IPCS PESTICIDE ACTIVITIES

The International Programme on Chemical Safety A major portion of this inventory includes sum- (IPCS) devotes significant resources to pesticides, pri- maries of toxicological evaluations of pesticides by marily for their assessment, but also for management JMPR. MRLs that have been recommended by the Joint support. The importance that IPCS places on these act- Meeting are not included. Nearly all of the MRLs have ivities is based on the widespread use of pesticides, been adopted or are under consideration by the Codex; both in agriculture and in public health, and a high level lists of Codex MRLs may be obtained from the Joint of public concern in both developed and developing FAO/WHO Food Standards Programme (see Annex 1 for countries because of the intrinsic toxicity of and potential address) or are available at the Codex web site, exposure to these chemicals. http://www.codexalimentarius.net/. This brief summary outlines the primary activities Annex 2 lists the reports and other documents of IPCS in the field of pesticides. The primary respons- prepared by JMPR. Many of the older publications that ibility for some of the activities summarized here are with are listed are out of print. The reports and evaluations programmes within WHO other than IPCS; however, that have been published by FAO may be obtained from IPCS plays a role in all of them, e.g. toxicity evaluations FAO Distribution and Sales Section, while those pub- in support of WHOPES and WHO guidelines for lished by WHO may be obtained from WHO Marketing drinking-water quality. and Dissemination (see Annex 1 for addresses). Toxicological evaluations are available on-line on IPCS I. Risk assessments INCHEM (http://www.inchem.org).

The ultimate goal of these activities is to identify B. Environmental Health Criteria (EHC) the type and extent of the potential risks to human health monographs and the environment arising from the manufacture, transportation, use, storage, or disposal of pesticides or EHC monographs are designed for scientific consumption of pesticide residues. The results of these experts responsible for the evaluation of the risk assessments are made available to governmental incurred by chemicals to human health and the environ- authorities and the general public through the ment, enabling relevant authorities to establish policies publication of reports and monographs. for the safe use of these chemicals. Over 50 mono- graphs dealing with pesticides have been published, A. Joint FAO/WHO Meeting on Pesticide Residues which are included in this inventory. EHC monographs (JMPR) may be obtained from WHO Marketing and Dissemination (see Annex 1 for address); they are also Joint Meetings have been held yearly since 1963, available on INCHEM (http://www.inchem.org). during which time approximately 230 pesticides have been evaluated. Members invited by WHO review tox- C. Health and Safety Guides (HSGs) icological and related data and estimate, when pos- sible, acceptable daily intakes (ADIs) of the pesticides HSGs are designed for a wide range of admin- for humans. Members invited by FAO review pesticide istrators, managers, and decision-makers in various use patterns (good agricultural practices), data on the governmental agencies and in industry and trade unions chemistry and composition of pesticides and methods who are involved in various aspects of the safe use of of analysis for pesticide residues, and estimate maxi- chemicals and the avoidance of environmental health mum residue levels (MRLs) that might occur as a result hazards. The documents summarize toxicity information of the use of the pesticides according to good agricu- in simple, non-technical language, and provide practical ltural practices. These MRLs serve as the basis for inter- advice on matters such as safe storage, handling and national standards established by the Codex Alimen- disposal of the chemical, accident prevention and health tarius Commission, which is administered by the Joint protection measures, first-aid and medical treatment in FAO/WHO Food Standards Programme, headquartered cases of over-exposure and clean-up procedures. at FAO Headquarters in Rome. JMPR advises the Codex Current regulations, guidelines, and standards are Committee on Pesticide Residues (CCPR), a special listed. More than 50 HSGs dealing with pesticides have subject committee of the Codex that is responsible for been published, which are included in this inventory. recommending Codex MRLs, which is hosted by the HSGs may be obtained from WHO Marketing and government of the Netherlands. Dissemination (see Annex 1 for address); they are also Principles used by JMPR for the toxicological available on INCHEM (http:// www.inchem.org). assessment of pesticide residues in food are summar- ized in Environmental Health Criteria (EHC) 104, which D. WHO/FAO Data Sheets on Pesticides was published in 1990. This publication is available from WHO Marketing and Dissemination (see Annex 1 In order to provide Member States, governments, for address). and various other institutions with basic toxicological and other relevant information on individual pesticides

Page 1 Introduction

WHO, in collaboration with FAO, issues WHO/FAO Data Diseases Contol, Prevention and Eradication (see Sheets on Pesticides. Priority is given to compounds in Annex 1 for more details on the publication and the wide use in public health programmes and/or in address). In addition, they are available electronically at agriculture, or having a high toxicity or an unusual toxicity www.who.int/ctd/whopes. profile. Since 1975, when the programme was initiated, 93 data sheets have been published in English and G. Joint FAO/WHO Meeting on Pesticide French. Data sheets are revised when appropriate. Specifications These documents are included in this inventory. WHO/FAO Pesticide Data Sheets may be obtained from In 2001 FAO and WHO agreed to develop jointly the Coordinator, International Programme on Chemical specifications for pesticides, thus providing unique, Safety (see Annex 1 for address). robust, and universally applicable standards for pest- icide quality. This joint programme is based on a E. WHO Guidelines for Drinking-Water Quality Memorandum of Understanding between the two Organizations and has led to the establishment of the The second edition of the Guidelines includes Joint FAO/WHO Meeting on Pesticide Specifications guideline values for 33 pesticides. These guideline (JMPS). The first Joint Meeting was held in Rome in values were developed by ad hoc working groups that June 2002. met over a period of several years in the late 1980s and The procedure for the establishment of WHO early 1990s. “Rolling revisions” of the Guidelines are specifications has, therefore, been revised and has planned. The first addendum, based upon the rolling been harmonized with the ‘new’ FAO procedure begun revisions, includes the revision of, or new guidelines for, in 1999, as described in the Manual on the Develop- 10 pesticides. This inventory identifies those pesticides ment and Use of FAO and WHO Specifications for on which guideline values have been established. The Pesticides. Under the new procedures the FAO and publications may be obtained from WHO Marketing and WHO specifications do not apply to nominally similar Dissemination (see Annex 1 for more details on the products of other manufacturers, nor to those in which publications and the address). The guidelines are also the active ingredient is produced by other routes by the accessible at http://www.who.int/ same manufacturer. The scope of these new speci- water_sanitation_health/GDWQ/index.html. fications may be extended to similar products when the two Organizations are satisfied that the additional F. The WHO Pesticides Evaluation Scheme products are equivalent to those which served as the (WHOPES) basis for the reference specification.

Traditionally, JMPR has not evaluated those pest- H. International Chemical Safety Cards (ICSCs) icides which do not leave residues in food, such as those used as household pesticides, and those which ICSCs summarize essential product identity data are primarily designed for public health use. These and health and safety information on chemicals for use pesticides go through the WHO Pesticides Evaluation by workers and employers in factories, agriculture and Scheme (WHOPES) which has existed since 1960. This other workplaces and for the public at large. The cards Scheme was revised in 1982 to take into account new are developed by making use of standard phrases com- trends in pesticide development and of vector and plemented, when appropriate, with information specific nuisance pest control. Under the Scheme, new pesti- to the chemical. They have been translated into many cides submitted by the agrochemical industry are evalu- languages. Approximately 1100 cards have been ated for their effectiveness against disease vectors and produced to date, a large number of which deal with nuisance pests and their toxicity to humans and individual pesticides. Cards on individual pesticides are beneficial species. The toxicity evaluations are now not included in this inventory. ICSCs and information on performed by Core Assessment Groups of the Joint their availability can be obtained from sales and Meeting on Pesticides (see section III of this introduc- subscription offices for official publications of the tion). The Evaluation Scheme consists of four phases: European Communities in various countries or from the laboratory evaluation, small-scale field evaluation on the Office for Official Publications of the European natural population of pests, large-scale field trials, and Communities, L-2985 Luxembourg. They are also establishment of specifications for pesticides. The available at http://www.who.int/pcs/pubs/pub_icsc.htm. results of WHOPES are eventually reviewed by approp- riate advisory and expert committees, many of the I. The WHO Recommended Classification of reports of which have been published in the WHO Pesticides by Hazard and Guidelines to Technical Report Series. WHOPES is coordinated by the Classification WHO Department of Communicable Diseases Control, Prevention and Eradication. This inventory identifies The classification was approved by the Twenty- those pesticides on which specifications have been Eighth World Health Assembly in 1975 and has since elaborated. The specifications may be obtained from the gained wide recognition in a number of Member States WHO Pesticide Evaluation Scheme, Communicable and by pesticide registration authorities. The Classifi-

Page 2 Introduction cation takes into account acute oral or dermal toxicity has been prepared. These modules are directed to and any irreversible effects that might be recognized. government officials with responsibility for pesticides, The Guidelines to Classification are revised periodically including registration and licensing, inspection, safe based on documented scientific evidence. The Class- use and disposal. Courses at this level have also been ification may be obtained from the Coordinator, Inter- conducted using existing training materials. national Programme on Chemical Safety (see Annex 1 IPCS has developed specific training activities on for address). The document also available on-line at the the safe use of pesticides. Courses are designed to IPCS web site, http://who.int/pcs. train the trainers at various levels (basic, intermediate, and high). A manual containing 120 modules in nine J. Concise International Chemical Assessment sections has been translated into many languages. Documents (CICADs) C. Epidemiology of acute pesticide poisonings Concise International Chemical Assessment Doc- uments (CICADs), which are based on existing national The unsafe use of pesticides represents a prob- assessment documents of high scientific quality, pro- lem to human health both in developed and developing vide, in a concise form, information similar to that in countries. Although the adverse effects of pesticides on EHC monographs and HSGs. Thirty-two CICADS have human and environmental health have been studied in been produced, and several more are in preparation. almost every country, controversy continues about the None of them cover pesticides, because it was decided extent and severity of the poisonings. The primary early on that CICADs are not appropriate for such data- reasons for the controversy centre on the limited scope rich chemicals. Because CICADs are prepared in of past reports and studies. parallel with national documents, they provide a tool for IPCS has initiated a project that will provide reli- sharing the burden of evaluations. able and updated information on the state of the prob- lem that will allow the comparability of epidemiological II. Provision of support for risk management data among various study populations. Data from differ- ent sources and study sites will be analyzed, guidance In addition to assessing risks, IPCS supports for strengthening national data collection systems will activities to reduce hazards from pesticides. This is be provided, and recommendations for preventive and accomplished through a number of activities, including educational activities will be given. These activities are those described here. These activities are implemented designed to reduce the incidence and severity of poi- through a variety of joint programmes with other inter- sonings/adverse effects. national organizations. Relevant activities on individual pesticides are not included in this inventory. Further III. Joint Meeting on Pesticides (JMP) information on these activities may be obtained from the Coordinator, International Programme on Chemical The Joint Meeting on Pesticides (JMP) was estab- Safety (see Annex 1 for address). lished to consolidate international activities on pesticide assessments. It was designed to consist of Core A. Prevention of pesticide poisonings Assessment Groups that perform the basic toxicological and environmental assessments of pesticides and This activity includes the production of guidelines three panels, the Panel on Residues in Food, the for poison control, the validation and availability of Environmental Panel, and the Panel on Public and antidotes used in the treatment of poisonings and, in Occupational Health, to provide practical advice on particular, the evaluation of the existing antidotes used pesticide safety and use. IPCS has overall responsibility in the treatment of pesticide poisonings. The key role in for coordinating this activity. these activities is the development of information To date, ten Core Assessment Group meetings systems for poison control, including harmonization and have been held. The first meeting was held in 1994 at exchange of data. Particular attention is given to the which time five draft EHC documents were reviewed. medical response to chemical emergencies in case of The results of these reviews are included in this sum- a chemical accident. mary, with further information provided in Annex 3. Core Assessment Groups met with the Panel on Residues in B. Education and training Food, which was organized by FAO, from 1995 through 2001, which constituted the normal Joint Meetings on IPCS provides training on basic chemical safety Pesticide Residues. The evaluations performed at these (toxicity, ecotoxicity, and risk assessment) for govern- Meetings are included under “JMPR evaluations” in this ment officials and public health advisers, primarily from summary. EHC documents were prepared on three developing countries; this training defines the principles pesticides at a Core Assessment Group meeting in of chemical safety and its application to pesticide safety early 1997. JMP has not been fully implemented for a and use as well as to other groups of chemicals. A number of reasons, and meetings of the other panels series of linked training modules at an advanced level have not been held.

