bioRxiv preprint doi: https://doi.org/10.1101/258608; this version posted February 1, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Candida albicans dispersed cells signify a developmental state distinct from biofilm and planktonic phases Priya Uppuluri1*, Maikel Acosta Zaldivar2, Matthew Z Anderson3, Matthew J. Dunn3, Judith Berman4, Jose Luis Lopez Ribot5 and Julia Koehler2* 1The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center, CA 2Division of Infectious Diseases, Children’s Hospital, Boston, MA 3Department of Microbiology, The Ohio State University, Columbus, OH 4Department of Molecular Microbiology & Biotechnology, Tel Aviv University, Ramat Aviv, Israel 5Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX *Co-Corresponding authors
[email protected] [email protected] bioRxiv preprint doi: https://doi.org/10.1101/258608; this version posted February 1, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract: Candida albicans surface-attached biofilms are sites of amplification of an infection through continuous discharge of cells capable of initiating new infectious foci. Yeast cells released from biofilms on intravenous catheters have direct access to the bloodstream.