T10E-H10E

Boronic acid reagents

Boronic acids are alkyl or aryl substituted carbon to a boron di-iol group (class of organoboranes): . R-B(OH)2 . As Lewis acids, this chemical functional group is capable of forming reversible covalent complexes with sugars, amino acids, hydroxamic acids, etc. The pKa of a boronic acid is ~9, but upon complexion in aqueous solutions, they form tetrahedral boronate complexes with pKa ~7.

Hence, boronic acids drive unique features and applications:

 Boronic acids chemical building blocks are also used in organic chemistry (i.e. Suzuki coupling: R-B(OH)2 + R’-X ► R-R’ ; transmetallation of its organic residue to a transition metal). =>ask at [email protected] See exemples in article and in catalog [cat.Fine.201606] .

 Boronic acid conjugates of fluorescent dyes are used in biosciences to bind to saccharides for fluorescent detection, for selective transport of saccharides across membranes, or to block certain proteasomes. =>see Fluorescent boronic conjugates: Boronic derivate with Dansyl #FP-M1201A and Eosin #FP-CJ0760 Coumarin Boronic Acid (Cba) Onoo Fluorescent Probe (332/400NM), #FP-1D1401, 10-50-100mg

 Boronic acid conjugated supports are used for affinity =>see Boronic functionalized supports for affinity purification. See PH-BB190b Boronic acid on magnetic beads, 1µm, 2.5% (w/v) #7A2610, 2ml

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