DOCSLIB.ORG

Eugene and Marilyn Glick Eye Institute Ophthalmology Update

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Eugene and Marilyn Glick Eye Institute Ophthalmology Update Indiana University School of Medicine Eugene and Marilyn Glick Eye Institute Ophthalmology Update Department of Ophthalmology Spring 2014 IUSM students in the Department of Ophthalmology are at the forefront of clinical and translational science research projects From learning how drugs work to drugs to treat age related macular have the disease, and to impress understanding why patients don’t degeneration and retinopathy of upon them the importance of always take their medications as prematurity. complying with their prescription prescribed, students at the Eugene regimen. and Marilyn Glick Eye Institute are Lyne Racette, Ph.D., investigates participating in research they hope racial differences in glaucoma and “I speak with each study participant will change peoples’ lives. is studying why some patients are individually to explain open-angle better than others at understanding glaucoma, its risk factors, eye In the lab of Tim Corson, Ph.D., and taking their medications. anatomy, how their prescription Halesha Basavarajappa, a third- drops work and the importance of year Ph.D. student, is working on Working with her is student compliance in order to save their the basics of drug discovery. He’s Elizabeth Eads, who is developing sight,” said Eads, who is completing learning the basic steps of designing an educational intervention to help her master of public health degree at molecules that might become explain glaucoma to patients who IUPUI. Continued on Page 4 Cover image: A pre-retinal vascular Ophthalmology Student Interest Group Meet the new Ophthalmology residents. tuft from a 17-day-old mouse that has (OSIG) establishes eye clinic within IUSM Read more Page 5. gone through a model of retinopathy student outreach clinic. of prematurity (from the lab of Maria Faculty news, notes and honors. Grant, M.D.). Read more Page 3. Read more Pages 6-7. From the Chairman I continue to be impressed by the faculty, residents and fellows, students Philanthropic support is necessary to and staff in the Department of Ophthalmology. The two students you read accelerate vision research. To learn how about in our cover story are among dozens of bright, talented young people you can make a tax-deductible gift to who are working here to achieve a common goal - saving sight. From benefit the Eugene and Marilyn Glick Eye our clinical initiatives to the basic science and translational research that Institute, please contact: occurs at the Glick Eye Institute, and in our research labs across the IU Linda E. Cantor, J.D. School of Medicine campus, real strides are being made toward that goal. Director of Development Eugene and Marilyn Glick Eye Institute Our next generation of ophthalmologists - the medical students who Indiana University School of Medicine are members of the Ophthalmology Student Interest Group - have [email protected] laid the foundation for a permanent eye clinic at a School of Medicine neighborhood health clinic in a church basement not far from downtown Phone: 317.274.3602 or Indianapolis. These promising young students, who will be our eye care 800.643.6975 providers in the future, devote their time to provide free screenings to an Donations may be mailed to: underserved population. IU School of Medicine You can read about them on Page 3. c/o IU Foundation PO Box 6460 On campus we are experiencing change as our faculty practice prepares Indianapolis, IN 46206-6460 to transition into the Indiana University Health Physicians practice. We are receiving expert guidance from Brian Kremer, vice president of Surgical Services at IUHP as he and his team interview all faculty and staff to Gifts to the Glick Eye Institute determine how new roles will be assigned with the transition. Our goal is to provide seamless care for our patients by aligning with IUHP. Donors who wish to make a memorial gift, or a donation to honor someone, may do so at any time. There are several Louis Cantor, M.D. funds available for support, including the building fund, several research funds or an endowment in memory of Eugene and Marilyn Glick. All options are listed on our website, www.glick.iu.edu, where dona- tions also can be made. If you have questions about how to me- Chair and Professor of Ophthalmology morialize or honor a friend or loved one Jay C. and Lucile L. Kahn Professor of Glaucoma with a gift to the Eugene and Marilyn Glick Research and Education Eye Institute, please contact Linda Cantor Director, Glaucoma Service at (317) 274-3602. Eugene and Marilyn Glick Eye Institute Indiana University School of Medicine Online donations may be made through Department of Ophthalmology the Eugene and Marilyn Glick Eye Insti- tute website at: www.glick.iu.edu 2 Spring 2014 OSIG establishes eye clinic within IUSM student outreach clinic The Ophthalmology Student Interest approached OSIG with the idea to included Dr. Yung and Amy Waddell, Group has established an eye clinic start an