Congenital Corneal Clouding: a Case Series
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Deep Learning Analysis of Eye Fundus Images to Support Medical Diagnosis
Deep learning analysis of eye fundus images to support medical diagnosis Oscar Juli´anPerdomo Charry Universidad Nacional de Colombia Departamento de Ingenier´ıade Sistemas e Industrial Bogot´a,Colombia 2020 Deep learning analysis of eye fundus images to support medical diagnosis Oscar Juli´anPerdomo Charry Thesis submitted as requirement to obtain the title of: PhD. in Systems and Computer Engineering Advisor: Fabio A. Gonz´alez,Ph.D. Universidad Nacional de Colombia Departamento de Ingenier´ıade Sistemas e Industrial Bogot´a,Colombia 2020 Deep learning analysis of eye fundus images to support medical diagnosis Oscar Perdomo Dedication To my muse and beautiful wife Ana To my parents Alvaro´ and Isabel To my brothers Kike and Cesar Abstract Machine learning techniques have been successfully applied to support medical decision making of cancer, heart diseases and degenerative diseases of the brain. In particular, deep learning methods have been used for early detection of abnormalities in the eye that could improve the diagnosis of different ocular diseases, especially in developing countries, where there are major limitations to access to specialized medical treatment. However, the early detection of clinical signs such as blood vessel, optic disc alterations, exudates, hemorrhages, drusen, and microaneurysms presents three main challenges: the ocular images can be affected by noise artifact, the features of the clinical signs depend specifically on the acquisition source, and the combination of local signs and grading disease label is not an easy task. This research approaches the problem of combining local signs and global labels of different acquisition sources of medical information as a valuable tool to support medical decision making in ocular diseases. -
Usage of Laser Induced Bubbles for Measuring Intraocular Eye Pressure
ALTIND Fatih Fatih İŞ USAGE OF LASER INDUCED BUBBLES USAGE OF LASER INDUCED BUBBLES FOR MEASURING MEASURING FOR BUBBLES INDUCED LASER OF USAGE FOR MEASURING INTRAOCULAR EYE PRESSURE INTRAOCULAREYE A THESIS SUBMITTED TO THE DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING AND THE GRADUATE SCHOOL OF ENGINEERING AND SCIENCE OF PRESSURE ABDULLAH GUL UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER IN SCIENCE By Fatih ALTINDİŞ AGU 2017 December 2017 i USAGE OF LASER INDUCED BUBBLES FOR MEASURING INTRAOCULAR EYE PRESSURE A THESIS SUBMITTED TO THE DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING AND THE GRADUATE SCHOOL OF ENGINEERING AND SCIENCE OF ABDULLAH GUL UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER IN SCIENCE By Fatih ALTINDİŞ December 2017 ii SCIENTIFIC ETHICS COMPLIANCE I hereby declare that all information in this document has been obtained in accordance with academic rules and ethical conduct. I also declare that, as required by these rules and conduct, I have fully cited and referenced all materials and results that are not original to this work. Fatih ALTINDIŞ iii REGULATORY COMPLIANCE M.Sc. thesis titled USAGE OF LASER INDUCED BUBBLES FOR MEASURING INTRAOCULAR PRESSURE has been prepared in accordance with the Thesis Writing Guidelines of the Abdullah Gül University, Graduate School of Engineering & Science. Prepared By Advisor Fatih ALTINDIŞ Prof. Bülent YILMAZ Head of the Electrical and Computer Engineering Program Assoc. Prof. V. Çağrı GÜNGÖR iv ACCEPTANCE AND APPROVAL M.Sc. thesis titled USAGE OF LASER INDUCED BUBBLES FOR MEASURING INTRAOCULAR PRESSURE and prepared by Fatih Altındiş has been accepted by the jury in the Electrical and Computer Engineering Graduate Program at Abdullah Gül University, Graduate School of Engineering & Science. -
Factors Affecting Measurements of Iop Using Non-Contact Eye Tonometer