Page 3 Inventory of IPCS and other WHO pesticide evaluations and summary of toxicological evaluations performed by the Joint Meeting on Pesticide Residues (JMPR)

ABAMECTIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 71751-41-2 OT IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.002 SUM OF ABAMECTIN AND 8,9-Z ISOMER 80,82 1995 0-0.001 TO BE APPLIED WHEN RESIDUES DO NOT CONTAIN delta-8,9 ISOMER 74 1994 0-0.0002 MIXTURE OF ABAMECTIN AND delta-8,9 ISOMER (SEE 1995 REPORT) 71,73 1992 0-0.0001 65,67

ACEPHATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 30560-19-1 OP IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.01 ACUTE RfD: 0.05 MG/KG BW 95,97 1990 0-0.03 59,61 1988 0-0.03 53,55 1987 0-0.003 50,52 1984 0-0.0005 TEMPORARY 42,43 1982 0-0.003 TEMPORARY 38,39 1976 0-0.02 26,27

N-ACETYL-GLUFOSINATE / NAG

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other OP JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.02 ADI APPLIES TO GLUFOSINATE-AMMONIUM, N-ACETYL-GLUFOSINATE, 86,88 AND 3-[HYDROXY(METHYL) PHOSPHINOYL] PROPIONIC ACID, ALONE OR IN COMBINATION (NAG IS A METABOLITE OF GLUFOSINATE-AMMONIUM)

ACROLEIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 107-02-8 OT AL HB 127 67 19 36 63 CICAD: 43

[see Annex 1 for explanation of abbreviations] Page 2 IPCS and other WHO pesticide evaluations

ACRYLONITRILE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 107-13-1 OT FM 28 19 71 CICAD: 39 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 3,5

ALACHLOR

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 15972-60-8 OC HB 86 *

ALDICARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 116-06-3 CB IN AC NE 121 64 53 53 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.003 (1992) ACUTE RfD: 0.003 MG/KG BW 74 1992 0-0.003 65,67 1982 0-0.005 38,39 1979 0-0.001 32,33

ALDRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 309-00-2 OC CO 91 21 41 5 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0.0001 (PTDI) COMBINED TOTAL ALDRIN + DIELDRIN; SEE ALSO DIELDRIN 71 1977 0-0.0001 COMBINED TOTAL ALDRIN + DIELDRIN; SEE ALSO DIELDRIN 28,29 1966 0-0.0001 SUM OF ALDRIN & DIELDRIN; SEE ALSO DIELDRIN 6,7 1965 NO ADI SEE ALSO DIELDRIN 3,4 1963 NO ADI SEE ALSO DIELDRIN 2

ALLETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 584-79-2 PY IN 87 24 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 3,4

ALUMINIUM PHOSPHIDE SEE HYDROGEN PHOSPHIDE

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 3

AMINOCARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2032-59-9 CB IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1979 NO ADI 32,33

AMINOMETHYLPHOSPHONIC ACID SEE AMPA

AMITRAZ

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 33089-61-1 OT IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.01 ACUTE RfD: 0.01 MG/KG BW 83,85 1990 0-0.003 59 1984 0-0.003 42,43 1980 0-0.0005 TEMPORARY 34,35

AMITROLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 61-82-5 HC HB 158 85 79 7 41 79 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.002 80,82 1993 0-0.0005 TEMPORARY 68,70 1977 0-0.00003 CONDITIONAL 28,29 1974 0-0.00003 CONDITIONAL 22,23

AMPA

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other OP JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.3 SUM OF GLYPHOSATE AND AMPA (AMPA IS A METABOLITE OF 80,82 GLYPHOSATE)

[see Annex 1 for explanation of abbreviations] Page 4 IPCS and other WHO pesticide evaluations

ANILAZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 101-05-3 OC HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 0-0.1 56,58

ARSENATE, CALCIUM & LEAD

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7778-44-1; 7645-25-2 AS IN HB RO 18* 224* 1* 2* 23* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1968 NO ADI 10,11 1965 NO ADI 3,4 1963 NO ADI 2

ATRAZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1912-24-9 HC OC HB 47 82 53 73 *

AZINPHOS-ETHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2642-71-9 OP HC IN AC 72 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1973 NO ADI 20,21

AZINPHOS-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 86-50-0 OP HC IN AC 59 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1991 0-0.005 62,64 1973 0-0.0025 20,21 1968 0-0.0025 10,11 1965 0-0.0025 4 1963 0-0.0025 2

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 5

AZOCYCLOTIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 41083-11-8 SN HC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.007 GROUP ADI WITH CYHEXATIN 71 1991 0-0.001 62 1989 0-0.003 56,58 1981 0-0.003 36,37

BENALAXYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 71626-11-4 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1987 0-0.05 50,52

BENDIOCARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 22781-23-3 CB HC IN 52 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1984 0-0.004 42,43 1982 0-0.002 TEMPORARY 38,39

BENOMYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 17804-35-2 CB HC FU 148 81 87 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.1 RESIDUES SHOULD BE COMPARED AGAINST THE ADI FOR 74,76 CARBENDAZIM; ENVIRONMENTAL ASSESSMENT ALSO PERFORMED 1983 0-0.02 40,41 1975 NO ADI 24,25

BENTAZONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 25057-89-0 HC HB 48 * ** JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.1 (1998) ACUTE RfD UNNECESSARY 86 1998 0-0.1 83,85 1991 0-0.1 62,64

[see Annex 1 for explanation of abbreviations] Page 6 IPCS and other WHO pesticide evaluations

BENZENE HEXACHLORIDE SEE LINDANE OR BHC / HCH

BHC / HCH

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 608-73-1 OC IN 123* 5* 20* 42* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1973 NO ADI TECHNICAL GRADES; MIXTURES OF ISOMERS 20,21 1968 NO ADI TECHNICAL GRADES; MIXTURES OF ISOMERS 10,11

BIFENTHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 82657-04-3 PY IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.02 65,67

BINAPACRYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 485-31-4 DN FU AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1985 NO ADI 44,46 1982 ADI WITHDRAWN 38 1969 0-0.0025 12,13

BIORESMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 28434-01-7 PY IN 92 25 34 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1991 0-0.03 62,64 1976 NO ADI 26,27

BIS(TRIBUTYLTIN)OXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 56-35-9 SN FU MO AL BA 65

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 7

BITERTANOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 55179-31-2 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.01 ACUTE RfD UNNECESSARY 83,85 1988 0-0.01 53 1987 0-0.003 50,52 1983 0-0.005 TEMPORARY 40,41

BRODIFACOUM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 56073-10-0 OT RO 175 93 57 *

BROMADIOLONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 28772-56-7 OT RO 94 88

BROMIDE ION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other BR FM JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1988 0-1.0 SEE ALSO BROMOMETHANE & DIBROMOETHANE 53,55 1971 0-1.0 ADI ESTABLISHED IN 1966; SEE ALSO BROMOMETHANE 16,17 & DIBROMOETHANE

BROMOMETHANE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 74-83-9 BR FM IN TE NE RO 166* 86* 5* 41* 45* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1966 1.0 AS BROMIDE ION SEE ALSO BROMIDE ION 6,7 1965 NO ADI SEE ALSO BROMIDE ION 3,5

[see Annex 1 for explanation of abbreviations] Page 8 IPCS and other WHO pesticide evaluations

BROMOPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2104-96-3 OP IN 76 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1977 0-0.04 28,29 1972 0-0.006 TEMPORARY 18,19

BROMOPHOS-ETHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 4824-78-6 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1975 0-0.003 24,25 1972 0-0.003 TEMPORARY 18,19

BROMOPROPYLATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 18181-80-1 OT AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 68,70 1973 0-0.008 20,21

BUPROFEZIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 69327-76-0 HC IG IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.01 (1991) ACUTE RfD UNNECESSARY 86 1991 0-0.01 62,64

BUTOCARBOXIM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 34681-10-2 CB IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1985 NO ADI 44 1984 NO ADI 42

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 9

SEC-BUTYLAMINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13952-84-6 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1984 TEMP ADI WITHDRAWN 42 1981 0-0.1 TEMPORARY 36,37 1978 0-0.1 TEMPORARY 30,31 1975 0-0.2 TEMPORARY 24,25

CADUSAFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 95465-99-9 OP IN NE JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1991 0-0.0003 62,64

CALCIUM ARSENATE SEE ARSENATE, CALCIUM & LEAD

CAMPHECHLOR

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 8001-35-2 OC IN RO AC 45 40 20 20* 79* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1973 NO ADI 20,21 1968 NO ADI 10,11

CAPTAFOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2425-06-1 OC HC FU 49 53 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1985 TEMP ADI WITHDRAWN 44 1982 0-0.01 TEMPORARY 38 1977 0-0.1 28,29 1973 0-0.05 TEMPORARY 20,21 1969 0-0.05 TEMPORARY 12,13

[see Annex 1 for explanation of abbreviations] Page 10 IPCS and other WHO pesticide evaluations

CAPTAN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 133-06-2 OC HC FU 50 9 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.1 (1995) ACUTE RfD UNNECESSARY 89 1995 0-0.1 74,76 1990 0-0.1 59,61 1984 0-0.1 42,43 1982 0-0.01 TEMPORARY 38,39 1978 0-0.1 30,31 1977 0-0.1 28,29 1973 0-0.1 20,21 1969 0-0.125 TEMPORARY 12,13 1965 0-0.1 3,4 1963 0-0.1 2

CARBARYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 63-25-2 CB IN PG 153 78 3 12 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.008 ACUTE RfD: 0.2 MG/KG BW 92,94 2000 0-0.003 89 1996 0-0.003 77,79 1973 0-0.01 20,21 1969 0-0.01 TEMPORARY 12,13 1967 0-0.02 8,9 1966 0-0.02 6,7 1965 0-0.02 3,4 1963 0-0.02 2

CARBENDAZIM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 10605-21-7 CB HC FU 149 82 89 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.03 ENVIRONMENTAL ASSESSMENT ALSO PERFORMED 74,76 1985 0-0.01 44,46 1983 0-0.01 40,41 1977 NO ADI 28,29 1973 NO ADI 20,21

