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Home , Poloxamer 407, Sodium benzoate, Sorbitol

Competitive Comparison 3M™ Clinpro™

Fluoride Calcium Rx Is it a Product Size Type and Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by 3M • Clinically proven prescription-strength toothpaste • Remineralizes lesions throughout— not just on the surface • Delivers more fluoride to the tooth than other leading brands tested • Contains 1.1.% NaF (5000ppm fluoride ion) fluoride, , , hydrated silica, 3M™ Clinpro™ Functionalized • Contains tri-calcium phosphate ingredient (TCP), Vanilla Mint, 1.1% Sodium glycerin, polyethylene-, 5000 4oz Tricalcium so Clinpro 5000 toothpaste releases a high Yes Yes Spearmint, Fluoride , , sodium lauryl sulfate, Anti-Cavity (113g) Phosphate level of fluoride plus calcium and phosphate— Bubble Gum (5000ppm) titanium dioxide, carboxymethyl , Toothpaste (fTCP) components found naturally in saliva sodium and tri-calcium phosphate • Gentle cleaning, gentle whitening • Low abrasion • Use once daily in place of a conventional toothpaste • Available in a convenient 4oz flip-top tube (approx. 6-month patient supply) • Strengthens teeth better than leading brands • Lower fluoride, no prescription needed • Exclusive formula protects against cavities , water, sorbitol, hydrated silica, 3M™ Clinpro™ Functionalized and helps reverse white spots 0.21% Sodium glycerin, polyethylene-polypropylene glycol, Tooth Crème 4oz Tricalcium • Perfect for patients at moderate or high risk No Yes Vanilla Mint Fluoride flavor, polyethylene glycol, sodium lauryl sulfate, Anti-Cavity (113g) Phosphate of dental cavities (950ppm) titanium dioxide, carboxymethyl cellulose, Toothpaste (fTCP) sodium saccharin and tri-calcium phosphate • Cleans and whitens teeth with low abrasion • Contains fluoride as well as calcium and phosphate, which are components naturally found in saliva

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by Colgate-Palmolive Company Sodium fluoride, fumaric acid, hydrated silica, mica, PEG-12, 338, , Colgate® • Unique liquid formula 1.1% Sodium sodium carboxymethylcellulose, sodium lauryl PreviDent® 3.4oz Spearmint, Tricalcium • FluoriGard Technology™ Yes Yes Fluoride sulfate, sodium saccharine, sorbitol, titanium 5000 Booster (100mL) Fruitastic™ Phosphate (5000ppm) dioxide, tricalcium phosphate, water, xanthan gum. • Mild cleaning system with low abrasion Plus Also contains flavor, FD&C blue 1 dye (spearmint • Helps reverse white-spot lesions only), D&C red 33 dye (Fruitastic™ only) • Unique liquid gel formula Sodium fluoride, nitrate, purified water, Colgate® • Contains anti-sensitivity ingredient, 1.1% Sodium hydrated silica, sorbitol, PEG-12, sodium lauryl sulfate, PreviDent® 3.4oz 5% Yes Yes Mild Mint Fluoride No carrageenan, flavor, poloxamer 407, cocamidopropyl 5000 (100mL) (5000ppm) betaine, sodium saccharin, mica, , • Therapeutic decay prevention safe Sensitive titanium dioxide, FD&C blue no.1, D&C Yellow No.10 for exposed root surfaces • Low abrasion level Sodium fluoride, purified water, sorbitol, hydrated silica, PEG-12, tetrapotassium pyrophosphate, sodium Colgate® 1.1% Sodium lauryl sulfate, mint flavor (Spearmint flavor only), • Prescription-strength fluoride toothpaste 1.8oz Spearmint, PreviDent® Yes Yes Fluoride No xanthan gum, sodium benzoate, fruit flavor (Fruitastic™ • Significant remineralization of root caries (51g) Fruitastic™ 5000 Plus (5000ppm) flavor only), sodium saccharin, titanium dioxide • Great-tasting Spearmint and Fruitastic™ (Fruitastic™ flavor only), FD&C Blue #1 (Spearmint flavor only), D&C Red #33 (Fruitastic™ flavor only) • Reverses early root cavities Sodium fluoride, potassium nitrate water, Colgate® • Strengthens teeth and protects against acid wear 1.1% Sodium hydrated silica, sorbitol, PEG-12, sodium lauryl PreviDent® 3.4oz Yes Yes Mint Fluoride No sulfate, carrageenan, flavor, poloxamer 407, • Therapeutic decay prevention safe 5000 Enamel (100mL) (5000ppm) cocamidopropyl betaine, titanium dioxide, for exposed root surfaces Protect sodium saccharin, mica, sodium hydroxide • With clinically proven anti-sensitivity ingredient, 5% potassium nitrate, for effective sensitivity relief Sodium fluoride, water, sorbitol, hydrated silica, , glycerin, PEG-40 hydrogenated Colgate • Unique liquid gel formula 1.1% Sodium , dipotassium phosphate, poloxamer 407, PreviDent® 3.4oz Soothing • Significant remineralization of root caries Yes Yes Fluoride No flavor, PVM/MA copolymer, xanthan gum, sodium 5000 Dry (100mL) Mint (5000ppm) benzoate, sodium hydroxide, sodium saccharin, • SLS-free formula known to be less irritating Mouth cocamidopropyl betaine, , and less likely to cause dryness , pectin, FD&C Blue No. 1

