Neuroanatomical Foundations of Cognition 39 Empirical Engagement
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Challenges and Techniques for Presurgical Brain Mapping with Functional MRI
Challenges and techniques for presurgical brain mapping with functional MRI The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Silva, Michael A., Alfred P. See, Walid I. Essayed, Alexandra J. Golby, and Yanmei Tie. 2017. “Challenges and techniques for presurgical brain mapping with functional MRI.” NeuroImage : Clinical 17 (1): 794-803. doi:10.1016/j.nicl.2017.12.008. http://dx.doi.org/10.1016/ j.nicl.2017.12.008. Published Version doi:10.1016/j.nicl.2017.12.008 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651769 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA NeuroImage: Clinical 17 (2018) 794–803 Contents lists available at ScienceDirect NeuroImage: Clinical journal homepage: www.elsevier.com/locate/ynicl Challenges and techniques for presurgical brain mapping with functional T MRI ⁎ Michael A. Silvaa,b, Alfred P. Seea,b, Walid I. Essayeda,b, Alexandra J. Golbya,b,c, Yanmei Tiea,b, a Harvard Medical School, Boston, MA, USA b Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA c Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA ABSTRACT Functional magnetic resonance imaging (fMRI) is increasingly used for preoperative counseling and planning, and intraoperative guidance for tumor resection in the eloquent cortex. Although there have been improvements in image resolution and artifact correction, there are still limitations of this modality. -
Functional Brain Mapping and Neuromodulation Enhanced
In non-clinical populations, brain mapping Neurofeedback and tDCS are also being used to enhance performance and cognitive functions such as reaction time and decision speed in individuals who are functioning in highly-competitive environments. For additional information on these and other recently developed diagnostic tests, treatment interventions and peak performance training, please call The NeuroCognitive Institute and schedule a consultation. One of Many Scientific References on Functional Brain Mapping and Neuromodulation Functional Brain Mapping and the Endeavor to Understand the Working Brain: Signorelli and Chirchiglia (2013). Mind Over Chatter: Plastic up-regulation of the fMRI salience network directly after EEG Neurofeedback. Neuroimage, 65, 324-335 About The NeuroCognitive Institute Established in 1994, The NeuroCognitive Institute is committed to its scientist-practitioner model which requires its clinicians to remain ac- tively involved in neuroscience research. Over the past two decades, NCI has become one of the premiere centers in New Jersey for the diag- nosis and treatment of cognitive and related neurobehavioral and neuro- psychiatric disorders. The team consists of clinical and cognitive neuro- psychologists, cognitive and behavioral neurologists, clinical psycholo- gists, neuropsychiatrists, cognitive and speech and language therapists, as well as, behaviorists, psychotherapists and neuromodulation clini- cians. Locations Morris County: 111 Howard Blvd., Suites 204-205, Mt. Arlington, NJ 07856 Somerset County: Medical Plaza Building., 1 Robertson Drive, Suite 22, Bedminster, NJ 07921 Essex County: Barnabas Health Ambulatory Care Center, Suite 270, Functional Brain Mapping and 200 South Orange Avenue, Livingston, NJ 07039 Neuromodulation Enhanced Contact Us Phone: 973.601.0100 Cognitive Rehabilitation Fax: 973.440.1656 Email: [email protected] Web: neuroci.com We can use functional brain mapping results to identify treatment targets. -
Tor Wager Diana L
Tor Wager Diana L. Taylor Distinguished Professor of Psychological and Brain Sciences Dartmouth College Email: [email protected] https://wagerlab.colorado.edu Last Updated: July, 2019 Executive summary ● Appointments: Faculty since 2004, starting as Assistant Professor at Columbia University. Associate Professor in 2009, moved to University of Colorado, Boulder in 2010; Professor since 2014. 