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 11

CARBOFURAN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1563-66-2 CB HC IN AC NE 56 * ** JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.002 (1996) ACUTE RfD: 0.009 MG/KG BW 95,97 1996 0-0.002 77,79 1982 0-0.01 38 1980 0-0.01 34,35 1979 0-0.003 TEMPORARY 32,33 1976 0-0.003 TEMPORARY 26,27

CARBON DISULFIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 75-15-0 OT FM IN 10 CICAD: 46 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 3,5

CARBON TETRACHLORIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 56-23-5 OC FM 208 108 1 20 71 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 3,5

CARBOPHENOTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 786-19-6 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1980 0-0.0005 34,35 1979 0-0.0005 32,33 1977 0-0.0002 TEMPORARY 28,29 1976 TEMP ADI WITHDRAWN 26,27 1972 0-0.005 TEMPORARY 18,19

[see Annex 1 for explanation of abbreviations] Page 12 IPCS and other WHO pesticide evaluations

CARBOSULFAN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 55285-14-8 CB HC IN NE JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.01 47,49 1984 0-0.005 TEMPORARY 42,43

CARTAP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 15263-53-3 TC IN 76 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 ADI WITHDRAWN 74 1978 0-0.1 30,31 1976 0-0.05 TEMPORARY 26,27

CHINOMETHIONAT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2439-01-2 HC AC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1987 0-0.006 50,52 1984 TEMP ADI WITHDRAWN 42 1981 0-0.003 TEMPORARY 36,37 1977 0-0.003 TEMPORARY 28,29 1974 0-0.003 TEMPORARY 22,23 1968 NO ADI 10,11

CHLORBENSIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 103-17-3 OC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 0-0.01 4 1963 0-0.01 2

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 13

CHLORDANE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 57-74-9 OC CO 34 13 36 20 42 53 79 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0.0005 (PTDI) 71 1986 0-0.0005 47,49 1984 0-0.001 TEMPORARY 42 1982 0-0.001 TEMPORARY 38,39 1978 0-0.001 30 1977 0-0.001 28,29 1970 0-0.001 14,15 1967 0-0.001 8,9 1965 NO ADI 3,4 1963 NO ADI 2

CHLORDECONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 143-50-0 OC IN 43 41 20

CHLORDIMEFORM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 6164-98-3 OT IN AC 199 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1987 TEMP ADI WITHDRAWN 50,52 1985 0-0.0001 TEMPORARY 44,46 1980 0-0.0001 TEMPORARY 34,35 1979 0-0.0001 TEMPORARY 32,33 1978 0-0.001 TEMPORARY 30,31 1977 0-0.01 TEMPORARY 28 1975 0-0.01 TEMPORARY 24,25 1971 0-0.01 TEMPORARY 16,17

CHLORFENSON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 80-33-1 OC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 0-0.01 4 1963 0-0.01 2

[see Annex 1 for explanation of abbreviations] Page 14 IPCS and other WHO pesticide evaluations

CHLORFENVINPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 470-90-6 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.0005 71,73 1971 0-0.002 16,17

CHLORMEQUAT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7003-89-6 OT PG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.05 (1997) ACUTE RfD: 0.05 MG/KG BW 86,88 1997 0-0.05 80,82 1994 NO ADI 71,73 1972 0-0.05 18,19 1970 NO ADI 14,15

CHLOROBENZILATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 510-15-6 OC AC 5 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1980 0-0.02 34,35 1968 0-0.02 10,11 1965 NO ADI 4 1963 NO ADI 2

CHLOROCHOLINE CHLORIDE SEE CHLORMEQUAT

CHLOROPHACINONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 3691-35-8 OT RO 175 62

CHLOROPICRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 76-06-2 OC FM FU NE IN RO JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 3,5

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 15

CHLOROPROPYLATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 5836-10-2 OC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1972 TEMP ADI WITHDRAWN 18 1968 0-0.01 TEMPORARY 10,11

CHLOROTHALONIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1897-45-6 OC FU 183 98 30 73 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.03 SEE ANNEX 3 1992 0-0.03 65,67 1990 0-0.03 59,61 1987 0-0.003 TEMPORARY 50,52 1985 0-0.0005 TEMPORARY 44,46 1983 0-0.005 TEMPORARY 40,41 1981 0-0.005 TEMPORARY 36,37 1979 0-0.03 TEMPORARY 32,33 1977 0-0.03 TEMPORARY 28,29 1974 0-0.03 TEMPORARY 22,23

CHLOROTOLURON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 15545-48-9 UR OC HB *

CHLORPHOXIM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 14816-20-7 OP IN 32

CHLORPROPHAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 101-21-3 CB HB PG 12 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.03 ACUTE RfD: 0.03 MG/KG BW 89,91 1965 NO ADI 3,4 1963 NO ADI 2

[see Annex 1 for explanation of abbreviations] Page 16 IPCS and other WHO pesticide evaluations

CHLORPYRIFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2921-88-2 OP HC IN 18 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.01 ACUTE RfD: 0.1 MG/KG BW 86,88 1982 0-0.01 38,39 1977 0-0.001 28,29 1972 0-0.0015 18,19

CHLORPYRIFOS-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 5598-13-0 OP HC IN AC 33 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.01 (1992) ACUTE RfD UNNECESSARY 92 1992 0-0.01 65,67 1991 0-0.001 62,64 1975 0-0.01 24,25

CHLORTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 500-28-7 OP IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 4 1963 NO ADI 2

CLETHODIM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 110429-62-4 OT HB JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.01 (1994) ACUTE RfD UNNECESSARY 86 1994 0-0.01 71,73

CLOFENTEZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 74115-24-5 HC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.02 47,49

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 17

COUMAPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 56-72-4 OP HC AC IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1990 NO ADI 59,61 1987 NO ADI 50 1980 TEMP ADI WITHDRAWN 34,35 1978 0-0.0005 TEMPORARY 30 1975 0-0.0005 TEMPORARY 24 1972 0-0.0005 TEMPORARY 18,19 1968 0-0.0005 TEMPORARY 10,11

CRUFOMATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 299-86-5 OP IN AN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1968 0-0.1 10,11

CYANAZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 21725-46-2 HC HB **

CYANOFENPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2636-26-2 OP IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1983 TEMP ADI WITHDRAWN 40 1980 0-0.001 TEMPORARY 34,35 1975 0-0.005 TEMPORARY 24,25

CYCLOXYDIM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 99434-58-9 HC HB JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.07 65,67

[see Annex 1 for explanation of abbreviations] Page 18 IPCS and other WHO pesticide evaluations

CYFLUTHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 68359-37-5 PY IN * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.02 JECFA EVALUATION SEE ANNEX 3 1987 0-0.02 50,52

CYHALOTHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 68085-85-8 PY IN 99 38 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.002 TEMPORARY JECFA EVALUATION SEE ANNEX 3 2000 0-0.002 TEMPORARY JECFA EVALUATION SEE ANNEX 3 1984 0-0.02 42,43

CYHEXATIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13121-70-5 SN AC 15* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.007 GROUP ADI WITH AZOCYCLOTIN 71,73 1991 0-0.001 62,64 1989 0-0.008 56,58 1988 0-0.008 53 1981 0-0.008 36,37 1980 0-0.008 TEMPORARY 34,35 1978 0-0.008 TEMPORARY 30,31 1977 0-0.007 TEMPORARY 28 1973 0-0.007 TEMPORARY EVALUATED UNDER TRICYCLOHEXYLTIN HYDROXIDE 20,21 1970 0-0.0075 TEMPORARY EVALUATED UNDER TRICYCLOHEXYLTIN HYDROXIDE 14,15

CYPERMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 52315-07-8 PY IN 82 22 58 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.05 JECFA EVALUATION SEE ANNEX 3 1981 0-0.05 36,37 1979 0-0.006 TEMPORARY 32,33

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 19

ALPHA-CYPERMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 67375-30-8 PY IN 142 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.02 JECFA EVALUATION SEE ANNEX 3

CYROMAZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 66215-27-8 HC IG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1990 0-0.02 59,61

2,4-D

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 94-75-7 PO HB 29 84 5 37 15 41 * ** JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0-01 (1996) ACUTE RfD UNNECESSARY 92 1997 0-0.01 (1996) ENVIRONMENTAL ASSESSMENT 80,82 1996 0-0.01 SUM OF 2,4-D AND ITS SALTS AND ESTERS EXPRESSED AS 2,4-D 77,79 1975 0-0.3 24,25 1974 0-0.3 22,23 1971 0-0.3 16,17 1970 NO ADI 14,15

DAMINOZIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1596-84-5 AM PG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1991 0-0.5 DAMINOZIDE CONTAINING LESS THAN 30 MG UDMH / KG 62,64 1989 0-0.5 DAMINOZIDE CONTAINING LESS THAN 30 MG 56,58 1,1-DIMETHYLHYDRAZINE (UDMH) / KG 1983 NO ADI 40,41 1977 NO ADI 28,29

2,4-DB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 94-82-6 PO HB *

[see Annex 1 for explanation of abbreviations] Page 20 IPCS and other WHO pesticide evaluations

DBCP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 96-12-9 OC NE *

DDT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 50-29-3 OC CO 9 83 21 5 42 53 * * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0.01 (PTDI) ACUTE RfD UNNECESSARY (CONFIRMED BY 2002 JMPR) 89,91,95 1994 0.02 (PTDI) 71 1984 0-0.02 42,43 1983 0-0.005 CONDITIONAL 40 1979 0-0.005 CONDITIONAL 32,33 1977 0-0.005 CONDITIONAL 28 1974 0-0.005 CONDITIONAL 22 1971 0-0.005 CONDITIONAL 16 1969 0-0.005 CONDITIONAL 12,13 1967 0-0.01 ANY COMBINATION OF DDT, DDD & DDE 8,9 1966 0-0.01 6,7 1965 0-0.01 3,4 1963 0-0.005 2

DECAMETHRIN SEE DELTAMETHRIN

DEET

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 134-62-3 OT RE 80 *

DELTAMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 52918-63-5 PY IN 97 30 50 53 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.01 ACUTE RfD: 0.05 MG/KG BW 89,91 1982 0-0.01 38,39 1981 NO ADI 36,37 1980 NO ADI 34,35

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 21

DEMETON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 8065-48-3 OP IN AC 60 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1984 NO ADI 42,43 1982 ADI WITHDRAWN 38 1965 0-0.0025 4 1963 0-0.0025 2

DEMETON-S-METHYL & RELATED COMPOUNDS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 919-86-8 OP IN AC 197 61 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 0-0.0003 GROUP ADI, ALONE OR IN COMBINATION 56,58 1984 NO ADI EVALUATED UNDER OXYDEMETON-METHYL / DEMETON-S-METHYL 42,43 SULFOXIDE 1982 ADI WITHDRAWN 38 1973 0-0.005 TOTAL DEMETON-S-METHYL & RELATED COMPOUNDS SHOULD 20,21 NOT EXCEED THIS FIGURE

DEMETON-S-METHYL SULFONE SEE DEMETON-S-METHYL & RELATED COMPOUNDS

DEMETON-S-METHYL SULFOXIDE SEE OXYDEMETON-METHYL

DIALIFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 10311-84-9 OP HC IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1982 ADI WITHDRAWN 38 1976 0-0.003 26,27