eye clinic last summer. OSIG M.D., and residents Sally Primus, for the IU School of Medicine’s quickly began working and with the M.D., and Evan Dunn, M.D. More Student Outreach Clinic. help of the IU School of Optometry, a than 20 patients were screened with slit-lamp and phoropter were donated 10 individuals receiving prescriptions The Student Outreach Clinic is a free to the clinic. for free glasses. Medical students clinic based at the Neighborhood volunteer to staff the clinic and work Fellowship Church on the near east Next, senior medical student Ana to triage patients, test visual acuity, side of Indianapolis. According to a Pearson applied for and received a auto-refract, use the tonopen and 2007 community assessment, there $12,000 grant from the IU Woman’s take fundus photos. are roughly 15,000 homes in the Philanthropy Council to purchase community with 50 percent or more a non-mydriatic fundus camera. Faculty oversee fundus photos, check of the residents living at or below the Prevent Blindness Indiana also for pathology and counsel patients poverty level. donated equipment to OSIG including should they need follow-up care. a large auto-refractor, multiple visual Residents work at the slit-lamp and Many IUSOC clinic patients field machines, and more. Chi Wah refract patients who need glasses. report unmet health needs for (Rudy) Yung, M.D., OSIG faculty During the most recent clinic, 18 a variety of reasons, including advisor, secured necessary clinic medical students volunteered to work cost, lack of transportation or items such as a retinascope and at the clinic. First and second year lack of a primary care provider. occluders, and mapped out clinic medical students learned how to use Additionally many report a fear of logistics with students. the tonopen and check visual acuity. the medical community. Poverty and This clinic helps a population in need unemployment add to the number With a fully equipped clinic, OSIG while introducing medical students of uninsured residents. The IUSOC hopes to screen for preventable to ophthalmology. Medical students helps close the healthcare gap in disease including glaucoma and with an interest in ophthalmology this community by coordinating a diabetic retinopathy and provide also can practice refraction under the nonthreatening medical presence free glasses prescriptions. Senior supervision of a resident and faculty right in the neighborhood. medical student Andrea Wenzel member. worked to establish a partnership The IUSOC functions as a student with OneSight, a large philanthropic Although the clinic is in its first run clinic and provides free medical organization that provides free year, OSIG members believe it has care along with other services from glasses through participating retailers tremendous potential to give back partners including the IU School including LensCrafters. Now, patients to the community while fostering an of Dentistry, School of Law, social at the IUSOC Eye Clinic can receive environment for learning between work, physical therapy, occupational a free screening eye exam, glasses medical students, residents and therapy and the Butler University prescription and free glasses at faculty. Interested volunteers can School of Pharmacy. Starting this LensCrafters. contact Dr. Yung at [email protected]. year, the IUSOC now offers vision Faculty volunteers are needed for the services thanks to the work of the IU To provide glasses prescriptions, last Saturday of each month. School of Medicine Ophthalmology OSIG needs one faculty and resident Student Interest Group or OSIG. volunteer each month. At a recent -- submitted by Andrea Wenzel Student leaders from the IUSOC clinic in March, faculty members Wenzel selected as Plater Civic Engagement Medallion Award winner Andrea Wenzel, a student at the IU School of Medicine, Ph.D., in his lab. She was recently featured as the will be one of the recipients of the 2014 Plater Civic Student Spotlight in the weekly IU School of Medicine Engagement Medallion Award. e-newsletter INScope. Andrea is active in the Ophthalmology Student “I nominated Andrea for the 2014 Plater Civic Interest Group, providing vision screenings for at-risk Engagement Medallion Award and I am glad to learn that communities and working in research at the Glick Eye she has been chosen as one of the recipients,” said Chi Institute, home of the Department of Ophthalmology. Wah (Rudy) Yung, M.D., faculty advisor for OSIG. “This honor reflects her exemplary commitment to serve the She worked for former faculty member Brian Samuels, local community with vision screenings and as president M.D., Ph.D., in his lab and also worked for Tim Corson, of the student group.” Spring 2014 3 IUSM students at the forefront of clinical and translational science research projects Continiued from Page 1 since last fall, as part of her internship in the master’s in public health program. “My background in science, my background in working with patients with a local optometrist and my studies on vulnerable populations all come together when I am at the Glick Eye Institute,” Eads said.
