2012 Portfolio Analysis Projects
Please note that data are not yet final; additional projects may be added.
QUESTION 2: HOW CAN I UNDERSTAND WHAT IS HAPPENING? 2.S.A Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.) Principal Project Title Institution Funding Funder Investigator Systematic characterization of the Alaedini, Weill Cornell Medical $0.00 Department immune response to gluten and Armin College of Defense casein in autism spectrum disorders
Autoimmunity against novel antigens Balice- University of $320,000. National in neuropsychiatric dysfunction Gordon, Pennsylvania 00 Institutes of Rita Health
Convergence of immune and genetic Barrow, University of $0.00 Brain & signaling pathways in autism and Stephanie California, Davis Behavior schizophrenia Research Foundation
Altered placental tryptophan Bonnin, University of $535,699. Department metabolism: A crucial molecular Alexandre Southern California 00 of Defense pathway for the fetal programming of neurodevelopmental disorders
Brain mitochondrial abnormalities in Chauhan, New York State $20,000.0 Autism autism Abha Institute for Basic 0 Research Research in Institute Developmental Disabilities
Mechanisms of synaptic alterations in Dunaevsky University of $579,882. Department a neuroinflammation model of autism , Anna Nebraska Medical 00 of Defense - Center Autism Research Program
This document is for discussion purposes only and does not reflect the decisions of the IACC IL-1beta and IL1RAPL1: Gene- Estes, University of $28,600.0 Autism environment interactions regulating Myka California, Davis 0 Speaks synapse density and function in ASD
Redox abnormalities as a vulnerability Hepel, State University of $0.00 Department phenotype for autism and related Maria New York at of Defense
alterations in CNS development Potsdam
Sensitive periods in cerebellar Hoffman, University of $32,941.0 National development Jessica Maryland, Baltimore 0 Institutes of Health
Hyperthermia and the amelioration of Hollander, Montefiore Medical $66,153.0 Simons autism symptoms Eric Center 0 Foundation
Exploring metabolic dysfunction in the Hu, Valerie George Washington $0.00 Simons brains of people with autism University Foundation
Redox abnormalities as a vulnerability James, Arkansas Children's $0.00 Department phenotype for autism and related Sandra Hospital Research of Defense
alterations in CNS development Institute
Autism spectrum disorders – Jyonouchi, University of $30,000.0 Autism inflammatory subtype: Molecular Harumi Medicine & Dentistry 0 Research characterization of New Jersey Institute
The Study of Toddlers with Autism Loh, Alvin Surrey Place Centre, $0.00 Health and Regression (STAR) Protocol – Toronto Resources Screening for treatable disorders and and Services biomarkers of inflammation and Administratio immune activation in the plasma and n CNS
Prostaglandins and cerebellum McCarthy, University of $371,250. National
development Margaret Maryland, Baltimore 00 Institutes of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC Redox abnormalities as a Noble, Mark University of $0.00 Department vulnerability phenotype for autism Rochester of Defense and related alterations in CNS development
GABRB3 and placental vulnerability Palmer, Stanford University $642,258. National in ASD Theo 00 Institutes of Health
GABA(A) and prenatal immune Palmer, Stanford University $125,000. Simons events leading to autism Theo 00 Foundation
A non-human primate autism model Patterson, California Institute of $0.00 Simons based on maternal infection Paul Technology Foundation
The mechanism of the maternal Patterson, California Institute of $150,000. Autism infection risk factor for autism Paul Technology 00 Speaks
Influence of maternal cytokines Ponzio, University of $0.00 Autism during pregnancy on effector and Nicholas Medicine & Dentistry Speaks regulatory T helper cells as of New Jersey
etiological factors in autism
To study the relationship between Russo, A.J. Hartwick College $7,260.00 Autism low GAD2 levels and anti-GAD Research antibodies in autistic children Institute
Mechanisms of mitochondrial Shoffner, Georgia State $0.00 Department
dysfunction in autism John University of Defense
Role of microglial activation in the Takei, Nori Hamamatsu $50,000.0 Brain and serotonergic and neuroimmune University School of 0 Behavior disturbances underlying autism Medicine Research Foundation
Project 2: Immunological Van de University of $30,784.0 National susceptibility of autism (supplement) Water, Judy California, Davis 0 Institutes of
This document is for discussion purposes only and does not reflect the decisions of the IACC
Health
2.S.B
Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years. Principal Project Title Institution Funding Funder Investigator Behavioral and cognitive Frazier, Cleveland Clinic $60,000.0 Simons characteristics of females and males Thomas Foundation 0 Foundation with autism
ACE Network: Multimodal Pelphrey, Yale University $3,118,98 National developmental neurogenetics of Kevin 5.00 Institutes of females with ASD Health
Why are autistic females rare and Turner, Johns Hopkins $28,600.0 Autism severe? An approach to autism gene Tychele University 0 Speaks identification.
A sex-specific dissection of autism Weiss, University of $150,000. National
genetics Lauren California, San 00 Institutes of Francisco Health
Investigation of sex differences Werling, University of $32,413.0 National associated with autism candidate Donna California, Los 0 Institutes of gene, Cyfip1 Angeles Health
2.S.C
Identify ways to increase awareness among the autism spectrum community of the potential value of brain and tissue donation to further basic research by 2011. IACC Recommended Budget: $1,400,000 over 2 years Principal Project Title Institution Funding Funder Investigator Building awareness of the value of Singer, Autism Science $90,120.0 Simons brain tissue donation for autism Alison Foundation 0 Foundation research
This document is for discussion purposes only and does not reflect the decisions of the IACC
2.S.D
Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years. Principal Project Title Institution Funding Funder Investigator
Language development in fragile X Abbeduto, University of $584,381. National syndrome Leonard California, Davis 00 Institutes of Health
Neurobiological mechanism of Anderson, Beth Israel $380,625. National 15q11-13 duplication autism spectrum Matthew Deaconess Medical 00 Institutes of disorder Center Health
In-vivo imaging of neuronal structure Ash, Ryan Baylor College of $0.00 Autism and function in a reversible mouse Medicine Speaks
model for autism.
