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Infected ART Naïve Patients at Mulago Hospital
Kiggundu et al. BMC Nephrology (2020) 21:440 https://doi.org/10.1186/s12882-020-02091-2 RESEARCH ARTICLE Open Access Prevalence of microalbuminuria and associated factors among HIV − infected ART naïve patients at Mulago hospital: a cross-sectional study in Uganda Thomas Kiggundu1,2* , Robert Kalyesubula1,3, Irene Andia-Biraro1, Gyaviira Makanga1,4 and Pauline Byakika-Kibwika1,5 Abstract Background: HIV infection affects multiple organs and the kidney is a common target making renal disease, one of the recognized complications. Microalbuminuria represents an early, important marker of kidney damage in several populations including HIV-infected antiretroviral therapy (ART) naïve patients. Early detection of microalbuminuria is critical to slowing down progression to chronic kidney disease (CKD) in HIV-infected patients, however, the burden of microalbuminuria in HIV-infected antiretroviral therapy (ART) naïve patients in Uganda is unclear. Methods: A cross-sectional study was conducted in the Mulago Immune suppression syndrome (ISS) clinic among adult HIV − infected ART naïve outpatients. Data on patient demographics, medical history was collected. Physical examination was performed to assess body mass index (BMI) and hypertension. A single spot morning urine sample from each participant was analysed for microalbuminuria using spectrophotometry and colorimetry. Microalbuminuria was defined by a urine albumin creatinine ratio (UACR) 30-299 mg/g and macroalbuminuria by a UACR > 300 mg/g. To assess the factors associated with microalbuminuria, chi-square, Fisher’s exact test, quantile regression and logistic regression were used. Results: A total of 185 adult participants were consecutively enrolled with median age and CD4+ counts of 33(IQR = 28–40) years and 428 (IQR = 145–689) cells/μL respectively. -
Pauline-Byakika-Kwibwika-Idi-Res1.Pdf (480.3Kb)
SAGE-Hindawi Access to Research Malaria Research and Treatment Volume 2011, Article ID 703730, 5 pages doi:10.4061/2011/703730 Review Article Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals Pauline Byakika-Kibwika,1, 2 Mohammed Lamorde,1, 2 Harriet Mayanja-Kizza,1 Saye Khoo,3 Concepta Merry,1, 2 and Jean-Pierre Van geertruyden4 1 Infectious Diseases Institute and Infectious Diseases Network for Treatment and Research in Africa (INTERACT), Makerere University College of Health Sciences, P.O. Box 7061, Kampala, Uganda 2 Department of Pharmacology and Therapeutics, Trinity College Dublin 2, Ireland 3 Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK 4 International Health, Epidemiology en Social Medicine, Universiteit Antwerpen, Universiteitsplein 1, 2610 Antwerp, Belgium Correspondence should be addressed to Pauline Byakika-Kibwika, [email protected] Received 14 December 2010; Accepted 14 February 2011 Academic Editor: Neena Valecha Copyright © 2011 Pauline Byakika-Kibwika et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemether- lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria. The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment. -
DISSERTATION___Louis Nyende.Pdf
MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES PREVALENCE AND FACTORS ASSOCIATED WITH RENAL DYSFUNCTION AMONG HIV INFECTED PATIENTS RECEIVING TENOFOVIR AT MULAGO COMMUNICABLE DISEASE CLINIC. BY DR. LOUIS NYENDE, MBChB (MUK) REG NO 2015/HD07/1323U SUPERVISORS: 1. ASSOCIATE PROF PAULINE BYAKIKA-KIBWIKA (MBChB, MSc, MMed, PHD) 2. Dr. EMMANUEL SEKASANVU (MBChB, MMed, FISN) 3. Dr. KALYESUBULA ROBERT (MBChB, MMed, FISN) RESEARCH DISSERTATION SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF A DEGREE OF MASTERS OF MEDICINE IN INTERNAL MEDICINE OF MAKERERE UNIVERSITY KAMPALA ©APRIL 2018 i DEDICATION I dedicate this work to my lovely wife Susan; and our dear children Louise, Leticia (RIP), Lisa and Blessing. ii ACKNOWLEDGEMENTS Special thanks go to my supervisors, Assoc. Professor Pauline Byakika, Dr. Emmanuel Sekasanvu and Dr. Robert Kalyesubula for their continued advice and guidance. I am also very grateful to the following: Prof. Moses Kamya, Prof Harriet Mayanja and Dr. Deo Wabwire for inspiring me to do internal medicine Dr. Gyaviira Makanga