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Internet-Oheis Aineiston Taulukko. Valon Indusoimien Ja INTERNET-OHEIS AINEISTON TAULUKKO. Valon indusoimien ja kellokoneiston avainmolekyylien yhteydet sairauksiin. Geeni Eläinmallin ilmiasu Ihmisen sairaus Homer1 Masennus [1] ? Psykoosi [2] Oppimishäiriöt [3] Dementia [4] Nr4a1 Apoptoosin häiriöt [5] Masennus [26] Ylivilkkaus [6] Kaksisuuntainen mielialahäiriö [27] Sokeriaineenvaihdunnan häiriöt [7] Psykoosi [27] Ateroskleroosi [8] Akuutti myelooinen leukemia [28] Dementia [4] Rintasyöpä [29] Eturauhassyöpä [30] Melanooma [31] Alzheimerin tauti [32] Ateroskleroosi [33] Arntl1 Hedelmättömyys [9] Kaamosmasennus [34] Sokeriaineenvaihdunnan häiriöt [10] Kaksisuuntainen mielialahäiriö [35] Rasva-aineenvaihdunnan häiriöt [11] Verenpainetauti [36] Unihäiriöt [12] Tyypin 2 diabetes [36] Artropatia [13] Krooninen myelooinen leukemia [37] Sisäisen kellon arytmia [14] Clock Mania [15] Unihäiriöt [38] Metabolinen oireyhtymä [16] Metabolinen oireyhtymä [39] Kokaiiniriippuvuus [17] Lihavuus [39, 40] Rasvamaksa [41] Psykoosi [42] Npas2 Sisäisen kellon joustamattomuus [18] Kaamosmasennus [34] Muistihäiriöt [19] Non-Hodgkin-lymfooma [43] Rintasyöpä [44] Eturauhassyöpä [45] Autismi [46] Per1 Glukokortikoidituotannon häiriöt [20] Rintasyöpä [47,48] Ei-pienisoluinen keuhkosyöpä [49] Kohtusyöpä [50] Haimasyöpä [51] Krooninen myelooinen leukemia [37] Autismi [46] Per2 Alkoholin suurkulutus [21] Kaamosmasennus [34] Pahanlaatuinen lymfooma [22] Aikaistuneen univaiheen oireyhtymä [52] Endoteelin toimintahäiriöt [23] Akuutti myelooinen leukemia [53] Krooninen myelooinen leukemia [37] Rintasyöpä [47] Cry1, Cry2 Unihäiriöt [24] Krooninen myelooinen leukemia [37] Sokeriaineenvaihdunnan häiriöt [25] Eturauhassyöpä [45] 42 INTERNET-OHEISAINEISTON LÄHTEET 14) Bunger M, Wilsbacher L,Moran S, ym. receptors Nr4a3 and Nr4a1 leads to de- 1) Orsetti M, Di Brisco F, Canonico PL, Mop3 is an essential component of the velopment of acute myeloid leukemia. Genazzani AA, Ghi P. Gene regulation master circadian pacemaker in mam- Nat Med 2007;13:730–5. in the frontal cortex of rats exposed to mals. Cell 200;103:1009–17. 29) Pärssinen J, Alarmo EL, Khan S, Karhu the chronic mild stress paradigm, an 15) Roybal K, Theobold D, Graham A, ym. R, Vihinen M, Kallioniemi A. Identifica- animal model of human depression. Mania-like behavior induced by disrup- tion of differentially expressed genes Eur J Neurosci 2008;27:2156–64. tion of CLOCK. Proc Natl Acad Sci U S A after PPM1D silencing in breast cancer. 2) Szumlinski KK, Lominac KD, Kleschen 2007;104:6406–1. Cancer Lett 2008;259:61–70. MJ, ym. Behavioral and neurochemical 16) Turek FW, Joshu C, Kohsaka A, ym. 30) Tamura K, Furihata M, Tsunoda T, ym. phenotyping of Homer1 mutant mice: Obesity and metabolic syndrome in Molecular features of hormone-refrac- possible relevance to schizophrenia. circadian Clock mutant mice. Science tory prostate cancer cells by genome- Genes Brain Behav 2005;4:273–88. 2005;308:1043–5. wide gene expression profiles. Cancer 3) Jaubert PJ, Golub MS, Lo YY, Ger- 17) McClung CA, Sidiropoulou K, Vitaterna Res 2007;67:5117–25. mann SL, ym. Complex, multimodal M, Takahashi JS, White FJ, Cooper DC, 31) Yu H, Kumar SM, Fang D, Acs G, Xu behavioral profile of the Homer1 Nestler EJ. Regulation of dopaminer- X. Nuclear orphan receptor TR3/Nur77 knockout mouse. Genes Brain Behav gic transmission and cocaine reward mediates melanoma cell apoptosis. 2007;6:141–54. by the Clock gene. Proc Natl Acad Sci Cancer Biol Ther 2007;6:405–12. 4) Dickey CA, Loring JF, Montgomery J, U S A 2005;102:9377–8. 32) Newman SJ, Bond B, Crook B, Darker Gordon MN, Eastman PS, Morgan 18) Dudley CA, Erbel-Sieler C, Estill SJ, ym. J, Edge C, Maycox PR. Neuron-specific D. Selectively reduced expression of Altered patterns of sleep and behav- localisation of the TR3 death recep- synaptic plasticity-related genes in ioral adaptability in NPAS2-deficient tor in Alzheimer’s disease. Brain Res amyloid precursor protein + preseni- mice. Science 2003;301;379–83. 2000;857:131–40. lin-1 transgenic mice. J Neurosci. 2003 19) Garcia JA, Zhang D, Estill SJ, ym. Im- 33) Bonta PI, van Tiel CM, Vos M, ym. Nu- 15;23:5219–26. paired cued and contextual memory clear receptors Nur77, Nurr1, and NOR- 5) Kim S, Ono K, Tobias P, Han, J. Orphan in NPAS2-deficient mice. Science 1 expressed in atherosclerotic lesion nuclear receptor Nur77 is involved in 2000;288:2226–30. macrophages reduce lipid loading and caspase-independent macrophage cell 20) Dallmann R, Touma C, Palme R, Albre- inflammatory responses. Arterioscler death. J Exp Med 2003;197:1441–52. cht U, Steinlechner S. 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Proc Natl Acad Sci changes are sensitive to agonal-pH abolic syndrome in man. Int J Obes U S A 2005;102:12071–6. state: implications for brain disorders. 2008;32:658–62. 12) Laposky A, Easton A, Dugovic C, Wal- Mol Psychiatry 2006;11:663–79. 40) Sookoian S, Gemma C, Gianotti TF, isser J, Bradfield C, Turek F. Deletion of 27) Xing G, Zhang L, Russell S, Post R. Burgueño A, Castaño G, Pirola CJ. Ge- the mammalian circadian clock gene Reduction of dopamine-related tran- netic variants of clock transcription BMAL1/Mop3 alters baseline sleep scription factors Nurr1 and NGFI-B in factor are associated with individual architecture and the response to sleep the prefrontal cortex in schizophrenia susceptibility to obesity. Am J Clin Nutr deprivation. Sleep 2005;28:395–409. and bipolar disorders. 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