formation in Arabidopsis, with ethylene regulating auxin transport and accumulation, through modulating flavonoid accumulation and ABCB19 protein levels.

86 Introduction

Ethylene is a gaseous plant hormone that regulates various development processes such as and and whose synthesis is induced upon wounding, pathogen attack, and other situations of stress, including flooding (reviewed in Bleecker and Kende, 2000). Recent studies have examined the effects of ethylene on lateral root development, with ethylene inhibiting lateral root formation in both Arabidopsis and

Solanum lycopersicum (tomato) (Negi et al., 2008; Negi et al., 2010). The effect of ethylene on adventitious root formation is less clear with ethylene promoting adventitious root formation in some species, while in other species ethylene decreases adventitious root formation (reviewed in De-Klerk et al., 1999; Clark et al., 1999; Coleman et al.,

1980; Nordstrom and Eliasson, 1984). No studies have utilized the genetic tools available in Arabidopsis to identify mechanisms by which ethylene acts in this process.

The pathways of ethylene signaling and synthesis have been identified through genetic approaches in Arabidopsis. The ethylene signaling pathway is mediated by a receptor family including ETR1 (ETHYLENE RESISTANT 1) (Bleecker et al., 1988).

Binding of ethylene to its receptor inactivates CTR1 (CONSTITUTIVE TRIPLE

RESPONSE 1), which encodes a kinase that is implicated in a MAPKKK cascade

(Kieber et al., 1993). Both receptors and CTR1 negatively regulate this pathway (Kieber,

1997). Downstream of CTR1 is EIN2 (ETHYLENE INSENSITIVE 2), an Nramp metal ion transporter, which is required for ethylene signaling (Alonso et al., 1999). EIN3

(ETHYLENE INSENSITVE 3) and EILs (EIN3 LIKE) are a group of transcription factors that regulate the expression of ethylene induced genes (Chao et al., 1997;

Bleecker and Kende, 2000; Potuschak et al., 2003). Ethylene biosynthesis begins with

87 formation of ACC (Aminocyclopropane-1-carboxylic acid) by the enzyme ACC synthase

(ACS), which is then converted to ethylene by the enzyme ACC oxidase (Argueso et al.,

2007). ACS is modulated by ETO (ETHYLENE OVERPRODUCER), which regulates

its protein stability (Chae et al., 2003). Plants with mutations in ethylene signaling or

synthesis genes have provided valuable insights into the physiological processes

mediated by ethylene.

One such process tied to ethylene signaling is the triple response, which was

exploited in the isolation of mutants altered in ethylene signaling and synthesis. The triple

response consists of reduced elongation of the root and shoot, swelling of the stem, and

exaggerated hook formation in etiolated seedlings treated with ethylene (Bleecker et al.,

1988; reviewed in Bleecker and Kende, 2000; Knee et al., 2000). This ethylene mediated

hypocotyl growth regulation is not only involved in growth of plants in the dark, but also

while growing in light and is shown to occur through crosstalk with auxin in some, but

not all, studies (Smalle et al., 1997; Collett et al., 2000). Additionally, light induced

changes in ethylene sensitivity were shown to be important in opening of hypocotyl

hooks (Knee et al., 2000). Therefore numerous aspects of hypocotyl growth and

development are ethylene regulated.

Ethylene is also involved in regulating root elongation and development. Root

elongation is synergistically inhibited by auxin and ethylene (Ruzicka et al., 2007;

Stepanova et al., 2007; Swarup et al., 2007). Auxin and ethylene promote root hair

formation in an interdependent manner requiring both auxin and ethylene signaling

pathways for this induction (Rahman et al., 2002). Additionally, auxin and ethylene were

shown to oppositely modulate lateral root development (Negi et al., 2008; Ivanchenko et

88 al., 2008). In Arabidopsis, etr1 and ein2 have enhanced lateral root formation, while eto1

and ctr1 have reduced formation of lateral roots (Negi et al., 2008). Similarly, the tomato

NR (Never ripe) mutant, which has a defect in a gene encoding an ethylene receptor, has

enhanced formation of lateral roots (Negi et al., 2010). Moreover, in tomato, NR mutants had reduced formation of adventitious roots (Negi et al., 2010). Consistent with a promotive effect of this hormone, treatment with the ethylene precursor ACC, caused enhanced formation of adventitious roots (Negi et al., 2010). Moreover development of adventitious roots has been shown to involve auxin-ethylene crosstalk (Negi et al., 2010).

In Rumex plants, flooding induced adventitious root formation is mediated by ethylene enhanced auxin sensitivity (Visser et al., 1996). These results indicate that ethylene is an important regulator of plant growth and development and several of these physiological processes requires complex interaction of auxin and ethylene.

Few studies have examined the mechanisms by which ethylene-auxin crosstalk occurs at the level of signaling, synthesis, and/or transport of these hormones. Defects in auxin signaling and transport render roots less sensitive to the inhibition of root elongation via ethylene treatment (Rahman et al., 2001). Conversely, defects in ethylene signaling can alter root development in response to auxin (Negi et al., 2010; Negi et al.,

2008; Clark et al., 1999). Auxin accumulation is enhanced with ethylene precursor treatments in roots and seedlings (Stepanova et al., 2007; Swarup et al., 2007). Moreover, the weak ethylene insensitive mutants, wei1 and wei7, defective in ethylene inhibition of root elongation, have mutations in genes encoding enzymes involved in auxin biosynthesis (Stepanova et al., 2005). Additionally, auxin can induce ethylene biosynthesis during adventitious root formation (Riov and Yang, 1989; Visser et al.,

89 1996). Furthermore, ethylene enhances auxin transport, while it inhibits the formation of lateral roots in Arabidopsis and tomato. The ethylene effect on lateral root formation is lost in auxin transport mutants, suggesting that the effect acts through these auxin transport proteins (Negi et al., 2008). One mechanism by which ethylene regulates auxin transport is through enhanced accumulation of flavonoids (Buer et al., 2006; Lewis et al., in review). Flavonoids negatively regulate auxin transport and alter root gravity response and lateral root formation (Buer and Muday, 2004; Buer et al., 2006; Brown et al., 2001).

These results suggest that flavonoids are important in auxin-ethylene cross talk. The diversity of Arabidopsis mutants with altered ethylene and auxin signaling, synthesis, and transport can be used to identify mechanisms of auxin-ethylene cross talk driving adventitious root formation.

Our previous research has revealed the role of auxin in regulating adventitious root formation in Arabidopsis (Sukumar and Muday, in review). Moreover, research from other species of plants suggests that ethylene might also be involved in regulation of adventitious root development (Clark et al., 1999; reviewed in De-Klerk et al., 1999; Li et al., 2009). The purpose of these experiments is to understand the role of ethylene in regulation of development of adventitious roots and to uncover possible cross talk between the two plant hormones auxin and ethylene. These studies use a method to induce adventitious root formation (Sukumar and Muday, in review) and have examined this phenotype in mutants defective in ethylene signaling or synthesis. Using these mutants, a role for ethylene in this process has been identified. We have observed changes in auxin transport in these mutants and have identified ethylene-induced changes in abundance of an auxin transport protein and flavonoids, endogenous auxin transport

90 regulators, which are required for maximal development of adventitious roots. Together these results have provided new insights into ethylene regulation of auxin transport and accumulation driving the formation of adventitious roots.

91 Results

Ethylene negatively regulates adventitious root formation

We have utilized the genetic tools in Arabidopsis to ask if ethylene regulates

adventitious root development. Arabidopsis seedlings were grown under low light

conditions (5-10 µmoles/m2/min) for 5 days and were transferred to high light conditions

(80-100 µmoles/m2/min) on media with or without ACC. At the time of transfer, the

basal half of the shoot and the root system were excised (from here on referred to as root

excised hypocotyls), as this regime was found to enhance adventitious root formation 10-

fold relative to intact hypocotyls (Sukumar and Muday, in review). The number of

emerged adventitious roots on control media and media with the indicated concentrations

of the ethylene precursor, ACC, was quantified after seven days of growth, as shown in

Figure III-1A. At concentrations of 10 and 25 µM, ACC significantly reduced

adventitious root formation (p< 0.005), suggesting a negative role of ethylene on

development of adventitious roots. The magnitude of the inhibition was approximately

25%, consistent with significant endogenous ethylene present in these seedlings.

To confirm the effect of ACC on adventitious root formation, we examined the

adventitious root phenotype in ethylene signaling and synthesis mutants; the ethylene

insensitive mutants: ein2-5 and etr1-1, the ethylene over producer: eto1-1, and the

constitutive ethylene signaling mutant: ctr1-1, as shown in Figure III-1B. The ein2-5

mutant had significantly greater number of adventitious roots (1.4-fold increase), while

eto1-1 and ctr1-1 had significantly fewer adventitious roots, with 20% and 50%

inhibition, respectively (p< 0.005). These effects are consistent with endogenous ethylene

negatively regulating adventitious root formation in Arabidopsis.

92

A D 6 5 * * 4 3 2 1 0

Number of adventitious roots adventitious Number of 0 1 10 25 [ACC], µM B

160 140 * Untreated 120 100 80 * 60 * 40 20 roots, % of wild type % of roots,

Number of adventitious of Number 0 WT ein2-5 eto1-1 ctr1-1 C

160 140 Canthardin 120 100 80 60 * 40 20 0 WT ein2-5 eto1-1 ctr1-1 ith canthardin,% of untreated of canthardin,% ith Number of adventitious roots adventitious of Number

w

Figure III-1: Ethylene negatively affects adventitious root formation and is induced with excision.

93 (A) Adventitious root formation was quantified in root excised seedlings treated with the

indicated concentrations of ACC. Average ± SE of 15-69 seedlings are given. Values are

compared to untreated controls by Student’s t test. *p≤ 0.05.

(B) Adventitious root formation was quantified in root excised seedlings of ethylene

mutants. Average ± SE of 19-30 seedlings are given. Values are compared to wild-type

by Student’s t-test. * p≤ 0.05.

(C) Quantification of adventitious root formation, 7 days after excision, in wild type, ein2-5, eto1-1, and ctr1-1 mutants with canthardin treatment. Average ± SE of 9-31 seedlings are given. Values are compared by Student’s t-test. *p≤ 0.05.

(D) Images of wild type, ein2-5, and eto1-1 mutants with or without canthardin treatment taken using a stereomicroscope. Arrows point to the site of excision and arrow heads point to the uppermost emerged adventitious roots relative to shoot apex. Scale bar is 1 mm.

94 When roots are excised from seedlings grown under these conditions, adventitious roots emerge clustered together, 1-2 mm above the site of excision, as evident in Figure

III-1D. We asked if ethylene alters the localization of excision induced adventitious root

formation, in addition to its effect on the number of adventitious roots. To test this, we

examined the adventitious root formation in the ethylene mutants: ein2-5, eto1-1, ctr1-1,

and wild type treated with and without 25µM ACC, as shown in Figure III-1Cand D. In

all these seedlings, adventitious roots emerged approximately 1-2 mm above the site of

excision, as detected in cleared hypocotyls, suggesting that altered ethylene signaling or

synthesis does not affect the position of adventitious root formation.

Furthermore, the position of adventitious roots in root excised hypocotyls is de-

localized if seedlings are treated with the protein phosphatase inhibitor canthardin

(Sukumar and Muday, in review). We examined the adventitious root formation in

ethylene mutants ein2-5, eto1-1, ctr1-1, and wild type treated with and without ACC, in

the presence and absence of canthardin, to ask if altered ethylene signaling or synthesis

would affect this canthardin effect, as shown in Figure III-1C, 1D. Interestingly, the de-

localization effect of canthardin was seen in all of the ethylene mutants, as well as wild

type treated with ACC. The number of adventitious roots formed with canthardin in all

the mutants, except ein2-5, was similar to their respective untreated controls (Figure III-

1D), consistent with our previous observation that canthardin does not alter the number of

adventitious roots (Sukumar and Muday, in review). ACC reduced adventitious root

formation in wild type, and a combined treatment with canthardin and ACC neither had

an additional reduction beyond ACC alone in number of adventitious roots nor did this

combination change the longitudinal position of root formation relative to canthardin

95 alone. These results suggest that the canthardin altered position of adventitious root

formation occurs independently of ethylene synthesis or signaling.

ACC reduces auxin induction of adventitious root formation

Previous results have shown that auxin positively regulates adventitious root

formation in Arabidopsis. We asked whether there are interactions between ethylene and

auxin during adventitious root formation using two endogenous auxins: indole-3-acetic

acid (IAA) and indole-3-buytric acid (IBA). Although IAA is the most abundant naturally occurring auxin in plants (reviwed in Woodward and Bartel, 2005), IBA is commercially

used for induction of adventitious roots, due to its greater stability (reviwed in De-Klerk

et al., 1999). For this experiment we used intact hypocotyls, as our previous experiments

have shown a greater fold enhancement of adventitious root formation with auxin

treatment of intact hypocotyl than of root excised hypocotyls (Sukumar and Muday, in review). Five day old low light grown hypocotyls were transferred to media with either

IAA, IBA, or ACC or a combination of these compounds. Adventitious roots that emerged 7 days later in these intact seedlings were quantified and are reported in Figure

III-2A. ACC treatment slightly reduced adventitious root development in intact seedlings, which form few adventitious roots. Both IAA and IBA alone significantly increased the number of adventitious roots (p< 0.005), while a combined treatment of IAA and IBA produced the greatest number of adventitious roots. With a combined treatment of IAA and ACC, the number of adventitious roots emerged were intermediate relative to the single treatments, with a 55% reduction in adventitious roots compared to IAA treatment.

Surprisingly, an ACC and IBA combined treatment did not significantly change the

96

A 14 ad 12 WT Intact 10 ac 8 ab ac 6 a 4 ac 2

Number of adventitious roots 0 25µM _ IAA IAA _ IBA IBA IAA&IBA IAA&IBA

25µM __ACC ACC ACC __ACC

B C 16 16 Intact Excised 14 WT+IAA 14 WT+IAA ein2-5+IAA ein2-5+IAA 12 12 WT+IBA WT+IBA 10 ein2-5+IBA 10 ein2-5+IBA 8 8 6 6 4 4 2 2

0 Number of roots adventitious 0 Number of adventitious roots -∞-7 -6 -5 -4 -∞ -7 -6 -5 -4 Log auxin conc, M Log auxin conc, M

Figure III-2: Ethylene can inhibit auxin induction of adventitious root formation.

(A) Adventitious roots formed in intact seedlings treated with IAA, IBA or ACC or combination of IAA or IBA and ACC. Average ± SE of 10-30 seedlings are given.

a- Indicates significant difference as determined by Student’s t-test between untreated and treated with p< 0.05.

97 b- Indicates significant difference as determined by Student’s t-test between auxin only and combined auxin and ACC treatments c- Indicates significant difference as determined by Student’s t-test between ACC only and combined ACC and auxin treatments d- Indicates significant difference as determined by Student’s t-test between single IAA or IBA and combined auxin treatment

(B), (C) Adventitious roots formed in intact (B) or root excised (C) in wild type and, ein2-5 treated with the indicated concentrations of IAA or IBA. n=9-32

98 number of adventitious roots relative to IBA added alone. ACC with IAA and IBA induced a statistically significant 40% reduction in hypocotyls relative to IAA and IBA

treatments (p< 0.05). These results suggest the surprising finding that ethylene can inhibit

the IAA, but not the IBA induction of adventitious root formation in Arabidopsis

seedlings.

Ethylene insensitive mutants are hypersensitive to auxin induction of adventitious root

formation

We further explored auxin-ethylene cross talk by examining the effects of IAA

and IBA on adventitious root formation in the ethylene insensitive mutant ein2-5 in both

intact and root excised hypocotyls. 5 day old low light grown hypocotyls of wild type or

mutants were transferred to media with various concentrations of IAA or IBA.

Adventitious roots that emerged 7 days later were quantified and are reported in Figure

III-2B,C. There was no difference in the formation of adventitious roots between IAA

and IBA in wild type intact hypocotyls, while IAA induced more adventitious roots than

IBA in wild type excised hypocotyls. In both intact and excised hypocotyls, ein2-5

produced a greater number of adventitious roots than wild type at most concentration of

IAA and IBA. Additionally at lower concentrations, IAA had more profound effects than

IBA in both intact and excised ein2-5. Identical results were found with ethylene resistant

mutant etr1-1, as shown in Supplemental Figure III-S1. These results indicate that

ethylene insensitive mutants are hypersensitive to auxin induction of adventitious roots,

particularly IAA, and suggest that the ethylene responsiveness may inhibit the

effectiveness of auxin induction of adventitious root formation. This result is consistent

99

S1A S1B 14 14 IntactWT+IAA Excised 12 WT+IAA 12 etr1-1+IAA etr1-1+IAA 10 10 WT+IBA WT+IBA etr1-1+IBA 8 etr1-1+IBA 8 6 6 4 4 2 2 0 0 Number adventitious of roots Number adventitious of roots -∞-7 -6 -5 -4 -∞ -7 -6 -5 -4 Log auxin conc, M Log auxin conc, M

Supplemental Figure III-1: Adventitious roots formed in intact (S1A) or root excised

(S1B) in wild type and, etr1-1 treated with various concentrations of IAA, or IBA.

100 with ethylene reducing the positive effect of auxin, with interaction between ethylene and

IAA being greater than interactions with IBA, as determined by both exogenous

treatments and examination of an ethylene insensitive mutant. Although IBA can be a

precursor to IAA (reviwed in Woodward and Bartel, 2005), appears to act independently and be transported by a different set of proteins (Rashotte et al., 2005; Poupart et al.,

2005; Strader and Bartel, 2009). In parallel, IAA and IBA were found to have different kinetics for inducing ethylene accumulation in stem cuttings of mung bean (Riov and

Yang, 1989). The very different interactions between ACC and these two auxins reported

here suggests that differences between IAA and IBA transport and signaling may lead to

these different interactions with ethylene.

Ethylene negatively regulates basipetal auxin transport in hypocotyls

To test if ethylene affects hypocotyl auxin transport, we examined basipetal IAA

transport in root excised hypocotyls of wild type, ein2-5, and eto1-1. Agar droplets with

3H-IAA were applied at the shoot apical end of root excised hypocotyls, and the amounts

of 3H-IAA moving into basal sections of the hypocotyls were measured 3 hrs later and

are reported in Figure III-3A. While ein2-5 had significantly increased transport

compared to wild type, eto1-1 had significantly reduced transport relative to wild type

(p< 0.005). This suggests that ethylene negatively modulates IAA hypocotyl basipetal transport. The enhancement and reduction of IAA transport in these mutants, respectively, are consistent with their adventitious root phenotype. As a previous study showed that auxin transport from the shoot apex is essential for adventitious root formation and that

enhanced root formation after root excision increased auxin transport and adventitious

101

A B

160 18 * Intact 140 16 Excised 120 14 12 100 10 80 8 60 * 6 40 % of wild type % of 4 20 2 0 Free IAA levels, ng/gFW 0 Col ein2-5 eto1-1 Control 10µM ACC 25µM ACC

Basipetal hypocotyl transport, hypocotyl Basipetal D C 18 16 Col ein2-5 14 eto1-1 12 * 10 8 * 6 4 2 0 Free IAA levels, ng/gFW Intact Excised 48hrs 48hrs

Figure III-3: Ethylene inhibits IAA transport and free IAA levels in hypocotyls.

(A) Quantification of basipetal IAA transport in ein2-5 and eto1-1. Average ± SE of 18-

37 seedlings are given. Values are compared to wild type by Student’s t-test. * p≤ 0.005.

(B), (C) Free IAA levels were quantified in wild type, wild type treated with ACC, ein2-5 and eto1-1 using extraction and quantification using GC-Mass spec. Values are compared to wild type by Student’s t-test. * p≤ 0.005.

(D) Hypocotyls of wild type DR5:GUS and ein2-5 DR5:GUStransgenic seedlings were stained after 48hrs after root excision. Arrow head points to region of GUS product formation. Scale bars are 1mm.

102 root formation (Sukumar and Muday, in review), these results suggest that the mechanism by which ethylene reduces adventitious root formation may be to reduce

auxin transport.

Mutants with altered ethylene signaling or synthesis have altered free IAA levels in

hypocotyls

Ethylene has been reported to increase free IAA accumulation in root tissues

(Swarup et al., 2007). We asked if ethylene alters free IAA levels after excision in

hypocotyls. Free IAA levels were measured in root excised seedlings treated with 10 µM

ACC or 25 µM ACC for 48 hrs, as shown in Figure III-3B. There was no significant

change in the free IAA levels at either dose of ACC. We also examined the free IAA

levels in intact and excised hypocotyls of the ethylene insensitive mutant ein2-5 and

ethylene over producer mutant, eto1-1, and these levels are compared to wild type in

Figure III-3C. Root excised and intact hypocotyls of eto1-1 mutants had reduced free

IAA levels, but the difference was significant only for root excised samples (p< 0.005).

