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Swallowing Dysfunction in Patients with Esophageal Atresia- Tracheoesophageal Fistula: Infancy to Adulthood

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Swallowing Dysfunction in Patients with Esophageal Atresia- Tracheoesophageal Fistula: Infancy to Adulthood Editorial Page 1 of 6 Swallowing dysfunction in patients with esophageal atresia- tracheoesophageal fistula: infancy to adulthood Tutku Soyer Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey Correspondence to: Tutku Soyer, MD. Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Email: [email protected]. Provenance: This is an invited Editorial commissioned by Editor-in-Chief Dr. Changqing Pan (Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China). Comment on: Gibreel W, Zendalajas B, Antiel RM, et al. Swallowing dysfunction and quality of life in adults with surgically corrected esophageal atresia/tracheoesophageal fistula as infants. Ann Surg 2017;266:305-10. Received: 14 September 2017; Accepted: 21 September 2017; Published: 28 September 2017. doi: 10.21037/shc.2017.09.09 View this article at: http://dx.doi.org/10.21037/shc.2017.09.09 Introduction Definition of SD and dysphagia Esophageal dysfunction is a common problem in children Dysphagia is defined as swallowing disorder caused by with repaired esophageal atresia-tracheoesophageal fistula sensory-motor dysfunctions or structural pathology of oral, (EA-TEF) and considered as a long-term sequel of the pharyngeal and/or esophageal phases of bolus transport to cases. Impaired esophageal motility in EA survivors is the stomach (5). Gibreel et al. suggest that dysphagia mainly multifactorial and is attributed to primary abnormality of focus on difficulty of swallowing solid food and the term SD esophageal innervation and vagal nerve damage during includes difficulty swallowing to all food consistencies (3). esophageal repair (1). Dysphagia, regurgitation, aspiration In the letter definition, difficulty of thin or thick liquids and chronic respiratory tract infections are considered as may also assessed as SD. clinical findings of esophageal dysmotility (2). In addition to esophageal motility problems, 28% of patients with EA- Incidence TEF had oropharyngeal impairment causing swallowing dysfunction (SD) (2). Due to lack of objective criteria Feeding difficulties are common in children with EA and there is a wide variation in prevalence of SD in children they are more likely to eat slowly, refuse meals, cough and with EA-TEF. Gibreel et al. reported that 82% of cases choke during eating and vomit with meals. Chetcuti et al. show some degree of SD in adulthood and most of the noted that these difficulties lessen with age and only 10% of cases had mild symptoms that not affect the food choices them report these symptoms after age 15 (6). The incidence of patients (3). Another study evaluating the dysphagia in of dysphagia varies 15–52% in children (5) and 57% of adult EA survivors report dysphagia with a prevalence of adults with repaired EA complaint about dysphagia (4). A 57% by using a symptom score test (4). Dysphagia is the systematic meta-analysis by Conner et al. found that overall most common symptom in patients with EA of all ages and incidence of dysphagia is 50.3% (7). incidence is varying depending on the definition. It has been shown that incidence is lower in infants than children and Clinical findings of SD adults (5). Also, diagnostic methods that used to evaluate the dysphagia are responsible from the varying data. In this Children present with SD show wide spectrum of clinical review, definition, diagnostic methods and clinical course findings including gagging, vomiting and food refusal. of SD in patients with EA-TEF will be summarized from Different clinical findings can be seen in different phases infancy to adulthood. of deglutition (Table 1). By the age, most of the patients © Shanghai Chest. All rights reserved. shc.amegroups.com Shanghai Chest 2017;1:42 Page 2 of 6 Shanghai Chest, 2017 Table 1 Different clinical findings according to the effected phases of chronic respiratory airway disease in adulthood (13). In deglutition addition to esophageal motility problems, oropharyngeal Phases Disorders dysphagia (OPD) was observed in 28% of the EA cases and Feeding behaviour Feeding refusal, long mealtimes, late aspiration was detected in 55% of the patients with OPD (2). introduction to solid foods In patients with OPD, penetration and aspiration were also Oral preperatory Oral hypersensitivity, rumination detected with higher PAS scores in 15% of all cases. It has been demonstrated that delayed pharyngeal swallowing was Oral Oral hypersensitivity, oral motor an indicator of aspiration and dysphagia is considered as a impairment risk factor for respiratory problems (14). Pharyngeal Dyphagia, chocking, gagging, coughing, Although, there is no direct