DOCSLIB.ORG

Program & Abstracts

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Program & Abstracts The International Symposium on Ocular Pharmacology and Therapeutics www.isopt.net 10th ISOPTClinical March 7-10, 2013, Paris, France Program & Abstracts Retina Glaucoma Inflammation & Infection Basic External Eye DevelopmentDrug Science Diseases ISOPT is Celebrating its 10th Anniversary 10th ISOPTClinical Contents Welcome . Committees. General Information. Reception & Refreshments. Sponsors & Exhibitors . Scientific Program Thursday, March 7 . Friday, March 8 . Saturday, March 9. Sunday, March 10 . E-Posters . Abstracts . Index of Authors . 2 The International Symposium on Ocular Pharmacology and Therapeutics March 7-10, 2013, Paris, France Dear Colleague, ISOPT is Celebrating its 10th Anniversary! Over the years ISOPT has become a place for formal updates of medical ophthalmology and drug utilization combined with informal meetings of clinicians and drug developers. ISOPT’s vision is to increase knowledge and awareness of drug usage in ophthalmology, reflecting innovations and their utilization in practice. ISOPT’s vision will be reflected in the following missions: • Share treatment algorithms in major ophthalmic indications. • Implement data from clinical studies for daily practice • Facilitate innovation – connecting innovators with practitioners ISOPT offers a relevant and updated scientific program in a relaxed atmosphere leading to direct interactions of its delegates. We welcome you in Paris, and invite you to share experiences and insights, whether your field of interest is in retinal diseases, inflammation, cornea and external diseases, glaucoma or basic science. Ron Neumann, MD Sara Krupsky, MD Symposium Chairpersons 3 10th ISOPTClinical Committees Chairpersons Special Program Advisor S. Krupsky, Israel B.D. Kuppermann, USA R. Neumann, Israel Scientific Advisory Board P.A. Asbell, USA A. Das, USA P. Kaufman, USA H. Reitsamer, Austria E.K. Akpek, USA T. Das, India J.H. Kim, South Korea V.S. Sangwan, India I. Barequet, Israel M.D. De Smet, Belgium S. Kinoshita, Japan L. Schmetterer, Austria T. Barisani, Austria S. Dikstein, Israel U.B. Kompella, USA G. Soubrane, France F. Behar-Cohen, France J. Duan, China B.D. Kuppermann, USA E. Souied, France P. Bernstein, USA R.M. Feldman, USA P. Lanzetta, Italy D.D-S, Tang Liu, USA R. Beuerman, Singapore S.C. Foster, USA L.A. Levin, USA H.S. Uy, Philippines S. Binder, Austria R.W. Fraunfelder, USA X. Li, China R. Vogel, USA B. Bodaghi, France A. Girach, UK P.N. Nagpal, India X. Zhang, China K. Brazzell, USA R. Gurny, Switzerland T. Nakanashi-Ueda, Japan M. Zierhut, Germany A. Bron, UK G. Hollo, Hungary A. Okada, Japan J.G. Cunha-Vaz, Portugal S. Hong, S. Korea A. Okumura, Japan R. Danis, USA J.B. Jonas, Germany C. Paterson, USA Invited Speakers N. Acar, France I. Chowers, Israel H.E. Killer, Switzerland A. Queant, France B. Ambati, USA K. Colby, USA H. Klassen, USA G. Querques, France J. Ambati, USA M.F. Cordeiro, UK A. Koh, Singapore E. Reichel, USA R.E. Anderson, USA G. Coscas, France U. Kompella, USA M. Rodriguez-Aller, S. Androudi, Greece C. Creuzot, France J.S. Korobelnik, France Switzerland E. Akpek, USA R. Dana, USA R. P. Kowalski, USA E. Romanowski, USA P. Aragona, Italy A. Das, USA R. Kowluru, USA Y. Rotenstreich, Israel