DOCSLIB.ORG

July 1 2017 Annual Scientific Meeting

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
July 1 2017 Annual Scientific Meeting Undersea & Hyperbaric Medical Society’s 2017 ANNUAL SCIENTIFIC MEETING 2017 Annual Scientific Meeting June 29 – July 1 Pre-courses: June 28 / Post-course: July 2 Wound Care Education Partners NAPLES GRANDE BEACH RESORT, NAPLES, FLORIDA Wednesday, June 28: How to Prepare for Accreditation: Royal Palm Ballroom I Hyperbaric Oxygen Safety: Clinical and Technical Issues: Royal Palm Ballroom II Management of DCI in the Field and Development of Best Practice: Royal Palm Ballroom III Welcome Reception: Mangrove Pool side Thursday, June 29: Exhibits: Orchid Ballroom Posters: Royal Palm Foyer General Session: Royal Palm IV-VIII Non-Physician Breakout Session: Royal Palm I-III Friday, June 30: Exhibits: Orchid Ballroom Posters: Royal Palm Foyer General Session: Royal Palm IV-VIII Saturday, July 1: Exhibits: Orchid Ballroom Posters: Royal Palm Foyer General Session: Royal Palm IV-VIII Sunday, July 2: Reimbursement Rollercoaster: Acacia 4-6 Surveyor Training: Acacia 1-3 UHMS Annual Scientific Meeting * June 29-July 1, 2017 * Naples, Florida 2 TABLE OF CONTENTS Subject Page No. UHMS Committee Leadership Listing .......................................................................................................................... 4 Schedules Pre-Courses .................................................................................................................................................. 5-6 Non-Physician Breakout Track ..................................................................................................................... 6-7 General Session ........................................................................................................................................... 7-8 Abstract Schedule ...................................................................................................................................... 8-15 Post-Courses ................................................................................................................................................. 16 Committee Meetings ............................................................................................................................... 17-18 Continuing Education ........................................................................................................................................... 19-20 Evaluation / MOC Credit Information ........................................................................................................................ 21 Disclosures ............................................................................................................................................................ 22-26 Exhibitors .............................................................................................................................................................. 27-29 SESSIONS/ABSTRACTS THURSDAY GENERAL SESSION ................................................................................................................. 30-55 PRESIDENT’S ADDRESS ..................................................................................................................................... 31 PLENARY: “The History of the Undersea and Hyperbaric Medical Society (1967-2017)” .......................... 32-33 SESSION A: Diving/Decompression Illness: Theory & Mechanisms ............................................................ 34-44 LAMBERTSEN MEMORIAL LECTURE: “Arterial Gas Embolism” ................................................................... 45-46 SESSION B: HBO2 Therapy Mechanisms ...................................................................................................... 47-54 PLENARY: “HBO2 for Mild Traumatic Brain Injury” .......................................................................................... 55 FRIDAY GENERAL SESSION ................................................................................................................. 56-104 EXECUTIVE DIRECTOR’S ADDRESS ................................................................................................................... 57 PLENARY: “An update on the UHMS Clinical Practice Guidelines”.................................................................. 58 SESSION C: Clinical HBO2 Therapy .............................................................................................................. 