USC School of Pharmacy

ounded in 1905, the USC School of Pharmacy is the oldest and foremost pharmacy school in Southern California. The school is a national leader known for its progressive Fcurriculum and research excellence. Approximately 50 percent of the practicing phar- macists in Southern California are graduates of USC. The school has an average student body of 730 full-time students in the Pharm.D. program, 190 students in the Master of Science, Doctor of Philosophy and Doctor of Regulatory Science programs, a full-time faculty of 71 and 390 part-time and volunteer faculty.

The school occupies state-of-the-art facilities on the USC Health Sciences campus in metropolitan Los Angeles, adjacent to the Los Angeles County+USC Medical Center (one of the largest teaching hospitals in the country), the USC/Norris Comprehensive Cancer Center, the Doheny Eye Institute and the USC University Hospital. USC pharmacy students receive clinical training at these facilities and many other affiliated hospitals, health care clinics, skilled nursing facilities, home health care agencies and pharmacies in the Southern California region. The school also owns and operates two Pharm.D. candidate Bryan Coleman consults campus pharmacies. Recognized as one of the most innovative schools of pharmacy in the nation, with a parent during Trojan Parents Weekend. The USC School of Pharmacy staffed a “For the USC School of Pharmacy serves as a model for other progressive schools. In 1950, USC was the Your Health” booth during the weekend, and first to establish the six‑year program leading to the Doctor of Pharmacy degree as the first profes- lines of parents waited for checks on osteoporosis, blood pressure, diabetes and body fat. sional degree. Additional national “firsts” that distinguish the school include: first clinical pharmacy program and first M.S. in radiopharmacy (both in 1968); first Pharm.D./M.B.A. dual degree pro- gram (1988); first M.S. and Ph.D. programs in pharmaceutical economics and policy (1994) and first professional doctorate in regulatory science (2008).

The Pharm.D. degree is complemented with additional dual/joint degree options, including Pharm.D./J.D., Pharm.D./Ph.D., Pharm.D./M.S. in regulatory science, Pharm.D./M.P.H. and Pharm.D./M.S. in gerontology. The school also offers Ph.D. and M.S. degrees in pharmaceutical ­sciences and molecular pharmacology and toxicology.

The school is a member of the American Association of Colleges of Pharmacy, which promotes the interests of pharmaceutical education. All institutions holding membership must maintain certain minimum requirements for entrance and graduation. The school is accredited by the Accreditation Council for Pharmacy Education. 824 USC School of Pharmacy

Health Sciences Campus Gavin S. Herbert Professor of Pharmaceutical Assistant Professors of Pharmacy: Betty Chan, John Stauffer Pharmaceutical Sciences Sciences: Sarah F. Hamm-Alvarez, Ph.D. Pharm.D.; Marc Cosep, Pharm.D.; Jennifer Center H. Cupo, Pharm.D.; Shetal Desai, Pharm.D.; 1985 Zonal Avenue Charles Krown/Pharmacy Alumni Professor of Emily Han, Pharm.D.; Kevin Kaneko, Los Angeles, CA 90089-9121 Pharmaceutical Sciences: Enrique Cadenas, Pharm.D.; Jiwon Kim, Pharm.D.; Kum Ja K. (323) 442-1369 M.D., Ph.D. Lee, Pharm.D.; May C. Mak, Pharm.D.; FAX: (323) 442-1681 Tien Ng, Pharm.D.; Susie Park, Pharm.D.; Office of Admission and Student Affairs Provost’s Professor of Medicine and Pharmacy: Paula Phongsamron, Pharm.D.; Veena (323) 442-1466 Michael Kahn, Ph.D. Venugopalan; Florence H. Wong-Yu, Pharm.D. Email: [email protected] Email: [email protected] Provost’s Professor of Medicine and Pharmacy: Distinguished Emeritus Professors: John A. Biles, www.usc.edu/schools/pharmacy Pat Levitt, Ph.D. Ph.D.; Paul Hochstein, Ph.D.

Administration QSAD Centurion Professor of Pharmaceutical Emeritus Professors: Glenn H. Hamor, Ph.D.; R. Pete Vanderveen, Ph.D., R.Ph., Dean Sciences: Michael B. Nichol, Ph.D. Eric J. Lien, Ph.D.

Fred G. Weissman, Pharm.D., J.D., Associate Professors: Ronald L. Alkana, Pharm.D., Programs Dean, Academic and Clinical Affairs Ph.D.; Roberta D. Brinton, Ph.D.; Gilbert The School of Pharmacy offers curricula lead- J. Burckart, Ph.D.; Enrique Cadenas, M.D., ing to the Doctor of Pharmacy (Pharm.D.) Cynthia C. White, B.A., Associate Dean, Ph.D.; Timothy M. Chan, Ph.D.; Sarah F. and Doctor of Regulatory Science (D.R.S.) Administrative Affairs Hamm-Alvarez, Ph.D.; Michael B. Nichol, degrees. Through the Graduate School, Ph.D.; Wei-Chiang Shen, Ph.D.; Jean C. graduate degrees offered are: Master of Ronald L. Alkana, Pharm.D., Ph.D., Associate Shih, Ph.D.; Rajindar Sohal, Ph.D.; R. Pete Science (M.S.) and Doctor of Philosophy Dean, Graduate Affairs and Curricular Vanderveen, Ph.D.; Walter W. Wolf, Ph.D. (Ph.D.) in pharmaceutical sciences, Master Development of Science (M.S.) and Doctor of Philosophy Associate Professors: James D. Adams, Jr., (Ph.D.) in molecular pharmacology and toxi- Enrique Cadenas, M.D., Ph.D., Associate Ph.D.; Julio A. Camarero, Ph.D.; Jason N. cology, Master of Science (M.S.) and Doctor Dean, Research Affairs Doctor, Ph. D.; Roger F. Duncan, Ph.D.; Ian of Philosophy (Ph.D.) in pharmaceutical S. Haworth, Ph.D.; Joel W. Hay, Ph.D.; Jeffrey economics and policy, and Master of Science Sarah F. Hamm-Alvarez, Ph.D., Chair, S. McCombs, Ph.D.; Nouri Neamati, Ph.D.; (M.S.) in regulatory science. Five dual degree Department of Pharmacology and Pharmaceutical Curtis T. Okamoto, Ph.D. programs, one joint program and numer- Sciences ous certificate programs are also offered: Assistant Professors: Jeonghoon Ahn, Ph.D.; Pharm.D./J.D., Pharm.D./M.B.A., Pharm.D./ Kathleen A. Johnson, Pharm.D., M.P.H., Bangyan Stiles, Ph.D.; Clay C.C. Wang, Ph.D. M.P.H., Pharm.D./M.S. in regulatory science, Ph.D, Chair, Titus Family Department Pharm.D./M.S. in gerontology, Pharm.D./ of Clinical Pharmacy and Pharmaceutical Lecturer: Rebecca Romero, Ph.D. Ph.D., Pharm.D./graduate certificate in ger- Economics & Policy ontology, certificate in clinical research design Research Associate Professors: Kevin J.Y.H. Shin and management, certificate in food safety, Faculty Chen, Ph.D.; J. Andrew MacKau, Ph.D. certificate in preclinical drug development, John Stauffer Dean’s Chair in Pharmaceutical and certificate in patient and product safety. Sciences: R. Pete Vanderveen, Ph.D., R.Ph. Research Assistant Professors: Julianna Hwang, Pharm.D.; Vera Pravica, M.D., Ph.D.; Igor The USC School of Pharmacy is accredited University Professor and Boyd P. and Elsie D. Rebrin, Ph.D.; Liquin Zhao, Ph.D. by the Accreditation Council for Pharmacy Welin Professor of Pharmaceutical Sciences: Jean Education, 20 North Clark Street, Suite 2500, Chen Shih, Ph.D. Professors of Pharmacy: Ian Hutchinson, Ph.D., Chicago, IL 60602, Phone: (312) 664-3575, D.Sc.; Frances Richmond, Ph.D.; Glen L. FAX (312) 664-4652. Distinguished Professor: Walter Wolf, Ph.D. Stimmel, Pharm.D.; Bradley R. Williams, Pharm.D. Tuition and Fees (Estimated) William A. Heeres and Josephine A. Heeres Tuition for School of Pharmacy degree Endowed Chair in Community Pharmacy: Associate Professors of Pharmacy: Melvin F. ­programs (Pharm.D.; M.S. and Ph.D. in Kathleen A. Johnson, Pharm.D., M.P.H., Ph.D. Baron, Pharm.D., M.P.A.; Paul M. Beringer, ­pharmaceutical sciences; M.S. and Ph.D. Pharm.D.; Kathleen H. Besinque, Pharm.D., in molecular pharmacology and toxicology; Hygeia Centennial Chair in Clinical Pharmacy: M.S.Ed.; Steven Chen, Pharm.D.; Alfred M.S. and Ph.D. in pharmaceutical economics Gilbert J. Burckart, Ph.D. Chin, Pharm.D.; Daryl L. Davies, Ph.D.; and policy) is charged at the following rate Julie A. Dopheide, Pharm.D.; Kevin L. (which differs from standard USC tuition): R. Pete Vanderveen Chair in Therapeutic Discovery Forrester, Pharm.D.; Jeffery Goad, Pharm.D., per semester (15-18 units) $19,819; for less and Development: Roberta Diaz Brinton, Ph.D. M.P.H.; William C. Gong, Pharm.D.; Kathleen than 15 units and each unit above 18 units, A. Johnson, Pharm.D., M.P.H., Ph.D.; Jack $1,321 per unit. See the Tuition and Fees John A. Biles Professor of Pharmaceutical W. Kern, Pharm.D.; Cynthia L.L. Lieu, section, page 39, for fee information. These Sciences: Wei-Chiang Shen, Ph.D. Pharm.D.; Stanley G. Louie, Pharm.D.; fees are based upon current information Gladys H. Mitani, Pharm.D.; Irving Steinberg, available at the time of publication and are Timothy M. Chan Professor of Complementary Pharm.D.; Gregory A. Thompson, Pharm.D.; subject to possible later change. Therapeutics: Rajindar S. Sohal, Ph.D. Fred G. Weissman, Pharm.D., J.D.; Michael Z. Wincor, Pharm.D.; Annie Wong-Beringer, Pharm.D.; Frances S. Wong, Pharm.D. Professional Degrees 825

Doctor of Pharmacy students must pay a Phi Lambda Sigma Student Health Services, Health Sciences $500 non-refundable acceptance deposit The Phi Lambda Sigma chapter was estab- Campus that is applicable toward tuition. For deposit lished at USC in 1988. This national pharmacy Services of the Student Health Center, cov- information in other degree programs in the leadership society is devoted to identifying, ered by the mandatory student health fee, School of Pharmacy, please consult appropri- supporting and recognizing the contribution include the usual ambulatory care health ate offices. of pharmacy students to their colleges, their services given by the faculty of the USC classmates, their campuses, their communi- Department of Family Medicine and the Honor Societies ties and to their chosen profession. Student Health Center nursing staff. Hours Rho Chi are from 8:30 a.m. to 4:30 p.m., Monday Theta chapter of Rho Chi, national honor- Student Housing and Service Facility, through Friday, excluding USC holidays. The ary pharmaceutical society, was established Health Sciences Campus Student Health Center is located in the USC at USC in 1925. Charters for chapters of There are limited university-managed accom- Health Care Consultation Center, 1500 San this organization are granted only to student modations on the Health Sciences campus. Pablo Street, Suite 104, adjacent to the USC groups in those colleges that are members in Students may wish to live in student hous- University Hospital, one block northeast of good standing of the American Association of ing on the University Park campus, located the School of Pharmacy. The telephone num- Colleges of Pharmacy. Eligibility for member- about eight miles from the Health Sciences ber is (323) 442-5980. In addition to the stu- ship is based on high attainment in scholar- campus. dent health fee, all Pharm.D. students must ship, character, personality and leadership. have major medical insurance coverage from All candidates selected for membership must The Blanche and Frank R. Seaver Student the USC Health Plan. A student may request have completed two years of college work, Residence, adjacent to the John Stauffer a waiver of the USC Health Plan if covered and they must be approved by the Dean of Pharmaceutical Sciences Center, provides by a personal medical plan acceptable to the the School of Pharmacy. dining facilities and a book store. For resi- Health Insurance Office. dence information, phone (323) 442-1576; for bookstore information call (323) 442-2674.