Colgate® • Clinically proven Gel-Kam® 0.4% Stannous • Safe and effective for hypersensitivity, Fruit and Stannous fluoride, glycerin, Preventive No No 4.3oz Fluoride No caries control and decalcification Berry, Mint hydroxyethylcellulose, flavoring Treatment (1000ppm) • Available in drugstores without a prescription Gel (see pharmacist) Sodium fluoride, purified water, sorbitol solution 70%, hydroxyethylcellulose, pluronic F-127, • Proven clinically effective Colgate® 1.1% Sodium Very Berry, flavor, sodium saccharin, methyl paraben, • Safe for crowns and composite restorations PreviDent® Yes No 2oz Fluoride No Fresh Mint titanium dioxide, propylparaben, certified dyes Brush-on Gel (5000ppm) • Highest concentration of fluoride (FD&C Red #40 in Bing Cherry and Very Berry available for home use flavors, FD&C Blue #1 in Fresh Mint flavor)

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by Den-Mat Holdings, LLC Mint flavor contains: Sodium fluoride, cellulose gum, D&C Yellow No. 10, FD&C Blue No. 1, flavor, glycerin, mica (and) titanium dioxide, • Inhibition of demineralization and bacterial activity Fluoridex® 1.1% Sodium poloxamer 234, silica, sodium laurel sulfate, 4oz • Prevention and control of dental caries Daily Defense Yes Yes Fruit, Mint Fluoride No sodium saccharin, sorbitol, water, (112g) • Greater enamel resistance Toothpaste (5000ppm) Fruit flavor contains: Sodium fluoride, cellulose gum, D&C Red No. 33, flavor, glycerin, mica (and) • Enhanced remineralization titanium dioxide, poloxamer 234, silica, sodium laurel sulfate, sodium saccharin, sorbitol, water, xylitol • Offers the same anticaries benefits of the original Fluoridex® Sodium fluoride, cellulose gum, D&C Yellow No. 10, 1.1% Sodium Daily Defense formula, plus silica to help remove Enhanced 4oz FD&C Blue No. 1, flavor, glycerin, mica (and) titanium Yes Yes Clean Mint Fluoride No surface stains without the use of hydrogen peroxide. Whitening (112g) dioxide, poloxamer 234, silica, sodium laurel sulfate, (5000ppm) Toothpaste sodium saccharin, sorbitol, water, xylitol • Prescribe to patients who have recently undergone a whitening treatment, for ongoing shade maintenance Sodium fluoride, cellulose gum, D&C Yellow No. 10, Fluoridex® 1.1% Sodium FD&C Blue No. 1, flavor, glycerin, mica (and) titanium • Combines maximum-strength fluoride to inhibit Sensitivity 4oz Yes Yes Clean Mint Fluoride No dioxide, poloxamer 234, potassium nitrate, silica, caries and enhance remineralization, with Relief (112g) (5000ppm) sodium lauryl sulfate, sodium saccharin, sorbitol, 5% potassium nitrate for sensitivity relief Toothpaste water, xylitol Fluoridex® Sodium fluoride, cellulose gum, cocamidopropyl Sensitivity 1.1% Sodium betaine, D&C Yellow No. 10, FD&C Blue No. 1, • Provides the same maximum-strength fluoride 4oz Relief Yes Yes Clean Mint Fluoride No flavor, glycerin, mica (and) titanium dioxide, protection with 5% potassium nitrate for sensitivity (112g) SLS-Free (5000ppm) poloxamer 234, potassium nitrate, silica, relief, without added sodium lauryl sulfate (SLS) Toothpaste sodium saccharin, sorbitol, water, xylitol