for the advice, guidance and editing Mr. Kalibaala Dennis for the statistical work Mulago-KCCA project for the scholarship award to cater for tuition and functional fees RASHOTS CKD project for the research grant award Apollo Muramuzi,MaryNamuli, Nalongo Irene and the staff of Kiruddu -Mulago hospital infectious diseases Clinic for their assistance in the data collection All the patients attending the Infectious diseases clinic in Mulago communicable disease clinic who voluntarily consented to participate in this study, thank you for accepting to be part of this study. My classmates- Katuramu,Iraguha,Owachi,Okello,Baluku,Mubangizi,Nakidde,Nakagayi & Namukasa for making MMed memorable. -
High CD56 CD16 Natural Killer (NK) 14
Bayigga et al. BMC Immunology 2014, 15:2 http://www.biomedcentral.com/1471-2172/15/2 RESEARCH ARTICLE Open Access High CD56++CD16- natural killer (NK) cells among suboptimal immune responders after four years of suppressive antiretroviral therapy in an African adult HIV treatment cohort Lois Bayigga1, Rose Nabatanzi1, Prossy Naluyima Sekiziyivu2, Harriet Mayanja-Kizza3, Moses R Kamya3, Andrew Kambugu4, Joseph Olobo1, Agnes Kiragga4, Sam Kirimunda1, Moses Joloba1 and Damalie Nakanjako3,4* Abstract Background: Up to 40% of HIV-infected individuals receiving Highly Active Antiretroviral Therapy (HAART) have poor CD4+ T-cell recovery. The role of natural killer (NK) cells in immune recovery during HAART is not well understood. We described the profiles of NK cell subsets and their expression of activating receptor, NKG2D and cytotoxicity receptor NKp46 among suboptimal immune responders to despite four years of suppressive HAART. Methods: A case control study utilized frozen peripheral blood mononuclear cells (PBMC) from a cohort of HIV-infected adults that initiated HAART in 2004/5, at CD4 < 200 cells/μl. Cases were ‘suboptimal’ responders; patients within the lowest quartile of CD4+ T-cell reconstitution, with a median CD4 count increase of 129 (-43-199) cells/μl (difference between CD4 count at baseline and after 4 years of HAART) and controls were ‘super-optimal’ responders; patients within the highest quartile of CD4 T-cell reconstitution with a median CD4 count increase of 528 (416-878) cells/μl). Expression of NK cell lineage markers (CD56+/-CD16+/-) and receptors NKG2D and NKp46, was measured among PBMC from 29 cases of ‘suboptimal’ responders’ and 23 controls of ‘super-optimal responders’,and compared among ‘suboptimal’ and ‘super-optimal’ responders. -
JCRC at 25 Years Magazine
JCRC@25 The birth, growth and evolution of the centre A successful journey that started 25 years ago Testimonies from the beneficiaries What the partners say JCRC @25 Contents eDiToR: Conan Businge Messages (Conan Events Co Ltd) Message from Chairman Board 4 Message from Executive Director 6 DeSign & LAYoUT Diana Kambedha Carol Kabega Features JCRC’s 25-year journey 10 Abou Kisige A story of success and great sacrifice 11 Courtesy Photos cooRDinAToR Fred Byaruhanga Profiles JcRc Board members of the years 8 coMMUnicATionS TeAM 12 Christine Matama Senior management All rights reserved. ©2016 Pictorial Reproduction in whole or in part without written permission is strictly Around JCRC 25 prohibited. JCRC, Plot 101, Lubowa E s t a t e s , O ff E n t e b b e R o a d Partners P.O. Box 10005, Kampala, Uganda UK Medical research Council Tel: 256-414-201147/48 Clinical Trail Unit 31 Fax: 256-414-342632 E-Mail: [email protected] Website: http://www.jcrc.co.ug Interviews With Dr James Makumbi 32 With Dr Justine Jita 33 Research JCRC publications 36 JCRC @25 2 JCRC @25 Contents eDiToR: Conan Businge Messages (Conan Events Co Ltd) Message from Chairman Board 4 Message from Executive Director 6 DeSign & LAYoUT Diana Kambedha Carol Kabega Features JCRC’s 25-year journey 10 Abou Kisige A story of success and great sacrifice 11 Courtesy Photos cooRDinAToR Fred Byaruhanga Profiles JcRc Board members of the years 8 coMMUnicATionS TeAM 12 Christine Matama Senior management All rights reserved. ©2016 Pictorial Reproduction in whole or in part without written permission is strictly Around JCRC 25 prohibited. -
A Media Handbook for HIV Vaccine Trials for Africa Acknowledgements