Professional Degrees

Doctor of Pharmacy

A four-year curriculum, following appropri- All documents mailed directly to the School Admission of International Students ate college prerequisite work, leading to the of Pharmacy and received from PharmCAS International students may be admitted on Doctor of Pharmacy (Pharm.D.) is offered to by the Office of Admission become the a space available basis. All requirements students admitted to the School of Pharmacy. ­property of the university and cannot be described in this section are also applicable A sample outline of the curriculum is listed returned or duplicated for other than univer- to the admission of international students. In in the following pages. The degree will be sity purposes. addition, special application and admission conferred when the student has successfully procedures are required of international stu- completed all Doctor of Pharmacy degree Admission Guidelines dents. Refer to the section on Admission of requirements. The Admission Committee considers sev- International Students in this catalogue. eral factors in making admissions decisions: Application Procedure strong academics; competitive performance Entrance Requirements The School of Pharmacy uses the Pharmacy in the interview; recommendation forms; Admission to the School of Pharmacy requires College Application Service (PharmCAS) and written comments specified in the completion of a baccalaureate degree, com­ and a supplemental application for its admis- application. The committee also considers a pletion of the prerequisite college courses, sion process. Applications are available at candidate’s motivation to pursue pharmacy, a minimum 3.0 (A = 4.0) cumulative grade www.usc.edu/schools/pharmacy. The PharmCAS strong interpersonal skills, excellent oral and point average and a minimum 3.0 grade point and supplemental application deadline is written communication skills, and leader- average in the prepharmacy prerequisites. November 1. ship abilities. While the School of Pharmacy gives equal consideration to every qualified Applications received before November 1 applicant, the school cannot accommo- will have priority interview consideration date all qualified candidates who apply for when the PharmCAS and supplemental admission. application are submitted and all necessary criteria have been met. Follow the instruc- tions carefully for the PharmCAS application and the supplemental application for the USC School of Pharmacy. Both applications must be received by the Office of Admission and Student Affairs before the evaluation process can begin. 826 USC School of Pharmacy

Prepharmacy Requirements Biological Sciences taken at the college/university level. AP/IB To be eligible for admission to the School of General biology: a one-year course (two courses used to meet prerequisites will be for Pharmacy, students must take the required semesters, three quarters) for science majors course credit only (i.e., they will not count prerequisite college courses, including gen- is required in general biology with laboratory toward the GPA). The Admission Committee eral chemistry, organic chemistry, general (excluding courses in human anatomy, human recommends that applicants enroll in all of biology, physics, biochemistry, molecular physiology, botany and microbiology). If the the required pre-pharmacy courses. Please biology or cell biology, microbiology, mam- school offers less than a one-year course, contact the School of Pharmacy Office of malian physiology, calculus, statistics, a social the student must complete the second Admission for specific information. sciences course related to human behavior, semester at another institution. The recom- and a course in microeconomics. These sci- mended courses at USC are BISC 120Lx and Entrance Examination ence requirements should be completed at BISC 220L. An in-person interview is required for admis- any accredited four-year university. All other sion. The PCAT is not required. requirements may be completed at a two-year Microbiology (with lab): one course in fun- college. damental microbiology for science majors, Transfer Students including laboratory, is required. A one- Transfer students from other U.S. accredited Grades of pass/no pass or credit/no credit ­quarter course may require a separate labora- colleges of pharmacy are accepted into the will not be accepted (unless a course is only tory course. The recommended course at Pharm.D. program on a space available basis. offered on a pass/no pass basis). USC is BISC 300L. Post-Baccalaureate Program Please note: One semester hour requires two Molecular or cell biology: one upper division The School of Pharmacy accepts a limited quarter hours. course in molecular or cell biology for science number of applicants (if vacancies exist) majors is required. The recommended course who hold a recently conferred baccalaureate Mathematics and Physical Sciences at USC is BISC 320L or BISC 411. degree in pharmacy from a college of phar- Courses must include calculus, statistics, macy accredited by the Accreditation Council general chemistry, organic chemistry and Biochemistry: one upper division course in for Pharmacy Education. Such applicants physics. Only courses for science majors are biochemistry for science majors is required. may not be required to meet all prepharmacy acceptable. It is highly recommended that The recommended course at USC is requirements in order to qualify for admission math and science courses be completed dur- BISC 330L. and, if admitted to the Doctor of Pharmacy ing the regular academic year and not during program, may be accepted at an advanced a summer term. Mammalian physiology: one course in mam- level for a minimum of two years (72 semester malian physiology for science majors is units) of full-time study. Calculus: one semester or two quarters of cal- required (human physiology is preferred; culus are required. The course should include courses in plant physiology, cell physiology Special Admissions Program for Entering differential and integral calculus for science and marine physiology cannot be used to Freshmen and USC Undergraduates majors. The recommended course at USC is meet this requirement). The recommended The Trojan Admission Prepharmacy (TAP) MATH 125. course at USC is BISC 307L. program provides guaranteed admission to the USC School of Pharmacy for USC undergrad- Statistics: One course in statistics (not business Social and Behavioral Sciences uates who meet preset performance standards. statistics) is required. One course in human behavior (psychology, The TAP program is designed to attract highly sociology, cultural anthropology or related qualified, mature high school seniors apply- General chemistry: a one-year course for sci- courses is required). ing to USC. Admission requirements for high ence majors, including laboratory, is required. school applicants to the TAP program include The course should include inorganic chemistry Economics: one course in microeconomics is prior admission to any USC undergraduate and qualitative analysis. The recommended required. If a one-year course is offered, both program. Currently enrolled USC undergradu- courses at USC are CHEM 105aLbL. semesters may be taken and excess units may ates may apply to the TAP program with a be applied to either the remainder of the unit 3.2 GPA at USC. Transfer students are eligible Organic chemistry: a one-year course for sci- requirements for the subject area or as elec- for the TAP program provided they study at ence majors, including laboratory, is required. tive units. The equivalent course at USC is USC for a minimum of two years. A bachelor’s If the school offers less than a one-year ECON 203. degree from USC is required for all TAP stu- course, the student must complete the second dents beginning fall 2009. semester at another institution. The recom- Students who have earned a baccalaureate mended courses at USC are CHEM 322abL. degree and meet the prerequisites described Students accepted into the TAP program above (including general psychology or intro- must meet all Pharm.D. entrance require- Physics: a one-semester (two quarters) course duction to sociology and microeconomics or ments, prerequisites, take a full course load in physics for science majors with laboratory macroeconomics) at the time of admission will each semester, complete their pre­pharmacy is required (inclusion of thermodynamics and have fulfilled the requirement for social and requirements with at least a 3.2 cumulative electromagnetism is recommended). The rec- behavioral sciences. GPA and have a minimum 3.0 cumulative ommended courses at USC are PHYS 135abL GPA. All prepharmacy courses must be taken or PHYS 151L and PHYS 152L. Advanced Placement and International for letter grades. Pass/no pass, credit/no Baccalaureate Examinations credit grades and grades lower than C are not Applicants can use AP and IB courses to acceptable. meet USC School of Pharmacy prerequisites with the following provisos. AP results are acceptable with scores of 4 or 5. IB results are acceptable with a score of 5. Science courses must include respective laboratory courses Professional Degrees 827

TAP program participants who fulfill the Program of Courses Year III students must choose their electives requirements listed above will be guaranteed year I, Fall (18 units) units from the following (3 units each): admission to the Doctor of Pharmacy pro- PHRD 501 Pharmaceutics I 4 PHRD 651 Community Pharmacy I gram at USC. TAP program students receive PHRD 503 Biological Systems I 4 PHRD 652 Community Pharmacy II ongoing individual advisement, access to the PHRD 507 Health Care Delivery PHRD 653 Health Systems Pharmacy I School of Pharmacy’s student services and the Systems 2 PHRD 654 Health Systems Pharmacy II privilege of joining the student-run prephar- PHRD 509 Pharmacy Practice PHRD 655 Geriatric Pharmacy I macy club, the USC Pre-Pharmacy Society. and Experience I 4 PHRD 656 Geriatric Pharmacy II A specific listing of USC courses and a recom- PHRD 555 Biochemical and Molecular PHRD 657L Basic Research Design mended program for TAP participants can be Sites of Drug Action 4 PHRD 658 Sleep and the Pharmacologic obtained from the School of Pharmacy Office Management of Its Disorders of Admission or online at www.usc.edu/schools/ year I, Spring (18 units) units PHRD 659 Molecular Therapeutics: pharmacy/pharmd/programs/tap.html. PHRD 502 Pharmaceutics II 3 Signal Transduction PHRD 504 Biological Systems II 6 PHRD 660 Disease State Management I General Education Requirements (TAP Students PHRD 505 Molecular Genetics PHRD 661 Pharmacy Practice in Only) and Therapy 3 Women’s Health TAP students must meet the university’s PHRD 510 Pharmacy Practice PHRD 662 Psychiatric Pharmacy general education requirements; see pages 60 and Experience II 4 Practice and 245 for details. PHRD 554 Public Health and PHRD 663 Pharmaceutical Development Epidemiology 2 PHRD 664 Clinical Problem Solving Pharm.D. Curriculum Requirements PHRD 665 Complementary/Alternative The completion of a four-year professional year II, Fall (18 units) units Therapeutics curriculum is required to earn the Doctor of PHRD 506 Self Care and Non- PHRD 666 Therapeutic Drug Pharmacy degree. The curriculum, except for Prescription Therapies 5 Monitoring the fourth year, is a “block” program. All stu- PHRD 508 Pharmacy Literature PHRD 667 Drugs of Abuse dents must enroll in 18 units each semester Analysis and Drug PHRD 668 Computing Application in courses designated for the fall or spring. Information, or PHRD 669 Health Care Needs of Students do not have choices of courses to PHRD 561 Parenteral Therapy Special Populations take nor are they permitted to drop any one Externship 3 PHRD 670 Marketing and Development course or courses during the semester. (Year PHRD 551 Immunology 3 in the Pharmaceutical III and IV students have elective course PHRD 557 Therapeutics I 5 Industry choices). Progress is permitted only when the PHRD 559 Therapeutics II 2 PHRD 677 Risk Assessment and prior semester is completed in full. Students Management in Pharmacy should view the curriculum outlined here as year II, Spring (18 units) units Practice advisory only and subject to modification. PHRD 552 Pharmaceutics III 3 Aggregate hours must equal a minimum of PHRD 553 Management within year IV, Fall (18 units) 144 units to meet graduation requirements. Health Care Organizations 2 Required Clerkships PHRD 560 Therapeutics III 6 Elective Clerkships The pharmacist of tomorrow will provide PHRD 561 Parenteral Therapy preventive and therapeutic pharmaceutical Externship, or year IV, Spring (18 units) care, provide drugs to patients, communicate PHRD 508 Pharmacy Literature Required Clerkships in health care matters, meet the ethical and Analysis and Drug Elective Clerkships legal requirements of the practice of phar- Information 3 macy and maintain professional expertise. PHRD 562 Therapeutics IV 4 The curriculum committee of the School Required Clerkships (6 units each) — four of Pharmacy has developed guidelines and year III, Fall (18 units) units rotations: patient care competencies consistent with PHRD 601 Therapeutics V 6 PHRD 701 Acute Care Clinical Practice interpretations of this new role. An appro- PHRD 603 Therapeutics VI 3 Clerkship priate and dynamic educational program is PHRD 605 Therapeutics VII 4 PHRD 705 Community Pharmacy needed to develop these competencies, and PHRD 607 Nutrition 2 Clerkship curriculum changes are necessary and desir- Elective 3 PHRD 704 Primary Care Clerkship, or able in order to meet scientific advances, PHRD 718 Hospital Pharmacy Practice population profile changes, increasing health year III, Spring (18 units) units Clerkship expectations, technological advances, the PHRD 606 Therapeutics VIII 2 increasing role of the government in health PHRD 608 Therapeutics IX 2 An inpatient practice elective must be satisfied services and other influences. PHRD 610 Therapeutics X 3 by PHRD 702 if the student selects PHRD 707 PHRD 612 Therapeutics XI 2 Outpatient Psychiatric Pharmacy Clerkship. If PHRD 614 Pharmaceutical Economics the student selects PHRD 702, the student may and Outcome Studies 3 take elective clerkships marked * to satisfy the PHRD 616 Pharmacy Law and Ethics 3 requirement. Elective 3 828 USC School of Pharmacy

Elective Clerkships — two rotations (limit PHRD 728 Directed Clinical Project Degree Requirements of one course that does not involve direct Clerkship III All students in the Doctor of Pharmacy patient care): PHRD 729 Directed Clinical Project degree program must meet course require- PHRD 702* Inpatient Psychiatric Clerkship IV ments, grade point average requirements and Pharmacy Clerkship PHRD 730 Acute Care Geriatrics program residency requirements. All course PHRD 703 Long Term Care Clerkship Clerkship requirements must be completed with a PHRD 706 Geriatrics Clerkship PHRD 731 Advanced Geriatrics grade of “C” or better. The degree will not PHRD 707 Outpatient Psychiatric Clerkship be conferred until the student has successful- Clerkship PHRD 732* Pharmacy Administration ly completed all Doctor of Pharmacy degree PHRD 708* Inpatient Clinical Practice Clerkship requirements. Students are subject to the Clerkship PHRD 733* Anticoagulation Therapy degree requirements in the USC Catalogue PHRD 709* Pediatric Drug Therapy Clerkship current for the semester of their admis- Clerkship PHRD 734* Antimicrobial Therapy sion into the Doctor of Pharmacy program. PHRD 710* Surgery Clerkship Clerkship Students must have a cumulative grade point PHRD 711* Cardiovascular Drug Therapy PHRD 735* Clinical Pharmacy Research average of 3.0 in the Pharm.D. curriculum to Clerkship Clerkship meet graduation requirements. PHRD 712* Applied Clinical PHRD 736* Chemical Dependency Pharmacokinetics Clerkship Clerkship Registration PHRD 713* Drug Information Clerkship PHRD 737* Clinical Transplantation Details of the School of Pharmacy registration PHRD 714* Radiopharmacy Clerkship Clerkship procedure will be included in the orientation PHRD 715* Oncology Clerkship PHRD 738* Pharmaceutical Industry program prior to the first week of classes. PHRD 716* Ob-Gyn Clerkship Clerkship PHRD 717 Dermatology Clerkship PHRD 739 AIDS/Immune Disorders Cancellation of Registration PHRD 719 Pain Management Clerkship Clerkship During the first three years of the Doctor PHRD 720* Critical Care Clerkship PHRD 740* Health Care Systems of Pharmacy program (Years I, II and III), a PHRD 721* Drug Utilization and Administration Clerkship student will only be permitted to withdraw Evaluation Clerkship PHRD 741 Advanced Ambulatory Care from all courses enrolled in a semester and PHRD 722 Home Health Care Clerkship Clerkship may not selectively withdraw from a single PHRD 723* Nutritional Support Clerkship course or group of courses. During the fourth PHRD 724 Advanced Community *Indicates course does not involve direct patient care. year, students must contact the School of Pharmacy Clerkship Pharmacy Office of Admission and Student PHRD 725* International Pharmacy Total for Pharm.D. degree: 144 semester Affairs for withdrawal guidelines. Procedures Clerkship units. for readmission into the program or make- PHRD 726* Directed Clinical Project up of incomplete courses and clerkships are Clerkship I included in the school’s brochure on academ- PHRD 727 Directed Clinical Project ic policies and procedures. Clerkship II

