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The Work of the Theban Mapping Project by Kent Weeks Saturday, January 30, 2021
Virtual Lecture Transcript: Does the Past Have a Future? The Work of the Theban Mapping Project By Kent Weeks Saturday, January 30, 2021 David A. Anderson: Well, hello, everyone, and welcome to the third of our January public lecture series. I'm Dr. David Anderson, the vice president of the board of governors of ARCE, and I want to welcome you to a very special lecture today with Dr. Kent Weeks titled, Does the Past Have a Future: The Work of the Theban Mapping Project. This lecture is celebrating the work of the Theban Mapping Project as well as the launch of the new Theban Mapping Project website, www.thebanmappingproject.com. Before we introduce Dr. Weeks, for those of you who are new to ARCE, we are a private nonprofit organization whose mission is to support the research on all aspects of Egyptian history and culture, foster a broader knowledge about Egypt among the general public and to support American- Egyptian cultural ties. As a nonprofit, we rely on ARCE members to support our work, so I want to first give a special welcome to our ARCE members who are joining us today. If you are not already a member and are interested in becoming one, I invite you to visit our website arce.org and join online to learn more about the organization and the important work that all of our members are doing. We provide a suite of benefits to our members including private members-only lecture series. Our next members-only lecture is on February 6th at 1 p.m. -
Needle Roller and Cage Assemblies B-003〜022
*保持器付針状/B001-005_*保持器付針状/B001-005 11/05/24 20:31 ページ 1 Needle roller and cage assemblies B-003〜022 Needle roller and cage assemblies for connecting rod bearings B-023〜030 Drawn cup needle roller bearings B-031〜054 Machined-ring needle roller bearings B-055〜102 Needle Roller Bearings Machined-ring needle roller bearings, B-103〜120 BEARING TABLES separable Self-aligning needle roller bearings B-121〜126 Inner rings B-127〜144 Clearance-adjustable needle roller bearings B-145〜150 Complex bearings B-151〜172 Cam followers B-173〜217 Roller followers B-218〜240 Thrust roller bearings B-241〜260 Components Needle rollers / Snap rings / Seals B-261〜274 Linear bearings B-275〜294 One-way clutches B-295〜299 Bottom roller bearings for textile machinery Tension pulleys for textile machinery B-300〜308 *保持器付針状/B001-005_*保持器付針状/B001-005 11/05/24 20:31 ページ 2 B-2 *保持器付針状/B001-005_*保持器付針状/B001-005 11/05/24 20:31 ページ 3 Needle Roller and Cage Assemblies *保持器付針状/B001-005_*保持器付針状/B001-005 11/05/24 20:31 ページ 4 Needle roller and cage assemblies NTN Needle Roller and Cage Assemblies This needle roller and cage assembly is one of the or a housing as the direct raceway surface, without using basic components for the needle roller bearing of a inner ring and outer ring. construction wherein the needle rollers are fitted with a The needle rollers are guided by the cage more cage so as not to separate from each other. The use of precisely than the full complement roller type, hence this roller and cage assembly enables to design a enabling high speed running of bearing. -
Open Xiaofan Li Dissertation.Pdf
The Pennsylvania State University The Graduate School Eberly College of Science EVOLUTIONARY ORIGINS AND PIP2 MODULATION OF VOLTAGE-GATED K+ CHANNELS A Dissertation in Molecular, Cellular, and Integrative Biosciences by Xiaofan Li © 2015 Xiaofan Li Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy December 2015 ii The dissertation of Xiaofan Li was reviewed and approved* by the following: Timothy Jegla Assistant Professor of Biology Dissertation Advisor Chair of Dissertation Committee Bernhard Lüscher Professor of Biology Professor of Biochemistry and Molecular Biology Melissa Rolls Associate Professor of Biochemistry and Molecular Biology Chair of the Molecular, Cellular and Integrative Biosciences Graduate Program David Vandenbergh Associate Professor of Biobehavioral Health Associate Director of the Penn State Institute of the Neurosciences *Signatures are on file in the Graduate School iii Abstract Voltage-gated K+ channels are important regulators