Eukaryotic DNA Replication & Genome Maintenance

Session 1 NEW APPROACHES AND PERSPECTIVES MONDAY 9/9/2013, 7:30 PM A. van Oijen / K. Labib # lname Title Talk Length 1 van Oijen Single-molecule studies of DNA replication 12 2 Remus Origin specificity during budding yeast DNA replication in vitro 12 3 Urban Mapping DNA replication origins in the 12 4 Mechali DNA replication origins profiling—Genetic and epigenetic features, and relationships with cell 12 identity 5 Ni Subunits of the origin recognition complex bind BubR1 and are essential for kinetochore function 12 during mitosis in human cells 6 Labib Regulation of the replisome by ubiquitin and SUMO 12 7 Koren Random replication of the inactive X 12 8 Xie Replication-dependent DNA fragility and adaptive evolution in natural populations 12 9 Raghuraman Replication origins and the generation of palindromic amplifications in yeast 12 10 Dutta MicroDNAs and microdeletions—Genomic instability in vertebrate cells 12

Session 2 ORIGIN SELECTION AND LICENSING TUESDAY 9/10/2013, 9:00 AM M. Aladjem / S. Bell # lname Title Talk Length 11 Aladjem Regulatory interactions governing replication initiation patterns in human cells 12 12 Petryk Sequencing of Okazaki fragments allows determination of replication fork polarity and origin 12 location and efficiency in the human genome 13 Debatisse Chk1 or Rad51 deficiency perturbs replication dynamics via p53R2-mediated modulation of dNTP 12 availability 14 Liachko Dual modes of DNA replication initiation in the methylotrophic yeast Pichia pastoris 12 15 Bleichert A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin 12 recognition complex formation 16 Li One ORC with many faces—The yeast ORC changes conformation as it sequentially binds to 12 DNA, is activated by Cdc6, and loads the Mcm2-7 hexamer 17 Weinreich Genetic and biochemical analyses of Cdc6 Walker B mutants yields insight into the mechanism of 12 pre-RC assembly 18 Bell Mcm2-7 ATP-binding and hydrolysis functions at multiple steps during replication initiation 12 19 Speck Biochemical dissection of the MCM2-7 loading reaction 12 20 Coster ATP binding and hydrolysis by the eukaryotic replicative helicase play distinct roles during origin 12 licensing Page 1 of 11

Session 3 POSTER SESSION I TUESDAY 9/10/2013, 2:00 PM

# lname Title Talk Length 21 Ahuja DNA replication stress in stem cells? 22 Alexander Causes and consequences of altered replication fork progression during Drosophila follicle cell amplification 23 Alvino Rif1 deletion causes partial bypass of DDK-mediated origin activation in Saccharomyces cerevisiae 24 Anastassiadis Oncogenic stress sensitizes cancers to hypomorphic suppression of ATR 25 Azar Prolonged blockade in G2 phase through inhibition of CDK1 permits firing of latent origins and abolishes instability of common fragile sites 26 Azeroglu DNA synthesis during double strand break repair in Escherichia coli 27 Badu-Nkansah Functions of annealing helicases in replication fork repair and restart 28 Bailey PrimPol, a eukaryotic primase-polymerase involved in TLS replication after UV damage in the nucleus, and mitochondrial DNA maintenance 29 Balasov Orc6 has functions in DNA replication and cytokinesis 30 Becker Composite PCNA ubiquitination patterns in DNA replication mutants ATM 31 Bianchi Tel1 dictates the replication timing of short telomeres in yeast 32 Billmire Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication 33 Blow Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts

