Professor Pauline Byakika-Kibwika

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Professor Pauline Byakika-Kibwika Physician and Epidemiologist, and Associate Professor of Internal Medicine at Makerere University College of Health Sciences (MakCHS). She has over twenty years’ experience in clinical care, research, occupational and travel medicine, capacity building, project development and management. Professor Byakika-Kibwika holds a Bachelor of Medicine and Bachelor of Surgery, Master of Science in Clinical Epidemiology and Biostatistics, Master of Medicine in Internal Medicine from Makerere University and a Doctorate from Trinity College, Dublin, Ireland. She is an infectious diseases specialist and accomplished researcher with over 40 publications in peer reviewed journals. She is the Director of Research and heads the Scientific Review Committee at the Department of Medicine. She is a member of the Accreditation Committee for Research Ethics Committees in Uganda, fellow of Uganda Academy of Sciences, and consultant for Ministry of Health and partners for Malaria and HIV/AIDS Control. Professor Byakika-Kibwika is the Company Medical Advisor to the Oil and Gas Industry in Uganda, specifically; Tullow Oil Uganda Pty and TOTAL Exploration and Production, where she established the occupational health and travel medicine service, drafted travel health guidelines and procedures and provides pre and post-travel consultative services, travel kits, immunizations, screening and treatment for occupational and travel related illness. At regional level, Pauline is a Commissioner on the East African Health Research Commission, where she contributes to decision making on health matters, research and evidence for knowledge generation, translation, policy formulations and practice. .

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Infected ART Naïve Patients at Mulago Hospital
Kiggundu et al. BMC Nephrology (2020) 21:440 https://doi.org/10.1186/s12882-020-02091-2 RESEARCH ARTICLE Open Access Prevalence of microalbuminuria and associated factors among HIV − infected ART naïve patients at Mulago hospital: a cross-sectional study in Uganda Thomas Kiggundu1,2* , Robert Kalyesubula1,3, Irene Andia-Biraro1, Gyaviira Makanga1,4 and Pauline Byakika-Kibwika1,5 Abstract Background: HIV infection affects multiple organs and the kidney is a common target making renal disease, one of the recognized complications. Microalbuminuria represents an early, important marker of kidney damage in several populations including HIV-infected antiretroviral therapy (ART) naïve patients. Early detection of microalbuminuria is critical to slowing down progression to chronic kidney disease (CKD) in HIV-infected patients, however, the burden of microalbuminuria in HIV-infected antiretroviral therapy (ART) naïve patients in Uganda is unclear. Methods: A cross-sectional study was conducted in the Mulago Immune suppression syndrome (ISS) clinic among adult HIV − infected ART naïve outpatients. Data on patient demographics, medical history was collected. Physical examination was performed to assess body mass index (BMI) and hypertension. A single spot morning urine sample from each participant was analysed for microalbuminuria using spectrophotometry and colorimetry. Microalbuminuria was defined by a urine albumin creatinine ratio (UACR) 30-299 mg/g and macroalbuminuria by a UACR > 300 mg/g. To assess the factors associated with microalbuminuria, chi-square, Fisher’s exact test, quantile regression and logistic regression were used. Results: A total of 185 adult participants were consecutively enrolled with median age and CD4+ counts of 33(IQR = 28–40) years and 428 (IQR = 145–689) cells/μL respectively.
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Pauline-Byakika-Kwibwika-Idi-Res1.Pdf (480.3Kb)
SAGE-Hindawi Access to Research Malaria Research and Treatment Volume 2011, Article ID 703730, 5 pages doi:10.4061/2011/703730 Review Article Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals Pauline Byakika-Kibwika,1, 2 Mohammed Lamorde,1, 2 Harriet Mayanja-Kizza,1 Saye Khoo,3 Concepta Merry,1, 2 and Jean-Pierre Van geertruyden4 1 Infectious Diseases Institute and Infectious Diseases Network for Treatment and Research in Africa (INTERACT), Makerere University College of Health Sciences, P.O. Box 7061, Kampala, Uganda 2 Department of Pharmacology and Therapeutics, Trinity College Dublin 2, Ireland 3 Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK 4 International Health, Epidemiology en Social Medicine, Universiteit Antwerpen, Universiteitsplein 1, 2610 Antwerp, Belgium Correspondence should be addressed to Pauline Byakika-Kibwika, [email protected] Received 14 December 2010; Accepted 14 February 2011 Academic Editor: Neena Valecha Copyright © 2011 Pauline Byakika-Kibwika et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses signiﬁcant challenges. Artemether- lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria. The drug combination is highly eﬃcacious against sensitive and multidrug resistant falciparum malaria. Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment.
