BTRC Monoclonal Antibody, Clone 3D5E6

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BTRC monoclonal antibody, clone Gene Alias: BETA-TRCP, FBW1A, FBXW1, FBXW1A, 3D5E6 FWD1, MGC4643, bTrCP, bTrCP1, betaTrCP Gene Summary: This gene encodes a member of the Catalog Number: MAB17560 F-box protein family which is characterized by an Regulation Status: For research use only (RUO) approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin Product Description: Mouse monoclonal antibody protein ligase complex called SCFs (SKP1-cullin-F-box), raised against recombinant human BTRC. which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 Clone Name: 3D5E6 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing Immunogen: Recombinant protein corresponding to either different protein-protein interaction modules or no amino acid 24-151 of human BTRC from E. coli. recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this Host: Mouse protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Theoretical MW (kDa): 68.9 Neurospora Scon2 and Drosophila Slimb proteins. It Reactivity: Human interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with Applications: ELISA, IHC-P, WB-Ce, WB-Tr phosphorylated IkappaBalpha and beta-catenin (See our web site product page for detailed applications destruction motifs, probably functioning in multiple information) transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. Protocols: See our web site at [provided by RefSeq] http://www.abnova.com/support/protocols.asp or product page for detailed protocols Form: Liquid Isotype: IgG1 Recommend Usage: ELISA (1:10000) Western Blot (1:500-1:2000) Immunocytochemistry Flow Cytometry Immunohistochemistry (1:200-1:1000) The optimal working dilution should be determined by the end user. Storage Buffer: In PBS (0.05% sodium azide). Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 8945 Gene Symbol: BTRC Page 1/1 Powered by TCPDF (www.tcpdf.org).

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