Load more

Recommended publications
  • Program & Abstracts
    The International Symposium on Ocular Pharmacology and Therapeutics www.isopt.net 10th ISOPTClinical March 7-10, 2013, Paris, France Program & Abstracts Retina Glaucoma Inflammation & Infection Basic External Eye DevelopmentDrug Science Diseases ISOPT is Celebrating its 10th Anniversary 10th ISOPTClinical Contents Welcome . Committees. General Information. Reception & Refreshments. Sponsors & Exhibitors . Scientific Program Thursday, March 7 . Friday, March 8 . Saturday, March 9. Sunday, March 10 . E-Posters . Abstracts . Index of Authors . 2 The International Symposium on Ocular Pharmacology and Therapeutics March 7-10, 2013, Paris, France Dear Colleague, ISOPT is Celebrating its 10th Anniversary! Over the years ISOPT has become a place for formal updates of medical ophthalmology and drug utilization combined with informal meetings of clinicians and drug developers. ISOPT’s vision is to increase knowledge and awareness of drug usage in ophthalmology, reflecting innovations and their utilization in practice. ISOPT’s vision will be reflected in the following missions: • Share treatment algorithms in major ophthalmic indications. • Implement data from clinical studies for daily practice • Facilitate innovation – connecting innovators with practitioners ISOPT offers a relevant and updated scientific program in a relaxed atmosphere leading to direct interactions of its delegates. We welcome you in Paris, and invite you to share experiences and insights, whether your field of interest is in retinal diseases, inflammation, cornea and external diseases, glaucoma or basic science. Ron Neumann, MD Sara Krupsky, MD Symposium Chairpersons 3 10th ISOPTClinical Committees Chairpersons Special Program Advisor S. Krupsky, Israel B.D. Kuppermann, USA R. Neumann, Israel Scientific Advisory Board P.A. Asbell, USA A. Das, USA P. Kaufman, USA H. Reitsamer, Austria E.K.
    [Show full text]
  • Dr. Andrea Dziubek, Dr. Edmond Rusjan, Dr. William Thistleton
    Faculty and Staff Publication: Dr. Andrea Dziubek, Dr. Edmond Rusjan, Dr. William Thistleton Pre-Print Citation for Final Published Work: Dziubek, A., Guidoboni, G., Harris, A., Hirani, A. N., Rusjan, E., & Thistleton, W. (2016). Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational model. Biomechanics And Modeling In Mechanobiology, (4), 893. doi:10.1007/s10237-015-0731-8 https://search.proquest.com/docview/1811187248 Biomechanics and Modeling in Mechanobiology manuscript No. (will be inserted by the editor) Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational model Andrea Dziubek · Giovanna Guidoboni · Alon Harris · Anil N. Hirani · Edmond Rusjan · William Thistleton Received: date / Accepted: date Abstract A computational model for retinal hemody- retinal hemodynamics is influenced by the ocular shape namics accounting for ocular curvature is presented. (sphere, oblate spheroid, prolate spheroid and barrel The model combines: (i) a hierarchical Darcy model for are compared) and vascular architecture (four vascular the flow through small arterioles, capillaries and small arcs and a branching vascular tree are compared). The venules in the retinal tissue, where blood vessels of dif- model predictions show that changes in ocular shape ferent size are comprised in different hierarchical levels induce non-uniform alterations of blood pressure and of a porous medium; and (ii) a one-dimensional net- velocity in the retina. In particular, we found that: (i) work model for the blood flow through retinal arteri- the temporal region is affected the least by changes in oles and venules of larger size. The non-planar ocular ocular shape, and (ii) the barrel shape departs the most shape is included by: (i) defining the hierarchical Darcy from the hemispherical reference geometry in terms of flow model on a two-dimensional curved surface embed- associated pressure and velocity distributions in the ded in the three-dimensional space; and (ii) mapping retinal microvasculature.