[see Annex 1 for explanation of abbreviations] Page 22 IPCS and other WHO pesticide evaluations

DIAZINON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 333-41-5 OP HC IN AC 198 45 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.002 (1993) ACUTE RfD: 0.03 MG/KG BW 92,94 1993 0-0.002 68,70 1970 0-0.002 14,15 1966 0-0.002 6,7 1965 0-0.0002 3,4 1963 NO ADI 2

1,2-DIBROMOETHANE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 106-93-4 BR FM IN NE 177 15* 71* * ** JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 NO ADI SEE ANNEX 3 1966 0-1.0 AS BROMIDE ION SEE ALSO BROMIDE ION 6,7 1965 NO ADI SEE ALSO BROMIDE ION 3,5

DICHLOFLUANID

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1085-98-9 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1983 0-0.3 40,41 1979 0-0.3 TEMPORARY 32,33 1977 0-0.3 TEMPORARY 28,29 1974 0-0.3 TEMPORARY 22,23 1969 NO ADI 12,13

1,2-DICHLOROETHANE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 107-06-2 OC FM IN NE 62 176 55 20 71 * CICAD 1 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 NO ADI SEE ANNEX 3 1965 NO ADI 3,5

1,2-DICHLOROPROPANE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 78-87-5 OC FU 146 76 41 * **

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 23

1,3-DICHLOROPROPENE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 542-75-6 OC NE 146 76 41 *

DICHLORPROP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 120-36-5 PO HB *

DICHLORVOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 62-73-7 OP IN AN 79 18 2 20 53 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.004 68,70 1977 0-0.004 28,29 1970 0-0.004 14,15 1967 0-0.004 8,9 1966 0-0.004 6,7 1965 NO ADI 3,4

DICLORAN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 99-30-9 OC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.01 ACUTE RfD UNNECESSARY 83,85 1977 0-0.03 28,29 1974 0-0.03 TEMPORARY 22,23

DICOFOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 115-32-2 OC AC 81 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.002 65,67 1968 0-0.025 10,11

[see Annex 1 for explanation of abbreviations] Page 24 IPCS and other WHO pesticide evaluations

DICYCLANIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 112636-83-6 HC IN IG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.007 JECFA EVALUATION SEE ANNEX 3

DIELDRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 60-57-1 OC CO 91 21 17 5 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0.0001 (PTDI) COMBINED TOTAL ALDRIN + DIELDRIN; SEE ALSO ALDRIN 71 1977 0-0.0001 COMBINED TOTAL ALDRIN + DIELDRIN; SEE ALSO ALDRIN 28,29 1970 0-0.0001 SUM OF ALDRIN & DIELDRIN BY WEIGHT; SEE ALSO ALDRIN 14,15 1967 0-0.0001 SUM OF ALDRIN & DIELDRIN; SEE ALSO ALDRIN 8,9 1966 0-0.0001 SUM OF ALDRIN & DIELDRIN; SEE ALSO ALDRIN 6,7 1965 NO ADI SEE ALSO ALDRIN 3,4 1963 NO ADI SEE ALSO ALDRIN 2

DIFENACOUM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 56073-07-5 OT RO 175 95

DIFLUBENZURON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 35367-38-5 UR IG 184 99 77 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.02 ACUTE RfD UNNECESSARY 92,94 1994 0-0.02 SEE ANNEX 3 1985 0-0.02 44,46 1984 0-0.004 TEMPORARY 42 1981 0-0.004 TEMPORARY 36,37

DIMETHIPIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 55290-64-7 HC HB PG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.02 ACUTE RfD: 0.02 MG/KG BW 86,88 1988 0-0.02 53,55 1987 0-0.003 TEMPORARY 50 1985 0-0.003 TEMPORARY 44,46

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 25

DIMETHOATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 60-51-5 OP IN AC 90 20 42 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.002 SUM OF DIMETHOATE AND OMETHOATE EXPRESSED AS DIMETHOATE 77,79 1987 0-0.01 50,52 1984 0-0.002 TEMPORARY 42,43 1967 0-0.02 8,9 1965 0-0.004 3,4 1963 0-0.004 2

DIMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 70-38-2 PY IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 3,4

DINOCAP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 39300-45-3 DN AC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.008 (1998) ACUTE RfD: 0.03 MG/KG BW (FOR THE GENERAL POPULATION) 89 1998 0-0.008 ACUTE RfD: 0.008 MG/KG BW (FOR WOMEN OF CHILD-BEARING AGE); 86, 85; PUBLISHED IN 1999 REPORT 1989 0-0.001 56,58 1974 NO ADI 22,23 1969 NO ADI 12,13

DIOXATHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 78-34-2 OP HC IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1968 0-0.0015 10,11

[see Annex 1 for explanation of abbreviations] Page 26 IPCS and other WHO pesticide evaluations

DIPHENYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 92-52-4 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1967 0-0.125 8,9 1966 0-0.125 6,7

DIPHENYLAMINE / DPA

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 122-39-4 OT OT JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.08 ACUTE RfD UNNECESSARY 83,85 1984 0-0.02 FOR 99.9% PURE MATERIAL 42,43 1982 0-0.02 TEMPORARY 38,39 1976 0-0.02 26,27 1969 0-0.025 12,13

DIQUAT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2764-72-9 HC HB 39 52 40 ** JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.002 AS DIQUAT ION 68,70 1977 0-0.008 AS DIQUAT ION 28,29 1972 0-0.0036 AS DIQUAT ION 18,19 1970 0-0.002 TEMPORARY AS DIQUAT ION 14,15

DISULFOTON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 298-04-4 OP IN AC 68 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.0003 (1991) ACUTE RfD: 0.003 MG/KG BW 77 1991 0-0.0003 62,64 1975 0-0.002 24,25 1973 0-0.001 TEMPORARY 20,21

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 27

DITHIANON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 3347-22-6 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.01 65,67

DNOC

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 534-52-1 DN IN FU AC HB 220* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 NO ADI 4 1963 NO ADI 2

DODINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2439-10-3 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.1 ACUTE RfD: 0.2 MG/KG BW (CONFIRMED BY 2002 JMPR) 89,91,95 1976 0-0.01 26,27 1974 0-0.01 TEMPORARY 22,23

DPA SEE DIPHENYLAMINE

EDIFENPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 17109-49-8 OP FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1981 0-0.003 36,37 1979 0-0.003 TEMPORARY 32,33 1976 0-0.003 TEMPORARY 26,27

[see Annex 1 for explanation of abbreviations] Page 28 IPCS and other WHO pesticide evaluations

ENDOSULFAN (ENDOSULFAN A, ENDOSULFAN B, ENDOSULFAN SULFATE)

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 115-29-7; 1031-07-8 OC HC IN AC 40 17 15 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.006 ACUTE RfD: 0.02 MG/KG BW 83,85 1989 0-0.006 56,58 1985 0-0.008 TEMPORARY 44 1982 0-0.008 TEMPORARY 38,39 1968 0-0.0075 10,11 1967 NO ADI 8,9 1965 NO ADI 4 1963 NO ADI 2

ENDRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 72-20-8 OC CO 130 60 1 5 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0.0002 (PTDI) 71 1970 0-0.0002 14,15 1965 NO ADI 3,4 1963 NO ADI 2

ESFENVALERATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 66230-04-4 PY IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.02 ACUTE RfD: 0.02 MG/KG BW 95,97

ETHEPHON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 16672-87-0 OP PG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0-05 (1997) ACUTE RfD: 0.05 MG/KG BW 95,97 1997 0-0.05 80 1995 0-0.05 74 1993 0-0.05 68,70 1978 NO ADI 30,31 1977 NO ADI 28

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 29

ETHIOFENCARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 29973-13-5 CB IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1982 0-0.1 38,39 1977 0-0.1 TEMPORARY 28,29

ETHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 563-12-2 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1990 0-0.002 59,61 1989 0-0.006 TEMPORARY 56 1986 0-0.006 TEMPORARY 47,49 1985 0-0.0005 TEMPORARY 44 1982 0-0.001 TEMPORARY 38,39 1972 0-0.005 18,19 1968 0-0.00125 10,11

ETHOPROPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13194-48-4 OP IN NE 70 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.0004 ACUTE RfD: 0.05 MG/KG BW 86,88 1987 0-0.0003 50,52 1983 NO ADI 40,41

ETHOXYQUIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 91-53-2 HC PG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.005 ACUTE RfD UNNECESSARY 83,85 1969 0-0.06 12,13

ETHYLENE DIBROMIDE SEE 1,2-DIBROMOETHANE

ETHYLENE DICHLORIDE SEE 1,2-DICHLOROETHANE

[see Annex 1 for explanation of abbreviations] Page 30 IPCS and other WHO pesticide evaluations

ETHYLENE OXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 75-21-8 OT FM IN 55 11 36 42 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1968 NO ADI 10,11 1965 NO ADI 3,5

ETHYLENETHIOUREA / ETU

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 96-45-7 UR 78 7 79 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.004 68,70 1988 0-0.002 TEMPORARY 53,55 1986 0-0.002 TEMPORARY 47 1980 0-0.002 TEMPORARY LISTED UNDER DITHIOCARBAMATES 34,35

ETOFENPROX

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 80844-07-1 PO IN * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 68,70

ETRIMFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 38260-54-7 OP HC IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.003 47 1982 0-0.003 38,39 1980 0-0.003 TEMPORARY 34,35

ETU SEE ETHYLENETHIOUREA

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 31

FENAMIPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 22224-92-6 OP NE IN 92 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0-0008 (1997) ACUTE RfD: 0.003 MG/KG BW 95,97 1997 0-0.0008 ACUTE RfD: 0.0008 MG/KG BW 80,82 1987 0-0.0005 50,52 1985 0-0.0003 TEMPORARY 44,46 1974 0-0.0006 22,23

FENARIMOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 60168-88-9 OC HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.01 ENVIRONMENTAL ASSESSMENT ALSO PERFORMED 74,76

FENBUCONAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 114369-43-6 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.03 80,82

FENBUTATIN OXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13356-08-6 SN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.03 65,67 1977 0-0.03 28,29

FENCHLORPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 299-84-3 OP IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1968 0-0.01 10,11

[see Annex 1 for explanation of abbreviations] Page 32 IPCS and other WHO pesticide evaluations

FENITROTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 122-14-5 OP IN 133 65 30 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.005 ACUTE RfD: 0.04 MG/KG BW 89,91 1988 0-0.005 53,55 1986 0-0.003 47,49 1984 0-0.003 TEMPORARY 42,43 1982 0-0.001 TEMPORARY 38,39 1977 0-0.005 28,29 1974 0-0.005 22,23 1969 0-0.001 TEMPORARY 12,13

FENOPROP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 93-72-1 PO HB *

FENPROPATHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 64257-84-7 PY AC IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 68,70

FENPROPIMORPH

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 67306-03-0; 67564-91-4 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.003 (1994) ACUTE RfD: 1 MG/KG BW 92,94 1994 0-0.003 71,73

FENPYROXIMATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 134098-61-6 HC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.01 74,76

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 33

FENSULFOTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 115-90-2 OP IN NE 44 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1982 0-0.0003 38,39 1972 0-0.0003 18,19

FENTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 55-38-9 OP IN 23 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.007 (1995) ACUTE RFD: 0.01 MG/KG BW 80,82 1995 0-0.007 ACUTE RfD: 0.007 MG/KG BW; ENVIRONMENTAL ASSESSMENT 74,76 ALSO PERFORMED 1980 0-0.001 34,35 1979 0-0.0005 TEMPORARY 32,33 1978 0-0.0005 TEMPORARY 30,31 1975 0-0.0005 TEMPORARY 24,25 1971 0-0.0005 TEMPORARY 16,17

FENTIN ACETATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 900-95-8 SN FU AL MO 15* 22 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1970 0-0.0005 ALONE OR IN COMBINATION WITH OTHER FENTIN COMPOUNDS 14,15 1965 NO ADI EVALUATED UNDER TRIPHENYLTIN 3,4 1963 NO ADI EVALUATED UNDER TRIPHENYLTIN 2

FENTIN CHLORIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 639-58-7 SN FU AL 15* 22 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1970 0-0.0005 ALONE OR IN COMBINATION WITH OTHER FENTIN COMPOUNDS 14,15 1965 NO ADI EVALUATED UNDER TRIPHENYLTIN 3,4 1963 NO ADI EVALUATED UNDER TRIPHENYLTIN 2

[see Annex 1 for explanation of abbreviations] Page 34 IPCS and other WHO pesticide evaluations

FENTIN COMPOUNDS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other SN FU AL MO 15* 22 CICAD 13 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1991 0-0.0005 62,64 1970 0-0.0005 APPLICABLE TO FENTIN ACETATE, FENTIN CHLORIDE & FENTIN 14,15 HYDROXYDE & TO THE SUM OF EACH 1965 NO ADI EVALUATED UNDER TRIPHENYLTIN 3,4 1963 NO ADI EVALUATED UNDER TRIPHENYLTIN 2

FENTIN HYDROXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 76-87-9 SN FU 15* 22 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1970 0-0.0005 ALONE OR IN COMBINATION WITH OTHER FENTIN COMPOUNDS 14,15 1965 NO ADI EVALUATED UNDER TRIPHENYLTIN 3,4 1963 NO ADI EVALUATED UNDER TRIPHENYLTIN 2

FENVALERATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 51630-58-1 PY IN AC 95 34 90 53 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.02 47 1984 0-0.02 TEMPORARY 42,43 1982 0-0.007 TEMPORARY 38 1981 0-0.007 TEMPORARY 36,37 1979 0-0.06 TEMPORARY 32,33

FERBAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 14484-64-1 TC FU 78 94 12 42 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.003 GROUP ADI FOR FERBAM AND ZIRAM 77,79 1980 0-0.02 LISTED UNDER DITHIOCARBAMATES; SUM OF FERBAM & ZIRAM 34,35 1977 0-0.02 LISTED UNDER DITHIOCARBAMATES; SUM OF FERBAM & ZIRAM 28,29 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF ALL DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY LISTED UNDER DITHIOCARBAMATES; APPLICABLE TO THE PARENT 14,15 COMPOUNDS ONLY & TO THE SUM OF ALL THE DITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY ALONE OR IN COMBINATION WITH OTHER 8,9 DIMETHYLDITHIOCARBAMATES (THIRAM & ZIRAM) 1965 NO ADI 4 1963 NO ADI 2

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 35

FIPRONIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 120068-37-3 HC IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.0002 GROUP ADI FOR FIPRONIL AND FIPRONIL-DESULFINYL; 89,91 ACUTE RfD: 0.003 MG/KG BW (FOR FIPRONIL & FIPRONYL-DESULFINYL, ALONE OR IN COMBINATION) 1997 0-0.0002 A TEMPORARY ADI OF 0-0.00003 MG/KG BW WAS ALLOCATED TO A 80,82 PHOTODEGRADATION PRODUCT, FIPRONIL-DESULFINYL; ACUTE RFD FOR PARENT AND FIPROINIL-DESULFINYL: 0.003 MG/KG BW

FLUAZURON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 86811-58-7 UR IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.04 JECFA EVALUATION SEE ANNEX 3

FLUCYTHRINATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 70124-77-5 PY IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1985 0-0.02 44,46

FLUMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 69770-45-2 PY IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.004 77,79

FLUSILAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 85509-19-9 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.001 74,76 1989 0-0.001 56,58

[see Annex 1 for explanation of abbreviations] Page 36 IPCS and other WHO pesticide evaluations

FLUTOLANIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 66332-96-5 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.09 ACUTE RfD: UNNECESSARY 95,97

FOLPET

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 133-07-3 OC HC FU 72 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.1 74,76 1993 0-0.01 TEMPORARY 68 1990 0-0.01 TEMPORARY 59,61 1986 0-0.01 TEMPORARY 47,49 1984 TEMP ADI WITHDRAWN 42,43 1982 0-0.1 TEMPORARY 38 1973 0-0.1 20,21 1969 0-0.16 TEMPORARY 12,13

FORMOTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2540-82-1 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 ADI WITHDRAWN 77 1973 0-0.02 20,21 1969 NO ADI 12,13

GAMMA-BHC / GAMMA-HCH / GAMMA-HEXACHLOROCYCLOHEXANE SEE LINDANE

GLUFOSINATE-AMMONIUM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 77182-82-2 OP HB JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.02 ADI APPLIES TO GLUFOSINATE-AMMONIUM, N-ACETYL-GLUFOSINATE, 86,88 AND 3-[HYDROXY(METHYL) PHOSPHINOYL]PROPIONIC ACID, ALONE OR IN COMBINATION; ACUTE RfD UNNECESSARY 1991 0-0.02 62,64

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 37

GLYPHOSATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1071-83-6 OP HB 159 91 ** JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.3 SUM OF GLYPHOSATE AND AMPA, A METABOLITE (SEE 1997 REPORT) 47,49

GUAZATINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13516-27-3 OT FU RE JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 NO ADI 80,82 1978 0-0.03 30,31

HALOXYFOP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 69806-34-4 OC HC HB JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.0003 74,76

HCB SEE HEXACHLOROBENZENE

HCH SEE BHC

HEPTACHLOR / HEPTACHLOR EPOXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 76-44-8; 1024-57-3 OC CO 38 14 19 5 20 53 79 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0.0001 (PTDI) 71 1991 0-0.0001 62,64 1970 0-0.0005 14,15 1966 0-0.0005 6,7 1965 NO ADI 3,4 1963 NO ADI 2

[see Annex 1 for explanation of abbreviations] Page 38 IPCS and other WHO pesticide evaluations

HEXACHLOROBENZENE / HCB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 118-74-1 OC FU 107 26 20 79 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1978 COND ADI WITHDRAWN 30,31 1974 0-0.0006 CONDITIONAL 22,23 1973 NO ADI INTAKE OF 0.0006 MG/KG BW DAILY IS CONSIDERED BELOW ANY 20,21 DOSAGE RATE KNOWN TO BE HARMFUL 1969 0-0.0006 TENTATIVE NEGLIGIBLE DAILY INTAKE 12,13

HEXACHLOROCYCLOHEXANE SEE LINDANE OR BHC / HCH

HEXACONAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 79983-71-4 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1990 0-0.005 59,61 HEXYTHIAZOX

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 78578-05-0 HC AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1991 0-0.03 62,64

HYDROGEN CYANIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 74-90-8 OT FM IN RO JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1965 0-0.05 3,5

HYDROGEN PHOSPHIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7803-51-2 OT FM IN RO 73* 28* 46* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1966 ADI NOT NECESSARY ON BASIS OF NO RESIDUE IN FOOD 6,7 1965 NO ADI 3,5

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 39

IMIDACLOPRID

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 138261-41-3 OT IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.06 ACUTE RfD: 0.4 MG/KG BW 92,94

IMAZALIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 35554-44-0 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.03 92,94 2000 0-0.03 ACUTE RfD UNNECESSARY 89,91 1991 0-0.03 62,64 1986 0-0.01 47,49 1985 0-0.01 TEMPORARY 44,46 1984 0-0.01 TEMPORARY 42,43 1980 0-0.01 TEMPORARY 34,35 1977 0-0.01 TEMPORARY 28,29

IPRODIONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 36734-19-7 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.06 74,76 1992 0-0.2 65,67 1977 0-0.3 28,29

ISOFENPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 25311-71-1 OP IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.001 47,49 1982 0-0.0005 TEMPORARY 38,39 1981 0-0.0005 TEMPORARY 36,37

ISOPROTURON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 34123-59-6 UR HB *

[see Annex 1 for explanation of abbreviations] Page 40 IPCS and other WHO pesticide evaluations

JODFENPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 18181-70-9 OP IN AC 43 *

KRESOXIM-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 143390-89-0 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.4 ACUTE RfD UNNECESSARY 83,85

LEAD ARSENATE SEE ARSENATE, CALCIUM & LEAD

LEPTOPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 21609-90-5 OP IN 38 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1978 TEMP ADI WITHDRAWN 30,31 1975 0-0.001 TEMPORARY 24,25 1974 NO ADI 22,23

LINDANE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 58-89-9 OC IN 124 54 12 5* 20* 42* * * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.005 ACUTE RfD: 0.06 MG/KG BW 95,97 1997 0-0.001 TEMPORARY 80,82 1989 0-0.008 56,58 1977 0-0.01 28,29 1973 0-0.01 TEMPORARY 20,21 1970 0-0.0125 14,17 1966 0-0.0125 EVALUATED UNDER GAMMA-BHC 6,7 1965 0-0.0125 4 1963 0-0.0125 2

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 41

MALATHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 121-75-5 OP IN AC 29 30 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.3 80,82 1966 0-0.02 6,7 1965 0-0.02 3,4 1963 0-0.02 2

MALEIC HYDRAZIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 123-33-1; 10071-13-3 HC PG HB 4 42 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.3 77,79 1984 0-5 SODIUM OR POTASSIUM SALTS, 99.9% PURE & NOT MORE THAN 42,43 1 MG HYDRAZINE / KG 1980 0-1 TEMPORARY SODIUM OR POTASSIUM SALTS, 99.9% PURE & NOT MORE THAN 34,35 1 MG HYDRAZINE / KG 1976 NO ADI SODIUM OR POTASSIUM SALTS, 99.9% PURE & NOT MORE THAN 26,27 1 MG HYDRAZINE / KG

MANCOZEB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 8018-01-7 TC FU 78 94* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 GROUP ADI WITH MANEB, METIRAM & ZINEB 68,70 1980 0-0.05 LISTED UNDER DITHIOCARBAMATES; INDIVIDUALLY OR THE SUM OF 34,35 MANCOZEB, MANEB & ZINEB 1977 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF MANCOZEB, MANEB 28,29 & ZINEB 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY APPLICABLE TO THE PARENT COMPOUNDS ONLY & THE SUM OF ALL 14,15 ETHYLENE BISDITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY ALONE OR IN COMBINATION WITH OTHER ETHYLENE 8,9 BISDITHIOCARBAMATES (MANEB & ZINEB)

[see Annex 1 for explanation of abbreviations] Page 42 IPCS and other WHO pesticide evaluations