Graduate Degrees

The School of Pharmacy, through the submitted to: Graduate Programs Office, USC following disciplines: mathematics, organic Graduate School, offers curricula leading to School of Pharmacy, 1985 Zonal Avenue, Los chemistry, physical chemistry, biochemistry, the M.S. and Ph.D. degrees in pharmaceuti- Angeles, CA 90033. Additional information physiology and pharmacology. In addition to cal sciences and in molecular pharmacology may be obtained by calling (323) 442-1474 or the application for admission, three letters of and toxicology. The school also offers an sending email to [email protected]. recommendation from faculty members who interdisciplinary M.S. in regulatory science. can evaluate the promise of the applicant The Ph.D. degree in pharmaceutical eco- Admission Requirements for the Master for graduate study and a personal statement nomics and policy is offered jointly with of Science and Doctor of Philosophy in summarizing career objectives and research the Department of Economics. The M.S. Pharmaceutical Sciences interests must be submitted. degree in pharmaceutical economics and Applicants should possess a bachelor’s degree policy is offered jointly with the School of or equivalent from an accredited college or Applicants who do not meet all the specific Policy, Planning, and Development and the university. A minimum grade point average requirements indicated above, but who Department of Economics. In addition, the of 3.0 and qualifying scores on the GRE in show unique potential, may be considered school offers dual degrees with the schools the verbal and quantitative tests are required. for admission with conditions which may be of law, business and gerontology as well as In addition to excellent communication fulfilled during the first semester of enroll- other programs. Instructions given in the skills, applicants should possess knowledge ment. See the Graduate School section of this Admission section of this catalogue are to be and competence equivalent to one year of catalogue, page 93. followed, but the application and the supple- acceptable course work in at least three of the mental information requested should first be Graduate Degrees 829

Admission Requirements for the Master Admission Requirements for the Master of Admission Requirements for the Master of of Science and Doctor of Philosophy in Science in Pharmaceutical Economics and Science in Regulatory Science Molecular Pharmacology and Toxicology Policy Applicants should possess a bachelor’s degree Applicants should possess a bachelor’s degree Applicants for admission must have achieved or equivalent from an accredited college or equivalent from an accredited college or a minimum 3.0 GPA in undergraduate or or university. Applicants with graduate or university. A minimum grade point average professional school and adequate scores on professional degrees are encouraged to apply. of 3.0 and qualifying scores on the GRE in the GRE. In addition, applicants will be A minimum grade point average of 3.0 or verbal and quantitative tests are required. In required to have completed upper division qualifying scores on the GRE or equivalent addition to excellent communication skills, courses in statistical methods, calculus and examination are required. The program applicants should possess knowledge and microeconomics. encourages the participation of part-time competence equivalent to one year of work ­students with work experience. in at least three of the following disciplines: Admission Requirements for the Doctor of mathematics, organic chemistry, physical Philosophy in Pharmaceutical Economics Acceptance criteria for those individuals will chemistry, biochemistry, molecular biol- and Policy be assessed on a case-by-case basis. English ogy, cell biology, physiology, pharmacology, Candidates with a bachelor’s, master’s proficiency is essential. Students will be economics, statistics and computer sciences. or Pharm.D. degree are invited to apply. selected for admission, whenever possible, In addition to the application for admission, Applicants must have demonstrated pro- after interviews with one or more members the candidate must submit three letters of ficiency in verbal and written English and of faculty. recommendation from faculty members who aptitude in economics, mathematics, statis- can evaluate the promise of the applicant tics and computer science. Deficiencies in Admission of International Students to for graduate study and a personal statement economics and statistical background can be Graduate Degree Programs summarizing the candidate’s career objec- addressed through preliminary course work All requirements described in this section are tives and research interests. Students will be after admission to the program. also applicable to the admission of interna- selected for admission on the basis of their tional students. In addition, special applica- academic and scientific record, and, whenever A minimum grade point average of at least tion and admission procedures are required possible, interviews (in person or by phone) 3.0 (A = 4.0) is required. Special attention is of international students. Refer to the section with one or more members of the faculty. given to the grades achieved in economics, on Admission of International Students in statistics and mathematics courses relevant to this catalogue. the program. A qualifying score on the GRE in verbal and quantitative areas is required. Students with GRE scores of 1200 or better will be given priority for financial aid support.

Degree Requirements

These degrees are under the jurisdiction of Master of Science in Pharmaceutical Students must complete all requirements for the Graduate School. Students should also Economics and Policy the degree within five years of entry into refer to the Requirements for Graduation The Department of Pharmaceutical the program. section, page 58 and the Graduate School Economics and Policy (School of Pharmacy) section of this catalogue for general regula- offers a program of study leading to the Additional Degree Requirements tions, page 93. All courses applied toward M.S. degree. Applicants must apply to the The student must satisfactorily complete the the degrees must be courses accepted by the Graduate School and meet the admissions specified courses in economics, preventive Graduate School. requirements of the program. This program medicine and public administration prior requires students to demonstrate skills in the to enrolling in PMEP 538 or PMEP 539. Master of Science in Pharmaceutical analysis of pharmaceutical and health tech- The student is also required to complete an Sciences nology innovations, as well as an understand- empirical research project on a topic relevant A Master of Science in the pharmaceutical ing of contemporary health policy issues. to pharmaceutical economics and policy. sciences will be granted on the basis of com- A minimum of 36 units of graduate level pletion of at least 24 units of formal course courses is required. Master of Science in Regulatory Science work and presentation of an acceptable thesis Regulatory science relates the regulatory and (PSCI 594ab, 4 units) based on the results of Grade Point Average legal requirements of biomedical product an original investigation. A grade point average of at least 3.0 (A = 4.0) development to the scientific study needed must be achieved on graduate course work to establish product safety and efficacy. Master of Science in Molecular at USC. A Master of Science degree in regulatory Pharmacology and Toxicology science will be granted upon completion of A Master of Science in molecular pharma­ Course Requirements at least 30 units of formal course work and cology and toxicology will be granted on the The student is required to complete the fol- 6 units of research project work in an intern- basis of completion of 32 units: 24 units of lowing 36 units of graduate level course work: ship setting (MPTX 630). Students with formal course work, MPTX 594ab (4 units ECON 414 (4 units), ECON 500 (4 units) experience in industry or government can over two semesters), MPTX 700 (4 units or PPD 501 (4 units), PM 511aL (4 units), substitute an equivalent amount of formal over four semesters) and a presentation of an PM 512 (4 units) or approved elective, course work for the research project with the acceptable thesis based on the results of an PMEP 509 (4 units), PMEP 519 (4 units), permission of the admissions committee. original investigation. PMEP 529 (4 units), PMEP 538 (4 units) and PMEP 539 (4 units). 830 USC School of Pharmacy

Course requirements normally include a normal rules of the university. Students who Product Lifecycle Strategy minimum of three courses concerned with have graduated from the M.S. program in Eight or more units of course work related regulatory aspects of medical product devel- Regulatory Science can apply all of the previ- to product lifecycle management, from opment and a minimum of one course each ously taken course work toward the doctoral discovery to commercialization, will be in quality assurance, clinical research, busi- degree. Students with graduate degrees from drawn from a broad list of courses offered ness, statistics and law. Recommended course outside of the regulatory science program in regulatory science or through the Titus work includes some courses available in are required to take a minimum of 32 units Family Department of Clinical Pharmacy other departments of the university. Students of course work and 4 units of dissertation and Pharmaceutical Economics and should develop a specific plan of study in research to complete the requirements for Policy. Included in this list are: PMEP 538 consultation with the graduate advisors graduation. The course work requirements Pharmaceutical Economics; PMEP 539 before beginning the program. will be determined on an individual basis in Economic Assessment of Medical Care; consultation with the program director and RSCI 601 Biomedical Commerce. Other Doctor of Regulatory Science participant’s advisors. courses may also be considered in consulta- The Doctor of Regulatory Science program tion with the supervisors and program direc- cultivates research, leadership and inquiry Curriculum Requirements tor. Students are also encouraged to take skills for advanced students in the emerging The Doctor of Regulatory Science is admin- courses outside the School of Pharmacy when profession of global regulatory science. It is istered by the School of Pharmacy. It requires more specialized courses fit their professional designed to produce graduates with expertise participants to complete 64 units that include research or development plans. in strategic management, policy development the following elements: and research assessment who can play leader- Global Regulatory Strategy and Policy ship roles in the public sector, academia and REQUIREMENTS UNITS Eight or more units of course work related to the medical products industry. Participants Foundation courses 15 global regulatory strategy could include some in this program will take a set of interdepen- Product lifecycle strategy 8 of the following courses: MPTX 519 Global dent courses that extend from a strong core Global strategy 8 Regulation of Medical Products; PPD 571 of basic regulatory science course work and Project/personnel management 8 International Public Policy and Management additionally focus on three main areas — Research methods 4 Seminar; RSCI 604 Regulatory Strategy global product strategy, product lifecycle Dissertation 4 in Asia; RSCI 608 Regulatory Strategy in strategy, and project and personnel manage- Europe and the Americas. ment. After students have completed foun- Additional elective course work will be dational course work, they will participate as selected in consultation with the program Project and Personnel Management a cohort that typically has a two-year cycle of advisors according to the areas of intended Eight or more units of relevant course work classes and an additional year of dissertation specialization of the participant in order to should typically include: MPTX 602 Science, research. The program has been designed meet the credit requirements of the pro- Research and Ethics; RSCI 603 Managing to meet the needs of individuals who are gram. Typically foundational courses and Complex Projects; RSCI 605 Managing already working full-time outside of the uni- some electives will be taken in the first two Organizations and Human Resources. versity. The doctoral degree will be adminis- years of the program. Advanced courses in Graduate courses in other university depart- tered by the School of Pharmacy. product lifecycle strategy, global strategy and ments or schools can be substituted with the project/personnel management will normally approval of the program director. Admission be taken by the doctoral cohort of students The program is designed for individuals with during the third and fourth years of the Research Methods strong professional experience and demon- program. Dissertation planning and research Participants will typically take PMEP 509 strated intellectual and leadership capabili- will typically commence in the third year of Research Design or MPTX 522 Introduction ties. Applicants are expected to have a GPA the program, and extend until the successful to Clinical Design and Statistics. of 3.0 on university-level course work and completion of the dissertation. five or more years of professional experience. Student Progress and Assessments Admission requirements include university Foundation Courses In the third year, students are expected to transcripts, a resume, at least three letters of Fifteen or more units of foundation courses identify a pair of advisors including one reference, and a one-page personal statement may be taken as part of the master’s program USC faculty member and one advisor from that outlines the background and goals of in regulatory science, or with prior approval, industry or the private sector. Students are the applicant. Students are encouraged even from another graduate program with similar typically placed in study groups of three or at this early stage to identify areas in which objectives. Required foundational courses four whose dissertation interests are most they are interested in conducting research. normally include: MPTX 511 Introduction similar and whose collective supervisors will Additional requirements for international stu- to Medical Product Regulation; two from oversee their academic and research progress. dents are outlined by university regulations MPTX 512 Regulation of Pharmaceutical This committee will form the dissertation under Admission of International Students, and Biological Products, MPTX 513 Regula­ committee. page 79. Students are not required to provide tion of Medical Devices and Diagnostics, GRE scores unless indicated by the program MPTX 514 Regulation of Food and Dietary At the completion of the foundational course director. Supplements; MPTX 515 Quality Systems work, students will undergo a competency and Standards; MPTX 516 Medical Products review that will include considerations of Students with an appropriate graduate or and the Law; MPTX 517 Structure and academic progress. Students are expected to professional degree may use some previous Management of Clinical Trials. Other courses maintain a GPA of 3.0 and will be required to graduate courses as transfer units toward the may be substituted after the participant’s pass a written examination designed to assure overall credit requirements of the Doctor of background preparation has been considered. the professional competence of the student Regulatory Science program with the approv- prior to advancing further in the program. al of the program director and under the Graduate Degrees 831

