Curriculum Vitae Iman Abdel Salam Mansi

PERSONAL DETAILS Date of birth: 26th October, 1973 Nationality: Jordanian Gender: Female Address: 35 zuhair bin abisalma street- west Mousa Al-Hadban Mosque Abu Alia Avenue-Tareq region Amman- Jordan Mobile: +962 779694678 Email: [email protected]

EDUCATION AND QUALIFICATIONS PhD in Pharmaceutical Chemistry (2004-2008) Eberhard-Karls University, Tübingen, Germany Average: 2 (Good) Title of PhD thesis: Interdomain signal transduction in GAF tandem chimeras using the CyaB1 adenylyl cyclase as a reporter

Master in Pharmaceutical Technology (9/1998-8/2000) Jordan university of science and technology (JUST), Irbid-Jordan GPA: 87% (very good) Rank: the first between 11. Title of Master thesis: Evaluation of Hydroxyethyl diclofenac prodrug oral absorption

Bachelor of Science (Pharmacy) (9/1991-2/1996) Jordan university of science and technology (JUST), Irbid-Jordan GPA: 81.2 % (very good) Rank: the sixth between 107

General Secondary Education Certificate Examination (1991) Nour Al-Hussein Secondary school-Irbid- Jordan Average: 91.3%

TEACHING HISTORY 14/9/2014- now, Assistant professor at the Faculty of Pharmaceutical sciences, The Hashemite University, Zarqa, Jordan, teaching medicinal chemistry 1 and 2, Pharmacognosy, community Pharmacy 1 and 2, biochemistry, clinical biochemistry, pathophysiology and pharmaceutical Biotechnology 14/9/2016- 13/9/2018, Assistant dean at the Faculty of Pharmaceutical sciences, The Hashemite University, Zarqa, Jordan 2/9/2012-1/9/2013, Vice dean/Faculty of pharmacy, Zarqa University, Zarqa, Jordan 13/9/2010-12/9/2011, Assistant dean/ Faculty of pharmacy, Zarqa University, Zarqa, Jordan 13/9/2010-11/9/2014, Assistant professor at the Faculty of Pharmacy, Zarqa University, Zarqa, Jordan teaching pharmaceutical organic chemistry, medicinal chemistry 1 and 3, biochemistry and clinical biochemistry 27/9/2009-26/9/2010, Assistant professor at the Faculty of Pharmacy, Applied science University, Amman, Jordan teaching medicinal chemistry 2 and 3 5/10/2008-4/10/2009, Assistant professor at the Faculty of Pharmacy, Al-Isra Private University, Jordan, teaching medicinal chemistry, biochemistry and clinical biochemistry 11/2/2001-31/8/2004, Full-Time Lecturer, Faculty of Pharmacy, Jordan University of Science and Technology – Irbid – Jordan teaching medicinal chemistry lab., Organic chemistry lab., analytical chemistry lab., and clinical pharmacy lab 1/9/1996-31/1/2001, Teaching assistant (T.A.) Faculty of Pharmacy, Philadelphia University – Amman- Jordan, teaching pharmacognosy lab., phytochemistry lab., pharmaceutics lab., and industrial pharmacy lab

WORK SKILLS AND RESEARCH INTERESTS 1. Cloning and expression of proteins or enzymes using different strains of E.coli bacteria 2. Protein isolation, purification, concentration and crystallization and protein modeling 3. Protein detection techniques (SDS-PAGE, FPLC, and Western Blot) 4. Enzymatic assays 5. Tissue culture (Cytotoxicity studies, Melanin content and protein expression changes) 6. Studying the antibacterial activity and enzyme inhibitory activity for synthetic compounds and plant extracts 7. Basic computer skills (windows and MS office), and other computer programs as origin, DNA star, GENEDOC, RasTop (protein modelling), GraphPad Prism and ChemBioDraw 8. Languages: Arabic (Mother tongue), English (Excellent), German (good)