Strojnícky časopis – Journal of MECHANICAL ENGINEERING, VOL 70 (2020), NO 2, 133 - 140 FACTORS AFFECTING MEASUREMENTS OF IOP USING NON-CONTACT EYE TONOMETER RYBÁŘ Jan1, HUČKO Branislav2*, ĎURIŠ Stanislav1, PAVLÁSEK Peter3,1, CHYTIL Miroslav3, FURDOVÁ Alena4, VESELÝ Pavol4,5 1Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Automation, Measurement and Applied Informatics, Mýtna 36, 811 07 Bratislava, Slovakia 2Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Applied Mechanics and Mechatronics, Nám. slobody 17, 812 31 Bratislava, Slovakia, e – mail: [email protected] 3Slovak Metrology Institute, Karloveská 63, 842 55 Bratislava 4, Slovakia 4University Hospital Bratislava, Ophthalmology Clinic LFUK and UNB, Ružinovská 6, 826 06 Bratislava, Slovakia 5VESELY Očná klinika, s.r.o, Karadžičova 16, 821 08Bratislava, Slovakia Abstract: The objective measurement of intraocular pressure (IOP) represents the identification of the symptoms of some diseases, e.g. glaucoma. This objective measurement can only be achieved by correct calibration of tonometers. Today, there is no uniform methodology for this calibration. Therefore, we introduce potential sources of error and try to quantify their contributions in this paper. Subsequently, a calibration standard containing an artificial cornea with similar properties to the human one should be designed. KEYWORDS: measurement, intraocular pressure, non-contact eye tonometer, uncertainties and factors 1 Introduction Correct metrological assurance in ocular tonometry is very important in the prevention of such insidious diseases as glaucoma. Specifically, to ensure accurate measurement of intraocular pressure with eye tonometer is the goal of our efforts. The most commonly used type of ophthalmological tonometers in ophthalmic practice are those that measure eye pressure using contactless methods. -
Effect of Macular Hole Volume on Postoperative Central Macular Thickness O Efeito Do Volume De Buraco Macular Da Espessura Macular Central Pós-Operatória
ORIGINAL ARTICLE Effect of macular hole volume on postoperative central macular thickness O efeito do volume de buraco macular da espessura macular central pós-operatória TAYLAN OZTURK1, EYYUP KARAHAN2, DUYGU ER1, MAHMUT KAYA1, NILUFER KOCAK1, SULEYMAN KAYNAK1 ABSTRACT RESUMO Purpose: To evaluate the association between macular hole volume (MHV) and Objetivo: Avaliar a relação entre o volume do buraco macular (MHV) e a espessura postoperative central macular thickness (CMT) using spectral-domain optical macular central pós-operatória (CMT) por meio da tomografia de coerência óptica coherence tomography (SD-OCT). de domínio espectral (SD-OCT). Methods: Thirty-three eyes of 30 patients with a large full-thickness idiopathic Método: Trinta e três olhos de 30 pacientes com buracos maculares idiopáticos de macular hole with or without vitreomacular traction who underwent surgical espessura total grandes, com ou sem tração vitreorretiniana, que foram submetidos a intervention were included in this cross-sectional study. Complete ophthalmo- intervenção cirúrgica foram incluídos neste estudo transversal. O exame oftalmo- logical examination, including SD-OCT, was performed for all participants du- lógico completo, incluindo SD-OCT foi realizado nas visitas pré e pós-operatórias ring the pre- and postoperative visits. MHV was preoperatively measured using de todos os participantes. MHV foi medido a partir da imagem de SD-OCT pré- SD-OCT, which captured the widest cross-sectional image of the hole. For normal -operatória que capturou a imagem mais larga da secção transversal do buraco. distribution analysis of the data, the Kolmogorov-Smirnov test was performed, Após a análise distribuição nomral da população do estudo ter sido realizada com and for statistical analyses, chi-square, Student’s t-test, Mann-Whitney U test, and o teste Kolmogorov-Smirnov, os testes de qui-quadrado, t de Student, Mann-Whitney Pearson’s correlation coefficient test were performed. -
Clinical Studies Articles Testimonials Feline Breeds Predisposed to Glaucoma
DNA CLINICAL STUDIES ARTICLES TESTIMONIALS FELINE BREEDS PREDISPOSED TO GLAUCOMA Persians Siamese Domestic Short-Hair CANINE BREEDS PREDISPOSED TO GLAUCOMA Afghan Dalmatian Norwich Terrier Akita Dandie Dinmont Terrier Pekingese Alaskan Malamute English Cocker Spaniel Pembroke Welsh Corgi American Eskimo Dog English Springer Spaniel Petit Basset Griffon Vendéen Australian Cattle Dog Entlebucher Mountain Dog Poodle (all varieties) Basset Hound Flat-coated Retriever Pug Beagle Fox Terrier (all varieties) Saluki Bedlington Terrier Golden Retriever Samoyed Bichon Frise Great Dane Schnauzer (all varieties) Blue Healer Greyhound Scottish Terrier Border Collie Irish