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Dcr3/Fc Chimera, Human (D2441)

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Dcr3/Fc Chimera, Human (D2441) DcR3/Fc Chimera, human recombinant, expressed in Sf 21 cells Catalog Number D2441 Storage Temperature -20 °C Product Description Preparation Instructions Decoy Receptor 3 (DcR3) is produced from a DNA Reconstitute the contents of the vial using sterile sequence encoding the signal peptide from human phosphate buffered saline containing at least 0.1% CD33 joined with amino acid residues 24-300 of human human serum albumin or bovine serum albumin. DcR31 fused to the Fc region of human IgG1 by a Prepare a stock solution of no less than 10 mg/mL. polypeptide linker. The reduced human DcR3/Fc monomer has a calculated molecular mass of 57 kDa. Precautions and Disclaimer Due to glycosylation, the recombinant protein migrates This product is for R&D use only, not for drug, as a 60-65 kDa protein in SDS-PAGE under reducing household, or other uses. Please consult the Material conditions. Based on N-terminal sequencing, the Safety Data Sheet for information regarding hazards protein has Val24 at the N-terminus. DcR3 shares and safe handling practices. amino acid sequence homology with osteoprotegerin (31%), TNFRII (29%), and Fas (17%). Storage/Stability Store at -20 °C. Upon reconstitution, the product may Apoptosis, or programmed cell death, is induced in cells be stored at 2-8 °C for up to one month. For extended by a group of death domain-containing receptors storage, freeze in working aliquots at -20 °C. Repeated including TNFR1, Fas, DR3, DR4, and DR5. Binding of freezing and thawing, or storage in a “frost-free” ligand to these receptors sends signals that activate freezers, is not recommended. members of the caspase family of proteases. The signals ultimately cause the degradation of Product Profile chromosomal DNA by activating DNase. Recombinant human DcR3/Fc Chimera is measured by its ability to inhibit the biological activity of Fas-ligand Two decoy receptors, DcR1 and DcR2, were found to induced apoptosis of Jurkat cells.4 compete with DR4 and DR5 for their ligand TRAIL binding. Another decoy receptor was later discovered The ED is defined as the effective concentration of 1, 2 50 and designated DcR3. Decoy Receptor 3 (DcR3), growth factor that elicits a 50% increase in cell growth also called TNFRSF6B, TR6, and M68, is a member of in a cell based bioassay. the TNF receptor superfamily. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated Purity: > 90% (SDS-PAGE) molecule. DcR3 binds to FasL and LIGHT and inhibits 1, 2 FasL and LIGHT induced apoptosis. Endotoxin level: < 1 EU/mg cytokine as determined by the LAL (Limulus amebocyte lysate) method. The DcR3 transcript is expressed in normal tissues and highly-expressed in malignant tumors, e.g., lung and 3 References colon carcinomas. 1. Pitti, R.M., et al., Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Reagent Nature, 396, 699-703 (1998). Supplied as a lyophilized powder from a 0.2 mm filtered 2. Yu, K.Y., et al., A newly identified member of tumor solution in phosphate buffered saline. necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J. Biol. Chem., 274, 13733-13739 (1999). 3. Bai, C., et al., Overexpression of M68/DcR3 in 4. Cheng, J., et al., Protection from Fas-mediated human gastrointestinal tract tumors independent of apoptosis by a soluble form of the Fas molecule. gene amplification and its location in a four-gene Science, 263, 1759-1762 (1994). cluster. Proc. Natl. Acad. Sci. USA, 97, 1230-1235 (2000). KAA,PHC 04/07-1 Sigma brand products are sold through Sigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side of the invoice or packing slip..
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