Beaudet, Baylor College of $60,000.0 Autism TMLHE deficiency and a carnitine Arthur Medicine 0 Speaks hypothesis for autism
Role of Sema7A in functional Benson, Mount Sinai School $423,750. National organization of neocortex Deanna of Medicine 00 Institutes of Health
Autism phenotypes in Tuberous Bolton, King's College $149,881. Autism Sclerosis: Risk factors, features & Patrick London 00 Speaks architecture
Genetic and developmental analyses Broadie, Vanderbilt University $438,391. National of fragile X mental retardation protein Kendal Medical Center 00 Institutes of Health
Abnormal network dynamics and Buonoman University of $192,500. National "learning" in neural circuits from o, Dean California, Los 00 Institutes of Fmr1-/- mice Angeles Health
Functional circuit disorders of sensory Carlson, University of $254,976. National
cortex in ASD and RTT Gregory Pennsylvania 00 Institutes of Health
Neural mechanisms underlying autism Catterall, University of $94,903.0 Simons behaviors in SCN1A mutant mice William Washington 0 Foundation
Nav1.1 channels, neural circuits, and Catterall, University of $10,213.0 Simons autism William Washington 0 Foundation
This document is for discussion purposes only and does not reflect the decisions of the IACC
Regulation of cortical critical periods in Contractor, Northwestern $60,000.0 Simons a mouse model of autism Anis University 0 Foundation
Elucidation and rescue of amygdala Corbin, George Washington $150,000. Autism abnormalities in the Fmr1 mutant Joshua University 00 Speaks
mouse model of fragile X syndrome
Synaptic phenotype, development, Cox, University of Illinois $395,134. National
and plasticity in the fragile X mouse Charles at Urbana 00 Institutes of Champaign Health
The functional link between DISC1 DiDonato, Children's Memorial $0.00 Department and neuroligins: Two genetic factors Christine Hospital, Chicago of Defense in the etiology of autism
Allelic choice in Rett syndrome Donohoe, Winifred Masterson $390,481. National Mary Burke Medical 00 Institutes of Research Institute Health
Mechanisms of motor skill learning in Dunaevsky, University of $308,138. National the fragile X mouse model Anna Nebraska Medical 00 Institutes of Center Health
Predicting phenotypic trajectories in Dykens, Vanderbilt University $310,752. National Prader-Willi syndrome Elisabeth Medical Center 00 Institutes of Health
Activity-dependent phosphorylation Ebert, Harvard Medical $177,055. National
of MeCP2 Daniel School 00 Institutes of Health
Pleiotropic roles of dyslexia genes in Eicher, Yale University $42,232.0 National neurodevelopmental language John 0 Institutes of impairments Health
Probing synaptic receptor Fagiolini, Boston Children's $124,998. Simons composition in mouse models of Michela Hospital 00 Foundation autism
Probing the neural basis of social Feng, Massachusetts $62,500.0 Simons behavior in mice Guoping Institute of 0 Foundation Technology
BDNF and the restoration of spine Gall, University of $470,063. National plasticity with autism spectrum Christine California, Irvine 00 Institutes of
disorders Health
The microRNA pathway in Gao, Fen- University of $352,647. National translational regulation of neurona Biao Massachusetts 00 Institutes of This document is for discussion purposes only and does not reflect the decisions of the IACC
development Medical School Health Cortical circuit changes and Gibson, Jay University of Texas $278,656. National mechanisms in a mouse model of Southwestern 00 Institutes of fragile X syndrome Medical Center Health Multigenic basis for autism linked to Goldfarb, Hunter College of $125,000. Simons 22q13 chromosomal region Mitchell the City University of 00 Foundation New York (CUNY) jointly with Research Foundation of CUNY
The role of UBE3A in autism Greenberg, Harvard Medical $312,501. Simons Michael School 00 Foundation
Genotype-phenotype relationships in Hagerman, University of $612,413. National fragile X families Randi California, Davis 00 Institutes of Health Bi-directional regulation of Ube3a Hahn, Klaus University of North $60,000.0 Autism stability by cyclic AMP-dependent Carolina at Chapel 0 Speaks kinase Hill
A longitudinal MRI study of brain Hazlett, University of North $610,416. National development in fragile X syndrome Heather Carolina at Chapel 00 Institutes of Hill Health
Study of fragile X mental retardation Huber, University of Texas $317,077. National protein in synaptic function and Kimberly Southwestern 00 Institutes of plasticity Medical Center Health Mechanisms of mGluR5 function and Huber, University of Texas $406,760. National dysfunction in mouse autism models Kimberly Southwestern 00 Institutes of Medical Center Health Coordinated control of synapse Huber, University of Texas $0.00 Simons development by autism-linked genes Kimberly Southwestern Foundation Medical Center Mechanisms of synapse elimination Huber, University of Texas $434,883. Simons by autism-linked genes Kimberly Southwestern 00 Foundation Medical Center Making the connection between Jacob, John Medical Research $125,635. Simons autism, serotonin and hedgehog Council-National 00 Foundation signaling Institute for Medical Research
Genetically defined stem cell models Jaenisch, Whitehead Institute $350,000. Simons of Rett and fragile X syndrome Rudolf for Biomedical 00 Foundation Research
Quantitative proteomic approach Jin, Peng Emory University $75,000.0 Simons towards understanding and treating 0 Foundation autism TrkB agonist therapy for Katz, David Case Western $147,806. Autism sensorimotor dysfunction in Rett Reserve University 00 Speaks syndrome
MicroRNAs in synaptic plasticity and Kelleher, Massachusetts $131,220. National behaviors relevant to autism Raymond General Hospital 00 Institutes of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Regulation of 22q11 genes in Lamantia, The George $308,631. National embryonic and adult forebrain Anthony Washington 00 Institutes of University Health The role of MeCP2 in Rett syndrome LaSalle, University of $382,858. National Janine California, Davis 00 Institutes of Health Physiological studies in a human Levine, Eric University of $60,000.0 Autism stem cell model of 15q duplication Connecticut 0 Speaks syndrome
Studying Rett and Fragile X Li, Yun Whitehead Institute $0.00 Brain & syndrome in human ES cells using for Biomedical Behavior TALEN technology Research Research Foundation
Modulation of fxr1 splicing as a Lin, Michael Stanford University $0.00 Department treatment strategy for autism in of Defense fragile X syndrome Revealing protein synthesis defects Lin, Michael Stanford University $340,520. National in fragile X syndrome with new 00 Institutes of chemical tools Health
A family-genetic study of autism and Losh, Molly Northwestern $751,420. National fragile X syndrome University 00 Institutes of Health
Neurobiology of RAI1, the causal Luo, Liqun Stanford University $155,380. Simons gene for Smith-Magenis syndrome 00 Foundation
Mesocorticolimbic dopamine circuitry Malenka, Stanford University $436,362. Simons in mouse models of autism Robert 00 Foundation
Functional and anatomical recovery McCoy, University of North $56,000.0 Autism of synaptic deficits in a mouse model Portia Carolina at Chapel 0 Speaks of Angelman Syndrome Hill
Investigating the homeostatic role of McGraw, Baylor College of $35,832.0 National MeCP2 in mature brain Christopher Medicine 0 Institutes of Health A stem cell based platform for Nazor, Scripps Research $0.00 Autism identification of common defects in Kristopher Institute Speaks autism spectrum disorders
Role of intracellular mGluR5 in fragile O'Malley, Washington $75,000.0 Simons X syndrome and autism Karen University in St. 0 Foundation Louis L-type calcium channel regulation of Panagiotak Stanford University $33,002.0 National neuronal differentiation os, Georgia 0 Institutes of Health Mouse models of human autism Parada, University of Texas $400,000. Simons spectrum disorders: Gene targeting Luis Southwestern 00 Foundation in specific brain regions Medical Center Mechanism of UBE3A imprint in Powell, University of $34,439.0 National neurodevelopment Weston California, Davis 0 Institutes of Health This document is for discussion purposes only and does not reflect the decisions of the IACC
MeCP2 modulation of BDNF Pozzo- University of $314,059. National signaling: Shared mechanisms of Miller, Alabama at 00 Institutes of Rett and autism Lucas Birmingham Health The role of intracellular metabotropic Purgert, Washington $13,400.0 National glutamate receptor 5 at the synapse Carolyn University in St. 0 Institutes of Louis Health
Identification of targets for the Ramesh, Massachusetts $0.00 Simons neuronal E3 ubiquitin ligase PAM Vijaya General Hospital Foundation
Pathophysiology of MeCP2 spectrum Ramocki, Baylor College of $179,981. National disorders Melissa Medicine 00 Institutes of Health Underlying mechanisms in a Regehr, Harvard Medical $60,000.0 Simons cerebellum-dependent model of Wade School 0 Foundation autism
Longitudinal MRI study of brain Reiss, Allan Stanford University $901,844. National development in fragile X 00 Institutes of Health Emergence and stability of autism in Roberts, University of South $87,314.0 National fragile X syndrome (supplement) Jane Carolina 0 Institutes of Health Emergence and stability of autism in Roberts, University of South $358,000. National fragile X syndrome Jane Carolina 00 Institutes of Health Olfactory abnormalities in the Ronnett, Johns Hopkins $351,575. National modeling of Rett syndrome Gabriele University 00 Institutes of Health A cerebellar mutant for investigating Sahin, Children's Hospital $149,958. Autism mechanisms of autism in Tuberous Mustafa Boston 00 Speaks Sclerosis
