Introduction Common Gynecologic Ailments Could Be Menstrual Period
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Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs Against Drug-Resistant Candida Sp
antibiotics Review Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp. Anna Herman 1,* and Andrzej Przemysław Herman 2 1 Faculty of Health Sciences, Warsaw School of Engineering and Health, Bitwy Warszawskiej 1920 18 Street, 02-366 Warsaw, Poland 2 Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-22-856-70-44; Fax: +48-22-646-34-18 Abstract: Clinical isolates of Candida yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective anti- fungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug- resistant Candida sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant Candida sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described. Citation: Herman, A.; Herman, A.P. Herbal Products and Their Active Keywords: herbalproducts; herbal active constituents; drug-resistant Candida sp.; antifungal drug Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp. -
Therapeutic Effects of Bossenbergia Rotunda
International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064 Index Copernicus Value (2015): 78.96 | Impact Factor (2015): 6.391 Therapeutic Effects of Bossenbergia rotunda S. Aishwarya Bachelor of Dental Surgery, Saveetha Dental College and Hospitals Abstract: Boesenbergia rotunda (L.) (Fingerroot), formerly known as Boesenbergia or Kaempferiapandurata (Roxb). Schltr. (Zingiberaceae), is distributed in south-east Asian countries, such as Indonesia, Malaysia and Thailand. The rhizomes of this plant have been used for the treatment of peptic ulcer, as well as colic, oral diseases, urinary disorders, dysentery and inflammation. As people have started to focus more on natural plants species for their curative properties. B. rotunda is a native ingredient in many Asian countries and is used as a condiment in food. It is also used as traditional medicine to treat several illnesses, consumed as traditional tonic especially after childbirth, beauty aid for teenage girls, and as a leukorrhea preventive remedy for women. Its fresh rhizomes are also used to treat inflammatory diseases, in addition to being used as an antifungal, antiparasitic, and aphrodisiac among Thai folks. Moreover, AIDS patients self-medicate themselves with B. rotunda to cure the infection. With the advancement in technology, the ethnomedicinal usages of herbal plants can be explained through in vitro and in vivo studies to prove the activities of the plant extracts. The current state of research on B. rotunda clearly shows that the isolated bioactive compounds have high potential in treating many diseases. Keywords: Zingerberaceae, anti fungal, anti parasitic, Chalcones, flavonoids. 1. Introduction panduratin derivative are prenylated flavonoids from B. pandurata that showed broad range of biological activities, Boesenbergia rotunda is a ginger species that grows in such as strong antibacterial acitivity9-11, anti- inflammatory Southeast Asia, India, Sri Lanka, and Southern China. -
Micropropagation-An in Vitro Technique for the Conservation of Alpinia Galanga
Available online a t www.pelagiaresearchlibrary.com Pelagia Research Library Advances in Applied Science Research, 2014, 5(3):259-263 ISSN: 0976-8610 CODEN (USA): AASRFC Micropropagation-an in vitro technique for the conservation of Alpinia galanga Nongmaithem M. Singh 1, Lukram A. Chanu 1, Yendrembam P. Devi 1, Wahengbam R.C. Singh 2 and Heigrujam B. Singh 2 1DBT-Institutional Biotech Hub, Pettigrew College, Ukhrul, Manipur 2DBT- Institutional Biotech Hub, Deptt. of Biotechnology, S.K. Women’s College, Nambol, Manipur _____________________________________________________________________________________________ ABSTRACT This study was conducted to develop an efficient protocol for mass propagation of Alpinia galanga L. Explants from rhizome buds were cultured on Murashige and Skoog (MS) medium supplemented with 6-Benzylaminopurine (BAP) alone (0 to 5 mg/l) or a combination of BAP (0 to 5 mg/l) and indole 3-acetic acid (IAA) (0 to 2 mg/l). MS medium supplemented with a combination of 5.0 mg/l BAP and 2.0 mg/l IAA or 3.0 mg/l BAP and 0.5 mg/l IAA produced the highest mean number of shoots per explant as compared to other concentrations. The best shoot length was obtained on the medium containing 1.0 mg/l of BAP and 2.0 mg/l IAA. Thus, combined effects of BAP and IAA improved significantly the shoot growth and proliferation. MS medium supplemented with a combination of 5.0 mg/l BAP and 2 mg/l IAA gave the highest number of roots. However, longest roots per explant were obtained with 1.0 mg/l BAP alone. -