of neuronal excitability. Bilaterians have eight functionally distinct Voltage-gated K+ channel subfamilies: Shaker, Shab, Shaw, Shal, KCNQ, Eag, Erg and Elk. These subfamilies are defined by sequence conservation, functional properties as well as subfamily-specific assembly. Genome searches revealed metazoan-specificity of these gene families and the presence of prototypic voltage-gated K+ channels in a common ancestor of ctenophores (comb jellies) and parahoxozoans (bilaterians, cnidarians and placozoans). Establishment of the gene subfamilies, however happened later in a parahoxozoan ancestor. Analysis of voltage- gated K+ channels in a cnidarians species Nematostella vectensis (sea anemone) unveiled conservation in functional properties with bilaterian homologs. Phosphoinositide (most notably PIP2) regulation of ion channels is universal in eukaryotes. PIP2 modulates Shaker, KCNQ and Erg channels in distinct manners, while PIP2 regulation of Elk channels has not been reported. -
Protective Zika Vaccines Engineered to Eliminate Enhancement of Dengue Infection Via Immunodominance Switch
ARTICLES https://doi.org/10.1038/s41590-021-00966-6 Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch Lianpan Dai 1,2,3,8 ✉ , Kun Xu3,8, Jinhe Li2,4,8, Qingrui Huang5, Jian Song 1, Yuxuan Han2, Tianyi Zheng2,4, Ping Gao2,4, Xuancheng Lu6, Huabing Yang 5, Kefang Liu7, Qianfeng Xia3, Qihui Wang 1, Yan Chai1, Jianxun Qi 1, Jinghua Yan 5 ✉ and George F. Gao 1,2,4 ✉ Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related Zika virus (ZIKV) because vaccine may prime deleterious antibodies to enhance natural infections. Cross-reactive antibodies targeting the conserved fusion loop epitope (FLE) are known as the main sources of ADE. We design ZIKV immunogens engineered to change the FLE conformation but preserve neutralizing epitopes. Single vaccination conferred sterilizing immunity against ZIKV without ADE of DENV-serotype 1–4 infections and abrogated maternal–neonatal transmis- sion in mice. Unlike the wild-type-based vaccine inducing predominately cross-reactive ADE-prone antibodies, B cell profiling revealed that the engineered vaccines switched immunodominance to dispersed patterns without DENV enhancement. The crystal structure of the engineered immunogen showed the dimeric conformation of the envelope protein with FLE disruption. We provide vaccine candidates that will prevent both ZIKV infection and infection-/vaccination-induced DENV ADE. IKV is a mosquito-borne pathogen belonging to the genus models12,13,19,20. More importantly, a recent study of pediatric cohorts Flavivirus in the family Flaviviridae1. The 2015–2016 ZIKV in Nicaragua clearly shows that previous ZIKV infection enhanced epidemic spread to 84 countries worldwide, including future risk of DENV2 disease and severity, as well as DENV3 sever- Z2,3 21,22 China . -
Il Cristianesimo in Egitto Luci E Ombre in Abydos La Tomba
egittologia.net magazine in questo numero: IL CRISTIANESIMO IN EGITTO EGITTO A VENEZIA LUCI E OMBRE IN ABYDOS SPECIALE NEFERTARI LA TOMBA QV66 AREA ARCHEOLOGICA TEBANA IL VILLAGGIO DI DEIR EL-MEDINA EGITTO IN PILLOLE ISCRIZIONI IERATICHE NELLA TOMBA DI THUTMOSI IV Italiani in Egitto: Ernesto Schiaparelli | L’Arte di Shamira | I papiri di Carla BOLLETTINO INFORMATIVO DELL'ASSOCIAZIONE EGITTOLOGIA.NET NUMERO 3 e d i t o r i a l e La prolungata e precoce presenza di questo Confesso che questo numero di EM – Egitto- insolito e intenso caldo, dà l’impressione che logia.net Magazine è stato sul punto di non l’estate stia già volgendo al termine, anche se uscire! La prossimità con il ferragosto e il in realtà la legna accumulata per l’inverno caldo scoraggiante, soprattutto nelle due set- dovrà aspettare ancora molto tempo prima di timane centrali del mese di luglio – periodo in essere utile. cui il terzo numero del magazine ha comin- Curioso come hanno deciso di chiamare le tre ciato a prendere vita – ci avevano fatto propen- fasi più intense del caldo i meteorologici: Sci- dere per una sospensione, procrastinandone pione, Caronte e Minosse. Curioso perché mi l’uscita direttamente a ottobre. vien da pensare che l’epiteto “Africano” di Sci- Ma abbiamo resistito alla tentazione, sospen- pione e il collegamento con l’Ade che è possi- dendo solo una parte dei temi che abbiamo bile fare con Caronte e Minosse, abbia cominciato a trattare nei numeri precedenti, richiamato alla mente degli scienziati il con- come ci è stato richiesto dagli autori degli cetto di “caldo”. -