34 Boos MTBP is a novel interactor of Treslin/ticrr required for the initiation of DNA replication in human cells 35 Brustel New insights into the epigenetic control of DNA replication by histone methylation 36 Cadoret Study of the genetic instability due to a defect in DNA replication—Characterization of pause replication sites in the human genome 37 Cerritelli RNase H2 processes ribonucleotides incorporated in DNA by replicative and translesion DNA polymerases 38 Chen Repair-specific functions of replication protein A Cdt2 39 Cook Simultaneous stabilization of CRL4 targets in mitosis 40 Corda The H3K56 acetylation pathway goes through Ctf4 to deal with replicative damages by regulating replisome integrity 41 Cussiol Coordination of checkpoint signaling and DNA repair via the Dpb11 scaffold 42 Das The number of MCM loaded at origins regulate replication timing in budding yeast Page 2 of 11 43 DePamphilis The dual role of Geminin during preimplantation mammalian development 44 Dhingra Investigating the interaction of Dpb11 with Mcm2-7 and DNA 45 Ding Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair 46 Douglas Investigating the role of Mcm10 in DNA replication 47 Dukaj Real-time, single-molecule analysis of replication fork kinetics in frog extracts 48 Dunlop Genome wide analysis of CDC45 and DNA polymerases during S phase in HeLa S3 cells 49 Eckert The cooperation of multiple DNA polymerases is required for efficient replication of human genome common fragile sites 50 Elias Identification of a late origin of replication in Trypanosoma brucei chromosome 1 51 Fernandez Vidal A new role for the human DNA polymerase Theta in the regulation of the timing of origins activation

52 Fragkos Small non-coding RNA is required for the assembly of replication pre-initiation complexes and origin activation in Xenopus laevis 53 Franz Dynamic chromatin association of replication factors requires the ubiquitin-selective segregase CDC-48 (p97/VCP) 54 Froelich Oligomerization of the MCM helicase Timeless 55 Gadaleta Swi1 prevents DNA damage during replication of difficult-to-replicate sites

56 Gambus The role of Mcm7 ubiquitylation during termination of eukaryotic DNA replication 57 Garbacz Investigating the function of a conserved insertion in the catalytic subunit of DNA polymerase ε

58 Ge Embryonic stem cells license more dormant replication origins to ensure genomic integrity and differentiation 59 Georgescu CMG and replication fork polymerases—Interplay among component activities 60 Ghospurkar The N-terminal domain of Rfa2 in Saccharomyces cerevisiae is necessary, but its phosphorylation is not required, for the response to DNA damage 61 Gomez-Gonzalez Deciphering the role of S-phase checkpoints in the stabilization of replication forks 62 Greenwalt Polη-dependent translesion synthesis—A novel target for cancer therapy 63 Greven Examining the correlation between nucleosome turnover and replication timing 64 Guarne The FHA1 domain of Rad53 recognizes Dbf4 through a distinct non-canonical interface 65 Gunes Whole genome iRNA screening identifies aneuploidy-inducing gene knockdowns and telomerase- activation as an aneuploidy survival mechanism in human cells 66 Handa Shugoshin 2 participates in replication timing control in telomere and centromere in fission yeast

67 Herrera Sld2 and Sld3 promote DDK dependent Cdc45 loading during pre-IC formation 68 Hesketh How is mammalian MCM assembled into a functional complex?

Page 3 of 11 69 Higashi Essential roles of the N-terminal region of XEco2 acetyltransferase for cohesion establishment in Xenopus egg extracts 70 Hiraga Rif1 controls DNA replication genome-wide by opposing Cdc7-Dbf4-mediated phosphorylation through protein phosphatase 1 71 Hizume DNA replication licensing on the chromatin fiber—Visualization by atomic force microscopy 72 Hoggard Using genome-wide ORC-DNA binding data to explore mechanisms that help define in vivo ORC binding sites, MCM loading sites, and functional origins 73 Hossain Rb and cyclin-dependent protein kinase control of ORC and Cdc6 in human cells 74 Hua Mechanisms of origin activation and repression during Drosophila gene amplification

75 Hustedt Genetic and physical interaction between the ATR kinase and PP4 phosphatase in yeast 76 Hyrien DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts 77 Im ATR-dependent checkpoint pathway represses the transcription of overlapping with doxorubicin-induced clusters of stalled replication forks 78 Indiani A new action of RecA—A traffic cop for DNA polymerases at the replication fork 79 Ivanov How is the establishment of sister chromatid cohesion coupled to DNA replication? 80 Jagannathan The p38-MK2 pathway in replicative stress response to anti-metabolites 81 Jeffery The role of Cac1p in the epigenetic conversions of sub-telomeres in S. cerevisiae 82 Jiang The potential function of zebrafish Udu and its human ortholog, GON4L, in DNA replication 83 Kanemaki The Mcm8-9 complex promotes DNA synthesis after strand invasion in recombination repair

