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Osteoporosis India Drug Forecast and Market Analysis to 2022

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Osteoporosis India Drug Forecast and Market Analysis to 2022 Osteoporosis India Drug Forecast and Market Analysis to 2022 Reference Code: GDHC1054CFR Publication Date: February 2013 Executive Summary Sales for Osteoporosis in India The figure below illustrates the osteoporosis sales by drug class in India during the forecast period. The Indian osteoporosis drug market was valued at approximately $437m in 2012, and is forecast to recede Sales for Osteoporosis Drugs in India by Drug Class, 2012–2022 to $433m at a negative CAGR of 0.1% by 2022 . 2% 2012 Major drivers of market growth over this forecast period Total: $437m 20% will include: Bisphosphonates Increased investment in healthcare and facility 43% SERMs accessibility nationwide (rural and urban) PTH Strontium Calcitonin Major barriers to the growth of the osteoporosis market will include: 31% 4% Loose IP laws and guidelines 2022 3% Total: $433m 17% Price-cutting practices Bisphosphonates 42% SERMs PTH Strontium Calcitonin 35% 3% Source: GlobalData © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. Page 2 GDHC1054CFR / Published FEB 2013 Executive Summary What Do the Physicians Think? “The NOG guidelines that are in place in the UK and that are being implemented for harmonization throughout “[The] [b]iggest need right now is that patients just don’t Europe gives you a differing percentage based upon the want to take our drugs. And we live in this environment age of the individual, so that younger people get treated that’s just becoming increasingly poisonous as far as at lower 10-year risk and older people get treated at patient perception [is concerned]. I think the WHO has higher 10-year risk.” done a fairly nice job with the FRAX calculator. Is it perfect? No. You still need clinical judgment, but that’s Key opinion leader, September 2012 what doctors are doing. We need some way to convey “The parathyroid hormone will only be used, or it should risk as well.” be used, in the population once the patent has expired, Key opinion leader, September 2012 and demosumab will have an important part of the market over the next five years, unless [reimbursement] “We are in dire need of new medications, and more limitations are put in some countries.” anabolic therapies have just immense potential. If you have a bone anabolic agent that doesn’t carry the black Key opinion leader, September 2012 box warning of osteosarcoma, that would be a really good thing.” Key opinion leader, September 2012 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. Page 3 GDHC1054CFR / Published FEB 2013 Table of Contents 1 Table of Contents 1 Table of Contents ............................................................................................................... 4 1.1 List of Tables ............................................................................................................... 7 1.2 List of Figures ............................................................................................................. 9 2 Introduction ....................................................................................................................... 10 2.1 Catalyst ..................................................................................................................... 10 2.2 Related Reports ........................................................................................................ 10 2.3 Upcoming Related Reports ........................................................................................ 12 3 Disease Overview ............................................................................................................. 13 3.1 Etiology and Pathophysiology .................................................................................... 13 3.1.1 Etiology ............................................................................................................... 13 3.1.2 Pathophysiology.................................................................................................. 16 3.1.3 Risk Factors ........................................................................................................ 17 3.1.4 Quality of Life ...................................................................................................... 17 3.2 Symptoms ................................................................................................................. 18 4 Disease Management ....................................................................................................... 19 4.1 Treatment Overview .................................................................................................. 19 4.1.1 Diagnosis and Referral ........................................................................................ 19 4.1.2 Treatment Guidelines .......................................................................................... 20 4.1.3 Disease Management ......................................................................................... 21 4.2 India .......................................................................................................................... 25 4.2.1 Diagnosis ............................................................................................................ 25 4.2.2 Clinical Practice .................................................................................................. 25 5 Competitive Assessment ................................................................................................... 26 5.1 Overview ................................................................................................................... 26 5.2 Strategic Competitor Assessment .............................................................................. 26 5.3 Product Profiles – Major Brands ................................................................................ 30 5.3.1 Actonel (risedronate sodium) ............................................................................... 30 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. Page 4 GDHC1054CFR / Published FEB 2013 Table of Contents 5.3.2 Evista (raloxifene hydrochloride) ......................................................................... 33 5.3.3 Reclast (zolendronic acid) ................................................................................... 36 5.3.4 Forteo (teriparatide) ............................................................................................ 40 5.3.5 Prolia (denosumab) ............................................................................................. 44 5.3.6 Protelos (strontium ranelate) ............................................................................... 47 5.3.7 Miacalcin and Fortical (calcitonin-salmon) ........................................................... 50 5.3.8 Viviant/Conbriza (bazedoxifene) .......................................................................... 54 5.3.9 Recalbon/Bonoteo (minodronic acid hydrate) ...................................................... 56 5.3.10 Alendronate sodium ............................................................................................ 59 5.3.11 Ibandronate......................................................................................................... 60 6 Opportunity and Unmet Need ............................................................................................ 62 6.1 Overview ................................................................................................................... 62 6.2 Unmet Needs ............................................................................................................ 62 6.2.1 Disease Awareness and Early Diagnosis............................................................. 63 6.2.2 Patient Compliance ............................................................................................. 63 6.2.3 Efficacy ............................................................................................................... 64 6.2.4 Safety ................................................................................................................. 65 6.2.5 Treatment Cost ................................................................................................... 66 6.2.6 Earlier Intervention .............................................................................................. 66 6.3 Unmet Needs Gap Analysis ....................................................................................... 67 6.4 Opportunity 1: Dual-Action Therapies ........................................................................ 69 6.5 Opportunity 2: Osteoporosis Prevention Therapies .................................................... 70 6.6 Opportunity 3: Dosing and Administration .................................................................. 71 7 Pipeline Assessment......................................................................................................... 72 7.1 Overview ................................................................................................................... 72 7.2 Promising Drugs in Clinical Development .................................................................. 73 7.2.1 Aprela (bazedoxifene and conjugated estrogens) ................................................ 74 7.2.2 Romosozumab (AMG-785).................................................................................
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