How to Plan an Unforgettable Journey in Egypt (Pdf
1 | P a g e How to Plan an Unforgettable Journey in EGYPT Kenn Laya Director North America – EGYPT Tourism USA – New York, New York CEO / Product Development – Vuitton Travel & Luxury Lifestyle – New York, New York Edited By Maria Koehmstedt Cover Photography & Design Charls Lamber Contributor / Ferskov Communications 2 | P a g e To all the people of Egypt, this e-book is for you. By writing "How to Plan an Unforgettable Journey in EGYPT", it is my hope that the many people who read this work come to realize just how amazing it is to visit your incredible country. May they come to see your bountiful sites for themselves and then send their friends. And when they are there, it is my hope that they meet as many of you as is possible during their journey so that when they return, like myself, they can proudly say "I have friends in Egypt." To all of you who I already know in Egypt, and to all of you I have yet to meet, forever you will remain in my heart, as my friends. 3 | P a g e An Egyptian Journey immerses travelers in more than 7,000 years of history – ancient Egypt to the Roman Empire, Islamic dynasties to modern metropolises. With vast and beautiful deserts, fresh oases, simple villages, chaotic metropolises, tranquil Red Sea resorts, the palm-lined Nile and awe- inspiring, sand-swathed monuments, there’s a place for all personalities of traveler. While the country comprises a mixture of different cultures and religions, a unifying and omnipresent sense of hospitality runs deep in the blood of every Egyptian – a warmness toward one another and a kind embrace to all who visit her. -
Modulation of Voltage-Gated K Channels by the Sodium Channel Β1
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit Hai M. Nguyena, Haruko Miyazakib, Naoto Hoshic, Brian J. Smithd, Nobuyuki Nukinab, Alan L. Goldine, and K. George Chandya,1 Departments of aPhysiology and Biophysics, cPharmacology, and eMicrobiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697; bLaboratory for Structural Neuropathology, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan; and dLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia Edited* by Michael D. Cahalan, University of California, Irvine, CA, and approved September 26, 2012 (received for review June 1, 2012) β – Voltage-gated sodium (NaV) and potassium (KV) channels are critical Here, we examined whether the NaV 1 KV4.x interaction was components of neuronal action potential generation and propaga- specific for this family of KV channels, or whether NaVβ1 could β SCN1b tion. Here, we report that NaV 1 encoded by , an integral interact and modulate the functions of other families of KV chan- subunit of NaV channels, coassembles with and modulates the bio- nels in mammals. We selected three families of KV channels (KV1, physical properties of KV1andKV7 channels, but not KV3 channels, in KV3, and KV7) for these studies. We report that NaVβ1modulates fi β an isoform-speci c manner. Distinct domains of NaV 1 are involved the function of KV1.1, KV1.2, KV1.3, KV1.6, and KV7.2 channels, in modulation of the different KV channels. Studies with channel but not KV3.1 channels, in an isoform-specific manner. Through chimeras demonstrate that NaVβ1-mediated changes in activation the use of chimeric and mutational strategies we identified regions kinetics and voltage dependence of activation require interaction in NaVβ1 and KV channels required for channel modulation, and of NaVβ1 with the channel’s voltage-sensing domain, whereas docking simulations suggest a molecular model of the interaction of changes in inactivation and deactivation require interaction with the two proteins. -
DSFRA IKEN Report Template