59-79 KINDWALL MEMORIAL LECTURE: “Beams and Bars: Radiation Oncology and Hyperbaric Medicine, an Inseparable Story, Past, Present and Future” ....................................................................................... 80-82 SESSION D: Diving & Decompression Illness ............................................................................................. 83-103 PLENARY: “Emergency and Critical Care Hyperbaric Medicine: A Lost Art” .................................................. 104 SATURDAY GENERAL SESSION ........................................................................................................... 105-147 PLENARY: “International Perspectives on Hyperbaric Oxygen Therapy” ............................................... 106-107 SESSION E: HBO2 Therapy, Chambers & Equipment .............................................................................. 108-125 PLENARY: “New Pearls of Wisdom in the Diving and Hyperbaric Medicine Literature” ............................... 126 SESSION F: Clinical and Diving-Related HBO2 Therapy ........................................................................... 127-146 PLENARY: “A Futurist’s Guide to Undersea and Hyperbaric Medicine: Where will we be in another 50 years?” ................................................................................................................................................ 147 Author Abstract Index ....................................................................................................................................... 148-150 2018 Annual Meeting: Save the Date ...................................................................................................................... 150 UHMS Annual Scientific Meeting * June 29-July 1, 2017 * Naples, Florida 3 Undersea & Hyperbaric Medical Society Committees Board of Directors Enrico Camporesi: 2000-2002 Enoch Huang, President Neil Hampson: 2002-2004 James Holm, Immediate Past President Lindell K. Weaver: 2004-2006 John Feldmeier, Past President Bret Stolp: 2006-2008 Nicholas Bird, President Elect/Secretary Laurie Gesell: 2008-2010 Gerardo Bosco, Vice President Brett Hart: 2010-2012 Laurie Gesell, Treasurer John Feldmeier: 2012-2014 Matt Schweyer, Associates Technician Representative James Holm: 2014-2016 Richard “Gus” Gustavson: Associates Nurse Representative John Peters, UHMS Executive Director (non-voting) Committee Chairpersons -Members at Large- Awards: Gerardo Bosco 2017: John Freiberger Accreditation Council: Brett Hart 2018: Tracy LeGros Associates Council: Matt Schweyer & Gus Gustavson 2019: Sandra Wainwright Chapter/Affiliate Committee: Nick Bird DCI & Adjunctive Therapy: Richard Moon 2017 Organizing & Scientific Program Committee Diving: Tony Alleman Enoch Huang Education: Heather Murphy-Lavoie Jim Holm FUHM: James Holm John Feldmeier Finance/Audit: Laurie Gesell Laurie Gesell QUARC: Caroline Fife/Helen Gelly/Marc Robins Bruce Derrick Hyperbaric Oxygen Therapy: Richard Moon Stephen Thom Membership: Nick Bird Sandra Wainwright Nominations: Nick Bird Nick Bird Publications: Marvin Heyboer Gus Gustavson, Associates Program Research: John Kirby Matt Schweyer, Associates Program Safety: Jim Bell Heather Murphy-Lavoie, CME Representative CPG Committee: Enoch Huang Lisa Tidd, Meeting Planner GME Committee: Enoch Huang Stacy Rupert, CME Coordinator Library: Dick Vann Materials Testing (Ad Hoc): Richard Barry 2017 ASM Staff AMA Liaison: Laurie Gesell Tom Workman Renée Duncan Chapter Presidents Cinda Hart Gulf Coast: Kevin “Kip” Posey Sherrill White-Wolfe Mid-West: Kristen Torgerson Dawn Salka Northeast: Scott Gorenstein Beth Hands Pacific: Ray Barrett Past Presidents Christian J. Lambertsen: 1967-1968 Affiliates Robert D. Workman: 1968-1969 Canadian Undersea and Hyperbaric Medical Association (CUHMA) Edward L. Beckman: 1969-1970 European Underwater and Baromedical Society (EUBS) Heinz R. Schreiner: 1970-1971 Sociedade Brasileira de Medicina Hiperbárica (SBMH) Earl H. Ninow: 1971-1972 Società Italiana di Medicina Subacquea ed Iperbarica (SIMSI) David H. Elliott: 1972-1973 South Pacific Underwater Medicine Society (SPUMS) Johannes A. Kylstra: 1973-1974 Dennis N. Walder, 1974-1975 Peter B. Bennett: 1975-1976 Arthur J. Bachrach: 1976-1977 James Vorosmarti, Jr.: 1977-1978 Herbert A. Saltzman: 1978-1979 Jefferson C. Davis: 1979-1980 Paul Webb: 1980-1981 Eric P. Kindwall: 1981-1982 John