MANEB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 12427-38-2 TC FU 78 94* 12 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 GROUP ADI WITH MANCOZEB, METIRAM & ZINEB 68,70 1980 0-0.05 LISTED UNDER DITHIOCARBAMATES; INDIVIDUALLY OR THE SUM OF 34,35 MANCOZEB, MANEB & ZINEB 1977 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF MANCOZEB, MANEB 28,29 & ZINEB 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF ALL DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY LISTED UNDER DITHIOCARBAMATES; APPLICABLE TO THE PARENT 14,15 COMPOUNDS ONLY & TO THE SUM OF ALL THE DITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY ALONE OR IN COMBINATION WITH OTHER ETHYLENE 8,9 BISDITHIOCARBAMATES (MANCOZEB & ZINEB) 1965 NO ADI 4 1963 NO ADI 2

MCPA

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 94-74-6 PO HB 30 41 *

MECARBAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2595-54-2 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.002 47,49 1985 0-0.0005 TEMPORARY 44 1983 0-0.001 TEMPORARY 40,41 1980 0-0.001 TEMPORARY 34,35

MECOPROP

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7085-19-0 PO HB *

METALAXYL AND METALAZYL-M

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 57837-19-1 OT FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.08 GROUP ADI FOR METALAXYL AND METALAXYL-M 95,97 ACUTE RfD: UNNECESSARY 1982 0-0.03 38,39

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 43

METALDEHYDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 108-62-3 HC MO 93

METHACRIFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 30864-28-9; 62610-77-9 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1990 0-0.006 59,61 1988 0-0.003 TEMPORARY 53,55 1986 0-0.0003 TEMPORARY 47,49 1982 0-0.0003 TEMPORARY 38,39 1980 0-0.0003 TEMPORARY 34,35

METHAMIDOPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 10265-92-6 OP IN AC 79 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.004 ACUTE RfD: 0.01 MG/KG BW 95,97 1990 0-0.004 59,61 1985 0-0.0006 44,46 1982 0-0.0004 TEMPORARY 38,39 1976 0-0.002 26,27

METHIDATHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 950-37-8 OP HC IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.001 (1992) ACUTE RFD: 0.01 MG/KG BW 80,82 1992 0-0.001 65,67 1975 0-0.005 24,25 1972 0-0.005 TEMPORARY 18,19

[see Annex 1 for explanation of abbreviations] Page 44 IPCS and other WHO pesticide evaluations

METHIOCARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2032-65-7 CB MO IN AC RE JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.02 ACUTE RfD: 0.02 MG/KG BW 83,85 1987 0-0.001 50 1985 0-0.001 44,46 1984 0-0.001 42 1983 0-0.001 40,41 1981 0-0.001 36,37

METHOMYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 16752-77-5 CB IN AC 178 97 55 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.02 ACUTE RfD: 0.02 MG/KG BW 92,94 1994 0-0.03 SEE ANNEX 3 1989 0-0.03 56,58 1986 0-0.01 TEMPORARY 47,49 1978 NO ADI 30

METHOPRENE AND S-METHOPRENE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 40596-69-8 OT IG 47 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.09 RACEMATE ACUTE RfD UNNECESSARY (RACEMIC METHOPRENE 92,94 0-0.05 S-METHOPRENE AND S-METHOPRENE) 1987 0-0.1 50 1984 0-0.06 TEMPORARY 42,43

METHOXYCHLOR

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 72-43-5 OC IN 28 5 20 * * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1977 0-0.1 28,29 1965 0-0.1 4 1963 0-0.1 2

2-METHOXYETHYLMERCURY CHLORIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 123-88-6 SN FU 66

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 45

METHYL BROMIDE SEE BROMOMETHANE

METHYL PARATHION SEE PARATHION-METHYL

METIRAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 9006-42-2 TC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 GROUP ADI WITH MANCOZEB, MANEB & ZINEB 68,70

METOLACHLOR

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 51218-45-2 OC HB *

MEVINPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7786-34-7 OP IN AC 14 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.0008 (1996) ENVIRONMENTAL ASSESSMENT 80,82 1996 0-0.0008 ACUTE RfD: 0.003 MG/KG BW 77,79 1972 0-0.0015 18,19 1965 NO ADI 4 1963 NO ADI 2

MGK 264

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 113-48-4 HC SY JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1967 NO ADI 8,9

MIREX

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2385-85-5 OC IN 44 39 5 20

[see Annex 1 for explanation of abbreviations] Page 46 IPCS and other WHO pesticide evaluations

MOLINATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2212-67-1 TC HB *

MONOCROTOPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 6923-22-4 OP IN AC 80 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.0006 (1993) ACUTE RfD: 0.002 MG/KG BW 74,76 1993 0-0.0006 68,70 1991 0-0.00005 62,64 1975 0-0.0006 24,25 1972 0-0.0003 18,19

MYCLOBUTANIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 88671-89-0 HC OC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.03 65,67

NABAM (CONVERTED INTO ZINEB WHEN USED WITH ZINC SULFATE)

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 142-59-6 TC FU AL 78 94 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1977 TEMP ADI WITHDRAWN LISTED UNDER DITHIOCARBAMATES 28,29 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF ALL DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY LISTED UNDER DITHIOCARBAMATES; APPLICABLE TO THE PARENT 14,15 COMPOUNDS ONLY & TO THE SUM OF ALL DITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY AS ZINEB ALONE OR IN COMBINATION WITH OTHER ETHYLENE 8,9 BISDITHIOCARBAMATES (MANCOZEB, MANEB & ZINEB) 1965 NO ADI 4 1963 NO ADI 2

NALED

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 300-76-5 OP IN AC 39

NICLOSAMIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 50-65-7 DN OC MO 63 *

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 47

NITROFEN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1836-75-5 OC HB 84 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1983 NO ADI 40,41

OMETHOATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1113-02-6 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 ADI WITHDRAWN 77 1985 0-0.0003 44,46 1981 0-0.0005 TEMPORARY 36,37 1979 0-0.0005 TEMPORARY 32,33 1978 0-0.0005 TEMPORARY 30,31 1975 0-0.0005 TEMPORARY 24,25 1971 0-0.0005 TEMPORARY 16,17

OPP / SOPP SEE PHENYLPHENOL, 2- & ITS SODIUM SALT

ORGANOMERCURY COMPOUNDS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other HG FU 1* 86* 66* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1967 NO ADI 8,9 1966 NO ADI 6,7 1965 NO ADI 4 1963 NO ADI 2

OXAMYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 23135-22-0 CB AM IN AC NE 54 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.009 ACUTE RfD: 0.009 MG/KG BW 95,97 1985 0-0.03 44,46 1984 0-0.03 42,43 1983 0-0.01 TEMPORARY 40 1980 0-0.01 TEMPORARY 34,35

[see Annex 1 for explanation of abbreviations] Page 48 IPCS and other WHO pesticide evaluations

OXYDEMETON-METHYL / DEMETON-S-METHYL SULFOXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 301-12-2 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 ACUTE RfD: 0.002 MG/KG BW 95,97 1989 EVALUATED UNDER DEMETON-S-METHYL & RELATED COMPOUNDS 56,58 1984 NO ADI 42,43 1982 EVALUATED UNDER DEMETON-S-METHYL & RELATED COMPOUNDS 38 1973 EVALUATED UNDER DEMETON-S-METHYL & RELATED COMPOUNDS 20,21 1968 ADI WITHDRAWN 10,11 1967 0-0.0025 8,9 1965 0-0.0025 4 1963 0-0.0025 2

OXYTHIOQUINOX SEE CHINOMETHIONAT

PACLOBUTRAZOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 76738-62-0 HC PG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1988 0-0.1 53,55

PARAQUAT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 4685-14-7 HC HB 39 51 4 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.004 AS PARAQUAT ION 47,49 1985 0-0.0007 TEMPORARY AS PARAQUAT ION 44 1982 0-0.0007 TEMPORARY AS PARAQUAT ION 38,39 1976 0-0.0014 AS PARAQUAT ION 26,27 1972 0-0.0014 AS PARAQUAT ION 18,19 1970 0-0.0007 TEMPORARY AS PARAQUAT ION 14,15

PARATHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 56-38-2 OP IN AC 74 6 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.004 ACUTE RfD: 0.01 MG/KG BW 74,76 1967 0-0.005 8,9 1965 0-0.005 3,4 1963 0-0.005 2

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 49

PARATHION-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 298-00-0 OP IN AC 145 * 75* 7 30* JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.003 ACUTE RfD: 0.03 MG/KG BW 74,76 1984 0-0.02 42,43 1982 0-0.001 TEMPORARY 38,39 1980 0-0.001 TEMPORARY 34,35 1979 0-0.001 TEMPORARY 32,33 1975 0-0.001 TEMPORARY 24,25 1972 0-0.001 TEMPORARY 18,19 1968 0-0.001 TEMPORARY 10,11 1965 0-0.01 4 1963 0-0.01 2

PENCONAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 66246-88-6 HC OC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.03 65,67

PENDIMETHALIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 40487-42-1 DN HB *

PENTACHLOROPHENOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 87-86-5 OC IN FU HB 71 19 20 53 * **

PERMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 52645-53-1 PY IN 94 33 51 53 * * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.05 (1999) ACUTE RfD: 1.5 MG/KG BW 95 1999 0-0.05 FOR TECHNICAL-GRADE PERMETHRIN WITH CIS:TRANS RATIOS 86,88 OF 25:75 TO 40:60; ACUTE RfD UNNECESSARY 1987 0-0.05 FOR THE NOMINAL 40% CIS-, 60% TRANS- & 25% CIS-, 75% TRANS- 50,52 MATERIALS 1986 0-0.05 FOR THE NOMINAL 40% CIS-, 60% TRANS- MATERIAL ONLY 47 1982 0-0.05 FOR THE NOMINAL 40% CIS-, 60% TRANS- MATERIAL ONLY 38 1981 0-0.03 TEMPORARY 36,37 1979 0-0.03 TEMPORARY 32,33

[see Annex 1 for explanation of abbreviations] Page 50 IPCS and other WHO pesticide evaluations

PHENOTHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 26002-80-2 PY IN 96 32 85 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1988 0-0.07 20:80 CIS-TRANS RATIO; ADI APPLIES TO "d-PHENOTHRIN" 53,55 1984 0-0.04 TEMPORARY 20:80 CIS-TRANS RATIO; ADI APPLIES TO "d-PHENOTHRIN" 42,43 1982 0-0.2 TEMPORARY 20:80 CIS-TRANS RATIO 38 1980 0-0.2 TEMPORARY 20:80 CIS-TRANS RATIO 34,35

PHENTHOATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2597-03-7 OP IN AC 48 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1984 0-0.003 42,43 1980 0-0.001 TEMPORARY 34,35

PHENYLMERCURIC ACETATE SEE ORGANOMERCURY COMPOUNDS

2-PHENYLPHENOL & ITS SODIUM SALT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 90-43-7; 132-27-4 OT FU 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.4 ACUTE RfD UNNECESSARY (CONFIRMED BY 2002 JMPR) 86,88,95 1990 0-0.02 59,61 1989 0-0.02 TEMPORARY 56 1985 0-0.02 TEMPORARY 44,46 1983 0-0.02 TEMPORARY 40 1969 0-1.0 12,13

PHORATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 298-02-2 OP IN AC NE 75 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.0005 77,79 1994 0-0.0005 71,73 1985 0-0.0002 44,46 1983 0-0.0002 TEMPORARY 40 1982 0-0.0002 TEMPORARY 38,39 1977 NO ADI 28,29

