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Hot Off the Press EMBL’S Scientific Productivity Is Rising with the Temperature, with Developments and Discoveries Coming Thick and Fast

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Hot Off the Press EMBL’S Scientific Productivity Is Rising with the Temperature, with Developments and Discoveries Coming Thick and Fast The Newsletter of the European Molecular Biology Laboratory EMBL Issue 69 • June 2012 • www.embl.org/newsletter etcetera Hot off the press EMBL’s scientific productivity is rising with the temperature, with developments and discoveries coming thick and fast Ground breaking The earth moved for EMBL-EBI on 13 June, when Director Janet Thornton Atlas of RNA-binding proteins, page 4 took to the wheel of a digger to officially begin construction of a new Technical Hub on the Genome Campus. The new facility, which will house some 200 staff, has been made possible by a £75m grant from the UK govern- ment for the expansion of EMBL-EBI and in support of its role in ELIXIR, the nascent research infrastructure for life science data. See page 3 Shell-shocked scientists, page 4 Locating the brain’s ground zero, page 5 The big question Scientists from across EMBL’s five sites give their views on the questions they would most like answered in modern biology... What makes humans human? How do cells sense where they should go? When will we map the entire human proteome? Some questions are currently beyond even the finest minds on the planet, but that doesn’t stop EMBL’s scientists wanting to find the answer. Learn about the questions occupying thoughts and daydreams in the lab. Find out Read more more on onpage page 6 7 Butterfly’s Fingers Xed for Putting alumni Top tips from genetic project proposal on the map Grants Services 6 secrets 2 8 10 Light at the end of the tunnel XFEL issues a Call for Expressions MAR of Interest for 2011 The dream of an integrated Biology Infrastructure Life Science Facility at contributing to the the European XFEL project in Hamburg is one step closer to realisation. European XFEL Victor Lamzin, deputy head of EMBL Ham- “The use of XFEL will revolutionise the In cooperation with the XFEL burg, is coordinating a project to construct, way scientists visualise biological events, at directorate, EMBL – together with collaborating laboratories from Russia, commission, and operate a Biology Infra- the level of large complexes and sub-cellular JUNE Germany, Sweden, and Denmark – 2011 structure Life Science Center (XBI) at the Eu- components, as well as their dynamics and submits an Expression of Interest ropean XFEL project. XFEL – an X-ray Free processes, and will open up a world of new for a biology infrastructure at XFEL Electron Laser currently under construction and exciting research opportunities to the in Hamburg – is a fourth-generation photon biological community,” says Victor. EMBL presents the source with high flux coherent radiation, fine The nature of modern structural biology ex- XBI project to the XFEL pulse structure and peak brilliance orders of periments, and the fragility and short life span SAC. The project is SEPT magnitude higher than that of third genera- of many samples, mean the ability to prepare, warmly received and 2011 tion synchrotrons. analyse, and interpret experiments in im- EMBL is encouraged to submit a full proposal mediate proximity to the XFEL instruments is Taking the initiative essential. The project will develop a dedicated infrastructure to support this. The construction The XBI project was recommended for of the network implementation at the XFEL Council meeting of tunnels, which total nearly 5.8 in June and follows the signing of a Memoran- kilometres in dum of Understanding by EMBL and XFEL in length, is now XFEL © European September 2011 as a basis for future collabora- completed tions. Both institutes are situated on the DESY campus, together with the storage ring PETRA III, the free-electron laser FLASH, the Centre Submission of MAR for Structural Systems Biology (CSSB), and the full XBI project 2012 proposal A conference organised by the Initia- Centre for free-electron laser science (CFEL). tive for Science in Europe (ISE) has EMBL is also collaborating in a complemen- brought leading scientific minds tary project with Henry Chapman (CFEL, “Use of XFEL will DESY), in developing instrumentation for together with policy makers from the revolutionise the way European Commission, European Par- serial femtosecond crystallography and single- particle imaging at XFEL.