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DISSERTATION___Louis Nyende.Pdf
MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES PREVALENCE AND FACTORS ASSOCIATED WITH RENAL DYSFUNCTION AMONG HIV INFECTED PATIENTS RECEIVING TENOFOVIR AT MULAGO COMMUNICABLE DISEASE CLINIC. BY DR. LOUIS NYENDE, MBChB (MUK) REG NO 2015/HD07/1323U SUPERVISORS: 1. ASSOCIATE PROF PAULINE BYAKIKA-KIBWIKA (MBChB, MSc, MMed, PHD) 2. Dr. EMMANUEL SEKASANVU (MBChB, MMed, FISN) 3. Dr. KALYESUBULA ROBERT (MBChB, MMed, FISN) RESEARCH DISSERTATION SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF A DEGREE OF MASTERS OF MEDICINE IN INTERNAL MEDICINE OF MAKERERE UNIVERSITY KAMPALA ©APRIL 2018 i DEDICATION I dedicate this work to my lovely wife Susan; and our dear children Louise, Leticia (RIP), Lisa and Blessing. ii ACKNOWLEDGEMENTS Special thanks go to my supervisors, Assoc. Professor Pauline Byakika, Dr. Emmanuel Sekasanvu and Dr. Robert Kalyesubula for their continued advice and guidance. I am also very grateful to the following: Prof. Moses Kamya, Prof Harriet Mayanja and Dr. Deo Wabwire for inspiring me to do internal medicine Dr. Gyaviira Makanga for the advice, guidance and editing Mr. Kalibaala Dennis for the statistical work Mulago-KCCA project for the scholarship award to cater for tuition and functional fees RASHOTS CKD project for the research grant award Apollo Muramuzi,MaryNamuli, Nalongo Irene and the staff of Kiruddu -Mulago hospital infectious diseases Clinic for their assistance in the data collection All the patients attending the Infectious diseases clinic in Mulago communicable disease clinic who voluntarily consented to participate in this study, thank you for accepting to be part of this study. My classmates- Katuramu,Iraguha,Owachi,Okello,Baluku,Mubangizi,Nakidde,Nakagayi & Namukasa for making MMed memorable.
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Croi 2021 Program Committee
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Research on Vectors, Environment and Society
Annual Report 2015 Research on Vectors, Environment and Society TDR/VES/16.1 Copyright © World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases 2016 All rights reserved. The use of content from this information product for all non‐commercial education, training and information purposes is encouraged, including translation, quotation and reproduction, in any medium, but the content must not be changed and full acknowledgement of the source must be clearly stated. A copy of any resulting product with such content should be sent to TDR, World Health Organization, Avenue Appia, 1211 Geneva 27, Switzerland. TDR is a World Health Organization (WHO) executed UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases. The use of any information or content whatsoever from it for publicity or advertising, or for any commercial or income‐generating purpose, is strictly prohibited. No elements of this information product, in part or in whole, may be used to promote any specific individual, entity or product, in any manner whatsoever. The designations employed and the presentation of material in this information product, including maps and other illustrative materials, do not imply the expression of any opinion whatsoever on the part of WHO, including TDR, the authors or any parties cooperating in the production, concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delineation of frontiers and borders. Mention or depiction of any specific product or commercial enterprise does not imply endorsement or recommendation by WHO, including TDR, the authors or any parties cooperating in the production, in preference to others of a similar nature not mentioned or depicted.
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Or Intravenous Quinine Plus ACT for Treatment of Severe M
Byakika-Kibwika et al. BMC Infectious Diseases (2017) 17:794 DOI 10.1186/s12879-017-2924-5 RESEARCH ARTICLE Open Access Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial Pauline Byakika-Kibwika1,2* , Jane Achan3, Mohammed Lamorde2, Carine Karera-Gonahasa2, Agnes N. Kiragga2, Harriet Mayanja-Kizza1, Noah Kiwanuka4, Sam Nsobya5, Ambrose O. Talisuna6 and Concepta Merry2,7 Abstract Background: Severe malaria is a medical emergency associated with high mortality. Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by longer acting oral antimalarial drugs for cure and prevention of recrudescence. Methods: In a randomized controlled clinical trial, we evaluated the 42-day parasitological outcomes of severe malaria treatment with intravenous artesunate (AS) or intravenous quinine (QNN) followed by oral artemisinin based combination therapy (ACT) in children living in a high malaria transmission setting in Eastern Uganda. Results: We enrolled 300 participants and all were included in the intention to treat analysis. Baseline characteristics were similar across treatment arms. The median and interquartile range for number of days from baseline to parasite clearance was significantly lower among participants who received intravenous AS (2 (1–2) vs 3 (2–3), P <0. 001). Overall, 63.3% (178/281) of the participants had unadjusted parasitological treatment failure over the 42-day follow-up period. Molecular genotyping to distinguish re-infection from recrudescence was performed in a sample of 127 of the 178 participants, of whom majority 93 (73.2%) had re-infection and 34 (26.8%) had recrudescence.