Sex differences in early brain S antelli, University of North $155,873. National development; Brain development in Rebecca Carolina at Chapel 00 Institutes of Turner syndrome Hill Health Cortactin and spine dysfunction in Seese, University of $32,875.0 National fragile X Ronald California, Irvine 0 Institutes of Health
New approaches to local translation: Segal, Dana-Farber Cancer $419,095. National SpaceSTAMP of proteins Rosalind Institute 00 Institutes of synthesized in axons Health The role of genetics in Siegel, University of $60,000.0 Simons communication deficits in autism Steven Pennsylvania 0 Foundation spectrum disorders
Upper motor neuron plasticity in the Smirnakis, Baylor College of $62,500.0 Simons MeCP2-duplication syndrome of Stelios Medicine 0 Foundation autism
Dysregulation of protein synthesis in Smith, National Institutes of $1,117,73 National fragile X syndrome Carolyn Health 1.00 Institutes of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Grammatical development in boys Sterling, University of $148,500. National with fragile X syndrome and autism Audra Wisconsin - Madison 00 Institutes of Health Aberrant synaptic form and function Sulzer, Columbia University $300,000. Simons due to TSC-mTOR-related mutation David 00 Foundation in autism spectrum disorders Understanding the basic Sweatt, J. The University of $60,000.0 Simons neurobiology of Pitt-Hopkins David Alabama at 0 Foundation syndrome Birmingham
Investigation of protocadherin-10 in Tsai, Nien- University of Texas $53,942.0 National MEF2- and FMRP-mediated synapse Pei Southwestern 0 Institutes of elimination Medical Center Health
Probing a monogenic form of autism Tsien, Stanford University $0.00 Simons from molecules to behavior Richard Foundation Fragile X syndrome target analysis Tuschl, The Rockefeller $134,477. Simons and its contribution to autism Thomas University 00 Foundation
Translational regulation of adult Zhao, Xinyu University of $396,944. National neural stem cells Wisconsin - Madison 00 Institutes of Health
Dysregulation of mTOR signaling in Zukin, R. Albert Einstein $72,034.0 National fragile X syndrome (supplement) Suzanne College of Medicine 0 Institutes of of Yeshiva University Health
Dysregulation of mTOR signaling in Zukin, R. Albert Einstein $415,000. National fragile X syndrome Suzanne College of Medicine 00 Institutes of of Yeshiva University Health
Genetic rescue of fragile X syndrome Zukin, R. Albert Einstein $0.00 Simons in mice by targeted deletion of PIKE Suzanne College of Medicine Foundation of Yeshiva University
2.S.E
Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years. Principal Project Title Institution Funding Funder Investigator
Single-unit recordings from the Adolphs, California Institute of $0.00 Simons amygdala in people with autism Ralph Technology Foundation
Direct recording from autism brains Adolphs, California Institute of $60,074.0 Simons Ralph Technology 0 Foundation
This document is for discussion purposes only and does not reflect the decisions of the IACC
Assessing sleep regulation, sleep- Aton, Sara University of $45,000.0 Brain and dependent memory consolidation, and J. Pennsylvania 0 Behavior sleep-dependent synaptic plasticity in Research mouse genetic models of Foundation schizophrenia and autism spectrum disorders
Epileptiform discharges and its Barnes, Vanderbilt University $0.00 Health relation to cognition and behavior in Gregory Resources children with autism spectrum and Services disorders Administratio n Molecular mechanisms linking early Benke, University of $333,473. National life seizures, autism and intellectual Timothy Colorado Denver 00 Institutes of disability Health
Altered gastrointestinal function in the Bornstein, University of $0.00 Department neuroligin-3 mouse model of autism Joel Melbourne of Defense
Selective disruption of hippocampal Danzer, Cincinnati Children's $14,596.0 National dentate granule cells in autism: Impact Steve Hospital Medical 0 Institutes of of PTEN deletion (supplement) Center Health
Selective disruption of hippocampal Danzer, Cincinnati Children's $411,292. National dentate granule cells in autism: Impact Steve Hospital Medical 00 Institutes of
of PTEN deletion Center Health
The role of mTOR inhibitors in the Galanopou Albert Einstein $0.00 Autism treatment of autistic symptoms in lou, Aristea College of Medicine Speaks symptomatic infantile spasms of Yeshiva University
Characterization of the sleep Goldman, Vanderbilt University $150,000. Autism phenotype in adolescents and adults Suzanne 00 Speaks with autism spectrum disorder
Neuroendocrine regulation of Han, Joan National Institutes of $402,805. National metabolism and neurocognition Health 00 Institutes of Health
Altered gastrointestinal function in the Hill, Elisa University of $0.00 Department neuroligin-3 mouse model of autism Melbourne of Defense
Salivary melatonin as a biomarker for Laudensla University of $0.00 Autism response to sleep interventions in ger, Mark Colorado Denver Speaks children with autism
Characterizing sleep disorders in O'Hara, Stanford University $225,081. Simons
autism spectrum disorder Ruth 00 Foundation
This document is for discussion purposes only and does not reflect the decisions of the IACC
Molecular components of A-type K+ Rudy, New York University $363,366. National channels Bernardo School of Medicine 00 Institutes of Health
Self-regulation and sleep in children Schwichten University of $87,899.0 National at risk for autism spectrum disorders berg, Amy California, Davis 0 Institutes of Health
The effects of disturbed sleep on Stickgold, Beth Israel $90,480.0 Autism sleep-dependent memory Robert Deaconess Medical 0 Speaks consolidation and daily function in Center
individuals with ASD Treatment of medical conditions Swedo, National Institutes of $339,591. National among individuals with autism Susan Health 00 Institutes of
spectrum disorders Health
Sensory mechanisms and self-injury Symons, University of $447,738. National Frank Minnesota 00 Institutes of Health
Functional neuroimaging of attention Yerys, University of $192,365. National in autism Benjamin Pennsylvania/Childr 00 Institutes of en's Hospital of Health Philadelphia
Altered gastrointestinal function in Young, University of $0.00 Department the neuroligin-3 mouse model of Heather Melbourne of Defense autism
2.S.F
Launch two studies that focus on prospective characterization of children with reported regression to investigate potential risk factors by 2012. IACC Recommended Budget: $4,500,000 over 5 years.
Principal Project Title Institution Funding Funder Investigator
Investigating the etiology of childhood Pelphrey, Yale University $149,953. Simons disintegrative disorder Kevin 00 Foundation
Neuroimmunologic investigations of Swedo, National Institutes of $101,877. National
autism spectrum disorders (ASD) Susan Health 00 Institutes of Health
2.S.G
Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
This document is for discussion purposes only and does not reflect the decisions of the IACC
Principal Project Title Institution Funding Investigator Funder
Simons Variation in Individuals Project Bernier, University of $436,833. Simons
(VIP) Site Raphael Washington 00 Foundation
Simons Variation in Individuals Project Buckner, Harvard University $137,106. Simons (VIP) Imaging Analysis Site Randy 00 Foundation
Simons Variation in Individuals Project Chung, Columbia University $73,534.0 Simons (Simons VIP) Principal Investigator Wendy 0 Foundation
Gift
Simons Variation in Individuals Project Chung, Columbia University $126,453. Simons (VIP) Principal Investigator Wendy 00 Foundation
Autistic traits: Life course & genetic Constantin Washington $531,127. National
structure o, John University 00 Institutes of Health
ACE Center: Neuroimaging signatures Dapretto, University of $191,823. National of autism: Linking brain function to Mirella California, Los 00 Institutes of genes and behavior Angeles Health
The genetic basis of mid-hindbrain Dobyns, Seattle Children's $798,866. National
malformations William Hospital 00 Institutes of Health
Simons Variation in Individuals Project Faucett, Weis Center For $98,087.0 Simons (VIP) Recruitment Coordination Site W.Andrew Research - 0 Foundation Geisinger Clinc
Genetic investigations of motor Fernandez, Yale University $62,136.0 Simons stereotypies Thomas 0 Foundation
ACE Center: Genetics of language & Geschwind University of $252,243. National social communication: Connecting , Daniel California, Los 00 Institutes of
genes to brain & cognition Angeles Health Simons Variation in Individual Project Hanson, Children's Hospital $0.00 Simons
(Simons VIP) Core Leader Gift Ellen Boston Foundation Simons Variation in Individuals Project Hanson, Children's Hospital $768,296. Simons (VIP) Site Boston 00 Foundation
A neuroimaging study of twin pairs Hardan, Stanford University $625,557. National
with autism Antonio 00 Institutes of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
A collaborative translational autism Herman, Nationwide $903,888. Department research program for the military. Gail Children's Hospital 00 of Defense - Air Force
Autism: Neuropeptide hormones and Jacob, University of Illinois $185,338. National potential pathway genes Suma at Chicago 00 Institutes of Health
Genetic dissection of restricted Kim, Soo- Seattle Children's $177,736. National repetitive behavior (RRB) Jeong Hospital 00 Institutes of Health
