The Following Acronyms and Terms Have Been Compiled Through Input from the ARVO Membership and Are Presented Here for Your Reference
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Visual Acuity Assessment
VISUAL ACUITY ASSESSMENT J. R. WEATHERILL Bradford Tests of visual function in cataract patients are performed recognised that patients with macular dysfunction have in order to answer two questions: (I) To what extent is the difficulty in reading out of proportion to their Snellen cataract responsible for the patient's symptoms? (2) Will acuity. This difficultyis probably due to parafoveal scoto removal of the cataract improve the patient's sight? To mas which prevent the whole word being seen at the same answer the firstquestion the optical qualities of the eye are time. If a patient reports that the main problem is with assessed, and to answer the second tests are employed reading, it is helpful to observe whether the patient holds which assess retinal and neural function and which are the page steadily or keeps moving it to avoid scotomas. relatively unaffected by the optical degradation caused by With current reading tests patients with poor macular opacities in the media. At Bradford we employ the tests function can read small print for brief periods, particularly listed in Table I. if they are used to reading and recognise the overall shape of the words. A Logmar equivalent for near vision com Snellen Acuity prising random words of equal length and composed of Although the Snellen acuity test measures the function of letters without either ascenders or descenders, read under only the central 1_20 in monochrome at 100% contrast, it controlled conditions of illumination and at a standard dis is nonetheless the 'gold standard' by which ophthal tance, would provide a more accurate measure of macular mologists judge and are judged. -
History of Refractive Surgery
History of Refractive Surgery Refractive surgery corrects common vision problems by reshaping the cornea, the eye’s outermost layer, to bend light rays to focus on the retina, reducing an individual’s dependence on eye glasses or contact lenses.1 LASIK, or laser-assisted in situ keratomileusis, is the most commonly performed refractive surgery to treat myopia, hyperopia and astigmatism.1 The first refractive surgeries were said to be the removal of cataracts – the clouding of the lens in the eye – in ancient Greece.2 1850s The first lensectomy is performed to remove the lens 1996 Clinical trials for LASIK begin and are approved by the of the eye to correct myopia.2 Food & Drug Administration (FDA).3 Late 19th 2 Abott Medical Optics receives FDA approval for the first Century The first surgery to correct astigmatism takes place. 2001 femtosecond laser, the IntraLase® FS Laser.3 The laser is used to create a circular, hinged flap in the cornea, which allows the surgeon access to the tissue affecting the eye’s 1978 Radial Keratotomy is introduced by Svyatoslov Fyodorov shape.1 in the U.S. The procedure involves making a number of incisions in the cornea to change its shape and 2002 The STAR S4 IR® Laser is introduced. The X generation is correct refractive errors, such as myopia, hyperopia used in LASIK procedures today.4 and astigmatism.2,3 1970s Samuel Blum, Rangaswamy Srinivasan and James J. Wynne 2003 The FDA approves the use of wavefront technology,3 invent the excimer laser at the IBM Thomas J. Watson which creates a 3-D map of the eye to measure 1980s Research Center in Yorktown, New York. -
GUIDE for the Evaluation of VISUAL Impairment
International Society for Low vision Research and Rehabilitation GUIDE for the Evaluation of VISUAL Impairment Published through the Pacific Vision Foundation, San Francisco for presentation at the International Low Vision Conference VISION-99. TABLE of CONTENTS INTRODUCTION 1 PART 1 – OVERVIEW 3 Aspects of Vision Loss 3 Visual Functions 4 Functional Vision 4 Use of Scales 5 Ability Profiles 5 PART 2 – ASSESSMENT OF VISUAL FUNCTIONS 6 Visual Acuity Assessment 6 In the Normal and Near-normal range 6 In the Low Vision range 8 Reading Acuity vs. Letter Chart Acuity 10 Visual Field Assessment 11 Monocular vs. Binocular Fields 12 PART 3 – ESTIMATING FUNCTIONAL VISION 13 A General Ability Scale 13 Visual Acuity Scores, Visual Field Scores 15 Calculation Rules 18 Functional Vision Score, Adjustments 20 Examples 22 PART 4 – DIRECT ASSESSMENT OF FUNCTIONAL VISION 24 Vision-related Activities 24 Creating an Activity Profile 25 Participation 27 PART 5 – DISCUSSION AND BACKGROUND 28 Comparison to AMA scales 28 Statistical Use of the Visual Acuity Score 30 Comparison to ICIDH-2 31 Bibliography 31 © Copyright 1999 by August Colenbrander, M.D. All rights reserved. GUIDE for the Evaluation of VISUAL Impairment Summer 1999 INTRODUCTION OBJECTIVE Measurement Guidelines for Collaborative Studies of the National Eye Institute (NEI), This GUIDE presents a coordinated system for the Bethesda, MD evaluation of the functional aspects of vision. It has been prepared on behalf of the International WORK GROUP Society for Low Vision Research and Rehabilitation (ISLRR) for presentation at The GUIDE was approved by a Work Group VISION-99, the fifth International Low Vision including the following members: conference. -