Hallenbeck: 1982-1983 Alfred A. Bove: 1983-1984 Paul G. Linaweaver: 1984-1985 Mark E. Bradley: 1985-1986 Joseph C. Farmer: 1986-1987 George B. Hart: 1987-1988 Richard D. Heimbach: 1988-1989 Tom S. Neuman: 1989-1990 Paul J. Sheffield: 1990-1991 Paul Cianci: 1991-1992 Jon T. Mader: 1992-1993 James M. Clark: 1993-1994 Richard E. Moon: 1994-1996 Stephen R. Thom: 1996-1998 Caroline Fife: 1998-2000 UHMS Annual Scientific Meeting * June 29-July 1, 2017 * Naples, Florida 4 SCHEDULES PRE-COURSES: WEDNESDAY, JUNE 28 Pre-Course: Pre-hospital Management of Pre-Course: Pre-Course: Decompression Illness: Towards How to Prepare for Hyperbaric Oxygen Safety: Development of Definitive TIME Accreditation Clinical and Technical Issues TIME Modern
Load more

Recommended publications
  • ANZHMG) & the Hyperbaric Technicians and Nurses Association (HTNA)
    The Australian and New Zealand Hyperbaric Medicine Group (ANZHMG) & The Hyperbaric Technicians and Nurses Association (HTNA) COVID-19 Guidelines 1 | ANZHMG/HTNA COVID - 19 v1.1 2020 - 03- 27 Published by the South Pacific Underwater Medicine Society (SPUMS), c/- Australian and New Zealand College of Anaesthetists (ANZCA), 630 St Kilda Road, Melbourne VIC 3004, Australia. E-mail: [email protected] Website: spums.org.au This document is based upon the Australian and New Zealand Intensive Care Society (2020) ANZICS COVID-19 Guidelines. Melbourne: ANZICS, with permission. THE ANZHMG/HTNA COVID-19 Working Group gratefully acknowledge the kindness of the Australian & New Zealand Intensive Care Society in permitting the use of their guidelines as a template for our own. © Australian and New Zealand Hyperbaric Medicine Group 2020. Not for sale. This work may be reproduced, free of charge, in whole or in part for clinical, study, training, research or any other fair purpose, subject to the inclusion of an acknowledgment of the source. SPUMS requests that you attribute this publication (and any material sourced from it) using the following citation: Australian and New Zealand Hyperbaric Medicine Group and the Hyperbaric Technicians and Nurses Association (2020), ANZHMG/HTNA COVID-19 Guidelines. Melbourne: SPUMS. Disclaimer The Australian and New Zealand Hyperbaric Medicine Group (ANZHMG) and Hyperbaric Technicians and Nurses Association (HTNA) COVID-19 Guidelines have been developed to assist hyperbaric clinicians prepare and plan for the maintenance of hyperbaric services during a pandemic, and provide a safe working environment for staff and patients. Considerable effort has been made to ensure the information contained within the recommendations is correct at the time of publication.
    [Show full text]
  • Nursing in a Critical Care Hyperbaric Unit at Merida, Yucatan, Mexico: Report of a Case of an Acute Pediatric Burn Patient
    Case Report Page 1 of 6 Nursing in a critical care hyperbaric unit at Merida, Yucatan, Mexico: report of a case of an acute pediatric burn patient Judith Ruiz-Aguilar, Rodrigo Diaz-Ibañez, E. Cuauhtemoc Sanchez-Rodriguez Hyperbaric Medicine Service, Hospital Centro de Especialidades Médicas del Sureste (CEM) and Hospital Agustín O’Horan, Merida, Yucatan, Mexico Correspondence to: Judith Ruiz-Aguilar, RN, MEd. Chief of Nursing, Hyperbaric Medicine Service, Hospital Centro de Especialidades Médicas del Sureste (CEM) and Hospital Agustín O’Horan, Merida, Yucatan, Mexico. Email: [email protected]. Abstract: Hyperbaric oxygen therapy (HBOT) for intensive care unit (ICU) patients places special technical and knowledge-based skills demands on nurses inside hyperbaric chambers. Probably the best clinical contributions of HBOT are in the acute cases, in the ischemia reperfusion injury. Nevertheless in the last years, hyperbaric units have focused more in chronic wounds. The first golden rule to treat an ICU patient in a hyperbaric chamber is that you can maintain the same quality of care inside the chamber as in the ICU. This means that the hyperbaric unit has to have the technology means as well as the proficiency and competency of its personnel to provide intensive care inside the chamber. These require competent nursing personnel. We present a case of a 5-year-old pediatric patient who suffered a deep second-degree thermal burn that compromised 32% of the total body surface; including the face, neck, thorax and both arms. The patient received medical support, HBOT and daily wound care. He received a total of 14 treatments and underwent complete healing of the burned areas.