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 51

PHOSALONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2310-17-0 OP HC IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.02 (1997) ACUTE RfD: 0.3 MG/KG BW 92,94 1997 0-0.02 80,82 1993 0-0.001 68,70 1972 0-0.006 18,19

PHOSMET

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 732-11-6 OP HC IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.01 ACUTE RfD: 0.02 MG/KG BW 83,85 1994 0-0.01 71,73 1979 0-0.02 32,33 1978 0-0.005 TEMPORARY 30,31

PHOSPHAMIDON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13171-21-6 OP IN AC 74 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.0005 47,49 1985 0-0.0005 TEMPORARY 44 1982 0-0.001 TEMPORARY 38,39 1968 0-0.001 10,11 1966 0-0.001 6,7 1965 NO ADI 4 1963 NO ADI 2

PHOSPHINE SEE HYDROGEN PHOSPHIDE

PHOXIM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 14816-18-3 OP IN 31 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.004 JECFA EVALUATION SEE ANNEX 3 1984 0-0.001 42,43 1982 0-0.0005 TEMPORARY 38,39

[see Annex 1 for explanation of abbreviations] Page 52 IPCS and other WHO pesticide evaluations

PIPERONYL BUTOXIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 51-03-6 HC SY 30 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.2 (1995) ACUTE RfD UNNECESSARY 92 1995 0-0.2 74,76 1992 0-0.03 65,67 1972 0-0.03 18,19 1966 0-0.03 TEMPORARY 6,7 1965 NO ADI 3,4

PIRIMICARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 23103-98-2 CB HC IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1982 0-0.02 38,39 1981 0-0.01 TEMPORARY 36,37 1978 0-0.01 TEMPORARY 30,31 1976 0-0.004 TEMPORARY 26,27

PIRIMIPHOS-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 29232-93-7 OP HC IN AC 49 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.03 65,67 1976 0-0.01 26,27 1974 0-0.005 TEMPORARY 22,23

PROCHLORAZ

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 67747-09-5 OC HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.01 ACUTE RfD: 0.1 MG/KG BW 92,94 1983 0-0.01 40,41

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 53

PROCYMIDONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 32809-16-8 OC HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 0-0.1 56,58 1982 NO ADI 38 1981 NO ADI 36,37

PROFENOFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 41198-08-7 OP IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1990 0-0.01 59,61

PROPACHLOR

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1918-16-7 OC HB 147 77 78

PROPAMOCARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 24579-73-5 CB FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1986 0-0.1 47,49 1984 0-0.02 TEMPORARY 42,43

PROPANIL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 709-98-8 OC HB *

PROPARGITE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2312-35-8 PO AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.01 ACUTE RfD UNNECESSARY (CONFIRMED BY 2002 JMPR) 86,88,95 1982 0-0.15 38,39 1980 0-0.08 TEMPORARY 34,35 1977 0-0.08 TEMPORARY 28,29

[see Annex 1 for explanation of abbreviations] Page 54 IPCS and other WHO pesticide evaluations

PROPHAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 122-42-9 CB HB PG 12 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 NO ADI 65,67 1965 NO ADI 3,4 1963 NO ADI 2

PROPICONAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 60207-90-1 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1987 0-0.04 50,52

PROPINEB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 12071-83-9; 9016-72-2 TC FU AC 78 94 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.007 68,70 1985 TEMP ADI WITHDRAWN 44,46 1983 0-0.005 TEMPORARY 40 1980 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES 34,35 1977 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES 28,29

PROPOXUR

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 114-26-1 CB IN 25 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 0-0.02 56,58 1973 0-0.02 20,21

PROPYLENETHIOUREA / PTU

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2122-19-2 UR 78 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.0003 ACUTE RfD: 0.003 MG/KG BW 86,88 1993 0-0.0002 TEMPORARY 68,70

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 55

PTU SEE PROPYLENETHIOUREA

PYRAZOPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13457-18-6 OP HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.004 65,67 1985 NO ADI 44

PYRETHRINS / PYRETHRUM EXTRACT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 8003-34-7 PY IN AC 11 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1999 0-0.04 ACUTE RfD: 0.2 MG/KG BW 86,88 1972 0-0.04 18,19 1970 0-0.04 TEMPORARY 14,15 1966 0-0.04 TEMPORARY 6,7 1965 NO ADI 3,4

PYRIDATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 55512-33-9 HC OC HB *

PYRIPROXYFEN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 95737-68-1 PO IG,IN * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.1 (1999) CONSIDERED FOR DIRECT ADDITION TO DRINKING-WATER FOR 92 MOSQUITO CONTROL: THE MEETING CONCLUDED THAT INTAKE OF PYRIPROXYFEN AT THE TARGET CONCENTRATION WOULD NOT PRESENT AN APPRECIABLE TOXICOLOGICAL RISK 1999 0-0.1 ACUTE RfD UNNECESSARY 86,88

[see Annex 1 for explanation of abbreviations] Page 56 IPCS and other WHO pesticide evaluations

QUINTOZENE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 82-68-8 OC FU 41 23 5 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.01 FOR QUINTOZENE CONTAINING LESS THAN 0.1% HEXACHLOROBENZENE 74,76 1977 0-0.007 28,29 1975 0-0.007 24,25 1973 0-0.001 TEMPORARY 20,21 1969 0-0.001 TEMPORARY 12,13

RESMETHRINS (RESMETHRIN, BIORESMETHRIN, CISRESMETHRIN)

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other PY IN 92 25 83

RODENTICIDES, ANTICOAGULANT

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other OT RO 175

ROTENONE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 83-79-4 HC IN AC 73

SIMAZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 122-34-9 HC HB 73 *

SODIUM FLUOROACETATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 62-74-8 OT RO IN 16

SPINOSAD

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 131929-60-7;131929-63-0 OT IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.02 ACUTE RfD UNNECESSARY 92,94

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 57

2,4,5-T

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 93-76-5 PO HB 13 15 41 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1981 0-0.03 CONTAINING NOT MORE THAN 0.01 MG TETRACHLORODIBENZODIOXIN 36,37 (TCDD) / KG 1979 0-0.003 TEMPORARY 32,33 1970 NO ADI 14,15

TEBUCONAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 107534-96-3 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.03 71,73

TEBUFENOZIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 112410-23-8 OT IG IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2001 0-0.02 (1996) ACUTE RfD: 0.05 MG/KG BW 92 1996 0-0.02 77,79

TECNAZENE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 117-18-0 OC FU PG 42 12 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.02 71,73 1983 0-0.01 40 1981 0-0.01 TEMPORARY 36,37 1978 0-0.01 TEMPORARY 30,31 1974 NO ADI 22,23

TEFLUBENZURON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 83121-18-0 UR IG JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.01 71,73

[see Annex 1 for explanation of abbreviations] Page 58 IPCS and other WHO pesticide evaluations

TEMEPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 3383-96-8 OP IN 8 *

TERBUFOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 13071-79-9 OP IN NE JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 0-0.0002 56,61

TERBUTHYLAZINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 5915-41-3 HC HB **

TETRADIFON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 116-29-0 OC AC 67 11

TETRAMETHRIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7696-12-0 PY IN 98 31

THALLIUM SULFATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 7446-18-6 OT RO IN 182 102 10

THIABENDAZOLE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 148-79-8 HC FU AN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.1 (1997) ACUTE RfD: 0.1 MG/KG BW (JECFA EVALUATION) SEE ANNEX 3 1997 0-0.1 JECFA EVALUATION SEE ANNEX 3 1992 0-0.1 JECFA EVALUATION SEE ANNEX 3 1977 0-0.3 28,29 1970 0-0.05 14,15

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 59

THIODICARB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 59669-26-0 CB IN MO JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.03 ACUTE RfD: 0.04 MG/KG BW 89,91 1986 0-0.03 47,49 1985 0-0.01 TEMPORARY 44,46

THIOMETON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 640-15-3 OP IN AC 67 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1979 0-0.003 32,33 1973 0-0.005 TEMPORARY 20,21 1969 NO ADI 12,13

THIOPHANATE-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 23564-05-8 CB FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1998 0-0.08 ACUTE RfD UNNECESSARY 83,85 1995 0-0.02 ENVIRONMENTAL ASSESSMENT ALSO PERFORMED 74,76 1977 0-0.08 28,29 1975 0-0.08 24,25 1973 0-0.08 20,21

THIRAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 137-26-8 TC FU RE 78 71 12 53 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1992 0-0.01 65,67 1987 NO ADI 50 1985 TEMP ADI WITHDRAWN 44 1980 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES 34,35 1977 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES 28,29 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF ALL DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY LISTED UNDER DITHIOCARBAMATES; APPLICABLE TO THE PARENT 14,15 COMPOUNDS ONLY & TO THE SUM OF ALL THE DITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY ALONE OR IN COMBINATION WITH OTHER 8,9 DIMETHYLDITHIOCARBAMATES (FERBAM & ZIRAM) 1965 0-0.025 4 1963 0-0.025 2

[see Annex 1 for explanation of abbreviations] Page 60 IPCS and other WHO pesticide evaluations

TIN & ORGANOTIN COMPOUNDS SEE FENTIN COMPOUNDS

TOLCLOFOS-METHYL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 57018-04-9 OP FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1994 0-0.07 71,73

TOLYLFLUANID

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 731-27-1 OT FU AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.08 ACUTE RfD: 0.5 MG/KG BW 95,97 1988 0-0.1 53,55

TOXAPHENE SEE CAMPHECHLOR

TRI-ALLATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2303-17-5 TC HB 89

TRIADIMEFON

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 43121-43-3 PO HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1985 0-0.03 44,46 1983 0-0.01 TEMPORARY 40,41 1981 0-0.01 TEMPORARY 36,37

TRIADIMENOL

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 55219-65-3 PO HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 0-0.05 56,58

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 61

TRIAZOLYLALANINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other HC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1989 ADI NOT NECESSARY METABOLITE OF TRIAZOLE PESTICIDES 56,58

TRIAZOPHOS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 24017-47-8 OP HC IN AC NE JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2002 0-0.001 ACUTE RfD: 0.001 95,97 1993 0-0.001 68,70 1991 0-0.0002 TEMPORARY 62,64 1986 0-0.0002 TEMPORARY 47,49 1982 0-0.0002 TEMPORARY 38,39

TRIBUTYLTIN COMPOUNDS

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other SN MO 116 CICAD 14

TRICHLORFON (METRIFONATE)

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 52-68-6 OP IN 132 66 27 30 * JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

2000 0-0.02 JECFA EVALUATION SEE ANNEX 3 1978 0-0.01 30,31 1975 0-0.005 TEMPORARY 24,25 1971 0-0.01 TEMPORARY 16,17

TRICHLORONATE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 327-98-0 OP IN JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1971 NO ADI 16,17

TRICYCLOHEXYLTIN HYDROXIDE SEE CYHEXATIN

[see Annex 1 for explanation of abbreviations] Page 62 IPCS and other WHO pesticide evaluations

TRIFENMORPH

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1420-06-0 HC MO 64 *

TRIFLURALIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1582-09-8 DN HB 53 *

TRIFORINE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 26644-46-2 OC HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1997 0-0.02 80,82 1978 0-0.02 30,31 1977 NO ADI 28,29