    [Show full text]
  • Eugene and Marilyn Glick Eye Institute Ophthalmology Update
    Indiana University School of Medicine Eugene and Marilyn Glick Eye Institute Ophthalmology Update Department of Ophthalmology Spring 2013 Research team commits to Glick Eye Institute Vision research at the Eugene and researcher, Maria Grant, M.D., will Translational Research in the Marilyn Glick Eye Institute will receive be the first to hold the new Marilyn K. Department of Ophthalmology at a double boost when husband- Glick Senior Chair. They will join the the University of Florida and holds and-wife research scientists from department on July 1. professorships in ophthalmology; the University of Florida join the physiology and functional genomics; Department of Ophthalmology at the Dr. Boulton is currently director medicine; and psychiatry. Her Indiana University School of Medicine of research and professor in the research focuses on understanding this year. Department of Anatomy and Cell and repairing the damage to blood Biology at the University of Florida. vessels in the eye as a result of Michael Boulton, Ph.D., has been His research has focused on age- diabetes. appointed as the first director of related changes in the retina and basic science research and will hold retinal neovascularization. “We are thrilled to welcome Drs. the Merrill Grayson Senior Chair in Boulton and Grant,” said Louis Ophthalmology; his wife and fellow Dr. Grant is currently director of B. Cantor, M.D., Chairman of the (Continued on page 10) Teen is one of first in Indiana to Read about faculty research, new Department of Ophthalmology fac- participate in an intraocular lens grant awards, publications and ulty travel to Zambia and China implant study.
    [Show full text]
  • Cme Reviewarticle
    Volume 58, Number 2 OBSTETRICAL AND GYNECOLOGICAL SURVEY Copyright © 2003 by Lippincott Williams & Wilkins, Inc. CME REVIEWARTICLE 5 CHIEF EDITOR’S NOTE: This article is part of a series of continuing education activities in this Journal through which a total of 36 AMA/PRA category 1 credit hours can be earned in 2003. Instructions for how CME credits can be earned appear on the last page of the Table of Contents. Ocular Changes in Pregnancy Robert B. Dinn, BS,* Alon Harris, MSc, PhD† and Peter S. Marcus, MD‡ *Fourth Year Medical Student, Indiana University School of Medicine; †Professor, Glaucoma Research and Diagnostic Center, Departments of Ophthalmology and Physiology, Indiana University School of Medicine; and ‡Assistant Clinical Professor, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana Visual changes in pregnancy are common, and many are specifically associated with the preg- nancy itself. Serous retinal detachments and blindness occur more frequently during preeclampsia and often subside postpartum. Pregnant women are at increased risk for the progression of preexisting proliferative diabetic retinopathy, and diabetic women should see an ophthalmologist before pregnancy or early in the first trimester. The results of refractive eye surgery before, during, or immediately after pregnancy are unpredictable, and refractive surgery should be postponed until there is a stable postpartum refraction. A decreased tolerance to contact lenses also is common during pregnancy; therefore, it is advisable to fit contact lenses postpartum. Furthermore, preg- nancy is associated with a decreased intraocular pressure in healthy eyes, and the effects of glaucoma medications on the fetus and breast-fed infant are largely unknown.
    [Show full text]
  • Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment
    Journal of Ophthalmology Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment Guest Editors: Antonio Leccisotti, Ioannis M. Aslanides, Johnny E. Moore, and Sunil Shah Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment Journal of Ophthalmology Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment Guest Editors: Antonio Leccisotti, Ioannis M. Aslanides, Johnny E. Moore, and Sunil Shah Copyright © 2012 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Journal of Ophthalmology.” All articles are open access articles distributed under the Creative Com- mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Usha P. Andley, USA Alon