Perioperative Assessment for Refractive Cataract Surgery
642 REVIEW/UPDATE Perioperative assessment for refractive cataract surgery Kendall Donaldson, MD, MS, Luis Fernandez-Vega-Cueto, MD, PhD, Richard Davidson, MD, Deepinder Dhaliwal, MD, Rex Hamilton, MD, Mitchell Jackson, MD, Larry Patterson, MD, Karl Stonecipher, MD, for the ASCRS Refractive–Cataract Surgery Subcommittee As cataract surgery has evolved into lens-based refractive surgery, decisions regarding the power of the IOL to be implanted during cata- expectations for refractive outcomes continue to increase. During ract surgery. However, with all the available technology, it can be diffi- the past decade, advancements in technology have provided new cult to decipher which of the many technologies is necessary or best ways to measure the cornea in preparation for cataract surgery. for patients and for practices. This article reviews currently available The increasing ability to accurately estimate corneal power allows options for topography, tomography, keratometry, and biometry in determination of the most precise intraocular lens (IOL) for each pa- preparation for cataract surgery. In addition, intraoperative aberrom- tient. New equipment measures the anterior and posterior corneal etry and integrated cataract suites are reviewed. surfaces to most accurately estimate corneal power and corneal ab- errations. These measurements help surgeons make the best J Cataract Refract Surg 2018; 44:642–653 Q 2018 ASCRS and ESCRS ver the past 2 decades, we have experienced an only the anterior corneal surface with the use of topo- evolution in cataract surgery from simply the graphic devices; however with discovery of the impact of O removal of the cloudy lens to a refractive proced- posterior corneal astigmatism, we can now achieve higher ure that provides patients with increasingly higher levels degrees of accuracy by taking into account the effect of the of spectacle independence. -
Binocular Vision Disorders Prescribing Guidelines
Prescribing for Preverbal Children Valerie M. Kattouf O.D. FAAO, FCOVD Illinois College of Optometry Associate Professor Prescribing for Preverbal Children Issues to consider: Age Visual Function Refractive Error Norms Amblyogenic Risk Factors Birth History Family History Developmental History Emmetropization A process presumed to be operative in producing a greater frequency of occurrence of emmetropia than would be expected in terms of chance distribution, as may be explained by postulating that a mechanism coordinates the formation and the development of the various components of the human eye which contribute to the total refractive power Emmetropization Passive process = nature and genetics 60% chance of myopia if 2 parents myopic (Ciuffrieda) Active process = mediated by blur and visual system compensates for blur Refractive Error Norms Highest rate of emmetropization – 1st 12-17 months Hyperopia Average refractive error in infants = +2 D > 1.50 diopters hyperopia at 5 years old – often remain hyperopic Refractive Error Norms Myopia 25% of infants are myopic Myopic Newborns (Scharf) @ 7 years 54% still myopic @ 7 years 46% emmetropic @ 7 years no hyperopia Refractive Error Norms Astigmatism Against the rule astigmatism more prevalent switches to with-the-rule with development At 3 1/2 years old astigmatism is at adult levels INFANT REFRACTION NORMS AGE SPHERE CYL 0-1mo -0.90+/-3.17 -2.02+/-1.43 2-3mo -0.47+/-2.28 -2.02+/-1.17 4-6mo -0.00+/-1.31 -2.20+/-1.15 6-9mo +0.50+/-0.99 -2.20+/-1.15 9-12mo +0.60+/-1.30 -1.64+/-0.62 -
2018 Department of Ophthalmology Chair Report