Y. Arsenijevic, Switzerland M. de Smet, The Netherlands M. Kramer, Israel D.R. Saban, USA P. Asbell, USA C. Deuter, Germany B.D. Kuppermann, USA J. Sahel, France L. Asmus, Germany C. Di Tommaso, Switzerland W. Lagreze, Germany M. Sainz de la Maza, Spain I. Audo, France G. Dorin, USA F. Lallemand, France B. Salomon, France A. Augustin, Germany J. Dowler, UK P. Lanzetta, Italy M. Sawa, Japan F. Bandello, Italy W. Drexler, Austria P. Le Hoang, France L. Schmetterer, Austria I. Barequet, Israel P. Dugel, USA H.G. Lemij, The Netherlands B. Seitz, Germany T. Barisani-Asenbauer, B. Dupas, France B.P. Leroy, France D. Sinha, USA Austria Y. El-Shabrawi, Austria L. Levin, USA G. Soubrane, France C. Baudouin, France C. Ergorul, USA H. Levkovitch-Verbin, Israel E. Souied, France F. Behar-Cohen, France M. Esmaeelpour, Austria A.S. Lewin, Canada O. Stachs, Germany M.W. Belin, USA M. Eydelman, USA J.M. Liebmann, USA D. Tang-Liu, USA G.J. Berdy, USA N. Farman, France T.M. Lietman, USA J. Thorne, USA P. Bernstein, USA R.W. Fraunfelder, USA J.M. Lloves, Spain A. Torriglia, France R. Beuerman, Singapore P. Garg, India A. Loewenstein, Israel E. Touchard, France S. Binder, Austria G. Garhoefer, Austria E. Lydhal, Sweden R. Toyos, USA B. Bodaghi, France D. Garway-Heath, UK F.J. Malecaze, France O. Ucakhan-Gunduz, Turkey S. Bonini, Italy C. Glittenberg, Austria C. Martinho, Portugal P. Udaondo, Spain F. Boscia, Italy M. Goldstein, Israel N.L. Mata, USA P.T.K. Van, Vietnam D. Boyer, USA R. Gurny, Switzerland J.S. Mehta, Singapore G. Van Setten, Sweden D. Brémond-Gignac, France S.H. Hardarson, Iceland E. Miserocchi, Italy D. Veritti, Italy L. Bretillon, France A. Harris, USA K. Miyake, Japan M. Veurink, Switzerland F. Brignole-Baudouin, France J. Heier, USA S. Mohr, USA M. Vidal-Sanz, Spain A. Bron, France R. Herrero-Vanrell, Spain J. Mones, Spain S. Wadsworth, USA A. Bron, UK D. Hinton, USA Q.D. Nguyen, USA M. Weber, France J. Bullock, USA A. Horsager, USA A. Ohira, Japan D. Zack, USA J. Busik, USA J.F. Huang, USA N. Orwa, Israel M. Zarbin, USA R. Caldwell, USA M.M. Iester, Italy M. Paques, France F. Zeiler, Austria M. Calonge, Spain S. Jain, USA S. Patel, USA M. Zhao, France K.V. Chalam, USA J. Jonas, Germany C. Pavesio, UK M. Zierhut, Germany A.A. Chang, Australia T. Kern, USA J. Penn, USA 4 The International Symposium on Ocular Pharmacology and Therapeutics March 7-10, 2013, Paris, France General Information Venue Marriott Rive Gauche Hotel & Conference Center 17 Boulevard Saint Jacques Paris 75014, France Tel: +33 1 4078 7980 Fax: +33 1 4588 4393 Language English is the official language of the Symposium. Registration and Hospitality The registration desk will be located in the entrance to the meetings halls and will be open as follows: Thursday, 7 March 11:00 – 18:00 Saturday, 9 March 07:30 – 17:30 Friday, 8 March 07:30 – 17:30 Sunday, 10 March 07:30 – 12:00 Symposium Kit and Name Badge Upon registering you will receive your kit, containing your personal name badge. Please remember to wear your name badge to all symposium activities and to the Welcome Reception. Please note there will be a charge of €30 to replace lost badges. Internet Facilities Free internet and e-mail facilities are located in the exhibition area and are available during exhibition opening hours. Please be considerate of fellow