TRIPHENYLTIN COMPOUNDS SEE FENTIN COMPOUNDS

VAMIDOTHION

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 2275-23-2 OP CB IN AC JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1988 0-0.008 53,55 1985 0-0.0003 TEMPORARY 44,46 1982 0-0.0003 TEMPORARY 38,39 1973 NO ADI 20,21

VINCLOZOLIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 50471-44-8 HC FU JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1995 0-0.01 74,76 1988 0-0.07 53,55 1986 0-0.04 TEMPORARY 47,49

WARFARIN

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 81-81-2 OT RO 175 96 35

[see Annex 1 for explanation of abbreviations] IPCS and other WHO pesticide evaluations Page 63

ZINC PHOSPHIDE

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 1314-84-7 OT RO 24

ZINEB

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 12122-67-7 TC FU 78 94* 12 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1993 0-0.03 GROUP ADI WITH MANCOZEB, MANEB & METIRAM 68,70 1980 0-0.05 LISTED UNDER DITHIOCARBAMATES; INDIVIDUALLY OR THE SUM OF 34,35 MANCOZEB, MANEB & ZINEB 1977 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF MANCOZEB, MANEB 28,29 & ZINEB 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF ALL DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY LISTED UNDER DITHIOCARBAMATES; APPLICABLE TO THE PARENT 14,15 COMPOUNDS ONLY & TO THE SUM OF ALL THE DITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY ALONE OR IN COMBINATION WITH OTHER ETHYLENE 8,9 BISDITHIOCARBAMATES (MANCOZEB, MANEB & ZINEB) 1965 NO ADI 4 1963 NO ADI 2

ZIRAM

Chemical Data DW CAS Reg. No. class Use EHC HSG sheet IARC GVs Specs Other 137-30-4 TC FU RE 78 73 12 53 JMPR evaluations Year of Reference evaluation ADI (mg/kg bw) Comments (see Annex 2)

1996 0-0.003 GROUP ADI FOR FERBAM AND ZIRAM 77,79 1980 0-0.02 LISTED UNDER DITHIOCARBAMATES; SUM OF FERBAM & ZIRAM 34,35 1977 0-0.02 LISTED UNDER DITHIOCARBAMATES; SUM OF FERBAM & ZIRAM 28,29 1974 0-0.005 TEMPORARY LISTED UNDER DITHIOCARBAMATES; SUM OF ALL DITHIOCARBAMATES 22,23 1970 0-0.025 TEMPORARY LISTED UNDER DITHIOCARBAMATES; APPLICABLE TO THE PARENT 14,15 COMPOUNDS ONLY & TO THE SUM OF ALL THE DITHIOCARBAMATE FUNGICIDES 1967 0-0.025 TEMPORARY ALONE OR IN COMBINATION WITH OTHER 8,9 DIMETHYLDITHIOCARBAMATES (FERBAM & THIRAM) 1965 NO ADI 4 1963 NO ADI 2

[see Annex 1 for explanation of abbreviations] ANNEX 1

1. Codes for chemical class

AM acid amide OP organophosphorus/organothiophosphorus AS arsenic compound OT other BR bromide PO phenoxy CB carbamate PY pyrethroid DN dinitrophenol/dinitrophenolate SN organotin HC heterocyclic TC thiocarbamate HG organomercury UR urea OC organochlorine

2. Codes for use

AC acaricide, miticide IN insecticide AL algicide MO molluscicide AN anthelminthic NE nematicide BA bacteriocide OT other CO contaminant PG plant growth regulator FM fumigant RE repellent FU fungicide RO rodenticide HB herbicide SY synergist IG insect growth regulator TE termiticide

3. Abbreviations

ACUTE RfD acute reference dose ADI acceptable daily intake CAS Reg. No. Chemical Abstracts Service Registry Number CICAD concise international chemical assessment document COND ADI conditional ADI (no longer allocated to pesticides) Data sheet WHO/FAO Data Sheet on Pesticides DW GLs WHO Guidelines for Drinking-Water Quality EHC environmental health criteria monograph HSG health and safety guide IARC International Agency for Research on Cancer PTDI provisional tolerable daily intake Specs WHO specifications for pesticides used in public health TEMP ADI temporary ADI

4. Information on individual documents (see Introduction for descriptions of them)

a. Environmental Health Criteria (EHC) monographs

The number refers to the number of the publication in the WHO Environmental Health Criteria series. An asterisk (*) indicates that a synonym rather than the common name is used in the publication. In some cases the EHC publication includes a broader subject area than the listed pesticide. EHC publications are available through the network of WHO Sales Agents or from WHO Marketing and Dissemination. A free catalogue of EHC publications is available upon request from WHO Marketing and Dissemination.

b. Health and Safety Guides (HSGs)

The number refers to the publication number. An asterisk (*) indicates that a synonym rather than the common name is used in the publication. HSGs are available through the network of WHO Sales Agents or from WHO Marketing and Dissemination. The catalogue of EHC publications contains a list of available HSGs.

c. WHO/FAO Data Sheets on Pesticides

An asterisk (*) indicates that a synonym rather than the common name is used to identify the data sheet. Pesticide data sheets are available from the Director, International Programme on Chemical Safety.

Page 1 Annex 1

d. IARC monographs

The number refers to the number of the publication in the International Agency for Research on Cancer Monograph Series. An asterisk (*) indicates that a synonym rather than the common name is used in the publication. IARC monographs are available through the network of WHO Sales Agents or from WHO Marketing and Dissemination.

e. WHO Guidelines for Drinking-Water Quality

Information on the pesticides identified by a single asterisk (*) in the DW GVs (drinking-water guideline values) field may be found in two publications, both of which are available from the network of WHO Sales Agents or from WHO Marketing and Dissemination: Guidelines for drinking-water quality, second edition, volume 1, Recommendations, World Health Organization, 1993. Guidelines for drinking-water quality, second edition, volume 2, Health criteria and other supporting information, World Health Organization, 1996.

Pesticides identified by a double asterisk (**) in the DW GVs field are included in the first addendum to the second edition of Volume 1, Recommendations, of the Guidelines for drinking-water quality, which is available from WHO Marketing and Dissemination.

f. Specifications for pesticides used in public health

The latest WHO specifications are those found in Specifications for pesticides used in public health, seventh edition, WHO/CTD/WHOPES/97.1 and Interim specifications for pesticides used in public health, WHO/CTD/WHOPES/97.7 and WHO/CTD/WHOPES/98.8. The three documents may be obtained from the WHO Pesticide Evaluation Scheme, Commicable Diseases Control, Prevention and Eradication.

5. Addresses for obtaining documents and publications

a. Marketing and Dissemination World Health Organization d. Chief 20, Avenue Appia Joint FAO/WHO Food Standards CH-1211 Geneva 27 Programme Switzerland Food Quality and Standards Service fax: (+41 22)791 4957 Food and Nutrition Division www.who.int/dsa/ Food and Agriculture Organization of the [email protected] United Nations Via delle Terme di Caracalla b. Distribution and Sales Unit I-00100 Rome Food and Agriculture Organization of Italy the United Nations fax: (+39 06)5225 4593/3152 Via delle Terme di Caracalla www.codexalimentarius.net/ I-00100 Rome [email protected] Italy fax: (+39 06)5225 3152 e. Communicable Diseases Control, www.fao.org/catalog/giphome.htm Prevention, and Eradication [email protected] WHO Pesticide Evaluation Scheme (WHOPES) c. Coordinator World Health Organization International Programme on 20, Avenue Appia Chemical Safety CH-1211 Geneva 27 World Health Organization Switzerland 20, Avenue Appia fax: (+41 22)791 4777 CH-1211 Geneva 27 www.who.int/ctd/whopes/ Switzerland fax: (+41 22)791 4848 www.who.int/pcs/ [email protected]

Page 2

ANNEX 3

1. JECFA evaluations

The Joint FAO/WHO Expert Committee on Food Additives (JECFA) has evaluated several pesticides that are also used as veterinary drugs. The results of the toxicological evaluations are included under the individual substances in the summary of toxicological evaluations performed by JMPR in this inventory. Information on the publications is provided here. Substance Meeting Year Report Toxicological Residue monograph monograph

Cyfluthrin Forty-eighth 1997 TRS1 879, 1998 FAS2 39, 1997 FNP3 41/10, 1998 Cyhalothrin Fifty-fourth 2000 TRS1 900, 2001 FAS2 45, 2000 FNP3 41/13, 2000 Fifty-eighth 2002 TRS1 911, 2002 no monograph no monograph Cypermethrin Forty-seventh 1996 TRS1 876, 1998 FAS2 38, 1996 FNP3 41/9, 1997 Fifty-fourth 2000 TRS1 900, 2001 residues only FNP3 41/13, 2000 Fifty-eighth 2002 TRS1 911, 2002 residues only FNP3 41/14, 2002 "-Cypermethrin Forty-seventh 1996 TRS1 876, 1998 FAS2 38, 1996 FNP3 41/9, 1997 Fifty-fourth 2000 TRS1 900, 2001 residues only FNP3 41/13, 2000 Fifty-eighth 2002 TRS1 911, 2002 residues only FNP3 41/14, 2002 Deltamethrin Fifty-second 1999 TRS1 893, 2000 residues only FNP3 41/12, 2000 Dicyclanil Fifty-fourth 2000 TRS1 900, 2001 FAS2 45, 2000 FNP3 41/13, 2000 Fluazuron Forty-eighth 1997 TRS1 879, 1998 FAS2 39, 1997 FNP3 41/10, 1998 Permethrin Fifty-fourth 2000 TRS1 900, 2001 residues only FNP3 41/13, 2000 Phoxim Fifty-second 1999 TRS1 893, 2000 FAS2 43, 1999 FNP3 41/12, 2000 Fifty-eighth 2002 TRS1 911, 2002 residues only FNP3 41/14, 2002 Thiabendazole Fortieth 1992 TRS1 832, 1993 FAS2 31, 1993 FNP3 41/5, 1993 Forty-eighth 1997 TRS1 879, 1998 FAS2 39, 1997 FNP3 41/10, 1998 Fifty-eighth 2002 TRS1 911, 2002 FAS2 49, 2002 toxicity only Trichlorfon Fifty-fourth 2000 TRS1 900, 2001 FAS2 45, 2000 FNP3 41/13, 2000 (metrifonate) 1WHO Technical Report Series, available from WHO Marketing and Dissemination (see Annex 1 for address). 2WHO Food Additives Series, available from WHO Marketing and Dissemination (see Annex 1 for address). 3FAO Food and Nutrition Paper, available from FAO Distribution and Sales Section (see Annex 1 for address).

2.Core Assessment Group meetings

A Core Assessment Group meeting of the Joint Meeting on Pesticides (see section III of the introduction for a brief description of the JMP) was held in 1994, at which time five pesticides on which draft Environmental Health Criteria (EHC) monographs had been prepared were evaluated. These EHC monographs have been published as follows:

chlorothalonil EHC 183 diflubenzuron EHC 184 methomyl EHC 178 1,2-dibromomethane EHC 177 1,2-dichloroethane EHC 176

A report of the 1994 meeting of the Core Assessment Group that summarizes the evaluations was published shortly after the meeting (WHO/PCS/95.7), which is available from the Director of the International Programme on Chemical Safety (see Annex 1 for address).

The evaluations performed at these meetings are included under the individual substances in the summary of toxicological evaluations performed by JMPR in this inventory.