    [Show full text]
  • Safety Manual Program/Monthly Safety Awearness
    2014 Safety Manual/Monthly Safety Awareness Program Serena Group Hyperbaric Medicine Centers Page 1 Confidential and Proprietary Information SerenaGroup Hyperbaric Medical Center Do not copy or distribute 2014 Fire Safety Plan 1. Purpose To provide hyperbaric personnel a predetermined plan in the event of a fire in the hyperbaric area in order to reduce injury and/or catastrophic outcomes. 2. Policy 2.1. In the event of an emergency, the Hyperbaric Medicine Center personnel will be prepared to respond. 2.2. The Safety Director shall be designated by the Program Director / Manager or designee. NOTE: NFPA 99 Health Care Facilities, 1999 edition, (page 131) “19-3.1.3.2 A safety director shall be designated in charge of all hyperbaric equipment. The safety director shall work closely with facility management personnel and the hyperbaric physician(s) to establish procedures for safe operation and maintenance of the hyperbaric facility. He or she shall make necessary recommendations for departmental safety policies and procedures. The safety director shall have the authority to restrict or remove any potentially hazardous supply or equipment items from the chamber.” 2.3. Each plan shall be collaboratively developed with the hospital fire safety policy in conjunction with NFPA standards. 2.4. There will be no smoking or open flames in the hyperbaric area. 2.5. The area will be kept exceptionally clean and free of fire hazards according to the NGPA for Hyperbaric health care facilities. 2.6. The chamber itself will be kept exceptionally clean of lint and dust particles as these are hazardous when inside the chamber.
    [Show full text]
  • (ANZHMG) & the Hyperbaric Technicians and Nurses Association
    The Australian and New Zealand Hyperbaric Medicine Group (ANZHMG) & The Hyperbaric Technicians and Nurses Association (HTNA) COVID-19 Guidelines 1 | ANZHMG/HTNA COVID - 19 v1.1 2020 - 03- 27 Published by the South Pacific Underwater Medicine Society (SPUMS), c/- Australian and New Zealand College of Anaesthetists (ANZCA), 630 St Kilda Road, Melbourne VIC 3004, Australia. E-mail: [email protected] Website: spums.org.au This document is based upon the Australian and New Zealand Intensive Care Society (2020) ANZICS COVID-19 Guidelines. Melbourne: ANZICS, with permission. THE ANZHMG/HTNA COVID-19 Working Group gratefully acknowledge the kindness of the Australian & New Zealand Intensive Care Society in permitting the use of their guidelines as a template for our own. © Australian and New Zealand Hyperbaric Medicine Group 2020. Not for sale. This work may be reproduced, free of charge, in whole or in part for clinical, study, training, research or any other fair purpose, subject to the inclusion of an acknowledgment of the source. SPUMS requests that you attribute this publication (and any material sourced from it) using the following citation: Australian and New Zealand Hyperbaric Medicine Group and the Hyperbaric Technicians and Nurses Association (2020), ANZHMG/HTNA COVID-19 Guidelines. Melbourne: SPUMS. Disclaimer The Australian and New Zealand Hyperbaric Medicine Group (ANZHMG) and Hyperbaric Technicians and Nurses Association (HTNA) COVID-19 Guidelines have been developed to assist hyperbaric clinicians prepare and plan for the maintenance of hyperbaric services during a pandemic, and provide a safe working environment for staff and patients. Considerable effort has been made to ensure the information contained within the recommendations is correct at the time of publication.
    [Show full text]
  • California Halibut Scaled Management Webinar #1 Group
    Exploring Scaled Management for the California Halibut Fishery Webinar #1: A Focused Discussion for the Recreational Sector Thursday, August 12, 2021 | 4:00 PM - 6:00 PM PDT Small Group Discussion Notes Room 1: Commercial Passenger Fishing Vessel (CPFV) Owners and Operators Participants: - Tim Klassen, Eureka, CPFV owner (six pack), fish Humbolt Bay area mostly, vessel is “Reel Steel” - Sean Anderson, professor, study fishing behavior and what types of seafood are available in coastal ports in CA, likes to spear fish - Eddie Tavasieff, commercial H&L fishermen, San francisco area - Surprised that not many CPFV here, want to be fly on the wall and listen and prepare for the commercial discussion - Santos, CDFW LED, Monterey Bay area - Kristine Lesyna, CDFW - Chuck Valle, CDFW - Sara Shen, Strategic Earth How does California halibut contribute to your personal livelihood? - Tim: Halibut fishing inside Humboldt Bay offers fishing opportunity when there’s rough weather on the ocean - Rough ocean conditions in Humboldt, only able to fish 9 days in the ocean this May bc of weather - Can fish inside calmer Humboldt bay when can’t fish on ocean for other sps like salmon or rockfish - Not many fishery options other than CA halibut inside humboldt bay; we have leopard sharks and bat rays but not another fishery that folks fish on a regular basis so if rough weather then really can’t fish anything - Humboldt bay does not have a consistent CA halibut fishery; halibut would be even more important to personal livelihood if it was consistent - get one large age class, come into bay in May/June and they leave in Nov - May get almost all shorts for a year and then the next year get a mix of shorts/legal and then next year mostly legals but starting to be heavily impacted by fishing pressure, another year or two diminished and not a reliable fishery - Another year class comes and cycle begins again, not sure why this happens? - In last 30 years, seen 3 cycles of good fishing for a few years and then it’s over.