participants when using the facilities. Certificate of Attendance A certificate of attendance will be available at the registration desk on Saturday, March 9th, noon time. Exhibition Opening Hours All participants are invited to view the exhibition in the hotel. Exhibition opening hours are as follows: Thursday, 7 March 13:00 - 20:00 Friday, 8 March 10:00 - 18:00 Saturday, 9 March 10:00 - 18:00 Oral Presentations If using a PowerPoint presentation, please note you need to bring it on a CD or on a memory stick (using the USB port in the computer) and load it on one of the Symposium computers in the Speaker Preview Room, at least 1 hour before the start of the session. If combining video films with PowerPoint, please make sure to check it in the session hall where your lecture is taking place during a coffee or lunch break prior to your session, at least 30 minutes before the start of the session. Please note: You cannot use your own personal laptops for the presentation, only the computers available at the Preview room. E-Poster Presentations E-posters will be available for viewing throughout the Symposium in the exhibition area. ISOPT Symposium Secretariat Paragon Conventions 18, Avenue Louis-Casai, 1209 Geneva, Switzerland Tel: +41 22 5330 948, Email: [email protected], Web: www.isopt.net 5 10th ISOPTClinical Reception & Refreshments Welcome Reception 18:00 – Thursday, 7 March All participants are invited to the Welcome Reception at the exhibition area Coffee & Refreshments Sponsored by Coffee will be served in the exhibition area at the times indicated in the Scientific Program Lunch Sessions Lunchboxes will be provided during the sponsored lunch sessions: Friday, March 8th – Sponsored by Saturday, March 9th – Sponsored by 6 The International Symposium on Ocular Pharmacology and Therapeutics March 7-10, 2013, Paris, France Sponsors & Exhibitors Sponsors Exhibitors 7 10th ISOPTClinical Sponsors & Exhibitors Santen Mayumi Fujino 3-9-19 Shimoshinjo, Higashiyodogawa-ku, Osaka 533-8651 Japan Tel: 81-6-6321-7172 Fax: 81-6-6321-7256 Email: [email protected] Website: www.santen.com Santen, one of the oldest ophthalmic pharmaceutical companies in the world, is Japan’s pioneer and leader in ophthalmic pharmaceuticals. Today, we at Santen are focusing our research and development efforts on glaucoma, retinal, and corneal disorders. We are also accelerating our efforts towards globalization to deliver our products and our message of “A clear vision for life®” to people around the world. Alcon Management SA Avenue Louis Casaï 58 1216 Cointrin Switzerland Tel: 41 59 911 2000 Fax: 41 59 911 3000 Alcon’s surgical portfolio includes technologies and devices for cataract, retinal, refractive and glaucoma surgery, such as the INFINITI® vision system for cataract procedures, the CONSTELLATION® vitreoretinal system for retinal operations, and the AcrySof® family of intraocular lenses (IOLs) to treat cataract and refractive errors like presbyopia and astigmatism. Bayer HealthCare Sunny Yang 1000 PO Box, Montville, NJ 07045 USA Tel: 1-973-305-5167 Email: [email protected] Bayer HealthCare, a subgroup of Bayer AG with annual sales of more than EUR 17.2 billion (2011), is one of the world’s leading, innovative companies in the healthcare and medical products industry and is based in Leverkusen, Germany.