2019-Present: Diana L. Taylor Distinguished Professor of Psychological and Brain Sciences at Dartmouth College. ● Publications: 240 publications with >50,000 total citations (Google Scholar), 11 papers cited over 1000 times. H-index = 79. Journals include Science, Nature, New England Journal of Medicine, Nature Neuroscience, Neuron, Nature Methods, PNAS, Psychological Science, PLoS Biology, Trends in Cognitive Sciences, Nature Reviews Neuroscience, Nature Reviews Neurology, Nature Medicine, Journal of Neuroscience. ● Funding: Currently principal investigator on 3 NIH R01s, and co-investigator on other collaborative grants. Past funding sources include NIH, NSF, Army Research Institute, Templeton Foundation, DoD. P.I. on 4 R01s, 1 R21, 1 RC1, 1 NSF. ● Awards: Awards include NSF Graduate Fellowship, MacLean Award from American Psychosomatic Society, Colorado Faculty Research Award, “Rising Star” from American Psychological Society, Cognitive Neuroscience Society Young Investigator Award, Web of Science “Highly Cited Researcher”, Fellow of American Psychological Society. Two patents on research products. ● Outreach: >300 invited talks at universities/international conferences since 2005. Invited talks in Psychology, Neuroscience, Cognitive Science, Psychiatry, Neurology, Anesthesiology, Radiology, Medical Anthropology, Marketing, and others. Media outreach: Featured in New York Times, The Economist, NPR (Science Friday and Radiolab), CBS Evening News, PBS special on healing, BBC, BBC Horizons, Fox News, 60 Minutes, others. -
Cognitive & Affective Neuroscience
Cognitive & Affective Neuroscience: From Circuitry to Network and Behavior Monday, Jun 18: 8:00 AM - 9:15 AM 1835 Symposium Monday - Symposia AM Using a multi-disciplinary approach integrating cognitive, EEG/ERP and fMRI techniques and advanced analytic methods, the four speakers in this symposium investigate neurocognitive processes underlying nuanced cognitive and affective functions in humans. the neural basis of changing social norms through persuasion using carefully designed behavioral paradigms and functional MRI technique; Yuejia Luo will describe how high temporal resolution EEG/ERPs predict dynamical profiles of distinct neurocognitive stages involved in emotional negativity bias and its reciprocal interactions with executive functions such as working memory; Yongjun Yu conducts innovative behavioral experiments in conjunction with fMRI and computational modeling approaches to dissociate interactive neural signals involved in affective decision making; and Shaozheng Qin applies fMRI with simultaneous recording skin conductance and advanced analytic approaches (i.e., MVPA, network dynamics) to determine neural representational patterns and subjects can modulate resting state networks, and also uses graph theory network activity levels to delineate dynamic changes in large-scale brain network interactions involved in complex interplay of attention, emotion, memory and executive systems. These talks will provide perspectives on new ways to study brain circuitry and networks underlying interactions between affective and cognitive functions and how to best link the insights from behavioral experiments and neuroimaging studies. Objective Having accomplished this symposium or workshop, participants will be able to: 1. Learn about the latest progress of innovative research in the field of cognitive and affective neuroscience; 2. Learn applications of multimodal brain imaging techniques (i.e., EEG/ERP, fMRI) into understanding human cognitive and affective functions in different populations. -
Ted K. Turesky, Ph.D
Ted K. Turesky, Ph.D. [email protected] | 207-807-0962 | teddyturesky.github.io | github.com/teddyturesky EDUCATION 2021 – Present Post-Doctoral Fellowship, Developmental Cognitive Neuroscience Harvard Graduate School of Education Mentor: Nadine Gaab, Ph.D. Co-Mentor: Charles Nelson, PhD 2017 – 2020 Post-Doctoral Fellowship, Developmental Cognitive Neuroscience Boston Children’s Hospital/Harvard Medical School Mentor: Nadine Gaab, Ph.D. Co-Mentor: Charles Nelson, PhD 2012 – 2017 Ph.D., Interdisciplinary Program in Neuroscience (IPN) Georgetown University, Washington, DC Mentor: Guinevere Eden, D.Phil. 2004 – 2008 B.A., Physics Colorado College, Colorado Springs, CO HONORS AND FELLOWSHIPS 2021 Harvard Brain Initiative Transitions Award Harvard University 2019 Harvard Brain Initiative Travel Award Harvard University 2017 Karen Gale Exceptional Ph.D. Student Award in Science Georgetown University Graduate School of Arts and Sciences 2017 Medical Center Graduate Student Organization Travel Grant Georgetown University Medical Center 2015 – 2017 Neural Injury and Plasticity Pre-Doctoral Training Fellowship National Institute of Neurological Disorders and Stroke, NIH Thesis stipend, tuition, and research funds (T32, PI: Kathleen Maguire-Zeiss) 2012 – 2013 Interdisciplinary Program in Neuroscience Pre-Doc Training Fellowship National Institute of Neurological Disorders and Stroke, NIH Pre-thesis stipend, and tuition (T32, PI: Karen Gale) 2008 Transitions Fellowship for Study of Healthcare in Rural Malawi Colorado College 2007 , 2008 Dean’s List Colorado College RESEARCH EXPERIENCE 2017 – Present Post-Doctoral Fellow, Developmental Cognitive Neuroscience Harvard Graduate School of Education, Cambridge, MA Boston Children’s Hospital, Boston, MA Project: How poverty affects brain development using s/f/dMRI 1 Ted K. Turesky 2012 – 2017 Ph.D. -