APPENDIX A TO REPORT CSCPC/19/2 DATA TABLES Urban Area: Five-Year Averages – 01/04/2014 to 31/04/2019 Incidents on station grounds Location False Pump Attendances Overview Fires Special Service Alarm All incidents All incidents Special All by On own On own Station Primary: False Station Name Community five-year excluding Co-responder All Primary Secondary Service RTC Flooding station's station station Number Dwelling Alarms average co-responder Calls pumps ground ground (%) Greenbank KV50 Urban Area 878.6 878.6 0 245 104.6 56.6 140.4 361.4 271.8 21.6 24.6 1424.8 974.2 68.4% Danes Castle KV32 Urban Area 832.6 830.8 1.8 198.8 126.4 56.6 72.4 385 248.4 29.2 14.8 1090.6 849.4 77.9% Torquay KV17 Urban Area 744.8 744.8 0 207.8 111 59 96.8 306.8 230 36 15.8 919.8 776.4 84.4% Crownhill KV49 Urban Area 742 741.8 0.2 227 100.6 43 126.4 337.4 177.4 28.6 9 878.4 680.6 77.5% Taunton KV61 Urban Area 734 733.4 0.6 227.8 132.8 56.6 95 284.6 221.6 65.4 8.4 1038.8 901.8 86.8% Bridgwater KV62 Urban Area 584.2 577.6 6.6 160 88.2 38 71.8 231.8 192.4 56 8 774.4 666 86.0% Middlemoor KV59 Urban Area 537.6 535.8 1.8 144.2 91.2 33 53 239.6 153.8 51 8.8 724.4 444 61.3% Camels Head KV48 Urban Area 491.6 491.2 0.4 162.8 85.2 50.4 77.6 178.6 150.2 16.6 11.8 638 390.2 61.2% Yeovil KV73 Urban Area 471.6 471.6 0 139.6 78.6 34.8 61 191 141 46.8 7.4 674.2 569 84.4% Plympton KV47 Urban Area 218.4 204.4 14 57.8 34.8 12 23 87.8 72.4 18.6 3 170.6 135.8 79.6% Plymstock KV51 Urban Area 185.8 185 0.8 48.4 27.4 12 21 76.8 60.6 12.6 2.6 165.4 123.8 74.8% Urban Area: Incidents on -
International Kv7 Channels Symposium 2019
ABSTRACT BOOK International Kv7 Channels Symposium 2019 INTERNATIONAL Kv7 CHANNELS SYMPOSIUM 12 - 14 September 2019 Naples · Italy www.kv7channels2019naples.org WELCOME Index Oral Abstracts . 21 Poster Abstracts . 71 INFORMATION PROGRAMME INDUSTRY ABSTRACTS 3 WELCOME INFORMATION 21 PROGRAMME Oral Abstracts Oral INDUSTRY ABSTRACTS KEYNOTE SPEAKER [O1] NEURONAL KV7 M-CHANNELS: PROPERTIES AND REGULATION David Brown1 1University College London, Neuroscience, Physiology & Pharmacology, London, United Kingdom I joined the band of future Kv7 afficionados 40 years ago, when we discovered the M-current in bullfrog sympathetic neurons (Brown & Adams, 1979: Soc. Neurosci. Abstr. 5:585; 1980:Nature, 283;673). This was seen as a voltage-de- pendent, subthreshold, non-inactivating potassium current that had a dramatic braking action on repetitive action potential discharges. It was dubbed “M-current” because it was inhibited by muscarine, acting on muscarinic ace- tylcholine receptors (mAChRs), thereby increasing action potential discharges. M-current is an imperfect descriptor because the current can also be inhibited by activating other Gq-type G protein-coupled receptors (GPCRs) and mus- carine itself only works if the cell has M1, M3 or M5 receptors, not M2 or M4 (Robbins et al., 1991: Eur J Neurosci. 3: 820). The molecular composition of the M-channel was revealed some two decades later by David McKinnon and his colleagues as a combination of theKCNQ2 and KCNQ3 gene products Kv7.2 and Kv7.3 (Wang et al., 1998: Science. 282: 1890), probably as a 2+2 heteromer (Hadley et al, 2003: J Neurosci. 23: 5012). Though gated by voltage, the channels require the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP2) to open (Zhanget al., 2003: Neuron. -
Geochemistry and Transport of Uranium- Bearing Dust at Jackpile Mine, Laguna, New Mexico
Geochemistry and Transport of Uranium- Bearing Dust at Jackpile Mine, Laguna, New Mexico By Reid Douglas Brown Submitted in Partial Fulfillment of the Requirements for the Masters of Science in Hydrology New Mexico Institute of Mining and Technology Department of Mechanical Engineering Socorro, New Mexico (August 2017) ABSTRACT Closed mines pose significant risks to the environment and human health. Uranium mine contamination of surface water, groundwater and soil have received moderate attention, but few studies have investigated dust transport of uranium. The latter has immediate implications for remediation efforts and environmental/human health regulators. Frequent dust storms intensify aeolian transport of uranium in arid settings. At the Jackpile Mine in Laguna Pueblo, New Mexico, 15 sets of dust traps have been installed at heights of 0.25 m, 0.5 m, 1.0 m and 1.5 m above the soil surface. Some of these traps are