Setter Sealyham Terrier Boston Terrier Italian Greyhound Shar Pei Bouvier des Flanders Brittany Keeshond Shiba Inu Brittany Labrador Retriever Shih Tzu Bullmastiff Lakeland Terrier Siberian Husky Cairn Terrier Maltese Skye Terrier Cardigan Welsh Corgi Manchester Terrier Tibetan Terrier Chihuahua Miniature Pinscher Welsh Springer Spaniel Chow Chow Newfoundland Welsh Terrier Cocker Spaniel Norfolk Terrier West Highland Terrier Dachshund Norwegian Elkhound ICARE TONOVET TECHNICAL INFORMATION TYPE: TV01 DIMENSIONS: 13 – 32 mm (W) * 45 – 80 mm (H) * 230 mm (L) WEIGHT: 155 g (without batteries), 250 g (4 x AA batteries) POWER SUPPLY: 4 x AA batteries DISPLAY RANGE: 0-99 mmHg ACCURACY OF DISPLAY: 1 DISPLAY UNIT: Millimeter mercury (mmHg) STORAGE/TRANSPORTATION ENVIRONMENT: Temperature +5 to +40 °C Rel. humidity 10 to 80% (without condensation) The device conforms to CE regulations. For veterinary use only. There are no electrical connections from the tonometer to the patient. The device has B-type electric shock protection. 2 WWW.ICARETONOMETER.COM FAQ IS THE TONOVET MEASUREMENT PAINLESS? CAN SAME PROBE BE USED TO MEASURE BOTH Measurement is painless, the light-weight probe touches EYES OF ONE PATIENT? the cornea momentarily and very gently, and most pa- Yes, same probe can be used to measure both eyes of one tients don’t even notice the measurement. -
Echographic Evaluation of a Subconjunctival Cystic Lesion
Hindawi Case Reports in Ophthalmological Medicine Volume 2017, Article ID 5401850, 3 pages https://doi.org/10.1155/2017/5401850 Case Report Echographic Evaluation of a Subconjunctival Cystic Lesion Maddalena De Bernardo,1 Gennarfrancesco Iaccarino,2 Valeria Russo,1 and Nicola Rosa1 1 DepartmentofMedicineandSurgery,UniversityofSalerno,Salerno,Italy 22ndUniversityofNaples,Naples,Italy Correspondence should be addressed to Nicola Rosa; [email protected] Received 27 February 2017; Accepted 3 April 2017; Published 12 April 2017 Academic Editor: Claudio Campa Copyright © 2017 Maddalena De Bernardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Migration of intraocular silicone oil, used in the treatment of complicated retinal detachment, has been rarely described, but when it happens it can arise with a differential diagnosis with scleral buckling extrusion, tumor, dermoid, ocular cysticercosis, and abscess. The presence of silicone oil in the eye gives very ugly echographic pictures, but these kinds of pictures can bevery useful in making a differential diagnosis in the above-mentioned cases. A 39-year-old white female complained of the presence of conjunctival hyperemia and tearing in the right eye (RE); her visual acuity was hand motion, and the intraocular pressure was 14 mmHg. In the upper nasal quadrant a dome shaped lesion was detected. Due to the lens opacities, the patient underwent an echographic examination, which revealed the presence of silicon oil both in the vitreous chamber and in a large subconjunctival space, corresponding to the lesion. This article in addition provides a possible explanation of such cystic formation and discusses the risk factors and the role of the echographic examination in such cases. -
Congenital Ocular Anomalies in Newborns: a Practical Atlas
www.jpnim.com Open Access eISSN: 2281-0692 Journal of Pediatric and Neonatal Individualized Medicine 2020;9(2):e090207 doi: 10.7363/090207 Received: 2019 Jul 19; revised: 2019 Jul 23; accepted: 2019 Jul 24; published online: 2020 Sept 04 Mini Atlas Congenital ocular anomalies in newborns: a practical atlas Federico Mecarini1, Vassilios Fanos1,2, Giangiorgio Crisponi1 1Neonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria Cagliari, University of Cagliari, Cagliari, Italy 2Department of Surgery, University of Cagliari, Cagliari, Italy Abstract All newborns should be examined for ocular structural abnormalities, an essential part of the newborn assessment. Early detection of congenital ocular disorders is important to begin appropriate medical or surgical therapy and to prevent visual problems and blindness, which could deeply affect a child’s life. The present review aims to describe the main congenital ocular anomalies in newborns and provide images in order to help the physician in current clinical practice. Keywords Congenital ocular anomalies, newborn, anophthalmia, microphthalmia, aniridia, iris coloboma, glaucoma, blepharoptosis, epibulbar dermoids, eyelid haemangioma, hypertelorism, hypotelorism, ankyloblepharon filiforme adnatum, dacryocystitis, dacryostenosis, blepharophimosis, chemosis, blue sclera, corneal opacity. Corresponding author Federico Mecarini, MD, Neonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria Cagliari, University of Cagliari, Cagliari, Italy; tel.: (+39) 3298343193; e-mail: [email protected]. -