A Media Handbook for HIV Vaccine Trials for Africa Acknowledgements The Media Handbook for HIV Vaccine Trials for Africa was written by Yinka Adeyemi with guidance and direction from Bunmi Makinwa of the department of Policy, Strategy and Research, Dr Jose Esparza, Dr Saladin Osmanov, Claire Pattou, and Coumba Touré of the World Health Organization (WHO)/Joint United Nations Programme on HIV/AIDS (UNAIDS), HIV Vaccine Initiative. We would like to acknowledge the following individuals for their valuable comments and contributions to this handbook: Dr Alashle Abimiku, Dr Omu Anzala, Dr Carlos Arnaldo, Dr Courtney Batholomew, Janet Frohlich, Dr D. A. Gangakhedar, Dr Rodney Hoff. Patrick Jabani, Bachi Karkaria, Dr Tom LaSalvia, Dr Chewe Luo, Nebat Mbewe, Dr Rosemary Musonda, Binod Mahanty, Dr Roy Mugerwa, Ronaldo Mussauer de Lima, Omololu Falobi, Otula Owuor, Kirk Pereira, Dr John Rwomushana, Mario Scheffer, Jaya Shreedhar, Judith Soal, Dr Prasert Thongcharoen, Kathy Ann Waterman and Victor Zonana. The section on Communication and vaccine trials in Thailand (Appendix 1) is based on a UNAIDS report by Nusara Thaitawat, while that on Communication issues in vaccine trials in Uganda (Appendix 2) is based on a UNAIDS report by Ann Fieldler. The section on Communication and preparations for HIV vaccine trials in Kenya (Appendix 3) is by Otula Owuor. A number of fictitious people and organizations are used for illustrative purposes within the text. Any reference to actual persons or organizations is purely coincidental. UNAIDS/01.05E (English original, February 2001) ISBN 92-9173-021-1 © Joint United Nations Programme on HIV/AIDS The designations employed and the presentation of the (UNAIDS) 2001. -
Career Development for Infection and Immunity Research in Uganda
AAS Open Research AAS Open Research 2020, 3:26 Last updated: 02 JUL 2020 RESEARCH ARTICLE Career development for infection and immunity research in Uganda: a decade of experience from the Makerere University – Uganda Virus Research Institute research and training programme [version 1; peer review: 1 approved] Damalie Nakanjako 1,2, Flavia Zalwango3, Pamela Wairagala3, Fiona Luboga1, Irene Andia Biraro 1,2, Victoria Diana Bukirwa1, Mary Gorrethy Mboowa1, Steve Cose1,3, Janet Seeley 3,4, Alison Elliott 1,3 1Makerere University-Uganda Virus Research Institute Infection and Immunity (MUII), Uganda Virus Research Institute, Entebbe, Uganda 2Department of Medicine, School of Medicine, Makerere University, College of Health Sciences, Kampala, Uganda 3Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit,, Uganda Virus Research Institute, Entebbe, Uganda 4Global Health and Development Department, London School of Hygiene and Tropical Medicine, London, UK First published: 24 Jun 2020, 3:26 Open Peer Review v1 https://doi.org/10.12688/aasopenres.13066.1 Latest published: 24 Jun 2020, 3:26 https://doi.org/10.12688/aasopenres.13066.1 Reviewer Status Abstract Invited Reviewers Background: The Makerere University/Uganda Virus Research Institute 1 (UVRI) Centre of Excellence for Infection & Immunity Research and Training (MUII) is a collaborative programme supporting excellence in version 1 Infection and Immunity (I&I) research in Uganda. Set up in 2008, MUII aims 24 Jun 2020 report to produce internationally competitive Ugandan and East African I&I research leaders, and develop human and infrastructural resources to support research and training excellence. We undertook an internal evaluation of MUII’s achievements, challenges and lessons learned 1 Yohana Mashalla , University of Botswana, between August 2008 and December 2019, to inform programmes seeking Gaborone, Botswana to build Africa’s health research expertise. -
Serena Hotel and Conference Centre Kampala, Uganda May 26–27, 2011 Table of Contents