within the mine pit, while others are up to 4 km away; dust from these sites was collected every two months. In addition, soil samples from each site were collected and sieved into eight size classes. All samples were acid digested, and the uranium content analyzed using Inductively Coupled Plasma Mass Spectrometry. We investigate whether uranium has an affinity for a particular particle size class, with interest centered on particles small enough to be completely inhaled by humans. Results show that surface concentrations of uranium vary substantially across the landscape. Distance from the pit shows no correlation with uranium in the upper 5 cm of soil. Other factors appear to control accumulation, such as vegetation height and density and topographic relief, which are known to have a significant impact on wind speeds, soil erosion and dust deposition. -
Multistate Structural Modeling and Voltage-Clamp Analysis of Epilepsy/Autism Mutation Kv10.2–R327H Demonstrate the Role Of
16586 • The Journal of Neuroscience, October 16, 2013 • 33(42):16586–16593 Neurobiology of Disease Multistate Structural Modeling and Voltage-Clamp Analysis of Epilepsy/Autism Mutation Kv10.2–R327H Demonstrate the Role of This Residue in Stabilizing the Channel Closed State Yang Yang,1,2,3* Dmytro V. Vasylyev,1,2,3* Fadia Dib-Hajj,1,2,3 Krishna R. Veeramah,4 Michael F. Hammer,4 Sulayman D. Dib-Hajj,1,2,3 and Stephen G. Waxman1,2,3 1Department of Neurology and 2Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, 3Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, and 4Arizona Research Laboratories Division of Biotechnology, University of Arizona, Tucson, Arizona 85721 Voltage-gated potassium channel Kv10.2 (KCNH5) is expressed in the nervous system, but its functions and involvement in human disease are poorly understood. We studied a human Kv10.2 channel mutation (R327H) recently identified in a child with epileptic encephalopathy and autistic features. Using multistate structural modeling, we demonstrate that the Arg327 residue in the S4 helix of voltage-sensingdomainhasstrongionicinteractionswithnegativelychargedresidueswithintheS1–S3helicesintheresting(closed)and early-activation state but not in the late-activation and fully-activated (open) state. The R327H mutation weakens ionic interactions between residue 327 and these negatively charged residues, thus favoring channel opening. Voltage-clamp analysis showed a strong hyperpolarizing(ϳ70mV)shiftofvoltagedependenceofactivationandanaccelerationofactivation.Ourresultsdemonstratethecritical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease. -
OPG 1994 INIS-Mf—14550 WWAW
/1r/Tflso?Y" A^f^011 •• OPG 1994 INIS-mf—14550 WWAW Jahrestagung Österreichische Physikalische Gesellschaft 19.-23. September Universität Innsbruck WWA W Ehrenschutz Dr. Erhard Busek Vizekanzler Bundesminister für Wissenschaft und Forschung Dr. Wendelin Weingartner Landeshauptmann von Tirol DDr. Herwig Van Staa Bürgermeister der Stadt Innsbruck Prof. Dr. Hans Mos?r Rektor der Universität Innsbruck Osterreichische Physikalische Gesellschaft 44. Jahrestagung 19.-23. September 1994 Universität Innsbruck Tagungsprogramm Organisationskomitee Andrea Aglibut Ralph Höpfel Dietmar Kuhn Norbert Nessler Christine Obmascher Jörg Schmiedmayer Walter Seidenbusch Michael Weber Harald Weinfurter Anton Zeilinger Die Veranstaltung der ÖPG-Jahrestagung 1994 wird gefördert von: Bundesministerium fur Wissenschaft und Forschung Bundesministerium für Unterricht und Kunst Land Tirol Landeshauptstadt Innsbruck Universität Innsbruck Herausgeber und Medieninhaber: Österreichische Physikalische Gesellschaft Layout & Graphik: Michael Weber £MCMXCIV "Qkologie und Ökonomie schließen sich nicht länger aus." T i r o I e r S Sparkasse > Inhalt Hinweise fur Tagungsteilnehmer 7 Lageplan der Universität Innsbruck 13 Programmübersicht 17 Vorträge Haupttagung 27 Postersitzungen 37 Vorträge der Fachtagungen I IS Akustik IIS • Atom-,Molekül- und Plasmaphysik I2S Festkörperphysik 142 • Kern- und Teilchenphysik 147 Lehrkräfte an Höheren Schulen und Lehrerfortbildi/iig I /1 Medizinische Physik, Biophysik und Umweltphysik 173 Polymerphysik 183 • Quantenelektronik, Elektrodynamik