BTRC monoclonal antibody, clone Alias: BETA-TRCP, FBW1A, FBXW1, FBXW1A, 3D5E6 FWD1, MGC4643, bTrCP, bTrCP1, betaTrCP

Gene Summary: This gene encodes a member of the Catalog Number: MAB17560 F-box family which is characterized by an Regulation Status: For research use only (RUO) approximately 40 amino acid motif, the F-box. The F-box constitute one of the four subunits of Product Description: Mouse monoclonal antibody protein ligase complex called SCFs (SKP1-cullin-F-box), raised against recombinant human BTRC. which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 Clone Name: 3D5E6 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing Immunogen: Recombinant protein corresponding to either different protein-protein interaction modules or no amino acid 24-151 of human BTRC from E. coli. recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this Host: Mouse protein contains multiple WD-40 repeats. This protein is homologous to bTrCP1, yeast Met30, Theoretical MW (kDa): 68.9 Neurospora Scon2 and Slimb proteins. It Reactivity: Human interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with Applications: ELISA, IHC-P, WB-Ce, WB-Tr phosphorylated IkappaBalpha and beta- (See our web site product page for detailed applications destruction motifs, probably functioning in multiple information) transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. Protocols: See our web site at [provided by RefSeq] http://www.abnova.com/support/protocols.asp or product page for detailed protocols

Form: Liquid

Isotype: IgG1

Recommend Usage: ELISA (1:10000) Western Blot (1:500-1:2000) Immunocytochemistry Flow Cytometry Immunohistochemistry (1:200-1:1000) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS (0.05% sodium azide).

Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 8945

Gene Symbol: BTRC

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