Factors influencing early associative Knoll, University of $53,000.0 Autism learning as a precursor to social Allison Southern California 0 Speaks behavior heterogeneity
Simons Variation in Individuals Kochel, Baylor College of $466,763. Simons Project (VIP) Site Robin Medicine 00 Foundation
Comprehensive phenotypic Ledbetter, Weis Center for $62,500.0 Simons characterization of the 17q12 David Research - 0 Foundation deletion syndrome Geisinger Clinc
Identifying the gene in 17q12 Lese Emory University $180,140. Simons responsible for neuropsychiatric Martin, 00 Foundation phenotypes Christa
Simons Variation in Individuals Lese Emory University $706,044. Simons
Project (Simons VIP) Martin, 00 Foundation Christa
A family-genetic study of language in Losh, Molly Northwestern $391,295. National
autism University 00 Institutes of Health
High throughput sequencing of Lu, James Baylor College of $39,432.0 National autism spectrum disorder (ASD) Medicine 0 Institutes of endophenotypes Health
Neural correlates of restricted, Manoach, Massachusetts $0.00 Department repetitive behaviors in autism Dara General Hospital of Defense
spectrum disorders Children with 7q11.23 duplication Mervis, University of $125,000. Simons syndrome: shared characteristics Carolyn Louisville 00 Foundation with autism
Characterization of infants and Nelson, Boston Children's $190,766. Simons toddlers with the 16p copy-number Charles Hospital 00 Foundation variation
This document is for discussion purposes only and does not reflect the decisions of the IACC
Language processing in children with Ousley, Emory University $0.00 Simons 22q11 deletion syndrome and autism Opal Foundation Developmental neurogenetics in Pelphrey, Yale University $124,769. Simons adolescents with autism Kevin 00 Foundation
Animal model of genetics and social Platt, Duke University $791,070. National behavior in autism spectrum Michael 00 Institutes of disorders Health
Social cognition in 22q11.2 deletion Radoeva, State University of $0.00 Autism syndrom (DS) adolescents with ASD Petya New York Upstate Speaks vs. without ASD: Imaging and genetic Medical University correlates Simons Variation in Individuals Roberts,Tim Children's Hospital $736,449. Simons Project (VIP) Functional Imaging Site of Philadelphia 00 Foundation
Simons Variation in Individuals Roberts,Tim Children's Hospital $217,322. Simons Project (VIP) Structural Imaging and of Philadelphia 00 Foundation Phenotyping Site - SCAP-local
Neural correlates of restricted, Santangelo, Massachusetts $0.00 Department repetitive behaviors in autism Susan General Hospital of Defense spectrum disorders Genome-wide identification of Santelli, University of North $611,005. National variants affecting early human brain Rebecca Carolina at Chapel 00 Institutes of development Hill Health
Relating copy number variants to Sebat, University of $322,286. Simons head and brain size in Jonathan California, San 00 Foundation neuropsychiatric disorders Diego Simons Variation in Individuals Sherr, Elliott University of $320,196. Simons Project (VIP) Functional Imaging Site California, San 00 Foundation Francisco
Simons Variation in Individuals Sherr, Elliott University of $513,646. Simons Project (VIP) Core Neuroimaging California, San 00 Foundation Support Site Francisco
Simons Variation in Individuals Sherr, Elliott University of $1,299,08 Simons Project (Simons VIP) Core Leader California, San 3.00 Foundation Gift Francisco Genomic and epigenomic effects of Urban, Stanford University $2,355,00 National large CNV in neurons from iPSC Alexander 0.00 Institutes of Health Simons Variation in Individuals Vaughan, Columbia University $136,125. Simons Project (VIP) Statistical Core Site Roger 00 Foundation
Characterizing the genetic systems Wall, Harvard Medical $120,328. National of autism through multi-disease Dennis School 00 Institutes of analysis (supplement) Health Characterizing the genetic systems Wall, Harvard Medical $524,280. National of autism through multi-disease Dennis School 00 Institutes of analysis Health Social processing, language, and Webb, Sara University of $150,000. Autism executive functioning in twin pairs: Washington 00 Speaks Electrophysiological and behavioral This document is for discussion purposes only and does not reflect the decisions of the IACC
endophenotypes Functional imaging of flexibility in Yerys, Children's Research $132,748. National autism: Informed by SLC6A4 Benjamin Institute 00 Institutes of Health 2.L.A
Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years. Principal Project Title Institution Funding Funder Investigator
Longitudinal characterization of Anderson, University of Utah $182,352. National functional connectivity in autism Jeffrey 00 Institutes of Health
Pediatric brain imaging Giedd, Jay National Institutes of $2,419,58 National Health 3.00 Institutes of Health
MRI study of brain development in Hazlett, University of North $127,479. Autism
school age children with autism Heather Carolina at Chapel 00 Speaks Cody Hill
Amygdala connectivity in autism Johnson, University of $49,934.0 National spectrum disorder Ryan California, Davis 0 Institutes of Health
Understanding the etiological Keehn, Boston Children's $46,000.0 Autism significance of attentional Brandon Hospital 0 Speaks disengagement in infants at-risk for ASD
Investigation of the link between early Kleinhans, University of $0.00 Autism brain enlargement and abnormal Natalia Washington Speaks functional connectivity in autism
spectrum disorders Electrophysiologic biomarkers of McEvoy, University of $28,600.0 Autism language function in autism spectrum Kevin California, Los 0 Speaks disorders Angeles
20-year outcome of autism McMahon, University of Utah $149,964. Autism William 00 Speaks
ACE Network: A longitudinal MRI Piven, University of North $2,619,59 National study of infants at risk for autism Joseph Carolina at Chapel 0.00 Institutes of Hill Health
ACE Network: A longitudinal MRI Piven, University of North $565,115. National study of infants at risk for autism Joseph Carolina at Chapel 00 Institutes of (supplement) Hill Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
2.L.B
Launch at least three studies which evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015. IACC Recommended Budget: $7,200,000 over 5 years. Principal Project Title Institution Funding Funder Investigator
The Brain Genomics Superstruct Buckner, Harvard University $150,000. Simons Project Randy 00 Foundation
Functional neuroimaging of Dichter, University of North $162,369. National psychopharmacologic intervention for Gabriel Carolina at Chapel 00 Institutes of
autism Hill Health
ACE Center: Predicting risk and Jones, Emory University $329,264. National resilience in ASD through social visual Warren 00 Institutes of engagement Health
Local functional connectivity in ASD Kenet, Tal Massachusetts $50,811.0 Simons General Hospital 0 Foundation
A study of autism Krieger, University of $162,232. Simons Abba Pennsylvania 00 Foundation
Near-infrared spectroscopy studies of Pelphrey, Yale University $149,917. Autism early neural signatures of autism Kevin 00 Speaks
ACE Center: Auditory perception and Shinn- Boston University $288,440. National perceptual organization in minimally Cunningha 00 Institutes of verbal children with ASD m, Barbara Health
2.O
Not specific to any objective
Principal Project Title Institution Funding Funder Investigator
Towards an endophenotype for Adolphs, California Institute of $380,304. National
amygdala dysfunction Ralph Technology 00 Institutes of Health
Multimodal studies of executive Agam, Massachusetts $54,570.0 National function deficits in autism spectrum Yigal General Hospital 0 Institutes of disorders Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Characterizing the regulatory Ahituv, University of $57,964.0 Simons pathways and regulation of AUTS2 Nadav California, San 0 Foundation Francisco
Autism and the insula: Genomic and Allman, California Institute of $254,696. Simons neural circuits John Technology 00 Foundation
Transcriptional responsiveness in Alter, Mark University of $0.00 Simons lymphoblastoid cell lines Pennsylvania Foundation
Role of CNTNAP2 in neuronal Anderson, Stanford University $53,500.0 Autism structural development and synaptic Garret 0 Speaks transmission
Multisensory processing in autism Angelaki, Baylor College of $60,000.0 Simons Dora Medicine 0 Foundation
The social brain in schizophrenia and Assaf, Hartford Hospital $594,733. National autism spectrum disorders Michal 00 Institutes of Health
ACE Center: Ontogeny and neural Bachevalie Emory University $314,068. National basis of social visual engagement in r, Jocelyne 00 Institutes of monkeys Health
Learning and plasticity in the human Baker, National Institutes of $351,533. National brain Christophe Health 00 Institutes of r Health
The neural bases of top-down Banerjee, City College of New $27,578.0 National attentional control in autism spectrum Snigdha York 0 Institutes of disorders Health
PI3K/mTOR signaling as a novel Bassell, Emory University $0.00 Autism biomarker and therapeutic target in Gary Speaks autism
Eye movement dynamics in autism Behrmann, Carnegie Mellon $0.00 Simons spectrum disorders Marlene University Foundation
Social and affective components of Bellugi, Salk Institute For $317,715. National
communication Ursula Biological Studies 00 Institutes of Health
Early expression of autism spectrum Ben-Ari, Neurochlore $0.00 Simons disorder in experimental animals Yehezkel Foundation
