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Eukaryotic DNA Replication & Genome Maintenance

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Eukaryotic DNA Replication & Genome Maintenance Eukaryotic DNA Replication & Genome Maintenance Session 1 NEW APPROACHES AND PERSPECTIVES MONDAY 9/9/2013, 7:30 PM A. van Oijen / K. Labib # lname Title Talk Length 1 van Oijen Single-molecule studies of DNA replication 12 2 Remus Origin specificity during budding yeast DNA replication in vitro 12 3 Urban Mapping DNA replication origins in the human genome 12 4 Mechali DNA replication origins profiling—Genetic and epigenetic features, and relationships with cell 12 identity 5 Ni Subunits of the origin recognition complex bind BubR1 and are essential for kinetochore function 12 during mitosis in human cells 6 Labib Regulation of the replisome by ubiquitin and SUMO 12 7 Koren Random replication of the inactive X chromosome 12 8 Xie Replication-dependent DNA fragility and adaptive evolution in natural populations 12 9 Raghuraman Replication origins and the generation of palindromic amplifications in yeast 12 10 Dutta MicroDNAs and microdeletions—Genomic instability in vertebrate cells 12 Session 2 ORIGIN SELECTION AND LICENSING TUESDAY 9/10/2013, 9:00 AM M. Aladjem / S. Bell # lname Title Talk Length 11 Aladjem Regulatory interactions governing replication initiation patterns in human cells 12 12 Petryk Sequencing of Okazaki fragments allows determination of replication fork polarity and origin 12 location and efficiency in the human genome 13 Debatisse Chk1 or Rad51 deficiency perturbs replication dynamics via p53R2-mediated modulation of dNTP 12 availability 14 Liachko Dual modes of DNA replication initiation in the methylotrophic yeast Pichia pastoris 12 15 Bleichert A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin 12 recognition complex formation 16 Li One ORC with many faces—The yeast ORC changes conformation as it sequentially binds to 12 DNA, is activated by Cdc6, and loads the Mcm2-7 hexamer 17 Weinreich Genetic and biochemical analyses of Cdc6 Walker B mutants yields insight into the mechanism of 12 pre-RC assembly 18 Bell Mcm2-7 ATP-binding and hydrolysis functions at multiple steps during replication initiation 12 19 Speck Biochemical dissection of the MCM2-7 loading reaction 12 20 Coster ATP binding and hydrolysis by the eukaryotic replicative helicase play distinct roles during origin 12 licensing Page 1 of 11 Session 3 POSTER SESSION I TUESDAY 9/10/2013, 2:00 PM # lname Title Talk Length 21 Ahuja DNA replication stress in stem cells? 22 Alexander Causes and consequences of altered replication fork progression during Drosophila follicle cell gene amplification 23 Alvino Rif1 deletion causes partial bypass of DDK-mediated origin activation in Saccharomyces cerevisiae 24 Anastassiadis Oncogenic stress sensitizes cancers to hypomorphic suppression of ATR 25 Azar Prolonged blockade in G2 phase through inhibition of CDK1 permits firing of latent origins and abolishes instability of common fragile sites 26 Azeroglu DNA synthesis during double strand break repair in Escherichia coli 27 Badu-Nkansah Functions of annealing helicases in replication fork repair and restart 28 Bailey PrimPol, a eukaryotic primase-polymerase involved in TLS replication after UV damage in the nucleus, and mitochondrial DNA maintenance 29 Balasov Orc6 protein has functions in DNA replication and cytokinesis 30 Becker Composite PCNA ubiquitination patterns in DNA replication mutants ATM 31 Bianchi Tel1 dictates the replication timing of short telomeres in yeast 32 Billmire Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication 33 Blow Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts 34 Boos MTBP is a novel interactor of Treslin/ticrr required for the initiation of DNA replication in human cells 35 Brustel New insights into the epigenetic control of DNA replication by histone methylation 36 Cadoret Study of the genetic instability due to a defect in DNA replication—Characterization of pause replication sites in the human genome 37 Cerritelli RNase H2 processes ribonucleotides incorporated in DNA by replicative and translesion DNA polymerases 38 Chen Repair-specific functions of replication protein A Cdt2 39 Cook Simultaneous stabilization of CRL4 targets in mitosis 40 Corda The H3K56 acetylation pathway goes through Ctf4 to deal with replicative damages by regulating replisome integrity 41 Cussiol Coordination of checkpoint signaling and DNA repair via the Dpb11 scaffold 42 Das The number of MCM loaded at origins regulate replication timing in budding yeast Page 2 of 11 43 DePamphilis The dual role of Geminin during preimplantation mammalian development 44 Dhingra Investigating the interaction of Dpb11 with Mcm2-7 and DNA 45 