84 Kao Coordinated chromatin assembly by H2B ubiquitylation maintains fork progression and stability during replication stress 85 Kaplan The replication initiation protein Sld2 regulates helicase assembly 86 Kawasoe Evidence that DNA-loaded PCNA acts as the strand marker for eukaryotic mismatch repair 87 Kerem The molecular basis for replication-induced DNA damage in early stages of cancer development

88 Kilkenny Structures of human primase reveal architecture of nucleotide elongation site and mode of Pol α tethering 89 Kim Balancing act of DNA repeat expansions—Investigating large-scale CAG/CTG repeat expansions in budding yeast 90 Klingbeil Regulation of mitochondrial DNA replication 91 Koren Common variation in the DNA replication timing program of the human genome 92 Koundrioukoff Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity 93 Kowalski Non-coding nematode stem-bulge RNAs can initiate DNA replication

Page 4 of 11 94 Krude Non-coding Y RNAs dynamically associate with early-replicating euchromatin during S phase

95 Kumar Epigenetic control of origin licensing during mammalian DNA replication 96 Lamers Architecture of the Pol III-clamp-exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair 97 Langley Genome-wide mapping of ORC2 binding sites and active DNA replication origins at the G1 to S phase transition in human cell nuclei 98 Lemaitre Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs 99 Liang An essential, cell cycle-dependent and semi-conservative ORC dimerization cycle critically regulates DNA replication 100 Lim DNA- and protein-interacting properties of the mammalian 9-1-1 checkpoint clamp subunit HUS1

101 Liu A conserved TopBP1-mediated interaction network with functions in the DNA damage response

102 Long A novel role for BRCA1 in DNA interstrand cross-link repair 103 Lygerou Multi-step loading of mini chromosome maintenance in live human cells 104 Lygerou Stochastic hybrid modeling of DNA re-replication across a complete genome reveals genome plasticity 105 Lyles Investigating the role of eukaryotic DNA replication in the establishment and maintenance of recombinant adeno-associated viral vector genomes in vitro and in vivo

Session 4 CHROMATIN AND REPLICATION TUESDAY 9/10/2013, 7:30 PM A. Groth / Z. Zhang # lname Title Talk Length 106 Groth Chromatin replication and epigenome maintenance 12 107 Belsky Genome-wide chromatin footprinting reveals dynamics of origin architecture during pre-RC 12 assembly 108 Whitehouse Using the lagging strand to study chromatin assembly 12 109 Fujita Cdt1-binding protein GRWD1 is a novel histone chaperone that regulates chromatin structure and 12 MCM loading 110 Pasero The HDACs Rpd3 and Sir2 control replication timing in budding yeast by regulating the activity of 12 rDNA origins 111 Zhang Histone modifications regulate DNA replication coupled nucleosome assembly 12 112 Kubota Does Elg1 link PCNA unloading with histone deposition during DNA replication? 12 113 Li Drosophila PR-Set7 and H4K20 methylation are required for S-phase progression but not 12 origin activation 114 Lee Regulation of the S phase checkpoint by chromatin remodelers 12 115 Nordman Repression of DNA replication through inhibition of replication fork progression 12 Page 5 of 11 Session 5 ORIGIN ACTIVATION AND TIMING WEDNESDAY 9/11/2013, 9:00 AM H. Araki / H. Masukata # lname Title Talk Length 116 Araki Formation of active replicative helicase in budding yeast 12 117 Deegan Investigating the mechanism of Sld3/7 recruitment to the pre-RC 12 118 Chadha Dissecting Cdc7- and CDK-dependent steps in replication initiation in Xenopus egg extract 12 119 Sheu A domain of the helicase subunit Mcm4 integrates multiple kinase regulatory systems to control 12 DNA replication initiation and fork progression 120 Leffak Activation of a human chromosomal replication origin by protein tethering 12 121 Masukata Replication timing control by chromatin proteins 12 122 Rhind Replication timing is regulated by the number of MCMs loaded at origins 12 123 Fox A link between ORC-origin binding mechanisms and origin activation time revealed in budding 12 yeast 124 Carlomagno NCOA4 transcriptional coactivator inhibits activation of DNA replication origins 12 125 Grosse Unscheduled expression of Cdc45 leads to replicative stress, DNA damage, and subsequent 12 apoptosis