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Taste, smell, and feeding behavior in Bennetto, University of $570,508. National autism: A quantitative traits study Loisa Rochester 00 Institutes of Health
Structural and functional Berman, Children's Hospital $157,905. National neuroimaging of the auditory system Jeffrey of Philadelphia 00 Institutes of in autism Health
Genetic studies of autism-related Bhat, The University of $489,104. Simons
Drosophila neurexin and neuroligin Manzoor North Carolina at 00 Foundation Chapel Hill
Engrailed targets and the control of Blagburn, University of Puerto $352,100. National synaptic circuits in Drosophila Jonathan Rico Medical 00 Institutes of Sciences Campus Health
The genetic control of social behavior Blanchard, University of Hawai'i $201,966. National in the mouse (supplement) Robert at Manoa 00 Institutes of Health
Elucidation of the developmental role Bomar, University of $31,474.0 National of Jakmip1, an autism-susceptibility Jamee California, Los 0 Institutes of gene Angeles Health
Multimodal neuroimaging of motor Buard, University of $56,000.0 Autism dysfunction in autism spectrum Isabelle Colorado Denver 0 Speaks disorders
Controlling interareal gamma Buschman, Massachusetts $84,775.0 National coherence by optogenetics, Timothy Institute of 0 Institutes of pharmacology and behavior Technology Health
Neurobehavioral investigation of Cascio, Vanderbilt University $162,666. National tactile features in autism spectrum Carissa 00 Institutes of disorders Health
Development of brain connectivity in Castellanos New York University $0.00 Autism autism , Francisco School of Medicine; Speaks Xavier; University of Lord, Michigan Catherine Neocortical mechanisms of Chang, University of $239,255. National categorical speech perception Edward California, San 00 Institutes of Francisco Health
Characterization of the pathological Chauhan, Research $0.00 Department and biochemical markers that Abha Foundation for of Defense correlate to the clinical features of Mental Hygiene, Inc. autism Corticothalamic circuit interactions in Chen, Boston Children's $250,000. Simons autism Chinfei Hospital 00 Foundation
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Identification of genetic pathways Cherra, University of $47,114.0 National that regulate neuronal circuits in C. Salvatore California, San 0 Institutes of elegans Diego Health
SHB: Type II (INT): Synthesizing self- Cheung, University of $798,912. National model and mirror feedback imageries Sen-ching Kentucky Research 00 Science with applications to behavior Foundation Foundation modeling for children with autism
The role of the GRIP protein complex Chiu, Shu- Johns Hopkins $0.00 Brain & in AMPA receptor trafficking and Ling University Behavior autism spectrum disorders Research Foundation
Abnormal connectivity in autism Clark, Kristi University of $30,000.0 Brain & A. California, Los 0 Behavior Angeles Research Foundation
Caspr2 as an autism candidate gene: Comoletti, University of $312,000. National A proteomic approach to function & Davide Medicine & Dentistry 00 Institutes of structure of New Jersey - Health Robert Wood Johnson Medical School
A neural model of fronto-parietal Contreras- University of $183,960. National mirror neuron system dynamics Vidal, Jose Maryland 00 Institutes of Health Psychobiological investigation of the Corbett, Vanderbilt University $347,490. National socioemotional functioning in autism Blythe 00 Institutes of Health The role of the new mTOR complex, Costa- Baylor College of $625,998. Department mTORC2, in autism spectrum Mattioli, Medicine 00 of Defense - disorders Mauro Autism Research Program
Atypical architecture of prefrontal Courchesne University of $335,103. Simons cortex in young children with autism , Eric California, San 00 Foundation Diego Functional analysis of patient Cowan, McLean Hospital $62,475.0 Simons mutations in EPHB2, an ASD Christopher 0 Foundation candidate gene- Core
Neural mechanisms of imitative Cross, University of $33,128.0 National behavior: Implications for mental Kathryn California, Los 0 Institutes of health Angeles Health
Behavioral and neural correlates of Damiano, University of North $0.00 Autism reward motivation in children with Cara Carolina at Chapel Speaks autism spectrum disorders Hill
RNA dysregulation in autism Darnell, The Rockefeller $125,000. Simons Robert University 00 Foundation
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Functional analysis of EFR3A De Camilli, Yale University $31,250.0 Simons mutations associated with autism Pietro 0 Foundation
CLARITY: circuit-dynamics and Deisseroth, Stanford University $124,320. Simons connectivity of autism-related Karl 00 Foundation behavior
Self-injurious behavior: An animal Devine, University of Florida $0.00 Department model of an autism endophenotype Darragh of Defense CAREER: The role of prosody in Dilley, Michigan State $0.00 National word segmentation and lexical Laura University Science access Foundation Mapping functional connectivity Eggebrecht, Washington $55,170.0 Autism networks in autism spectrum disorder Adam University in St. 0 Speaks with diffuse optical tomography Louis
Executive function in children with Ellis- University of $564,177. National typical and atypical language abilities Weismer, Wisconsin - Madison 00 Institutes of Susan Health
Magnetoencephalographic studies of Embick, University of $321,156. National lexical processing and abstraction in David Pennsylvania 00 Institutes of autism Health
Functional properties and directed Engell, Yale University $55,670.0 National connectivity in the face-processing Andrew 0 Institutes of network Health
EEG-based assessment of functional Ewen, Kennedy Krieger $175,042. National connectivity in autism Joshua Institute 00 Institutes of Health
Characterizing mechanistic Fair, Oregon Health & $611,788. National heterogeneity across ADHD and Damien Science University 00 Institutes of autism Health
Electrophysiological response to Faja, Susan University of $89,670.0 National executive control training in autism Washington 0 Institutes of Health
Molecular controls over callosal Fame, Ryan Harvard University $42,232.0 National projection neuron subtype 0 Institutes of specification and diversity Health
Neural mechanisms of tactile Feldman, University of $255,940. National sensation in rodent somatosensory Daniel California, Berkeley 00 Institutes of cortex Health Inhibitory mechanisms for sensory Feldman, University of $328,644. National map plasticity in cerebral cortex Daniel California, Berkeley 00 Institutes of Health Shank3 in synaptic function and Feng, Massachusetts $401,250. National autism Guoping Institute of 00 Institutes of Technology Health
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Enhancing neurobehavioural and Fielding, Monash University $14,000.0 Brain & clinical definitions in autism spectrum Joanne 0 Behavior disorders Research Foundation
Preference acquisition in children Filliter, Dalhousie University $0.00 Autism and adolescents with and without Jillian Speaks autism spectrum disorder
Behavioral, fMRI, and anatomical Fischer, Massachusetts $47,114.0 National MRI investigations of attention in Jason Institute of 0 Institutes of autism Technology Health
Multimodal imaging of social brain Fishman, San Diego State $150,036. National networks in ASD Inna University 00 Institutes of Health
Examining connectivity patterns of Fishman, San Diego State $40,000.0 Autism brain networks participating in social Inna University 0 Science cognition in ASD Foundation
CAREER: Statistical models and Fletcher, University of Utah $8,000.00 National classification of time-varying shape Preston Science Thomas Foundation
The role of FOX-1 in Fogel, Brent University of $145,757. National neurodevelopment and autistic California, Los 00 Institutes of spectrum disorder Angeles Health Neural mechanisms underlying an Foss-Feig, Vanderbilt University $0.00 Autism extended multisensory temporal Jennifer Speaks binding window in ASD Brain bases of language deficits in Gabrieli, Massachusetts $614,180. National SLI and ASD John Institute of 00 Institutes of Technology Health
The role of CNTNAP2 in embryonic Gaiano, Johns Hopkins $0.00 Simons neural stem cell regulation Nicholas University School of Foundation Medicine Understanding the role of Epac2 in Gao, Ruoqi Northwestern $47,232.0 National cognitive function University 0 Institutes of Health
Dual modulators of GABA-A and Gee, Kelvin University of $615,849. Department Alpha7 nicotinic receptors for treating California, Irvine 00 of Defense - autism Autism Research Program
A functional genomic analysis of the Geschwind, University of $256,413. Simons cerebral cortex Daniel California, Los 00 Foundation Angeles
Probing the temporal dynamics of Ghuman, University of $0.00 Brain & aberrant neural communication and Avniel S. Pittsburgh Behavior its relation to social processing Research deficits in autism spectrum disorders Foundation This document is for discussion purposes only and does not reflect the decisions of the IACC
RI: Small: Addressing visual analogy Goel, Ashok Georgia Tech $284,454. National problems on the raven's intelligence Research 00 Science test Corporation Foundation
Role of negative regulators of FGF Golonzhka, University of $45,000.0 Brain & signaling in frontal cortex Olga California, San 0 Behavior development and autism Francisco Research Foundation