    [Show full text]
  • Theory and Treatment Solo Cave Diving
    Decompression Sickness: Theory and Treatment Solo Cave Diving: Just How Safe Is It? A Few Words About Decompression Schedules Cave Diving Into The Dominican Past Diving Pioneers & Innovators: A Series of In Depth Interviews (Dick Bonin) Issue 8 – September 2012 Contents Editorial Editorial 2 Welcome to the eighth issue of Tech Diving Mag. In this issue, the contributors have, once more, brought together a wealth Decompression Sickness: Theory and Treatment of information, along with some distinctive first hand experiences. The By Bret Gilliam 3 contributors for this issue are world renowned industry professional Bret Gilliam, accomplished diver, instructor trainer and book author Steve Lewis, technical diving instructor Peter Buzzacott (PhD) and Solo Cave Diving: Just How Safe Is It? cave explorer Cristian Pittaro. Get to know more about them and read By Peter Buzzacott 22 their bio at www.techdivingmag.com/contributors.html. As you might know, Tech Diving Mag is based on article contribution A Few Words About Decompression Schedules from the readership. So you’re always welcome to drop me a line if you’re interested in volunteering an article. One more much appreciated By Steve Lewis 29 thing is your photos (even without articles)! For submission guidelines, take a look at www.techdivingmag.com/guidelines.html. Cave Diving Into The Dominican Past Tech Diving Mag is very much your magazine and I am always keen By Cristian Pittaro 37 to have your input. If you want to share your views, drop me a line at [email protected]. Diving Pioneers & Innovators: A Series of In Please visit www.techdivingmag.com/communicate.html to subscribe Depth Interviews (Dick Bonin) to the newsletter in order to be notified when new issues are available for download.
    [Show full text]
  • June 18-20, 2015 Annual Scientific Meeting
    UNDERSEA & HYPERBARIC MEDICAL SOCIETY ANNUAL SCIENTIFIC MEETING HOTEL BONAVENTURE MONTREAL, CANADA JUNE 18-20, 2015 2015 UHMS Scientific Meeting June 18-20 Montreal, Canada TABLE OF CONTENTS Subject Page No. Disclosures ................................................................................................................................................................ 6-7 Schedule .................................................................................................................................................................. 8-13 Continuing Education ................................................................................................................................................ 13 Associates’ Breakout Schedule .................................................................................................................................. 14 Evaluation / MOC Credit Information ....................................................................................................................... 15 Committee Meetings .................................................................................................................................................. 16 Exhibitors .............................................................................................................................................................. 17-20 SESSIONS/ABSTRACTS THURSDAY GENERAL SESSION .............................................................................................................. 22-63 PRESIDENT’S
    [Show full text]
  • The Kent Hospital Wound Recovery and Hyperbaric Medicine Center: a Brief Overview, 1998–2013
    CONTRIBUTION The Kent Hospital Wound Recovery and Hyperbaric Medicine Center: A Brief Overview, 1998–2013 LISA J. GOULD, MD, PhD; CATHERINE DECIANTIS, RN, CHRN; RONALD P. ZINNO, MD; GEORGE A. PERDRIZET, MD, PhD 13 17 EN ABSTRACT cannot devote the necessary time and effort required in the A brief description of the Wound Recovery and Hyperbaric management of these patients. Wound centers add value to Medicine Center, now in its second decade of service, the institutions and communities in which they serve. will inform the general medical community of this As the field has expanded, the science of chronic wound valuable asset. care has also grown. The increased utilization of hyperbaric Demand for wound care services is predicted to grow oxygen therapy (HBOT) is one example of this new growth. steadily over the next several decades. Kent Hospital’s vi- Approximately 10-15% of patients presenting to wound care sion for wound care is embodied in its thriving Wound centers will qualify for HBOT. Oxygen deficiency is a criti- Recovery and Hyperbaric Medicine Center. New cost- cal component of many wound types for which HBOT may effective wound healing therapies must be developed provide the cure or substantially boost other healing inter- and evidence-based practices established. New physi- ventions. Under the direction of Dr. Stephen Cummings, cians and support staff must be trained. Only through a Kent Hospital acquired three hyperbaric chambers in March blending of high quality clinical care with research and 2002, prompting a name change to the Kent Wound Recov- education will these objectives be achieved and future ery and Hyperbaric Medicine Center (KWRHMC) (Figure 1).