Surprisingly, ein2-5 had a similar trend in free IAA accumulation, with reduction in levels compared to wild type, with significant reduction detected only in root excised hypocotyls (p< 0.05). The reduction of free IAA levels observed in both eto1-1 and ein2-

5 may be due to the differences in size of the seedlings used in the assay. The eto1-1

mutant has smaller hypocotyls relative to wild type, while ein2-5 mutants have slightly

longer hypocotyls. This might have resulted in a greater number of eto1-1 seedlings than

ein2-5 at a similar mass of tissue. The reduction in free IAA levels in eto1-1 contrast with

previous results that ethylene increases IAA accumulation in root tips (Swarup et al.,

103 2007). Our results from hypocotyls suggest the ethylene might regulate IAA accumulation differently in stem and roots. Alternatively, there might be differences in measurement techniques, growth conditions, or tissue used in these experiments. These results indicate that the free IAA levels do not change in a consistent way with the frequency of adventitious root formation. No significant changes in free IAA levels were

observed in most of the treatments suggesting that the regulation of ethylene might be

more significant at the level of auxin transport required for adventitious root formation,

which changes in a consistent way with adventitious root phenotype.

Ethylene negatively regulates root excision induced local auxin induced gene expression

Our previous experiments have indicated that there are localized increases in

auxin accumulation driving adventitious root formation above the site of excision, as

judged by the expression of an auxin responsive promoter-GUS constuct (Sukumar and

Muday, in review). We asked if those changes in local auxin accumulation are altered in

the ethylene insensitive ein2-5 mutant, by examining the effect of 48 hrs of excision on

DR5:GUS accumulation in wild type and ein2-5, as shown in Figure III-3D. DR5:GUS

(an alternative auxin responsive reporter construct) expression above the site of excision

was enhanced in ein2-5 compared to wild type, suggesting that ethylene insensitivity

increases local auxin expression. These results are consistent with ethylene negatively

regulating auxin transport in hypocotyls, thereby reducing the auxin accumulation above

the site of excision, which drives the formation of adventitious roots.

104 Flavonoids are induced with excision and regulate auxin transport and adventitious root

formation.

Flavonoids have been shown to regulate auxin transport in roots and inflorescence

stems and to be induced with ACC treatment (Brown et al., 2001; Buer et al., 2006). We

tested whether root excision would increase flavonoid accumulation, as visualized by a

confocal laser scanning microscope after staining excised hypocotyls with DPBA

(diphenylboric acid 2-aminoethyl ester), a molecule that fluoresces upon binding to

flavonols. Figure III-4A, B show that excised hypocotyls had flavonoid accumulation at and near the site of excision, while intact hypocotyls showed minimal DPBA fluorescence. The accumulation of flavonoids after excision was limited to approximately

1-2 mm above the site of excision. This suggests that flavonoids accumulate below the

position of development of adventitious roots and at locations sufficient to drive auxin

accumulation.

To identify the mechanism for excision induced flavonoid accumulation, we used

qRT-PCR to examine the transcript levels of the gene encoding the first enzyme of

flavonoid synthesis, chalcone synthase (CHS). There was a 2.5-fold increase in CHS

message accumulation in hypocotyls relative to actin, an internal standard, at 6 hrs after

excision, as shown in Figure III-4C. This increase in CHS accumulation at 6 hrs preceded

flavonoid accumulation with excision shown at 18 hrs after root excision. Additionally,

fluorescence of a pCHS::CHS:GFP construct expressed in the tt4-11 background (Lewis

et al., in review), was found to be enhanced at 18 hrs after root excision compared to

intact seedling, as shown in Figure III-4D and E. This further confirms that accumulation

of flavonoids observed using DPBA staining is not due to increased uptake of the stain

105

A D

E

B

C F 3.5 12 Intact 3.0 10 * * Excised 2.5

transcript 8 2.0 # 6 *

CHS 1.5 4 1.0 2 0.5 excisionroots with levels, relative to time 0

Induction of adventitious of Induction 0 Hypocotyl 0.0 0hrs 6hrs WT tt4-2

106

Figure III-4: Flavonoids are induced with excision and negatively regulates adventitious root formation.

(A) Tile scan images of DPBA stained intact and root excised hypocotyls, taken using

confocal laser scanning microscope. Arrow head shows predicted position of auxin

accumulation and adventitious root formation. Scale bar is 200µm.

(B) Images of DPBA stained intact and root-excised hypocotyls captured using confocal

laser scanning microscope. Scale bar is 50 µm.

(C) Relative transcript levels of CHS in hypocotyls at the time of excision and 6 hrs later,

quantified using qRT-PCR. Values are compared to wild type by Student’s t-test. * p≤

0.01.

(D) Tile scan images or (E) high magnification image of intact and root excised

hypocotyls of pCHS::CHS:GFP transgenic seedlings captured by a confocal laser scanning microscope. Channel settings for GFP and chlorophyll were used to separate the two signals. Scale bars are 250µm (D) and 50 µm (E)

(F) Fold induction of adventitious root formation (n=22-25) in tt4-2 and wild type root excised seedlings compared to intact seedlings of respective genotype. Average ± SE are given.

* Indicates significant differences within genotypes as determined by Student’s t-test, p≤

0.01.

# Indicates significant differences between genotypes as determined by Student’s t-test . p≤ 0.01.

107 through cut ends of the stem, as staining immediately after excision is identical to

staining of intact seedlings (data not shown). The difference between DPBA and CHS

expression is in their localization pattern. While CHS is induced along the whole hypocotyl, DPBA accumulates at the site of excision, possibly because other enzymes in the flavonoid pathway have greater spatial localization. Alternatively, intermediates of

this pathway may be mobile, as reported previously (Buer et al., 2007).This suggests

flavonoid accumulation is increased upon excision through the increased synthesis of

enzyme in the flavonoid biosynthetic pathway.

Since flavonoids have been shown to regulate auxin transport and dependent

physiological processes including lateral root formation (Brown et al., 2001; Buer et al.,

2006) and flavonoid accumulation was induced upon excision, we asked if the flavonoid

deficient mutant tt4 had altered adventitious root formation with root excision. 5 day old

tt4-2 seedlings were root excised and were transferred to high light conditions and fold

induction of adventitious roots that emerged seven days later were compared to intact

seedlings within genotype, as shown in Figure III-4F. tt4-2 mutants showed significant 6-

fold induction of adventitious roots (p< 0.005) upon excision as compared to intact

seedlings. This induction is less than the 10-fold induction seen in wild type. This

suggests that localized flavonoid synthesis is part of the mechanism by which excision

enhances adventitious root formation.

Additionally, we asked if tt4-2 mutants have altered hypocotyl auxin transport

with root excision, when grown under these conditions. Basipetal IAA transport was

measured in hypocotyls of intact and root excised wild type and tt4-2, 48 hrs after

excision. The percentage increase in transport due to excision was compared to intact

108

A C 2.5 250 Intact 0hrs 2.0 200 * Excised 6hrs * 150 1.5 # 100 1.0 transcript levelstranscript 50 0.5 relative to wild type % of hypocotyl IAA hypocotyl % of CHS 0 transport relative to intact 0.0 WT tt4-2 WT eto1-1 B D 18 Col 120 16 Control tt4-2 25µM ACC 14 # 100 *# 12 80 10 * 8 60 6 40 4 20

2 roots % of control 0 Free IAAFree levels, ng/gFW Number of adventitious Number of 0 Intact Excised WT tt4-2 48 hrs 48 hrs

Figure III-5: Ethylene induces flavonoids in hypocotyls and effect of ethylene on

adventitious root formation is partially dependent on flavonoids.

(A) Basipetal hypocotyl IAA transport (n=26-29) in tt4-2 and wild type root excised

seedlings compared to intact seedlings of respective genotype. Average ± SE are given.

* Indicates significant differences within genotypes as determined by Student’s t-test, p≤

0.01.

# Indicates significant differences between genotypes as determined by Student’s t-test . p≤ 0.01.

109 (B) Free IAA levels quantified using GC-Mass Spec in wild type and tt4-2 seedlings at the time of excision, and 48 hrs in intact and excised hypocotyls. Average ± SE are given.

Values are compared to untreated (#) by Student’s t-test. p≤ 0.05.

(C) Relative transcript levels of CHS in hypocotyls of wild type and eto1-1 at the time of excision and 6 hrs later, quantified using qRT-PCR. Values are compared to wild type by

Student’s t-test. * p≤ 0.05.

(D) Adventitious root formation in flavonoid deficient mutant tt4-2 with or without 25

µM ACC treatment, quantified 7 days after root excision. Average ± SE of 31-32 seedlings are given. Values are compared to untreated controls by Student’s t test.

* Indicates significant differences within genotypes as determined by Student’s t-test, p≤

0.05.

# Indicates significant differences between genotypes as determined Student’s t-test p≤

0.005.

110 seedlings within genotype as shown in Figure III-5A. Even though there was a significantly greater level of basipetal IAA transport in intact hypocotyls of tt4-2 compared to wild type (data not shown), the root excised hypocotyls of tt4-2 did not exhibit the same magnitude of increase in IAA transport after excision as observed in wild type (p< 0.005). This result is consistent with the weaker effect of root excision on adventitious root formation found in tt4-2, as compared to wild-type. These results suggest a model by which localized flavonoid accumulation blocks auxin efflux from hypocotyls driving adventitious root formation above the point of excision.

To test if flavonoids alter auxin accumulation in hypocotyls, we measured free

IAA levels in tt4-2 in intact and excised hypocotyls 48 hrs after excision, as shown in

Figure III-5B. There was no difference in the levels of free IAA in tt4-2 compared to wild type, suggesting that flavonoids may not affect the overall free IAA levels. Although there was a significant increase in free IAA levels in root excised hypocotyls of tt4-2 compared to intact tt4-2 (p< 0.05), these results do not indicate that flavonoids lead to global changes in free IAA in hypocotyls, but rather locally inhibit IAA transport leading to local sites of auxin accumulation.

The ethylene alters flavonoid accumulation after excision

Ethylene increases flavonoid synthesis through induction of transcription of genes encoding flavonoid enzymes (Lewis et al., in review). Since we saw that ethylene and flavonoids are induced with excision, we asked if flavonoid accumulation is ethylene dependent. We examined CHS transcript accumulation in the eto1-1 mutant using qRT-

PCR. The accumulation of CHS relative to actin was compared in excised seedlings, 6

111 hrs after excision to excised seedlings at 0 time point, as shown in Figure III-5C. eto1-1 had increased CHS accumulation, indicating that increased ethylene production may increase flavonoid biosynthetic activity.

Ethylene and flavonoids interact in modulating root growth and gravitropism

(Buer et al., 2006). Therefore we asked if flavonoids are necessary for ethylene inhibition of adventitious roots, by examining the effect of ACC treatment on adventitious root formation in flavonoid deficient tt4-2 mutants, as shown in Figure III-

5D. Although ACC treatment reduced slightly, but significantly, the formation of adventitious roots in root excised tt4-2 hypocotyls (p< 0.05), the magnitude of reduction was less compared to the ACC-induced reduction in wild type hypocotyls (p< 0.005).

This suggests that tt4-2 is less sensitive to the inhibitory effect of ACC on adventitious root formation and that ACC may act in part through flavonoid synthesis.

Ethylene decreases ABCB19 protein accumulation

Our previous research has shown that excision increases PIN1 transcription, and

pin1-1 mutants have reduced number of adventitious roots, consistent with PIN1 having a

role in mediating auxin transport required for adventitious root formation (Sukumar and

Muday, in review). We asked if this enhancement of PIN1 transcription is altered in

ethylene mutants to see if that is one cause of altered auxin transport and adventitious

root formation. Transcript levels of PIN1 relative to an internal standard actin, were

measured in eto1-1 seedlings, 6 hrs after excision and compared to wild type, as shown in

supplemental Figure III-S2. There was no difference in the relative transcript levels of

PIN1 between eto1-1 and col. This suggests that ethylene does not affect auxin transport

112

S2 2.5 0hrs 2.0 6hrs 1.5

transcript levelstranscript 1.0

PIN1 0.5

0.0 Col eto1-1

Relative

Supplemental Figure III-2: Relative transcript levels of CHS in Col and eto1-1 seedlings measured using qRT-PCR

113 through altering transcription of PIN1.

abcb19 mutants have reduced adventitious root formation and

pABCB19::ABCB19:GFP fusion protein accumulation has been shown to increase with root excision (Sukumar and Muday, in review). We asked if abcb19 mutants are responsive to ethylene induced reduction of adventitious root formation, to test if ethylene might affect auxin transport or accumulation through ABCB19. Adventitious roots formed 7 days after excision were quantified in abcb19 mutants treated with and without ACC and were compared to wild type, as shown in Figure III-6A. abcb19 mutants were insensitive to ethylene as there was no further reduction in number of adventitious roots formed with ACC treatment. This suggests that the effect of ACC on root formation is ABCB19-dependent.

Additionally we tested if ethylene alters pABCB19::ABCB19:GFP protein accumulation, as our previous experiments have shown that fluorescence of an

ABCB19:GFP fusion protein is enhanced upon excision (Sukumar and Muday, in review).

We examined the effect of ACC treatment on pABCB19::ABCB19:GFP fluorescence using confocal microscopy, as shown in Figure III-6B. ACC treatment resulted in significant 30% reduction in pABCB19::ABCB19:GFP fluorescence, 3 days after root excision (p< 0.05). Furthermore, there was no change in the fluorescence level of transcriptional construct pABCB19::GFP with and without ACC treatment, suggesting that ethylene might not affect transcription of ABCB19 consistent with previous experiments that excision effects on ABCB19 are post transcriptional (data not shown)

(Sukumar and Muday, in review). These results suggest that ethylene reduces ABCB19 protein stability, indicating that ethylene reduction of auxin transport might act through

114

A

7

6 Control 25µM ACC 5 4 * # 3

2

1

0

Number of adventitious roots adventitious Number of Col abcb19 B

C 16 14 * Intact 12 Excised 10 8 6 4 # 2 * roots with excision with roots 0 Induction of adventitious of Induction WT abcb19

115 Figure III-6: Ethylene regulation of auxin transport proteins mediating auxin transport required for adventitious root formation.

(A) Adventitious roots formed in Col and abcb19 seedlings treated with 25µM ACC, quantified 7 days after root excision. Average ± SE of 31-45 seedlings are given. Values are compared using Student’s t test.

* Indicates significant differences within genotypes as determined by Student’s t-test, p≤

0.005.

# Indicates significant differences between genotypes as determined Student’s t-test p≤

0.005.

(B) Images of pABCB19::ABCB19:GFP with or without 25µM ACC treatment, taken using confocal microscope after lambda scanning and linear unmixing. Scale bar is 50

µm. Numbers on the image correspond to Average ± SE of relative GFP fluorescence.

(C) Fold induction of adventitious root formation (n=41-60) in abcb19 and wild type compared to intact seedlings of respective genotype. Average ± SE are given.

* Indicates significant differences within genotypes as determined by Student’s t-test, p≤

0.001.

# Indicates significant differences between genotypes as determined Student’s t-test p≤

0.001.

116 reducing ABCB19 accumulation.

Furthermore, similar to tt4-2 mutants, we find that abcb19 mutants exhibit reduced induction of adventitious root through root excision, as shown in Figure III-6C.

While wild type had a 12-fold increase in adventitious root formation, abcb19 had significantly lower 2-fold induction with root excision (p< 0.01). This effect of the abcb19 mutation is greater in magnitude than in the effect of tt4-2 on root excision induced adventitious roots. These results indicate that change in ABCB19 protein and flavonoid accumulation may account for the ethylene effects on auxin transport and adventitious root formation.

117 Discussion

Although ethylene regulates many aspects of , recent

experiments have demonstrated a role for this hormone in controlling root branching. In particular, genetic approaches have been used to show that ethylene negatively regulates lateral root development in Arabidopsis and tomato (Negi et al., 2010; Negi et al., 2008).

Few studies have utilized the tomato ethylene signaling mutant NR to determine that

intrinsic ethylene positively regulates adventitious root formation in tomato (Clark et al.,

1999; Kim et al., 2008). We have identified an opposite and inhibitory role of ethylene in

adventitious root formation in Arabidopsis and have used the genetic tools available in

this species to identify the mechanism by which ethylene modulates this process.

We examined the role of ethylene in regulating adventitious root formation in

Arabidopsis, by using low light grown seedlings with elongated hypocotyls, and inducing

adventitious root formation through root excision, a procedure previously shown to

enhance root formation 10-fold over intact hypocotyls (Sukumar and Muday, in review).

ACC treatment and the eto1-1 mutation reduced the formation of adventitious roots,

while the ethylene insensitive mutants, ein2-5 and etr1-1 had enhanced formation of

adventitious roots. All these changes affected the number of adventitious roots formed

but did not alter the longitudinal position of root formation. Consistent with ethylene not

having an effect on position of formation of adventitious roots, canthardin induced delocalization of adventitious roots were found to be independent of alteration in ethylene

signaling and synthesis. These results suggest that ethylene negatively regulates the

formation of adventitious roots in Arabidopsis.

118 Ethylene consistently negatively regulates lateral root development in tomato and

Arabidopsis (Negi et al., 2008; Ivanchenko et al., 2008; Negi et al., 2010), but has variable effect on adventitious root formation in between species (Roy et al., 1972;

Coleman et al., 1980; Nordstrom and Eliasson, 1984; reviwed in De-Klerk et al., 1999;

Clark et al., 1999; Kim et al., 2008). In tomato, ACC treatment enhances adventitious root formation, while an ethylene insensitive NR mutation reduces the formation of adventitious roots (Negi et al., 2010), opposite to the effect of ethylene in Arabidopsis.

The positive effect of ethylene on adventitious root development has also been found in other species of plants such as Rumex, apple, and Vigna (reviewed in De-Klerk et al.,

1999; Riov and Yang, 1989; Visser et al., 1996). The genetic basis of these species differences in effect of ethylene may be tied to differences in plant shoot architecture or other aspects of their growth and developmental programs or environmental responses.

Previous research has revealed a positive role for auxin during the development of adventitious roots in Arabidopsis, as the ago (argonaute) and sur (superroot) mutants have altered adventitious root formation caused by altered auxin signaling and synthesis

(Sorin et al., 2005; Gutierrez et al., 2009). In particular, root excision enhances auxin transport and local auxin accumulation which drives adventitious root formation

(Sukumar and Muday, in review). Previous experiments indicate that ethylene regulates auxin transport and signaling (Rahman et al., 2002; Buer et al., 2006; Muday et al., 2006;

Negi et al., 2008). We examined the effect of ethylene on auxin transport and local auxin accumulation and found that both were reduced by ethylene. Ethylene insensitive mutants have enhanced auxin transport and local auxin accumulation above the site of excision, while ethylene overproduction in the eto1-1 mutant resulted in reduced auxin

119 transport. These results suggest that ethylene alters adventitious root in Arabidopsis

formation through modulation of auxin transport and accumulation.

Involvement of auxin-ethylene crosstalk in adventitious root formation has been explored in agriculturally important species such as tomato, with results that differ from

Arabidopsis in several ways. In tomato, the ethylene insensitive mutation, NR, and silver

nitrate treatments that confer ethylene insensitivity result in enhanced transport, while

ACC treatments result in reduction of auxin transport in hypocotyls (Negi et al., 2010),

similar to Arabidopsis. This is consistent with the negative effect of ACC on auxin

transport, found in pea stems (Suttle, 1988). No overall effect on auxin accumulation was

found in tomato hypocotyls with ACC treatment, similar to Arabidopsis. Moreover

ethylene insensitivity reduced the ability of plants to respond to exogenous IAA, with

these mutants never forming as many adventitious roots as wild type. However, ethylene

modulated increases in auxin sensitivity were found to regulate adventitious root

formation in Rumex under flooded conditions (Visser et al., 1996). This effect of

ethylene was reduced if the plants were treated with NPA, an auxin transport inhibitor,

suggesting a positive relation between ethylene and auxin transport in this species (Visser

et al., 1996). Conversely, auxin induced ethylene synthesis was found to enhance

adventitious root formation in Vigna (Riov and Yang, 1989). These results indicate that

auxin-ethylene cross talk follows a complex pattern with mutual regulation and in a

species specific manner.

We explored the mechanisms by which ethylene might regulate auxin transport.