Manufactured by GC America Inc. Pure water, , CPP-ACP, D-sorbitol, CMC-Na, • For desensitizing Melon, Mint, propylene glycol, silicon dioxide, titanium dioxide, • For pregnant women Strawberry, RECALDENT™ xylitol, phosphoric acid, flavoring, zinc oxide, MI Paste® No No 40g Fluoride Free • For children under six Tutti Frutti, (CPP-ACP) sodium saccharin, ethyl p-hydroxybenzoate, Vanilla , guar gum, propyl • For sensitivity before and after tooth whitening p-hydroxybenzoate, butyl p-hydroxybenzoate • For sensitivity before and after professional cleaning Pure water, glycerol, CPP-ACP, d-sorbitol, CMC-Na, Melon, Mint, • Patients who experience tooth sensitivity 0.20% Sodium propylene glycol, silicon dioxide, titanium dioxide, MI Paste Strawberry, RECALDENT™ • For sensitivity before and after tooth whitening Yes No 40g Fluoride xylitol, phosphoric acid, sodium fluoride, flavoring, Plus® Tutti Frutti, (CPP-ACP) (900ppm) sodium saccharin, ethyl p-hydroxybenzoate, propyl • For sensitivity before and after professional cleaning Vanilla p-hydroxybenzoate, butyl p-hydroxybenzoate • For desensitizing Sodium fluoride, potassium nitrate, pure water, • For hypersensitivity glycerol, CPP-ACP, phosphate, sorbitol, CMC-Na, 0.24% Sodium propylene glycol, silicon dioxide, titanium dioxide, • For remineralization MI Paste® RECALDENT™ Yes Yes 46g Fresh Mint Fluoride xylitol, phosphoric acid, flavoring, methyl salicylate, • For tooth erosion and wear ONE (CPP-ACP) (1100pppm) sodium saccharin, ethyl p-hydroxybenzoate, propyl • For sensitivity from whitening p-hydroxybenzoate, butyl p-hydroxybenzoate, • For preventing caries and white spot lesions sodium-N-lauroyl sarcosinate

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by GlaxoSmithKline • Sensitive teeth relief in 3 days • Helps whiten teeth 0.454% Stannous fluoride, glycerin, PEG-8, hydrated • Helps prevent and remove tooth stains Sensodyne® Mint, Extra Stannous silica, pentasodium triphosphate, flavor, sodium • Freshens breath No Yes 80g No Rapid Relief Fresh Fluoride lauryl sulfate, titanium dioxide, polyacrylic acid, • Mint (1150ppm) cocamidopropyl betaine, sodium saccharin • Protects against cavities • Contains fluoride • Sensitivity relief and lasting sensitivity protection • Helps whiten teeth • Prevents tartar build-up Potassium nitrate, sodium fluoride, water, hydrated Sensodyne® 0.25% Sodium silica, sorbitol, glycerin, pentasodium triphosphate, • Freshens breath 4oz Extra No Yes Mint Fluoride No PEG-8, flavor, titanium dioxide, sodium methyl cocoyl • Sodium lauryl sulfate free (113g) Whitening (1134ppm) taurate, cocamidopropyl betaine, xanthan gum, • Protects against cavities sodium hydroxide, sodium saccharin, • Contains fluoride • Sensitivity relief and lasting sensitivity protection • A dual-abrasive, high-cleaning silica system Potassium nitrate, sodium fluoride, water, (a combination of dental silicas designed 0.25% Sodium hydrated silica, sorbitol, glycerin, pentasodium to offer high-efficiency tooth cleaning) Sensodyne® 4oz No Yes Fresh Fluoride No triphosphate, PEG-8, sodium lauryl sulfate, • The chemical stain removal/stain Deep Clean (113g) (1134ppm) flavor, xanthan gum, sodium hydroxide, prevention action of STP cocamidopropyl betaine, sodium saccharin, blue 1 • The cleaning action of a high-foaming dual- system • Helps whiten teeth • Helps prevent and remove tooth stains Potassium nitrate, sodium fluoride, sorbitol, water, • Freshens breath 0.25% Sodium glycerin, hydrated silica, pentasodium triphosphate, Sensodyne® Mint, Extra • Extra fresh taste No Yes 3oz Fluoride No PEG-8, flavor, titanium dioxide, sodium methyl True White Fresh (1134ppm) cocoyl taurate, cocamidopropyl betaine, xanthan • Sodium lauryl sulfate free gum, sodium hydroxide, sodium saccharin • Protects against cavities • Contains fluoride • Sensitivity relief and lasting sensitivity protection