SAVE THE▼ DATE Department of 200 Ophthalmology Years www.NYEE.edu Anniversary SPECIALTY REPORT | FALL 2018 www.NYEE.edu Celebration Join us for 200 Years and Counting: Bicentennial Cocktail Celebration October 15, 2020 Research Breakthrough: The Plaza 768 5th Avenue Gene Transfer New York, NY Therapy Restores 200 Years and Counting: Ophthalmology Vision in Mice Symposium October 16, 2020 Stay tuned for details on tickets and registration information. Cover image: Slice of a central retina section showing all layers (ONL, INL, GCL). Red indicates rod photoreceptors, located in outer nuclear layer (ONL). Green indicates Müller glial cells, whose cell bodies are located in inner nuclear layer (INL), and their branches across all three layers. Dark blue indicates the nucleus of all cells in three layers (GCL). Icahn School of Medicine at Medical Directors Neuro-Ophthalmology Uveitis and Ocular Immunology Mount Sinai Departmental Mark Kupersmith, MD Douglas Jabs, MD, MBA Avnish Deobhakta, MD Leadership System Chief, System Chief, Uveitis and Ocular Medical Director, NYEE - Neuro-Ophthalmology, Immunology, MSHS James C. Tsai, MD, MBA East 85th Street MSHS President, NYEE Stephanie Llop, MD System Chair, Department of Robin N. Ginsburg, MD 3 Message From the System Chair of the DepartmentValerie Elmalem, of Ophthalmology MD Sophia Saleem, MD Ophthalmology, MSHS Medical Director, NYEE- Joel Mindel, MD East 102nd Street Louis4 R. Pasquale,Breaking MD New Ground in Gene Transfer Therapy to Restore Vision Affiliated Leadership Ocular Oncology Site Chair, Department of Gennady Landa, MD Paul Finger, MD Ebby Elahi, MD, MBA Ophthalmology, MSH and MSQ Medical Director, NYEE- 6 This i-Doctor Is Transforming the Field of Ophthalmology President, NYEE/MSH System Vice Chair, Translational Williamsburg and Tribeca Ophthalmic Pathology Ophthalmology Alumni Ophthalmology Research, MSHS Jodi Sassoon, MD Society Kira Manusis, MD Inside Feature Site Chair, Pathology, NYEE Medical Director, NYEE- Paul A. -
Ophthalmological Findings in Children and Adolescents with Silver Russell
Ophthalmological findings in children and adolescents with Silver Russell Syndrome Marita Andersson Gronlund, Jovanna Dahlgren, Eva Aring, Maria Kraemer, Ann Hellstrom To cite this version: Marita Andersson Gronlund, Jovanna Dahlgren, Eva Aring, Maria Kraemer, Ann Hellstrom. Oph- thalmological findings in children and adolescents with Silver Russell Syndrome. British Journal of Ophthalmology, BMJ Publishing Group, 2010, 95 (5), pp.637. 10.1136/bjo.2010.184457. hal- 00588358 HAL Id: hal-00588358 https://hal.archives-ouvertes.fr/hal-00588358 Submitted on 23 Apr 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Ophthalmological findings in children and adolescents with Silver Russell Syndrome M Andersson Grönlund, MD, PhD1, J Dahlgren, MD, PhD2, E Aring, CO, PhD1, M Kraemer, MD1, A Hellström, MD, PhD1 1Institute of Neuroscience and Physiology/Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. 2Institute for the Health of Women and Children, Gothenburg Paediatric Growth Research Centre (GP-GRC), The Sahlgrenska -
The Title of the Dissertation
UNIVERSITY OF CALIFORNIA SAN DIEGO Novel network-based integrated analyses of multi-omics data reveal new insights into CD8+ T cell differentiation and mouse embryogenesis A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Bioinformatics and Systems Biology by Kai Zhang Committee in charge: Professor Wei Wang, Chair Professor Pavel Arkadjevich Pevzner, Co-Chair Professor Vineet Bafna Professor Cornelis Murre Professor Bing Ren 2018 Copyright Kai Zhang, 2018 All rights reserved. The dissertation of Kai Zhang is approved, and it is accept- able in quality and form for publication on microfilm and electronically: Co-Chair Chair University of California San Diego 2018 iii EPIGRAPH The only true wisdom is in knowing you know nothing. —Socrates iv TABLE OF CONTENTS Signature Page ....................................... iii Epigraph ........................................... iv Table of Contents ...................................... v List of Figures ........................................ viii List of Tables ........................................ ix Acknowledgements ..................................... x Vita ............................................. xi Abstract of the Dissertation ................................. xii Chapter 1 General introduction ............................ 1 1.1 The applications of graph theory in bioinformatics ......... 1 1.2 Leveraging graphs to conduct integrated analyses .......... 4 1.3 References .............................. 6 Chapter 2 Systematic -
Effects of Depth of Incision on Final Outcome in Radial Keratotomy N
