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Competitive Comparison 3M™ Clinpro™ Toothpaste

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Competitive Comparison 3M™ Clinpro™ Toothpaste Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by 3M • Clinically proven prescription-strength toothpaste • Remineralizes lesions throughout— not just on the surface • Delivers more fluoride to the tooth than other leading brands tested • Contains 1.1.% NaF (5000ppm fluoride ion) Sodium fluoride, water, sorbitol, hydrated silica, 3M™ Clinpro™ Functionalized • Contains tri-calcium phosphate ingredient (TCP), Vanilla Mint, 1.1% Sodium glycerin, polyethylene-polypropylene glycol, 5000 4oz Tricalcium so Clinpro 5000 toothpaste releases a high Yes Yes Spearmint, Fluoride flavor, polyethylene glycol, sodium lauryl sulfate, Anti-Cavity (113g) Phosphate level of fluoride plus calcium and phosphate— Bubble Gum (5000ppm) titanium dioxide, carboxymethyl cellulose, Toothpaste (fTCP) components found naturally in saliva sodium saccharin and tri-calcium phosphate • Gentle cleaning, gentle whitening • Low abrasion • Use once daily in place of a conventional toothpaste • Available in a convenient 4oz flip-top tube (approx. 6-month patient supply) • Strengthens teeth better than leading brands • Lower fluoride, no prescription needed • Exclusive formula protects against cavities Sodium fluoride, water, sorbitol, hydrated silica, 3M™ Clinpro™ Functionalized and helps reverse white spots 0.21% Sodium glycerin, polyethylene-polypropylene glycol, Tooth Crème 4oz Tricalcium • Perfect for patients at moderate or high risk No Yes Vanilla Mint Fluoride flavor, polyethylene glycol, sodium lauryl sulfate, Anti-Cavity (113g) Phosphate of dental cavities (950ppm) titanium dioxide, carboxymethyl cellulose, Toothpaste (fTCP) sodium saccharin and tri-calcium phosphate • Cleans and whitens teeth with low abrasion • Contains fluoride as well as calcium and phosphate, which are components naturally found in saliva Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by Colgate-Palmolive Company Sodium fluoride, fumaric acid, hydrated silica, mica, PEG-12, poloxamer 338, sodium benzoate, Colgate® • Unique liquid gel formula 1.1% Sodium sodium carboxymethylcellulose, sodium lauryl PreviDent® 3.4oz Spearmint, Tricalcium • FluoriGard Technology™ Yes Yes Fluoride sulfate, sodium saccharine, sorbitol, titanium 5000 Booster (100mL) Fruitastic™ Phosphate (5000ppm) dioxide, tricalcium phosphate, water, xanthan gum. • Mild cleaning system with low abrasion Plus Also contains flavor, FD&C blue 1 dye (spearmint • Helps reverse white-spot lesions only), D&C red 33 dye (Fruitastic™ only) • Unique liquid gel formula Sodium fluoride, potassium nitrate, purified water, Colgate® • Contains anti-sensitivity ingredient, 1.1% Sodium hydrated silica, sorbitol, PEG-12, sodium lauryl sulfate, PreviDent® 3.4oz 5% potassium nitrate Yes Yes Mild Mint Fluoride No carrageenan, flavor, poloxamer 407, cocamidopropyl 5000 (100mL) (5000ppm) betaine, sodium saccharin, mica, sodium hydroxide, • Therapeutic decay prevention safe Sensitive titanium dioxide, FD&C blue no.1, D&C Yellow No.10 for exposed root surfaces • Low abrasion level Sodium fluoride, purified water, sorbitol, hydrated silica, PEG-12, tetrapotassium pyrophosphate, sodium Colgate® 1.1% Sodium lauryl sulfate, mint flavor (Spearmint flavor only), • Prescription-strength fluoride toothpaste 1.8oz Spearmint, PreviDent® Yes Yes Fluoride No xanthan gum, sodium benzoate, fruit flavor (Fruitastic™ • Significant remineralization of root caries (51g) Fruitastic™ 5000 Plus (5000ppm) flavor only), sodium saccharin, titanium dioxide • Great-tasting Spearmint and Fruitastic™ (Fruitastic™ flavor only), FD&C Blue #1 (Spearmint flavor only), D&C Red #33 (Fruitastic™ flavor only) • Reverses early root cavities Sodium fluoride, potassium nitrate water, Colgate® • Strengthens teeth and protects against acid wear 1.1% Sodium hydrated silica, sorbitol, PEG-12, sodium lauryl PreviDent® 3.4oz Yes Yes Mint Fluoride No sulfate, carrageenan, flavor, poloxamer 407, • Therapeutic decay prevention safe 5000 Enamel (100mL) (5000ppm) cocamidopropyl betaine, titanium dioxide, for exposed root surfaces Protect sodium saccharin, mica, sodium hydroxide • With clinically proven anti-sensitivity ingredient, 5% potassium nitrate, for effective sensitivity relief Sodium fluoride, water, sorbitol, hydrated silica, propylene glycol, glycerin, PEG-40 hydrogenated Colgate • Unique liquid gel formula 1.1% Sodium castor oil, dipotassium phosphate, poloxamer 407, PreviDent® 3.4oz Soothing • Significant remineralization of root caries Yes Yes Fluoride No flavor, PVM/MA copolymer, xanthan gum, sodium 5000 Dry (100mL) Mint (5000ppm) benzoate, sodium hydroxide, sodium saccharin, • SLS-free formula known to be less irritating Mouth cocamidopropyl betaine, cetylpyridinium chloride, and less likely to cause dryness potassium sorbate, pectin, FD&C Blue No. 1 Colgate® • Clinically proven Gel-Kam® 0.4% Stannous • Safe and effective for hypersensitivity, Fruit and Stannous fluoride, glycerin, Preventive No No 4.3oz Fluoride No caries control and decalcification Berry, Mint hydroxyethylcellulose, flavoring Treatment (1000ppm) • Available in drugstores without a prescription Gel (see pharmacist) Sodium fluoride, purified water, sorbitol solution 70%, hydroxyethylcellulose, pluronic F-127, • Proven clinically effective Colgate® 1.1% Sodium Very Berry, flavor, sodium saccharin, methyl paraben, • Safe for crowns and composite restorations PreviDent® Yes No 2oz Fluoride No Fresh Mint titanium dioxide, propylparaben, certified dyes Brush-on Gel (5000ppm) • Highest concentration of fluoride (FD&C Red #40 in Bing Cherry and Very Berry available for home use flavors, FD&C Blue #1 in Fresh Mint flavor) Information available on competitive websites as of March 2019. Competitive Comparison 3M™ Clinpro™ Toothpaste Fluoride Calcium Rx Is it a Product Size Flavors Type and Phosphate Full Ingredient List Manufacturer’s Claims Required? Toothpaste? Concentration Based Additive Manufactured by Den-Mat Holdings, LLC Mint flavor contains: Sodium fluoride, cellulose gum, D&C Yellow No. 10, FD&C Blue No. 1, flavor, glycerin, mica (and) titanium dioxide, • Inhibition of demineralization and bacterial activity Fluoridex® 1.1% Sodium poloxamer 234, silica, sodium laurel sulfate, 4oz • Prevention and control of dental caries Daily Defense Yes Yes Fruit, Mint Fluoride No sodium saccharin, sorbitol, water, xylitol (112g) • Greater enamel resistance Toothpaste (5000ppm) Fruit flavor contains: Sodium fluoride, cellulose gum, D&C Red No. 33, flavor, glycerin, mica (and) • Enhanced remineralization titanium dioxide, poloxamer 234, silica, sodium laurel sulfate, sodium saccharin, sorbitol, water, xylitol • Offers the same anticaries benefits of the original Fluoridex® Sodium fluoride, cellulose gum, D&C Yellow No. 10, 1.1% Sodium Daily Defense formula, plus silica to help remove Enhanced 4oz FD&C Blue No. 1, flavor, glycerin, mica (and) titanium Yes Yes Clean Mint Fluoride No surface stains without the use of hydrogen peroxide. Whitening (112g) dioxide, poloxamer 234, silica, sodium laurel sulfate, (5000ppm) Toothpaste sodium saccharin, sorbitol, water, xylitol • Prescribe to patients who have recently undergone a whitening treatment, for ongoing shade maintenance Sodium fluoride, cellulose gum, D&C Yellow No. 10, Fluoridex® 1.1% Sodium FD&C Blue No. 1, flavor, glycerin, mica (and) titanium • Combines maximum-strength fluoride to inhibit Sensitivity 4oz Yes Yes Clean Mint Fluoride No dioxide, poloxamer 234, potassium nitrate, silica, caries and enhance remineralization, with Relief (112g) (5000ppm) sodium lauryl sulfate, sodium saccharin, sorbitol, 5% potassium nitrate for sensitivity relief Toothpaste water, xylitol Fluoridex® Sodium fluoride, cellulose gum, cocamidopropyl Sensitivity 1.1% Sodium betaine, D&C Yellow No. 10, FD&C Blue No. 1, • Provides the same maximum-strength fluoride 4oz Relief Yes Yes Clean Mint Fluoride No flavor, glycerin, mica (and) titanium dioxide, protection with 5% potassium nitrate for sensitivity (112g) SLS-Free (5000ppm) poloxamer 234, potassium nitrate, silica, relief, without added sodium lauryl sulfate (SLS) Toothpaste sodium saccharin, sorbitol, water, xylitol Manufactured by GC America Inc. Pure water, glycerol, CPP-ACP, D-sorbitol, CMC-Na, • For desensitizing Melon, Mint, propylene glycol, silicon dioxide, titanium dioxide, • For pregnant women Strawberry, RECALDENT™ xylitol, phosphoric acid, flavoring, zinc oxide, MI Paste® No No 40g Fluoride Free • For children under six Tutti Frutti, (CPP-ACP) sodium saccharin, ethyl p-hydroxybenzoate, Vanilla magnesium oxide, guar gum, propyl • For sensitivity before and after tooth whitening p-hydroxybenzoate, butyl p-hydroxybenzoate • For sensitivity before and after professional cleaning Pure water, glycerol, CPP-ACP, d-sorbitol, CMC-Na, Melon, Mint, • Patients who experience tooth sensitivity 0.20% Sodium propylene glycol, silicon dioxide, titanium dioxide, MI Paste Strawberry, RECALDENT™ • For sensitivity before and after tooth whitening Yes No 40g Fluoride xylitol, phosphoric acid, sodium fluoride, flavoring, Plus® Tutti Frutti, (CPP-ACP) (900ppm) sodium saccharin, ethyl p-hydroxybenzoate, propyl • For sensitivity before and after
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  • WO 2016/095083 Al O

    WO 2016/095083 Al O

    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/095083 Al 23 June 2016 (23.06.2016) P O P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 8/20 (2006.01) A61K 8/19 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K /27 (2006.01) A61Q 11/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) Number: International Application DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/CN2014/093826 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 15 December 2014 (15. 12.2014) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: COLGATE-PALMOLIVE COMPANY (84) Designated States (unless otherwise indicated, for every [US/US]; 300 Park Avenue, New York 10022 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventor; and TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant (for SC only): XV, Yun [US/CN]; 338 Qingni- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, an Road, Xingang Huangpu, GETDD, Guangzhou, Guang DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, dong 510730 (CN).