Monolingual and bilingual infants' Gouvea, Florida International $144,100. National sensitivity to agreement morphology Ana University 00 Institutes of in Spanish Health
Using fruit flies to map the network of Greenspan, University of $156,245. Simons autism-associated genes Ralph California, San 00 Foundation Diego
Face perception: Mapping Grill- Stanford University $0.00 National psychological spaces to neural Spector, Science responses Kalanit Foundation Identification and analysis of ASD Gross, Emory University $66,500.0 Simons patients with PI3K/mTOR Christina 0 Foundation signalopathies
Spatial attention in autism spectrum Grubb, New York University $28,600.0 Autism disorders Michael 0 Speaks
Identification of candidate genes at Gupta, Yale University $168,839. National the synapse in autism spectrum Abha 00 Institutes of disorders Health Functional analysis of patient Gupta, Yale University $177,512. Simons mutations in EPHB2, an ASD Abha 00 Foundation candidate gene- Project 1
The neural substrates of social Gupta, University of Iowa $15,865.0 National interactions Rupa 0 Institutes of Health
Molecular signatures of autism genes Gusella, Massachusetts $62,500.0 Simons and the 16p11.2 deletion James General Hospital 0 Foundation
Development of the functional neural Haist, Frank University of $507,685.00 National
systems for face expertise California, San Diego Institutes of Health
Cerebellar plasticity and learning in a Hansel, University of Chicago $156,250.00 Simons mouse model of autism Christian Foundatio n
Canonical neural computation in Heeger, New York University $365,741.00 Simons
autism spectrum disorders David Foundatio n
This document is for discussion purposes only and does not reflect the decisions of the IACC
Defining cells and circuits affected Heintz, The Rockefeller $336,872.00 Simons in autism spectrum disorders Nathaniel University Foundatio n
Homeostatic regulation of Henry, University of Michigan $32,747.00 National presynaptic function by dendritic Fredrick Institutes mTORC1 of Health
3 Tesla 31Phosphorus magnetic Herbert, Treatment Research $3,250.00 Autism resonance spectroscopy in disorder Martha and Neuroscience Research with abnormal bioenergetics Evaluation of Institute Neurodevelopmental Disorders (TRANSCEND) Research Laboratory, Massachusetts General Hospital
Perturbed cortical patterning in Hevner, Seattle Children's $60,000.00 Simons autism Robert Hospital Foundatio n
Integrative functions of the planum Hickok, University of $34,768.00 National temporale (supplement) Gregory California, Irvine Institutes of Health
Integrative functions of the planum Hickok, University of $440,810.00 National
temporale Gregory California, Irvine Institutes of Health
Neural basis of cross-modal Hillyard, University of $158,282.00 National
influences on perception Steven California, San Diego Science Foundatio n
Exploring the uncanny valley Hodgins, Carnegie Mellon $0.00 National Jessica University Science Foundatio n Collaborative research: Learning Holt, Lori Carnegie Mellon $0.00 National
complex auditory categories University Science Foundatio n Vasopressin receptor polymorphism Hopkins, Georgia State $395,156.00 National and social cognition William University Institutes of Health
Proteome and interaction networks Howley, Harvard Medical $156,250.00 Simons in autism Peter School Foundatio n
Functional role of IL-6 in fetal brain Hsiao, Elaine California Institute of $42,232.00 National development and abnormal Technology Institutes behavior of Health
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Collaborative research: Modeling Huber, David University of $0.00 National perception and memory: Studies in California, San Diego Science
priming Foundatio n High throughput screen for small Huganir, Johns Hopkins $405,000.00 National molecule probes for neural network Richard University Institutes development of Health
High metabolic demand of fast- Inan, Melis Weill Cornell Medical $54,500.00 Autism spiking cortical interneurons College Speaks underlying the etiology of autism
Neurobiological signatures of Irwin, Julia Haskins Laboratories, $217,886.00 National audiovisual speech perception in Inc. Institutes children in ASD of Health
Analysis of Shank3 complete and Jiang, Yong- Duke University $481,448.00 National temporal and spatial specific Hui Institutes knockout mice of Health
Stimulus-driven attention deficits in Jiang, University of $0.00 Simons autism Yuhong Minnesota Foundatio n
Macrocephalic autism: Exploring Johnston, University of $0.00 Autism and exploiting the role of PTEN Sean Wisconsin - Madison Speaks
The neural basis of weak central Jou, Roger J. Yale University $13,040.00 Brain & coherence in autism spectrum Behavior disorders Research Foundatio n
Engrailed genes and cerebellum Joyner, Memorial Sloan- $470,003.00 National morphology, spatial gene Alexandra Kettering Cancer Institutes
expression and circuitry Center of Health
Using high definition fiber tracking to Just, Marcel Carnegie Mellon $25,000.00 Autism define developmental neurobiologic University Research mechanisms & a neural basis for Institute behavioral heterogeneity
Neurexin-neuroligin trans-synaptic Kandel, Eric Columbia University $200,000.00 Simons
interaction in learning and memory Foundatio n
Role of neurexin in the amygdala Kandel, Eric Columbia University $175,000.00 Simons and associated fear memory Foundatio n
Retrograde synaptic signaling by Kaplan, Massachusetts $250,000.00 Simons Neurexin and Neuroligin in C. Joshua General Hospital Foundatio
elegans n
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Investigating brain connectivity in Kennedy, California Institute of $88,508.00 National autism at the whole-brain level Daniel Technology Institutes of Health
Investigating brain connectivity in Kennedy, Indiana University $249,001.00 National autism at the whole-brain level Daniel Institutes of Health
Investigating brain organization and Kennedy, California Institute of $0.00 Brain & activation in autism at the whole- Daniel P. Technology Behavior brain level Research Foundatio n
Developing novel automated Kimchi, Tali Weizmann Institute of $0.00 Departme apparatus for studying battery of Science nt of social behaviors in mutant mouse Defense
models for autism Excessive cap-dependent Klann, Eric New York University $0.00 Departme translation as a molecular nt of
mechanism underlying ASD Defense
Multimodal brain imaging in autism Kleinhans, University of $167,832.00 National
spectrum disorders Natalia Washington Institutes of Health
Role of GluK6 in cerebella circuitry Kubera, Yale University $58,442.00 National
development Cathryn Institutes of Health
Semaphorin4D and PlexinB1 Kuzirian, Brandeis University $27,814.00 National mediate GABAergic synapse Marissa Institutes development in mammalian CNS of Health
The microstructural basis of Lainhart, University of Utah $332,991.00 National
abnormal connectivity in autism Janet Institutes of Health
ERK signaling in autism associated Landreth, Case Western $51,290.00 Simons with copy number variation of Gary Reserve University Foundatio 16p11.2 n
Development of face processing Lee, Kang University of Toronto $351,984.00 National
expertise Institutes of Health
Multiple systems in theory of mind Leslie, Alan Rutgers, The State $0.00 National
development University of New Science Jersey - New Foundatio Brunswick n Function and structure adaptations Levitt, Pat University of $541,770.00 National
in forebrain development Southern California Institutes of Health
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Genetic model to study the ASD- Levkowitz, Weizmann Institute of $62,500.00 Simons associated gene A2BP1 and its Gil Science Foundatio target PAC1 n
Neurobiological correlates of Lewine, The Mind Research $535,052.00 National language dysfunction in autism Jeffrey Network Institutes
spectrum disorders of Health
Synchronous activity in networks of Lewis, University of $0.00 National electrically coupled cortical Timothy California, Davis Science
interneurons Foundatio n Roles of miRNAs in regulation of Li, XiaoChing Louisiana State $45,000.00 Brain & Foxp2 and in autism University Behavior Research Foundatio n
MTHFR functional polymorphism Liu, Xudong Queen's University $0.00 Departme C677T and genomic instability in the nt of etiology of idiopathic autism in Defense simplex families
Role of major vault protein in autism Lombroso, Yale University $59,972.00 Simons Paul Foundatio n
Pragmatics and semantics in autism Lopez, City University of New $29,155.00 National spectrum disorder Karece York Graduate Institutes School and University of Health Center
Collaborative research: Learning Lotto, University of Arizona $0.00 National
complex auditory categories Andrew Science Foundatio n The impact of Pten signaling on Luikart, Dartmouth College $346,014.00 National neuronal form and function Bryan Institutes of Health
Social interaction and reward in Luscher, University of Geneva $62,496.00 Simons autism: Possible role for ventral Christian Foundatio tegmental area n
Behavioral and neural responses to Luyster, Harvard University $14,935.00 Brain & emotional faces in individuals with Rhiannon J. Behavior ASD Research Foundatio n
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Regulation of spine morphogenesis Maness University of North $185,000.00 National by NrCAM Tidwell, Carolina at Chapel Institutes Patricia Hill of Health
Investigation of a possible role of Maniatis, Columbia University $150,000.00 Simons the protocahderin gene cluster in Tom Foundatio autism n