Load more

Recommended publications
  • Dr. Andrea Dziubek, Dr. Edmond Rusjan, Dr. William Thistleton
    Faculty and Staff Publication: Dr. Andrea Dziubek, Dr. Edmond Rusjan, Dr. William Thistleton Pre-Print Citation for Final Published Work: Dziubek, A., Guidoboni, G., Harris, A., Hirani, A. N., Rusjan, E., & Thistleton, W. (2016). Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational model. Biomechanics And Modeling In Mechanobiology, (4), 893. doi:10.1007/s10237-015-0731-8 https://search.proquest.com/docview/1811187248 Biomechanics and Modeling in Mechanobiology manuscript No. (will be inserted by the editor) Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational model Andrea Dziubek · Giovanna Guidoboni · Alon Harris · Anil N. Hirani · Edmond Rusjan · William Thistleton Received: date / Accepted: date Abstract A computational model for retinal hemody- retinal hemodynamics is influenced by the ocular shape namics accounting for ocular curvature is presented. (sphere, oblate spheroid, prolate spheroid and barrel The model combines: (i) a hierarchical Darcy model for are compared) and vascular architecture (four vascular the flow through small arterioles, capillaries and small arcs and a branching vascular tree are compared). The venules in the retinal tissue, where blood vessels of dif- model predictions show that changes in ocular shape ferent size are comprised in different hierarchical levels induce non-uniform alterations of blood pressure and of a porous medium; and (ii) a one-dimensional net- velocity in the retina. In particular, we found that: (i) work model for the blood flow through retinal arteri- the temporal region is affected the least by changes in oles and venules of larger size. The non-planar ocular ocular shape, and (ii) the barrel shape departs the most shape is included by: (i) defining the hierarchical Darcy from the hemispherical reference geometry in terms of flow model on a two-dimensional curved surface embed- associated pressure and velocity distributions in the ded in the three-dimensional space; and (ii) mapping retinal microvasculature.
    [Show full text]
  • Eugene and Marilyn Glick Eye Institute Ophthalmology Update
    Indiana University School of Medicine Eugene and Marilyn Glick Eye Institute Ophthalmology Update Department of Ophthalmology Spring 2013 Research team commits to Glick Eye Institute Vision research at the Eugene and researcher, Maria Grant, M.D., will Translational Research in the Marilyn Glick Eye Institute will receive be the first to hold the new Marilyn K. Department of Ophthalmology at a double boost when husband- Glick Senior Chair. They will join the the University of Florida and holds and-wife research scientists from department on July 1. professorships in ophthalmology; the University of Florida join the physiology and functional genomics; Department of Ophthalmology at the Dr. Boulton is currently director medicine; and psychiatry. Her Indiana University School of Medicine of research and professor in the research focuses on understanding this year. Department of Anatomy and Cell and repairing the damage to blood Biology at the University of Florida. vessels in the eye as a result of Michael Boulton, Ph.D., has been His research has focused on age- diabetes. appointed as the first director of related changes in the retina and basic science research and will hold retinal neovascularization. “We are thrilled to welcome Drs. the Merrill Grayson Senior Chair in Boulton and Grant,” said Louis Ophthalmology; his wife and fellow Dr. Grant is currently director of B. Cantor, M.D., Chairman of the (Continued on page 10) Teen is one of first in Indiana to Read about faculty research, new Department of Ophthalmology fac- participate in an intraocular lens grant awards, publications and ulty travel to Zambia and China implant study.
    [Show full text]
  • Cme Reviewarticle
    Volume 58, Number 2 OBSTETRICAL AND GYNECOLOGICAL SURVEY Copyright © 2003 by Lippincott Williams & Wilkins, Inc. CME REVIEWARTICLE 5 CHIEF EDITOR’S NOTE: This article is part of a series of continuing education activities in this Journal through which a total of 36 AMA/PRA category 1 credit hours can be earned in 2003. Instructions for how CME credits can be earned appear on the last page of the Table of Contents. Ocular Changes in Pregnancy Robert B. Dinn, BS,* Alon Harris, MSc, PhD† and Peter S. Marcus, MD‡ *Fourth Year Medical Student, Indiana University School of Medicine; †Professor, Glaucoma Research and Diagnostic Center, Departments of Ophthalmology and Physiology, Indiana University School of Medicine; and ‡Assistant Clinical Professor, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana Visual changes in pregnancy are common, and many are specifically associated with the preg- nancy itself. Serous retinal detachments and blindness occur more frequently during preeclampsia and often subside postpartum. Pregnant women are at increased risk for the progression of preexisting proliferative diabetic retinopathy, and diabetic women should see an ophthalmologist before pregnancy or early in the first trimester. The results of refractive eye surgery before, during, or immediately after pregnancy are unpredictable, and refractive surgery should be postponed until there is a stable postpartum refraction. A decreased tolerance to contact lenses also is common during pregnancy; therefore, it is advisable to fit contact lenses postpartum. Furthermore, preg- nancy is associated with a decreased intraocular pressure in healthy eyes, and the effects of glaucoma medications on the fetus and breast-fed infant are largely unknown.