    [Show full text]
  • Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases
    BASIC RESEARCH www.jasn.org Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases † †‡ † Josef Ehling,* Janka Bábícková, Felix Gremse,* Barbara M. Klinkhammer, † | Sarah Baetke,* Ruth Knuechel, Fabian Kiessling,* Jürgen Floege,§ Twan Lammers,* ¶ and †‡ Peter Boor § *Institute for Experimental Molecular Imaging, Helmholtz Institute for Biomedical Engineering, Medical Faculty, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, Germany; †Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany; ‡Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia; §Department of Nephrology, Medical Faculty, RWTH Aachen University, Aachen, Germany; |Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; and ¶Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands ABSTRACT Progressive kidney diseases and renal fibrosis are associated with endothelial injury and capillary rarefaction. However, our understanding of these processes has been hampered by the lack of tools enabling the quantitative and noninvasive monitoring of vessel functionality. Here, we used micro-computed tomography (mCT) for anatomical and functional imaging of vascular alterations in three murine models with distinct mechanisms of progressive kidney injury: ischemia-reperfusion (I/R, days 1–56), unilateral ureteral obstruction (UUO, days 1–10), and Alport mice (6–8 weeks old). Contrast-enhanced in vivo mCT enabled robust, non- invasive, and longitudinal monitoring of vessel functionality and revealed a progressive decline of the renal relative blood volume in all models. This reduction ranged from 220% in early disease stages to 261% in late disease stages and preceded fibrosis. Upon Microfil perfusion, high-resolution ex vivo mCT allowed quanti- tative analyses of three-dimensional vascular networks in all three models.
    [Show full text]
  • Synchrotron Microangiography Studies of Angiogenesis in Mice with Microemulsions and Gold Nanoparticles
    Anal Bioanal Chem (2010) 397:2109–2116 DOI 10.1007/s00216-010-3775-8 ORIGINAL PAPER Synchrotron microangiography studies of angiogenesis in mice with microemulsions and gold nanoparticles Chia-Chi Chien & C. H. Wang & C. L. Wang & E. R. Li & K. H. Lee & Y. Hwu & Chien-Yi Lin & Shing-Jyh Chang & C. S. Yang & Cyril Petibois & G. Margaritondo Received: 7 February 2010 /Revised: 17 April 2010 /Accepted: 22 April 2010 /Published online: 6 June 2010 # Springer-Verlag 2010 Abstract We present an effective solution for the problem provides the best contrast and minimal distortion of the of contrast enhancement in phase-contrast microangiogra- circulation and vessel structure. Such emulsions are phy, with the specific objective of visualising small reasonably biocompatible and, with sizes of 0±0.8 µm, (<8 µm) vessels in tumor-related microangiogenesis. sufficient to diffuse to the smallest vessel and still provide Different hydrophilic and hydrophobic contrast agents were reasonable contrast. We also explored the use of Au explored in this context. We found that an emulsified nanoparticle colloids that could be used not only to enhance version of the hydrophobic contrast agents Lipiodol® contrast but also for interesting applications in nano- medicine. Both the Lipiodol microemulsions and Au nanoparticle colloids can be conjugated with medicines or C.-C. Chien : C. H. Wang : C. L. Wang : E. R. Li : K. H. Lee : Y. Hwu (*) cell specific labeling agents and their small size can allow Institute of Physics, Academia Sinica, the study of the diffusion of contrast agents through the Nankang, vessel leakage. This enables direct imaging of drug delivery Taipei 115, Taiwan, China which is important for cancer treatment.