The cognitive neuroscience of Martin, Alex National Institutes of $1,074,095. National
autism spectrum disorders Health 00 Institutes of Health
Cellular density and morphology in Martinez University of $363,672.00 National the autistic temporal human Cerdeno, California, Davis Institutes cerebral cortex Veronica of Health
Cognitive control of emotion in Mazefsky, University of $102,638.00 National
autism Carla Pittsburgh Institutes of Health
Social brain networks for the McCarthy, Yale University $414,688.00 National detection of agents and intentions Gregory Institutes of Health
Neural underpinning of emotion Meng, Ming Dartmouth College $30,000.00 Brain & perception and its disorders Behavior Research Foundatio n
Mathematical cognition in autism: A Menon, Stanford University $652,461.00 National cognitive and systems neuroscience Vinod Institutes approach of Health
Decoding 'what' and 'who' in the Menon, Stanford University $197,500.00 National auditory system of children with Vinod Institutes autism spectrum disorders of Health
CDI-TYPE II: From language to Mitchell, Tom Carnegie Mellon $0.00 National neural representations of meaning University Science Foundatio n Alterations in brain-wide Mitra, Partha Cold Spring Harbor $300,000.00 Simons neuroanatomy in autism mouse Laboratory Foundatio models n
Cerebellar modulation of frontal Mittleman, University of $302,306.00 National
cortical function Guy Memphis Institutes of Health
Linguistic perspective-taking in Mizuno, Carnegie Mellon $0.00 Autism adults with high-functioning autism: Akiko University Speaks Investigation of the mirror neuron
system
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Sensory processing and integration Molholm, Albert Einstein $548,158.00 National
in autism Sophie College of Medicine Institutes of Yeshiva University of Health
Social behavior deficits in autism: Mooney, State University of $0.00 Autism
Role of amygdala Sandra New York Upstate Speaks Medical Center
HCC:Small:Computational studies Morency, University of $0.00 National
of social nonverbal communication Louis- Southern California Science Philippe Foundatio n Endosomal NHE6 in long-range Morrow, Eric Brown University $62,500.00 Simons connectivity and autism Foundatio n
Motor control and cerebellar Mosconi, University of Texas $157,148.00 National maturation in autism Matthew Southwestern Institutes Medical Center of Health
Motor skill learning in autism Mostofsky, Kennedy Krieger $395,908.00 National Stewart Institute Institutes of Health
Linking local activity and functional Mueller, San Diego State $92,508.00 National connectivity in autism (supplement) Ralph-Axel University Institutes of Health
Linking local activity and functional Mueller, San Diego State $370,304.00 National
connectivity in autism Ralph-Axel University Institutes of Health
Cell adhesion molecules in CNS Mueller, The Scripps $534,562.00 National
development Ulrich Research Institute Institutes of Health
Networked cortical responses to Murias, University of $449,700.00 National movement associated with ASD Michael Washington Institutes of Health
Thalamocortical connectivity in Nair, Aarti San Diego State $28,600.00 Autism children and adolescents with ASD- University Speaks A combined fcMRI and DTI approach
Brain electrophysiology of Naples, Yale University $52,984.00 Autism interactive social stimuli Adam Speaks
Understanding the brain basis of Nebel, Mary Kennedy Krieger $55,200.00 Autism impaired imitation learning in autism Beth Institute Speaks
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How autism affects speech Newman, University of $0.00 National understanding in multitalker Rochelle Maryland, College Institutes environments Park of Health
Experience and cognitive Oakes, Lisa University of $102,038.00 National
development in infancy California, Davis Science Foundatio n Infants' developing representation of Oakes, Lisa University of $0.00 National
object function California, Davis Science Foundatio n Development of ventral stream O'Hearn, University of $137,338.00 National
organization Kirsten Pittsburgh Institutes of Health
Deciphering the function and Oksenberg, University of $0.00 Autism regulation of AUTS2 Nir California, San Speaks Francisco
White matter glial pathology in Ordway, East Tennessee $0.00 Departme autism Gregory State University nt of Defense
Investigation of social brain circuits Osten, Pavel Cold Spring Harbor $175,000.00 Simons in mouse models of the 16p11.2 Laboratory Foundatio locus n
Cell adhesion molecules in autism: Osten, Pavel Cold Spring Harbor $485,438.00 National A whole-brain study of genetic Laboratory Institutes mouse models of Health
Investigation of social brain circuits Osten, Pavel Cold Spring Harbor $60,000.00 Simons and fever-evoked response in Laboratory Foundatio 16p11.2 mice n
Extended tracking of single synaptic Ostrowski, University of $10,819.00 National proteins with upconverting Alexis California; Lawrence Institutes nanoparticles Berkeley National of Health Laboratory
Elucidating the function of class 4 Paradis, Brandeis University $23,015.00 National semaphorins in GABAergic synapse Suzanne Institutes formation (supplement) of Health
Elucidating the function of class 4 Paradis, Brandeis University $336,922.00 National semaphorins in GABAergic synapse Suzanne Institutes formation of Health
Effect of paternal age on mutational Pardo- University of North $222,000.00 National burden and behavior in mice Manuel De Carolina at Chapel Institutes Villena, Hill of Health Fernando
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Transcriptional regulators in normal Parikshak, University of $30,002.00 National human brain development and Neelroop California, Los Institutes autism Angeles of Health
Behavioral and neural processing of Parr, Lisa Emory University $435,600.00 National faces and expressions in nonhuman Institutes
primates of Health
Synaptic processing in the basal Perkel, David University of $377,815.00 National
ganglia Washington Institutes of Health
Neuronal basis of vicarious Platt, Duke University $310,081.00 National reinforcement dysfunction in autism Michael Institutes spectrum disorder of Health
Neural basis of empathy and its Platt, Duke University $0.00 Departme dysfunction in autism spectrum Michael nt of
disorders (ASD) Defense
Diffusion tensor MR spectroscopic Posse, University of New $203,715.00 National imaging in human brain Stefan Mexico Health Institutes Sciences Center of Health
GABAergic dysfunction in autism Puts, Johns Hopkins Autism Nicolaas University $48,000.00 Speaks
MET signaling in neural Qiu, University of Arizona $249,000.00 National
development and circuitry formation Shenfeng Institutes of Health
Neuroligin, oxidative stress and Rand, James Oklahoma Medical $150,000.00 Simons autism Research Foundation Foundatio n
Serotonin signal transduction in two Rasenick, University of Illinois at $0.00 Departme
groups of autistic patients Mark Chicago nt of Defense
Evaluating the time-dependent Richardson, University of $252,622.00 National unfolding of social interactions in Michael Cincinnati Institutes autism of Health
CAREER: Integrative behavioural Robertson, Cornell University $0.00 National and neurophysiological studies of Steven Science normal and autistic cognition using Foundatio
video game environments n Neural synchrony dysfunction of Rojas, University of $100,386.00 National gamma oscillations in autism Donald Colorado Denver Institutes (supplement) of Health
Neural synchrony dysfunction of Rojas, University of $265,073.00 National
gamma oscillations in autism Donald Colorado Denver Institutes of Health
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Auditory and integrative functions of Romanski, University of $387,285.00 National the prefrontal cortex Lizabeth Rochester Institutes of Health
A novel transplantation assay to Rubenstein, University of $60,000.00 Autism study human PTEN ASD alleles in John California, San Speaks GABAergic interneurons Francisco
Development of a connectomic Rubinov, University of $0.00 Brain & functional brain imaging Mikail Cambridge Behavior endophenotype of autism Research Foundatio n
Molecular mechanisms of the Rudenko, University of Michigan $383,267.00 National synaptic organizer alpha-neurexin Gabrielle Institutes of Health
Impact of SynGAP1 mutations on Rumbaugh, The Scripps $789,981.00 National synapse maturation and cognitive Gavin Research Institute - Institutes development Florida of Health
Urokinase-type plasminogen Russo, A.J. Hartwick College $8,505.00 Autism activator plasma concentration and Research its relationship to hepatocyte growth Institute factor (HGF) and GABA levels in autistic children
Cortical dynamics in autism Said, Chris New York University $52,190.00 National Institutes of Health
Multisensory integration in children Saron, University of $192,136.00 National with ASD Clifford California, Davis Institutes of Health
Impairments of theory of mind Saxe, Massachusetts $321,000.00 Simons disrupt patterns of brain activity Rebecca Institute of Foundatio Technology n
CAREER: Typical and atypical Saxe, Massachusetts $86,848.00 National development of brain regions for Rebecca Institute of Institutes theory of mind Technology of Health
Collaborative research: RUI: Schmidt, College of the Holy $0.00 National Perceptual pick-up processes in Richard Cross Science
interpersonal coordination Foundatio n Testing the hyperspecificity Schultz, Children's Hospital of $247,018.00 National hypothesis: A neural theory of Robert Philadelphia Institutes autism of Health
