PLOS ONE RESEARCH ARTICLE Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda 1 1,2 3 Philip OrishabaID *, Joan N. Kalyango , Pauline Byakika-Kibwika , Emmanuel Arinaitwe4, Bonnie Wandera4, Thomas Katairo1,4, Wani Muzeyi1, Hildah Tendo Nansikombi1, Alice Nakato1, Tobius Mutabazi1, Moses R. Kamya3,4, Grant Dorsey5, a1111111111 Joaniter I. Nankabirwa1,4 a1111111111 a1111111111 1 Clinical Epidemiology Unit, College of Health Sciences, Makerere University, Kampala, Uganda, a1111111111 2 Department of Pharmacy, College of Health Sciences, Makerere University, Kampala, Uganda, a1111111111 3 Department of Internal Medicine, College of Health Sciences, Makerere University, Kampala, Uganda, 4 Infectious Diseases Research Collaboration, Kampala, Uganda, 5 Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America *
[email protected] OPEN ACCESS Citation: Orishaba P, Kalyango JN, Byakika- Kibwika P, Arinaitwe E, Wandera B, Katairo T, et al. Abstract (2020) Increased malaria parasitaemia among adults living with HIV who have discontinued Background cotrimoxazole prophylaxis in Kitgum district, Uganda. PLoS ONE 15(11): e0240838. https://doi. Although WHO recommends cotrimoxazole (CTX) discontinuation among HIV patients who org/10.1371/journal.pone.0240838 have undergone immune recovery and are living in areas of low prevalence of malaria, Editor: Ana Paula Arez, Universidade Nova de some countries including Uganda recommend CTX discontinuation despite having a high Lisboa Instituto de Higiene e Medicina Tropical, malaria burden. We estimated the prevalence and factors associated with malaria parasi- PORTUGAL taemia among adults living with HIV attending hospital outpatient clinic before and after dis- Received: May 30, 2020 continuation of CTX prophylaxis.