Students who do not pass this preliminary be from outside the department granting the mechanisms of action. Research opportunities review, administered prior to entering the degree. The student should select a graduate span investigations of fundamental molecu- dissertation and advanced course work phase advisor and guidance committee no later than lar and cellular physiological mechanisms, of the program, will be notified of dismissal the third semester in residence. including receptor activity, intracellular from the program in writing by the associate signaling and the regulation of gene expres- dean for graduate studies in the School of Screening Procedure sion, to the molecular bases of disease and Pharmacy. The performance of each student will be aging, including avenues of pharmacological evaluated no later than the end of the sec- intervention. Doctoral Dissertation ond semester of enrollment in the graduate Students must enroll in RSCI 794 Doctoral program. This screening procedure is con- A minimum of 60 units is required. At least Dissertation for at least two terms, during ducted by the student’s guidance committee 24 units of course work are required at the which time they will develop a dissertation or, if a student has not selected his or her 500-level or above, exclusive of seminars and proposal and conduct the necessary research research advisor at that time, by the Graduate directed research. The guidance committee and analysis in collaboration with the super- Review Committee of the department. The may require more than 24 units of course visory team. The dissertation committee committee reviews thoroughly the student’s work in some cases. The specific require- will approve the thesis plan and monitor its progress up to that point in various areas ments will depend on the student’s back- progress. Each student will be required to including course work, research interests ground and research area and will be deter- produce and defend an independent disserta- and laboratory performance on his or her mined by the student’s advisor and advisory tion as a requirement for graduation. A maxi- research project or laboratory rotations. If a committee. A minimum of 12 units is to be mum of 6 dissertation units can be applied to performance deficiency is detected at that taken in appropriate courses offered by the satisfy the degree requirement, but students point by the committee, the student will School of Pharmacy. The remaining 36 units should register for the dissertation units in be recommended to either take additional may be fulfilled with other courses, directed each term subsequent to the completion of course work or transfer to the Master of research and dissertation. A maximum of their course work requirements. Institutional Science program. Passing this screening pro- 12 units can be transferred from graduate Review Board approval is required for all cedure is prerequisite to continuation in the studies elsewhere. human studies. Ph.D. program. Foreign Language Requirement Doctor of Philosophy in Pharmaceutical Qualifying Examination There is no formal language requirement. Sciences Students will be required to pass a compre- However, an individual guidance committee This program emphasizes basic as well hensive qualifying examination in major areas can require competency in a foreign language as applied research in drug delivery and of the pharmaceutical sciences. The examina- or a computer language if it is relevant for the targeting, utilizing medicinal chemistry, tion is administered by the guidance commit- student’s area of research. computational chemistry, pharmaceutics, tee and consists of two parts: a written exami- pharmaco­dynamics, molecular pharmacol- nation and a written proposition outlining a Guidance Committee ogy, immunol­ogy and cell biology. research project, followed by an oral examina- Upon admission, the student will be assigned tion based on the proposition and questions to a member of the graduate faculty who will A minimum of 60 units is required for the dealing with the written examination. serve as his or her temporary advisor until a Doctor of Philosophy degree. At least 24 units permanent advisor has been identified. The of course work are required at the 500-level All course and qualifying examination student’s program of study will be under the or above, exclusive of seminar and directed requirements for the Doctor of Philosophy direction of a guidance committee composed research. The guidance committee may must be completed within two and one half of at least five members, one of whom must require more than 24 units of course work. years after admission. be from outside the department. The student A minimum of 12 units is to be taken in should select a graduate advisor and guidance courses in the Department of Pharmaceutical Dissertation committee no later than the third semester Sciences and a minimum of 8 units must be A dissertation based on original investigation is in residence. The graduate affairs committee taken in various related disciplines outside required. The research should make a contri- will serve as the guidance committee until the department. The remaining 36 units bution to science and should demonstrate the one is selected. may be fulfilled with other courses, directed candidate’s scholarly advancement and com- research and dissertation. petence to undertake independent research. Screening Procedure An oral defense of the dissertation will be held The performance of each student will be Foreign Language Requirement after the candidate submits the final draft of evaluated no later than the end of the second There is no formal foreign language require- the dissertation to the dissertation committee semester of enrollment in the graduate pro- ment. However, an individual guidance com- (see Theses and Dissertations, page 96). gram. This screening procedure is conducted mittee can require competency in a foreign by the student’s guidance committee or, if language or some other research tool such as Student Teaching a student has not yet selected a guidance computer language, if this is relevant for the Teaching experience is considered an inte- committee, by the graduate affairs commit- student’s area of research. gral part of the training of graduate students. tee. The committee reviews the student’s Thus, as part of the general requirements progress to date in various areas including Guidance Committee for the Ph.D., each student is required to course work, research interests and laboratory Upon admission, the student will be assigned participate in the teaching program of the performance on his or her research project to a member of the graduate faculty who will School of Pharmacy. or laboratory rotations. If a performance serve as his or her temporary advisor until a deficiency is determined, specific goals will permanent advisor has been identified. The Doctor of Philosophy in Molecular be established that the student must fulfill student’s program of study will be under the Pharmacology and Toxicology to continue in the program. Passing this direction of a guidance committee composed This program emphasizes basic as well as screening procedure is prerequisite to con- of at least five members, one of whom must applied research in various aspects of drug tinuation in the Ph.D. program. discovery and molecular and behavioral 832 USC School of Pharmacy

Qualifying Examination Doctor of Philosophy in Pharmaceutical form his or her guidance committee within Students will be required to pass a comprehen- Economics and Policy one month after passing the departmental sive qualifying examination in major areas of The Department of Pharmaceutical screening procedure. molecular pharmacology, including fundamen- Economics and Policy (School of Pharmacy) tal principals of molecular and cellular biol- offers a program of study leading to the Ph.D. Screening Procedure ogy. The examination is administered by the degree. This program focuses on economic The student’s progress will be reviewed after guidance committee and consists of two parts: assessment of pharmaceuticals and medical each semester and before registration for any a written examination administered to all stu- technology and research into the finance and additional course work to determine if prog- dents at the end of their second year of study delivery of pharmaceuticals and pharmacy ress has been satisfactory. and a written proposal outlining the disserta- services. A minimum of 64 units of gradu- tion goals, and its oral presentation and defense ate level courses numbered 500 or higher Seminar Requirements by the student to the guidance committee. (excluding 794) and a minimum of four units Every student is required to take and satis- The examination process is conducted by the of 794 is required. factorily complete 8 units of research semi- student’s advisory committee with oversight by nars chosen from PMEP 698 or the equiva- the graduate affairs committee. The qualifying Foreign Language Requirement lent. At least one of these seminars must examination must be completed within three There is no formal foreign language require- be related to the student’s major field and years after admission, unless an extension is ment. However, competence in the use the same seminar may be taken more than obtained from the guidance committee. of one computer programming language once. Before completing the dissertation, is required for the graduate degrees. Such the student must present at least one origi- Annual Research Appraisal (ARA) competence can be demonstrated either by nal research paper in a seminar of his or her Beginning in the third year, each graduate course work or examination. choice. This paper should typically consist student will meet with the guidance com­ of original results contained in the student’s mittee and present a progress report on his Grade Point Average dissertation. It becomes part of the student’s or her research. Prior to the meeting the stu- A grade point average of at least 3.0 (A = 4.0) permanent file. dent will present a short written document must have been achieved on graduate course describing significant experiments during the work at USC. ECON 615 or a higher level Dissertation Proposal Preparation past year, problems and projected studies. course in econometrics must be completed The student is required to register for two This document is distributed to the commit- with a grade of B or higher. units of PMEP 790 and write a research tee members and is included in the student’s paper on a topic suitable for a dissertation. file. The oral ARA meeting is intended to Unit Requirements and Recommended Courses Typically, the chair of the student’s guidance be a working session between the student Students are required to complete a minimum committee directs this work. The resulting and the guidance committee. Experimental of 64 units of graduate level course work. The essay becomes part of the student’s written results and problems are discussed in this following courses are recommended towards dissertation proposal which is presented and context, as well as a research plan for the next fulfilling the 64-unit requirement: ECON critiqued during the oral portion of the quali- year of work. A satisfactory ARA is required 401, ECON 500, ECON 511, ECON 513, fying examination. for each year in the graduate program. ECON 514, ECON 615, PM 511a, PMEP 509, PMEP 519, PMEP 529, PMEP 538, PMEP Qualifying Examination Dissertation 539, PMEP 549 and PMEP 698. Students may Upon successful completion of the first two A dissertation based on original investigation transfer and substitute up to 24 units of gradu- years of course and grade requirements, in a relevant scientific area is required for ate course work from other universities to the student takes a general written and oral the Ph.D. The dissertation research should fulfill the required 64 units of graduate credit examination on the chosen area of research demonstrate the student’s ability to under- subject to the approval of the department. emphasis after presenting a detailed written take independent research through planning, dissertation proposal. After passing these conducting and evaluating experiments. The Guidance Committee examinations, the student is admitted to can- dissertation research must represent a sig- The student will be assigned to a member of didacy for the Ph.D. degree. nificant contribution to knowledge. A public the graduate faculty who will serve as his or oral defense of the dissertation will be held her temporary advisor until the formation of Dissertation after the candidate submits the final draft a guidance committee. The student should After admission to candidacy, the student of the dissertation to the dissertation com- consult the pharmaceutical economics and forms a dissertation committee comprising mittee, and it is approved by the graduate policy director of graduate studies on the three faculty members, one of whom must be advisor and dissertation committee. For addi- appointment of a Ph.D. guidance committee from an outside department. The chair of this tional details, see Theses and Dissertations, after taking the written qualifying examina- committee is the dissertation supervisor. The page 96. tion. The chairman of the student’s Ph.D. student must register for PMEP 794 each guidance committee advises the student on semester, excluding summer sessions, until Student Teaching matters of curriculum and graduate opportuni- the dissertation and all other degree require- Teaching experience is considered an inte- ties. The guidance committee comprises three ments are completed. gral part of the training of graduate students. to five members, at least one of whom must As part of the general requirements for the be from outside the department; at least two The student is expected to complete a dis- Ph.D. degree, each student is required to members must specialize in the student’s area sertation based on original investigation. The participate in the teaching program of the of emphasis; and at least three of the members dissertation must represent a significant con- School of Pharmacy. must be suitable for service on the student’s tribution to knowledge and must be defend- dissertation committee. The composition of all ed in an oral examination administered by Ph.D. guidance committees must be approved the dissertation committee (see the section by the pharmaceutical economics and policy on Theses and Dissertations, page 96). director of graduate studies. The student must Graduate Degrees 833

Student Teaching product development and toxin-related mat- Both professions require passing a state board Teaching experience is considered an inte- ters. This dual degree program provides qual- or bar exam to practice the respective profes- gral part of the training of graduate students. ified students with an efficient mechanism sions. Neither of these professional doctoral As part of the general requirements for the for obtaining the expertise and professional degrees requires a thesis or comprehensive Ph.D., all students are required to undergo credentials that will enable them to develop final exam. training as an educator. This will include professional practices that bring together participating in seminars on educational tech- expertise in both areas. Recommended Program niques and hands-on teaching experiences Pharm.D./J.D. dual degree students will begin through participation in didactic and small Overall Requirements with the first year of the Pharm.D. curriculum group teaching in the School of Pharmacy. A student is required to complete all work (36 units). During the second year, students for both degrees within six years of the date will take the first year law core (33 units), plus Pharm.D./Juris Doctor of matriculation at the School of Pharmacy 3-5 Pharm.D. units. Due to the rigor of the Admission Requirements (Pharm.D.) and five years of matriculation law school core, pharmacy courses during the Admission to the dual Pharm.D./J.D. program at the Gould School of Law (J.D.). The entire first year of law school are limited to non- is competitive, and involves meeting admis- dual degree program will take six years to science courses. The third through fifth sion requirements and gaining acceptance to complete. Dual degree students will be years of the program focus on Pharm.D. both the School of Pharmacy and the USC allowed to use 12 units of approved J.D. courses with sufficient law courses to main- Gould School of Law. Students will not be course work (elective or required) to meet tain students’ educational momentum in law. given special consideration for admission to 12 units of Pharm.D. electives and 12 units Students should complete their Pharm.D. either program because they are applying of approved Pharm.D. course work (elective requirements during the fall of their sixth year for the dual degree. Students who have a or required) to meet J.D. electives. A faculty of the program and their law course work also baccalaureate degree may apply to the dual guidance committee will determine the during the sixth year. Students must complete Pharm.D./J.D. degree program in two ways. exact program for each student, including both degree requirements by the end of the First, they may apply at the time they submit the appropriateness of courses in one pro- sixth year of the program. their Pharm.D. application by concurrently gram used to meet elective requirements for submitting applications to both schools. the other program. A total of 208 units are Pharm.D./M.B.A. Dual Degree Program Students who elect this approach must iden- required for the dual degree. Responding to the growing demand on phar- tify themselves on their Pharm.D. applica- macists to be knowledgeable in both science tions as potential dual Pharm.D./J.D. degree Pharm.D. Requirements and business administration, the USC School students. Students who are admitted to both Dual degree students must successfully com- of Pharmacy in 1988 helped pioneer an inno- schools will be offered admission to the dual plete 144 units of Pharm.D. and acceptable vation in pharmaceutical education by offer- degree contingent on passing all courses in J.D. units to receive the Pharm.D. degree. ing this unique five-year dual degree program. their first year of the Pharm.D. with a mini- The 144 units must include 132 units of mum 3.0 GPA. Students pursuing the dual required and elective pharmacy course work The Pharm.D./M.B.A. dual degree program Pharm.D./J.D. degree must notify the law plus 12 units of J.D. course work deemed is offered cooperatively by the School of school in a timely fashion that they will be acceptable to meet Pharm.D. elective require- Pharmacy and the USC Marshall School of enrolling in the dual Pharm.D./J.D. degree ments. Dual degree students should graduate Business. Students must complete concur- program and will not matriculate at the law with their Pharm.D. degrees at the comple- rently all requirements established by both school until the following year. Students who tion of the first semester of the sixth academic schools for their respective degrees. are accepted by only one school may choose year of the dual degree program. Students to attend that school but will not be eligible will be eligible to sit for the Pharmacy Board The program involves completion of the first for the dual degree. Second, students can Exams after completion of the Pharm.D. year in the School of Pharmacy, the second apply to the dual degree by submitting an degree requirements. However, dual degree in the Marshall School of Business, and then application to the Gould School of Law students will not actually be awarded their completion of the balance of both degrees during their first year of enrollment in the Pharm.D. degrees until they complete during the third through fifth years. A total of Pharm.D. program prior to the law school’s requirements for both degrees. 48 units must be completed in the Marshall published application deadline. Students who School of Business. elect this approach must apply through the Juris Doctor Requirements School of Pharmacy. Students who are admit- Dual degree students must successfully First Year: Required Pharmacy School courses ted to the law school using this approach complete 88 units of J.D. and acceptable would be offered admission to the dual Pharm.D. course work during the second to Second Year: Required M.B.A. core courses degree contingent on passing all courses in sixth years of the dual degree program to their first year of the Pharm.D. with a mini- receive the J.D. degree. The 88 units must Third to Fifth Years: 108 units of Pharmacy mum 3.0 GPA. See the admissions section of be composed of 76 units of J.D. course work, courses and graduate business electives suffi- the School of Pharmacy and the Gould School including satisfaction of the upper-division cient to bring the total units completed in the of Law for specific requirements. writing requirement and any other substan- Marshall School of Business to at least 48. tive requirements, plus 12 units of Pharm.D. Degree Requirements course work deemed acceptable to meet J.D. The Pharm.D. and the M.B.A. are awarded The professions of pharmacy and law are elective requirements. No J.D. credit will simultaneously upon completion of the distinctly different, yet pharmacists are often be awarded for Pharm.D. course work com- School of Pharmacy and the Marshall School involved in legal issues and lawyers frequent- pleted prior to matriculation in the law school. of Business requirements. ly deal with pharmacy, drug, health care, Students cannot receive the J.D. degree under requirements for the dual degree pro- gram without prior or simultaneous comple- tion of the Pharm.D. degree. 834 USC School of Pharmacy