    [Show full text]
  • How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics
    biomedicines Article Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics Fabien Bornert 1,2,3,†, François Clauss 1,2,3,†, Guoqiang Hua 1,2,†, Ysia Idoux-Gillet 1,2,†, Laetitia Keller 1,2,†, Gabriel Fernandez De Grado 1,2,3,†, Damien Offner 1,2,3 , Rana Smaida 1,2, Quentin Wagner 1,2, Florence Fioretti 1,2,3, Sabine Kuchler-Bopp 1,2 , Georg Schulz 4, Wolfgang Wenzel 5, Luca Gentile 1,2, Laurent Risser 6, Bert Müller 4 , Olivier Huck 1,2,3 and Nadia Benkirane-Jessel 1,2,3,* 1 INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine, CRBS, 1 Rue Eugène Boeckel, 67000 Strasbourg, France; [email protected] (F.B.); [email protected] (F.C.); [email protected] (G.H.); [email protected] (Y.I.-G.); [email protected] (L.K.); [email protected] (G.F.D.G.); [email protected] (D.O.); [email protected] (R.S.); [email protected] (Q.W.); fi[email protected] (F.F.); [email protected] (S.K.-B.); [email protected] (L.G.); [email protected] (O.H.) 2 Faculty of Dental Surgery, University of Strasbourg, University Hospital Strasbourg (HUS), 8 Rue de Sainte Elisabeth, 67000 Strasbourg, France 3 Department of Pediatric Dentistry, University Hospital Strasbourg (HUS), 1 Place de l’Hôpital, Citation: Bornert, F.; Clauss, F.; Hua, 67000 Strasbourg, France 4 G.; Idoux-Gillet, Y.; Keller, L.; Biomaterials Science Center, University of Basel, Gewerbestrasse 14, CH-4123 Allschwil, Switzerland; Fernandez De Grado, G.; Offner, D.; [email protected] (G.S.); [email protected] (B.M.) 5 Smaida, R.; Wagner, Q.; Fioretti, F.; Institute of Nanotechnology, Karlsruhe Institute of Technology, Campus North, Building 640, DE-76131 Karlsruhe, Germany; [email protected] et al.
    [Show full text]
  • Endothelial TLR4 Activation Impairs Intestinal Microcirculatory Perfusion in Necrotizing Enterocolitis Via Enos–NO–Nitrite Signaling
    Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling Ibrahim Yazjia,b, Chhinder P. Sodhia,b, Elizabeth K. Leea,b, Misty Goodc,d, Charlotte E. Egana,b, Amin Afrazia,b, Matthew D. Neala,b, Hongpeng Jiaa,b, Joyce Lina,b, Congrong Maa,b, Maria F. Brancaa,b, Thomas Prindlea,b, Ward M. Richardsonb, John Ozoleke,f, Timothy R. Billiarb, David G. Biniong, Mark T. Gladwinh,i, and David J. Hackama,b,1 Divisions of aPediatric Surgery, cNewborn Medicine, and ePathology, Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224; and Departments of bSurgery, dPediatrics, and fPathology and Divisions of gGastroenterology and hPulmonary, Allergy, and Critical Care Medicine, and iVascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Edited by Ruslan Medzhitov, Yale University School of Medicine, New Haven, CT, and approved April 12, 2013 (received for review November 16, 2012) Necrotizing enterocolitis (NEC) is a devastating disease of pre- (NO), which is generated through the activity of endothelial NO mature infants characterized by severe intestinal necrosis and for synthase (eNOS) (6). Recent studies have shown that NO can which breast milk represents the most effective protective strat- also be generated through conversion from sodium nitrite egy. Previous studies have revealed a critical role for the lipopoly- within the diet through the activity of commensal microbes (7). saccharide receptor toll-like receptor 4 (TLR4) in NEC development Given that TLR4 is expressed on endothelial cells (8), we now through its induction of mucosal injury, yet the reasons for which hypothesize that TLR4 signaling within the endothelium plays intestinal ischemia in NEC occurs in the first place remain unknown.
    [Show full text]