Effects of Depth of Incision on final outcome in Radial Keratotomy N. Raja, M. K. Niazi B-35, PAF Complex, Sector E-9, Islamabad. Abstract Objective: To assess the effect of depth of incision on the final outcome of radial keratotomy for correction of myopia. Methods: Sixty-five eyes with preoperative uncorrected myopia between 2.5-6.0D in subjects with a mean age of 29.2 (+7) years underwent radial keratotomy between Sept 1999--July 2002 in department of Ophthalmology, Military Hospital, Rawalpindi. Based on their preoperative depth of incision the eyes were divided into group-A (twenty-five eyes), with an incision depth of 500-530 µm, and Group-B (forty eyes), with an incision depth of 531- 560 µm. The comparison between the postoperative visual acuity of two groups was made at the end of study after one years` follow up. Results: A total of Sixteen eyes in Group-A (64%) that were within one diopter of emmetropia at first follow-up reverted back to their preoperative myopic state after one year of surgery as compared to only two eyes (5%) in Group-B (p<0.05). Hyperopic shift occurred in two eyes (8%) in Group-A, as compared to four eyes (10%) of Group-B (p >0.05). After one year, refraction showed that only 24% cases of Group-A were within 1 diopter of emmetropia as compared to 85% cases in Group-B. Similarly, 40% cases of Group-A were within 2 diopters of emmetropia as compared to 90% cases of Group-B. Glare and variation of vision in the initial four weeks were the most frequently reported complications in both groups. -
A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated. -
UCSF Ophthalmology Advice Guide Authors: Seanna Grob, MD, MAS
UCSF Ophthalmology Advice Guide Authors: Seanna Grob, MD, MAS and Neeti Parikh, MD Hello! We are excited that you are interested in ophthalmology! It is truly a special field in medicine. From saving someone’s vision after severe eye trauma, to restoring vision with cataract, retina, or cornea surgery, to preserving someone’s vision with glaucoma management and surgery, to reconstructing someone’s periocular area after trauma, burns, or tumor removal, amazing things can happen in ophthalmology. Ophthalmologists love their job and the majority say they would pick this specialty again if they had the choice. An incredible amount of job satisfaction comes from saving someone’s vision! We are here for you in the UCSF Department of Ophthalmology! We have put together this guide to help you through the process. This guide is meant to be very comprehensive. We want to make sure you are aware of all the opportunities and resources you have so that you can plan accordingly. You do not have to do everything we mention! Please feel free to reach out with questions about the specialty, how to get involved, and how to become a great ophthalmology applicant! 1 Medical School A well-rounded application is important for a successful match and any way you can prove to ophthalmology programs that you are dedicated to the field will be helpful to you. As more objective data (such as grades and board scores become less prevalent) other parts of your application will become more important. Various experiences you seek out are not only fun and educational, but will offer exposure to this wonderful field. -
ANTERIOR CORNEAL MOSAIC*T by A
Br J Ophthalmol: first published as 10.1136/bjo.52.9.659 on 1 September 1968. Downloaded from Brit. J. Ophthal. (1968) 52, 659 ANTERIOR CORNEAL MOSAIC*t BY A. J. BRON Moorfields Eye Hospital, City Road Branch, London THE corneal anatomy has received intensive study in recent years, but an aspect of its structure which is readily observed clinically has received little attention in the literature. In all normal corneae, after the instillation of fluorescein into the conjunctival sac, a striking mosaic pattern may be observed on the surface of the corneal epithelium after massage of the cornea through the lids. This pattern will be referred to as the anterior corneal mosaic. It was first observed by the author in patients whose eyes had been padded for corneal disease. It was noted in some that a mosaic pattern appeared after the instilla- tion of fluorescein. This pattern disappeared in a short period of time, but could readily be re-induced by pressure on the cornea through the lids. It is the purpose of this paper to describe the characteristics of the anterior corneal mosaic and to discuss its significance. This pattern was studied by Fischer (1928), and has since been re-studied by Schweitzer (1967). Methods Induction of the Mosaic A drop of 2 per cent. fluorescein is instilled into the conjunctival sac and the cornea is viewed with the cobalt beam of the slit lamp. If necessary the fluorescein is diluted to produce a bright fluorescence. A thumb is placed on the upper lid of the eye under examination and with the eye in the straight-ahead position, the lid is moved up and down over the cornea with light or moderate pressure applied to the globe.