Session 6 POSTER SESSION II WEDNESDAY 9/11/2013, 2:00 PM

# lname Title Talk Length Dia2 126 Maculins SCF drives disassembly of the Cdc45-MCM-GINS helicase 127 Marheineke Global regulation of origin activation by Chk1 in the Xenopus in vitro system 128 Maric Ubiquitylation of Cdc45-MCM-GINS DNA helicase is coupled to Cdc48-dependent disassembly during completion of chromosome replication 129 Marino The N-terminus of human and Xenopus RecQ4 contains a putative zinc-knuckle domain 130 Matsumoto Checkpoint-independent regulation of initiation at replication origins in fission yeast by Mrc1

131 Mazurek Exploring the requirement for the DEAD-box protein DDX5 in cancer cell proliferation Cdt2 132 Morris Thymine DNA glycosylase is a CRL4 substrate 133 Mueller Characterization of RPA-protein interactions and their dependence on the phospho-mimetic state of the N-terminus of Saccharomyces cerevisiae Rfa2 134 Müller Comparative genomics of chromosome replication 135 Muster Microirradiation—See DNA damage and repair in a new light 136 Nieduszynski Accelerated growth in the absence of DNA replication origins 137 Ning Physical interaction of SV40 T antigen with the checkpoint recruitment domain of human RPA facilitates viral DNA replication Page 6 of 11 138 Noguchi Maf1-dependent transcriptional inhibition of tRNA genes preserves genome integrity during DNA replication in response to nutrient stress 139 O'Donnell DNA twisting caused by coupled leading/lagging strand replisomes produces incomplete Okazaki fragments 140 Oelmezer Yen1 protects Dna2 helicase mutants from DNA replication stress 141 Oh PinX1 maintains telomere integrity by modulating TRF1 homeostasis, the process in which hTERT plays dual roles 142 Ohashi The positive feedback cycle of ATR-activation and TopBP1 accumulation triggered by interaction of Rad9-Hus1-Rad1 with TopBP1 143 Ortega Translation of maternal Orc2 mRNA may play a role in maintaining DNA replication origin sites in the zygote 144 Papadopoulou Replication stress-induced epigenetic instability 145 Piergiovanni Uncovering the role of GEMC1 in mammalian DNA replication and genome stability maintenance

146 Pillon Trapping intermediate steps in the DNA mismatch repair pathway 147 Pisani Physical and functional interactions of the human Tim and Tipin proteins at the replication fork

148 Prioleau The spatio-temporal program of DNA replication is driven by specific epigenetic signatures in human cells 149 Ragland RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells 150 Rainey Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint 151 Rankin The Cohesin interacting protein Pds5 mediates both pro- and anti-cohesion activities during cohesion establishment 152 Rapp Combined genome-wide and 3D super-resolution nanoscopy analysis of the DNA damage response 153 Rodriguez Early-firing replication origins in Saccharomyces cerevisiae show signs of histone imbalance 154 Sanuki Creating an artificial origin of replication in Xenopus egg extracts 155 Sato Delineating the contribution of DNA replication stress towards c-Myc-induced genomic instability

156 Schepers Principles of H4K20methylation in regulating origin activity 157 Schildkraut DNA replication fork progression through the fragile X and telomere repeats 158 Sedman DEAH-box protein Irc3 is required for yeast mitochondrial DNA maintenance 159 Sedman Replication intermediates in the yeast S. cerevisiae mitochondria 160 Segatto Leishmania spp. telomere measurement by quantitative PCR 161 Segura-Wang Genome-wide mutational landscape and mechanisms of spontaneous genomic variations in Saccharomyces cerevisiae