Admission Requirements but will not be eligible for the dual degree. The Pharm.D./M.P.H. program spans five Students who have a baccalaureate degree Second, students can apply to the dual degree years (four years of pharmacy school courses from an accredited college or university by submitting an application to the M.S. and one year of public health courses). and have been admitted and have success- program during their first year of enrollment Students begin the core M.P.H. courses follow- fully completed one year in the School of in the Pharm.D. prior to the M.S. published ing the successful completion of the first year Pharmacy will be considered for admission application deadline. Students who elect this of pharmacy school. The last three years of the to the Marshall School of Business. See the approach must apply through the School of program are devoted to course work and the Marshall School of Business, page 158, for Pharmacy. Students admitted to the M.S. clinical rotations of the School of Pharmacy admission requirements. program using this approach will be offered and to the completion of the elective courses admission to the dual degree contingent on and practicum (field experience) of the M.P.H. Pharm.D./M.S., Gerontology passing all courses in their first year of the program. The emerging impact of the elderly on the Pharm.D. with a minimum 3.0 G.P.A. Students health care system has created a need for accepted to the dual degree program must All students in the Pharm.D./M.P.H. program health care providers who understand the maintain a minimum 3.0 G.P.A. in their must meet course requirements, grade point unique health-related needs of the elderly. As Gerontology and Pharm.D. courses. average requirements and program residency drug therapy remains the primary therapeutic requirements of both programs. Students must option for chronic disease, the demand for Recommended Program have a cumulative GPA of 3.0 in the Pharm.D. prescription drugs will continue to rise. There First year: Required Year I Pharm.D. course curriculum and a 3.0 in the M.P.H. curriculum is a demand for pharmacists who are equipped work to meet graduation requirements. to meet the pharmaceutical care needs of this population. Geriatric pharmacy is becom- Second year: Required Gerontology course The Pharm.D. and the M.P.H. degrees are ing increasingly recognized as a specialty. work awarded simultaneously upon completion of Pharmacists with expertise in gerontology the School of Pharmacy and the Master of and geriatrics are in an excellent position to Third year: Required Year II Pharm.D. course Public Health requirements. play a leading role in health policy and direct work patient care. The Pharm.D./M.S., Gerontology Admission Requirements and Procedures program will provide extensive education Fourth year: Required Year III Pharm.D. Students applying for the dual degree program and training in the unique health care needs course work must meet the respective admission require- of older adults. It will allow student phar- ments for each program. This includes having macists with a career interest in geriatrics or Fifth year: Required Year IV Pharm.D. course completed a baccalaureate degree from an gerontology to work with health care plan- work accredited college or university with a mini- ning or delivery organizations to develop and mum GPA of 3.0 and having acceptable GRE implement progressive pharmaceutical care Graduation Requirements and TOEFL scores as applicable. Students programs for the elderly. Students must complete all requirements will not be given special consideration for for the Pharm.D. (see page 825) and M.S., admission to either program because they are Application and Admission Requirements Gerontology degrees as listed in the current applying for the dual degree. Students may Students who would like to pursue the dual catalogue with a minimum cumulative 3.0 apply to the dual Pharm.D./M.P.H. degree Pharm.D./M.S. degree must be accepted by G.P.A. The specific M.S. course requirements program in two ways. First, they may apply at both programs. Students applying for the dual for the dual Pharm.D./M.S. degree are listed the time they submit their Pharm.D. applica- degree program must meet the respective on page 650. tion by concurrently submitting applications admission requirements for each program. to both programs. Students who elect this This includes having completed a bacca­ Pharm.D./Master of Public Health approach must identify themselves on both laureate degree from an accredited college or The School of Pharmacy and the Master of applications as potential dual degree students. university with a minimum G.P.A. of 3.0 and Public Health program, in recognition of the Students who are admitted to both programs a minimum GRE score of 1000. Students will rapidly changing health care environment, will be offered admission to the Pharm.D. and not be given special consideration for admis- and in response to the growing demand will be offered admission to the dual degree sion to either program because they are apply- for pharmacists who are knowledgeable in program contingent on passing all courses in ing for the dual degree. Students may apply both pharmacy and population-based health their first year of the Pharm.D. with a mini- to the dual Pharm.D./M.S. degree program in care issues, have developed a dual degree mum 3.0 GPA. Students who are accepted by two ways. First, they may apply at the time program. The joint Pharm.D./M.P.H. degree only one program may choose to attend that they submit their Pharm.D. application by will enable graduates to be more responsive program, but will not be eligible for the dual concurrently submitting applications to both to today’s health care needs and will provide degree. Second, students can apply to the programs. Students who elect this approach training for pharmacists who seek to be dual degree by submitting an application to must identify themselves on both applications agents of change within the profession and to the M.P.H. program during their first year as potential dual degree students. Students assume leadership roles in the pharmacy field of enrollment in the Pharm.D. prior to the who are admitted to both programs will be and in public health at the local, state and M.P.H. published application deadline. offered admission to the Pharm.D. and will be national levels. Students who elect this approach must apply offered admission to the dual degree program through the School of Pharmacy. Students contingent on passing all courses in their first Students who are enrolled in the School of admitted to the M.P.H. program using this year of the Pharm.D. with a minimum 3.0 Pharmacy must apply to the Master of Public approach will be offered admission to the dual G.P.A. Students who are accepted only by one Health program no later than January of their degree contingent on passing all courses in program may choose to attend that program, first year. All requirements for admission to the their first year of the Pharm.D. with a mini- regular M.P.H. program must also be fulfilled mum 3.0 GPA. by dual degree applicants. Graduate Degrees 835

Pharm.D./M.S., Regulatory Science Pharm.D./Doctor of Philosophy Post-Pharm.D. Graduate Studies Regulatory science is that branch of knowl- The Doctor of Pharmacy/Doctor of Qualified students who wish to continue edge which relates the regulatory and legal Philosophy (Pharm.D./Ph.D.) program is graduate studies within the School of Phar­ requirements of biomedical product develop- designed to permit qualified Pharm.D. stu- macy upon completion of the Pharm.D. ment to the scientific testing and oversight dents with a bachelor of science or equiva- may, with permission of the dean, substitute needed to ensure product safety and efficacy. lent degree to pursue research training in certain Pharm.D. courses with courses nec- The program provides an opportunity for the pharmaceutical sciences and toxicology. essary for the graduate degree so that the advanced preparation in the fields of regula- A student accepted into the joint program graduate program will not be delayed. These tory affairs, quality assurance and clinical must meet all requirements for the Pharm.D., units cannot, however, be substituted for the research. Students must complete concur- as well as the requirements for the Ph.D. in 24 units of core course work. rently all of the requirements established for the pharmaceutical sciences or toxicology the respective degrees. The program alter- sections listed in this catalogue. A maximum Pharm.D./Graduate Certificate in nates the courses required for the Pharm.D. of 20 units from the Pharm.D. program may Gerontology program during the fall and spring terms with be credited toward the Ph.D. Up to 12 units This integrated program in pharmacy and courses required in summer terms for the of these Pharm.D. courses may, at the dis- gerontology prepares students with an inter- M.S. program. Students will typically take cretion of the student’s Ph.D. advisor, be est in geriatric pharmacy to assume leadership courses in the summers of years two-four. counted toward the required 24 units of core roles at academic, administrative or policy Up to 12 appropriate units of course work course work. levels within the profession. The program from the Pharm.D. program can be applied involves the completion of 16 units of core toward the M.S. degree. The Pharm.D. and Admission Procedure area courses in physiology, psychology, sociol- the M.S., Regulatory Science degrees will be Students applying for the dual degree program ogy and social policy aspects of aging offered awarded simultaneously upon completion of must meet the respective admission require- by the USC Davis School of Gerontology. In requirements for the two programs. ments for each program. This includes having addition, students are required to complete completed a baccalaureate degree from an 8 units of approved elective courses in ger- Admission Requirements and Procedures accredited college or university with a mini- ontology or geriatric pharmacy to be credited Students applying for the dual degree program mum GPA of 3.0 and a minimum GRE score toward the requirements for the Pharm.D. and must meet the respective admission require- of 1000. Students will not be given special the Graduate Certificate in Gerontology. It is ments for each program and must have a bacca­ consideration for admission to either program expected that the program can be successfully laureate degree. Students will not be given because they are applying for the dual degree. completed by candidates taking electives in special consideration for admission to either Students may apply to the dual Pharm.D./Ph.D. geriatric pharmacy or gerontology during the program because they are applying for the degree program in two ways. First, they may regular semester and completing one core dual degree. Students may apply to the dual apply at the time they submit their Pharm.D. course in gerontology during each summer in Pharm.D/M.S., Regulatory Science degree pro- application by concurrently submitting appli- the four year Pharm.D. program. gram in two ways. First, they may apply at the cations to both programs. Students who elect time they submit their Pharm.D. application this approach must identify themselves on See the Davis School of Gerontology, by concurrently submitting applications to both both applications as potential dual degree page 689, for complete requirements. programs. Students who elect this approach students. Students who are admitted to both must identify themselves on both applications programs will be offered admission to the Admission Requirements as potential dual degree students. Students Pharm.D. and will be offered admission to the Students who have a baccalaureate degree who are admitted to both programs will be dual degree program contingent on passing from an accredited college or university offered admission to the Pharm.D. and will be all courses in their first year of the Pharm.D. must submit separate applications to the offered admission to the dual degree program with a minimum 3.0 GPA. Students who are School of Pharmacy and the Davis School of contingent on passing all courses in their first accepted by only one program may choose to Gerontology. All requirements for admission year of the Pharm.D. with a minimum 3.0 attend that program but will not be eligible for to the regular Pharm.D. program must be GPA. Students who are accepted by only one the dual degree. Second, students can apply to fulfilled by the candidate. GRE scores are program may choose to attend that program the dual degree by submitting an application not required for admission to the certificate but will not be eligible for the dual degree. to one of the Ph.D. programs in the School of program. Second, students can apply to the dual degree Pharmacy during their first two years of enroll- by submitting an application to the M.S. in ment in the Pharm.D. prior to the respective Regulatory Science program during their first published application deadlines for the Ph.D. or second year of enrollment in the Pharm.D. programs. Students who elect this approach prior to the M.S. in Regulatory Science pub- must apply through the Pharm.D. program. lished application deadline. Students who elect Students admitted to the Ph.D. program using this approach must apply through the School this approach will be offered admission to the of Pharmacy. Students admitted to the M.S. in dual degree contingent on their having main- Regulatory Science using this approach will be tained a minimum 3.0 GPA in the Pharm.D. offered admission to the dual degree contingent program. on passing all courses in their Pharm.D. studies with a minimum 3.0 GPA. 836 USC School of Pharmacy

Certificate Programs

Regulatory Science Program Additional options in specialized aspect of Quality/Risk Management Option: USC School of Pharmacy design or management (choose one): MPTX 515 Quality Systems and 1540 Alcazar St., CHP G32 MPTX 511 Introduction to Medical Standards 3 Los Angeles, CA 90089 Product Regulation 3 MPTX 526 Chemistry Manufacturing (323) 442-3102 MPTX 520 Risk Management for and Controls 3 Email: [email protected] Health Care Products 3 RSCI 520 Introduction to Risk regulatory.usc.edu PM 510L Principles of Biostatistics 4 Management for Health PM 511a Data Analysis 4 Care Products 2 Certificate in Clinical Research Design and PM 512 Principles of RSCI 529 Application of Risk Management Epidemiology 4 Management Tools and The graduate certificate in clinical research PM 523 Design of Clinical Studies 3 Techniques 2 design and management is designed to RSCI 527 Medical Product Safety 3 strengthen the statistical, research and project RSCI 528 Safety in the Health Care Certificate in Patient and Product Safety management skills of clinical researchers Environment 3 The graduate certificate in patient and prod- and their associated clinical team members. uct safety is a 12-unit program that educates Students must complete at least 12 units of Certificate in Food Safety students in the emerging field of safety and course work including at least two courses The graduate certificate in food safety is a risk management in the health care environ- in clinical design and trial management, one 12-unit program of course work designed to ment. It is designed to produce graduates course in ethics and one course in a special- strengthen the knowledge base and func- who have a particular expertise in the evalu- ized aspect of design, management or statis- tional “toolkit” of individuals who deal with ation and mitigation of medical errors and tics, subject to the approval of the program the production and management of food health-care product problems. Course work is director. The program will include course in industry and government. Students are typically delivered in nontraditional formats work delivered in nontraditional formats such required to take an entry level course that such as intensive weekend sessions and will as intensive weekend sessions and will use focuses on regulatory requirements for foods use distance learning tools, Web-cast lectures distance learning tools, Web-cast lectures and dietary supplements and two additional and study materials. Courses can be taken on and study materials. Courses can be taken on courses that focus on food science and food/ site, by distance or as a blended combination. site, by distance or as a blended combination. drug toxicology respectively. Final course Students should confirm their specific course Students should confirm their specific course work will be selected from a small grouping work plan in consultation with the gradu- work plan in consultation with the gradu- of electives that deal with quality systems or ate advisors before beginning the program. ate advisors before beginning the program. risk management. The program will include Students who have bachelor’s degrees from Students who have bachelor’s degrees from course work delivered in nontraditional for- accredited colleges or universities must sub- accredited colleges or universities must sub- mats, such as intensive weekend sessions, mit an application for graduate study through mit an application for graduate study through and will use distance learning tools, Web-cast the regulatory science program of the School the regulatory science program of the School lectures and study materials. Courses can be of Pharmacy. GRE scores are not required for of Pharmacy. GRE scores are not required for taken on site, by distance or as a blended admission to the certificate program. Students admission to the certificate program. Students combination. Students should confirm their are expected to enroll each semester until the are expected to enroll each semester until the specific course work plan in consultation program is completed. program is completed. with the graduate advisors before beginning the program. Students who have bachelor’s Students must complete 12 units of specified Requirements units degrees from accredited colleges or universi- course work, that normally will include an Introduction to Clinical Trials ties must submit an application for graduate introductory course in the basic principles of MPTX 517 Structure and Management study through the regulatory science program risk management, a second course in the use of Clinical Trials 4 of the School of Pharmacy. GRE scores are of risk management tools, and two additional not required for admission to the certificate courses in patient and product safety respec- Clinical Design/Statistics (choose one) program. Students are expected to enroll each tively as listed below. In addition, a course PM 510L Principles of semester until the program is completed. in medical ethics is recommended. Most Biostatistics 4 students will take the courses that are listed MPTX 522 Introduction to Clinical REquirements units in the sample student program below, but if Trial Design and Statistics 3 MPTX 514 Regulation of Food and students have already strong previous expe- Dietary Supplements 3 rience in risk management or safety, other Biomedical Ethics MPTX 524 Introduction to Food statistical or quality courses taught in gradu- MPTX 602 Science, Research and Science and Technology 3 ate programs at USC may be substituted with Ethics 2 RSCI 525 Introduction to Drug and the permission of the program director. The Food Toxicology 3 certificate can be completed on a part-time basis but must be finished within five years. Courses of Instruction 837