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by GlaxoSmithKline (continued)

• Helps whiten teeth • Promotes healthy gums • Helps prevent and remove tooth stains 0.454% Stannous fluoride, glycerin, PEG-8, hydrated • Helps prevent gingivitis Sensodyne® 3.4oz Stannous silica, pentasodium triphosphate, flavor, sodium • Helps remove plaque from teeth Complete No Yes Fresh No (96.4g) Fluoride lauryl sulfate, titanium dioxide, polyacrylic acid, Protection • Helps prevent tartar build-up (1100ppm) sodium saccharin, cocamidopropyl betaine • Freshens breath • Protects against cavities • Contains fluoride • Sensitivity relief and lasting sensitivity protection

• Daily repair for sensitive teeth 0.454% Stannous fluoride, glycerin, PEG-8, hydrated • Promotes healthy gums Sensodyne® 3.4oz Mint, Extra Stannous silica, pentasodium triphosphate, sodium lauryl • Freshens breath Repair and No Yes No (96.4g) Fresh Fluoride sulfate, flavor, titanium dioxide, polyacrylic acid, Protect • Protects against cavities (1100ppm) cocamidopropyl betaine, sodium saccharin • Contains fluoride • Sensitivity relief and lasting sensitivity protection

• Protect enamel against the effects of acid erosion • Strengthen and reharden enamel Sensodyne® Potassium nitrate, sodium fluoride, water, sorbitol, 0.25% Sodium • Freshen breath Pronamel 4oz Mint hydrated silica, glycerin, PEG-8, cocamidopropyl No Yes Fluoride No Daily (113g) Essence betaine, flavor, xanthan gum, sodium saccharin, • Provide cavity protection (1134ppm) Protection titanium dioxide, sodium hydroxide • Maintain healthy teeth • Provide sensitivity relief and lasting sensitivity protection

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by Oral Biotech

Mint flavor: Glycerin, hydrogenated hydrolysate, hydroxyapatite, hydroxyethyl cellulose, menthol, polysorbate 20, potassium sorbate, • Low abrasion sodium benzoate, , sodium • Non-staining CariFree® 2oz hydroxide, sodium lauryl sulfate, water, xylitol No No Mint, Grape Fluoride Free Hydroxyapatite • 25% xylitol patent-pending pH+ technology CTx3 Gel (60mL) Grape flavor: Glycerin, hydrogenated starch hydrolysate, hydroxyapatite, hydroxyethyl • Patent-pending HA Nano technology cellulose, artificial flavors, polysorbate 20, • Tray ready potassium sorbate, sodium benzoate, sodium bicarbonate, sodium hydroxide, water, xylitol

Mint flavor: Sodium fluoride, glycerin, hydrated silica, hydrogenated starch hydrolysate (HSH), hydroxyapatite, hydroxyethyl cellulose, menthol, • Low abrasion natural flavors, polysorbate 20, potassium sorbate, saccharin, sodium benzoate, sodium bicarbonate, • Non-staining CariFree® 0.24% Sodium sodium hydroxide, sodium lauryl sulfate, water, xylitol • 25% xylitol 2oz Mint, Citrus, CTX4 Gel No Yes Fluoride Hydroxyapatite • Soothing/moistening for dry mouth patients (57g) Grape Citrus and grape flavors: sodium fluoride, 1100 (1100ppm) glycerin, hydrated silica, hydrogenated starch • Tray ready hydrolysate (HSH), hydroxyapatite, hydroxyethyl • Patent-pending pH+ technology cellulose, natural and artificial flavors, polysorbate 20, potassium sorbate, saccharin, • Patent-pending HA Nano technology sodium benzoate, sodium bicarbonate, sodium hydroxide, sodium lauryl sulfate, water, xylitol