The ABCB19 auxin efflux carrier was shown to be required for both the inhibition of

adventitious root formation by ACC and the stimulation of root formation by shoot

120 excision. An pABCB19::ABCB19:GFP fusion protein was found to accumulate at reduced levels after ACC treatment. This suggests that one possible mechanism by which ethylene might alter auxin transport and subsequent local auxin accumulation required for adventitious root formation is through modulating accumulation of the auxin transport protein ABCB19. Additionally, root excision was found to enhance localized accumulation of flavonoids at and above the site of excision, at positions of the local

accumulation of auxin and the formation of adventitious roots. This indicates that

flavonoid accumulation at these positions might block auxin movement, resulting in

accumulation of auxin. The absence of flavonoids in tt4-2 was associated with reduced

sensitivity to excision enhanced adventitious roots and auxin transport. The adventitious

root formation in tt4-2 was found to be partially ethylene insensitive. In contrast, eto1-1,

had enhanced expression of the flavonoid biosynthetic enzyme, CHS, and reduced

formation of adventitious roots, suggesting that global and local flavonoid accumulation

along the hypocotyls may have different effects. Consistent with this, tt4-2 hypocotyls

have enhanced adventitious root formation, possibly due to its enhanced auxin transport,

compared to wild type seedlings. This suggests flavonoids can differentially affect the

development of adventitious roots, and ethylene might be involved in the regulating flavonoid accumulation.

An interesting possibility is that flavonoids act on ABCB19. Consistent with this idea that flavonoids might interact with ABCB19, several studies have examined the interaction of auxin efflux proteins with flavonoids. tt4 mutants have defective localization of auxin transport protein PIN1 (Peer et al., 2004). Additionally, the faster gravity response in abcb4 mutant was found to be epistatic to the delayed gravity

121 response in the tt4 mutant, suggesting that flavonoids might act on ABCB4 (Lewis et al.,

2007). In HeLa expressing AtPGP1 (ABCB1), quercetin, one of the active

flavonoids known to regulate auxin transport, was found to reduce IAA efflux (Geisler et

al., 2005). These results provide evidence that flavonoids can interact with auxin

transport proteins, especially on ABCBs. We have found that abcb19 mutants have insensitivity to excision induced adventitious root formation similar to tt4-2. Additionally,

adventitious root formation in the abcb19 mutant is insensitive to ACC. This indicates a possible mechanism by which ethylene regulated flavonoids interact with ABCB19, in turn modulating auxin transport necessary for adventitious root formation.

Together, our results implicate ethylene-auxin crosstalk in regulating adventitious root formation in Arabidopsis. Ethylene negatively regulates auxin transport, and local auxin accumulation, both of which mediate formation of adventitious roots. The ability of

IAA to induce adventitious roots was found to be ethylene sensitive, with ACC treatments reducing, while ethylene insensitivity enhancing IAA induction of adventitious roots. Moreover, ethylene reduced ABCB19 accumulation, and increased flavonoid synthesis, uncovering two mechanisms by which ethylene negatively regulates

auxin transport in hypocotyls. Together these results identify hormonal cross talk which

regulates adventitious root formation with ethylene inhibiting auxin transport and thereby reducing the formation of adventitious roots.

122 Methods

Plant materials and chemicals

Columbia, and Wassilewskija ecotypes were used in this study. Seeds of abcb19, pABCB19::GFP, and pABCB19::ABCB19:GFP were kindly provided by Guosheng Wu and Edgar Spalding (Wu et al., 2007). ein2-5 DR5:GUS, and eto1-1 were provided by

Jose Alonso (Stepanova et al., 2007). ctr1-1 was provided by Joe Kieber (Kieber et al.,

1993). pCHS::CHS:GFP was provided by Brenda Winkel (Lewis et al., in review). All the other mutants were received from the ABRC stock center.

IAA was purchased from MP Biochemicals (Solon, Ohio). [3H]IAA (24 and 20 Ci mmol–1) was purchased from Amersham or American Radiolabeled Chemicals (St Louis,

MO). NPA was purchased from Chemical Services (West Chester, PA). 5 Bromo-4 chloro-3 indoyl-β-D-Glu UA cyclohexylamine salt was purchased from Gold biotechnology (St Louis, MO). RNeasy kit for isolation of RNA was purchased from

Qiagen (Valencia, CA). Components of RNAse treatment, and cDNA synthesis were purchased from Invitrogen (Carlsbad, CA). Reagents for DNAse treatment was purchased from Promega (Madison, Wisconsin). SYBRgreen reagent was purchased from Applied

Biosystems (Foster City, CA). All other chemicals were purchased from Sigma (St Louis,

MO).

Plant growth conditions and quantification of adventitious roots

Seeds were sterilized by soaking in 95% ethanol (v/v) and 20% bleach (v/v) with

10% Triton X-100(v/v) for 5 min each and then washed five times with sterilized water.

Seeds were then plated in sterile agar medium containing 0.8% (w/v) Type M agar (A-

123 4800, Sigma), 1× MS nutrients (macro and micro salts), vitamins (1 µg⋅mL−1 thiamine, 1

µg⋅mL−1 pyridoxine HCl, and 0.5 µg⋅mL−1 nicotinic acid), 1.5% (w/v) sucrose, 0.05%

(w/v) MES, with pH adjusted to 5.8 with 1N KOH before autoclaving. Plates were placed

in racks in a vertical orientation under light intensity of 3-5µmol m–2 s–1 for 5 days to

induce hypocotyl elongation.

Five day old low light grown seedlings were used in the experiments with or without excision using Neuro clipper scissors (Fine Science Tools) at a position 5-7.5 mm from shoot apex excision. They were allowed to grow for 7 more days under a light intensity of 85-100 µmol m–2 s–1. Adventitious roots were quantified on the 7th day unless

otherwise indicated using a dissecting microscope.

Applications of IAA, IBA, ACC, and canthardin

Stocks of IAA and IBA were made in ethanol while canthardin was made in

DMSO at 10 mM. ACC was dissolved in water to make a 10 mM stock. For global

treatment, chemicals were added to the agar growth medium cooled to 50o C at indicated

concentrations. All experiments involving IAA and IBA treatments were placed under

fluorescent lights with yellow filters to prevent white light induced degradation of IAA

(Stasinopoulos and Hangarter, 1989). Observations on position and number of emerged

adventitious roots were performed after 7 days using a dissecting microscope.

β –Glucuronidase staining

DR5:GUS transgenic seedlings were incubated in 2 mM GUS substrate (100 mM

sodium phosphate buffer, 0.5% Triton X, 2 mM X-gluc salt, 0.5 mM ferricyanide and 0.5

124 mM ferrocyanide) at 37o C for overnight. Samples were then washed with 100 mM

sodium phosphate buffer, pH 7 and stored in 95% ethanol. The samples were fixed and

cleared as mentioned below, and analyzed for localization of GUS staining using an Epi-

Fluorescent Leica MZ16 FA stereomicroscope.

Fixing and clearing

Seedlings were fixed in a solution containing 10% (v/v) formaldehyde, 5% (v/v)

acetic acid and 50% (v/v) ethanol, overnight at 4 0C. Then clearing was performed using

chloral hydrate:glycerol:water solution (8:1:2, w:v:v), at room temperature (Fukaki et al.,

1998). Cleared seedlings were mounted in 95% ethanol and visualized using an Epi-

Fluorescent Leica MZ16 FA stereomicroscope.

DPBA staining

Root excised or intact seedlings were incubated for 7 min in a solution with

0.25% DPBA (w/v) and 0.005% TritonX-100 (v/v). The seedlings were then washed with

deionized water for an additional 7 min, were mounted in deionized water and analyzed

using Zeiss LSM710 Meta fluorescence laser scanning confocal microscope using two

channels; 460-504 nm (to capture Kaempferol fluorescence), 577-619 nm (to capture

quercetin fluorescence) with laser at 458 nm (Lewis et al., in review). Tiled images were

taken with three vertical and seven horizontal sections using the above mentioned

channel settings. All pictures within an experiment were taken under similar settings.

pABCB19::ABCB19:GFP imaging and quantification

125 GFP fluorescence was observed using Zeiss LSM710 Meta fluorescence laser

scanning confocal microscope using lambda scanning at 494-649nm, using 488nm laser,

with samples mounted in deionized water. Chloroplast, and GFP signals were separated

using linear unmixing using reference spectra. Quantification of GFP signals were

performed using linear profiles through the longitudinal sides of the cells using the Zeiss

Zen software. All pictures within an experiment were taken under similar settings, unless

indicated otherwise.

pCHS::CHS:GFP imaging

Low light grown transgenic seedlings were transferred to high light conditions

with or without excision for 18 hrs. GFP fluorescence was observed using Zeiss LSM710

laser scanning confocal microscope using channel setting with 488 nm laser, with

samples mounted in deionized water. Two channels, 493-556nm and 637-721 nm, were

used to separate GFP, and chloroplast signals, respectively. All pictures within an

experiment were taken under identical laser, gain, and pinhole settings.

Auxin transport and free IAA measurements in hypocotyl

Auxin transport measurements in the hypocotyls were performed by modifying a

previously published method (reviewed in Lewis and Muday, 2009). 5 day old low light

grown seedlings; either intact or excised, were transferred to control plates and their

shoot apex were removed. An agar cylinder or agar droplets with tritiated IAA with

approximate concentration of 100 nM was applied at the shoot end and incubated in the

dark for 3 hrs. 3mm sections were removed from the basal end from the excised

126 hypocotyls, after 3 hrs and were used for quantification using a Beckman LS 6500

scintillation counter.

For quantification of free IAA levels, 5 day old low light seedlings were transferred to high light conditions with or without excision, and hypocotyl tissues were harvested at indicated time points and frozen in liquid nitrogen. About 50-80 mg of frozen tissues were homogenized using 150µl of homogenization buffer (65%

13 isopropanol, 35% 0.2 M imidazole, pH 7), incubated with internal standard ( C6)- IAA, followed by centrifugation at 10,000 g for 8 min. Free IAA was extracted by running through two automated successive columns followed by methylation, drying and redissolving in ethyl acetate (Barkwai et al, 2008). Quantification was done using GC-

SIM-MS through isotope dilution analysis and values are reported relative to fresh weight

(ng/g).

RNA extraction and Quantitative Real time PCR measurements

Low light grown seedlings were transferred to high light conditions for 6hrs.

Hypocotyl tissues (for Figure 4C) or whole seedlings (for Figure 5D) were frozen in

liquid nitrogen. As controls, intact seedlings were excised and were frozen immediately.

Total RNA was isolated using Qiagen plant RNeasy kit, after homogenization of tissue

samples with a Power-drill equipped with a disposable mortar. DNAase treatments were

performed and RNA samples were equilibrated. cDNA reactions were performed

followed by RNAse treatment. cDNA samples were run in 96 well plate in a real time

PCR machine (Applied Biosystems 7600-fast thermal cycler) using target specific

primers, deionized water, and SYBR green reagent. Transcript levels relative to actin

127 were calculated using a standard curve. The primers used were CHS-Forward:

CGTGTTGAGCGAGTATGGAAAC, Reverse:

TGACTTCCTCCTCCTCATCTCGTCTAGT, ABCB19- Forward:

CAGGAAATGGTTGGTACTCGAGAT, Reverse: GAATGGCTCAAACGGGTT.

PIN1-Forward: ATCACCTGGTCCCTCATTTC, Reverse:

CCATGAACAACCCAAGACTG. Actin-Forward:

TGAGAGATTCAGATGCCCAGAA, Reverse: GCAGCTTCCATTCCCACAA.

Acknowledgements We appreciate Sangeeta Negi and Hanya Chrispeels for their thoughtful comments. We

thank Jose Alonso, Joe Kieber, Brenda Winkel, and Edgar Spalding for sharing mutant

and transgenic Arabidopsis seeds. We appreciate the microscopy assistance of Anita

McCauley. We appreciate the assistance of Jerry Cohen and Xing Liu with free IAA measurements.

128 Literature cited

Alonso JM, Hirayama T, Roman G, Nourizadeh S, Ecker JR (1999) EIN2, a

bifunctional transducer of ethylene and stress responses in Arabidopsis. Science

284: 2148-2152

Argueso CT, Hansen M, Kieber JJ (2007) Regulation of ethylene biosynthesis. Journal

of Plant Growth Regulation 26: 92-105

Bleecker A, Estelle M, Magidin M, Somerville C, Kende H (1988) Insensitivity to

ethylene conferred by a dominant mutation in Arabidopsis thaliana. Science 241:

1086-1089

Bleecker AB, Estelle MA, Somerville C, Kende H (1988) Insensitivity to Ethylene

Conferred by a Dominant Mutation in Arabidopsis-Thaliana. Science 241: 1086-

1089

Bleecker AB, Kende H (2000) Ethylene: A gaseous signal molecule in plants. Annual

Review of Cell and Developmental Biology 16: 1-+

Brown D, Rashotte A, Murphy A, Tague B, Peer W, Taiz L, Muday G (2001)

Flavonoids act as negative regulators of auxin transport in vivo in Arabidopsis

thaliana. Plant Physiol 126: 524-535

Buer CS, Muday GK (2004) The transparent testa4 mutation prevents flavonoid

synthesis and alters auxin transport and the response of Arabidopsis roots to

gravity and light. Plant Cell 16: 1191-1205

Buer CS, Muday GK, Djordjevic MA (2007) Flavonoids are differentially taken up and

transported long distances in Arabidopsis. Plant Physiology 145: 478-490

129 Buer CS, Sukumar P, Muday GK (2006) Ethylene modulates flavonoid accumulation

and gravitropic responses in roots of Arabidopsis. Plant Physiology 140: 1384-

1396

Chae HS, Faure F, Kieber JJ (2003) The eto1, eto2, and eto3 mutations and cytokinin

treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability

of ACS protein. Plant Cell 15: 545-559

Chao QM, Rothenberg M, Solano R, Roman G, Terzaghi W, Ecker JR (1997)

Activation of the ethylene gas response pathway in Arabidopsis by the nuclear

protein ETHYLENE-INSENSITIVE3 and related proteins. Cell 89: 1133-1144

Clark DG, Gubrium EK, Barrett JE, Nell TA, Klee HJ (1999) Root formation in

ethylene-insensitive plants. Plant Physiol 121: 53-60

Coleman W, Huxter T, Reid D, Thrope T (1980) Ethylene as an endogenous inhibitor

of root regeneration in tomato leaf disc cultures in vitro. Physiol Plant 48: 519-

525

Collett CE, Harberd NP, Leyser O (2000) Hormonal interactions in the control of

Arabidopsis hypocotyl elongation. Plant Physiology 124: 553-561

De-Klerk G, Krieken W, DeJong J (1999) The formation of adventitious roots: New

concepts, new possibilities. In Vitro Cell Dev Biol-Plant 35: 189-199

Fukaki H, Wysocka-Diller J, Kato T, Fujisawa H, Benfey PN, Tasaka M (1998)

Genetic evidence that the endodermis is essential for shoot gravitropism in

Arabidopsis thaliana. Plant J 14: 425-430

Geisler M, Blakeslee JJ, Bouchard R, Lee OR, Vincenzetti V, Bandyopadhyay A,

Titapiwatanakun B, Peer WA, Bailly A, Richards EL, Ejenda KFK, Smith

130 AP, Baroux C, Grossniklaus U, Muller A, Hrycyna CA, Dudler R, Murphy

AS, Martinoia E (2005) Cellular efflux of auxin catalyzed by the Arabidopsis

MDR/PGP transporter AtPGP1. Plant Journal 44: 179-194

Gutierrez L, Bussell JD, Pacurar DI, Schwambach J, Pacurar M, Bellini C (2009)

Phenotypic Plasticity of Adventitious Rooting in Arabidopsis Is Controlled by

Complex Regulation of AUXIN RESPONSE FACTOR Transcripts and

MicroRNA Abundance. Plant Cell 21: 3119-3132

Ivanchenko MG, Muday GK, Dubrovsky JG (2008) Ethylene-auxin interactions

regulate lateral root initiation and emergence in Arabidopsis thaliana. Plant J 55:

335-347

Kieber JJ (1997) The ethylene signal transduction pathway in Arabidopsis. Journal of

Experimental Botany 48: 211-218

Kieber JJ, Rothenberg M, Roman G, Feldmann KA, Ecker JR (1993) CTR1, a

negative regulator of the ethylene response pathway in Arabidopsis, encodes a

member of the Raf family of protein kinases. Cell 72: 427-441

Kim HJ, Lynch JP, Brown KM (2008) Ethylene insensitivity impedes a subset of

responses to phosphorus deficiency in tomato and petunia. Plant Cell Environ 31:

1744-1755

Knee E, Hangarter R, Knee M (2000) Interactions of light and ethylene in hypocotyl

hook maintenance in Arabidopsis thaliana seedlings. Physiol. Plant.: 208-215

Lewis DR, Miller ND, Splitt BL, Wu GS, Spalding EP (2007) Separating the roles of

acropetal and basipetal auxin transport on gravitropism with mutations in two

131 Arabidopsis Multidrug Resistance-Like ABC transporter genes. Plant Cell 19:

1838-1850

Lewis DR, Muday GK (2009) Measurement of auxin transport in Arabidopsis thaliana.

Nat Protoc 4: 437-451

Lewis DR, Ramirez MV, Miller ND, Winkel BSJ, Muday GK (in review) Auxin and

ethylene induce distinct flavonol accumulation patterns through independent

transcriptional networks Plant Cell

Li S, Xue L, Xu S, Feng H, An L (2009) Mediators, Genes and signaling in

Adventitious rooting. Bot.Rev 75: 230-247

Muday GK, Brady SR, Argueso C, Deruere J, Kieber JJ, DeLong A (2006) RCN1-

regulated phosphatase activity and EIN2 modulate hypocotyl gravitropism by a

mechanism that does not require ethylene signaling. Plant Physiol 141: 1617-

1629

Negi S, Ivanchenko MG, Muday GK (2008) Ethylene regulates lateral root formation

and auxin transport in Arabidopsis thaliana. Plant J 55: 175-187

Negi S, Sukumar P, Liu X, Cohen JD, Muday GK (2010) Genetic dissection of the

role of ethylene in regulating auxin-dependent lateral and adventitious root

formation in tomato. Plant J 61: 3-15

Nordstrom A-C, Eliasson L (1984) Regulation of root formation by auxin-ethylene

interaction in pea stem cuttings. Physiol Plant 61: 298-302

Peer WA, Bandyopadhyay A, Blakeslee JJ, Makam SI, Chen RJ, Masson PH,

Murphy AS (2004) Variation in expression and protein localization of the PIN

132 family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin

transport in Arabidopsis thaliana. Plant Cell 16: 1898-1911

Potuschak T, Lechner E, Parmentier Y, Yanagisawa S, Grava S, Koncz C, Genschik

P (2003) EIN3-dependent regulation of plant ethylene hormone signaling by two

Arabidopsis F box proteins: EBF1 and EBF2. Cell 115: 679-689

Poupart J, Rashotte AM, Muday GK, Waddell CS (2005) The rib1 mutant of

Arabidopsis has alterations in indole-3-butyric acid transport, hypocotyl

elongation, and root architecture. Plant Physiology 139: 1460-1471

Rahman A, Amakawa T, Goto N, Tsurumi S (2001) Auxin is a positive regulator for

ethylene-mediated response in the growth of Arabidopsis roots. Plant Cell Physiol

42: 301-307

Rahman A, Hosokawa S, Oono Y, Amakawa T, Goto N, Tsurumi S (2002) Auxin and

ethylene response interactions during Arabidopsis root hair development dissected

by auxin influx modulators. Plant Physiol 130: 1908-1917

Rashotte AM, Poupart J, Waddell CS, Muday GK (2005) Transport of the two natural

auxins, indole-3-butyric acid and indole-3-acetic acid, in Arabidopsis (vol 133, pg

761, 2005). Plant Physiology 139: 559-559

Riov J, Yang S (1989) Ethylene and Auxin-ethylene interaction in adventiitous root

formation in Mung bean (Vigna radiata) cuttings. Journal of Plant Growth

Regulation 8: 131-141

Roy B, Basu R, Bose T (1972) Interaction of auxins with growth-retarding, -inhibiting

and ethylene-producing chemicals in rooting of cuttings. Plant Cell Physiol 13:

1123-1127

133 Ruzicka K, Ljung K, Vanneste S, Podhorska R, Beeckman T, Friml J, Benkova E

(2007) Ethylene regulates root growth through effects on auxin biosynthesis and

transport-dependent auxin distribution. Plant Cell 19: 2197-2212

Smalle J, Haegman M, Kurepa J, VanMontagu M, VanderStraeten D (1997)

Ethylene can stimulate Arabidopsis hypocotyl elongation in the light. Proceedings

of the National Academy of Sciences of the United States of America 94: 2756-

2761

Sorin C, Bussell JD, Camus I, Ljung K, Kowalczyk M, Geiss G, McKhann H,

Garcion C, Vaucheret H, Sandberg G, Bellini C (2005) Auxin and light control

of adventitious rooting in Arabidopsis require ARGONAUTE1. Plant Cell 17:

1343-1359

Stasinopoulos TC, Hangarter RP (1989) Preventing photochemistry in culture media

by long-pass light filters alters growth of cultured tissues. Plant Physiol 93: 1365-

1369

Stepanova AN, Hoyt JM, Hamilton AA, Alonso JM (2005) A link between ethylene

and auxin uncovered by the characterization of two root-specific ethylene-

insensitive mutants in Arabidopsis. Plant Cell 17: 2230-2242

Stepanova AN, Yun J, Likhacheva AV, Alonso JM (2007) Multilevel interactions

between ethylene and auxin in Arabidopsis roots. Plant Cell 19: 2169-2185

Strader LC, Bartel B (2009) The Arabidopsis PLEIOTROPIC DRUG

RESISTANCE8/ABCG36 ATP Binding Cassette Transporter Modulates

Sensitivity to the Auxin Precursor Indole-3-Butyric Acid. Plant Cell 21: 1992-

2007

134 Sukumar P, Muday GK (in review) Polar auxin transport mediated by ABCB19 and

PIN1 regulate adventitious root formation in Arabidopsis. Plant Physiol

Suttle JC (1988) Effect of ethylene treatment on polar IAA transport, net IAA uptake

and specific binding of N-1-naphthylphthalamic acid in tissues and microsomes

isolated from etiolated pea epicotyls. Plant Physiol. 88: 795-799

Swarup R, Perry P, Hagenbeek D, Van Der Straeten D, Beemster GT, Sandberg G,

Bhalerao R, Ljung K, Bennett MJ (2007) Ethylene upregulates auxin

biosynthesis in Arabidopsis seedlings to enhance inhibition of root cell elongation.