Harris, USA Neville Osborne, UK Susanne Binder, Austria Pierre Lachapelle, Canada Cynthia Owsley, USA Anthony J. Bron, UK Andrew G. Lee, USA Mansoor Sarfarazi, USA Chi-Chao Chan, USA C. Kai-shun Leung, Hong Kong Naj Sharif, USA David K. Coats, USA Edward Manche, USA Torben Lykke Sørensen, Denmark Lucian Del Priore, USA M. Mochizuki, Japan G. L. Spaeth, USA Eric Eggenberger, USA Lawrence S. Morse, USA Denis Wakefield, Australia Michel Eid Farah, Brazil Darius M. Moshfeghi, USA David A. Wilkie, USA Ian Grierson, UK Kristina Narfstrom,¨ USA Terri L. Young, USA Contents Keratoconus and Keratoectasia: Advancements in Diagnosis and Treatment, Antonio Leccisotti, Ioannis M. Aslanides, Johnny E. Moore, and Sunil Shah Volume
    [Show full text]
  • Dynamic Assessment of the Tear Film Muco-Aqueous and Lipid Layers Using a Novel Tear Film Imager (TFI)
    Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI) Fani Segev 1, 2, Noa Geffen 1, 2, Anat Galor 3, 4, Yoel Cohen 5, Raanan Gefen 5, Avner Belkin 1, Yoel Arieli 5, 6, Shlomi Epshtein 5, Anat Oren 2, Alon Harris 7 1. Ophthalmology, Meir Medical Center, Kfar Sava, Israel. 2. Department of Ophthalmology - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. Ophthalmology, Miami VA Medical Center, Miami, Florida, USA [email protected]. 4. Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA. 5. R&D department, AdOM Advanced Optical Technologies, Lod, Israel. 6. Department of Applied Physics, The Jerusalem College of Technology, Jerusalem, Israel. 7. Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA. ABSTRACT Purpose The objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers. Methods Prospective pilot case series of individuals with and without dry eye (DE). Two sequential images were obtained with the TFI. Measurements were assessed for reproducibility and compared with clinically derived DE metrics. Individuals were grouped into DE categories based on signs of DE. Results 49 patients participated in the study with a mean age of 58.8 years (SD 15.9) and a female majority (69%). Reproducibility of the muco-aqueous layer thickness (MALT) was excellent (r=0.88). MALT measurements significantly correlated with the Schirmer score (r=0.31). Lipid break up time (LBUT) as measured by the TFI significantly correlated with the clinical measure of tear break up time (TBUT) (r=0.73).
    [Show full text]
  • Differences in Ocular Blood Flow Between People of African And
    DIFFERENCES IN OCULAR BLOOD FLOW BETWEEN PEOPLE OF AFRICAN AND EUROPEAN DESCENT WITH HEALTHY EYES Betül Kaskan, MD, Koosha Ramezani, MD, Alon Harris, PhD, Brent Siesky, PhD Carine Olinde, Darrell WuDunn, MD, PhD, Jennifer Eikenberry, MD, Leslie A Tobe, MD, Lyne Racette, PhD Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, USA Correspondence to: Lyne Racette, PhD Eugene and Marilyn Glick Eye Institute Department of Ophthalmology Indiana University School of Medicine 1160 W Michigan Street Indianapolis, IN, 46202 Phone: 317-274-1226 Fax: 317-274-8992 Email: [email protected] This study was supported in part by: Biomedical Research Grant from Indiana University School of Medicine (LR); Indiana University–Purdue University Indianapolis Enhanced Mentoring Program with Opportunities for Ways to Excel in Research (EMPOWER) award (LR); and by an unrestricted grant from Research to Prevent Blindness. _________________________________________________________________________________ This is the author's manuscript of the article published in final edited form as: Kaskan, B., Ramezani, K., Harris, A., Siesky, B., Olinde, C., WuDunn, D., … Racette, L. (2016). Differences in Ocular Blood Flow Between People of African and European Descent With Healthy Eyes: Journal of Glaucoma, 25(9), 709– 715. https://doi.org/10.1097/IJG.0000000000000509 ABSTRACT Purpose: To investigate differences in ocular blood flow between people of African (AD) and European descent (ED) with healthy eyes. Methods: Retrobulbar and retinal capillary blood flow was assessed in one eye of 58 participants (24 AD, 34 ED) with healthy eyes with systemic blood pressure lower than 140/90. Retrobulbar blood flow was measured in the ophthalmic artery (OA), central retinal artery (CRA), nasal (NPCA) and temporal posterior ciliary arteries (TPCA).