Typical and pathological cellular Schumann, University of $385,000.00 National development of the human Cynthia California, Davis Institutes amygdala of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Glial control of neuronal receptive Shaham, The Rockefeller $418,275.00 National
ending morphology Shai University Institutes of Health
Molecular dissection of calmodulin Shea, University of Iowa $321,473.00 National domain functions Madeline Institutes of Health
The effects of autism on the sign Shield, Boston University $1,188.00 National language development of deaf Aaron Institutes children (supplement) of Health
The effects of autism on the sign Shield, Boston University $59,419.00 National language development of deaf Aaron Institutes children of Health
Autism spectrum disorders and the Shiffrar, Rutgers, The State $0.00 Simons
visual analysis of human motion Maggie University of New Foundatio Jersey n
Metacognition in comparative Smith, J. University at Buffalo, $210,561.00 National
perspective David The State University Institutes of New York of Health
The neural substrates of higher- Solomon, University of $192,500.00 National level learning in autism Marjorie California, Davis Institutes of Health
Learning in autism spectrum Solomon, University of $28,902.00 Brain & disorders Marjorie California, Davis Behavior Research Foundatio n
Brain-behavior interactions and Soulieres, Hospital Riviere-des- $0.00 Brain & visuospatial expertise in autism: a Isabelle Praires, University of Behavior window into the neural basis of Montreal, Canada Research autistic cognition Foundatio n
Computational characterization of Sproat, Oregon Health & $738,723.00 National language use in autism spectrum Richard Science University Institutes disorder of Health
ACE Center: Neuroimaging studies Staib, Yale University $315,268.00 National
of connectivity in ASD Lawrence Institutes of Health
The computational basis of theory of Stanley, California Institute of $103,965.00 National mind in the human brain Damian Technology Institutes of Health
Stimulus preceding negativity and Stavropoulos University of $28,600.00 Autism social stimuli in autism spectrum , Katherine California, San Diego Speaks disorder
This document is for discussion purposes only and does not reflect the decisions of the IACC
Role of neuronal migration genes in Sudarov, Weill Cornell Medical $52,190.00 National synaptogenesis and plasticity Anamaria College Institutes of Health
Function of neurexins Sudhof, Stanford University $473,710.00 National Thomas Institutes of Health
Function and dysfunction of Sudhof, Stanford University $750,000.00 Simons
neuroligins in synaptic circuits Thomas Foundatio n
Modeling 5-HT-absorbing neurons Sze, Ji Albert Einstein $250,500.00 National in neuropathology of autism College of Medicine Institutes of Yeshiva University of Health
Subependymal zone function in Szele, University of Oxford $59,560.00 Simons autism spectrum disorders Francis Foundatio n
Kinetics of drug macromolecule Taylor, University of $712,921.00 National
complex formation Palmer California, San Diego Institutes of Health
Attentional distribution and word Tenenbaum, Women & Infants $50,600.00 Autism
learning in children with autism Elena Hospital Speaks
Influence of attention and arousal Townsend, University of $232,500.00 National on sensory abnormalities in ASD Jeanne California, San Diego Institutes of Health
Imaging PTEN-induced changes in Trachtenberg University of $300,156.00 National adult cortical structure and function , Joshua California, Los Institutes
in vivo Angeles of Health
In vivo targeted gene silencing, a Truitt, Indiana University- $192,500.00 National novel method William Purdue University Institutes Indianapolis of Health
Regulation of synaptogenesis by Tsai, Li-Huei Massachusetts $0.00 Simons
cyclin-dependent kinase 5 Institute of Foundatio Technology n
CAREER: Dissecting the neural Tsao, Doris California Institute of $0.00 National
mechanisms for face detection Technology Science Foundatio n Structural and functional Uddin, Stanford University $168,978.00 National connectivity of large-scale brain Lucina Institutes networks in autism spectrum of Health
disorders Presynaptic regulation of quantal Ullman, Julie University of $33,932.00 National size by the cation/H+ exchangers California, Berkeley Institutes NHE6 & NHE9 of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Functional anatomy of face Ungerleider, National Institutes of $1,660,304. National
processing in the primate brain Leslie Health 00 Institutes of Health
Morphogenesis and function of the Vaccarino, Yale University $409,613.00 National
cerebral cortex Flora Institutes of Health
Neuroimaging of top-down control Vaidya, Georgetown $111,600.00 National and bottom-up processes in Chandan University Institutes childhood ASD (supplement) of Health Neuroimaging of top-down control Vaidya, Georgetown $387,066.00 National and bottom-up processes in Chandan University Institutes
childhood ASD of Health Neuropeptide regulation of juvenile Veenema, Boston College $29,550.00 Brain & social behaviors Alexa Behavior Research Foundatio n
Statistical word learning and non- Venker, University of $33,148.00 National social visual attention in children Courtney Wisconsin - Madison Institutes with autism of Health
Novel computational methods for Verma, University of $725,545.00 National
higher order diffusion MRI in autism Ragini Pennsylvania Institutes of Health
Head-fixed recording of sensory Wang, Princeton University $0.00 Simons learning in mouse autism models Samuel Foundatio n
Defining the dynamics of the default Weaver, Kurt University of $146,025.00 National network with direct brain recordings Washington Institutes
and functional MRI of Health Physiology of attention and Webb, Sara Seattle Children's $341,013.00 National regulation in children with ASD and Hospital Institutes
LD of Health
Characterization of the pathological Wegiel, Research Foundation $0.00 Departme and biochemical markers that Jerzy for Mental Hygiene, nt of correlate to the clinical features of Inc. Defense
autism
Dimensions of mind perception Wegner, Harvard University $0.00 National Daniel Science Foundatio n
Neural basis of behavioral flexibility Weiss, Mount Sinai School of $360,214.00 National Klaudiusz Medicine Institutes of Health BRIGE: Emotion mapping of Welch, Karla University of $174,583.00 National children through human-robot Louisville Research Science interaction and affective computing Foundation Inc Foundatio n
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Neuroprotective effects of oxytocin Welch, Columbia University $25,000.00 Autism receptor signaling in the enteric Martha Research nervous system Institute
The striatal circuitry underlying Wells, Duke University $31,975.00 National autistic-like behaviors Michael Institutes of Health
Role of autism-susceptibility gene, White, University of $0.00 Departme CNTNAP2, in neural circuitry for Stephanie California, Los nt of
vocal communication Angeles Defense
Modulation of RhoA signaling by the Williams, Emory University $30,912.00 National mRNA binding protein hnRNPQ1 Kathryn Institutes of Health
Characterization of the pathological Wisniewski, Research Foundation $0.00 Departme and biochemical markers that Thomas for Mental Hygiene, nt of correlate to the clinical features of Inc. Defense
autism A preliminary investigation of the Wodka, Kennedy Krieger $10,000.00 Organizati neurobehavioral basis of sensory Ericka Institute on for behavior in autism Autism Research
Action anticipation in infants Woodward, University of Chicago $102,258.00 National Amanda Science Foundatio n Dynamic regulation of Shank3 and Worley, Paul Johns Hopkins $646,316.00 National ASD University Institutes of Health
Bayesian variable selection in Yang, Hunter College (City $95,377.00 National generalized linear models with Xiaowei University of New Institutes missing variables York) of Health
Imaging signal transduction in single Yasuda, Duke University $382,200.00 National
dendritic spines Ryohei Institutes of Health
Local connectivity in altered Yizhar, Ofer Weizmann Institute of $62,500.00 Simons excitation/inhibition balance states Science Foundatio n
Young development of a novel PET Young, Larry Emory University $176,000.00 National ligand for detecting oxytocin Institutes receptors in brain (supplement) of Health Young development of a novel PET Young, Larry Emory University $261,360.00 National ligand for detecting oxytocin Institutes
receptors in brain of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
High-throughput DNA sequencing Zador, Cold Spring Harbor $430,650.00 National method for probing the connectivity Anthony Laboratory Institutes of neural circuits at single-neuron of Health
resolution Novel regulatory network involving Zheng, Albert Einstein $208,750.00 National non-coding role of an ASD Deyou College of Medicine Institutes candidate gene PTEN of Yeshiva University of Health
Statistical analysis of biomedical Zhu, Hongtu University of North $326,619.00 National
imaging data in curved space Carolina at Chapel Institutes Hill of Health
Functional analysis of neurexin IV in Zipursky, University of $0.00 Simons
Drosophila Larry California, Los Foundatio Angeles n
The role of neurexin IV in central Zipursky, University of $100,466.00 Simons nervous system development Larry California, Los Foundatio Angeles n
This document is for discussion purposes only and does not reflect the decisions of the IACC