Plant Cell 19: 2186-2196

Visser E, Cohen JD, Barendse G, Blom C, Voesenek L (1996) An Ethylene-Mediated

Increase in Sensitivity to Auxin Induces Adventitious Root Formation in Flooded

Rumex palustris Sm. Plant Physiol 112: 1687-1692

Woodward AW, Bartel B (2005) Auxin: Regulation, action, and interaction. Annals of

Botany 95: 707-735

Wu G, Lewis DR, Spalding EP (2007) Mutations in Arabidopsis multidrug resistance-

like ABC transporters separate the roles of acropetal and basipetal auxin transport

in lateral root development. Plant Cell 19: 1826-1837

135 CHAPTER IV

GENETIC DISSECTION OF THE ROLE OF ETHYLENE IN REGULATING AUXIN-

DEPENDENT LATERAL AND ADVENTITIOUS ROOT FORMATION IN TOMATO

Negi S., Sukumar P., Liu X., Cohen J.D., Muday G.K.

The following manuscript was published in Plant Journal, volume 61, pages 3-15, 2010

and is reprinted with permission (license number 2391251257171). Stylistic variations are due to the requirements of the journal. Negi S., and Sukumar P. have co-first authorship and Muday G.K. is the corresponding author.

136 Abstract

In this study we investigated the role of ethylene in lateral and adventitious root formation in tomato (Solanum lycopersicum) using mutants isolated for altered ethylene signaling and fruit ripening. Mutations that block ethylene responses and delay ripening:

Nr (Never ripe), gr (green ripe), nor (non ripening), and rin (ripening inhibitor) have enhanced lateral root formation. In contrast, the epi (epinastic) mutant, which has elevated ethylene and constitutive ethylene signaling in some tissues, or treatment with the ethylene precursor (ACC), reduces lateral root formation. ACC treatment inhibits initiation and elongation of lateral roots, except in the Nr genotype. Root basipetal and acropetal IAA transport increase with ACC treatments or in the epi mutant, while in the

Nr mutant there is less auxin transport than wild type and transport is insensitive to ACC.

In contrast, the process of adventitious root formation shows the opposite response to ethylene, with ACC treatment and the epi mutation increasing adventitious root formation and the Nr mutation reducing the numbers of adventitious roots. In hypocotyls, ACC treatment negatively regulated IAA transport while the Nr mutant showed increased IAA transport in hypocotyls. Ethylene significantly reduces free IAA content in roots, but only subtly changes free IAA content in tomato hypocotyls. These results indicate a negative role of ethylene in lateral root formation and a positive role in adventitious root formation with modulation of auxin transport as a central point of ethylene-auxin crosstalk.

137 Introduction

Development of lateral and adventitious roots are highly plastic processes, which are sensitive to nutrients, moisture, and other environmental parameters, with plant hormones acting as one important signaling mechanism to control these processes (Malamy and

Ryan, 2001; Li et al., 2009). Primary roots form in the embryo and emerge from seeds during germination. As roots mature, quiescent cells within their pericycle layer begin dividing and form lateral root primordia via a precise series of divisions, which are best characterized in Arabidopsis (Malamy and Benfey, 1997). Ultimately, the lateral root elongates and undergoes further reiterative branching. Additionally, when shoot tissues of many plant species contact the soil, they can undergo an intriguing, but poorly characterized process, by which shoot tissues differentiate to form adventitious roots.

Plant propagation relies heavily on the ability of shoot cuttings to effectively generate adventitious roots, yet there is dramatic variation between species in the propensity to form adventitious roots (De Klerk et al., 1999) and little molecular information on this important developmental process.

Auxin positively regulates both lateral and adventitious root formation in most plant species. Elevated endogenous or exogenous concentrations of auxin increase adventitious and lateral root formation (Torrey, 1976; Sitbon et al., 1992; Boerjan et al.,

1995), while reductions in auxin signaling or transport, due to either mutations or inhibitors, reduce both lateral and adventitious root initiation and elongation (Reed et al.,

1998; Casimiro et al., 2001; Laskowski et al., 2008). Auxin and lateral root development have been extensively studied in Arabidopsis (Malamy, 2009), with only a few papers examining the mechanism for auxin’s induction of adventitious root formation in this

138 model species (Ludwig-Muller et al., 2005; Sorin et al., 2005; Sorin et al., 2006; Li et al.,

2009). A limited number of studies have examined root development in tomato (Muday

and Haworth, 1994; Clark et al., 1999; Tyburski and Tretyn, 2004; Ivanchenko et al.,

2006). In tomato, auxin increases lateral (Muday and Haworth, 1994; Muday et al., 1995;

Ivanchenko et al., 2006) and adventitious root growth (Clark et al., 1999; Tyburski and

Tretyn, 2004), while auxin-transport inhibitors reduce formation of both root types

(Muday and Haworth, 1994; Tyburski and Tretyn, 2004). In the auxin-insensitive diageotropic (dgt) mutant, lateral root development is completely inhibited (Muday et al.,

1995; Ivanchenko et al., 2006). Together, these reports suggest that auxin and auxin transport may modulate root development in similar ways in both tomato and Arabidopsis.

Recent studies in Arabidopsis have also identified a role for the gaseous plant

hormone ethylene in lateral root formation, utilizing the diversity of mutants with altered

ethylene signaling or synthesis (Negi et al., 2008, Ivanchenko et al., 2008). The ctr1

mutant, with enhanced ethylene signaling (Kieber et al., 1993; Huang et al., 2003), and

the eto1 mutant, with enhanced ethylene synthesis (Guzman and Ecker, 1990; Kieber et

al., 1993), exhibited significant reductions in lateral root numbers, compared to wild type.

Additionally, treatment with ethylene or the ethylene precursor, 1-aminocyclopropane

carboxylic acid (ACC) reduced lateral root formation (Negi et al., 2008). In contrast the

ethylene insensitive mutants etr1, which has a dominant negative receptor mutation (Hua

et al., 1998; Sakai et al., 1998) and ein2, which has a defect in an ethylene signaling

protein (Kendrick and Chang, 2008), showed enhanced lateral root formation which were

insensitive to ACC treatment (Negi et al., 2008). These ethylene effects are on the earliest

stages of lateral root initiation (Ivanchenko et al., 2008) and alter auxin transport,

139 suggesting that cross talk with auxin is a critical component of the activity of ethylene in lateral root development (Negi et al., 2008).

In tomato, genetic approaches have identified a number of mutants which have defects in ethylene signaling and fruit ripening (Klee, 2004; Barry and Giovannoni, 2007;

Kendrick and Chang, 2008). The Never-ripe (Nr) gene was cloned using a candidate gene approach, as NR exhibits sequence similarity to the Arabidopsis ETR1 gene (Yen et al., 1995; Wilkinson et al., 1995) and is part of the LeETR1-6 gene family (Klee, 2004;

Barry and Giovannoni, 2007; Kendrick and Chang, 2008). Another ethylene signaling mutant with a ripening phenotype is green ripe (gr), a dominant gain-of-function mutant, which exerts its effect by ectopic expression of the GR gene, an ortholog of the

Arabidopsis RTE1 gene (Barry and Giovannoni, 2006; Resnick et al., 2006; Kendrick and

Chang, 2008). Additional tomato fruit ripening mutants include ripening-inhibitor (rin), and non- ripening (nor) (Barry and Giovannoni, 2006). The identity of the NOR gene has not yet been published, but it has been suggested to function upstream of the ethylene signaling pathway (Lincoln and Fischer, 1988; Yokotani et al., 2004). The RIN locus encodes a MADS-Box transcription factor (Vrebalov et al., 2002) that regulates expression of genes including LeACS2, which encodes ACC synthase (Ito et al., 2008), suggesting that the rin mutation alters ethylene synthesis, but may also affect other aspects of ripening. The epi (epinastic) mutant was isolated on the basis of severe leaf epinasty and exhibits an enhanced triple response in the absence of ethylene and has elevated ethylene levels in some tissues (Fujino et al., 1988; Barry et al., 2001).

Although the molecular defect in the epi mutant is not known, it does not share a map position with the tomato CTR1 ortholog (Barry et al., 2001). epi does not demonstrate a

140 global constitutive ethylene response, but shows altered phenotypes in a subset of ethylene responsive tissues (Barry et al., 2001).

The role of ethylene in adventitious root formation has been examined in a variety of plant species, but the results have been contradictory (Robbins et al., 1983;

Geneve and Heuser, 1983). In tomato there have been reports of a positive effect of

ethylene on adventitious root formation (Hitchcock and Zimmerman, 1940; Roy et al.,

1972; Phatak et al., 1981) and negative effects (Coleman et al., 1980). These

contradictory findings may be due to variation in the different tissues, growth conditions,

and methods of quantifying adventitious root formation.

In this study we explored the role of ethylene in lateral and adventitious root

formation in tomato. Few studies have employed a genetic approach to examine the role

of these tomato ethylene signaling mutants in processes beyond fruit ripening and triple

response. Exceptions include evidence that the Green ripe mutant showed reduced

ethylene sensitivity in root elongation (Barry and Giovannoni, 2006), while cuttings of

mature stems of the Nr mutant grown in soil have altered adventitious root formation

(Clark et al., 1999; Kim et al., 2008). The gene expression patterns of tomato ethylene

receptors at distinct developmental stages have been reported (Lashbrook et al., 1998;

Ciardi et al., 2001; Tieman and Klee, 1999), suggesting that ethylene signaling occurs in

a diversity of tissues. We utilized a series of mutants with altered ethylene signaling and

fruit ripening combined with treatments with the ethylene precursor, ACC, to raise

ethylene levels. Lateral root formation is negatively regulated by ethylene, while

adventitious root formation is positively regulated. We also examined the effect of

ethylene on free IAA levels in these plants and examined the effect of ethylene on auxin

141 transport in the primary root and hypocotyl. These results provide insight into the mechanistic basis of ethylene regulated root formation and the cross talk between auxin and ethylene in control of adventitious and lateral root formation. This study broadens the current understanding of the genetic controls of ethylene signaling that regulate root architecture and extends our understanding of this process beyond Arabidopsis into a second agriculturally important species.

142 Results

Ethylene insensitive mutants exhibit enhanced lateral root formation

We examined mutants defective in ethylene signaling and fruit ripening to ask if ethylene modulates root formation in tomato. Root elongation and lateral root formation in the Never ripe mutant (Nr) in two different backgrounds was compared to parental wild-type lines: Pearson (P) and Ailsa Craig (AC). Seedlings were grown along the surface of agar media for 8 days after sowing (Figure IV-1a-c). Both Nr mutants formed more lateral roots than the appropriate wild type with statistically significant 1.4-fold enhanced numbers (P<0.005). We quantified root biomass of seedlings grown in soil for

15 days and Nr showed 2.6-fold enhanced root biomass compared to Pearson (P<0.0005)

(Figure IV-1e-f).

The root phenotype of other fruit ripening mutants; gr, nor, and rin, are also

shown in Figure 1a. All three mutants exhibit a 1.4-fold statistically significant increase

in number of lateral roots (Figure IV-1d; P<0.005). This enhanced root branching of

these mutants is not tied to increases in hypocotyl or leaf growth, as is evident in Figure

1a. The altered lateral root developmental patterns of Nr, gr, rin and nor all suggest that

these gene products function in roots or that they control the long distance transmission

of signals, such as ethylene, to the roots. The known activities of Nr, gr, and rin in

regulating ethylene signaling or synthesis, suggest a negative role of ethylene in lateral

root formation.

Elevated ethylene levels inhibit lateral root formation

143 (a) P Nr (P) AC Nr(AC) VFN8 epi rin gr nor

(b) P Nr (P)AC Nr(AC) VFN8 VFN8

1µM 1µM 1µM 1µM 1µM 0.5 µM (c) (d) 25 30 * 25 * 20 * * * * 20 15 15

10 * 10

5 5 Number of lateral roots Number of lateral roots 0 0 P Nr AC Nr VFN8epi AC Nr nor gr rin (f) (e) 80 70 * 60 50 40 30 20

Root Biomass (mg) 10 Pear so n Nr 0 Pear so n Nr

Figure IV-1: Lateral root formation in tomato is influenced by mutations that alter

ethylene signaling and synthesis.

Roots were grown for 8 days on nutrient agar.

(a) Root phenotypes of seedlings on control or (b) 0.5 or 1µM ACC, as indicated, are

shown.

144 (c) The average number of lateral roots and SE from 15 seedlings is reported.

(d) The average number of emerged lateral roots in each genotype and SE of 15 seedlings

is reported.

(e) Seedlings grown for 15 days in soil are shown. Size bar =1cm

(f) The average and SE of biomass for 10 seedlings are reported.

* Statistically significant differences between genotypes were determined by Student’s t-

test, with P<0.005 as indicated.

145 We examined root formation in the epi (epinastic) mutant, which has enhanced ethylene synthesis and signaling (Fujino et al., 1988) and some ethylene independent phenotypes (Barry et al., 2001), and in wild-type and Nr seedlings treated with ACC, a precursor of ethylene (Figure IV-1a-c). The epi mutant showed a statistically significant two-fold reduction in lateral root formation compared to its wild-type parental line VFN8

(Figure IV-1a,c). ACC treatment of wild-type roots phenocopies the epi mutant, resulting in reduced primary root elongation and reduced number of emerged lateral roots (Figure

IV-1b). This inhibitory effect of ACC on lateral root formation was lost in the Nr mutant, although root elongation is still reduced in Nr at higher doses of ACC (Figure IV-1b).

We quantified the effect of ACC on lateral root numbers in wild type and Nr

(Figure IV-2a). Pearson demonstrated a dose dependent decrease in lateral root formation

with a two-fold reduction in numbers of roots at 10 µM ACC and this effect was lost in

the Nr mutant. At the highest dose of ACC, there is a 2.5-fold difference in lateral roots

between Pearson and Nr. In contrast, Nr was not resistant to the effect of ACC on

primary root elongation (Figure IV-2b). We also examined the effect of ethylene gas on

wild-type and Nr seedlings and found that at doses between 0.5 and 10 µL/L, there was

an inhibition of lateral root formation in Pearson and AC, but no inhibition in Nr (data

not shown).

The Nr mutant in the AC background was slightly sensitive to the effect of ACC

on lateral root formation. At 10 µM ACC only 80% of the untreated number of roots

were formed (21 versus 26 lateral roots, for ACC treated and control roots, respectively;

P<0.0005). This small effect of ACC in Nr in the AC background is consistent with its

description in the literature as Nr exhibiting a weaker phenotype in the AC background

146 (a) (b) 16 18 14 16 12 14 10 12 10 8 8 6 6 4 Pear so n 4 Pear so n 2 Nr Nr

Number of lateral roots lateral of Number 2 Primary root length (cm) length root Primary 0 0 -7.5-∞ -6.5 -5.5 -4.5 -7.5-∞ -6.5 -5.5 -4.5 (c) Log [ACC, M] (d) Log [ACC, M] 18 120 Pr i m o r d i a * Untreated 16 ACC Em er g ed 100 14 To t al # 12 * 80 * 10 # * 60 # 8 6 # 40 4 # # 20 2 % of untreated control untreated of % Number at each stage at Number * 0 0 Pear so n ACC Nr Total Total lateral Average root length root length lateral root (e) (f ) length 9 ** Mature region Pear so n Nr(P) AC Nr(AC) VFN8 epi 8 Elongating region 7 6 5 4

3 * # 2 1 Number of lateral roots lateral of Number 0 Pearson Pearson Nr Nr +ACC +ACC

Figure IV-2: ACC reduces root initiation in Pearson, but not in the Nr mutant.

(a) The effects of ACC on the number of lateral roots were determined, with the average

and SE of 15 seedlings, from 3 separate trials reported.

(b) The effect of a ACC concentrations on the elongation of the primary root was

determined, with the average and SE of 15 seedlings, from 3 separate trials reported.

147 (c) The average number and SE of lateral root primordia, emerged lateral roots, and

combined totals were determined for 6 day old cleared roots one day after transfer to

control media or media containing 1 µM ACC. (n=10 seedlings, from 3 trials) .

(d) Lateral root elongation in Pearson seedlings treated with 1 µM ACC was quantified in

several ways. The length of all lateral and primary root were summed (Total root

length), the length of only lateral roots was summed (total lateral root length), and the

average of the root length is reported for 7 days old roots is presented. The average

and SE of 5 seedlings are presented.

(e) The number of lateral roots that formed on primary root in the mature region

elongating region are shown for seedlings 7 days after transfer to control or ACC

containing media. The average and SE of 10 seedlings, from 3 separate trials are

reported.

(f) The triple response of two Nr alleles and the epi mutant are compared to appropriate

wild-type grown in the dark on control media or media containing ACC for 4 days

after radicle emergence. The seedlings were treated with 0, 1, 5, and 10 µM ACC

from left to right.

* Statistically significant differences relative at each stage of lateral root formation as

indicated in panel c and between untreated and treated Pearson in panel d were

determined by a Student’s t-test, with P<0.005 as indicated.

# Statistically significant differences relative between genotypes in panel d were

determined by a Student’s t-test, with P<0.05 as indicated.

148 (Lanahan et al. 1994). We therefore compared the triple response in the Nr mutant in

both backgrounds to define this difference (Figure IV-2f). At the highest dose Nr

(Pearson) shows no apparent growth inhibition, while Nr (AC) shows partial responses.

Together, these results are consistent with ethylene negatively regulating lateral root

formation in tomato.

Ethylene inhibits lateral root initiation and elongation

We asked whether ethylene exerts its negative role at the stages of lateral root

initiation and/or elongation. Wild-type and Nr roots treated with and without ACC were

cleared to allow visualization and quantification of early stages of root formation (Figure

IV-2c). With ACC treatment there was a significant 1.4-fold reduction in number of initiated and elongated lateral roots (P<0.05). Cleared Nr mutant roots had significantly more primordia and emerged lateral roots than wild type, with 2.6-fold and 1.4-fold increases, respectively. These results indicate that the most profound effects of ACC treatment are at the early stages of lateral root initiation.

To investigate the magnitude of the ethylene effect on lateral root elongation, we calculated the total lateral root length in ACC treated seedling by summing the length of all the lateral roots in each treatment (Figure IV-2d). This parameter has been called a

“tot value” and has been used previously to quantify overall lateral root formation

(Macgregor et al., 2008). The average lengths of lateral roots in ACC treated and control

seedlings are shown in Figure IV-2d. ACC significantly reduced both the number of

lateral roots and the elongation of lateral roots in total and on average for each lateral root.

The effect on lateral roots is more profound than on primary roots.

149 In Arabidopsis, ACC affects lateral root formation in a position specific manner

with decreases in lateral root formation evident only on the primary root formed after

transfer to ACC containing media (Negi et al., 2008; Ivanchenko et al., 2008). We asked

if the ACC effect was also position specific in tomato by examining the effect of ACC on

the mature region (formed before transfer to ACC) and in the elongating region (formed

after transfer to ACC containing media). In Pearson, the number of lateral roots was

significantly reduced in both regions, but with a greater 3-fold reduction in the elongating

region. In Nr, the ACC effect was lost and there were significantly greater number of

lateral roots in the elongating region (Figure IV-2e). These results are consistent with

similar developmental sensitivity to ACC in Arabidopsis and tomato.