    [Show full text]
  • Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment
    Journal of Ophthalmology Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment Guest Editors: Antonio Leccisotti, Ioannis M. Aslanides, Johnny E. Moore, and Sunil Shah Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment Journal of Ophthalmology Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment Guest Editors: Antonio Leccisotti, Ioannis M. Aslanides, Johnny E. Moore, and Sunil Shah Copyright © 2012 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Journal of Ophthalmology.” All articles are open access articles distributed under the Creative Com- mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Usha P. Andley, USA Alon Harris, USA Neville Osborne, UK Susanne Binder, Austria Pierre Lachapelle, Canada Cynthia Owsley, USA Anthony J. Bron, UK Andrew G. Lee, USA Mansoor Sarfarazi, USA Chi-Chao Chan, USA C. Kai-shun Leung, Hong Kong Naj Sharif, USA David K. Coats, USA Edward Manche, USA Torben Lykke Sørensen, Denmark Lucian Del Priore, USA M. Mochizuki, Japan G. L. Spaeth, USA Eric Eggenberger, USA Lawrence S. Morse, USA Denis Wakefield, Australia Michel Eid Farah, Brazil Darius M. Moshfeghi, USA David A. Wilkie, USA Ian Grierson, UK Kristina Narfstrom,¨ USA Terri L. Young, USA Contents Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment, Antonio Leccisotti, Ioannis M. Aslanides, Johnny E. Moore, and Sunil Shah Volume
    [Show full text]
  • Dynamic Assessment of the Tear Film Muco-Aqueous and Lipid Layers Using a Novel Tear Film Imager (TFI)
    Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI) Fani Segev 1, 2, Noa Geffen 1, 2, Anat Galor 3, 4, Yoel Cohen 5, Raanan Gefen 5, Avner Belkin 1, Yoel Arieli 5, 6, Shlomi Epshtein 5, Anat Oren 2, Alon Harris 7 1. Ophthalmology, Meir Medical Center, Kfar Sava, Israel. 2. Department of Ophthalmology - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. Ophthalmology, Miami VA Medical Center, Miami, Florida, USA [email protected]. 4. Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA. 5. R&D department, AdOM Advanced Optical Technologies, Lod, Israel. 6. Department of Applied Physics, The Jerusalem College of Technology, Jerusalem, Israel. 7. Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA. ABSTRACT Purpose The objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers. Methods Prospective pilot case series of individuals with and without dry eye (DE). Two sequential images were obtained with the TFI. Measurements were assessed for reproducibility and compared with clinically derived DE metrics. Individuals were grouped into DE categories based on signs of DE. Results 49 patients participated in the study with a mean age of 58.8 years (SD 15.9) and a female majority (69%). Reproducibility of the muco-aqueous layer thickness (MALT) was excellent (r=0.88). MALT measurements significantly correlated with the Schirmer score (r=0.31). Lipid break up time (LBUT) as measured by the TFI significantly correlated with the clinical measure of tear break up time (TBUT) (r=0.73).
