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High Author (ref) N Quality Intervention Indication oOutcome Gastroenterology Alam (2) 55 No Trimethoprim-sulphamethoxazole Diarrhoea Duration of diarrhoea Battaglia (7) 325 No Otilonium bromide Irritable bowel syndrome Global assessment, other Cezard (18) 67 No Racecadotril Diarrhoea Duration of diarrhoea Gade (38) 54 Yes Paraghurt® Irritable bowel syndrome Global assessment, physician Hovdenak (46) 12 No Irritable bowel syndrome Global assessment, patient Kaplan (53) 256 Yes Loperamide Diarrhoea Duration of diarrhoea Maria (57) 27 No Botulinum toxin Anal fissure Global assessment, physician Milo (64) 66 No Domperidone Irritable bowel syndrome Global assessment, other Nayak (69) 30 No Metronidazole 2g Irritable bowel syndrome Pain Rossignol (82) 89 No Nitazoxanide Intestinal infection Global assessment, other Sand (86) 25 No Nifedipine Gallbladder stones Pain Skoubo-Kirstensen (93) 58 No Sucralfate Gastritis Global assessment, patient Gynecology & obstetrics Bettigole (12) 33 No Fenoprofen Childbirth Pain Demory (27) 48 No Pyrrolidone carboxylate of Childbirth Dystocia Di Carlo (28) 28 No Leuprolide acetate + tibolone Premenstrual syndrome Depression Eriksson (33) 44 No Paroxetin Premenstrual syndrome Global assessment, patient Fleming (35) 92 No Metformin Oligomenorrhoea Global assessment, physician Grio (41) 88 No Tamoxifen Premenstrual syndrome Global assessment, other Hopkinson (44) 141 No Ibuprofen Childbirth Pain Humphrey (49) 89 Yes Sulindac Childbirth Occurrence of preterm labour Louviere (56) 450 No Deladumone OB Breastfeeding Pain McCaul (58) 84 No Ampicillin Childbirth Time to delivery Mendes (63) 19 No Metoclopramide Amenorrhoea Global assessment, physician Stein (95) 70 No Itraconazole Vaginal candidiasis Global assessment, physician Von Holst (106) 173 No Estradiol Postmenopausal complaints Flushes Warren (107) 50 No Sequential antibiotics Cystitis Global assessment, patient

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Note that an earlier version of this table (Study_characteristics_of_allopathy_studies.pdf ) posted on our website on Dec 17, 2005 was incorrect due to errors occurring during the production of the graphs. The current version was posted on our website on Dec 23, 2005. High Author (ref) N Quality Intervention Indication Outcome Musculoscelettal complaints Barlas (6) 24 No Aspirin Physical activity Pain Giner (39) 103 No Emla® Arterial cannulation Pain Grossman (42) 20 No Ibuprofen Physical activity Soreness Lacey (54) 1282 No Piroxicam Soft tissue injury Global assessment, physician McLatchie (59) 67 No Ibuprofen Ankle sprains Global assessment, physician Memeo (61) 100 No Flurbiprofen Soft tissue injury Global assessment, patient Paddon-Jones (74) 17 No Beta-hydroxy-beta-methylbutyrate Muscle damage Soreness Ramesh (78) 80 No Ibuprofen Injuries Global assessment, patient Semark (91) 25 No Flurbiprofen Physical activity Soreness Thompson (101) 16 No Vitamin C Physical activity Soreness Weller (108) 20 No Magnesium Physical activity Global assessment, patient Neurology Attias (4) 38 No Scopolamine Seasickness Global assessment, patient Diamond (29) 63 No Migraine Global assessment, patient Goldstein (40) 80 No Lanepitant Migraine Migraine attacks Horn (45) 454 Yes Nimodipine Stroke Occurrence of poor outcome Huber (47) 50 No Aphasia Global assessment, physician Narotam (68) 20 No CP-0127 Brain injury Global assessment, physician Sacco (84) 1367 No Gavestinel Stroke Death Schmitt (89) 57 No Botulinum toxin A Headache Pain Shupak (92) 66 No Cinnarizine Seasickness Global assessment, patient Storey (97) 40 No Migraine Frequency of attacks 0.00001 0.0001 0.001 0.01 0.1 1 10 100 High Author (ref) N Quality Intervention Indication Outcome Pollinosis and asthma Althaus (3) 127 No N-acetyl-aspartyl Pollinosis Ocular symptoms Bergmann (10) 123 No Beclomethasone dipropionate Asthma FEV1 Bodtger (16) 34 No Immunotherapy Pollinosis Global assessment, patient Boos (14) 131 No Nedocromil sodium Asthma FEV1 Brunet (17) 27 No Immunotherapy Pollinosis Global assessment, patient Ciprandi (20) 20 No Acetylsalicylic acid Pollinosis Global