Mint flavor: Sodium fluoride, glycerin, hydrated silica, hydrogenated starch hydrolysate (HSH), hydroxyapatite, hydroxyethyl cellulose, menthol, • Low abrasion natural fFlavors, polysorbate 20, potassium sorbate, • Non-staining saccharin, sodium benzoate, sodium bicarbonate, CariFree® 1.1% Sodium • 25% xylitol 2oz sodium hydroxide, sodium lauryl sulfate, water, xylitol CTX4 Gel Yes Yes Mint, Citrus Fluoride Hydroxyapatite • Soothing/moistening for dry mouth patients (57g) 5000 (5000ppm) Citrus flavor: Sodium fluoride, glycerin, hydrated silica, hydrogenated starch hydrolysate (HSH), • Tray ready hydroxyapatite, hydroxyethyl cellulose, natural and • Patent-pending pH+ technology artificial flavors, polysorbate 20, potassium sorbate, • Patent-pending HA Nano technology saccharin, sodium benzoate, sodium bicarbonate, sodium hydroxide, sodium lauryl sulfate, water, xylitol

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by Premier Dental Products Company • Mild abrasive cleaning to remove Stannous fluoride, glycerin, polyethylene glycol, debris and residual surface stains 0.45% silica, calcium/sodium maleate methyl vinyl ether Enamelon® Amorphous • Mint breeze flavor 4.3oz Stannous copolymer, cocamidopropyl betaine, calcium sulfate, Fluoride No Yes Mint Breeze Calcium • SLS-free (sodium laurel sulfate) (122g) Fluoride poloxamer 407, dimethicone, lauroyl-sarcosine, Toothpaste Phosphate (ACP) (1150ppm) titanium dioxide, flavor, acesulfame K, monosodium • Gluten-free phosphate, sucralose • Dye-free • Triclosan-free

• Aids in the prevention of cavities • Builds increasing protection against painful sensitivity of the teeth of cold, heat, acids, sweets or contact • Helps prevent gingivitis Stannous fluoride, acesulfame K, calcium/sodium • Helps interfere with the harmful effects Enamelon® 0.40% Amorphous maleate methyl vinyl ether copolymer, calcium of plaque associated with gingivitis Preventive 4oz Stannous No No Clean Mint Calcium sulfate, cocamidopropyl betaine, dimethicone, flavors, • Delivers more fluoride uptake to the teeth Treatment (113g) Fluoride Phosphate (ACP) glycerin, lauroyl-sarcosine, monosodium phosphate, Gel (970ppm) • Strengthens teeth better than the poloxamer 407, polyethylene glycol, silica, sucralose 5000ppm F • Promotes remineralization and inhibits demineralization • More protection with less fluoride • Non-abrasive gel and low-abrasive toothpaste • SLS, gluten, and dye-free

Manufactured by Procter & Gamble Stannous fluoride, water, sorbitol, hydrated 0.454% silica, sodium lauryl sulfate, carrageenan, sodium • Treats: plaque, gingivitis, cavities, sensitivity, tartar Crest® 4.6oz Stannous No Yes Clean Mint No gluconate, flavor, xanthan gum, zinc citrate, • Whitens Pro-Health™ (130g) Fluoride stannous chloride, sodium hydroxide, sodium (1150ppm) • Freshens breath saccharin, sucralose, titanium dioxide, blue 1

Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste

3M™ Clinpro™ 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste HIGHLIGHTS OF PRESCRIBING INFORMATION Nursing Mothers Treatment for Overdose of Clinpro 5000 Toothpaste INDICATIONS AND USAGE Prescribing physicians and dentists should consider total fluoride exposure (dental care plus , water and other sources) when prescribing the product for use in women who Ingested Amount for Clinpro 5000 Anti-Cavity Toothpaste is indicated for use as Recommended action to take part of a professional program for the prevention and control are nursing. fluoride dose 10kg (22 pound) child* of dental caries. Pediatric Use Do not induce vomiting. Give 1-2 glasses The primary adverse effects of fluoride are fluorosis of dental enamel and of the skeleton; DOSAGE AND ADMINISTRATION This equals less than of milk and observe for symptoms of these effects occur at exposures below those associated with other adverse health effects. Less than • Use once daily in place of conventional toothpaste unless instructed otherwise by ½ ounce (or less than upset. If symptoms persist more The population most at risk for dental fluorosis is children during the period 5mg/kg a physician or dentist. 3 teaspoons). than a few hours, seek medical attention of tooth formation, i.e. from birth to 8 years of age. For this population, the Institute of • Apply a thin ribbon or pea-sized amount of Clinpro 5000 Anti-Cavity Toothpaste using or contact a control center. a soft-bristled toothbrush and brush teeth for at least two minutes. Medicine (IOM) established Fluoride Upper Limits of intake based on the risk of dental fluorosis. Do not induce vomiting. Give 1-2 glasses • After brushing, adults should expectorate. Children 6 to 16 years of age should expectorate This equals about ½ ounce In populations with permanent dentition, skeletal fluorosis 5mg/kg or more of milk and seek medical attention or and rinse mouth thoroughly with water. (about 1 tablespoon) or more. is the greatest risk from excessive fluoride. For this population contact a poison control center. DOSAGE FORMS AND STRENGTHS the Institute of Medicine established Fluoride Upper Limits based on the risk of skeletal White toothpaste containing 1.1% sodium fluoride 1 Seek immediate medical attention. fluorosis. This equals 1 ounce or 15mg/kg Do not induce vomiting. CONTRAINDICATIONS Population IOM Fluoride Upper Limit ¼ of the tube. Do not use in children under 6 years of age unless recommended by a dentist or physician. Infants 0-6 months old 0.7mg/day Give 1-2 glasses of milk. WARNINGS AND PRECAUTIONS Infants 7-12 months old 0.9mg/day • Do not swallow. Children 1-3 years old 1.3mg/day * The amount to reach the fluoride dose will be proportionately larger with older children • Keep out of reach of children under 6 years of age. Children 4-8 years old 2.2mg/day and adults. A thin ribbon or pea-sized amount of Clinpro 5000 Anti-Cavity Toothpaste Children > 8 years old 10mg/day weighs approximately 0.3 g and contains approximately 1.5 mg of fluoride ion. A 4 oz. tube • Repeated ingestion of high levels of fluoride may cause dental fluorosis. Prescribing physicians and dentists should consider total fluoride exposure (dental care plus contains 564 mg of fluoride ion. ADVERSE REACTIONS food, water and other sources) when prescribing the product for use in children. 1. IOM. Dietary Reference Intakes: The essential guide to nutrient requirements. Allergic reactions and other idiosyncrasies have been rarely reported. Geriatric Use National Academies Press 2006. To report SUSPECTED ADVERSE REACTIONS, contact 3M ESPE Dental Products Division No studies of Clinpro 5000 Anti-Cavity Toothpaste have been conducted to determine Storage at 1-800-634-2249 or www.3MESPE.com, or FDA at 1-800-FDA-1088 or www.fda.gov/ whether subjects aged 65 and over respond differently from younger subjects. This product is designed to be stored and used at room temperature. Do not freeze or medwatch. OVERDOSAGE expose to extreme heat. See outer package for expiration date. USE IN SPECIFIC POPULATIONS Ingestion of large amounts of fluoride may result in abdominal pain, stomach upset, nausea, Manufactured for: Pregnancy vomiting and . These symptoms may occur at overdosages of 5 mg/kg of body 3M ESPE Prescribing physicians and dentists should consider total fluoride exposure (dental care plus weight. Fluoride doses of 16 mg/kg have been fatal. Dental Products food, water and other sources) when prescribing the product for use in pregnant women or St. Paul, MN 55144-1000 USA women who may become pregnant. Revision date: 01/11/2012 Rx Only 3M, ESPE and Clinpro are trademarks of 3M or 3M Deutschland GmbH. © 3M 2013. All rights reserved.

This is a summary of the prescribing information. For complete prescribing information, please visit www.3M.com.

www.3M.com/PreventiveCare

3M Oral Care 3M Canada 2510 Conway Avenue Post Office Box 5757 3M and Clinpro are trademarks of 3M or 3M Deutschland St. Paul, MN 55144-1000 USA London, Ontario N6A 4T1 GmbH. Used under license in Canada. All other trademarks Canada are property of their respective owners. Phone 1-800-634-2249 Web 3M.com/dental Phone 1-888-363-3685 © 3M 2019. All rights reserved.