C-23 Phytochemical of Kaempferia Plant And
Proceeding of International Conference On Research, Implementation And Education Of Mathematics And Sciences 2014, Yogyakarta State University, 18-20 May 2014 C-23 PHYTOCHEMICAL OF KAEMPFERIA PLANT AND BIOPROSPECTING FOR CANCER TREATMENT Sri Atun Chemistry education Faculty of Mathematical and Natural Science, Yogyakarta State University, Jl. Colombo No. 1 Yogyakarta, Indonesia, 55281 e-mail : [email protected] ABSTRACT Kaempferia genus is perennial member of the Zingiberaceae family and is cultivated in Indonesia and other parts of Southeast Asia. Number of studies has been conducted, providing information related to Kaempferia as antioxidant; antimutagenic; and chemopreventive agent. This paper reports some isolated compounds from this plant, biological activity, and bioprospecting for cancer treatment. Keyword: Cancer treatment; Kaempferia; Zingiberaceae INTRODUCTION Kaempferia is a genus, belong to family of Zingiberaceae. This plant grows in Southeast Asia, India, Sri Lanka, Indonesia, and Southem China. Kaempferia genus sinonim with Boesenbergia genus by Baker. This plant has 8 different botanical names which are Boesenbergia cochinchinensis (Gagnep.) Loes., Boesenbergia pandurata (Roxb.) Schltr., Curcuma rotunda L., Gastrochilus panduratus (Roxb.) Ridl., Gastrochilus rotundus (L.) Alston, Kaempferia cochinchinensis Gagnep., Kaempferia ovate Roscoe, Kaempferia galanga, Kaempferia rotunda, and Kaempferia pandurata Roxb nonetheless it is currently known as Boesenbergia rotunda (L.)Mansf (Tan Eng-Chong, et. al, 2012). The plants grown naturally in damp, shaded parts of the lowland or on hill slopes, as scattered plants or thickets. Economically important species among the plant families, the Zingiberaceae, which are perennial rhizomatous herbs, contain volatile oil and other important compounds of enormous medicinal values (Singh C.B., 2013). Phytochemical and biologycal activities of some species of Kaempferia Phytochemical and biologycal some species of plants of the genus Kaempferia reported by many researchers, among others: 1. -
Vasorelaxant Effect of Boesenbergia Rotunda and Its Active Ingredients
plants Article Vasorelaxant Effect of Boesenbergia rotunda and Its Active Ingredients on an Isolated Coronary Artery 1, 1, 1 1 2 Deepak Adhikari y, Dal-Seong Gong y, Se Hee Oh , Eun Hee Sung , Seung On Lee , Dong-Wook Kim 2, Min-Ho Oak 1,* and Hyun Jung Kim 1,* 1 College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun 58554, Korea; [email protected] (D.A.); [email protected] (D.-S.G.); [email protected] (S.H.O.); [email protected] (E.H.S.) 2 Department of Oriental Medicine Resources, Mokpo National University, Muan-gun 58554, Korea; [email protected] (S.O.L.); [email protected] (D.-W.K.) * Correspondence: [email protected] (M.-H.O.); [email protected] (H.J.K.); Tel.: +82-61-450-2681 (M.-H.O.); +82-61-450-2686 (H.J.K.) The authors contributed to this work equally. y Received: 4 November 2020; Accepted: 27 November 2020; Published: 1 December 2020 Abstract: Cardiovascular diseases are a major cause of death in developed countries. The regulation of vascular tone is a major approach to prevent and ameliorate vascular diseases. As part of our ongoing screening for cardioprotective natural compounds, we investigated the vasorelaxant effect of rhizomes from Boesenbergia rotunda (L.) Mansf. [Boesenbergia pandurata (Roxb.) Schltr.] used as a spice and herbal medicine in Asian countries. The methanol extract of B. rotunda rhizomes (BRE) exhibited significant vasorelaxation effects ex vivo at EC values of 13.4 6.1 µg/mL and 40.9 7.9 µg/mL, 50 ± ± respectively, with and without endothelium in the porcine coronary artery ring. -
2018-01-26 Langual Proposal from Foodex2 – Plants in Facet B