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Byakika-Kibwika, Pauline
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by LSHTM Research Online Byakika-Kibwika, Pauline; Achan, Jane; Lamorde, Mohammed; Karera- Gonahasa, Carine; Kiragga, Agnes N; Mayanja-Kizza, Harriet; Ki- wanuka, Noah; Nsobya, Sam; Talisuna, Ambrose O; Merry, Concepta (2017) Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial. BMC infectious diseases, 17 (1). 794-. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-017-2924-5 Downloaded from: http://researchonline.lshtm.ac.uk/4651992/ DOI: 10.1186/s12879-017-2924-5 Usage Guidelines Please refer to usage guidelines at http://researchonline.lshtm.ac.uk/policies.html or alterna- tively contact [email protected]. Available under license: http://creativecommons.org/licenses/by/2.5/ Byakika-Kibwika et al. BMC Infectious Diseases (2017) 17:794 DOI 10.1186/s12879-017-2924-5 RESEARCH ARTICLE Open Access Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial Pauline Byakika-Kibwika1,2* , Jane Achan3, Mohammed Lamorde2, Carine Karera-Gonahasa2, Agnes N. Kiragga2, Harriet Mayanja-Kizza1, Noah Kiwanuka4, Sam Nsobya5, Ambrose O. Talisuna6 and Concepta Merry2,7 Abstract Background: Severe malaria is a medical emergency associated with high mortality. Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by longer acting oral antimalarial drugs for cure and prevention of recrudescence. Methods: In a randomized controlled clinical trial, we evaluated the 42-day parasitological outcomes of severe malaria treatment with intravenous artesunate (AS) or intravenous quinine (QNN) followed by oral artemisinin based combination therapy (ACT) in children living in a high malaria transmission setting in Eastern Uganda.
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A Systematic Review Protocol to Establish Plasmodium Falciparum
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Stakeholder Meeting on Co-Infections and Co-Morbidities
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EDCTP2 Portfolio: Fellowship Programme
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Increased Malaria Parasitaemia Among Adults Living with HIV Who Have Discontinued Cotrimoxazole Prophylaxis in Kitgum District, Uganda
PLOS ONE RESEARCH ARTICLE Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda 1 1,2 3 Philip OrishabaID *, Joan N. Kalyango , Pauline Byakika-Kibwika , Emmanuel Arinaitwe4, Bonnie Wandera4, Thomas Katairo1,4, Wani Muzeyi1, Hildah Tendo Nansikombi1, Alice Nakato1, Tobius Mutabazi1, Moses R. Kamya3,4, Grant Dorsey5, a1111111111 Joaniter I. Nankabirwa1,4 a1111111111 a1111111111 1 Clinical Epidemiology Unit, College of Health Sciences, Makerere University, Kampala, Uganda, a1111111111 2 Department of Pharmacy, College of Health Sciences, Makerere University, Kampala, Uganda, a1111111111 3 Department of Internal Medicine, College of Health Sciences, Makerere University, Kampala, Uganda, 4 Infectious Diseases Research Collaboration, Kampala, Uganda, 5 Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America * [email protected] OPEN ACCESS Citation: Orishaba P, Kalyango JN, Byakika- Kibwika P, Arinaitwe E, Wandera B, Katairo T, et al. Abstract (2020) Increased malaria parasitaemia among adults living with HIV who have discontinued Background cotrimoxazole prophylaxis in Kitgum district, Uganda. PLoS ONE 15(11): e0240838. https://doi. Although WHO recommends cotrimoxazole (CTX) discontinuation among HIV patients who org/10.1371/journal.pone.0240838 have undergone immune recovery and are living in areas of low prevalence of malaria, Editor: Ana Paula Arez, Universidade Nova de some countries including Uganda recommend CTX discontinuation despite having a high Lisboa Instituto de Higiene e Medicina Tropical, malaria burden. We estimated the prevalence and factors associated with malaria parasi- PORTUGAL taemia among adults living with HIV attending hospital outpatient clinic before and after dis- Received: May 30, 2020 continuation of CTX prophylaxis.
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