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Abstract Book ABSTRACT BOOK 16th ANNUAL US HUPO Conference Novel Proteomic Perspectives on Aging, Cancer and Disease March 8–11, 2020 The Westin Seattle, Seattle Washington, USA 16th Annual US HUPO Conference The Co-chairs would like to express their sincere gratitude to the following sponsors for their generous financial support: PLATINUM SPONSORS ADDITIONAL SUPPORT *Funding for this conference was made possible (in part) by 1R13CA250291-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Bruker at US HUPO timsTOF Pro and PASEF The New Standard for Shotgun Proteomics timsTOF Pro with PASEF technology delivers revolutionary improvements in scan speed, coupled with enhanced specificity and high sensitivity. Near 100% duty cycle using dual TIMS technology Unrivalled MS/MS speed >100Hz Discover more proteins using PASEF Meet the Experts Booth #204 Bruker Lunch Seminar Monday, March 9th, 12:15pm – 1:30pm; Cascade Room #2 diaPASEF: combining improved ion usage efficiency with data independent acquisition to quantify proteomes Dr. Ben Collins, Reader in the School of Biological Sciences at Queen’s University Belfast Building protein interaction networks to understand KRAS lung cancer Dr. Peter Jackson, Professor, Stanford University School of Medicine Register here or at our Booth #204 TIMS-QTOF MS Innovation with Integrity For research use only. Not for use in clinical diagnostic procedures CONFERENCE ORGANIZERS & BOARD OF DIRECTORS 2020 CONFERENCE ORGANIZERS Lan Huang University of California, Irvine Karin Rodland Pacific Northwest National University Birgit Schilling The Buck Institute Judit Villen University of Washington US HUPO BOARD OF DIRECTORS President, Ileana Cristea Secretary, David Arnott Past President, David Muddiman Princeton University Genentech North Carolina State University President, Jennifer Van Eyk Treasurer, Birgit Schilling Cedars-Sinai Medical Center The Buck Institute Ralph Bradshaw Lingjun Li Henry Rodriguez University of California, Irvine University of Wisconsin, Madison National Institutes of Health, Robert Chalkley Joseph Loo National Cancer Institute University of California, San Francisco University of California, Los Angeles Laura Sanchez Joshua Coon Michael MacCoss University of Illinois at Chicago University of Wisconsin, Madison University of Washington Michael Snyder Catherine Costello Robert Moritz Stanford University Boston University Institute for Systems Biology Hanno Steen David Fenyo Alexey Nesvizhskii Harvard University New York University University of Michigan W. Andy Tao Benjamin Garcia Gil Omenn Purdue University Univeristy of Pennsylvania University of Michigan Judit Villen Timothy Griffin Laurie Parker University of Washington University of Minnesota University of Minnesota Olga Vitek Rebekah Gundry Peipei Ping Northeastern University University of Nebraska Medical Center University of California, Los Angeles John Yates Lan Huang Karin Rodland The Scripps Research Institute University of California, Irvine Paific Northwest National Laboratory US HUPO SECRETARIAT www.ConferenceSolutionsInc.com 16th Annual US HUPO 2020 Conference 3 Entering the Digital Age of Mass Spectrometry Shimadzu’s first-of-its-kind MALDImini-1 digital ion trap mass spectrometer fits in a space the size of a piece of paper, allowing installation in places where mass spectrometers could not previously fit. It enables ion trapping up to 70,000 Da and the MS/MS and MS3 functionality of the DIT allows researchers to carry out comprehensive structural analyses with ease. Space-saving lightweight design fits anywhere Fast, simple setup allows for a more convenient workflow Only device capable of MALDI-MSn in this compact size Software allows switching quickly and easily between MS, MS/MS and MS³ modes for seamless analysis Learn more about Shimadzu’s MALDImini-1. Visit us online at www.ssi.shimadzu.com Order consumables and accessories on-line at http://store.shimadzu.com Shimadzu Scientific Instruments Inc., 7102 Riverwood Dr., Columbia, MD 21046, USA Why wait hours for Proteomics results when you can wait minutes? Sometimes a quick answer is needed, complexity isn’t an issue, or large sample cohorts require the highest possible throughput. Explore new horizons in fast proteomics with microflow LC approaches on the TripleTOF® 6600 System. SWATH® Data Dependent Acquisition 1200 1500 900 Acquisition 1800 600 2100 1200 1500 900 300 1800 600 2400 H M S 2100 300 2400 2200 Gradient Length 1492 Proteins Proteins Quantified Identified The SCIEX clinical diagnostic portfolio is For In Vitro Diagnostic Use. Rx Only. Product(s) not available in all countries. For information on availability, please contact your local sales representative or refer to https://sciex.com/diagnostics. All other products are For Research Use Only. Not for use in Diagnostic Procedures. Trademarks and/or registered trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners in the United States and/or certain other countries. © 2020 DH Tech. Dev. Pte. Ltd. AGENDA AT A GLANCE AGENDA AT A GLANCE US HUPO PROGRAM OVERVIEW 2020 SAT, MARCH 7 - SUN, MARCH 8 MON, MARCH 9 TUES, MARCH 10 WED, MARCH 11 8:00 – 8:30 am 8:00 – 8:30 am 8:00 – 8:30 am SATURDAY Early Morning Coffee Early Morning Coffee Early Morning Coffee Exhibits Exhibits Grand Foyer Grand 2&3 Grand 2&3 9:00 am - 4:00 pm 8:30 – 9:20 am 8:30 – 9:20 am 8:30 – 9:20 am Full-Day Course, Day 1 Plenary Session Plenary Session Plenary Session Design and Analysis of Quantitative Catherine E. Costello Lifetime Achievement in New Investigator Award Tips & Tricks Lightning Session Proteomics Experiments Proteomics Award Lecture Si Wu and Nicolas Young Grand 1 Vashon Ruedi Aebersold Grand 1 Computational Proteomics Jimmy Eng Grand 1 9:20 – 9:50 am 9:20 – 9:50 am 9:20 – 9:50 am SUNDAY Coffee Break with Exhibits Coffee Break with Exhibits Coffee Break Grand 2&3 Grand 2&3 Grand Foyer 9:00 am - 4:00 pm 9:50 – 11:10 am 9:50 – 11:10 am 9:50 – 11:10 am Full-Day Short Course, Day 2 Parallel Sessions Parallel Sessions Parallel Sessions Design and Analysis of Quantitative Cascadia Proteomics Symposium Session Computation & Analysis: Computational and Computation & Analysis: Novel ‘omics and Proteomics Experiments Grand 1 Statistical Methods Multiomics: Data Integration and Vashon Grand 1 Applications Cell Biology: Proteomic Analysis of PTMS and Fifth Avenue Proteoforms Cell Biology: Systems Approaches for Fifth Avenue Cellular Signaling Cell Biology: Regulation and Fifth Avenue Function of Protein Phosphorylation Grand 1 9:00 am - 12:00 pm 11:10 am – 12:00 pm 11:10 am – 12:00 pm 11:10 am – 12:00 pm Morning Short Courses Plenary Session Plenary Session Plenary Session Cross-Linking Mass Spectrometry Lightning Talks – Round I Lightning Talks – Round II Donald F. Hunt Distinguished Contribution Cascade 1 Grand 1 Grand 1 in Proteomics Award Lecture Steven Gygi Precision Medicine: From Biomarker Grand 1 Discovery to FDA Cascade 2 1:00 – 4:00 pm 12:15 – 1:30 pm 12:15 – 1:30 pm Afternoon Short Course Bruker Lunch Seminar SCIEX Lunch Seminar Stable and Transient Protein-Protein Cascade Room 2 Cascade Room 2 Interactions Cascade 2 Thermo Lunch Seminar Thermo Lunch Seminar Cascade Room 1 Cascade Room 1 4:30 – 5:45 pm 1:30 - 3:00 pm 1:30 - 3:00 pm Workshop Poster Session & Break Poster Session & Break Grand 2 & 3 Grand 2 & 3 Career Development Event/Workshop 3:00 – 4:20 pm 3:00 – 4:20 pm 6:00 – 7:00 pm Parallel Sessions Parallel Sessions Opening Plenary Session Advances in Technology Technology: New Developments in Grand 1 Structural Proteomics Carol Robinson Grand 1 Grand 1 Proteomics of Disease: Aging and Age- Vashon Related Diseases Proteomics of Disease: Cancer and Fifth Avenue Precision Medicine Fifth Avenue 4:30 – 5:50 pm 4:30 – 5:50 pm Parallel Sessions Parallel Sessions 7:00 – 8:30 pm Welcome Reception Technology: Innovations in Biological Sample Technology: Chemical Proteomics and Drug Mixer with Exhibits Processing Discovery Grand 2 & 3 Grand 1 Grand 1 Proteomics of Disease: Alzheimer’s and Proteomics of Disease: Immunity and Neurodegenerative Diseases Infectious Disease Fifth Avenue Fifth Avenue 6:00 – 7:30 pm Workshops 5:50 – 6:30 pm Biomarkers for Cancer, Early Detection Mixer with Exhibitors Cascade 1 Grand 2 & 3 Putting Humpty Dumpty Back Together Again: What Does Protein Quant Mean in Bottom-Up Proteomics? Cascade 2 Workshops 7:30 – 9:00 pm Proteomics of Aging Cascade 2 Evening Social & Music with Exhibits Grand 2 & 3 Data-Independent Acquisition (DIA) Workflows Cascade 1 16th Annual US HUPO 2020 Conference 7 Go beyond faster with more actionable insights Harness the power of proteomics with built-in workflows and single cell sensitivity that accelerate your path to impactful results Visit us at booth #300 to learn about proteomics solutions that can help you go forth confidently. Attend our lunchtime workshops 12:15 – 1:30 pm Monday March 9: Redefining Standards in Identification, Quantitation and Sensitivity with the new Thermo Scientific™ Thermo Scientific™ Orbitrap Exploris 480 Mass Spectrometer Orbitrap Eclipse™ Tribrid™ Mass Spectrometer Orbitrap Exploris™ 480 Mass Spectrometer Tuesday March 10: One Cell at a Time – Single Cell By collaborating with the scientific community, we’ve developed pioneering Proteomics Becomes A Reality proteomics solutions such as Thermo Scientific™ Orbitrap™ LC-MS instruments, consumables, and workflows. These industry-leading solutions can help you identify and quantify proteins faster with industry leading sensitivity, so you can go beyond the limit of what was ever thought possible. Find out more at thermofisher.com/proteomics © 2020 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. AD90561-EN 0120S EXHIBITORS US HUPO is pleased to acknowledge the support of conference exhibitors.
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