Program Serena Hotel and Conference Centre Kampala, Uganda MAY 26–27, 2011 Table of Contents Welcome Letter . 3 Acknowledgements . 4 General Information . 5 Agenda . 9 u Wednesday, May 25, 2011 . 9 u Thursday, May 26, 2011 . 9 u Friday, May 27, 2011 . .11 Conference Centre Floor Plan . 13 Abstracts . 14 Attendee List . 38 Attendee Collaboration Information . 47 SUB-SAHARAN AFRICA CFAR CONFERENCE 2011 1 Dear CFAR Colleagues and Partners! On behalf of the U .S . National Institutes of Health-sponsored Centers for AIDS Research, and Makerere University’s Infectious Diseases Institute, welcome to Kampala! It is our pleasure and honor to have you join us for the 2011 Sub-Saharan Africa CFAR Conference as we gather to feature some of the important research being conducted by African investigators collaborating with the 21 Centers for AIDS Research (CFARs) . Our Conference Steering Committee is planning an exciting program focusing on three priority themes: u Integrating Treatment and Prevention in HIV Care u HIV Comorbidities u HIV and Women Through a combination of plenary and poster presentations, panel discussions, and networking sessions, this meeting will present a unique opportunity for both scientific and information exchange . A special effort will be made to provide a platform for sharing information on existing scientific resources and infrastructure at leading African institutions that support AIDS research and training – a critical prerequisite for the exchange of scientific resources, capacity building, and the fostering of new collaborations among African institutions . The conference has already generated much energy and interest . We envision this momentum leading to the emergence of an African-led network that will build on existing collaborations and begin to explore potential synergies with new partners – including other CFARs, other complementary networks active in Africa, and in particular, South-South partnerships among African institutions – to strengthen the community of science on the continent . -
Scientific Considerations for the Regulation and Clinical Evaluation of HIV/AIDS Preventive Vaccines
WHO–UNAIDS REPORT Scientific considerations for the regulation and clinical evaluation of HIV/AIDS preventive vaccines Reportà from a WHO-UNAIDS Consultation 13–15 March 2001, Geneva, Switzerland The consultation was jointly organized by the WHO-UNAIDS HIV Vaccine Initiative and the Quality Assurance and Safety of Biologicals Team of the World Health Organization (WHO). Thirty-four experts from 16 developed and developing countries attended the meeting, bringing together expertise from academic institutions, clinical trial centres, national and international regulatory authorities. Representatives of major pharmaceutical companies were also invited. The primary objective of the meeting was to identify gaps that need to be addressed from regulatory perspective to ensure appropriate progress of HIV vaccine develop- ment from basic research to human trials, licensing and future application, with a special focus on needs of developing countries. As a result of discussions, the following priority needs were identified and recommen- dations were made in order to establish an appropriate regulatory framework for the development and evaluation of preventive HIV/AIDS vaccines, which were divided in two main areas: (a) standardization and control of candidate HIV/AIDS vaccines, and (b) approaches to the conduct of clinical trials of candidate HIV/AIDS vaccines.& 2002 Lippincott Williams & Wilkins AIDS 2002, 16:W15–W25 Keywords: HIV/AIDS vaccines, product development, clinical trials, regulatory requirements Introduction the best hope of prevention -
HIV/AIDS and Governance in Uganda and Senegal’ P.I
James Putzel, ‘HIV/AIDS and Governance in Uganda and Senegal’ p.i Institutionalising an Emergency Response: HIV/AIDS and Governance in Uganda and Senegal1 A report submitted to the Department for International Development May 2003 Dr. James Putzel 1 All comments would be welcome by the author: [email protected]. I would like to thank all those in Uganda and Senegal who spared valuable time to meet with me and steer me towards important documentation. I would like to thank all those who provided comments and criticisms on earlier drafts including Tim Allen, Tony Barnett, Charles Becker, Victoria Brittain, Ben Dickson, Garth Glentworth, Julian Lambert, F. Golooba Mutebi, Ken Shadlen, Angela Spilsbury, Sue Unsworth and Alan Whiteside. I am especially grateful to Sarah Hearn for both comments and support throughout this study. Since I have accepted some suggestions and rejected others, I assume full responsibility for what appears in the following pages. James