Cajal's Law of Dynamic Polarization: Mechanism and Design
philosophies Article Cajal’s Law of Dynamic Polarization: Mechanism and Design Sergio Daniel Barberis ID Facultad de Filosofía y Letras, Instituto de Filosofía “Dr. Alejandro Korn”, Universidad de Buenos Aires, Buenos Aires, PO 1406, Argentina; sbarberis@filo.uba.ar Received: 8 February 2018; Accepted: 11 April 2018; Published: 16 April 2018 Abstract: Santiago Ramón y Cajal, the primary architect of the neuron doctrine and the law of dynamic polarization, is considered to be the founder of modern neuroscience. At the same time, many philosophers, historians, and neuroscientists agree that modern neuroscience embodies a mechanistic perspective on the explanation of the nervous system. In this paper, I review the extant mechanistic interpretation of Cajal’s contribution to modern neuroscience. Then, I argue that the extant mechanistic interpretation fails to capture the explanatory import of Cajal’s law of dynamic polarization. My claim is that the definitive formulation of Cajal’s law of dynamic polarization, despite its mechanistic inaccuracies, embodies a non-mechanistic pattern of reasoning (i.e., design explanation) that is an integral component of modern neuroscience. Keywords: Cajal; law of dynamic polarization; mechanism; utility; design 1. Introduction The Spanish microanatomist and Nobel laureate Santiago Ramón y Cajal (1852–1934), the primary architect of the neuron doctrine and the law of dynamic polarization, is considered to be the founder of modern neuroscience [1,2]. According to the neuron doctrine, the nerve cell is the anatomical, physiological, and developmental unit of the nervous system [3,4]. To a first approximation, the law of dynamic polarization states that nerve impulses are exactly polarized in the neuron; in functional terms, the dendrites and the cell body work as a reception device, the axon works as a conduction device, and the terminal arborizations of the axon work as an application device. -
The Churchlands' Neuron Doctrine: Both Cognitive and Reductionist
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/231998559 The Churchlands' neuron doctrine: Both cognitive and reductionist Article in Behavioral and Brain Sciences · October 1999 DOI: 10.1017/S0140525X99462193 CITATIONS READS 2 20 1 author: John Sutton Macquarie University 139 PUBLICATIONS 1,356 CITATIONS SEE PROFILE All content following this page was uploaded by John Sutton on 06 August 2014. The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately. The Churchlands’ neuron doctrine: both cognitive and reductionist John Sutton Macquarie University, Sydney, NSW 2109, Australia Behavioral and Brain Sciences, 22 (1999), 850-1. [email protected] http://johnsutton.net/ Commentary on Gold & Stoljar, ‘A Neuron Doctrine in the Philosophy of Neuroscience’, Behavioral and Brain Sciences, 22 (1999), 809-869: full paper and commentaries online at: http://www.stanford.edu/~paulsko/papers/GSND.pdf Abstract: According to Gold and Stoljar, one cannot both consistently be reductionist about psychoneural relations and invoke concepts developed in the psychological sciences. I deny the utility of their distinction between biological and cognitive neuroscience, suggesting that they construe biological neuroscience too rigidly and cognitive neuroscience too liberally. Then I reject their characterization of reductionism: reductions need not go down past neurobiology straight to physics, and cases of partial, local reduction are not neatly distinguishable from cases of mere implementation. Modifying the argument from unification-as-reduction, I defend a position weaker than the radical, but stronger than the trivial neuron doctrine. -
BRAIN MAPPING COURSE April 26–27, 2018, New Orleans an AANS Masters Course Held in Cooperation with the NREF