    [Show full text]
  • Differences in Ocular Blood Flow Between People of African And
    DIFFERENCES IN OCULAR BLOOD FLOW BETWEEN PEOPLE OF AFRICAN AND EUROPEAN DESCENT WITH HEALTHY EYES Betül Kaskan, MD, Koosha Ramezani, MD, Alon Harris, PhD, Brent Siesky, PhD Carine Olinde, Darrell WuDunn, MD, PhD, Jennifer Eikenberry, MD, Leslie A Tobe, MD, Lyne Racette, PhD Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, USA Correspondence to: Lyne Racette, PhD Eugene and Marilyn Glick Eye Institute Department of Ophthalmology Indiana University School of Medicine 1160 W Michigan Street Indianapolis, IN, 46202 Phone: 317-274-1226 Fax: 317-274-8992 Email: [email protected] This study was supported in part by: Biomedical Research Grant from Indiana University School of Medicine (LR); Indiana University–Purdue University Indianapolis Enhanced Mentoring Program with Opportunities for Ways to Excel in Research (EMPOWER) award (LR); and by an unrestricted grant from Research to Prevent Blindness. _________________________________________________________________________________ This is the author's manuscript of the article published in final edited form as: Kaskan, B., Ramezani, K., Harris, A., Siesky, B., Olinde, C., WuDunn, D., … Racette, L. (2016). Differences in Ocular Blood Flow Between People of African and European Descent With Healthy Eyes: Journal of Glaucoma, 25(9), 709– 715. https://doi.org/10.1097/IJG.0000000000000509 ABSTRACT Purpose: To investigate differences in ocular blood flow between people of African (AD) and European descent (ED) with healthy eyes. Methods: Retrobulbar and retinal capillary blood flow was assessed in one eye of 58 participants (24 AD, 34 ED) with healthy eyes with systemic blood pressure lower than 140/90. Retrobulbar blood flow was measured in the ophthalmic artery (OA), central retinal artery (CRA), nasal (NPCA) and temporal posterior ciliary arteries (TPCA).
    [Show full text]
  • Synthesis and Release of Docosahexaenoic Acid by the RPE
    REPORTS Synthesis and Release of lthough gene mutations for photoreceptor-specific pro- Ateins are generally considered the primary causative factor Docosahexaenoic Acid by the for retinitis pigmentosa, abnormalities in systemic levels of essential long-chain polyunsaturated fatty acids, particularly RPE Cells of prcd-Affected Dogs docosahexaenoic acid (DHA, 22:6n-3), frequently have been Huiming Chen,1,2,3 Jharna Ray,4 reported to be associated with various forms of retinitis pig- 4 4 mentosa in humans. Dogs with progressive rod-cone degener- Virginia Scarpino, Gregory M. Acland, ation (prcd) have reduced DHA levels in the plasma,1 similar to 4 Gustavo D. Aguirre, and the findings in humans with retinitis pigmentosa, and also have Robert E. Anderson1,2,3,5,6 lower DHA levels (approximately 20%) in their rod photore- ceptor outer segments (ROS).2 Although ROS DHA levels in PURPOSE. Dogs affected with progressive rod-cone degen- humans with retinitis pigmentosa have not yet been examined, eration (prcd) have reduced levels of docosahexaenoic pronounced reduction in DHA levels has been observed in the acid (DHA, 22:6n-3) in their plasma and rod photorecep- sperm (the only other body fluid or tissue in the body, besides tor outer segments (ROS). Dietary supplementation of retina and brain, that is enriched in DHA) of male patients 3 DHA has failed to increase the ROS DHA levels to that of affected with retinitis pigmentosa. Thus, the prcd-affected unaffected control dogs. The present study was under- dogs are an excellent animal model for the human disease to taken to test the hypothesis that prcd-affected dogs have a study the mechanisms underlying the lower DHA phenotype and its cause-and-effect relationship with the disease process.
    [Show full text]
  • Automatic Retinal Oximetry
    Automatic Retinal Oximetry Sveinn Hakon Hardarson,1 Alon Harris,2 Robert Arnar Karlsson,3 Gisli Hreinn Halldorsson,3 Larry Kagemann,2,4 Ehud Rechtman,2 Gunnar Ma´r Zoega,1 Thor Eysteinsson,1 Jon Atli Benediktsson,3 Adalbjorn Thorsteinsson,5 Peter Koch Jensen,6 James Beach,7 and Einar Stefa´nsson1 PURPOSE. To measure hemoglobin oxygen saturation (SO2)in noninvasive device to measure retinal oxygen levels is retinal vessels and to test the reproducibility and sensitivity of Aneeded for the study of the role of oxygen levels in human an automatic spectrophotometric oximeter. retinopathy and glaucoma. Spectrophotometric measurements METHODS. Specialized software automatically identifies the ret- of hemoglobin oxygen saturation in human retinal blood ves- 1 inal blood vessels on fundus images, which are obtained with sels was initiated by Hickam et al. in the 1960s but has still not four different wavelengths of light. The software calculates been mastered as a reliable and useful clinical or research tool. optical density ratios (ODRs) for each vessel. The reproducibil- During the past 7 years, we have built on the work of Beach et ity was evaluated by analyzing five repeated measurements of al.,2 Delori,3 and others4 to develop a noninvasive automatic the same vessels. A linear relationship between SO2 and ODR retinal oximeter, which we hope will allow studies of human was assumed and a linear model derived. After calibration, retinal and optic nerve disease in research and clinical settings. reproducibility and sensitivity were calculated in terms of SO2. We report the sensitivity and reproducibility of this device in Systemic hyperoxia (n ϭ 16) was induced in healthy volun- human studies.
