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2012 Portfolio Analysis Projects: Question 2: How Can I Understand 2012 Portfolio Analysis Projects Please note that data are not yet final; additional projects may be added. QUESTION 2: HOW CAN I UNDERSTAND WHAT IS HAPPENING? 2.S.A Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.) Principal Project Title Institution Funding Funder Investigator Systematic characterization of the Alaedini, Weill Cornell Medical $0.00 Department immune response to gluten and Armin College of Defense casein in autism spectrum disorders Autoimmunity against novel antigens Balice- University of $320,000. National in neuropsychiatric dysfunction Gordon, Pennsylvania 00 Institutes of Rita Health Convergence of immune and genetic Barrow, University of $0.00 Brain & signaling pathways in autism and Stephanie California, Davis Behavior schizophrenia Research Foundation Altered placental tryptophan Bonnin, University of $535,699. Department metabolism: A crucial molecular Alexandre Southern California 00 of Defense pathway for the fetal programming of neurodevelopmental disorders Brain mitochondrial abnormalities in Chauhan, New York State $20,000.0 Autism autism Abha Institute for Basic 0 Research Research in Institute Developmental Disabilities Mechanisms of synaptic alterations in Dunaevsky University of $579,882. Department a neuroinflammation model of autism , Anna Nebraska Medical 00 of Defense - Center Autism Research Program This document is for discussion purposes only and does not reflect the decisions of the IACC IL-1beta and IL1RAPL1: Gene- Estes, University of $28,600.0 Autism environment interactions regulating Myka California, Davis 0 Speaks synapse density and function in ASD Redox abnormalities as a vulnerability Hepel, State University of $0.00 Department phenotype for autism and related Maria New York at of Defense alterations in CNS development Potsdam Sensitive periods in cerebellar Hoffman, University of $32,941.0 National development Jessica Maryland, Baltimore 0 Institutes of Health Hyperthermia and the amelioration of Hollander, Montefiore Medical $66,153.0 Simons autism symptoms Eric Center 0 Foundation Exploring metabolic dysfunction in the Hu, Valerie George Washington $0.00 Simons brains of people with autism University Foundation Redox abnormalities as a vulnerability James, Arkansas Children's $0.00 Department phenotype for autism and related Sandra Hospital Research of Defense alterations in CNS development Institute Autism spectrum disorders – Jyonouchi, University of $30,000.0 Autism inflammatory subtype: Molecular Harumi Medicine & Dentistry 0 Research characterization of New Jersey Institute The Study of Toddlers with Autism Loh, Alvin Surrey Place Centre, $0.00 Health and Regression (STAR) Protocol – Toronto Resources Screening for treatable disorders and and Services biomarkers of inflammation and Administratio immune activation in the plasma and n CNS Prostaglandins and cerebellum McCarthy, University of $371,250. National development Margaret Maryland, Baltimore 00 Institutes of Health This document is for discussion purposes only and does not reflect the decisions of the IACC Redox abnormalities as a Noble, Mark University of $0.00 Department vulnerability phenotype for autism Rochester of Defense and related alterations in CNS development GABRB3 and placental vulnerability Palmer, Stanford University $642,258. National in ASD Theo 00 Institutes of Health GABA(A) and prenatal immune Palmer, Stanford University $125,000. Simons events leading to autism Theo 00 Foundation A non-human primate autism model Patterson, California Institute of $0.00 Simons based on maternal infection Paul Technology Foundation The mechanism of the maternal Patterson, California Institute of $150,000. Autism infection risk factor for autism Paul Technology 00 Speaks Influence of maternal cytokines Ponzio, University of $0.00 Autism during pregnancy on effector and Nicholas Medicine & Dentistry Speaks regulatory T helper cells as of New Jersey etiological factors in autism To study the relationship between Russo, A.J. Hartwick College $7,260.00 Autism low GAD2 levels and anti-GAD Research antibodies in autistic children Institute Mechanisms of mitochondrial Shoffner, Georgia State $0.00 Department dysfunction in autism John University of Defense Role of microglial activation in the Takei, Nori Hamamatsu $50,000.0 Brain and serotonergic and neuroimmune University School of 0 Behavior disturbances underlying autism Medicine