Page 7 of 11 162 Sequeira-Mendes Chromatin states define DNA replication origin classes in a live organism 163 Shimada TORC2 signaling pathway guarantees genome stability in face of strand breaks 164 Sima What determine replication timing? 165 Simon Image reconstruction of the S. cerevisiae Mcm2-7 complex 166 Singh Cdc23/Mcm10 primase cooperates with DNA Polα to generate the lagging strand-specific ribonucleotide imprint in fission yeast 167 Small IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs 168 Sowd ATM and ATR kinase activities orchestrate replication fork repair during SV40 chromatin replication 169 Sparks Role of RNase H2 and Topoisomerase 1 in ribonucleotide excision repair 170 St Charles Contributions of nucleotide selectivity, proofreading and mismatch repair to leading and lagging strand DNA replication fidelity in vivo 171 Stavnezer Off-target DSBs induced by AID during Ig class switch recombination are highly enriched in direct tandem repeats 172 Stewart Human CST promotes replication restart through new origin firing 173 Stodola Kinetic analysis of replication by yeast DNA polymerase δ 174 Suman Dbf4 and Cdc7 interact with mutually exclusive subunits of Mcm2-7 helicase 175 Szambowska Structural characterization and DNA-binding analysis of the human Cdc45 protein 176 Takahashi MutSα-dependent eviction of nucleosomes around mismatch sites in Xenopus egg extracts

177 Tanaka Dpb11/TopBP1–GINS interaction is required for efficient initiation of DNA replication 178 Thu Mcm10 deficiency triggers a Slx5/8-dependent SUMO-mediated DNA damage response 179 Ticau Single molecule studies of eukaryotic helicase loading 180 Tognetti Study of the protein-protein interactions involved in Cdc45 recruitment to the pre-replication complex 181 Tsai Genome-wide identification of replication-associated breakpoints by ATR inhibition 182 Tsurimoto Functions of the C-terminal of the chromosome cohesion PCNA loader, Ctf18-RFC 183 Valton A potential G-quadruplex motif is necessary for replication initiation in vertebrates 184 Vijayraghavan Mcm2-7 coordinates checkpoint control and sister chromatid cohesion with DNA replication 185 Vindigni Mechanistic insights into replication fork reversal and restart under genotoxic stress 186 Waga Preferential binding of human origin recognition complex to G-quadruplex-formable RNA and single-stranded DNA 187 Wang PDIP46—A novel activator of DNA polymerase δ activity 188 Wanrooij Common features of proteins that activate the Mec1 checkpoint kinase 189 Wei Functional analysis of sumoylation in DNA replication Page 8 of 11 190 Weinreich Analysis of Sir2-regulated origins genome-wide reveals an unexpected linkage to Ty element long terminal repeats 191 Wilson The role of the N-terminus of Rfa2 in double-strand break repair in budding yeast 192 Xu Fission yeast Cut5 mainly functions in the Chk1-mediated DNA damage checkpoint pathway as a scaffold protein 193 Yagura In vitro study of the initiation of chromosomal DNA replication in budding yeast Cdh1 194 Yamada ATR-Chk1-APC/C -dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress 195 Yang Rad18 functions in hematopoietic genome maintenance 196 You Characterization of crucial arginine residues on Cdt1 that affect licesing activity and interaction with Geminin or MCM complex 197 Young Histone ‘proteoforms’ before and after replication 198 Zhang BRCA1 down-regulates the kinase activity of polo-like kinase 1 in response to replication stress

Cdt2 199 Zhang CRL4 regulates DNA polymerase δ by targeting p12 for degradation in response to DNA damage and during the cell cycle progression 200 Zhang Architectures of key components in DNA damage signalling 201 Zhang Monoubiquitylation of Cdc45 and dynamic association with Mrc1 facilitate actions of Cdc45 on the chromatin 202 Zhao DNA sequence specificity of herpes virus origin binding protein 203 Zhou CTCF plays essential role in herpes simplex virus type I replication

