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Teratology Primer Birth Defects Research LOGY SO to C a IE R T

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Teratology Primer Birth Defects Research LOGY SO to C a IE R T Teratology Primer Birth Defects Research LOGY SO TO C A IE R T E Y T B Education i r h t c h r a de se fects re Prevention Authors Teratology Primer Sura Alwan F. Clarke Fraser Department of Medical Genetics Professor Emeritus of Human Genetics University of British Columbia McGill University Vancouver, BC V6H 3N1 Canada Montreal, QC H3A 1B1 Canada E-mail: [email protected] E-mail: [email protected] Steven B. Bleyl Jan M. Friedman Department of Pediatrics University of British Columbia University of Utah School of Medicine C.201 BCCH-Shoughnessy Site Salt Lake City, UT 84132-0001 USA 4500 Oak Street E-mail: [email protected] Vancouver, BC V6H 3N1 Canada E-mail: [email protected] Robert L. Brent Thomas Jefferson University Adriane Fugh-Berman Alfred I. duPont Hospital for Children Department of Physiology and Biophysics P.O. Box 269 Georgetown University Medical Center Wilmington, DE 19899 USA Box 571460 E-mail: [email protected] Washington, DC 20057-1460 USA E-mail: [email protected] Christina D. Chambers Departments of Pediatrics and Family and John M. Graham, Jr. Preventive Medicine Director of Clinical Genetics and Dysmorphology University of California at San Diego Cedars Sinai Medical Center School of Medicine 8700 Beverly Blvd., PACT Suite 400 9500 Gilman Dr., Mail Code 0828 Los Angeles, CA 90048 USA La Jolla, CA 92093-0828 USA E-mail: [email protected] E-mail: [email protected] Barbara F. Hales* George P. Daston Department Pharmacology and Therapeutics Procter & Gamble Company McGill University Miami Valley Laboratories 3655 Prom. Sir-William-Osler P.O. Box 538707 Montreal, QC H3G 1Y6 Canada Cincinnati, OH 45253 USA E-mail: [email protected] E-mail: [email protected] Deborah K. Hansen Elaine M. Faustman National Center for Toxicological Research Institute for Risk Analysis and Risk Communication Food and Drug Administration School of Public Health Jefferson, AR 72079-9502 USA Department of Environmental and E-mail: [email protected] Occupational Health Sciences University of Washington Lewis B. Holmes 4225 Roosevelt Way NE, #100 Genetics Unit Seattle, WA 98105-6099 USA Mass General Hospital for Children E-mail: [email protected] 175 Cambridge Street, 504 Boston, MA 02114 USA Richard H. Finnell E-mail: [email protected] Institute of Biosciences and Technology Center for Environmental and Genetic Medicine Ronald D. Hood Texas A&M University Ronald D. Hood & Associates 2121 W. Holcombe Blvd. Toxicology Consultants Houston, TX 77030 USA Box 870344 E-mail: [email protected] Tuscaloosa, AL 35487-0344 USA E-mail: [email protected] i Authors Teratology Primer Robert J. Kavlock Sonja A. Rasmussen National Center for Computational Toxicology National Center on Birth Defects and Office of Research and Development Developmental Disabilities U.S. Environmental Protection Agency Centers for Disease Control and Prevention Research Triangle Park, NC 27711 USA Atlanta, GA 30333 USA E-mail: [email protected] E-mail: [email protected] Thomas B. Knudsen Bernard Robaire National Center for Computational Toxicology (B205-01) Department of Pharmacology and Therapeutics Office of Research and Development McGill University U.S. Environmental Protection Agency 3655 Prom. Sir William Osler Research Triangle Park, NC 27711 USA Montreal, QC H3G 1Y6 Canada Email: [email protected] E-mail: [email protected] Joseph Lary John M. Rogers U.S. Centers for Disease Control & Prevention Toxicity Assessment Division Birth Defects and Genetic Diseases National Health and Environmental Effects 4770 Buford Highway, MS F-45 Research Laboratory Atlanta, GA 30341-3724 USA Office of Research and Development E-mail: [email protected] U.S. Environmental Protection Agency Research Triangle Park, NC 27711 USA Donald R. Mattison E-mail: [email protected] National Institutes of Health Eunice Kennedy Shriver Gary C. Schoenwolf National Institute of Child Health and Human Development Department of Neurobiology and Anatomy 31 Center Drive, Room 1B44 MSC 2085 Director, Children’s Health Research Center Bethesda, MD 20892 USA University of Utah School of Medicine E-mail: [email protected] Salt Lake City, Utah 84132-3401 USA E-mail: [email protected] Richard K. Miller University of Rochester School of Medicine and Dentistry Anthony R. Scialli* Department of Obstetrics and Gynecology Tetra Tech Sciences 601 Elmwood Avenue 2200 Wilson Blvd., Suite 400 Rochester, NY 14642-8668 USA Arlington VA 22201-3397 USA E-mail: [email protected] E-mail: [email protected] James L. Mills Gary M. Shaw National Institutes of Health Stanford University School of Medicine Epidemiology Branch Department of