2018-01-26 LanguaL proposal from FoodEx2 – plants in facet B The following are proposals to update LanguaL Facet B, after having indexed EFSA FoodEx2 Exposure hierarchy 20170919. To these, I have added previously-submitted 2017 proposals based on GS1 that have not (yet) been included in LanguaL facet B. GS1 terms and FoodEx2 terms in the following tables are just given to indicate the origin of the proposal. Comments are given in red. First, some simple additions of terms to the SYNONYM field, to make it easier to find descriptors in the LanguaL Food Product Indexer: descriptor synonyms FoodEx2 term FoodEx2 def WORMWOOD [B3433] Add SYN: artemisia vulgaris LITTLE RADISH [B2960] Add SYN: raphanus sativus BLACK RADISH [B2959] Add SYN: raphanus sativus niger PARSNIP [B1483] Add SYN: pastinaca sativa ARRACACHA [B3439] Add SYN: arracacia xanthorrhiza CHAYOTE [B1730] Add SYN: GS1 10006356 - Squash Squash, Choko, grown from Sechium edule (Choko) choko NEW ZEALAND SPINACH Add SYN: GS1 10006427 - New- Tetragonia tetragonoides Zealand Spinach [B1732] tetragonia tetragonoides JAPANESE MILLET Add : barnyard millet; A000Z Barnyard millet Echinochloa esculenta (A. Braun) H. Scholz, Barnyard millet or Japanese Millet. [B4320] echinochloa esculenta INDIAN LONG PEPPER Add SYN! A019B Long pepper fruit Piper longum [B2956] piper longum EUROPEAN ELDER Modify SYN: [B1403] sambucus spp. (which refers to broader term) Should be sambucus nigra DOG ROSE [B2961] ADD SYN: rosa canina LOOSE LEAF LETTUCE Add SYN: [B2087] lactusa sativa L. var. crispa LOLLO ROSSO [B2088] Add SYN: GS1 10006425 - Lollo Lactuca sativa L. var. crispa Rosso red coral lettuce JAVA APPLE [B3395] Add syn! syzygium samarangense Some existing descriptors would also greatly benefit from updated AI (and synonyms): FoodEx2 FoodEx2 def descriptor AI synonyms term ENDIVE [B1314] Add to AI: A00LD Escaroles There are two main varieties of cultivated C. -
Mansf. and Myristica Fragrans Houtt. Against Helicobacter Pylori
Antibacterial activity of Boesenbergia rotunda (L.) Mansf. and Myristica fragrans Houtt. against Helicobacter pylori Sutatip Bhamarapravati1, Siriyaporn Juthapruth2, Warocha Mahachai3 and Gail Mahady4 Abstract Bhamarapravati, S., Juthapruth, S., Mahachai, W. and Mahady, G. Antibacterial activity of Boesenbergia rotunda (L.) Mansf. and Myristica fragrans Houtt. against Helicobacter pylori Songklanakarin J. Sci. Technol., 2006, 28(Suppl. 1) : 157-163 Helicobacter pylori, a gram-negative bacterium, is recognized as the primary etiological agent for the development of gastritis, dyspepsia, peptic ulcer as well as gastric and colon cancer. In developing countries the incidence of H. pylori infection ranges from 50-100%. Two Thai plants, namely Boesenbergia rotunda (L.) Mansf. and Myristica fragrans Houtt., have been used to treat dyspepsia and peptic ulcer in Thai Traditional Medicine. Their crude extracts were previously reported to possess anti- H. pylori activity. This investigation proposed to test previously isolated bioactive compounds from B. rotunda and M. fragrans if they possessed anti- H. pylori activity. Primary cultures of H. pylori from local hospital patients in Thailand were used in the investigation. In vitro anti- H. pylori testing had been performed with pinostrobin and red oil from roots of B. rotunda, and dihydroguaiaretic acid from arils of M. fragrans. Clarithromycin (MIC 120 µg/mL) was used as a positive control. All three compounds showed positive clear zone in agar diffusion test at p<0.05 in all 1Department of Graduate Studies, Faculty of Medicine, Thammasat University, Pathum Thani, 12121 Thai- land. 2M.Sc. student in Microbiology, Faculty of Science, 3MD., Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 Thailand. -
Inhibition of Nitric Oxide Production by Compounds from Boesenbergia Longiflora Using Lipopolysaccharide-Stimulated RAW264.7 Macrophage Cells