Ding Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair 46 Douglas Investigating the role of Mcm10 in DNA replication 47 Dukaj Real-time, single-molecule analysis of replication fork kinetics in frog extracts 48 Dunlop Genome wide analysis of CDC45 and DNA polymerases during S phase in HeLa S3 cells 49 Eckert The cooperation of multiple DNA polymerases is required for efficient replication of human genome common fragile sites 50 Elias Identification of a late origin of replication in Trypanosoma brucei chromosome 1 51 Fernandez Vidal A new role for the human DNA polymerase Theta in the regulation of the timing of origins activation 52 Fragkos Small non-coding RNA is required for the assembly of replication pre-initiation complexes and origin activation in Xenopus laevis 53 Franz Dynamic chromatin association of replication factors requires the ubiquitin-selective segregase CDC-48 (p97/VCP) 54 Froelich Oligomerization of the MCM helicase Timeless 55 Gadaleta Swi1 prevents DNA damage during replication of difficult-to-replicate sites 56 Gambus The role of Mcm7 ubiquitylation during termination of eukaryotic DNA replication 57 Garbacz Investigating the function of a conserved insertion in the catalytic subunit of DNA polymerase ε 58 Ge Embryonic stem cells license more dormant replication origins to ensure genomic integrity and differentiation 59 Georgescu CMG and replication fork polymerases—Interplay among component activities 60 Ghospurkar The N-terminal domain of Rfa2 in Saccharomyces cerevisiae is necessary, but its phosphorylation is not required, for the response to DNA damage 61 Gomez-Gonzalez Deciphering the role of S-phase checkpoints in the stabilization of replication forks 62 Greenwalt Polη-dependent translesion synthesis—A novel target for cancer therapy 63 Greven Examining the correlation between nucleosome turnover and replication timing 64 Guarne The FHA1 domain of Rad53 recognizes Dbf4 through a distinct non-canonical interface 65 Gunes Whole genome iRNA screening identifies aneuploidy-inducing gene knockdowns and telomerase- activation as an aneuploidy survival mechanism in human cells 66 Handa Shugoshin 2 participates in replication timing control in telomere and centromere in fission yeast 67 Herrera Sld2 and Sld3 promote DDK dependent Cdc45 loading during pre-IC formation 68 Hesketh How is mammalian MCM assembled into a functional complex? Page 3 of 11 69 Higashi Essential roles of the N-terminal region of XEco2 acetyltransferase for cohesion establishment in Xenopus egg extracts 70 Hiraga Rif1 controls DNA replication genome-wide by opposing Cdc7-Dbf4-mediated phosphorylation through protein phosphatase 1 71 Hizume DNA replication licensing on the chromatin fiber—Visualization by atomic force microscopy 72 Hoggard Using genome-wide ORC-DNA binding data to explore mechanisms that help define in vivo ORC binding sites, MCM loading sites, and functional origins 73 Hossain Rb and cyclin-dependent protein kinase control of ORC and Cdc6 in human cells 74 Hua Mechanisms of origin activation and repression during Drosophila gene amplification 75 Hustedt Genetic and physical interaction between the ATR kinase and PP4 phosphatase in yeast 76 Hyrien DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts 77 Im ATR-dependent checkpoint pathway represses the transcription of genes overlapping with doxorubicin-induced clusters of stalled replication forks 78 Indiani A new action of RecA—A traffic cop for DNA polymerases at the replication fork 79 Ivanov How is the establishment of sister chromatid cohesion coupled to DNA replication? 80 Jagannathan The p38-MK2 pathway in replicative stress response to anti-metabolites 81 Jeffery The role of Cac1p in the epigenetic conversions of sub-telomeres in S. cerevisiae 82 Jiang The potential function of zebrafish Udu and its human ortholog, GON4L, in DNA replication 83 Kanemaki The Mcm8-9 complex promotes DNA synthesis after strand invasion in recombination repair 84 Kao Coordinated chromatin assembly by H2B ubiquitylation maintains fork progression and stability during replication stress 85 Kaplan The replication initiation protein Sld2 regulates helicase assembly 86 Kawasoe Evidence that DNA-loaded PCNA acts as the strand marker for eukaryotic mismatch repair 87 Kerem The molecular basis for replication-induced DNA damage in early stages of cancer development 88 Kilkenny Structures of human primase reveal architecture of nucleotide elongation site and mode of Pol α tethering 89 Kim Balancing act of DNA repeat expansions—Investigating large-scale CAG/CTG repeat expansions in budding yeast 90 Klingbeil Regulation of mitochondrial DNA replication 91 Koren Common variation in the DNA replication timing program of the human genome 92 Koundrioukoff Stepwise
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