    [Show full text]
  • Steven M. Podos, MD Symposium and Lecture Innovations in Ophthalmology
    VIRTUAL Tenth Annual Steven M. Podos, MD Symposium and Lecture Innovations in Ophthalmology Friday, June 4, 2021 10am - 5pm EST 7am - 2pm PST Internet Livestream Course Directors Paul A. Sidoti, MD James C. Tsai, MD Provided by Department of Ophthalmology Icahn School of Medicine at Mount Sinai New York Eye and Ear Infirmary of Mount Sinai Program 10am - 5pm EST 7am - 2pm PST Time Topics Speaker(s) 10:00 Virtual Welcome & Introduction Paul A. Sidoti, MD & James C. Tsai, MD 10:03 PEDIATRIC /GLOBAL HEALTH SECTION Moderator: Tamiesha Frempong, MD, MPH 10:03 Introduction Tamiesha Frempong, MD, MPH 10:04 Walking Together: Research and Partnerships to Optimize Global Health Rachel Vreeman, MD, MS 10:16 Lessons Learned from the Infant Aphakia Treatment Study Deborah K. Vanderveen, MD 10:28 Glaucoma Drainage Devices in Pediatric Patients Erin K. Walsh, MD 10:40 Glaucoma Following Cataract Surgery in Pediatric Patients Deborah K. Vanderveen, MD 10:52 Ethical Considerations for Global Health Engagement Renee Bischoff, MPH 11:04 Live Question & Answer Faculty Group 11:14 Tribute to Oscar Candia, MD John Danias, MD, PhD 11:24 MID-AM BREAK 11:34 RETINA SECTION Moderator: Robin N. Ginsburg, MD 11:35 Seldom-told Tales from a Professional Life in Clinical Trials Stuart L. Fine, MD 11:47 Treatment of Central Retinal Artery Occlusion with Intra-Arterial tPA Gareth Lema, MD, PhD 11:59 Fixing Retinal Detachments: A novel group of evaporative retinal tamponades Avnish Deobhakta, MD 12:11 Live Question & Answer Faculty Group 12:25 PODOS LECTURE 12:25 Introduction: 10th Annual Steven M.
    [Show full text]
  • Mathematical Modeling and Glaucoma: the Need for an Individualized Approach to Risk Assessment
    © Journal for Modeling in Ophthalmology 2016; 1:6-20 Review article Mathematical modeling and glaucoma: the need for an individualized approach to risk assessment Alice Chandra Verticchio Vercellin1,2, Alon Harris1, Jareau Vance Cordell1, Thai Do1, James Moroney3, Aditya Belamkar1, Brent Siesky1 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Michigan State University School of Medicine, Grand Rapids, MI, USA Abstract Primary open-angle glaucoma is a chronic optic neuropathy characterized by retinal ganglion cell loss and subsequent visual field impairment. Elevated intraocular pressure remains the only treatable and modifiable risk factor and vascular impairment has been demonstrated in glaucomatous patients. New research has uncovered varying and often contradictory data suggesting more than just a casual correlation with ethnicity, diabetes, gender, obesity and age. Little is known about each variables’ contribution to the etiology of glaucoma and how their presence or absence with other risk factors potentiate or reduce an individual’s overall risk. The realization that glaucoma is more than a simple, binary disease necessitates a next-generation mathematical model with the capability to integrate individual patient characteristics and clinical risk factors to predict its formation and progression. Key words: blood flow, disease progression, mathematical modeling, primary open-angle glaucoma, risk factors Correspondence: Alon Harris, MS, PhD, FARVO, Director of Clinical Research, Lois Letzter Professor of Ophthalmology, Professor of Cellular and Integrative Physiology, Department of Ophthalmology, Indiana University School of Medicine, 1160 West Michigan Street, India- napolis, IN 46202, USA. E-mail: [email protected] Mathematical modeling and glaucoma 7 1.