Requirements units Certificate in Preclinical Drug Development as intensive weekend sessions and will use MPTX 602 Science, Research and The graduate certificate in preclinical drug distance capabilities, Web-cast lectures and Ethics 2 development provides advanced foundational study materials. Courses can be taken on RSCI 520 Introduction to Risk training in preclinical aspects of drug devel- site, by distance or as a blended combination. Management for Health opment, translational research and regulatory Students should confirm their specific course Care Products 2 control. Students must complete at least work plan in consultation with graduate advi- RSCI 527 Medical Product Safety 3 12 units of course work including at least sors before beginning the program. Students RSCI 528 Safety in the Health Care three courses in preclinical design and devel- who have baccalaureate degrees from accred- Environment 3 opment (typically, RSCI 530 Translational ited colleges or universities must submit an RSCI 529 Application of Risk Medicine: An Overview; RSCI 531 Drug application for graduate study through the Management Tools Discovery; RSCI 532 Early Stage Drug regulatory science program of the School of and Techniques 2 Development) and one course in a related Pharmacy. GRE scores are not required for aspect of research design, regulation or eth- admission to the certificate program. Students ics, subject to the approval of the program are expected to enroll each semester until the director. The program will include course program is completed. work delivered in nontraditional formats such

Non-Degree Programs

Office of External Programs Continuing Education Programs are designed to educate pharma- 1985 Zonal Avenue The School of Pharmacy, Office of External cists about current issues in pharmaceutical Los Angeles, CA 90089-9121 Programs, is a recognized provider of con- care, practice management, therapeutics (323) 442-2403 tinuing pharmacy education and certificate and other topics of professional interest. FAX: (323) 442-3600 programs accredited by the Accreditation Continuing education programs are held at Email: [email protected] Council for Pharmacy Education (ACPE) and the School of Pharmacy, prior to many local www.usc.edu/schools/pharmacy/ recognized by the California State Board of and national association meetings, and annu- continuing_education Pharmacy and throughout the United States. ally in Las Vegas and Hawaii.

The school serves as a primary educational For information concerning continuing edu- resource for pharmacists in California and as cation programs contact: Office of External a supplementary resource for other health Programs. professionals and pharmacists, nationally and internationally.

Courses of Instruction

Molecular Phar m a c o l o g y a n d MPTX 501 Molecular Pharmacology and MPTX 512 Regulation of Pharmaceutical Toxicology (MPTX) Toxicology II (4, Sp) The second part of and Biological Products (3, Sm) Ensur- the two-semester course covers the general ing safety and effectiveness of new drugs The terms indicated are expected but are not aspects of molecular pharmacology and toxi- and biologics; marketing and monitoring guaranteed. For the courses offered during any cology on the basis of biochemical, molecular, approved pharmaceutical/biological products; given term, consult the Schedule of Classes. biological and environmental approaches. management of genetically engineered prod- Prerequisite: MPTX 500. ucts. Recommended preparation: undergraduate MPTX 500 Molecular Pharmacology and degree in pharmacy, medicine or indepen- Toxicology I (4, Fa) This is the first part of a MPTX 511 Introduction to Medical Product dent health sciences, engineering or equivalent two-semester introductory and survey course Regulation (3, Sm) Introduction to regulatory mix of post-secondary training and industry for the molecular pharmacology and toxicol- environments surrounding medical product experience. ogy degree program. Prerequisite: knowledge development, manufacturing and marketing; of biochemistry. operation of federal, state and international MPTX 513 Regulation of Medical Devices regulatory bodies. Recommended preparation: and Diagnostics (3, Sm) Development and undergraduate degree in pharmacy, medicine testing of new medical products according or independent health sciences, engineering to U.S. and international regulatory require- or equivalent mix of post-secondary training ments. Recommended preparation: under- and industry experience. graduate degree in pharmacy, medicine or independent health sciences, engineering or equivalent mix of post-secondary training and industry experience. 838 USC School of Pharmacy

MPTX 514 Regulation of Food and Dietary MPTX 526 Chemistry Manufacturing and MPTX 790 Research (1-12, FaSpSm) Supplements (3, Sm) Regulation and testing Controls (3, Fa) Provides a firm foundation in Research leading to the doctorate. Maxi- of foods, food additives and dietary supple- the domestic and international CMC process, mum units which may be applied to the ments in the U.S. and abroad. Recommended from concept to commercialization of new degree to be determined by the department. preparation: undergraduate degree in phar- active pharmaceutical ingredients and prod- Graded CR/NC. macy, medicine or independent health sci- ucts. Recommended preparation: undergraduate ences, engineering or equivalent mix of post- degree in pharmacy, medicine or independent MPTX 794abcdz Doctoral Dissertation secondary training and industry experience. health science, engineering or equivalent. (2-2-2-2-0, FaSpSm) Credit on acceptance of dissertation. Graded IP/CR/NC. MPTX 515 Quality Systems and Standards MPTX 531 Cell Biology (4) (Enroll in (3, Sm) Principles of quality assurance and INTD 531) quality control for medical-product develop- pharmacy (phrd) ment and manufacture. Recommended prepa- MPTX 561 Molecular Genetics (4, Sp) ration: undergraduate degree in pharmacy, (Enroll in INTD 561) PHRD 501 Pharmaceutics I (4, Fa) Introduc- medicine or independent health sciences, tion to physiochemical principles of dosage engineering or equivalent mix of post- MPTX 571 Biochemistry (4, Sp) (Enroll in forms; properties of molecules in dosage ­secondary training and industry experience. INTD 571) forms, stability of pharmaceuticals and their interactions in body tissue, including com- MPTX 516 Medical Products and the Law MPTX 572 Systems Physiology and putational approaches. Open to Doctor of (3, Fa) Legal issues affecting intellectual ­Disease I (4, Fa) (Enroll in INTD 572) Pharmacy students only. (Duplicates credit in property, medical product development, former PHAR 303.) marketing and safety, taught through case MPTX 573 Systems Physiology and studies and lectures. Recommended preparation: ­Disease II (4, Sp) (Enroll in INTD 573) PHRD 502 Pharmaceutics II (3, Sp) Principles undergraduate degree in pharmacy, medicine involved in molecules movement across or independent health sciences, engineering MPTX 590 Directed Research (1-12, FaSpSm) biological barriers. Properties, characteristics, or equivalent mix of post-secondary training Research leading to the master’s degree. application of homogeneous and hetero- and industry experience. Maximum units which may be applied to the geneous dosage forms, liquid, semi-solid degree to be determined by the department. and solid. Open to Doctor of Pharmacy MPTX 517 Structure and Management of Graded CR/NC. students only. (Duplicates credit in former Clinical Trials (4, FaSpSm) Development and PHAR 306L.) execution of clinical trials: bioethical princi- MPTX 594abz Master’s Thesis (2-2-0, ples, good clinical practices, project manage- FaSpSm) Credit on acceptance of thesis. PHRD 503 Biological Systems I (4, Fa) ment and documentation. Graded IP/CR/NC. Integrated teaching of anatomy, histology, physiology and pathophysiology using an MPTX 518 Writing Regulatory Drug Sub- MPTX 599 Special Topics (2-4, max 8) organ-based approach. Open to Doctor of missions (3, Sp) Developing form and con- ­Special topics in Molecular Pharmacology Pharmacy students only. (Duplicates credit tent for investigational drug applications, new and Toxicology. in former PHAR 309, PHAR 313, PHAR 314 drug applications, biologic licensing applica- and PHAR 419.) tions to FDA; common technical documents; MPTX 602 Science, Research and Ethics considerations of writing style. (2, Fa) A discussion of the unique technologi- PHRD 504 Biological Systems II (6, Sp) cal and philosophical issues that challenge Continued­ integrated teaching of anatomy, MPTX 519 Global Regulation of Medical modern scientists and a discernment of ethi- histology, physiology and pathophysiology, Products (3, Fa) Regulatory requirements cal responses to those challenges. using an organ-based approach. Open to Doc- governing medical products in European tor of Pharmacy students only. (Duplicates Union, Asia and other global markets. MPTX 603 Molecular Mechanisms for credit in former PHAR 310 and PHAR 419.) ­Biological Signals (4, Fa) Biological mecha- MPTX 520 Risk Management for Health nisms of hormone, neuro-transmitter, growth PHRD 505 Molecular Genetics and Therapy Care Products (3, Sp) Risk assessment and factor and xenobiotic actions from ligand- (3, Fa) Principles of gene expression, and management techniques, including FMEA, receptor interactions, signal transductions, recombinant DNA methods and applications. HACCP, HAZAP, human factors analysis; pol- modification processes to regulation of gene Focus on human genetics and influence of icies, regulations, requirements and standards; expression and cellular growth. Prerequisite: genetic background on the utilization and loss control and liability prevention. knowledge of physiology and biochemistry. effectiveness of drugs. Open to Doctor of Pharmacy students only. (Duplicates credit in MPTX 522 Introduction to Clinical Trial MPTX 630 Directed Field-Research Project former PHAR 316.) Design and Statistics (3) Clinical designs (6, FaSpSm) Research/policy analysis con- and statistics commonly used to test medical ducted under preceptor supervision in an PHRD 506 Self Care and Non-Prescription products in general populations and special industrial or governmental setting. Open to Therapies (5, Fa) Facilitate patient selection patient groups. students who have completed the majority of self-care health care products: OTC drugs, of course credits in the Regulatory Science dosages, pharmacology, efficacy, cost, side MPTX 524 Introduction to Food Science and program. Graded CR/NC. effects, adverse reactions, contraindications, Technology (3, Sm) Discusses the basic and and interactions with other medications. applied concepts of food science and food MPTX 700 Seminar in Molecular Pharma­ Open to Doctor of Pharmacy students only. safety, and demonstrates the principles of cology and Toxicology (1, max 8, FaSp) (Duplicates credit in former PHAR 331 and food chemistry, sensory evaluation, and prod- Contemporary advances in molecular phar- PHAR 332.) uct development. Recommended preparation: macology and toxicology research. Registra- undergraduate degree in biological sciences tion required during each year of residency. or related disciplines. Courses of Instruction 839

PHRD 507 Health Care Delivery Systems PHRD 554 Public Health and Epidemiology PHRD 603 Therapeutics VI (3, Fa) Integrated (2, Fa) Introduction to understanding the (2, Sp) Introduction to epidemiology, envi- teaching of biomedicinal chemistry, pharma- structure of the health care system. Includes ronmental health, health education, health cology, clinical pharmacokinetics and thera- health care financing and the role of phar- care organizations and financing. Orientation peutics of drugs with an emphasis on phar- macy and the pharmacist in health systems. to social and governmental controls on the maceuticals affecting the endocrine diseases, health care system. Open to Doctor of Phar- systems and women’s health. Open to Doctor PHRD 508 Pharmacy Literature Analysis macy students only. (Duplicates credit of Pharmacy students only. (Duplicates credit and Drug Information (3, FaSp) Literature in former PHAR 437.) in former PHAR 548 and PHAR 549.) evaluation and biostatistics of clinical and health services research, and drug informa- PHRD 555 Biochemical and Molecular Sites PHRD 605 Therapeutics VII (4, Fa) Integrated tion services. Emphasis on drug therapy, of Drug Action (4, Fa) Basic principles of teaching of the biomedicinal chemistry, patient outcomes, and formulary develop- drug action and receptor actions. Includes pharmacology, clinical pharmacokinetics, ment. Open to Doctor of Pharmacy students their application to the understanding and and therapeutics of drugs; with emphasis on only. (Duplicates credit in former PHAR 319 treatment of disease. Provides the scientific chemotherapy of infectious disease: bacte- and PHAR 366.) basis of pharmaceutical action. rial, microbial, viral, parasitic, and fungal. (Duplicates credit in former PHAR 411L, PHRD 509 Pharmacy Practice and Experi- PHRD 557 Therapeutics I (5, Fa) Introduction PHAR 418.) ence I (4, Fa) Introduction of principles and to principles of pharmacology, pharmaco­ the application of pharmaceutical care in kinetics, medicinal chemistry and therapeu- PHRD 606 Therapeutics VIII (2, Sp) community or hospital pharmacy setting. tics. Open to Doctor of Pharmacy students Advanced topics and clinical therapeutics Includes communications, basic practice only. (Duplicates credit in former PHAR of drugs, with emphasis on the treatment of skills, career pathways and leadership. Open 403L, PHAR 414 and PHAR 418.) infectious disease: bacterial, microbial, viral, to Doctor of Pharmacy students only. (Dupli- parasitic and fungal. (Duplicates credit in for- cates credit in former PHAR 361, PHAR 363, PHRD 559 Therapeutics II (2, Fa) Integrated mer PHAR 411L, PHAR 418.) PHAR 365 and PHAR 450.) teaching of pharmacogenomics and biotech- nology with emphasis on general principles, PHRD 607 Nutrition (2, Fa) Biomedical PHRD 510 Pharmacy Practice and Experi- diagnostics, and future technology. knowledge is correlated with assessments ence II (4, Sp) Introduction of principles of clinical case-management problems to and the application of pharmaceutical care PHRD 560 Therapeutics III (6, Sp) Inte- understand the interrelationship between in community or hospital pharmacy setting. grated teaching of biomedicinal chemistry, nutrition and health in both hospitalized and Includes calculations, drug information, and pharmacology, clinical pharmacokinetics, healthy patients. Open to Doctor of Pharmacy basic practice skills. Open to Doctor of Phar- and therapeutics of drugs, with emphasis on students only. (Duplicates credit in former macy students only. (Duplicates credit in for- pharmaceuticals treating diseases associated PHAR 422.) mer PHAR 362, PHAR 368 and PHAR 450.) with the central nervous system. Open to Doctor of Pharmacy students only. (Dupli- PHRD 608 Therapeutics IX (2, Sp) Integrated PHRD 551 Immunology (3, Fa) Basic prin- cates credit in former PHAR 547.) teaching of biomedicinal chemistry, pharma- ciples of immunology and their application cology, clinical pharmacokinetics and thera- to the understanding and treatment of PHRD 561 Parenteral Therapy Externship peutics of drugs, with emphasis on pharma- ­immunologically-mediated diseases. Provides (3, FaSpSm) Drug weight/volume concen- ceuticals for managing oncological diseases. the scientific basis of immunotherapy and trations, dilutions and additive volumes are Open to Doctor of Pharmacy students only. immunodiagnosis. Open to Doctor of Phar- calculated in compounding of parenteral (Duplicates credit in former PHAR 550 and macy students only. (Duplicates credit in products in various patient-care settings using PHAR 562.) former PHAR 441.) aseptic technique. Open to Doctor of Phar- macy students only. (Duplicates credit in for- PHRD 610 Therapeutics X (3, Sp) Focuses PHRD 552 Pharmaceutics III (3, Sp) Prin- mer PHAR 414, PHAR 460 and PHAR 545.) on the pharmacology, pharmacokinetics, ciples and applications of controlled, targeted, medicinal chemistry and clinical therapeutics and self-regulating drug delivery. Methods PHRD 562 Therapeutics IV (4, Sp) Integrated that apply to pharmaceutical care of pediatric, to deliver therapeutic peptides, proteins and teaching of biomedicinal chemistry, pharma- geriatric and chronic pain patients. genetic materials. Open to Doctor of Phar- cology, clinical pharmacokinetics, and thera- macy students only. (Duplicates credit in peutics of drugs with an emphasis on treating PHRD 612 Therapeutics XI (2, Sp) Updates former PHAR 406.) diseases of the renal, GI and pulmonary sys- students on recent advances in clinical areas, tems. Open to Doctor of Pharmacy students prepares students for advanced practice expe- PHRD 553 Management within Health Care only. (Duplicates credit in former PHAR 548 riences and assessment of clinical readiness Organizations (2, Fa) Management of the and PHAR 549.) via a final examination. Graded CR/NC. professional practice of pharmacy in orga- nized health care systems. Introduction to PHRD 601 Therapeutics V (6, Fa) Inte- PHRD 614 Pharmaceutical Economics and formulary development and outcome analy- grated teaching of biomedicinal chemistry, Outcome Studies (3, Sp) Economic analysis sis. Open to Doctor of Pharmacy students pharmacology, clinical pharmacokinetics, of the U.S. health care system, the pharma­ only. (Duplicates credit in former PHAR 431 and therapeutics of drugs, with emphasis ceutical industry, and the profession; eco- and PHAR 432.) on pharmaceuticals affecting cardiovascular nomic assessment of drug therapy costs and and circulatory diseases. CPR certification. health care outcomes applying pharmaco­ Open to Doctor of Pharmacy students only. economic research methodologies. Open to (Duplicates credit in former PHAR 546.) Doctor of Pharmacy students only. (Dupli- cates credit in PHAR 406 and PHAR 553.) 840 USC School of Pharmacy