Songklanakarin J. Sci. Technol. 35 (3), 317-323, May - Jun. 2013 http://www.sjst.psu.ac.th Original Article Inhibition of nitric oxide production by compounds from Boesenbergia longiflora using lipopolysaccharide-stimulated RAW264.7 macrophage cells Teeratad Sudsai1,2, Chatchai Wattanapiromsakul1, and Supinya Tewtrakul1, 2* 1Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, 2Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand. Received 12 October 2012; Accepted 17 January 2013 Abstract The inhibitory activity of extract and compounds isolated from Boesenbergia longiflora against nitric oxide (NO) was evaluated using RAW264.7 cells. Isolation of the chloroform extract of B. longiflora rhizomes afforded four known flavonoids, which were identified as kaempferol-3,7,4'-trimethyl ether (1), kaempferol-7,4'-dimethyl ether (2), rhamnazin (3), pinostrobin (4), together with four known diarylheptanoids, dihydrobisdemethoxycurcumin (5), curcumin (6), demethoxy- curcumin (7) and bisdemethoxycurcumin (8), as well as one sterol, -sitosterol-D-glucoside (9). Compound 6 exhibited the highest inhibitory activity against NO release with an IC50 value of 4.5 µM, followed by 7 (IC50 = 11.7 µM), 8 (IC50 = 15.7 µM), 5 (IC50 = 23.0 µM) and 1 (IC50 = 23.5 µM), respectively. This study demonstrated that diarylheptanoids and some methoxy- flavonoids found in B. longiflora are responsible for anti-inflammatory activity and this is the first report the safety, chemical constituents and biological activity of this plant. Keywords: Zingiberaceae, anti-inflammatory effect, diarylheptanoids, methoxyflavonoids 1. Introduction matory, anticancer, and anti-HIV activities. Cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin The genus Boesenbergia, a member of the A, the active constituents isolated from B. -
A Review on the Ethnomedicinal Uses, Phytochemistry and Pharmacology of Plant Species Belonging to Kaempferia L
Pharmaceutical Sciences Asia Pharm Sci Asia 2021; 48(1), 1-24 DOI:10.29090/psa.2021.01.19.070 Review A review on the ethnomedicinal uses, phytochemistry and pharmacology of plant species belonging to Kaempferia L. genus (Zingiberaceae) Ngoc Khanh Pham1,2,3*, Hoang Tuan Nguyen2, Quoc Binh Nguyen4 ABSTRACT 1 Institute of Natural Products Chemistry Kaempferia L. is a genus commonly distributed in Asian (INPC), Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam countries including China, India, Thailand, Myanmar, Malaysia, 2 Hanoi University of Pharmacy, Hoan Kiem, Indonesia, Laos, Cambodia and Vietnam, where these species are Hanoi, Vietnam popularly used as traditional medicines for different ailments 3 College of Pharmacy, Dongguk University, Goyang, Korea comprising infective diseases, wound infection, cough, pain and 4 Vietnam National Museum of Nature, digestion disorders on chemical composition of Kaempferia plants Vietnam Academy of Science and revealed the presence of natural compounds classified in Technology, Cau Giay, Hanoi, Vietnam monoterpenoids, diterpenoids, flavonoids, phenolic glycosides, cyclohexane oxide derivatives, diarylheptanoids and essential oil with *Corresponding author: various biological properties, which are valuable for discovery of new Ngoc Khanh Pham natural-derived therapeutic drugs and applications for the human [email protected] beings. This study is aimed to review the chemical, ethnobotanical and pharmacological properties of the plants belonging to Kaempferia genus growing in Asian countries and especially in South East Asia. 1. INTRODUCTION Kaempferia, is a medium - sized genus of about 60 plant species belonging to Zingiberaceae1 that is one of the major tropical plant families with many members commonly used as ornaments, 2 spices and as medicinal herbs . -
Ethnobotany in Upper Northeastern Thailand
Ethnobotany in Upper Northeastern Thailand Seewapong Chamratpan Sam-ang Homchuen Faculty of Science and Technology Department of Environmental Science Rajabhat Institute Udon Thani Faculty of Science, Khon Kaen University Udon Thani, 41000 Khon Kaen, 40002 Thailand Thailand Keywords: colon cancer, decoction, herpes, medicinal massage, paralysis, snake bite Abstract Some rural people residing in the villages of upper northeastern Thailand still use herbs for preventing and curing many diseases. According to the interviews from traditional healers and elders living in seven villages in three provinces of Thailand, the medicinal plants are used in five ways – used as a rubbing or poultice, a decoction, an alcoholic tincture, a massage or eaten fresh. Rubbing is the common application used for plants such as; (1) slender amaranth (Amaranthus viridis) leaf is applied for removing pain, reducing swelling and pain of insect bites, (2) crushed hophead Philippine