    [Show full text]
  • Synthesis and Release of Docosahexaenoic Acid by the RPE
    REPORTS Synthesis and Release of lthough gene mutations for photoreceptor-specific pro- Ateins are generally considered the primary causative factor Docosahexaenoic Acid by the for retinitis pigmentosa, abnormalities in systemic levels of essential long-chain polyunsaturated fatty acids, particularly RPE Cells of prcd-Affected Dogs docosahexaenoic acid (DHA, 22:6n-3), frequently have been Huiming Chen,1,2,3 Jharna Ray,4 reported to be associated with various forms of retinitis pig- 4 4 mentosa in humans. Dogs with progressive rod-cone degener- Virginia Scarpino, Gregory M. Acland, ation (prcd) have reduced DHA levels in the plasma,1 similar to 4 Gustavo D. Aguirre, and the findings in humans with retinitis pigmentosa, and also have Robert E. Anderson1,2,3,5,6 lower DHA levels (approximately 20%) in their rod photore- ceptor outer segments (ROS).2 Although ROS DHA levels in PURPOSE. Dogs affected with progressive rod-cone degen- humans with retinitis pigmentosa have not yet been examined, eration (prcd) have reduced levels of docosahexaenoic pronounced reduction in DHA levels has been observed in the acid (DHA, 22:6n-3) in their plasma and rod photorecep- sperm (the only other body fluid or tissue in the body, besides tor outer segments (ROS). Dietary supplementation of retina and brain, that is enriched in DHA) of male patients 3 DHA has failed to increase the ROS DHA levels to that of affected with retinitis pigmentosa. Thus, the prcd-affected unaffected control dogs. The present study was under- dogs are an excellent animal model for the human disease to taken to test the hypothesis that prcd-affected dogs have a study the mechanisms underlying the lower DHA phenotype and its cause-and-effect relationship with the disease process.
    [Show full text]
  • Automatic Retinal Oximetry
    Automatic Retinal Oximetry Sveinn Hakon Hardarson,1 Alon Harris,2 Robert Arnar Karlsson,3 Gisli Hreinn Halldorsson,3 Larry Kagemann,2,4 Ehud Rechtman,2 Gunnar Ma´r Zoega,1 Thor Eysteinsson,1 Jon Atli Benediktsson,3 Adalbjorn Thorsteinsson,5 Peter Koch Jensen,6 James Beach,7 and Einar Stefa´nsson1 PURPOSE. To measure hemoglobin oxygen saturation (SO2)in noninvasive device to measure retinal oxygen levels is retinal vessels and to test the reproducibility and sensitivity of Aneeded for the study of the role of oxygen levels in human an automatic spectrophotometric oximeter. retinopathy and glaucoma. Spectrophotometric measurements METHODS. Specialized software automatically identifies the ret- of hemoglobin oxygen saturation in human retinal blood ves- 1 inal blood vessels on fundus images, which are obtained with sels was initiated by Hickam et al. in the 1960s but has still not four different wavelengths of light. The software calculates been mastered as a reliable and useful clinical or research tool. optical density ratios (ODRs) for each vessel. The reproducibil- During the past 7 years, we have built on the work of Beach et ity was evaluated by analyzing five repeated measurements of al.,2 Delori,3 and others4 to develop a noninvasive automatic the same vessels. A linear relationship between SO2 and ODR retinal oximeter, which we hope will allow studies of human was assumed and a linear model derived. After calibration, retinal and optic nerve disease in research and clinical settings. reproducibility and sensitivity were calculated in terms of SO2. We report the sensitivity and reproducibility of this device in Systemic hyperoxia (n ϭ 16) was induced in healthy volun- human studies.
    [Show full text]
  • Steven M. Podos, MD Symposium and Lecture Innovations in Ophthalmology
    VIRTUAL Tenth Annual Steven M. Podos, MD Symposium and Lecture Innovations in Ophthalmology Friday, June 4, 2021 10am - 5pm EST 7am - 2pm PST Internet Livestream Course Directors Paul A. Sidoti, MD James C. Tsai, MD Provided by Department of Ophthalmology Icahn School of Medicine at Mount Sinai New York Eye and Ear Infirmary of Mount Sinai Program 10am - 5pm EST 7am - 2pm PST Time Topics Speaker(s) 10:00 Virtual Welcome & Introduction Paul A. Sidoti, MD & James C. Tsai, MD 10:03 PEDIATRIC /GLOBAL HEALTH SECTION Moderator: Tamiesha Frempong, MD, MPH 10:03 Introduction Tamiesha Frempong, MD, MPH 10:04 Walking Together: Research and Partnerships to Optimize Global Health Rachel Vreeman, MD, MS 10:16 Lessons Learned from the Infant Aphakia Treatment Study Deborah K. Vanderveen, MD 10:28 Glaucoma Drainage Devices in Pediatric Patients Erin K. Walsh, MD 10:40 Glaucoma Following Cataract Surgery in Pediatric Patients Deborah K. Vanderveen, MD 10:52 Ethical Considerations for Global Health Engagement Renee Bischoff, MPH 11:04 Live Question & Answer Faculty Group 11:14 Tribute to Oscar Candia, MD John Danias, MD, PhD 11:24 MID-AM BREAK 11:34 RETINA SECTION Moderator: Robin N. Ginsburg, MD 11:35 Seldom-told Tales from a Professional Life in Clinical Trials Stuart L. Fine, MD 11:47 Treatment of Central Retinal Artery Occlusion with Intra-Arterial tPA Gareth Lema, MD, PhD 11:59 Fixing Retinal Detachments: A novel group of evaporative retinal tamponades Avnish Deobhakta, MD 12:11 Live Question & Answer Faculty Group 12:25 PODOS LECTURE 12:25 Introduction: 10th Annual Steven M.