PHRD 616 Pharmacy, Law and Ethics (3, Sp) PHRD 657L Basic Research Design (3, max 6, PHRD 665 Complementary/Alternative To provide students with an understanding FaSp) Research experience to integrate Therapeutics (3, FaSp) Examines the thera- of ethical issues that arise in pharmacy prac- research into Doctor of Pharmacy program. peutic use of complementary/alternative tice along with state and federal statutes, Research focuses on industrial, academic, medicines, such as herbal medicines, homeo- regulations, and pharmacy-related cases. or governmental issues. Open to Doctor of pathic drugs, vitamins and other nutritional Open to Doctor of Pharmacy students only. Pharmacy students only. supplements. Open to Level III Pharm.D. (Duplicates credit in former PHAR 552 and students only. (Duplicates credit in former PHAR 554.) PHRD 658 Sleep and the Pharmacologic PHAR 579.) Management of Its Disorders (3, FaSp) PHRD 651 Community Pharmacy I (3, Fa) Overview of normal sleep manifestations, and PHRD 666 Therapeutic Drug Monitoring Development of specialized knowledge treatment of common sleep disorders, and (3, FaSp) Application of pharmacokinetic and and skills in community pharmacy prac- the pharmacist’s role in assessment, treat- pharmacodynamic principles to individualize tice involving location analysis, pharmacy ment, and referral. Open to Level III Doctor patient drug regimens. Open to Level III management principles, and introduction to of Pharmacy students only. (Duplicates credit Pharm.D. students only. (Duplicates credit in business law concepts. Open to Doctor of in former PHAR 570.) former PHAR 575.) Pharmacy students only. (Duplicates credit in former PHAR 541 and PHAR 555.) PHRD 659 Molecular Therapeutics: Signal PHRD 667 Drugs of Abuse (3, FaSp) Spe- Transduction (3, FaSp) Principles of molecu- cialized knowledge and skills in specific PHRD 652 Community Pharmacy II (3, Sp) lar therapeutics against signaling pathways; substance abuse-related areas. Each area will A continuation of pharmacy business law emphasis on biological mechanisms underlying include addiction, wellness, and prevention concepts encompassing contract principles hormone, growth factor, and neurotransmitter- components. Open to Doctor of Pharmacy and forms of ownership, including a review of mediated gene regulation, proliferation, students only. (Duplicates credit in former pharmacy laws, compounding principles, and and cell death. Open to Level III Pharm.D. PHAR 568.) OTC agents. Open to Doctor of Pharmacy students only. (Duplicates credit in former students only. (Duplicates credit in former PHAR 573.) PHRD 668 Computing Application (3, FaSp) PHAR 556.) Prerequisite: PHRD 651. Specialized knowledge and skills using PHRD 660 Disease State Management I ­computers in professional practice: telecom- PHRD 653 Health Systems Pharmacy I (3, FaSp) The processes required to develop munication protocols, typical patient data- (3, Fa) Understanding formal and informal disease state management protocols based on bases in hospital and community pharmacies, organizations in institutions, managed care, data drawn from the medical research litera- drug interactions, insurance billing, inven- disease management, health care policy and ture. Open to Level III Doctor of Pharmacy tory control. Open to Doctor of Pharmacy financing, patients’ chart organization, and students only. (Duplicates credit in former students only. (Duplicates credit in former clinical monitoring parameters. Open to Doc- PHAR 571.) PHAR 568.) tor of Pharmacy students only. (Duplicates credit in former PHAR 541 and PHAR 557.) PHRD 661 Pharmacy Practice in Women’s PHRD 669 Health Care Needs of Special Health (3, FaSp) The pharmaceutical care of Populations (3, FaSp) Health care needs of PHRD 654 Health Systems Pharmacy II women patients is emphasized. Therapeutic, the poor will be examined through participa- (3, Sp) Recognizing resources available for psychosocial factors and current research in tion in a multidisciplinary community clinic drug information, familiarity with institu­ women’s health. Open to Level III Pharm.D. setting focusing on medication counseling tional formularies, medication counseling, students only. (Duplicates credit in former and compliance. Open to Level III Pharm.D. writing chart notes, and clinical activities at PHAR 577.) students only. (Duplicates credit in former an off-campus health care institution. Open PHAR 576.) to ­Doctor of Pharmacy students only. (Dupli- PHRD 662 Psychiatric Pharmacy Practice cates credit in former PHAR 558.) Prerequisite: (3, Sp) Specialized knowledge and skills in PHRD 670 Marketing and Development in PHRD 557. psychiatric pharmacy practice including child, the Pharmaceutical Industry (3, FaSp) Basic adult, and geriatric psychopharmacology and advanced strategies for marketing and PHRD 655 Geriatric Pharmacy I (3, Fa) applied to inpatient and outpatient treatment. development of new compounds or indica- Specialized­ knowledge and skills in geriatric Open to Level III Pharm.D. students only. tion in the pharmaceutical industry. Recom- pharmacy, pharmacology of aging, and unique (Duplicates credit in former PHAR 578.) mended preparation: PHRD 663. functions of health care team providing care to the elderly patient. Open to Doctor of PHRD 663 Pharmaceutical Development PHRD 671 Pharmacy Education Seminar Pharmacy students only. (Duplicates credit in (3, FaSp) Examination of pharmaceutical (3, FaSp) A seminar course with a focus on former PHAR 559.) product development process including dis- educational methods and teaching skills covery, preclinical/clinical studies, regulatory- providing career development for students PHRD 656 Geriatric Pharmacy II (3, Sp) legal issues, and marketing. Open to Doctor interested in academia. Open to Doctor of Specialized knowledge and skills in geron- of Pharmacy students only. (Duplicates credit Pharmacy students only. tology and geriatric pharmacy including the in former PHAR 566.) pathophysiology of selected cardiovascular, PHRD 677 Risk Assessment and Man- endocrine, genitourinary gastrointestinal dis- PHRD 664 Clinical Problem Solving (3, Sp) agement in Pharmacy Practice (3, FaSp) orders, osteoarthritis, and osteoporosis. Open Integration of physical assessment, laboratory Specific risk management issues, legal and to Doctor of Pharmacy students only. (Dupli- tests, history-taking, and diagnosis to formu- professional expectations of pharmacists, and cates credit in former PHAR 560.) Prerequisite: late decisions for optimal treatment plans assessing and avoiding risk. Open only to PHRD 559. in specific disease states. Open to Level III Doctor of Pharmacy students. Pharm.D. students only. (Duplicates credit in former PHAR 574.) Courses of Instruction 841

PHRD 701 Acute Care Clinical Practice Clerk- PHRD 708 Inpatient Clinical Practice Clerk- PHRD 717 Dermatology Clerkship (6, ship (6, FaSpSm) Application of pharma- ship (6, FaSpSm) Drug therapy in a variety FaSpSm) Provides experiences in disease ceutical care principles to the adult patient of inpatient clinical settings. Emphasis: states common to this area and the drug population in an acute care environment. patient monitoring, evaluation of therapeutic therapy management employed. (Duplicates Pharmacology, pharmacokinetics, and disease response, and provision of drug information. credit in former PHAR 619.) state management will be emphasized. Open (Duplicates credit in former PHAR 610.) to Doctor of Pharmacy students only. (Dupli- PHRD 718 Hospital Pharmacy Practice Clerk- cates credit in former PHAR 601.) PHRD 709 Pediatric Drug Therapy Clerkship ship (6, FaSpSm) Practical experience and (4-6, FaSpSm) Clinical therapeutic and phar- training in the practice of hospital pharmacy. PHRD 702 Inpatient Psychiatric Pharmacy macokinetic concepts applied to the pediatric Administrative, practice-based and therapeu- Clerkship (6, FaSpSm) Application of phar- patient. Unique aspects of pediatric ­clinical tic competencies emphasized. Open to Level maceutical care principles to the inpatient pharmacology emphasized in treating a vari- IV Doctor of Pharmacy students only. (Dupli- psychiatric patient. Understanding of the ety of organ system diseases. (Duplicates cates credit in former PHAR 620.) treatment of common psychiatric disorders, credit in former PHAR 611.) patient interviewing skills and health care PHRD 719 Pain Management Clerkship teams. Open to Level IV Doctor of Pharmacy PHRD 710 Surgery Clerkship (6, FaSpSm) (6, FaSpSm) Pharmaceutical care principles students only. (Duplicates credit in former Drug therapy in clinical situations common applied to patients requiring treatment in pain PHAR 602.) to surgical patients. The use of drugs and management. Pharmacology, patient counsel- monitoring for response to treatment in sur- ing and management emphasized. Open to PHRD 703 Long Term Care Clerkship (6, gical settings. Open to Level IV Doctor of Level IV Doctor of Pharmacy students only. FaSpSm) Application of pharmaceutical care Pharmacy students only. (Duplicates credit (Duplicates credit in former PHAR 623.) to patients in long term care environments. in former PHAR 612.) Understanding of the therapeutic, legal PHRD 720 Critical Care Clerkship (6, FaSpSm) and special needs of this patient popula- PHRD 711 Cardiovascular Drug Therapy Drug therapy in a critical care setting. tion. Open to Level IV Doctor of Pharmacy Clerkship (6, FaSpSm) Pharmaceutical care Emphasizes therapeutic management in criti- students only. (Duplicates credit in former applied to cardiac patients. The use of car- cally ill patients, often with multisystem fail- PHAR 603.) diac drugs with an emphasis on physiologic ure. (Duplicates credit in former PHAR 624.) response, pharmacokinetic principles and PHRD 704 Primary Care Clerkship (6, FaSpSm) desired treatment outcomes. Open to Level PHRD 721 Drug Utilization and Evaluation Disease state management and pharmaceuti- IV Doctor of Pharmacy students only. (Dupli- Clerkship (6, FaSpSm) Practical experience cal care in ambulatory care. Modification and cates credit in former PHAR 613.) and training in the design, implementation design of drug therapy regimens, participa- and evaluation instruments (DUE/MUE) to tion in medical care team and direct patient PHRD 712 Applied Clinical Pharmacokinetics measure the appropriate use of therapeutic care. Open to Doctor of Pharmacy students Clerkship (6, FaSpSm) Practical experience agents and the evaluation of desired thera- only. (Duplicates credit in former PHAR 604.) in applying pharmacokinetic principles to peutic outcomes. Open to Level IV Doctor of patients in the health care system. A variety Pharmacy students only. (Duplicates credit in PHRD 705 Community Pharmacy Clerkship of disease states and therapeutic agents will former PHAR 625.) (6, FaSpSm) Pharmaceutical care principles be reviewed. Open to Level IV Doctor of applied to the community pharmacy envi- Pharmacy students only. (Duplicates credit PHRD 722 Home Health Care Clerkship ronment. Participating in the development, in former PHAR 614.) (6, FaSpSm) Practical experience in the pro- implementation and outcome evaluation vision of comprehensive home intravenous of patient care services in the community. PHRD 713 Drug Information Clerkship and nutritional support services, including Open to Level IV Doctor of Pharmacy (6, FaSpSm) Practical experience and training fluid and electrolyte therapy, chemotherapy, students only. (Duplicates credit in former in the use of information resources and tech- antibiotics,­ pain control and nutrition sup- PHAR 605.) nology to improve patient care. Experience port. Open to Level IV Doctor of Pharmacy in information retrieval, literature evaluation, students only. (Duplicates credit in former PHRD 706 Geriatrics Clerkship (6, FaSpSm) problem solving skills and communication PHAR 626.) Drug therapy and management of geriatric skills emphasized. Open to Level IV Doctor patients with a focus on unique medical, of Pharmacy students only. (Duplicates credit PHRD 723 Nutritional Support Clerkship economic, and psycho-social problems of in former PHAR 615.) (6, FaSpSm) Experiential training in the this population. Open to Level IV Doctor of pharmacy specialty of nutritional support. Pharmacy students only. (Duplicates credit in PHRD 714 Radiopharmacy Clerkship Activities include: patient evaluation, devel- former PHAR 606.) (6, FaSpSm) Provides practical and theoreti- oping treatment plans, formula composition cal aspects of radiopharmacy services deliv- and design, integration with nutritional PHRD 707 Outpatient Psychiatric Pharmacy ery. (Duplicates credit in former PHAR 616.) support team and consult services. Open to Clerkship (6, FaSpSm) Disease state manage- Level IV Doctor of Pharmacy students only. ment and pharmaceutical care in ambulatory PHRD 715 Oncology Clerkship (6, FaSpSm) (Duplicates credit in former PHAR 627.) mental health care. Modification and design Directed experiences in the use and monitor- of psychiatric therapy regimens, participa- ing of oncological drugs. (Duplicates credit in PHRD 724 Advanced Community Pharmacy tion in multidisciplinary teams and patient former PHAR 617.) Clerkship (6, FaSpSm) Directed project in care. Open to Level IV Doctor of Pharmacy community pharmacy. (Duplicates credit in students only. (Duplicates credit in former PHRD 716 Ob-Gyn Clerkship (6, FaSpSm) former PHAR 628.) PHAR 604 and PHAR 607.) Provides experiences in disease states com- mon to this area and the drug therapy man- agement employed. (Duplicates credit in former PHAR 618.) 842 USC School of Pharmacy