Putzel, ‘HIV/AIDS and Governance in Uganda and Senegal’ p.ii Table of contents Executive Summary................................................................................................. iii Acronyms..................................................................................................................vi 1. Introduction............................................................................................................1 1.1 Why was the international community late?....................................................2 1.2 Why look at governance?.................................................................................3 -
Protest UKRI Funding Cuts
18th March 2021 Rt Honourable Dominic Raab, Secretary of State for Foreign, Commonwealth and Development Affairs Rt Hon Rishi Sunak, Chancellor of the Exchequer Dear Mr Raab and Mr Sunak, Subject: Cutting UKRI Funding is unacceptable and counterproductive to UK and global interests We are writing in response to the letter issued by the UKRI on 11th March 2021 informing UK higher education institutions that it would be reducing the allocation to UKRI ‘significantly’ in light of the UK government’s decision to suspend its Official Development Assistance (ODA) commitment to 0.7% of GNI. As people employed in UK academic institutions working on global health and as their research colleagues, partners and collaborators across the globe, we, the undersigned, urge the government to reconsider this decision. The consequences of the decision are far-reaching for the health and wellbeing of some of the poorest, most vulnerable and marginalised members of our global community, and for the creation of the next generation of young researchers in ODA-recipient countries and in the UK, individuals whose skills will be essential if we are to find solutions to the many challenges facing our world. We are of course well aware of the impact of COVID-19 on people and economies, and understand that difficult decisions are having to be made as the UK builds back better and fairer in the coming years. However, we are dismayed that the people likely to suffer most from the decision announced on March 11th are the ultimate beneficiaries of UKRI-funded research programmes - which address some of the world’s most complex and challenging global health problems. -
Croi 2021 Program Committee
General Information CONTENTS WELCOME . 2 General Information General Information OVERVIEW . 2 CONTINUING MEDICAL EDUCATION . 3 CONFERENCE SUPPORT . 4 VIRTUAL PLATFORM . 5 ON-DEMAND CONTENT AND WEBCASTS . 5 CONFERENCE SCHEDULE AT A GLANCE . 6 PRECONFERENCE SESSIONS . 9 LIVE PLENARY, ORAL, AND INTERACTIVE SESSIONS, AND ON-DEMAND SYMPOSIA BY DAY . 11 SCIENCE SPOTLIGHTS™ . 47 SCIENCE SPOTLIGHT™ SESSIONS BY CATEGORY . 109 CROI FOUNDATION . 112 IAS–USA . 112 CROI 2021 PROGRAM COMMITTEE . 113 Scientific Program Committee . 113 Community Liaison Subcommittee . 113 Former Members . 113 EXTERNAL REVIEWERS . .114 SCHOLARSHIP AWARDEES . 114 AFFILIATED OR PROXIMATE ACTIVITIES . 114 EMBARGO POLICIES AND SOCIAL MEDIA . 115 CONFERENCE ETIQUETTE . 115 ABSTRACT PROCESS Scientific Categories . 116 Abstract Content . 117 Presenter Responsibilities . 117 Abstract Review Process . 117 Statistics for Abstracts . 117 Abstracts Related to SARS-CoV-2 and Special Study Populations . 117. INDEX OF SPECIAL STUDY POPULATIONS . 118 INDEX OF PRESENTING AUTHORS . .122 . Version 9 .0 | Last Update on March 8, 2021 Printed in the United States of America . © Copyright 2021 CROI Foundation/IAS–USA . All rights reserved . ISBN #978-1-7320053-4-1 vCROI 2021 1 General Information WELCOME TO vCROI 2021 Welcome to vCROI 2021! The COVID-19 pandemic has changed the world for all of us in so many ways . Over the past year, we have had to put some of our HIV research on hold, learned to do our research in different ways using different tools, to communicate with each other in virtual formats, and to apply the many lessons in HIV research, care, and community advocacy to addressing the COVID-19 pandemic . Scientists and community stakeholders who have long been engaged in the endeavor to end the epidemic of HIV have pivoted to support and inform the unprecedented progress made in battle against SARS-CoV-2 .