Research Foundation Project 2: Immunological Van de University of $30,784.0 National susceptibility of autism (supplement) Water, Judy California, Davis 0 Institutes of This document is for discussion purposes only and does not reflect the decisions of the IACC Health 2.S.B Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years. Principal Project Title Institution Funding Funder Investigator Behavioral and cognitive Frazier, Cleveland Clinic $60,000.0 Simons characteristics of females and males Thomas Foundation 0 Foundation with autism ACE Network: Multimodal Pelphrey, Yale University $3,118,98 National developmental neurogenetics of Kevin 5.00 Institutes of females with ASD Health Why are autistic females rare and Turner, Johns Hopkins $28,600.0 Autism severe? An approach to autism gene Tychele University 0 Speaks identification. A sex-specific dissection of autism Weiss, University of $150,000. National genetics Lauren California, San 00 Institutes of Francisco Health Investigation of sex differences Werling, University of $32,413.0 National associated with autism candidate Donna California, Los 0 Institutes of gene, Cyfip1 Angeles Health 2.S.C Identify ways to increase awareness among the autism spectrum community of the potential value of brain and tissue donation to further basic research by 2011. IACC Recommended Budget: $1,400,000 over 2 years Principal Project Title Institution Funding Funder Investigator Building awareness of the value of Singer, Autism Science $90,120.0 Simons brain tissue donation for autism Alison Foundation 0 Foundation research This document is for discussion purposes only and does not reflect the decisions of the IACC 2.S.D Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years. Principal Project Title Institution Funding Funder Investigator Language development in fragile X Abbeduto, University of $584,381. National syndrome Leonard California, Davis 00 Institutes of Health Neurobiological mechanism of Anderson, Beth Israel $380,625. National 15q11-13 duplication autism spectrum Matthew Deaconess Medical 00 Institutes of disorder Center Health In-vivo imaging of neuronal structure Ash, Ryan Baylor College of $0.00 Autism and function in a reversible mouse Medicine Speaks model for autism. Beaudet, Baylor College of $60,000.0 Autism TMLHE deficiency and a carnitine Arthur Medicine 0 Speaks hypothesis for autism Role of Sema7A in functional Benson, Mount Sinai School $423,750. National organization of neocortex Deanna of Medicine 00 Institutes of Health Autism phenotypes in Tuberous Bolton, King's College $149,881. Autism Sclerosis: Risk factors, features & Patrick London 00 Speaks architecture Genetic and developmental analyses Broadie, Vanderbilt University $438,391. National of fragile X mental retardation protein Kendal Medical Center 00 Institutes of Health Abnormal network dynamics and Buonoman University of $192,500. National "learning" in neural circuits from o, Dean California, Los 00 Institutes of Fmr1-/- mice Angeles Health Functional circuit disorders of sensory Carlson, University of $254,976. National cortex in ASD and RTT Gregory Pennsylvania 00 Institutes of Health Neural mechanisms underlying autism Catterall, University of $94,903.0 Simons behaviors in SCN1A mutant mice William Washington 0 Foundation Nav1.1 channels, neural circuits, and Catterall, University of $10,213.0 Simons autism William Washington 0 Foundation This document is for discussion purposes only and does not reflect the decisions of the IACC Regulation of cortical critical periods in Contractor, Northwestern $60,000.0 Simons a mouse model of autism Anis University 0 Foundation Elucidation and rescue of amygdala Corbin, George Washington $150,000. Autism abnormalities in the Fmr1 mutant Joshua University 00 Speaks mouse model of fragile X syndrome Synaptic phenotype, development, Cox, University of Illinois $395,134. National and plasticity in the fragile X mouse Charles at Urbana 00 Institutes of Champaign Health The functional link between DISC1 DiDonato, Children's Memorial $0.00 Department and neuroligins: Two genetic factors Christine Hospital, Chicago of Defense in the etiology of autism Allelic choice in Rett syndrome Donohoe, Winifred Masterson $390,481. National Mary Burke Medical 00 Institutes of Research Institute Health Mechanisms of motor skill learning in Dunaevsky, University of $308,138. National the fragile X mouse model Anna Nebraska Medical 00 Institutes of Center Health Predicting
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