Ethylene positively regulates adventitious root formation

Although the negative effect of ACC treatment on lateral root formation in tomato

parallels the effect seen previously in Arabidopsis (Negi et al., 2008; Ivanchenko et al.,

2008), the inhibitory effect of ethylene contrasts with previous reports on adventitious

root formation from hypocotyl tissues in tomato (Clark et al., 1999; Kim et al., 2008),

which was examined in mature plants grown in soil. We therefore asked whether

adventitious roots of tomato showed similar ethylene response to lateral roots examined

in young seedlings grown under similar conditions. After germination, seeds were grown

in low light (5-10 µmol m–2 s–1) for 3 days to elongate the hypocotyl and then transferred

to high light (100 μmol m–2 s–1) for 7 days to observe adventitious root formation (Figure

IV-3a-b). The Nr mutant showed a statistically significant 40% reduction in number of

adventitious roots (P<0.005), consistent with two previous reports that examined older

150 (a) Pearson Pearson +ACC Nr Nr +ACC VFN8 epi

(c) (b) 11 250 Pearson 10 # * Nr 200 9 8 # 150 7 6 * 100 5 * * 4 * 50 3 2 0 1 Number of adventitious roots adventitious of Number Number of adventitious roots, adventitious of Number % of WT Pearson Nr VFN8 epi 0 µM 0.1 µM 1 µM 10 µM ACC Concentration

Figure IV-3: Ethylene enhances adventitious root formation in tomato hypocotyls.

The number of adventitious roots formed 7 days after transfer of seedlings to control

plates or plates with ACC. The average and SE for adventitious roots is shown.

(a) Adventitious root formation in control and 10µM ACC treated Pearson and Nr is

shown. Size bar =1cm

(b) The number of adventitious root was quantified in WT and mutants grown on control

media with n= 8-11, from 2 separate trials for Pearson and Nr and n= 22-25, from 3

separate trials for VFN8 and epi.

(c) The effects of a range of ACC concentrations on the number of adventitious roots

with the average and SE of 19-28 seedlings, from 4 separate trials reported.

* Statistically significant differences between untreated genotypes determined by

Student’s t-test are indicated (P<0.005).

151 # Statistically significant differences within genotype in response to ACC treatment

determined by Student’s t-test are indicated (P< 0.005).

152 tissues grown under very different conditions (Kim et al., 2008; Clark et al., 1999). The

epi mutant showed a statistically significant 1.8-fold increase in adventitious root

formation (P<0.005). Pearson has greater numbers of adventitious roots than Nr at all

ACC doses (Figure IV-3c; P<0.005 at 1 and 10 µM). The ACC treatment of wild type

enhanced the adventitious root formation in a dose dependent manner, with significant

1.4-and 1.8-fold increases at 1 and 10 µM ACC, respectively, while Nr was insensitive to

this effect. This suggests an opposite role for ethylene in regulation of formation of

lateral and adventitious roots.

Ethylene positively regulates auxin transport in tomato roots

We asked whether ethylene might alter root formation through modulation of

auxin transport. Acropetal IAA transport was measured in Pearson and Nr tomato roots in

the presence and absence of ACC (Figure IV-4a). Acropetal transport was quantified by the level of tritiated IAA moving from the site of application at the root shoot junction to

the root tip and is significantly reduced in Nr (P<0.05). In contrast, ACC treatment

resulted in a 2-fold enhancement in number of elongated adventitious roots in Pearson,

but not in Nr. The epi mutant exhibited a 2.5-fold increase in acropetal auxin transport relative to its wild type (Figure IV-4b). ACC treatment also significantly enhanced the acropetal transport of auxin in wild-type seedlings by 2-fold (Figure IV-4a; P<0.005).

Similarly, ACC treatment and the epi mutation significantly increase basipetal auxin transport by 2- and 3.5-fold, respectively (Figure IV-4b-c; P<0.0005). The Nr mutant

showed less basipetal IAA transport than Pearson and the ACC effect was lost in Nr

153 (a) 2.0 Untreated 1.8 * 1µM ACC 1.6 1.4 1.2 1.0 0.8 * 0.6 0.4 0.2 Acropetal IAA transport (fmol) transport IAA Acropetal

0.0 2 (b) Pear so n Nr 450 VFN8 400 epi * 350 300 * 250 200 150 100 50

IAA transport,IAA of% wild type 0 Acropetal (c) Basi p et al 35 Untreated 30 * 1µM ACC 25 20 15 10 * 5

Basipetal IAA transport (fmol) transport IAA Basipetal 0 Pear so n Nr 1

Figure IV-4: In tomato roots acropetal and basipetal IAA transport are positively

regulated by ethylene.

IAA transport was measured 2 days after seedlings were transferred to control media or

media containing 1 µM ACC. The average and SE of 15 seedlings from 3 separate

experiments are reported in all panels.

(a) Acropetal IAA transport is reported.

154 (b) Basipetal IAA transport is reported.

(c) Acropetal and basipetal transport in VFN8 and epi are reported as the percent of wild-

type.

# Statistically significant differences between genotypes was determined by Student’s t-

test is indicated (P<0.05).

* Statistically significant differences between untreated and treated was determined by

Student’s t-test is indicated (P<0.05).

155 (Figure IV-4b). These results indicate that ethylene has a stimulatory effect on both

acropetal and basipetal IAA transport in tomato roots.

Ethylene alters auxin transport in hypocotyls

We also examined the effect of ethylene on auxin transport in tomato hypocotyls.

We applied 10µl agar droplets containing [3H]IAA at the shoot apical end, after removal

of shoot apex. Five hours later, 5mm sections were excised from each hypocotyl at a distance of 2-2.5 cm from the point of application, and the amount of tritiated IAA was

quantified. Nr showed enhanced IAA transport in hypocotyls, with a significant 3-fold increase compared to Pearson (Figure IV-5a; P<0.005). In contrast, auxin transport was

reduced in tomato hypocotyls treated with ACC, while treatment with silver nitrate,

which blocks ethylene signaling, increased auxin transport (Figure IV-5b). This suggests

that ethylene negatively regulates auxin transport in hypocotyls in contrast to root tissues,

where the capacity to transport auxin is increased. Surprisingly, the epi mutant also

showed an increase in hypocotyl IAA transport with a 2.7-fold significant increase in

transport (Figure IV-5b) (P<0.005).

Ethylene alters free IAA content in tomato roots and hypocotyls

We further investigated the effect of ethylene on free auxin content in roots. The

free IAA levels in seedlings on control or 1µM ACC containing media for 48 hrs and root

tissues were quantified (Figure IV-6a-b). Free IAA was extracted and measured using a

gas chromatograph-mass spectrometer operated in the selected ion monitoring mode

13 (GC-SIM-MS) by isotope dilution analysis using [ C6]IAA as the internal standard

156

(a) 8 Co n t r o l # 7 10µM ACC 10µM AgNO3 6 * 5 4 #

( fmole) 3 2 1 Hypocotyl IAA transport (b) 0 Pear so n Nr 350

300 *

250

200

150

100 % of wild of % type 50 Hypocotyl IAA transport, IAA Hypocotyl 0 VFN8 epi

Figure IV-5: Ethylene alters basipetal auxin transport in tomato hypocotyls. The

average ± standard error is reported.

(a) Basipetal IAA transport in Pearson and Never-ripe with and without ACC and

AgNO3 treatment is compared for 8-14 samples from 3 trials.

(b) Basipetal IAA transport in VFN8 and epi are compared in 7-18 samples from 3 trials.

157 * Statistically significant differences between untreated genotypes in panel a and b were

determined by Student’s t-test are indicated (P<0.005).

# Statistically significant differences in Pearson in response to ACC and AgNO3

treatment were determined by Student’s t-test are indicated (P< 0.005).

158 (Barkawi et al., 2008). In Nr, free IAA levels were higher than Pearson and consistent

with these results, ACC treated Pearson roots showed significantly lower concentration

(P<0.05) of free IAA than untreated roots (Figure IV-6 a,b). There is a similar effect of

ACC in all backgrounds (Pearson, AC, and VFN8) with statistically significant 1.5-fold decrease in free IAA, as shown in Figure IV-6a (P<0.05).

To test if ethylene regulates free IAA accumulation in hypocotyls, we measured free IAA levels in Nr and epi, as well as wild type treated with ACC. Low light grown seedlings were transferred to high light conditions for 48 hrs and hypocotyl tissues were harvested and immediately frozen. Free IAA was extracted and quantified using GC-

SIM-MS. Nr showed a slight, but not significant, (20%) reduction in free IAA (Figure

IV-7a). epi also showed a 40% reduction in free IAA levels compared to wild type, but this reduction was also not significant. Additionally, we quantified free IAA levels in wild-type hypocotyls treated with 1 and 10 µM of ACC for 48 hrs (FigureIV-7b).

Surprisingly, no changes in free IAA levels were observed in treated hypocotyls. This may be attributed to a lack of effect of ACC on auxin accumulation. Alternatively, the treatment with ACC might not have been sufficient duration to elicit a response or may have been transient, although similar treatments were found to alter IAA transport. Yet, the global effects of ACC treatment on free IAA in hypocotyls are minimal suggesting that ethylene only subtly changes free IAA, but has a more profound effect on IAA transport.

Nr is insensitive to IAA induced lateral root formation but exhibits reduced response in

adventitious root formation

159 (a) 16 Untreated 14 1µM ACC 12 10 * * 8 * 6 4

Free IAA, (ng/gFW) IAA, Free 2 0 Pearson AC VFN8 (b) 40 35 30 25 20 15 10 Free IAA, (ng/gFW) IAA, Free 5 0 Pear so n Nr

Figure IV-6: In tomato roots free IAA content is reduced two days after 1 µM ACC

treatment.

(a) Free IAA content in three different genotypes quantified after treatment with 1 µM

ACC.

(b) Free IAA content in Pearson and Nr mutant. The average and SE of 3 replicates are

reported.

* Statistically significant differences relative to untreated wild-type were determined by

Student’s t-test are indicated (P<0.05).

160 (a) 9 8 7 6 5 4 3 2 Free IAA, (ng/g FW) IAA, Free 1 0 (b) Pear so n Nr VFN8 epi 10 9 8 7 6 5 4 3

Free IAA, (ng/g FW) IAA, Free 2 1 0 Co n t r o l 1µ M ACC 10µ M ACC

Figure IV-7: Effect of ethylene on free IAA content in tomato hypocotyls are shown.

(a) Free IAA in ethylene mutants Never- ripe and epi are compared to respective wild-

types.

(b) Free IAA in tomato hypocotyls treated with ACC for 48 hours.

(a and b) The average and SE of 3 replicates is reported.

161 We examined the role of auxin during lateral and adventitious root formation and asked whether there is cross-talk between auxin and ethylene signaling pathways.

Pearson and Nr seedlings were grown on control media for one day and then transferred to plates containing control media or media containing IAA and after 7 days lateral root number was quantified. Pearson roots showed significant induction in lateral root formation (P<0.05) with 1.4-fold increase in lateral root number at 10 µM IAA and Nr remained insensitive to this response (Figure IV-8a). These results contrast with

Arabidopsis where ethylene insensitive mutants showed similar induction as wild type in lateral root number when treated with IAA (Negi et al., 2008). These results suggest species specific cross-talk between auxin and ethylene in regulation of lateral root formation.

To examine the IAA effect on adventitious root formation, low light grown

Pearson and Nr seedlings were transferred to control agar or agar containing IAA, and seedlings were placed under high light conditions with a yellow filter to prevent light induced auxin degradation. Adventitious roots formed 7 days later were quantified from

6-21 seedlings (Figure IV-8). IAA enhanced the formation of adventitious roots in

Pearson hypocotyls in a dose dependent manner, with a 1.7-fold induction at 10 µM IAA.

These adventitious roots emerged from the lower half of the hypocotyls as well as at the root shoot junction, similar to the pattern observed with ACC treatment. Nr showed similar induction as Pearson when treated with IAA. This suggests that both ethylene and auxin positively regulates adventitious root formation with auxin sensitivity not requiring ethylene signaling.

162 (a) 160 140 120 100

80 60 40 Pear so n 20 Nr 0

Number of lateral roots of ,% - control-88 -7 -6 -5 (b) log [IAA, M] 12 Pear so n b 10 Nr c 8 c

6 a 4

2

Number of adventitiousroots of Number 0 Control 0.1µM IAA 1µM IAA 10µM IAA

Figure IV-8: Nr has altered responses to auxin in both lateral and adventitious root

formation.

(a) The effects of a range of IAA concentrations on the number of lateral roots were

determined. The average and SE of 15 seedlings were normalized to the untreated

controls for each genotype (with Pearson having 13 and Nr having 16 adventitious

roots).

163 (b) The effects of a range of IAA concentrations on the number of adventitious roots

were determined, with the average and SE of 6-21 seedlings reported here.

Significant differences were determined by Student’s t-test and, a; significant

differences between untreated genotypes, b; with IAA treatment in Pearson and c;

with IAA treatment in Nr are indicated (P<0.05).

164 Discussion

We examined the role of ethylene in modulation of lateral root formation and

adventitious root formation in tomato, utilizing an array of mutants with defects in

ethylene signaling and fruit ripening, including Never ripe (Nr), green ripe (gr), ripening inhibitor (rin) and non ripening (nor), and epinastic (epi). Nr in both Pearson and AC backgrounds formed significantly more lateral roots when grown on agar media, as did gr, rin, and nor. Additionally, quantification of root biomass of 15-day-old soil grown seedlings of both Pearson and Nr showed that Nr has almost 3-fold more root biomass than Pearson. This observation suggests that enhanced root formation in Nr continues beyond the seedling stage and may be amplified when roots are grown in soil, which limits ethylene diffusion more than growth along the surface of unsealed Petri dishes.

Consistent with a negative role of ethylene in lateral root formation, treatment of wild type with the ethylene precursor, ACC, or in the epi mutant, which has been reported to have elevated ethylene levels (Fujino et al., 1988; Barry et al., 2001), reduces the number of initiated and elongated lateral roots, while the Nr mutant was insensitive to the inhibition of lateral root formation by ACC. These experiments confirm the negative role of ethylene during lateral root formation in young tomato seedlings.

In contrast, adventitious root formation exhibited an opposite ethylene dependence. Nr had reduced number of adventitious roots, while ACC treated wild type and the epi mutant had an enhanced number of adventitious roots. Treatment with ACC resulted in expansion of the zone of adventitious root formation, from proliferation only

at the base of the hypocotyl, to a region extending 1-2 cm along the basal part of the

hypocotyl. Examination of adventitious root formation on vegetative stem cuttings of

165 Pearson and Nr found similar differences, with Nr forming reduced numbers compared to

the wild type (Clark et al., 1999). Moreover, Nr has been reported to have reduced

number of adventitious roots in intact plants grown under low phosphorous conditions, as

compared to Pearson (Kim et al., 2008). This positive effect of ethylene on adventitious

roots has also been observed in other species of plants such as in intact plants of Rumex

palustris under conditions of flooding or ethylene application (Visser et al., 1996). These

results suggest a differential role of ethylene in root formation with a negative regulation

during lateral root formation and a positive regulation during adventitious root formation.

Ethylene-auxin cross talk can occur at many different levels including the

modulation of auxin sensitivity, accumulation, and transport. We tested whether ethylene regulates auxin sensitivity during lateral and adventitious root formation in tomato by performing dose response curves with exogenous IAA and quantifying differences in the

Nr mutant. Auxin induced promotion of lateral root formation is lost in Nr. Induction of lateral roots by IAA in wild type was dependent upon developmental stage of treatment, with more induction seen if longer primary roots were present at the time of transfer to media with auxin, and no stimulation in numbers of lateral roots formed when seedlings are transferred to IAA immediately after germination (Muday and Haworth, 1994). In parallel, adventitious roots were induced by auxin treatment in both wild type and Nr, but with Nr never reaching wild-type number of adventitious roots even at 10µM IAA, consistent with a previous report (Clark et al., 1999). Thus, even though auxin may affect lateral and adventitious root formation, the ethylene insensitivity alters IAA response differentially in hypocotyls and roots.

166 Additionally, we tested whether auxin transport is modulated via ethylene.

Previous reports have found that ethylene inhibits polar auxin transport in shoot tissues

(Morgan and Gausman, 1966; Suttle, 1988) and Medicago roots during nodulation

(Prayitno et al., 2006). Basipetal auxin transport was measured in tomato ethylene insensitive mutants in stem tissues under conditions when adventitious root formation occurs. ACC treatment decreased the movement of IAA, consistent with previous reports, while IAA transport was increased in Nr hypocotyls or wild-type hypocotyls treated with silver nitrate, an ethylene signaling antagonist, in comparison to untreated wild type.

Furthermore, Nr mutants were insensitive to both ACC and silver nitrate treatments.

These two findings support a negative role of ethylene in the regulation of hypocotyl auxin transport.

Surprisingly, the epi mutant was found to have increased basipetal hypocotyl IAA transport similar to Nr and opposite to seedlings treated with ACC. As the epi mutation is yet to be cloned, the relationship between this mutation and ethylene signaling remains unclear. Studies that have examined ethylene synthesis have found that hypocotyls of epi had similar level of ethylene as wild type even though the total ethylene content was higher in epi (Fujino et al., 1988). Additionally, epi does not have characteristics of altered ethylene response mutant in all tissues (Barry et al., 2001). Although vegetative growth is altered, fruit ripening and senescence are similar to wild type in epi. Therefore explanation for this contradiction between elevated ethylene and epi phenotype remains unresolved.

In contrast to stem auxin transport, IAA transport was found to be decreased in Nr roots, while ACC treatment and the epi mutation increased root IAA transport. This

167 suggests that ethylene has contrasting roles in roots and hypocotyls with a positive

regulation by ethylene in root, and negative modulation auxin transport in stem tissue.

We initially hypothesized that ACC might reduce root formation by negatively regulating

IAA transport. This positive effect of ACC treatment on root auxin transport contrasted

with this model, but confirms what we found in Arabidopsis (Negi et al. 2008). These

combined results in Arabidopsis and tomato lead us to speculate that perhaps enhanced

long distance polar IAA transport prevents localized accumulation of auxin needed to

drive lateral root formation.

We examined the effect of ACC treatment and mutants on free IAA levels in both

roots and hypocotyls. Several reports have indicated that elevated ethylene levels

enhance the accumulation and synthesis of IAA in Arabidopsis root tips (Stepanova et al.,

2007; Ruzicka et al., 2007; Swarup et al., 2007), so we predicted that free IAA might be

elevated in the ACC treated roots. In contrast to our expectation, significant reductions in

free IAA levels were observed in root tissue in the presence of ACC, while in roots of the

Nr mutant, there were increased levels of free IAA. This suggests that ethylene may

negatively regulate free IAA levels in root tissue, when the whole tissue is examined,

rather than just the tip of Arabidopsis roots (Ruzicka et al., 2007). Additionally, Swarup

et al., (2007) found 3-fold increases in rate of IAA synthesis in intact seedlings treated

with 100µM ACC by specifically measuring the rate of IAA synthesis using D2O feeding

studies. The doses used in that study were 100 fold higher than we used, and at doses that would completely block elongation. Therefore a lack of overall increase we see in free

IAA levels, which is a combination of IAA synthesis, conjugation, and transport in whole root tissues, could be explained by differences in ACC dose, tissue segments, or growth

168 conditions. We find no evidence for global changes in free IAA levels in stem tissue in

Nr or epi, or in wild type treated with ACC. As these experiments were performed with whole hypocotyls, there may be local changes in free IAA level that were not detectable in this assay. Yet, these findings are consistent with more profound effects of ethylene on auxin transport than free auxin levels in hypocotyls.

It is surprising that ACC treatment enhances long distance polar transport within the root, but decreases free IAA levels. If more auxin is being transported from the shoot into the root, then we would predict that there should be higher levels of free IAA. Our transport assays do not directly measure shoot to root movement of IAA, since we apply

IAA below the root shoot junction. To ask if there are differences in IAA transport from the shoot apex into the root, we applied the [3H]IAA at the top of hypocotyls and measured radioactivity along the hypocotyl of wild-type seedlings (data not shown). This assay found that the highest level of IAA was in the region directly above the root shoot junction and that less IAA moved into the root. Therefore, there may be complex regulation of auxin flow as it crosses from the shoot into the root. Additionally, free levels may change as a result of changes in transport, but also synthesis and conjugation, therefore we cannot rule out ACC dependent regulation of free IAA in roots that are transport independent.

An important general question is why it might be advantageous to a plant to enhance adventitious root formation and inhibit lateral root formation with rising ethylene levels? This might be a compensatory mechanism of plants wherein lack of underground root growth is balanced by increases in adventitious roots emerging from the stem of the plants. This has been seen under conditions of submergence in other plant

169 species, where in the development of lateral roots is diminished but at the same time there

is increase in formation of adventitious roots (Visser et al., 1996). Moreover this process

has been shown to be regulated by ethylene through manipulating auxin transport or

synthesis (Visser et al., 1996; Grichko and Glick, 2001).