assessment, physician Ciprandi (19) 39 No Cromoglycate + chlorphenamine Pollinosis Global assessment, other Davis (24) 57 No Levocabastine Conjunctivitis Global assessment, physician Huerta Lopez (48) 60 No Ketotifen Asthma Global assessment, physician Munk (67) 140 No Triamcinolone acetonide Allergic rhinitis Global assessment, patient Möller (66) 146 Yes Nedocromil sodium Pollinosis Global assessment, other Reid (79) 66 No Sodium cromoglycate Asthma PEFR Stelmach (96) 32 No Nedocromil sodium Asthma Global assessment, other Taudorf (100) 37 No Immunotherapy Pollinosis Ocular symptoms Wüthrich (109) 35 No Disodium cromoglycate Pollinosis Global assessment, patient de Molina (26) 65 No Ebastine Rhinitis Global assessment, patient Respiratory tract infections Belshe (8) 1358 No Influenza vaccine Influenza Occurrence of influenza Bertin (11) 146 No Ibuprofen Otitis media Pain Cohen (21) 19 No Ribavirin Influenza Occurrence of influenza Crawford (22) 56 No Influenza Occurrence of influenza like disease De Flora (25) 248 Yes N- Influenza like disease Occurrence of influenza like disease Dolin (30) 265 No Rimantadine Influenza Occurrence of influenza like disease Frachet (36) 90 No Tiaprofenic acid Sinusitis Global assessment, patient Hutton (50) 54 No Dimetapp® Common cold Global assessment, other Kaiser (52) 285 No Zanamivir Influenza Occurrence of influenza like disease Morrone (65) 17 No Moguisteine Cough Global assessment, patient Nelson (71) 34 No Penicillin Pharyngitis Global assessment, other Nicholson (72) 319 Yes Oseltamivir Influenza Global assessment, other Peters (76) 548 No Oseltamivir Influenza Occurrence of influenza Reuman (80) 316 Yes hydrochloride Influenza Occurrence of influenza Rodriguez (81) 74 No Immune globuline Respiratory tract infection Global assessment, physician Ruohola (83) 208 No Fluticasone propionate Otitis media Occurrence of acute otitis media Schlenter (88) 262 No Broncho-Vaxom® Sinusitis Headache Sclafani (90) 164 No Amoxicillin/clavulanate potassium Adenotonsillar hypertrophy Global assessment, physician Treanor (102) 253 No Oseltamivir Influenza Temperature Van Eygen (103) 70 No Levamisole Respiratory tract infection Occurrence of symptoms Van Voris (104) 31 No Rimantadine hydrochloride Influenza Global assessment, other 0.00001 0.0001 0.001 0.01 0.1 1 10 100 High Author (ref) N Quality Intervention Indication Outcome Surgery & anesthesiology Benson (9) 23 No Cisapride Postoperative ileus Time to first wind Boghaert (13) 53 No Cisapride Postoperative Ileus Occurrence of first wind Crowley (23) 273 Yes Metronidazole Postoperative infection Occurrence of postoperative infection Hoernecke (43) 80 No Wobenzyme® Hand surgery Pain Ilkjaer (51) 50 No Hysterectomy Pain Mehnert (60) 100 No Indomethacin Tooth extraction Pain Mendel (62) 34 No Alfentanil Postoperative agitation Agitation Negro (70) 30 No 2alpha-thenoylthiopropionylglycine Postoperative lung complications Occurrence of complications Oertli (73) 153 No Tranexamic acid Surgery Occurrence of haematomas Sadek (85) 89 No Ceruletide Postoperative ileus Time to first wind Schäffer (87) 34 No Nalbuphine Surgery Pain Taguchi (99) 52 No ADL8-2698 Postoperative ileus Occurrence of first wind Miscellanous Adamietz (1) 38 No Povidone-iodine Mucositis Global assessment, other Bahadori (5) 17 No Chromium picolinate Obesity BMI Boureau (15) 38 No Paracetamol+ Rheumatoid Arthritis Global assessment, patient Dominguez (31) 57 No Hidrosmin Venous insufficiency Pain Enzi (32) 133 No Dexfenfluramine Obesity Body weight Eron (34) 257 No Interferon alpha-2b Condylomata acuminata Global assessment, physician Frattola (37) 37 No Alpidem Anxiety Anxiety Lievens (55) 83 No Sucralfate Radiotherapy Mucositis Patterson (75) 65 No Lorazepam Burns Pain Petrovic (77) 39 No Lormetazepam Benzodiazepine withdrawal Global assessment, other Smolen (94) 221 No Leflunomide Rheumatoid Arthritis Global assessment, physician Taddio (98) 60 No Lidocaine-prilocaine Injection Pain Vercoulen (105) 95 No Fluoxetine Chronic fatigue syndrome Global assessment, patient Yazar (110) 70 No Silver nitrate Warts Global assessment, other

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