Disinfection of Tonometers a Report by the American Academy of Ophthalmology
Ophthalmic Technology Assessment Disinfection of Tonometers A Report by the American Academy of Ophthalmology Anna K. Junk, MD,1 Philip P. Chen, MD,2 Shan C. Lin, MD,3 Kouros Nouri-Mahdavi, MD,4 Sunita Radhakrishnan, MD,5 Kuldev Singh, MD, MPH,6 Teresa C. Chen, MD7 Objective: To examine the efficacy of various disinfection methods for reusable tonometer prisms in eye care and to highlight how disinfectants can damage tonometer tips and cause subsequent patient harm. Methods: Literature searches were conducted last in October 2016 in the PubMed and the Cochrane Library databases for original research investigations. Reviews, non-English language articles, nonophthalmology articles, surveys, and case reports were excluded. Results: The searches initially yielded 64 unique citations. After exclusion criteria were applied, 10 labo- ratory studies remained for this review. Nine of the 10 studies used tonometer prisms and 1 used steel discs. The infectious agents covered in this assessment include adenovirus 8 and 19, herpes simplex virus (HSV) 1 and 2, human immunodeficiency virus 1, hepatitis C virus, enterovirus 70, and variant Creutzfeldt-Jakob disease. All 4 studies of adenovirus 8 concluded that after sodium hypochlorite (dilute bleach) disinfection, the virus was undetectable, but only 2 of the 4 studies found that 70% isopropyl alcohol (e.g., alcohol wipes or soaks) eradicated all viable virus. All 3 HSV studies concluded that both sodium hypochlorite and 70% isopropyl alcohol eliminated HSV. Ethanol, 70% isopropyl alcohol, dilute bleach, and mechanical cleaning all lack the ability to remove cellular debris completely, which is necessary to prevent prion transmission. Therefore, single-use tonometer tips or disposable tonometer covers should be considered when treating patients with suspected prion disease. -
Applanation Tonometry: a Comparison of the Perkins Handheld and Goldmann Slit Lamp-Mounted Methods
Clinical Ophthalmology Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Applanation tonometry: a comparison of the Perkins handheld and Goldmann slit lamp-mounted methods R Arora1 Purpose: To compare intraocular pressure (IOP) measurements, taken using Perkins H Bellamy2 applanation tonometry (PAT) and Goldmann applanation tonometry (GAT). MW Austin2 Methods: 100 eyes of 100 patients underwent Perkins and Goldmann applanation tonometry, with a randomized order of modality, performed by a masked observer. The right eye was 1University Hospital of Southampton, Southampton, Hampshire, 2Singleton measured, for all subjects, and the data used in statistical analysis. The comparability of results Hospital, Abertawe Bro Morgannwg given by the two instruments was evaluated using the Bland–Altman method. University Health Board, Swansea, IOP measurements for 100 eyes were obtained (range: 10–44 mmHg). The mean GAT Wales, UK Results: reading was 21.63 mmHg, with standard deviation (SD) 5.69 mmHg. The mean PAT reading was 21.40 mmHg, with SD 5.67 mmHg. The mean difference between readings from Goldmann For personal use only. versus Perkins tonometry was 0.22 mmHg (SD: 0.44 mmHg). The limits of agreement were calculated to be −0.64–+1.08 mmHg (1.96 SD either side of the bias). Conclusion: The Perkins applanation tonometer yields IOP measurements that are closely comparable with GAT. Therefore, PAT may be used in routine clinical practice, as part of the implementation of national guidelines, -
Preliminary Results of an Intravitreal Dexamethasone Implant (Ozurdex®) in Patients with Persistent Diabetic Macular Edema