PUBLICATIONS 1. Iman Mansi, Mahmoud Al-Sha’er, Nizar Mhaidat, and Mutasem Taha (2020) Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents, Anticancer Agents in Medicinal Chemistry, 20, 1, https://doi.org/10.2174/1871520620666191224110600, Accepted for publication ((ISI impact factor=2.18). 2. Iman Mansi, Mahmoud Al-Sha’er, Nizar Mhaidat, Mutasem Taha and Rand Shahin (2020) Investigation of binding characteristics of Phosphoinositide-dependent kinase-1 (PDK1) co-crystallized ligands through virtual pharmacophore modeling leading to novel anti – PDK1 hits, Medicinal Chemistry, 16, 1-21. DIO: 10.2174/1573406415666190724131048 (ISI impact factor=2.53) 3. Iman Mansi, Nasser Awadh Ali, Nizar M. Mhaidat, Khaled Hussain, Ali G. Al-kaf, Sirajudheen Anwar, William N. Setzer (2019) Chemical Composition and Biological Activity of the Essential Oil Isolated from the Leaves of AchilleafragrantissimaGrowing Wild in Yemen, Pharmacognosy Journal, 11 (5), 1077-1081(Scopus) 4. Awadh Ali NA, Mansi I, Ahmed N, Alghamdi S, Alhalawah RA, Al-Khulaidi A, Anwar S. (2019) Ultra high performance liquid chromatography-electrospray ionization-mass spectroscopy quantification, xanthine oxidase inhibitory, and antioxidant activity profile of some medicinal plants from Albaha Region. Phcog Mag, 15, Suppl S1:162-7(ISI impact factor=1.260) 5. Nabil N. AL-Hashimi, Anas I. Awwad, Aqeel N. AL-Hashimi, Iman A. Mansi, Rand O. Shahin and Saja H. Hamed, Functionalized Multi Walled Carbon Nanotubes-Reinforced Hollow Fiber Solid/Liquid Phase Microextraction and HPLC-DAD for Determination of Phenazopyridine in Urine, Current Pharmaceutical Analysis, 2019, 15 (5), 447-455. DOI:10.2174/1573412914666180329153443(ISI impact factor=0.829) 6. Rajab Abu-El-Halawa, Mohammad M. Ibrahim, Fatheya B. Rabi, Mohammad A. Alkenji, Qosay Al-Balas, Iman A. Mansi, Mahmoud Al-Refai, (2018) Synthesis, Characterization and Biological Activity of 4-Imino-3-substituted-2-thioxo-1,2,3,4- tetrahydrobenzo[g]pteridine 5,10-dioxide, Jordan Journal of Chemistry, 13(1), 1-14 7. Rand Shahin, Iman Mansi, LubnaSwellmeen, TahaniAlwidyan, Nabil Al-Hashimi, Yaser Al- Qarar'h, Omar Shaheen, Ligand-Based Computer Aided Drug Design Reveals New Tropomycin Receptor Kinase A (TrkA) Inhibitors (2018)Journal of Molecular Graphics and Modelling, 80, 327-352. https://doi.org/10.1016/j.jmgm.2018.01.004(ISI impact factor=1.863) 8. PrabodhSatyal, Tyler H. Jones, Elizabeth M. Lopez, Robert L. McFeeters, Nasser A. Awadh Ali, Iman Mansi, Ali G. Al-kaf and William N. Setzer, Chemotypic Characterization and Biological Activity of Rosmarinus officinalis (2017) Foods, 2017, 6, 20; doi:10.3390/foods6030020(ISI impact factor=3.011) 9. Rowaida N. Al-Badani, Joyce Kelly R. da Silva, Iman Mansi, Bushra A. Muharam, William N. Setzer& Nasser A. Awadh Ali, Chemical Composition and Biological Activity of Lavandulapubescens Essential Oil from Yemen (2017) Journal of Essential Oil Bearing Plants, 20:2, 509-515, DOI: 10.1080/0972060X.2017.1322538(ISI impact factor=0.688) 10. SofianeHabibatni, AbdessalamFatma Zohra, Hani Khalida, Sirajudheen Anwar, Iman Mansi, Nasser A Ali. In-vitro antioxidant, Xanthine oxidase-inhibitory and in-vivo Anti- inflammatory, analgesic, antipyretic activity of Onopordumacanthium (2017). International Journal of Phytomedicine, 9(1) , mar. 2017. ISSN 0975-0185 11. Jamila I Dibas, Basma M Yaghi, Iman A Mansi, Nizar M Mhaidat, Khadeejah FS Al- Abrounie (2017) Screening for cytotoxic and antioxidant activity of selected wild plants at Shafa Badran, Amman, Jordan, Research Journal Of Pharmaceutical Biological And Chemical Sciences, 8(2), 489-497 12. Mahmoud A Al-Sha'er, Iman Mansi, MalakKhanfar, Alaaabudayyh, Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation, 2016, J EnzInhib Med Chem, DOI: 10.1080/14756366.2016.1218485(ISI impact factor=4.027) 13. Mahmoud A Al-Sha'er, Iman Mansi, Nancy Hakooz, Screening of miscellaneous Hsp90 inhibitors using virtual co-crystallized pharmacophore, J Comput Methods Mol Des, 2015, 5 (3):47-57 14. Mahmoud A Al-Sha'er, Iman Mansi, Inas Almazari, Nancy Hakooz, Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation. J Mol Graph Model, 2015, 22(62):213-25 (ISI impact factor=1.863) 15. Nizar Mhaidat,Mousa Al-Smadi, Fouad Al-momani, Karem Alzoubi, Iman Mansi, and Qosay Al-Balas, Synthesis, Antimicrobial and In vitro Antitumor Activities of a Series of 1,2,3-Thiadiazole and 1,2,3-Selenadiazole Derivatives, Drug design, development and therapy, 2015, 9: 3645-3652(ISI impact factor=3.208) 16. Mahmoud Al-Sha'er, Iman Mansi, Nancy Hakooz, docking and pharmacophore mapping of halogenated pyridinium derivatives on heat shock protein 90, J Chem Pharm Res, 2015, 7 (4), 103-112 17. Mahmoud Al-Sha'er, Iman Mansi, Nancy Hakooz, 1-[2-substituted ethyl]-2-methyl-5- nitroimidazole derivatives, synthesis and antibacterial activities, Der Pharma Chemica, 2013, 5(3): 156-162 (Scopus) 18. Idkaidek, NM, Jilani, JA, Mansi, IA, Evaluation of hydroxethyldiclofenac intestinal absorption in rats, Saudi Pharm J, 2005, 13 (4), 158-163(ISI impact factor=3.643)