    [Show full text]
  • And Cautioned That a Larger Series Is Needed Before One Can Comment on the True Incidence of Ocular Motility Dysfunction Followi
    Correspondence 1014 and cautioned that a larger series is needed before one Although we agree with the authors’ suggestion that can comment on the true incidence of ocular motility the eccentric macular hole probably results ‘from dysfunction following this complication. Therefore, it excessive manipulation,’ we believe that the culprit is not may be misleading to conclude that ‘the migrating necessarily the direct iatrogenic insult alone. We concur encircling band is not usually linked to ocular motility with their opinion that ‘outer retinal degenerative changes disturbance’. We suggest that it is important to consider may increase the risk of eccentric macular hole migration of encircling elements in the differential formation.’1 Concomitant predisposing degenerative diagnosis of diplopia in patients with previous scleral weaknesses as in the presence of ‘extensive drusen’1 or buckling procedures to ensure that important clinical myopic chorioretinal degeneration (as in our case) as well signs are not overlooked in examination. as weakening of the glial structure of the retina caused by decapitation of the Muller cells3 may also play a role in the development of eccentric macular hole. References 1 Kreis AJ, Klainguti G, Bovey EH, Wolfensberger TJ. Transmuscular migration of 240 silicone encircling band. References Eye 2006; 20: 1456–1458. 1 Polkinghorne PJ, Roufail E. Eccentric macular hole formation 2 Seaber JH, Buckley EG. Strabismus after retinal detachment associated with macular hole surgery. Eye 2007; 21: 122–123. surgery: etiology, diagnosis, and treatment. Semin Ophthalmol 2 Rubinstein A, Bates R, Benjamin L, Shaik A. Iatrogenic 1995; 10: 61–73. eccentric full thickness macular holes following vitrectomy 3 Macleod JDA, Morris RJ.
    [Show full text]
  • Eugene and Marilyn Glick Eye Institute Ophthalmology Update
    Indiana University School of Medicine Eugene and Marilyn Glick Eye Institute Ophthalmology Update Department of Ophthalmology Spring 2014 IUSM students in the Department of Ophthalmology are at the forefront of clinical and translational science research projects From learning how drugs work to drugs to treat age related macular have the disease, and to impress understanding why patients don’t degeneration and retinopathy of upon them the importance of always take their medications as prematurity. complying with their prescription prescribed, students at the Eugene regimen. and Marilyn Glick Eye Institute are Lyne Racette, Ph.D., investigates participating in research they hope racial differences in glaucoma and “I speak with each study participant will change peoples’ lives. is studying why some patients are individually to explain open-angle better than others at understanding glaucoma, its risk factors, eye In the lab of Tim Corson, Ph.D., and taking their medications. anatomy, how their prescription Halesha Basavarajappa, a third- drops work and the importance of year Ph.D. student, is working on Working with her is student compliance in order to save their the basics of drug discovery. He’s Elizabeth Eads, who is developing sight,” said Eads, who is completing learning the basic steps of designing an educational intervention to help her master of public health degree at molecules that might become explain glaucoma to patients who IUPUI. Continued on Page 4 Cover image: A pre-retinal vascular Ophthalmology Student Interest Group Meet the new Ophthalmology residents. tuft from a 17-day-old mouse that has (OSIG) establishes eye clinic within IUSM Read more Page 5.
    [Show full text]