Session 7 REPLISOME ACTIVITIES AND FUNCTIONS WEDNESDAY 9/11/2013, 7:30 PM L. Bloom / A. Donaldson # lname Title Talk Length 204 Bloom Clamp loader function and mechanism 12 205 Botchan The path of the leading and lagging strands bound to the helicase—GINS and Cdc45 are 12 guardians of the CMG 2/5 gate 206 Enemark Identification of a conserved single-stranded DNA binding element and its role in MCM helicase 12 loading and replication initiation 207 Johansson Structure of yeast DNA polymerase epsilon 12 208 Langston Identification and biochemical characterization of CMGE, a minimal eukaryotic leading strand 12 replisome 209 Donaldson Tel1 phosphorylates Rif1 and regulates telomere replication time 12 210 Paschini A telomere-dedicated RPA complex is essential for replication of duplex telomeric DNA 12 211 Lin Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two 12 forms of human DNA polymerase δ 212 Daigaku Novel insights into PCNA ubiquitylation during genomic replication 12 Page 9 of 11 213 Costanzo A dynamic interplay between the Mta2/NuRD complex and the replisome pausing complex is 12 required to preserve replication fork integrity

Session 8 DEALING WITH BLOCKS AND LESIONS THURSDAY 9/12/2013, 9:00 AM W. Yang / P. Burgers # lname Title Talk Length 214 Yang Translesion DNA synthesis in human 12 215 Burgers Translesion synthesis by Rev1 and a four-subunit DNA polymerase ζ complex 12 216 Doherty PrimPol, a novel mammalian polymerase involved in chromosomal DNA replication 12 217 Duxin Replication-coupled repair of a DNA-protein crosslink 12 218 Noguchi Warsaw breakage syndrome helicase ChlR1 is required for replication recovery from ICL DNA 12 damage 219 Castillo Bosch FANCJ prevents replication fork stalling by unwinding G4 structures during DNA replication 12 220 Borowiec Phosphorylated RPA recruits the PALB2 tumor suppressor to stalled DNA replication forks to 12 facilitate fork recovery 221 Moldovan A novel PCNA ubiquitination-dependent pathway that regulates DNA damage bypass by the 12 replication fork 222 Gottifredi UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic 12 stability 223 Zhao Multiple recombinational repair pathways facilitate replication under DNA damage conditions 12

Session 9 DEVELOPMENT, CELL CYCLE AND CANCER THURSDAY 9/12/2013, 2:00 PM B. Calvi / V. Gorgoulis # lname Title Talk Length 224 Calvi Endoreplication in development and cancer 12 225 Zegerman Titration of four replication initiation factors is essential for the mid-blastula transition of Xenopus 12 laevis 226 Murakami Recruitment of the cell cycle regulatory kinase DDK to replication forks temporally coordinates 12 replication with meiotic double-strand break formation 227 Ikui Stress-induced Cdc6 degradation is triggered by GSK3 kinase after Cdk1-dependent priming 12

228 Sansam The effects of deregulating replication initiation on S-phase progression 12 229 Gorgoulis The role of the replication licensing machinery in cancer 12 230 Mendez Control of origin activity in vivo—Mouse models for the overexpression of initiator proteins reveal a 12 functional cooperation between Cdc6 and Cdt1 231 Li Implicating cryptic rereplication in copy number expansions 12 232 Gilbert Replication timing control in development and cancer 12

Page 10 of 11 233 Lopes Replication fork reversal is a general response to replication stress in human cells 12

Session 10 REPLICATION STRESS AND DAMAGE SIGNALING FRIDAY 9/13/2013, 9:00 AM D. Cortez / J. Lukas # lname Title Talk Length 234 Cortez Function and regulation of the SMARCAL1 DNA-dependent ATPase in replication fork repair 12

235 Zou PRP19 links protein ubiquitylation to RPA-ssDNA and activation of the ATR checkpoint 12 236 Saxena An alternate single-strand binding protein complex recruits ATR-ATRIP complex to the sites of 12 DNA damage 237 Wu Regulation of the ATR checkpoint by a novel SUMO-mediated mechanism 12 238 Smolka Activator-specific modulation of Mec1 signaling during DNA replication 12 239 Lukas Spatial and temporal regulation of genome surveillance at replication fork 12 240 Brown Replication-associated breakpoints and mechanisms of fork collapse due to ATR-deficiency 12

241 Zhu The activation of Chk1 is dependent on an ATR-mediated functional link between And-1 and Claspin 12

242 Pfander A cell cycle regulated Dpb11-Slx4 complex controls the response to stalled replication forks 12 during S-phase 243 Alfano NONO regulates the intra-S phase checkpoint in response to UV radiation acting upstream of 12 Rad17, RAD9 and TopBP1

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