violet (Barleria lupulina) and phaya yo (Clinacanthus nutans) are applied for herpes (ngu-swat), (3) immature dry black fruit of sugar apple (Annona squamosa) called mummy is scrubbed and externally applied on suppurated skin as an effective suppurant. Examples of the fresh ingestion or similar methods are – (1) crushed fresh Siam weed (Chromolaena odorata) leaf with alum is chewed and applied on the wound as an antidote for snake bite, (2) veld grape (Cissus quadrangularis) vine with ripe tamarind pulp is eaten for curing hemorrhoids, (3) root and vine of khruea sai tan (Aganosma marginata) is eaten to get rid of schizophrenia. An example of a decoction is khi non (Uraria crinita) which is an effective remedy for severe colon cancer. -
Mansf. and Curcuma Zedoaria Rosc Against Dengue Vector Mosquito, Aedes Aegypti L
International Journal of Agricultural Technology 2013 Vol. 9(6):1573-1583 International Journal of AgriculturalAvailable Technology online http://www.ijat 2013, Vol. 9(-6)aatsea.com:1573-1583 ISSN 2630-0192 (Online) Insecticidal effect of essential oils from Boesenbergia rotunda (L.) Mansf. and Curcuma zedoaria rosc against dengue vector mosquito, Aedes aegypti L. Phukerd, U.* and Soonwera, M. Plant Production Technology Section, Faculty of Agricultural Technology, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand Phukerd, U. and Soonwera, M. (2013) Insecticidal effect of essential oils from Boesenbergia rotunda (L.) Mansf. and Curcuma zedoaria rosc against dengue vector mosquito, Aedes aegypti L. International Journal of Agricultural Technology 9(6):1573-1583. Abstract Essential oils from two Thai herbal plants, Boesenbergia rotunda (L.) Mansf. and Curcuma zedoaria Rosc were evaluated for their larvicidal, pupicidal, oviposition-deterrent potential against Dengue Vector Mosquito, Aedes aegypti L.. The larval mortality was recorded at 1, 5, 10, 15, 30, 60 minutes and 24 hours while pupal mortality was recorded at 15, 30 minutes, 1, 3, 6, 12, 24 and 48 hours. The results revealed that C. zedoaria essential oil proved to have greater toxicity against Ae. aegypti larvae and pupae with LC50 value of 0.05% and 1.22%, respectively The essential oil of C. zedoaria exhibited higher larvicide activity than B. rotunda essential oil with LT50 of 40.1, 3.2 and <1.0 minutes at 1, 5 and 10% conc., respectively. It was consistent with pupicidal activity which exhibited LT50 values of 23.1, 1.3 and 0.5 hours at 1, 5 and 10% conc., respectively. -
Anti-Allergic Activity of Some Selected Plants in the Genus Boesenbergia and Kaempferia
Songklanakarin J. Sci. Technol. 33 (3), 301-304, May - Jun. 2011 http://www.sjst.psu.ac.th Short Communication Anti-allergic activity of some selected plants in the genus Boesenbergia and Kaempferia Fameera Madaka and Supinya Tewtrakul* Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand. Received 2 June 2011; Accepted 30 June 2011 Abstract Ethanolic and water extracts from the rhizomes of eight selected Zingiberaceous plants, including Boesenbergia thorelii, Boesenbergia sp 1, Boesenbergia sp 2, Boesenbergia sp 3, Kaempferia angustifolia, Kaempferia marginata, Kaempferia rotunda and Kaempferia sp were tested for their anti-allergic activities using the rat basophilic leukemia strain 2H3 (RBL-2H3) cell line. Both the ethanolic (EtOH) and water extracts of Boesenbergia thorelii exhibited the most potent anti-allergic effects against antigen-induced â-hexosaminidase release as a marker of degranulation in RBL-2H3 cells, with IC50 values of 23.0 and 26.3 g/ml, respectively. Other extracts also had some activity from Boesenbergia sp 2 (EtOH, IC50 = 38.3 g/ml), Kaempferia marginata (water, IC50 = 38.4 g/ml), Boesenbergia sp 3 (EtOH, IC50 = 49.4 g/ml) and Kaempferia angustifolia (water, IC50 = 55.6 g/ml), whereas other Boesenbergia and Kaempferia spp had little or no activity. These find- ings support the use of Boesenbergia thorelii for the treatment of allergies and allergy-related diseases. Keywords: RBL-2H3 cells, anti-allergic activity, Zingiberaceae 1. Introduction spores, and pollen. This class of antigen induces the produc- tion of antigen-specific IgE antibodies that bind to receptors The Zingiberaceae is among the plant families which on mast cells or basophils (Matsuda et al., 2004).