Hosted Immediately Prior to the 2018 AANS Annual Scientific Meeting SECOND INTERNATIONAL BRAIN MAPPING COURSE April 26–27, 2018, New Orleans An AANS Masters Course Held in Cooperation with the NREF Course Directors Mitchel S. Berger, MD, FAANS, University of California San Francisco (UCSF) Richard W. Byrne, MD, FAANS, Rush University Medical Center Hugues Duffau, MD, Hôpital Gui de Chauliac Honored Guest: Gregory Hickok, PhD, University of California, Irvine Invited Speakers Lorenzo Bello, MD, PhD Juan Martino, MD Marco Catani, MD, PhD Guy M. McKhann II, MD, FAANS Edward F. Chang, MD, FAANS Jeffrey G. Ojemann, MD, FAANS Nina Dronkers, PhD Zvi Ram, MD, IFAANS Alexandra J. Golby, MD, FAANS Guilherme C. Ribas, MD Gregory Hickok, PhD James T. Rutka, MD, PhD, FAANS Toshihiro Kumabe, MD, PhD George Samandouras, MD Chanhung Lee, MD, PhD Phiroz Erach Tarapore, MD, FAANS Emmanuel Mandonnet, MD, PhD Jinsong Wu, MD, PhD Course Overview A distinguished international faculty will present Session 3: Intraoperative and Extraoperative advances, advantages and practical issues in Mapping contemporary preoperative and intraoperative Session 4: Lunch Session: Controversies in brain mapping applications in brain tumor Cortical Mapping (Expert panel discussion, and functional neurosurgery. Content will be case presentations) presented in five sessions over two days. Session 5: Special Topics in Stimulation, Session 1: Functional Anatomy, Physiology and Research Techniques, the Future of Brain Mapping with Imaging Brain Mapping Session 2: Dinner Session: Special Lecture — Dr. Gregory Hickok Learning Objectives Upon completion of this CME activity, learners will be able to: Describe both the anatomic and functional List the potential pitfalls in sensitivity and anatomy of eloquent cortex. -
Social Cognitive Neuroscience: a Review of Core Systems
C HAPTER 2 2 SOCIAL COGNITIVE NEUROSCIENCE: A REVIEW OF CORE SYSTEMS Bruce P. Doré, Noam Zerubavel, and Kevin N. Ochsner Descartes famously argued that the mind is both SOCIAL COGNITIVE NEUROSCIENCE everlasting and indivisible (Descartes, 1988). If he APPROACH was right about the first part, he is probably pretty In the past decade, the field of social cognitive neuro- impressed with the advance of human knowledge science (SCN) has attempted to fill this gap, integrat- on the second. Although Descartes’ position on ing the theories and methods of two parent the indivisibility of the mind has been echoed at disciplines: social psychology and cognitive neurosci- times in the history of psychology and neurosci- ence. Stressing the interdependence of brain, mind, ence (Flourens & Meigs, 1846; Lashley, 1929; and social context, SCN seeks to explain psychological Uttal, 2003), the modern field has made steady phenomena at three levels of analysis: the neural level progress in demonstrating that subjective mental of brain systems, the cognitive level of information life can be understood as the product of distinct processing mechanisms, and the social level of the functional systems. Today, largely because of the experiences and actions of social agents (Ochsner & success of cognitive neuroscience models, Lieberman, 2001). In contrast to scientific approaches researchers understand that people’s intellectual that grant near exclusive focus to a single level of anal- faculties emerge from the operation of core ysis (e.g., behaviorism, artificial -
Richard Scheller and Thomas Südhof Receive the 2013 Albert Lasker Basic Medical Research Award
Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award Jillian H. Hurst J Clin Invest. 2013;123(10):4095-4101. https://doi.org/10.1172/JCI72681. News Neural communication underlies all brain activity. It governs our thoughts, feelings, sensations, and actions. But knowing the importance of neural communication does not answer a central question of neuroscience: how do individual neurons communicate? We know that communication between two neurons occurs at specialized cell junctions called synapses, at which two communicating neurons are separated by the synaptic cleft. The presynaptic neuron releases chemicals, known as neurotransmitters, into the synaptic cleft in which neurotransmitters bind to receptors on the surface of the postsynaptic neuron. Neurotransmitter release occurs in response to an action potential within the sending neuron that induces depolarization of the nerve terminal and causes an influx of calcium. Calcium influx triggers the release of neurotransmitters through a specialized form of exocytosis in which neurotransmitter-filled vesicles fuse with the plasma membrane of the presynaptic nerve terminal in a region known