“The underlying scientists visualise liament and member states to consider biological events” how science policy can better serve the international and inter-institutional activities interests of the scientific community. will make XBI the world’s premier centre in – Victor Lamzin XFEL biological imaging”, Victor adds. Issues discussed at the meeting, which featured participants from EMBL and EMBO, included the The State of things promotion of transnational collabora- tions, calls for understanding of the Collaboration and cooperation were distinct challenges faced by different high on the agenda as EMBL representa- disciplines, and how scientists can be tives visited Iceland and Luxembourg to more effectively involved across all meet with politicians and scientists. stages of the policy making process. In Iceland, a delegation including ISE is an independent platform of Director General Iain Mattaj, Director of learned societies and scientific organisa- EMBL-EBI Janet Thornton, and Director tions, including EMBL, which aims to of International Relations Silke Schum- support all fields of science at a Euro- acher, met with representatives from pean level, and promote the involvement human genetics organisation DeCODE, of scientists in political decision-making. leading data centre Verve Global, and “While more and more different fund- the University of Iceland. They discussed ing schemes emerge at a European level, opportunities for closer involvement one of the key priorities highlighted at in initiatives such as the Nordic-EMBL the meeting is that we need to reduce Partnership for Molecular Medicine, and the complexity of the research funding the European Life Science Infrastructure and the University of Luxembourg. They system for individual researchers,” says for Biological Information (ELIXIR). discussed how interactions between EMBL Wolfgang Eppenschwandtner, executive In Luxembourg, Iain and Silke joined and the Luxembourg scientific community coordinator of ISE. “Bringing together EMBL Unit heads Peer Bork and Lars could be intensified. Two collaborative such high profile people from science Steinmetz in meeting representatives from research projects are to be led by Peer and and policy is an important step in real- the Ministry for Higher Education and Lars together with scientists from the Lux- ising this goal.” Research, the National Research Fund, embourg Centre for Systems Medicine. 2 EMBL&cetera issue 69 • June 2012 ‘Get new ideas for your research’ The EMBO Meeting chairs look ahead to the conference in Nice, 22–25 September What to expect EC: The EMBO Meeting covers a wide range of topics – you can hear some of the very best researchers from Europe and abroad talking about your favourite subject. But it is also an opportunity to hear about different fields, some that you may not be very familiar with, which provides the opportunity to get new ideas for your own research. Personal highlights “Hear from some of the “Oxygen sensing and “Talk to as many JP: The session on oxygen sensing and best researchers from vasculogenesis is a people as you can vasculogenesis – this is a fascinating area. Europe and abroad” fascinating area” about your research” This session features three outstanding – Elena Conti – Jacques Pouysségur – Julie Ahringer speakers: Peter Carmeliet has been prolific in making knock-out mice for various of angiogenesis; Kari Alitalo has identified EC: My personal highlight is the plenary molecules, which has helped to build a and characterised many of the molecules session on RNA biology: Elisa Izaurralde very comprehensive picture of the biology that will stimulate the migration of cells will talk about gene silencing by microRNAs; and the formation of blood capillary David Tollervey will report on how he ap- networks, crucial events that are needed proaches the problem of intricate networks of for angiogenesis; and Anne Eichmann, protein complexes and protein RNA interac- who is fascinated by specialised endothelial tions with the help of mathematical models; cells called tip-cells, and how they lead to and Rob Singer will discuss technologies that vascular patterning. are now used to follow an RNA molecule in living cells at the single molecule level and to JA: The sessions on chromatin and RNA look at dynamics in vivo. Budget commitment biology are going to be real highlights as it’s signals start of ELIXIR an exciting time for these areas of research. Advice for young scientists We are just starting to scratch the surface of JA: Talk to as many people as you can about understanding how chromatin is regulated your research. Science is about discovery, The second meeting of the interim in transcription and other nuclear events, but integral to that is communicating your ELIXIR Board delivered an important and also in trying to understand how RNA findings to others; bring a poster and talk step in realising the project, as repre- is regulated in post-transcriptional and to people at and outside of poster sessions. sentatives from member states voted transcriptional events. www.the-embo-meeting.org unanimously to support the proposed three-year budget. ELIXIR is a pan-European initiative Hinxton hub is ground-breaking to operate a sustainable research infra- structure for managing and safeguard- The sun shone on a ground-breaking Guests at the ceremony included repre- ing biological information in Europe, ceremony in Hinxton on 13 June, when sentatives of Oxford Archaeology East, who with the hub located at EMBL-EBI. To construction of a new building was of- presented an exhibition of artefacts from the date, 11 member states are signatories ficially kicked off by EMBL-EBI Director site discovered over the past 20 years. of a Memorandum of Understanding Janet Thornton, working a digger! Staff to catalyse its implementation; the gathered on the plaza, while senior scien- agreement commits funds calculated tists and funders in hard-hats waited in individually for each of the countries vain for their turn to work the machine.
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