correlation between the aspiration type of atresia and pulmonary complications, patients Esophageal Dysphagia, regurgitaion, dysmotility, causing airway problems with long gap atresia or tensioned bolus impaction, reduced peristalsis anastomosis often have respiratory problems and dysphagia. In addition to structural anomalies, tensioned anastomosis or extensive mobilization of both pouches alter hyolaryngeal adapted their eating habits by eating slowly, longer chewing mobilization and cause aspiration (15). Aspiration during on solid foods, drinking after having swallowed solid foods swallowing is associated with esophageal dysmotility and/or and avoiding dry and hard solids. Therefore, feeding gastroesophageal reflux and may lead to reduced pulmonary difficulties show different clinical courses and causes variety functions and bronchiectasis (2). Early detection and of symptoms in different age periods. management of aspiration and thus protection of airways is mandatory to prevent pulmonary complications. Mechanisms of SD Diagnosis of SD Esophageal dysmotility is the main cause of SD in children with EA. The primary motility disorder relates either with The evaluation of SD can be performed by diagnostic the development of esophageal muscle or to the innervation tests and/or by symptom scoring questionnaires. Contrast of the esophagus (8). Neuronal abnormalities including swallowing esophagograms, esophageal manometry and both intrinsic and extrinsic neuronal defects are seen. videofluoroscopic evaluation of swallowing function are Also, interstitial cells of Cajal cell counts was reduced in common diagnostic methods. Esophageal motor functions esophageal examinations in EA (9). Esophageal dysmotility can be assessed by both radiological esophagograms and is also secondary to surgery and gastroesophageal reflux. esophageal manometry. The conventional diagnostic tools Extensive mobilization of esophageal pouches may cause do not correlate with the clinical symptoms, however, high- myoneuronal damage and worsen esophageal motility (10). resolution manometry (HRM) in combined with impedance Esophageal motility studies show that postoperative motor meter is highly relevant to detect symptom related motor functions were disturbed when compared with preoperative dysfunctions. Lemonie et al. described three patterns of studies. Thus, the mechanism of SD is multifactorial and disturbed motor function in children using esophageal dysphagia is an ongoing problem in patients with EA with pressure topography (EPT) in HRM according to Chicago special consequences in different periods of life. classification; aperistalsis (38%), pressurization (15%) and various types of distal contractions (47%) (16). In this study, esophageal peristalsis was affected in all children including SD related respiratory problems asymptomatic patients. These observations suggest that Respiratory problems are reported in 47% of children motor dysfunction may not be related with the symptoms. with EA (11). Structural anomalies of esophagus and Secondly, van Wijk et al. found normal peristalsis but absent trachea may also lead to aspiration and chronic respiratory distal esophageal propagation in 6 of 20 children (17). complications (12). Tracheomalacia, gastroesophageal reflux However, lower esophageal sphincter relaxation was and vocal cord paralysis are common structural problems complete in 84% of patients. in which tracheomalacia tends to be decrease with age and Videofluoroscopy (VFS) is a dynamic method is not related with lower tract respiratory infections and investigating the oral, pharyngeal and esophageal phases of © Shanghai Chest. All rights reserved. shc.amegroups.com Shanghai Chest 2017;1:42 Shanghai Chest, 2017 Page 3 of 6 Table 2 VFS scale aspiration, it has highest specificity and positive predictive VFS findings Score value when compared to VFS. Oral phase (0–3) Finally, several symptom-scoring systems have been developed to evaluate the SD in children and adults. Lip closure Dysphagia scoring (DS) system introduced by Dakkak Tongue elevation et al. includes 9 item questions regarding with the difficulty Tongue retraction in swallowing in different food consistencies (Table 4) (19). The total sum of DS was obtained by multiplying dysphagia Oral retention frequency (presence of dysphagia =1, sometimes =1/2 and Pharyngeal phase (0–3) absent =0) with the row number. The patients with DS Delay in deglutitive reflex score 0 were considered as no dysphagia, between 1–44 were Touch of root of tongue to pharynx mild dysphagia, and more than 44 were severe dysphagia. The pediatric eating assessment tool-10 (pEAT-10) is a Velopharyngeal closure validated, self-administered, symptom-specific outcome Hyopharyngeal elevation tool that is commonly used in documenting initial symptom Closure of airway severity, monitoring
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