as the active zone, spilling neurotransmitter into the synaptic cleft. By the 1950s, it was clear that brain function depended on chemical neurotransmission; however, the molecular activities that governed neurotransmitter release were virtually unknown until the early 1990s. This year, the Lasker Foundation honors Richard Scheller (Genentech) and Thomas Südhof (Stanford University School of Medicine) for their “discoveries concerning the molecular machinery and regulatory mechanisms that underlie the rapid release of neurotransmitters.” Over the course of two decades, Scheller […] Find the latest version: https://jci.me/72681/pdf News Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award Neural communication underlies all Setting the stage um-driven action potentials elicited neu- brain activity. -
Eric D. Wilkey, Phd
Wilkey CV 1 Eric D. Wilkey, PhD Contact Information Department of Psychology Louisiana State University Baton Rouge, LA 70803 Email: [email protected] Website: ericdwilkey.com EDUCATION Ph.D. 2013 – 2018 Neuroscience Vanderbilt University, Nashville TN M. Ed. 2010 – 2011 Mind, Brain and Education Harvard University, Cambridge, MA B.A. 2003 – 2007 Philosophy, minors in Classical Greek and Studio Art Belmont University, Nashville, TN APPOINTMENTS Assistant Professor starting Jan 2022 Department of Psychology Louisiana State University Assistant Professor starting Jan 2022 Center for Computation & Technology Louisiana State University Postdoc 2018 – present Brain and Mind Institute Western University, London, ON, Canada Advisor: Dr. Daniel Ansari Research Analyst 2011 – 2013 Vanderbilt University, Peabody Research Institute • Large-scale meta-analysis of predictors of school success • City-wide Kindergarten reading intervention assessment Wilkey CV 2 FELLOWSHIPS & AWARDS 2021 Western University Postdoctoral Scholar of the Year 2019–2021 Banting Postdoctoral Fellowship (only 70 awarded yearly across Canada), awarded by The Natural Sciences and Engineering Research Council of Canada (NSERC) $140,000 CAD ($70K per year CAD). 2019–2021 BrainsCAN Tier I Postdoctoral Fellowship Award Top-Up, University of Western Ontario, $20,000 CAD ($10K per year CAD). 2018 Travel grant award by BrainsCAN to attend a workshop on Open Science at University College Cork, Ireland (October 2018) 2017–2018 Hardy Culver Wilcoxon Award, presented by the Peabody College Department of Psychology & Human Development (Vanderbilt University) to the graduate student with the most distinguished doctoral dissertation in any area of Psychological Inquiry. 2017 Competitive Research-Achievement Fellowship from Vanderbilt Department of Psychology and Human Development. Award provides stipend for one semester to pursue research aims that build on a previous first-author publication. -
From the Neuron Doctrine to Neural Networks
LINK TO ORIGINAL ARTICLE LINK TO INITIAL CORRESPONDENCE other hand, one of my mentors, David Tank, argued that for a true understanding of a On testing neural network models neural circuit we should be able to actu- ally build it, which is a stricter definition Rafael Yuste of a successful theory (D. Tank, personal communication) Finally, as mentioned in In my recent Timeline article, I described existing neural network models have enough the Timeline article, one will also need to the emergence of neural network models predictive value to be considered valid or connect neural network models to theories as an important paradigm in neuroscience useful for explaining brain circuits.” (REF. 1)). and facts at the structural and biophysical research (From the neuron doctrine to neu- There are many exciting areas of progress levels of neural circuits and to those in cog- ral networks. Nat. Rev. Neurosci. 16, 487–497 in current neuroscience detailing phenom- nitive sciences as well, for proper ‘scientific (2015))1. In his correspondence (Neural enology that is consistent with some neural knowledge’ to occur in the Kantian sense. networks in the future of neuroscience network models, some of which I tried to research. Nat. Rev. Neurosci. http://dx.doi. summarize and illustrate, but at the same Rafael Yuste is at the Neurotechnology Center and org/10.1038/nrn4042 (2015))2, Rubinov time we are still far from a rigorous demon- Kavli Institute of Brain Sciences, Departments of provides some thoughtful comments about stration of any neural network model with Biological Sciences and Neuroscience, Columbia University, New York, New York 10027, USA.