Pediatrics Eunice Kennedy Shriver Division of Neonatal and Developmental Medicine National Institute of Child Health and Human Development Palo Alto, CA 94305 USA Bethesda, MD 20892 USA E-mail: [email protected] E-mail: [email protected] Amar V. Singh Janine E. Polifka Lockheed Martin Contractor University of Washington National Center for Computational Toxicology TERIS U.S. Environmental Protection Agency Box 357920 Research Triangle Park NC 27711 USA Seattle, WA 98195-7920 USA E-mail: [email protected] E-mail: [email protected] ii Authors Teratology Primer William Slikker, Jr. Janet Uriu-Adams Director, National Center for Toxicological Research University of California, Davis Food and Drug Administration Department of Nutrition 3900 NCTR Drive Meyer Hall Jefferson, AR 72079 USA One Shields Avenue E-mail: [email protected] Davis, CA 95616 USA E-mail: [email protected] Ann P. Streissguth Department of Psychiatry and Behavioral Sciences Charles V. Vorhees University of Washington School of Medicine Division of Neurology (MLC 7044) Box 359112 Cincinnati Children’s Research Foundation Seattle, WA 98195-9112 USA Department of Pediatrics E-mail: [email protected]. University of Cincinnati College of Medicine 3333 Burnet Avenue Melissa S. Tassinari* Cincinnati, OH 45229-3039 USA U.S. Food and Drug Administration E-mail: [email protected] CDER/OND Pediatric and Maternal Health Staff Elora J. Weringer W022, Rm 6423 Consultant 10903 New Hampshire Avenue North Stonington, CT 06359 USA Silver Spring, MD 20993 USA E-mail: [email protected] E-mail: [email protected] * Co-Editor iii Acknowledgements Teratology Primer Thanks to all of the authors, contributors, and reviewers for their time, effort, and interest in creating a Teratology Primer some Web sites of Interest Site Name URL Teratology Society http://www.teratology.org Organization of Teratology Information Specialists (OTIS) http://www.otispregnancy.org/ Neurobehavioral Teratology Society (NBTS) http://www.nbts.org/ American College of Toxicology http://www.actox.org/ Canadian Congenital Anomalies Surveillance Network (CCASN) http://www.phac-aspc.gc.ca/ccasn-rcsac/index-eng.php Canadian Institutes of Health Research (CIHR) http://www.cihr-irsc.gc.ca/e/8688.html Institute of Human Development, Child and Youth Health (IHDCYH) Centers for Disease Control and Prevention http://www.cdc.gov/ DevTox—A Resource for Developmental Toxicology http://www.devtox.org/ Eunice Kennedy Shriver National Institute of Child Health http://www.nichd.nih.gov/ and Human Development (NICHD) European Medicines Agency (EMA) http://www.ema.europa.eu/home.htm European Teratology Society http://www.etsoc.com/ FASEB—Federation of American Societies for Experimental Biology http://www.faseb.org/ Fetal Alcohol and Drug Unit, University of Washington-School of Medicine http://depts.washington.edu/fadu/ Gene Interactions http://www.biocarta.com/genes/index.asp International Conference on Harmonization (ICH) guidelines http://www.ich.org/cache/compo/276-254-1.html International Federation of Placenta Associations http://www.epineux.com/IFPA/home/home.html Japanese Teratology Society http://jts.umin.jp/newpage2.html March of Dimes http://www.marchofdimes.com/ MedPedia http://www.medpedia.com/ Mendelian Inheritance in Man http://www.ncbi.nlm.nih.gov/omim Middle Atlantic Reproduction and Teratology Association (MARTA) http://www.e-marta.org/ Mouse Atlas http://genex.hgu.mrc.ac.uk/ National Birth Defects Prevention Network (NBDPN) http://www.nbdpn.org/ National Center for Biotechnology Information (NCBI) http://www.ncbi.nlm.nih.gov/ National Center for Environmental Health/Agency for http://www.atsdr.cdc.gov/ Toxic Substances and Disease Registry (NCEH/ATSDR) National Institute of Environmental Health Sciences (NIEHS) http://www.niehs.nih.gov/ National Institutes of Health (NIH) http://www.nih.gov/ National Institutes of Health (NIH) Office of Rare Diseases http://rarediseases.info.nih.gov/ National Library of Medicine http://www.nlm.nih.gov/ PubMed/MEDLINE http://www.ncbi.nlm.nih.gov/pubmed/ REPROTOX http://reprotox.org Society for Developmental Biology (SDB) http://www.sdbonline.org/ Society for the Study of Reproduction (SSR) http://www.ssr.org/ Society of Toxicology (SOT) http://www.toxicology.org/ TERIS http://depts.washington.edu/terisweb/teris/ Thalidomide Victims Association of Canada http://www.thalidomide.ca/home/ The Hospital for Sick Children (Sick Kids) http://www.sickkids.ca/AboutSickKids/who-we-are/index.html The Multi-dimensional Human Embryo http://embryo.soad.umich.edu/ TOXNET http://toxnet.nlm.nih.gov/ U.S. Environmental Protection Agency (EPA) http://www.epa.gov/ U.S. Food and Drug Administration (FDA) http://www.fda.gov/ Vaccines and Medications in Pregnancy Surveillance System (VAMPSS)
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