In conclusion, we find ethylene-auxin cross talk drives root formation in tomato

with tissue specific mechanisms during lateral and adventitious root formation. The

negative effect of ethylene on lateral root formation supports the previously reported

effects on lateral root formation in Arabidopsis. Additionally, we expanded these studies and have looked at the effect of ethylene on adventitious root formation and have found a positive influence of ethylene on adventitious root formation. This ethylene-auxin cross talk includes negative regulation of free auxin accumulation and positive regulation of auxin transport in roots, and negative regulation of auxin transport in shoots. These differences in regulation give a better understanding of complex pathways of ethylene auxin cross talk that regulate lateral and adventitious root development.

170 Methods

Chemicals

Triton X-100 was purchased from Fisher Scientific. Murashige and Skoog (MS)

salts were purchased from Caisson Labs. [5-3H]IAA was purchased from Amersham

(Buckinghamshire, UK; specific activity, 23 Ci mmol–1). All other chemicals were

acquired from Sigma (St. Louis, MO).

Plant material and growth conditions

Nr mutant in Pearson background was provided by Harry Klee (Aloni et al.,

1998), Nr, gr, rin, nor, (all in the AC background) and epi (in the VFN8 background)

mutant seeds were provided by Jim Giovannoni (Barry et al., 2001). All seeds were

sterilized by incubation for 1 min in 95% ethanol, then 30 min in freshly prepared 20%

(v/v) bleach plus 0.01% (v/v) Triton X-100, and then washed with sterile water. The

sterilized seeds were sown on sterilized blue filter papers and after radicle emergence they were transferred to control plates: 0.8% (w/v) Type M agar (A-4800, Sigma), MS nutrients (macro and micro salts: MSP0501, Caisson Labs, Inc.) (Murashige and Skoog,

1962), vitamins (1 µg mL–1 thiamine, 1 µg mL–1 pyridoxine HCl, and 0.5 µg mL–1 nicotinic acid), 0.05% (w/v) MES, with pH adjusted to 5.8. Seedlings were grown under

24 hours of fluorescent lights at 100 μmol m–2 s–1 at 23ºC or as noted. For experiments

with IAA, seedlings were grown under yellow filters to prevent IAA degradation

(Stasinopoulos and Hangarter, 1989). For root biomass quantification seedlings were grown in Metro-Mix 200 for 15 days under constant light at 40-50 µmol m-2 s-1.

Lateral root and adventitious root quantification

171 Seeds were germinated and after radicle emergence, they were transferred to

control agar plates or plated with agar containing the indicated amounts of ACC or IAA.

The emerged lateral roots along the primary root, that were greater than 1 mm long were counted after seven additional days of growth using a dissecting scope.

For quantification of adventitious roots, radicle emerged seedlings were transferred to agar media in Petri dishes, and were placed vertically under 5-10 µmol m-2

s-1. After 3 days of growth they were transferred to 100 µmol m–2 s–1, either on control

agar plates or plates with agar having different concentrations of IAA or ACC. A slab of

approximately 1cm wide control agar was placed across the hypocotyls, to keep the hypocotyls from growing away from the agar media. Adventitious roots emerging from hypocotyl and root shoot junction were counted seven days later.

Detection of lateral root initiation events

Roots from 5 days old seedlings grown on either control media or treatments were

cut and fixed in ethanol:acetic acid (6:1[v/v] overnight. Fixed roots were washed in 100%

ethanol followed by washing in 70% ethanol, These roots were cleared in a mixture of

chloral hydrate:glycerol:water (8:1:2[w/v]) overnight (Al-Hammadi et al., 2003) and

after clearing these roots were observed under dissecting microscope for quantification of

lateral root primordia.

Auxin transport assays

Seeds were germinated and after radicle emergence transferred to control or 1 µM

ACC plates. After 48 hours, a 100 nM [3H]IAA agar cylinder was applied just below the

172 aligned RSJs and the seedlings were incubated in the dark in the inverted position to

prevent [3H]IAA from diffusing along the root, for 18 hours. The apical 5 mm of each root tip was excised and the amount of radioactivity quantified. Individual segments from each plant and position were placed in 2.5 mL scintillation liquid (Scintiverse (TM)

BD cocktail, Fisher chemicals) and radioactivity was measured for 2 min on a Beckman scintillation counter (model LS 6500, Beckman, Fullerton, CA). Measurement of radioactive basipetal auxin transport was performed using the method illustrated by

Lewis and Muday (2009) using same age seedlings as described above treated with 100 nM [3H]IAA agar cylinder applied adjacent to the root tip and the seedlings were incubated in the dark. After 5 hours the apical 2mm of root was excised and discarded and a 5mm segment basal to that was quantified for radioactive IAA.

Quantification of basipetal hypocotyl transport

Seedlings were grown under low light (5-10 µmol m–2 s–1) for 3 days and were

transferred to high light conditions (5-10 µmol m–2 s–1) on control or treatment plates for

48 hrs. The transport was measured by the application of 10mm wide agar droplets with

100 nM [3H]IAA at the shoot apical end after removal of cotyledons. After 5 hrs of

incubation in the dark, 5mm sections at a distance 2.5 cm away from the shoot apical end

was removed and radioactivity was determined using a scintillation counting.

Free IAA Measurements

For root samples, seeds were germinated and after radicle emergence transferred to control or 1 µM ACC plates for 48 hours and roots were excised and frozen in liquid

173 nitrogen. For hypocotyl tissues, samples were grown in low light for 3 days and

transferred to high light conditions onto media with and without 1 or 10 µM ACC for 48

hours and hypocotyls were collected and frozen. For both, 50-80 mg of frozen tissue was

homogenized with a bead beater in 150µl homogenization buffer (35% of 0.2M

13 imidazole, 65% isopropanol, pH 7), containing 4ng of [ C6]IAA as an internal standard.

After 1 hour on ice, samples were subjected to centrifugation at 10,000xg for 8 min. The homogenates were purified over two successive columns using an automated robotic system, methylated, dried, and redissolved in ethyl acetate (Barkawi et al., 2008). The samples were then analyzed using gas chromatograph-mass spectrometer operated in the selected ion monitoring mode (GC-SIM-MS). The free IAA was quantified by isotope

13 dilution analysis using [ C6]IAA as the internal standard (Barkawi et al., 2008).

Acknowledgements

We appreciate the generosity of Harry Klee and Jim Giovonnoni in sharing seeds.

We gratefully acknowledge the Children’s Home of Winston Salem and Pete and Ann

Weigl for providing field space for growth of tomatoes and the assistance of Daniel

Lewis and Kevin Cooper in maintaining this field site. This work was supported by the

USDA National Research Initiative Competitive Grants Program (grant 2006-03406 to

GKM and grant 2004-02816 to JDM) and NSF grant MCB-0725149 to JDC, and the

Gordon and Margaret Bailey Endowment for Environmental Horticulture to JDC.

174 Literature cited

Al-Hammadi, A.S., Sreelakshmi, Y., Negi, S., Siddiqi, I. and Sharma, R. (2003) The

polycotyledon mutant of tomato shows enhanced polar auxin transport. Plant

Physiol, 133, 113-125.

Barkawi, L.S., Tam, Y.Y., Tillman, J.A., Pederson, B., Calio, J., Al-Amier, H.,

Emerick, M., Normanly, J. and Cohen, J.D. (2008) A high-throughput method

for the quantitative analysis of indole-3-acetic acid and other auxins from plant

tissue. Anal Biochem, 372, 177-188.

Barry, C.S., Fox, E.A., Yen, H., Lee, S., Ying, T., Grierson, D. and Giovannoni, J.J.

(2001) Analysis of the ethylene response in the epinastic mutant of tomato. Plant

Physiol, 127, 58-66.

Barry, C.S. and Giovannoni, J.J. (2006) Ripening in the tomato Green-ripe mutant is

inhibited by ectopic expression of a protein that disrupts ethylene signaling. Proc

Natl Acad Sci U S A, 103, 7923-7928.

Barry, C.S. and Giovannoni, J.J. (2007) Ethylene and fruit ripening. Journal of Plant

Growth Regulation, 26, 143-159.

Boerjan, W., Cervera, M.-T., Delarue, M., Beeckman, T., Dewitte, W., Bellini, C.,

Caboche, M., van Onckelen, H., Van Montagu, M. and Inze, D. (1995)

Superroot, a recessive mutation in Arabidopsis, confers auxin overproduction.

Plant Cell, 7, 1405-1419.

Casimiro, I., Marchant, A., Bhalerao, R.P., Beeckman, T., Dhooge, S., Swarup, R.,

Graham, N., Inzé, D., Sandberg, G., Casero, P.J. and Bennett, M. (2001)

175 Auxin transport promotes Arabidopsis lateral root initiation. Plant Cell, 13, 843-

852.

Ciardi, J.A., Tieman, D.M., Jones, J.B. and Klee, H.J. (2001) Reduced expression of

the tomato ethylene receptor gene LeETR4 enhances the hypersensitive response

to Xanthomonas campestris pv. vesicatoria. Molecular Plant-Microbe

Interactions, 14, 487-495.

Clark, D.G., Gubrium, E.K., Barrett, J.E., Nell, T.A. and Klee, H.J. (1999) Root

formation in ethylene-insensitive plants. Plant Physiol, 121, 53-60.

Coleman, W., Huxter, T., Reid, D. and Thrope, T. (1980) Ethylene as an endogenous

inhibitor of root regeneration in tomato leaf disc cultures in vitro. Physiol Plant,

48, 519-525.

De Klerk, G.-J., Van Der Krieken, W. and De Jong, J. (1999) The formation of

adventitious roots: New concepts, new possibilities. In Vitro Cell Dev Biol-Plants,

35, 189-199.

Fujino, D.W., Burger, D.W., Yang, S.F. and Bradford, K.J. (1988) Characterization

of an Ethylene Overproducing Mutant of Tomato (Lycopersicon esculentum Mill.

Cultivar VFN8). Plant Physiol, 88, 774-779.

Geneve, R. and Heuser, C. (1983) The relationship between ethephon and auxin on

adventitious root intiation in cuttings of Vigna radiata (L.) R. Wilcz. J Am Soc

Hortic Sci, 108, 330-333.

Grichko, V. and Glick, B. (2001) Ethylene and flooding stress in plants. Plant Physiol

Biochem, 39, 1-9.

176 Guzman, P. and Ecker, J.R. (1990) Exploiting the Triple Response of Arabidopsis to

Identify Ethylene-Related Mutants. Plant Cell, 2, 513-523.

Hitchcock, A. and Zimmerman, P. (1940) Effects obtained with mixtures of root-

inducing and other substances. Contrib Boyce Thompson Inst, 11, 155-159.

Hua, J., Sakai, H., Nourizadeh, S., Chen, Q.G., Bleecker, A.B., Ecker, J.R. and

Meyerowitz, E.M. (1998) EIN4 and ERS2 are members of the putative ethylene

receptor gene family in Arabidopsis. Plant Cell, 10, 1321-1332.

Huang, Y., Li, H., Hutchison, C.E., Laskey, J. and Kieber, J.J. (2003) Biochemical

and functional analysis of CTR1, a protein kinase that negatively regulates

ethylene signaling in Arabidopsis. Plant J, 33, 221-233.

Ito, Y., Kitagawa, M., Ihashi, N., Yabe, K., Kimbara, J., Yasuda, J., Ito, H.,

Inakuma, T., Hiroi, S. and Kasumi, T. (2008) DNA-binding specificity,

transcriptional activation potential, and the rin mutation effect for the tomato

fruit-ripening regulator RIN. Plant J, 55, 212-223.

Ivanchenko, M.G., Coffeen, W.C., Lomax, T.L. and Dubrovsky, J.G. (2006)

Mutations in the Diageotropica (dgt) gene uncouple patterned cell division during

lateral root initiation from proliferative cell division in the pericycle. Plant J, 46,

436-447.

Ivanchenko, M.G., Muday, G.K. and Dubrovsky, J.G. (2008) Ethylene-auxin

interactions regulate lateral root initiation and emergence in Arabidopsis thaliana.

Plant J.

Kendrick, M.D. and Chang, C. (2008) Ethylene signaling: new levels of complexity

and regulation. Curr Opin Plant Biol, 11, 479-485.

177 Kieber, J.J., Rothenberg, M., Roman, G., Feldmann, K.A. and Ecker, J.R. (1993)

CTR1, a negative regulator of the ethylene response pathway in Arabidopsis,

encodes a member of the Raf family of protein kinases. Cell, 72, 427-441.

Kim, H.J., Lynch, J.P. and Brown, K.M. (2008) Ethylene insensitivity impedes a

subset of responses to phosphorus deficiency in tomato and petunia. Plant Cell

Environ, 31, 1744-1755.

Klee, H.J. (2004) Ethylene signal transduction. Moving beyond Arabidopsis. Plant

Physiol, 135, 660-667.

Lashbrook, C.C., Tieman, D.M. and Klee, H.J. (1998) Differential regulation of the

tomato ETR gene family throughout plant development. Plant J, 15, 243-252.

Laskowski, M., Grieneisen, V.A., Hofhuis, H., Hove, C.A., Hogeweg, P., Maree, A.F.

and Scheres, B. (2008) Root system architecture from coupling cell shape to

auxin transport. PLoS Biol, 6, e307.

Li, S.W., Xue, L.G., Xu, S.J., Feng, H.Y. and An, L.Z. (2009) Mediators, Genes and

Signaling in Adventitious Rooting. Botanical Review, 75, 230-247.

Lincoln, J.E. and Fischer, R.L. (1988) Regulation of Gene Expression by Ethylene in

Wild-Type and rin Tomato (Lycopersicon esculentum) Fruit. Plant Physiol, 88,

370-374.

Ludwig-Muller, J., Vertocnik, A. and Town, C.D. (2005) Analysis of indole-3-butyric

acid-induced adventitious root formation on Arabidopsis stem segments. J Exp

Bot, 56, 2095-2105.

Lynch, J. (1995) Root Architecture and Plant Productivity. Plant Physiol, 109, 7-13.

178 Macgregor, D.R., Deak, K.I., Ingram, P.A. and Malamy, J.E. (2008) Root system

architecture in Arabidopsis grown in culture is regulated by sucrose uptake in the

aerial tissues. Plant Cell, 20, 2643-2660.

Malamy, J. and Benfey, P. (1997) Organization and cell differentiation in lateral roots

of Arabidopsis thaliana. Development, 124, 33-44.

Malamy, J. (2009) Lateral Root Development. Root Development. Beeckman, T.,

Oxford, UK: Blackwell Publishing Limited, In press.

Malamy, J.E. and Ryan, K.S. (2001) Environmental regulation of lateral root initiation

in Arabidopsis. Plant Physiol, 127, 899-909.

Morgan, P. and Gausman, H. (1966) Effects of ethylene on auxin transport. Plant

Physiol, 41, 45-52.

Muday, G.K. and Haworth, P. (1994) Tomato root growth, gravitropism, and lateral

development: correlation with auxin transport. Plant Physiol Biochem, 32, 193-

203.

Muday, G.K., Lomax, T.L. and Rayle, D.L. (1995) Characterization of the growth and

auxin physiology of roots of the tomato mutant, diageotropica. Planta, 195, 548-

553.

Murashige, T. and Skoog, F. (1962) A revised medium for rapid growth and bioassays

with tobacco tissue cultures. Physiologia Plantarum, 15, 473-479.

Negi, S., Ivanchenko, M.G. and Muday, G.K. (2008) Ethylene regulates lateral root

formation and auxin transport in Arabidopsis thaliana. Plant J, 55, 175-187.

Phatak, S., Jaworski, C. and Liptay, A. (1981) Flowering and adventitious root growth

of tomato cultivars as influenced by ethephon. HortScience, 16, 181-182.

179 Prayitno, J., Rolfe, B.G. and Mathesius, U. (2006) The Ethylene-insensitive sickle

mutant of Medicago truncatula shows altered auxin transport regulation during

nodulation. Plant Physiol, 142, 168-180.

Reed, R.C., Brady, S.R. and Muday, G.K. (1998) Inhibition of auxin movement from

the shoot into the root inhibits lateral root development in arabidopsis. Plant

Physiol, 118, 1369-1378.

Resnick, J.S., Wen, C.K., Shockey, J.A. and Chang, C. (2006) REVERSION-TO-

ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor

function in Arabidopsis. Proc Natl Acad Sci U S A, 103, 7917-7922.

Robbins, J., Kays, S. and Dirr, M. (1983) Enhanced rooting of wounded mung bean

cuttings by wounding and ethephon. J Am Soc Hortic Sci, 108, 325-329.

Roy, B., Basu, R. and Bose, T. (1972) Interaction of auxins with growth-retarding, -

inhibiting and ethylene-producing chemicals in rooting of cuttings. Plant Cell

Physiol, 13, 1123-1127.

Ruzicka, K., Ljung, K., Vanneste, S., Podhorska, R., Beeckman, T., Friml, J. and

Benkova, E. (2007) Ethylene regulates root growth through effects on auxin

biosynthesis and transport-dependent auxin distribution. Plant Cell, 19, 2197-

2212.

Sakai, H., Hua, J., Chen, Q.G., Chang, C., Medrano, L.J., Bleecker, A.B. and

Meyerowitz, E.M. (1998) ETR2 is an ETR1-like gene involved in ethylene

signaling in Arabidopsis. Proc Natl Acad Sci U S A, 95, 5812-5817.

Sitbon, F., Hennion, S., Sundberg, B., Little, C.H.A., Olsson, O. and Sandberg, G.

(1992) Transgenic tobacco plants coexpressing the tumefaciens

180 iaaM and iaaH genes display altered growth and indoleacetic acid metabolism.

Plant Physiol., 99, 1062-1069.

Sorin, C., Bussell, J.D., Camus, I., Ljung, K., Kowalczyk, M., Geiss, G., McKhann,

H., Garcion, C., Vaucheret, H., Sandberg, G. and Bellini, C. (2005) Auxin and

light control of adventitious rooting in Arabidopsis require ARGONAUTE1.

Plant Cell, 17, 1343-1359.

Sorin, C., Negroni, L., Balliau, T., Corti, H., Jacquemot, M.P., Davanture, M.,

Sandberg, G., Zivy, M. and Bellini, C. (2006) Proteomic analysis of different

mutant genotypes of Arabidopsis led to the identification of 11 proteins

correlating with adventitious root development. Plant Physiol, 140, 349-364.

Stasinopoulos, T.C. and Hangarter, R.P. (1989) Preventing photochemistry in culture

media by long-pass light filters alters growth of cultured tissues. Plant Physiol, 93,

1365-1369.

Stepanova, A.N., Yun, J., Likhacheva, A.V. and Alonso, J.M. (2007) Multilevel

interactions between ethylene and auxin in Arabidopsis roots. Plant Cell, 19,

2169-2185.

Suttle, J.C. (1988) Effect of ethylene treatment on polar IAA transport, net IAA uptake

and specific binding of N-1-naphthylphthalamic acid in tissues and microsomes

isolated from etiolated pea epicotyls. Plant Physiol., 88, 795-799.

Swarup, R., Perry, P., Hagenbeek, D., Van Der Straeten, D., Beemster, G.T.,

Sandberg, G., Bhalerao, R., Ljung, K. and Bennett, M.J. (2007) Ethylene

upregulates auxin biosynthesis in Arabidopsis seedlings to enhance inhibition of

root cell elongation. Plant Cell, 19, 2186-2196.

181 Tieman, D.M. and Klee, H.J. (1999) Differential expression of two novel members of

the tomato ethylene-receptor family. Plant Physiology, 120, 165-172.

Torrey, J.G. (1976) Root hormones and plant growth. Ann Rev Plant Physiol, 27, 435-

459.

Tyburski, J. and Tretyn, A. (2004) The role of light and polar auxin transport in root

regenration from hypocotyls of tomato seedling cuttings. Plant Growth Reg, 42,

39-48.

Visser, E., Cohen, J.D., Barendse, G., Blom, C. and Voesenek, L. (1996) An Ethylene-

Mediated Increase in Sensitivity to Auxin Induces Adventitious Root Formation

in Flooded Rumex palustris Sm. Plant Physiol, 112, 1687-1692.

Vrebalov, J., Ruezinsky, D., Padmanabhan, V., White, R., Medrano, D., Drake, R.,

Schuch, W. and Giovannoni, J. (2002) A MADS-box gene necessary for fruit

ripening at the tomato ripening-inhibitor (Rin) locus. Science, 296, 343-346.

Wilkinson, J.Q., Lanahan, M.B., Yen, H.C., Giovannoni, J.J. and Klee, H.J. (1995)

An ethylene-inducible component of signal transduction encoded by Never- ripe

Science, 270, 1807-1809.