    [Show full text]
  • Mathematical Modeling and Glaucoma: the Need for an Individualized Approach to Risk Assessment
    © Journal for Modeling in Ophthalmology 2016; 1:6-20 Review article Mathematical modeling and glaucoma: the need for an individualized approach to risk assessment Alice Chandra Verticchio Vercellin1,2, Alon Harris1, Jareau Vance Cordell1, Thai Do1, James Moroney3, Aditya Belamkar1, Brent Siesky1 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Michigan State University School of Medicine, Grand Rapids, MI, USA Abstract Primary open-angle glaucoma is a chronic optic neuropathy characterized by retinal ganglion cell loss and subsequent visual field impairment. Elevated intraocular pressure remains the only treatable and modifiable risk factor and vascular impairment has been demonstrated in glaucomatous patients. New research has uncovered varying and often contradictory data suggesting more than just a casual correlation with ethnicity, diabetes, gender, obesity and age. Little is known about each variables’ contribution to the etiology of glaucoma and how their presence or absence with other risk factors potentiate or reduce an individual’s overall risk. The realization that glaucoma is more than a simple, binary disease necessitates a next-generation mathematical model with the capability to integrate individual patient characteristics and clinical risk factors to predict its formation and progression. Key words: blood flow, disease progression, mathematical modeling, primary open-angle glaucoma, risk factors Correspondence: Alon Harris, MS, PhD, FARVO, Director of Clinical Research, Lois Letzter Professor of Ophthalmology, Professor of Cellular and Integrative Physiology, Department of Ophthalmology, Indiana University School of Medicine, 1160 West Michigan Street, India- napolis, IN 46202, USA. E-mail: [email protected] Mathematical modeling and glaucoma 7 1.
    [Show full text]
  • And Cautioned That a Larger Series Is Needed Before One Can Comment on the True Incidence of Ocular Motility Dysfunction Followi
    Correspondence 1014 and cautioned that a larger series is needed before one Although we agree with the authors’ suggestion that can comment on the true incidence of ocular motility the eccentric macular hole probably results ‘from dysfunction following this complication. Therefore, it excessive manipulation,’ we believe that the culprit is not may be misleading to conclude that ‘the migrating necessarily the direct iatrogenic insult alone. We concur encircling band is not usually linked to ocular motility with their opinion that ‘outer retinal degenerative changes disturbance’. We suggest that it is important to consider may increase the risk of eccentric macular hole migration of encircling elements in the differential formation.’1 Concomitant predisposing degenerative diagnosis of diplopia in patients with previous scleral weaknesses as in the presence of ‘extensive drusen’1 or buckling procedures to ensure that important clinical myopic chorioretinal degeneration (as in our case) as well signs are not overlooked in examination. as weakening of the glial structure of the retina caused by decapitation of the Muller cells3 may also play a role in the development of eccentric macular hole. References 1 Kreis AJ, Klainguti G, Bovey EH, Wolfensberger TJ. Transmuscular migration of 240 silicone encircling band. References Eye 2006; 20: 1456–1458. 1 Polkinghorne PJ, Roufail E. Eccentric macular hole formation 2 Seaber JH, Buckley EG. Strabismus after retinal detachment associated with macular hole surgery. Eye 2007; 21: 122–123. surgery: etiology, diagnosis, and treatment. Semin Ophthalmol 2 Rubinstein A, Bates R, Benjamin L, Shaik A. Iatrogenic 1995; 10: 61–73. eccentric full thickness macular holes following vitrectomy 3 Macleod JDA, Morris RJ.
    [Show full text]