Clinical Ophthalmology Dovepress open access to scientific and medical research Open Access Full Text Article MethodoloGY Preliminary results of an intravitreal dexamethasone implant (Ozurdex®) in patients with persistent diabetic macular edema Elena Pacella1 Background: To evaluate the efficacy and safety of an intravitreal dexamethasone implant Anna Rita Vestri2 (Ozurdex®; Allergan Inc, Irvine, CA, USA) in patients with persistent diabetic macular edema Roberto Muscella1 (DME) over a 6-month follow-up period. Maria Rosaria Carbotti1 Methods: Seventeen patients (20 eyes) affected by DME were selected. The mean age was Massimo Castellucci1 67 ± 8 years, and the mean duration of DME was 46.3 ± 18.6 months. The eligibility criteria Luigi Coi1 were: age $18, a best-corrected visual acuity between 5 and 40 letters, and macular edema with a thickness of $275 m. Thirteen patients had also previously been treated with anti-vascular Paolo Turchetti3 µ endothelial growth factor medication. Fernanda Pacella1 Results: The mean ETDRS (Early Treatment Diabetic Retinopathy Study) value went from 1 For personal use only. Department of Sense Organs, 18.80 ± 11.06 (T0) to 26.15 ± 11.03 (P = 0.04), 28.15 ± 10.29 (P = 0.0087), 25.95 ± 10.74 Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, (P = 0.045), 21.25 ± 11.46 (P = 0.5) in month 1, 3, 4, and 6, respectively. The mean logMAR Italy; 2Department of Public Health (logarithm of the minimum angle of resolution) value went from 0.67 ± 0.23 (at T0) to and Infectious Diseases, Faculty of 0.525 ± 0.190 (P = 0.03), 0.53 ± 0.20 (P = 0.034), and 0.56 ± 0.22 (P = 0.12) in month 1, 3, Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy; and 4, respectively, to finally reach 0.67 ± 0.23 in month 6. -
UCLA Previously Published Works
UCLA UCLA Previously Published Works Title The interplay of genetics and surgery in ophthalmic care. Permalink https://escholarship.org/uc/item/7nj489hp Journal Seminars in ophthalmology, 10(4) ISSN 0882-0538 Author Gorin, MB Publication Date 1995-12-01 DOI 10.3109/08820539509063801 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Seminars in Ophthalmology ISSN: 0882-0538 (Print) 1744-5205 (Online) Journal homepage: http://www.tandfonline.com/loi/isio20 The Interplay of Genetics and Surgery in Ophthalmic Care Michael B. Gorin To cite this article: Michael B. Gorin (1995) The Interplay of Genetics and Surgery in Ophthalmic Care, Seminars in Ophthalmology, 10:4, 303-317, DOI: 10.3109/08820539509063801 To link to this article: http://dx.doi.org/10.3109/08820539509063801 Published online: 02 Jul 2009. Submit your article to this journal Article views: 9 View related articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=isio20 Download by: [UCLA Library] Date: 02 May 2017, At: 14:05 The Interplay of Genetics and Surgery in Ophthalmic Care Michael 6. Gorin LTHOUGH ONLY a minor component of dures. Genetic conditions that affect the eye A the surgical volume of ophthalmic care, directly may also affect the surgicaI outcomes of genetic disorders are among the most challeng- routine procedures. The coexistence of Fuch’s ing cases for the ophthalmic surgeon. Ophthal- endothelial dystrophy in patients undergoing mic surgery may be indicated to address specific routine cataract extraction can contribute to aspects of heritable disorders that involve the postoperative corneal edema. -
Current Molecular Understanding of Axenfeld-Rieger Syndrome
Current molecular understanding of Axenfeld-Rieger syndrome. Hjalt, Tord; Semina, Elena V Published in: Expert Reviews in Molecular Medicine DOI: 10.1017/S1462399405010082 2005 Link to publication Citation for published version (APA): Hjalt, T., & Semina, E. V. (2005). Current molecular understanding of Axenfeld-Rieger syndrome. Expert Reviews in Molecular Medicine, 7(25), 1-17. https://doi.org/10.1017/S1462399405010082 Total number of authors: 2 General rights Unless other specific re-use rights are stated the following general rights apply: Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Read more about Creative commons licenses: https://creativecommons.org/licenses/ Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. LUND UNIVERSITY PO Box 117 221 00 Lund +46 46-222 00 00 expert reviews http://www.expertreviews.org/ in molecular medicine Current molecular understanding of Axenfeld–Rieger syndrome Tord A. Hjalt and Elena V. Semina Axenfeld–Rieger syndrome (ARS) is a rare autosomal dominant inherited disorder affecting the development of the eyes, teeth and abdomen.