Yen, H.C., Lee, S., Tanksley, S.D., Lanahan, M.B., Klee, H.J. and Giovannoni, J.J.

(1995) The tomato Never-ripe locus regulates ethylene-inducible gene expression

and is linked to a homolog of the Arabidopsis ETR1 gene. Plant Physiol, 107,

1343-1353.

Yokotani, N., Tamura, S., Nakano, R., Inaba, A., McGlasson, W.B. and Kubo, Y.

(2004) Comparison of ethylene- and wound-induced responses in fruit of wild-type, rin and nor tomatoes. Postharvest Biology and Technology, 32, 247-252.

182 CHAPTER V

CONCLUSION

This research explored the mechanisms by which auxin and ethylene regulate

development of roots from the stem of plants, a process called adventitious root

formation. We have used Arabidopsis and its widely available mutants and transgenic

lines, as well as the agriculturally important species of tomato, with its more limited genetics resources, to dissect the hormonal controls of development of adventitious roots,

as well as understand the species specific effect of hormones. These results have

uncovered a critical function for auxin and ethylene physiology in modulating the

development of adventitious roots.

Though adventitious roots serve numerous functions in plants, the ability to form

adventitious roots is species specific. We find that tomato forms many adventitious roots,

while Arabidopsis forms almost no adventitious roots, unless the base of hypocotyls and

roots has been excised. Root excision enhanced the formation of adventitious roots by

approximately 10-fold in Arabidopsis, while only a 2-3 fold increase with a similar treatment was seen in tomato. This difference of the rooting between these plants makes physiological sense in the context of the architecture of the shoot of these plants. Tomato

grows as a bushy vine, while Arabidopsis grows as a rosette. Tomato, if grown upright

can reach up to 5-6 meters, while Arabidopsis forms small stems, with inflorescences

reaching approximately 15-20 cm. Tomato, having a larger shoot structure, which grows

along the soil surface, possibly benefits from adventitious roots that increase the surface

area for nutrient and moisture uptake. Therefore an apparent selective advantage of

adventitious root formation is evident in tomato.

183 This thesis also examines the mechanism by which excision of stems can enhance

adventitious root formation and the role of auxin in this process. Stem cuttings, with or

without auxin treatments, have been used to propagate commercially important species

(reviewed in De-Klerk et al., 1999). Though this practice has been used for many years,

the mechanism by which cutting of stems induce adventitious roots is unknown. We

utilized Arabidopsis hypocotyls from which roots were excised. We have demonstrated a

positive role for shoot apex derived auxin and exogenously applied auxin in stimulation

of adventitious roots. Additionally, excision enhanced auxin transport from the shoots

leads to localized auxin accumulation above the site of excision. This change in auxin

accumulation was found to precede the development of adventitious roots. The change in

auxin accumulation was limited to 1-2 mm above the site of excision, coinciding with

positions of adventitious root formation. There was no change in overall free IAA levels

through out the hypocotyl as a result of excision. The lack of change is overall auxin

accumulation is consistent with previous studies looking for changes in free IAA levels

during the development of adventitious roots under different conditions. In apple stem cuttings and flooded Rumex palustris no significant changes in free IAA levels were

found (reviewed in De-Klerk et al., 1999; Visser et al., 1996). These results are consistent with changes in auxin distribution, rather than synthesis, leading to formation of

adventitious roots after excision, and suggest a role for auxin transport in this process.

Alterations in expression, activity and or localization of auxin transport proteins

are important in mediating changes driving physiological processes. We find that

excision enhanced auxin transport is mediated by auxin transport proteins ABCB19 and

PIN1, as defects in these proteins result in reduced adventitious root formation.

184 Additionally, we find increases in transcript levels of PIN1 with excision. In contrast,

changes in ABCB19-GFP protein accumulation were found without changes in transcript

levels. This change in protein accumulation may be due to dephosphorylation as

treatments with the phosphatase inhibitor, canthardin, causing reduction in accumulation

of ABCB19, and auxin transport in hypocotyls. Interestingly, canthardin treatments

changed the location of emergence of adventitious roots and associated auxin accumulation, without altering the number of roots formed. These results suggest that changes in transcription, as well as protein modifications, are involved in mediating auxin

transport that drives the formation of adventitious roots.

Our result that PIN1 mediated auxin transport is required for adventitious root

formation is consistent with OsRNAi lines of PIN1 in rice having reduced formation of

adventitious roots (Xu et al., 2005). Additionally, defects in a guanine nucleotide

exchange factor for ADP-ribosylation factor; GNOM, a known regulator of localization

of auxin transport protein in Arabidopsis, resulted in reduced formation of adventitious

roots as well as altered expression of PIN proteins in rice (Liu et al., 2009). Furthermore,

consistent with our observation that protein phosphorylation is involved in modulating

adventitious root formation, over expressing lines of PID (a serine theronine protein

kinase) was found to have delayed formation of adventitious roots in rice (Morita and

Kyozuka, 2007). This confirms that changes in auxin physiology involve modulation of

transcription as well as post-transcriptional changes during adventitious root formation.

Moreover the mediators of auxin transport required for adventitious root formation seems

to be conserved between at least some of the species.

185 Ethylene is involved in the regulation of lateral root formation in tomato and

Arabidopsis (Negi et al., 2008; Negi et al., 2010). Therefore, we asked if ethylene may modulate adventitious root formation. Treatments with the ethylene precursor ACC caused reduction of formation of adventitious roots in Arabidopsis. Mutants that are insensitive to ethylene have enhanced adventitious root formation, while ethylene overproducing and constitutive mutants have reduced formation of adventitious roots.

These results indicate that ethylene negatively regulates adventitious roots in Arabidopsis.

In contrast, in tomato both treatment with ACC and examination of mutants with altered ethylene signaling and synthesis yielded an opposite conclusion. In wild type treated with ACC, and in mutants with enhanced ethylene synthesis, tomato hypocotyls formed enhanced number of adventitious roots, while ethylene insensitive mutants had fewer adventitious roots than control wild type. Additionally, ACC treatment resulted in the expansion of localization of formation of adventitious roots. The positive effect of ethylene in our experiments is supported by previous experiments looking at the effect of ethylene in tomato (Clark et al., 1999; Roy et al., 1972; Kim et al., 2008). These results suggest that, opposite to the effect on Arabidopsis, ethylene positively regulates adventitious root formation in tomato. Moreover, ethylene negatively regulates lateral root formation in tomato. The positive effect of ethylene on adventitious root formation seen in tomato might be a compensatory mechanism seen similar to that is reported for plants growing under flooded conditions (Visser et al., 1996). Under flooded conditions, the functioning of primary root and lateral root system is impaired by limited oxygen exchange. Stimulation of growth of adventitious roots that are above the point of flooding under such conditions would then help plants adapt to such situations. Thus, different

186 from auxin, which has a positive effect on adventitious roots in both species, the effect of

ethylene seems specific to the species and to the type of root development.

Ethylene-auxin cross talk has been shown to modulate other root processes such

as elongation, lateral root formation, and gravity response (Ruzicka et al., 2007; Negi et al., 2008; Buer et al., 2006). Earlier studies have looked at this phenomenon during adventitious root formation in several species of plants (Riov and Yang, 1989; Visser et al., 1996; Clark et al., 1999), but there has been no study that utilized the genetic tools to understand hormonal interaction modulating adventitious root formation. We examined the role of ethylene in altering auxin transport and or synthesis in Arabidopsis and tomato using mutants defective in ethylene signaling and synthesis, and find that ethylene negatively regulates auxin transport without having an effect on overall free IAA levels in both these species. The negative effect of ethylene on auxin transport in Arabidopsis was in part due to its negative effect on ABCB19 accumulation. The relationship between ethylene regulated changes in auxin transport and the adventitious root pattern is also dissimilar between these species. Decreased auxin transport after ACC treatment correlates with enhanced adventitious root formation in tomato, while ethylene induced decrease in auxin transport in Arabidopsis is correlated with decrease in adventitious root formation. The reason for this contrasting effect of ethylene on auxin transport and adventitious root formation in two species is mysterious. Additionally, in Arabidopsis, ethylene insensitive mutants exhibited enhanced local auxin accumulation, consistent with its phenotype of increased adventitious root formation. This suggests that ethylene negatively regulates auxin transport and local auxin accumulation in Arabidopsis.

187 Conditions of stress such as wounding induces accumulation of secondary

metabolites called flavonoids (reviewed in Winkel-Shirley, 2002). Flavonoids have been

shown to inhibit auxin transport in roots (reviwed in Winkel-Shirley, 2002; Buer and

Muday, 2004; Peer et al., 2004). We find that excision enhances flavonoid accumulation

regionally near the point of excision in Arabidopsis. This localized accumulation of flavonoids may be important for blocking auxin out of hypocotyls, in turn resulting in accumulation of auxin 1-2mm above the site of excision. Consistent with this hypothesis, we find that the absence of flavonoids in tt4-2 mutants cause them to be less sensitive to excision induced enhancement of adventitious root formation and auxin transport. This change in flavonoid accumulation is at least partly due to changes in transcript accumulation of enzyme involved in the flavonoid biosynthetic pathway, as determined by qRT-PCR. Additionally, the eto1-1 mutant, which has increased ethylene synthesis, was found to have enhanced accumulation of transcripts of the flavonoid biosynthetic enzyme, suggesting that ethylene increases flavonoid accumulation. Thus, our results suggest that flavonoids can regulate auxin transport and possibly auxin accumulation,

driving the formation of adventitious roots.

Few studies have looked at the importance of wound released compounds in

development of adventitious root formation. In apple stem cuttings, application of

wounding related compounds along with suboptimal IBA application, although not by

itself, was able to induce adventitious root formation (reviewed in De-Klerk et al., 1999).

No change is auxin accumulation was found in stem with treatment of wounding related

compounds (reviewed in De-Klerk et al., 1999). Conversely, in hypocotyls of Impatiens

balsamina, anthocyanin content and distribution was found to be under the regulation of

188 auxin, with enhanced anthocyanins increasing the formation of adventitious roots (Arnold and Albert, 1964). But in the internode segments of sorghum, no correlation was found between accumulation of anthocyanins and initiation of adventitious roots (Stafford,

1968). These reports indicate that there might be a complex relation between wound- induced compounds, including flavonoids, and their regulation of adventitious root

formation in different species.

Based on the results from these experiments, I propose a model to integrate the

events that are important for excision enhanced adventitious root formation in

Arabidopsis, as shown in Figure V-1 and V-II. Excision induces flavonoid accumulation

as soon as 4 hrs, followed by increased accumulation of auxin transport protein at 6hrs after excision. This causes an increase in auxin transport. This movement of auxin is

blocked 1-2 mm above the site of excision, possibly caused by flavonoid accumulation,

resulting in local auxin accumulation at 9 hrs. This leads to cell division and

differentiation for the development of adventitious root formation, starting at 18 hrs after

excision. Emerged adventitious root can be seen 72 hrs after excision. Additionally, treatment with ethylene causes reduction in auxin transport through increasing flavonoid

accumulation, decreasing the accumulation of ABCB19, resulting in reduced auxin

accumulation at the site of excision, and leading to reduced adventitious root formation.

Together these results have helped in unraveling the mechanism by which ethylene and

auxin regulate the process of adventitious root formation.

The next step in this project would be to further investigate whether flavonoids

directly interact with ABCB19 in regulating auxin transport and accumulation, and

identifying the target of canthardin. In addition, exploring the role of ABCB19 in

189 0 hrs Root excision

4hrs ↑flavonoid accumulation 6hrs ↑expression and accumulation of auxin transport proteins 9hrs ↑Local auxin induced gene expression 18 hrs Primordia formation

72 hrs Emerged adventitious roots

Increased movement of auxin Local flavonoid accumulation Accumulation of auxin Adventitious root primordium

Emerged adventitious root

190 Figure V-1: Model for excision induced adventitious root formation.

In Arabidopsis, excision induces flavonoids accumulation blocks auxin movement causing auxin accumulation above the site of excision which leads to development of adventitious roots.

191

192 Figure V-1I: Cell model for excision induced adventitious root formation.

Excision enhances transport of auxin through increased transcription of PIN1 and increased accumulation of ABCB19. This movement is blocked by flavonoid accumulation causing enhanced auxin accumulation above the site of excision which leads to development of adventitious roots. ACC treatment reduces auxin transport into the cells, through decreasing ABCB19 accumulation and enhancing flavonoid accumulation, which results in reduced auxin accumulation. This results in decreased adventitious root formation.

193 adventitious root formation in tomato would provide insight into the role of these auxin transport proteins in adventitious root formation across species. Thus, the experiments detailed in this thesis provide a framework for understanding adventitious root formation.

194 Literature cited

Arnold AW, Albert SI (1964) Chemical facotrs affecting anthocyanin formation and

morphogenesis in culutured hypocotyl segments of Impateins balsamina. Plant

Physiol 39: 307-312

Buer CS, Muday GK (2004) The transparent testa4 mutation prevents flavonoid

synthesis and alters auxin transport and the response of Arabidopsis roots to

gravity and light. Plant Cell 16: 1191-1205

Buer CS, Sukumar P, Muday GK (2006) Ethylene modulates flavonoid accumulation

and gravitropic responses in roots of Arabidopsis. Plant Physiology 140: 1384-

1396

Clark DG, Gubrium EK, Barrett JE, Nell TA, Klee HJ (1999) Root formation in

ethylene-insensitive plants. Plant Physiol 121: 53-60

De-Klerk G, Krieken W, DeJong J (1999) The formation of adventitious roots: New

concepts, new possibilities. In Vitro Cell Dev Biol-Plant 35: 189-199

Kim HJ, Lynch JP, Brown KM (2008) Ethylene insensitivity impedes a subset of

responses to phosphorus deficiency in tomato and petunia. Plant Cell Environ 31:

1744-1755

Liu SP, Wang JR, Wang L, Wang XF, Xue YH, Wu P, Shou HX (2009) Adventitious

root formation in rice requires OsGNOM1 and is mediated by the OsPINs family.

Cell Research 19: 1110-1119

Morita Y, Kyozuka J (2007) Characterization of OsPID, the rice ortholog of PINOID,

and its possible involvement in the control of polar auxin transport. Plant and Cell

Physiology 48: 540-549

195 Negi S, Ivanchenko MG, Muday GK (2008) Ethylene regulates lateral root formation

and auxin transport in Arabidopsis thaliana. Plant J 55: 175-187

Negi S, Sukumar P, Liu X, Cohen JD, Muday GK (2010) Genetic dissection of the

role of ethylene in regulating auxin-dependent lateral and adventitious root

formation in tomato. Plant J 61: 3-15

Peer WA, Bandyopadhyay A, Blakeslee JJ, Makam SI, Chen RJ, Masson PH,

Murphy AS (2004) Variation in expression and protein localization of the PIN

family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin

transport in Arabidopsis thaliana. Plant Cell 16: 1898-1911

Riov J, Yang S (1989) Ethylene and Auxin-ethylene interaction in adventiitous root

formation in Mung bean (Vigna radiata) cuttings. Journal of Plant Growth

Regulation 8: 131-141

Roy B, Basu R, Bose T (1972) Interaction of auxins with growth-retarding, -inhibiting

and ethylene-producing chemicals in rooting of cuttings. Plant Cell Physiol 13:

1123-1127

Ruzicka K, Ljung K, Vanneste S, Podhorska R, Beeckman T, Friml J, Benkova E

(2007) Ethylene regulates root growth through effects on auxin biosynthesis and

transport-dependent auxin distribution. Plant Cell 19: 2197-2212

Stafford HA (1968) Relationships between the development of adventitious roots and

the biosynthesis of anthocyanins in first internodes of sorghum. Plant Physiol 43:

318-326

196 Visser E, Cohen JD, Barendse G, Blom C, Voesenek L (1996) An Ethylene-Mediated

Increase in Sensitivity to Auxin Induces Adventitious Root Formation in Flooded

Rumex palustris Sm. Plant Physiol 112: 1687-1692

Winkel-Shirley B (2002) Biosynthesis of flavonoids and effects of stress. Current

Opinion in Plant Biology 5: 218-223

Xu M, Zhu L, Shou HX, Wu P (2005) A PIN1 family gene, OsPIN1, involved in auxin-

dependent adventitious root emergence and tillering in rice. Plant and Cell

Physiology 46: 1674-1681

197 APPENDIX

ADVENTITIOUS ROOTS AS A MODEL TO STUDY AUXIN CANALIZATION

Introduction

The plant hormone, auxin is thought to have a feedback regulation on localization of efflux carriers (Paciorek et al., 2005). Relocalization of PIN1 proteins have been observed during floral primordia development in shoots, which is attributed to local changes in auxin concentration during primordia development. Additionally, auxin can prevent internalization of efflux carriers and thus promote its own transport (Paciorek et al., 2005). This suggests that there is an intricate connection between auxin transport and efflux carrier localization to coordinate plant development and morphogenesis. The idea that auxin can regulate its own transport is the central feature of the canalization hypothesis proposed by Sachs (Sachs, 1981). This hypothesis suggests that auxin can direct its own transport through a feedback effect, strengthening its polar movement.

Events leading to vascular development in cotyledons, leaves, and stems have been proposed to be auxin driven based on this hypothesis (Sachs, 1986). This feedback by auxin to regulate its own transport may occur at many levels including signaling, synthesis, or localization of efflux carriers. The positive regulation of auxin on its own transport through canalization has been proposed by Sauer et al during changes in auxin accumulation induced by IAA treatments or during wounding and lateral root formation

(Sauer et al., 2007). They found changes in localization of PIN1 and PIN2 during these processes, regulation of which was dependent on AUX/IAA and ARF signaling (Sauer et al., 2007). In addition, two other experiments looked at auxin movements in stem cuttings of Tomato and Tagetes and found contradictory physiological evidence on auxin induced

198 polar movement (Sheldrake, 1974,Went, 1941). Using Arabidopsis to study the movement of auxin, provides an advantage as the wide array of mutants and transgenic lines could be used to dissect the molecular mechanism of this process.

The goal of these experiments is to test whether the polarity of auxin transport can be reversed by altering local auxin concentrations consistent with the canalization hypothesis. These experiments utilize Arabidopsis hypocotyls and formation of adventitious roots as a model system. Arabidopsis seedlings, when grown under low light condition, form elongated hypocotyls, which can be induced to form adventitious roots.

Adventitious roots emerge at a specific location above the site of excision. We tested whether changing auxin maxima from the apical end to basal end of the hypocotyl explants would drive changes in auxin transport and thus location of adventitious root formation. These experiments demonstrate that auxin transport is essential for adventitious root formation and that the polarity of the stem segments is directly tied to the source of auxin and its transport.

199 Results

Auxin polarity can be altered by changing auxin availability

We asked whether the polarity of auxin transport could be reversed in Arabidopsis hypocotyls by changing the location of the auxin supply resulting in altered positioning of adventitious root formation. Hypocotyl explants were prepared by removing the shoot apex and cotyledons and by cutting 0.5-0.75cm of hypocotyls segments. Agar cylinders, containing control agar or agar supplemented with 100 µM IAA was applied to the apical or basal end of the hypocotyl explant. In addition, this experiment was performed with hypocotyl explants in two orientations. Hypocotyl explants were oriented either vertically or inverted and formation and position of adventitious roots were recorded 7 days after treatment, as shown in Figure A-1 and Table A-I. Hypocotyl explants with control agar applied locally did not produce any adventitious roots (A-1A). Application of an IAA containing agar line at the apical end induced adventitious root formation at the basal end of the hypocotyl. But a few roots also formed at the apical end in contact with the IAA containing agar line (A-1A (ii),(iii)). When IAA was applied in similar dose at the apical end, but hypocotyls were placed upside down, there were fewer adventitious roots formed, as shown in Table A-I. This suggests that shoot apex can be replaced by external IAA and that the orientation of the hypocotyl affects the magnitude of adventitious root formation, consistent with basipetal IAA transport mediated delivery of IAA to the hypocotyl base.

Hypocotyl explants treated with IAA applied at the basal end and oriented vertically routinely formed a few adventitious roots at the root end in contact with agar.

200

A

B

Figure A-1: Shifting auxin maxima from apex to base of hypocotyl explant can change the position of adventitious root formation and auxin accumulation.

(A)Hypocotyl explants were treated locally at the apical or basal end with 100µM IAA as indicated by arrow heads. The position and number of adventitious roots were analyzed seven days later. The vertical arrows indicate the direction of gravity. Scale bar is 1mm.

(B) Hypocotyl explants of AtGH3:GUS were treated locally with 100µM IAA and changes in AtGH3:GUS expression was examined after 7 days in GUS stained and

201 cleared hypocotyl explants.; (i): control; (ii), (iii): IAA applied at the apical end; (iv), (v):

IAA applied at the basal end at the apical end, 100µM NPA was applied below the IAA application in (iv). The vertical arrows indicate the direction of gravity. Scale bar is 1mm.