CONFERENCES AND SCIENTIFIC DAYS 1. The Third Global Forum for Marketing of Halal Pharmaceuticals, Zarqa University, 7/1/2020 2. The sixth scientific day, Pharmacy profession: civilization and humanity, JPA/Zarqa Committee, 20/4/2019, organization committee/vice president and lecturer 3. The second Global Forum for Marketing of Halal Pharmaceuticals, Princess Sumaya University for Technology, 5/12/2018 4. The fifth scientific day, Pharmacy profession: Reality and outlook, JPA/Zarqa Committee, 8/4/2017, organization committee/vice president 5. The fourth scientific day, The expert pharmacist is your trusted consultant, JPA/Zarqa Committee, 16/5/2015, organization committee/ vice president 6. Third scientific day, Pharmacy: a bright face for a human profession, JPA/Zarqa Committee, 4/5/2013, organization committee/ vice president 7. Second Scientific day Jordan Pharmaceutical association/Zarqa committee, JPA, 22/4/2011 8. The fourth International conference on health care, Al-Ahlyya Amman University, 4- 5/5/2011, attendance 9. Von Humboldt Conference, Pharmaceutical and Biotechnological Therapies, German University in Cairo; Egypt, 29/9- 1/10/ 2012, Dimerization in the GAF domains of PDE2 and PDE5: Structure-function relationship, poster presentation 10. The fourth international conference, Al-Zaytoonah University of Jordan, 17-19/10/2012, attendance 11. The first scientific day, Pharmacy and our future aspirations, Faculty of Pharmacy/Zarqa University, 23/5/2013, organization and attendance

TRAINING and WORKSHOPS 1. Curriculum Development Workshop at The Faculty of Pharmacy, Zarqa University, 20/1/2019 2. ACPE Certification Workshop, The University of Jordan, 10/10/2017 3. Workshop in shaping the way we teach, Danish Jordanian University Cooperation and Language Center at Hashemite University, 15/3/2016 4. Course in higher education, Center of academic quality assurance/The Hashemite University-Jordan, 25-27/1/2015 5. Workshop about learning outcomes and employability in Pharmacy education, TEMPUS office, 19-20/1/2014 6. Training on Isolera Flash chromatography at Biotage company/Sweden 8-9th, March, 2012 7. Workshop about Ovid Database organized by TechKnowledge at Al-Ahliyya Amman University, 23/5/2011 8. Workshop about Abuse of hypnotic drugs, Jordan Pharmaceutical association/Zarqa committee, 14/12/2010 9. Technical seminar presented by Shimadzu application specialist, Amman, 4th, November, 2010 including the following subjects: a. Shimadzu Nexera HPLC which based on Ultra Fast Analysis. b. Shimadzu Advance Flow Technology in Gas Chromatography c. Shimadzu new Technology in AAS 10. Introduction into procedure for project proposals to EU institutions, AGEF, 6-7/12/2009 11. 10 hours in Total quality management and ISO, ASU, 22-28/2/2010 12. 12 hours in class management and educational methods, ASU, 9-11/2/2010