202

Table A-I: Changing local auxin maxima from apical end to basal end

changes the position of adventitious root formation.

IAA in μM Site of Orientation Number of

application adventitious

rootsa

Apex Base

0 Apical end upright 0±0 0±0

100 Apical end upright 1.6±0.34.9±0.4

100 Apical end inverted 0.4±0.23.1±0.3

100 Basal end upright 0.2±0.12.9±0.3

100 Basal end inverted 1.9±0.35.5±0.5

Hypocotyl explants were treated locally at the apical or basal end with

100µM IAA as indicated by arrow heads and position and number of adventitious roots were analyzed 7 days later. Average and standard error of 16-21 seedlings are reported

203 Occasionally, some of the hypocotyls formed adventitious root or primordia at the shoot

end (A-1A(iv)). Hypocotyls with IAA applied at the basal end but with the hypocotyl

explant inverted so that IAA was applied at the top, formed adventitious roots at the

apical end consistent with establishment of a new polarity in this tissue (A-1A(v)). This

suggests that IAA applied locally at the basal end could move towards the shoot end in the acropetal direction, and induce adventitious root formation at the apical end. The

accentuated formation of adventitious roots at the apical end in seedlings with an inverted

orientation suggests that gravity may play a role in accelerating the reversed movement

of IAA.

To confirm that auxin transport is driving adventitious root formation at the shoot

end when applied at the root end, an agar line containing 100µM NPA was applied below

the agar line with 100µM IAA, and plates were oriented vertically or inverted. Most of the hypocotyls treated with NPA produced few if any adventitious roots at the shoot end, as shown in Figure A-1A(vi). (have to repeat the experiment) This suggests that the formation of adventitious roots was as a result of polar auxin transport from the basal end towards the apical end.

Auxin induced GUS expression can be seen during reversal of polarity

To look at changes in auxin accumulation with and without reversal of auxin

transport polarity during adventitious root formation, expression of the AtGH3:GUS

transgene was examined in response to local application of control agar and agar

containing 100µM IAA at the apical or basal end of hypocotyl explants (n =7-13) as

shown in Figure A-1B. None of the AtGH3:GUS hypocotyl explants with control agar at

204 the apical end, showed At GH3:GUS expression. In contrast, 90% of vertically oriented

and 100% of inverted hypocotyls with IAA applied at the apical end to mimic the normal

auxin stream had AtGH3:GUS expression at apical and basal ends. When IAA was

applied at the basal end to induce reversal of polarity, 60% of hypocotyls oriented

vertically showed staining only at the apical end, but when orientation was inverted all

the hypocotyls had GH3-GUS expression in both the apical and basal ends of hypocotyl

explants. All of these experiments are consistent with auxin application at the basal end

of hypocotyl explant driving auxin transport in the reverse or acropetal direction, when

gravity reinforces this polarity of auxin movement.

Acropetal auxin transport in the reverse direction was observed after polarity reversal

We asked whether conditions that reverse the polarity of adventitious root

formation also reverse the polarity of auxin movement. Explants were treated with IAA at

the apical or basal ends. After two days, 3H-IAA transport in both acropetal and basipetal

polarities of the hypocotyls were examined in 3mm sections during a 3 hour transport

assay, as shown in Figure A-2. Hypocotyls that had control agar treatment at the shoot

end exhibited background levels of transport. When the shoot apex was replaced with

IAA, basipetal transport was restored and acropetal IAA transport was low, consistent

with one single basipetal auxin transport stream in hypocotyls. In contrast, if IAA is

applied at the apical end and hypocotyls are inverted, the basipetal transport gets further reduced while acropetal transport remains low. In upright hypocotyl explants with local

IAA treatment given at basal end, had stronger basipetal polarity of transport from the apical end towards basal end with very low amounts of acropetal transport. But when

205

Figure A-2: Acropetal auxin transport can be observed after polarity reversal.

An agar cylinder containing radioactive IAA was applied at the apical or basal end after removing the shoot apex of intact or excised 5 day old low light grown seedlings. 3mm sections from the opposite end were removed after 3hrs and the amount of radioactive

IAA present in these sections were measured using a scintillation counter. Average ± std error is given.

206 IAA was applied locally at the basal end and the hypocotyls were inverted, a higher

amount of acropetal transport from basal end to the apical end was observed in addition

to the basipetal auxin stream suggesting a bidirectional polarity. This result is consistent

with formation of a new polarity of IAA transport, even under conditions where the old

polarity is not totally lost. These polarity movements parallel the adventitious root formation phenotype as adventitious roots formed at the apical end when auxin was locally applied at the basal end with the inversion of hypocotyl explants.

207 Discussion

We asked if the inherent auxin transport polarity of hypocotyls which defines the pattern of adventitious root development, could be reversed by altering the auxin maxima.

Hypocotyl explants were treated with IAA applied locally at either the apical or basal end and the amount of auxin moving in both direction and the number of adventitious roots formed at either end were quantified seven days later. Indeed, the shift of auxin maxima from apical end to basal end induced a reversal in polarity of auxin transport from being basipetal to acropetal as evident from both the direct measurement of IAA transport and the induction of adventitious root emergence from the apical end. The canalization hypothesis of auxin flow proposes that auxin has a positive effect on strengthening its polar transport (Sachs, 1981) and these experiments extend this hypothesis to directly demonstrate that a local auxin maxima can completely reverse the endogenous polarity of a stem that is depleted of the endogenous auxin maxima.

A second reinforcing cue for this reversal of developmental polarity is gravity.

Changing auxin maxima to the basal end of hypocotyl explants induced acropetal transport and adventitious roots formation at the apical end with higher frequency in explants that were inverted. This suggests that gravity reinforced the flow of auxin which drives canalization and leads to the change in developmental polarity resulting in formation of adventitious roots at the apical end. Auxin transport changes in response to gravity are well characterized. Gravity is known to induce lateral movement of auxin, resulting in accumulation of auxin on the lower sides of stems and roots undergoing gravitropic curvature (Muday and Rahman, 2008). This report suggests that local auxin maxima and gravity are reinforcing cues to control auxin transport polarity.

208 Our results repeat and extend a previous study in which auxin was applied to the apex of Tagetes stem segment to locally induced adventitious root formation (Went,

1941). When this segment was planted with the rooted apex below ground, stems showed a reversal of auxin transport polarity when measured three weeks later (Went,

1941). The nodes in these inverted stems expanded and exhibited gravitropic reorientation, but no developmental alterations in polarity were found. In contrast, in young Arabidopsis hypocotyls, we were able to reverse both auxin transport and developmental polarity.

The ability of auxin to regulate its own polar movement as suggested by canalization hypothesis is a fascinating aspect of this hormone. Here we report evidence that local IAA sources can reverse both auxin transport polarity and developmental polarity, as reported by auxin transport measurements and adventitious root formation.

We have uncovered an important role of gravity in canalization flow of auxin. We find that ABCB19 mediated transport is important for adventitious root formation and may be essential for polarity reversal. Using Arabidopsis hypocotyls as a model system we have provided additional evidence in support of the canalization hypothesis showing auxin- dependent changes in auxin transport and adventitious root formation.

209 Methods

Plant growth conditions

To induce reversal of polarity, agar lines with indicated amount of IAA or other compounds were applied locally at either end of root excised hypocotyls after removal of shoots. They were placed in vertical or inverted orientation with shoot apex up or down, respectively under light intensity of 100 μmol m–2 s–1. Localized application of NPA was done as a second agar cylinder below agar cylinder containing IAA. Observations on position and number of emerged adventitious roots were performed after 7 days using a dissecting microscope.

β –Glucuronidase staining

AtGH3:GUS transgenic seedlings were incubated in 2 mM GUS substrate (100 mM sodium phosphate buffer, 0.5% Triton X, 2mM X-gluc salt, 0.5 mM ferricyanide and

0.5mM ferrocyanide) at 37o C for overnight. Samples were then washed with 100 mM sodium phosphate buffer, pH 7 and stored in 95% ethanol. The samples were analyzed for localization of GUS staining using stereomicroscope (details are given below).

Microscopy

Quantification of adventitious roots was done using a dissecting microscope. GFP fluorescence was observed using Zeiss LSM510 fluorescence laser scanning confocal microscope. All images were taken at similar settings using 63X water immersion lens with FITC narrow band filter. Pictures of hypocotyl explants were taken using Epi-

Fluorescent Stereomicroscope (Leica MZ16 FA) and Sony Cyber Shot DSC -505v. All

210 pictures within an experiment were taken under similar settings, unless indicated

otherwise.

Auxin transport measurements in hypocotyl

To measure auxin transport after reversal of polarity, agar lines with indicated

amount of IAA was applied locally at either end of root excised hypocotyls of 5 day old

low light grown seedlings, after removal of shoots. They were placed in vertical or

inverted orientation with shoot apex up or down, respectively and placed under light intensity of 100 μmol m–2 s–1 with yellow filter. After two days, agar lines were replaced

with agar lines containing tritiated IAA and were transferred to dark. After 3hrs, 3mm

sections from either end were taken and quantified using scintillation counter.

211 Literature cited

Muday GK, Rahman A (2008) Auxin transport and the integration of gravitropic

growth. In S Gilroy, P Masson, eds, Plant . Blackwell Publishing,

Oxford, pp 47-78

Paciorek T, Zazimalova E, Ruthardt N, Petrasek J, Stierhof YD, Kleine-Vehn J,

Morris DA, Emans N, Jurgens G, Geldner N, Friml J (2005) Auxin inhibits

endocytosis and promotes its own efflux from cells. Nature 435: 1251-1256

Sachs T (1981) The control of the patterned differentiation of vascular tissues. Adv. Bot.

Res 9: 151-162

Sachs T (1986) Cellular patterns determined by polar transport. In M Bopp, ed, Plant

Growth Substances 1985. Springer-Verlag, Berlin Heidelberg, pp 231-235

Sauer M, Balla J, Luschnig C, Wisniewska J, Reinohl V, Friml J, Benkova E (2007)

Canalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of

PIN polarity (vol 20, pg 2902, 2006). Genes & Development 21: 1431-1431

Sheldrake A (1974) Polarity of auxin transport in inverted cuttings. New Phytologist 73:

637-642

Went F (1941) Polarity of auxin transport in inverted Tagetes cuttings. Botanical Gazette

103: 386-390

212

CURRICULUM VITAE

POORNIMA SUKUMAR

Department of Biology Wake Forest University, Box 7325 Winston-Salem, NC, 27109

Educational Experience:

• 2006-Present Ph.D. (ABD), Grade Point Average: 3.9/4.0 Wake forest University, Winston Salem, NC. Advisor Name: Dr. Gloria K. Muday.

Dissertation: Plant Physiology: Hormonal Regulation of Adventitious Root Formation in Arabidopsis and Tomato.

• 2004-2006 Master of Science in Biology, Grade Point Average: 3.9/4.0 Wake Forest University, Winston-Salem, NC. Advisor Name: Dr. Gloria K. Muday.

Thesis: Role of Auxin Transport in the Photomorphogenic Mutant hy5.

• 1999-2003 Bachelor of Science in Agriculture, Grade Point Average: 9.0/10 (Ranked 1st in the University), Kerala Agricultural University, India.

Research Experience:

• Laboratory experience in plant physiology o Modulation of auxin transport during plant responses to gravity, wounding. o Molecular techniques ( e.g. RT-PCR). • Microscopy techniques: Confocal laser scanning microscope, Epifluoresecent microscope, Compound microscopes, & Stereomicroscope • Biologist in a in-class bioinformatics project aimed at developing a software to identify protein spots in 2 D gels. • Green house assistant for the Department of Biology, Wake Forest University, Winston-Salem. • Field experience growing research tomatoes.

213 • Trained in quantification of free auxin in tissue using GC-Mass Spectrometry in Dr Jerry Cohen’s lab, University of Minnesota, St Paul, Minnesota.

Teaching Experience:

• Teaching assistant: Biochemistry 670: 2009 Fall • Teaching Assistant: Cell Biology 214: 2009 Spring

• Microscopy Teaching Assistant: 2007 Fall • Teaching Assistant: Cell Biology 214: 2006 Fall • Teaching Assistant: Cell Biology 214: 2006 Spring • Teaching Assistant: Biochemistry 670: 2005 Fall • Teaching Assistant: Comparative Physiology 112: 2005 Spring • Teaching Assistant: Comparative Physiology 112: 2004 Fall • Trained undergraduate students in the laboratory during Ph.D. studies-2006- present

BIBILIOGRAPHY

Journal Publications:

• Sukumar P, Muday GK (2010) “Polar auxin transport by MDR1 drives adventitious root formation in Arabidopsis” in preparation. • Negi S*, Sukumar P*, Liu X, Cohen J, Muday GK (2010) "Genetic dissection of the role of ethylene in regulating auxin dependent lateral and adventitious root formation in tomato" Plant Journal 61;3-15. • Chen, Z. Y., Noir, S., Kwaaitaal, M., Hartmann, H. A., Wu, M. J., Mudgil, Y., Sukumar, P., Muday, G., Panstruga, R., and Jones, A. M. J. (2009) "Two seven- transmembrane domain MLO proteins co-function in root thigmomorphogenesis" Plant Cell 21;1972-1991. • Sukumar P*, Edwards KS*, Rahman A, Delong A, Muday GK (2009)" PINOID kinase regulates root gravitropism through modulation of PIN2-dependent basipetal auxin transport in Arabidopsis" Plant Physiology 150(2) 722-735. • Sibout R, Sukumar P, Hettiarachchi C, Holm M, Muday GK, Hardtke CS (2006) "Opposite root growth phenotypes of hy5 versus hy5 hyh mutants correlate with increased constitutive auxin signaling" PLoS Genet 2(11); 1898-191. • Buer CB, Sukumar P, Muday GK (2006)"Ethylene modulates flavonoid accumulation and gravitropic response in roots of Arabidopsis thaliana" Plant Physiology, 140(4);1384–1396. • co-authorship

Poster Abstracts:

214 • Sukumar P and Muday GK (2009) “Ethylene and auxin cross talk regulates adventitious root formation in Arabidopsis and Tomato”, 8th International Conference on Ethylene, Ithaca, NY, USA. • Sukumar P and Muday GK (2009) 'Role of auxin and ethylene in adventitious root formation in Arabidopsis and Tomato', 9th Annual Graduate Student research day, Wake Forest University, NC, USA. • Sukumar P and Muday GK (2008) "Polar auxin transport drives adventitious root formation", 22nd Annual Plant Molecular Biology Meeting, Asheville, NC, USA. • Sukumar P and Muday GK (2008) “Role of auxin and ethylene in adventitious root formation in Arabidopsis and Tomato” American Society of Plant Biologists, Merida, Mexico. • Sukumar P and Muday GK (2008) “Role of auxin and ethylene in adventitious root formation in Arabidopsis”, 8th Annual Graduate Student Research Day, Wake Forest University, NC, USA • Sukumar P and Muday GK (2007) “Role of auxin and ethylene in adventitious root formation in Arabidopsis” 21st Annual Plant Molecular Biology Retreat, Wilmington, NC, USA. • Sukumar P and Muday GK (2007) "Role of auxin and ethylene in adventitious root formation in Arabidopsis” American Society of Plant Biologists, Chicago, Illinois, USA. • Sukumar P and Muday GK (2006) “Role of auxin and ethylene in adventitious root formation in Arabidopsis”, FASEB, Vermont, USA. • Barnard R, Kolb B, Scott W, Sukumar P, Olex A (2006) 'Bioinformatics: Protein spot identification tool, 6th Annual Graduate Student Research Day, Wake Forest University, NC,USA. • Sukumar P, Hardtke CS, Muday GK (2006) “Defects in gravity response and lateral root growth in hy5 are flavonoid independent”, 6th Annual Graduate Student Research Day, Wake Forest University, NC, USA. • Sukumar P, Hardtke CS, Muday GK (2005)“Defects in gravity response and lateral root growth in hy5 are flavonoid independent” 19th Annual Plant Molecular Biology Retreat, Willmington, NC, USA. • Sukumar P, Hardtke CS, Muday GK (2005) 'Defects in gravity response and lateral root growth in hy5 are flavonoid independent' 5th Annual Graduate Student Research Day, Wake Forest University, NC, USA.

Conferences:

• 8th International Conference on Ethylene 2009 from 21st to 25th June in Ithaca, New York and presented a poster-“Ethylene and auxin cross talk regulates adventitious root formation in Arabidopsis and Tomato”. • Annual Graduate Student Research day, 6th April 2009, Wake Forest University, NC, and presented a poster – “Role of auxin and ethylene in adventitious root formation in Arabidopsis and Tomato”. • Perspectives in Biology Symposium 2008, 14th Nov, Wake Forest University, NC, poster- “Role of auxin and ethylene in adventitious root formation in Arabidopsis”.

215 • Annual 22nd Plant Molecular Biology Retreat 2008, 26th to 28th Septemeber, Asheville, NC, USA. • American Society of Plant Biologists 26th to 30th June 2008 plant biology meeting in Merida, Mexico, presented a poster- “Role of auxin and ethylene in adventitious root formation in Arabidopsis and Tomato”. • Annual Graduate Student Research day, 5th March 2008, and presented a poster- “Role of auxin and ethylene in adventitious root formation in Arabidopsis”. • Annual 21st Plant Molecular Biology Retreat 28th to 30th Sep 2007, and presented a poster- “Role of auxin and ethylene in adventitious root formation in Arabidopsis”. • American Society of Plant Biologists 2007 Plant Biology meeting in Chicago and presented a poster- “Role of auxin and ethylene in adventitious root formation in Arabidopsis”. • Perspectives in Biology Symposium 2006, 10th-11th Nov, Department of Biology, WFU. • FASEB 2006 conference on Mechanisms of plant development held in Vermont, Aug 5th to 9th and presented a poster- “Role of auxin and ethylene in adventitious root formation in Arabidopsis”. • Sixth Annual Graduate Student Research Day, 24th March 2006, Wake forest University, Winston-Salem, NC, and presented posters-“Bioinformatics: Protein spot identification tool” and “ Defects in gravity response and lateral root growth in hy5 are flavonoids independent”. • 19th Annual Plant Molecular Biology Retreat from Sep 30th to Oct 2nd 2005 and presented a poster-“Defects in gravity response and lateral root growth in hy5 are flavonoid independent”.

Talks:

• “Adventitious root formation: Unraveling hormonal cross talk’, Departmental seminar, Department of Biology, Wake Forest University, Winston-Salem, NC, March 31st, 2010 • “Polar auxin transport drives adventitious root formation”, Annual 22nd Plant Molecular Biology Retreat 2008, Asheville, NC - 26th-28th of September, 2008. • “Role of flavonoids during gravity response and root formation in Arabidopsis”, Departmental seminar, Department of Biology, Wake Forest University, Winston- Salem, NC, 4th April, 2006.

Awards & Honors

• Tuttle-Newhall Travel Fund, 2009- to attend 8th International Conference on plant hormone ethylene in Ithaca, NY. • Elton C. Cocke Travel Fund, 2008 to attend ASPB 2008 meeting in Merida, Mexico. • 1st place in poster competition- 8th Annual Graduate Student Research Day, 2008.

216 • Vecellio Fund, Department of Biology, 2008-to meet expenses to work in Dr Jerry Cohen’s lab in University of Minnesota. • Elton C. Cocke Travel Fund, 2007- to attend ASPB 2007 meeting in Chicago. • Vecellio Fund, Department of Biology, 2007- to attend ASPB 2007 meeting in Chicago. • Wake Forest Alumni Travel award, 2006 - to attend FASEB meeting in Vermont. • Indian Council of Agricultural Research (ICAR) Merit Scholarship (Based on Grade Point Average). • Kerala Agricultural University Merit Scholarship: Based on CBSE % marks (High School). • Kochi Refineries Limited Scholarship (Won by students who get into professional programs in Universities, directly from high school). • Duke of Edinburg: Bronze Medal for Extracurricular activities.

Professional Development Activities

• Attend the Cell and Molecular Biology lunch group at Department of Biology, which discusses molecular and cell biolgy research, 2006-present. • Attend relevant bioinformatics meetings at Department of Computer scicence, Wake Forest University, 2007-present. • Member of American Society of Plant Biologists, 2007-present. • Member of Wake Forest University Graduate Student Association, 2004-present.

Selected Courses:

PhD & Masters: • Teaching Skills and Instructor Devlopment • Biochemistry • Molecular Biology • Microscopy • Statistics: Research design and Analysis I • Bioinformatics

Bachelors Degree: • Molecular Biology, • Biotechnology-I, Biotechnology-II • Anatomy, Embryology • Cytology, • Principles of Genetics • Crop Physiology • Microbiology-I & II • Agricultural Biochemistry

217