PHRD 725 International Pharmacy Clerk- PHRD 733 Anticoagulation Therapy Clerk- PHRD 741 Advanced Primary Care Clerkship ship (6, FaSpSm) Practical experience and ship (6, FaSpSm) Management of patients (6, FaSpSm) Advanced experience in disease training in the practice of pharmacy in the requiring anticoagulation. Applied knowledge state management in the primary care setting. international setting. Students will visit an of disease pathophysiology, anticoagulant Design drug therapy regimens using a team- international pharmacy practice setting and pharmacology, and laboratory methods toward based approach at an advanced level of prac- complete a project. Open to Level IV Doctor safe and effective patient outcomes. Open to tice. Open to Doctor of Pharmacy students of Pharmacy students only. (Duplicates credit Level IV Doctor of Pharmacy students only. only. Prerequisite: PHRD 704. in former PHAR 629.) (Duplicates credit in former PHAR 634.)

PHRD 726 Directed Clinical Clerkship Project PHRD 734 Antimicrobial Therapy Clerkship Pharmaceutical Economics and I (6, FaSpSm) Directed educational oppor- (6, FaSpSm) Antimicrobial therapy, includ- Policy (PMEP) tunities not presently offered as electives, ing antibiotic selection, dosage adjustment, e.g., research projects or new and evolving and outcomes assessment of patients in the PMEP 509 Research Design (4, Fa) Intro­ clerkships. (Duplicates credit in former health care setting. Open to Level IV Doctor duction to the concept of research design and PHAR 630a.) of Pharmacy students only. (Duplicates credit examples of the variant research methods in former PHAR 635.) utilized in the field. Both the conceptual and PHRD 727 Directed Clinical Clerkship Project practical issues of research including devel- II (6, FaSpSm) Directed educational oppor- PHRD 735 Clinical Pharmacy Research Clerk- opment of the research question, selection tunities not presently offered as electives, ship (6, FaSpSm) Drug research administra- of appropriate methods, data sources and e.g., research projects or new and evolving tion: research design; ethics; record-keeping; analytic approaches to address the research clerkships. (Duplicates credit in former and institutional review. Practical experience question will be addressed. PHAR 630b.) and projects are emphasized. Open to Level IV Doctor of Pharmacy students only. (Dupli- PMEP 519 Survey Research and Quality of PHRD 728 Directed Clinical Clerkship Project cates credit in former PHAR 636.) Life Assessment (4, Sp) Skills to develop and III (6, FaSpSm) Directed educational oppor- assess surveys which are integral in Pharma- tunities not presently offered as electives, PHRD 736 Chemical Dependency Clerk- ceutical Economics and Policy research. e.g., research projects or new and evolving ship (6, FaSpSm) The psychiatric, social, Prerequisite: PMEP 509; recommended prepara- clerkships. (Duplicates credit in former and pharmacological management of chemi- tion: biostatistics, econometrics. PHAR 630c.) cal dependency. Emphasizes the inpatient, day treatment, and outpatient components PMEP 529 Risk, Probabilities and Prefer- PHRD 729 Directed Clinical Clerkship Project of detoxification and recovery. (Duplicates ences (4, Sp) Analysis of economic and psy- IV (6, FaSpSm) Directed educational oppor- credit in former PHAR 637.) chological constructs of risks, probabilities, tunities not presently offered as electives, and health related preferences and utilities. e.g., research projects or new and evolving PHRD 737 Clinical Transplantation Clerkship clerkships. (Duplicates credit in former (6, FaSpSm) Drug therapy to organ transplanta- PMEP 538 Pharmaceutical Economics (4, Sm) PHAR 630d.) tion. Emphasizes pre- and post-transplantation Introduction to pharmacoeconomics with therapy designed to minimize organ rejec- ­special emphasis on the role of pharmaceu- PHRD 730 Acute Care Geriatrics Clerkship tion, prevent infection, and improve survival. ticals and the pharmaceutical industry, insur- (6, FaSpSm) Pharmaceutical care principles (Duplicates credit in former PHAR 638.) ance, managed care, regulation and pricing. applied to the acutely ill geriatric patient Prerequisite: ECON 500. population. Emphasis on drug therapy prob- PHRD 738 Pharmaceutical Industry Clerk- lem solving, physiology, pharmacokinetics ship (6, FaSpSm) Train within a pharmaceu­ PMEP 539 Economic Assessment of Medical and compliance problems. Open to Level IV tical company to develop an understanding Care (4, Fa) Principles of cost-benefit analysis Doctor of Pharmacy students only. (Dupli- of the drug development, research, market- and medical cost-effectiveness analysis with cates credit in former PHAR 631.) ing process. (Duplicates credit in former applications in medical care and the pharma­ PHAR 639.) ceutical field. Prerequisite: ECON 500 and PHRD 731 Advanced Geriatrics Clerkship ECON 581. (6, FaSpSm) Directed projects and experi- PHRD 739 AIDS/Immune Disorders Clerk- ences in geriatric drug therapy. (Duplicates ship (6, FaSpSm) A multidisciplinary PMEP 549 Applied Pharmacoeconometrics credit in former PHAR 632.) approach to the management of AIDS and (4, Sp) Use of quantitative models to describe other immuno-compromised patients. Phar- and analyze pharmaceutical and health care PHRD 732 Pharmacy Administration Clerk- macologic management is directed toward markets; experimental design/power calcula- ship (6, FaSpSm) Principles and practices of opportunistic infections, disease modifiers, tions; survival models; multiple indicator hospital pharmacy administration, manage- and adjuvant therapy. (Duplicates credit in models; qualitative and limited dependent ment and departmental relationships. Practi- former PHAR 640.) variables models; estimation and application cal experiences and projects emphasized. of such models to selected problems. Prereq- Open to Level IV Doctor of Pharmacy PHRD 740 Health Care Systems Administra- uisite: ECON 615. students only. (Duplicates credit in former tion Clerkship (6, FaSpSm) Practical experi- PHAR 633.) ence and training in managed care settings and health care systems. Emphasis on admin- istrative principles, management and health outcomes. Students will complete a project. Open to Doctor of Pharmacy students only. (Duplicates credit in former PHAR 642.) Courses of Instruction 843

PMEP 590 Directed Research (1-12, FaSpSm) PSCI 655 Immunopharmaceutics (2, 2 years, PSCI 791L Research (2-12, no max) Research leading to the master’s degree. Fa) Lectures and discussion sessions on Directed research for the M.S. thesis or Ph.D. Maximum units which may be applied to the pharmaceutics-related immunology, including dissertation. degree to be determined by the department. drugs affecting the immune system, antibod- Graded CR/NC. ies and cytokines as drugs, and new develop- PSCI 794abcdz Doctoral Dissertation ments in immunobiotechnology. (2-2-2-2-0, FaSpSm) Credit on acceptance of PMEP 594abz Master’s Thesis (2-2-0, FaSp) dissertation. Graded IP/CR/NC. Credit on acceptance of thesis. Graded PSCI 661L Advanced Pharmaceutical Analy- IP/CR/NC. Prerequisite: completion of all sis (4, 2 years, Fa) Theory and application of required course work for the M.S. degree. quantitative instrumental techniques to the regulatory science (rsci) pharmaceutical sciences. Includes principles PMEP 698 Seminar in Pharmaceutical Eco- of chromatography, spectrophotometry, fluo- RSCI 520 Introduction to Risk Manage- nomics and Policy (4, max 8, FaSp) Current rescence, mass spectrometry and immuno- ment for Health Care Products (2) Historical research in pharmaceutical economics and logic assays. Lecture and laboratory. development, formal language and theoretical policy presented by outside scholars, faculty approaches to risk management in health care and students. Graded CR/NC. PSCI 662 Advanced Pharmacokinetics and medical product environment; policies, (4, 2 years, Sp) Principles of pharmacokinet- regulations, standards; liability prevention PMEP 790 Research (1-12) Research leading ics including mathematical description of drug and loss control. (Duplicates credit in MPTX to the doctorate. Maximum units which may disposition processes. Emphasis on design 520.) Recommended preparation: undergraduate be applied to the degree to be determined by and evaluation of pharmacokinetic studies degree in pharmacy, medical or independent the department. Graded CR/NC. and statistical analysis of parameter estimates. health sciences, engineering or equivalent mix of post-secondary training and industry PMEP 794abcdz Doctoral Dissertation PSCI 663 Advanced Drug Delivery Systems experience. (2-2-2-2-0) Credit on acceptance of disserta- (2, Fa) Design and applications of polymers, tion. Graded IP/CR/NC. liposomes, micro/nanoparticles, prodrugs, RSCI 521 Seminars in Regulatory Science and macromolecules for parenteral, oral, trans- (1, max 3, FaSpSm) Current problems in dermal, respiratory and CNS drug delivery. regulatory affairs, legal management, preclini- Pharmaceutical Sciences (PSCI) Recommended preparation: college level chem- cal and clinical testing, scientific evaluation istry and biology; prerequisite: PSCI 665. and quality assurance. (Duplicates credit in PSCI 531 Cell Biology (4) (Enroll in former MPTX 521.) Graded CR/NC. Recom- INTD 531) PSCI 664 Drug Discovery and Design (4, Fa) mended preparation: undergraduate degree in Principles of drug discovery, design and char- pharmacy, medical or independent health PSCI 561 Molecular Genetics (4, Sp) (Enroll acterization. Mechanisms of action of major sciences, engineering or equivalent mix of in INTD 561) classes of drugs. Recommended preparation: post secondary training and industry experi- ­college level chemistry and biology. ence; enrollment in M.S., Regulatory Science PSCI 571 Biochemistry (4, Fa) (Enroll in program. INTD 571) PSCI 665 Drug Transport and Delivery (4, Fa) Principles of cellular drug transport, RSCI 525 Introduction to Drug and Food PSCI 590 Directed Research (1-12, FaSpSm) in vivo drug transport, and modern drug Toxicology (3) Factors affecting toxic Research leading to the master’s degree. delivery, including drug targeting. Recom- responses to foods and drugs: dose-response Maximum units which may be applied to the mended preparation: college level chemistry relationships, absorption, distribution, degree to be determined by the department. and biology. biotransformation, elimination of toxicants; Graded CR/NC. target organ toxicity, teratogenesis, muta- PSCI 666 Molecular Structural Biology genesis, carcinogenesis, food allergies, risk PSCI 594abz Master’s Thesis (2-2-0, FaSp) (2, Sp) Molecular structure of proteins and assessment. Recommended preparation: under- Credit on acceptance of thesis. Graded DNA. Structure-function relationships and graduate degree in pharmacy, medical or IP/CR/NC. Prerequisite: completion of all structure determination. Recommended prepa- independent health sciences, engineering or required course work for the M.S. degree. ration: college­ level chemistry and biology. equivalent mix of post-secondary training and industry experience. PSCI 599 Special Topics (2-4, max 8, FaSp) PSCI 667 Intracellular Drug Delivery and Topics in advanced pharmaceutical sciences. Targeting (2, 2 years, Sp) Mechanisms of RSCI 527 Medical Product Safety (3) membrane trafficking and intracellular trans- Management of medical product safety PSCI 601 Molecular Biology of Gene Regu- port and the utilization of these mechanisms by manufacturers/suppliers including: safe lation (2, max 8) (Enroll in BIOC 601) in drug delivery and targeting. Recommended manufacturing, labeling, packaging; phar- preparation: college level chemistry and biol- macovigilance, field observations, complaint PSCI 652L Structure Activity Relationship ogy, INTD 531. handling; record-keeping, safety issues docu- and Drug Design (4, 2 years, Sp) Computer- mentation; crisis management/recalls. Recom- ized correlation of biological activities with PSCI 756ab Seminar in Pharmaceutical mended preparation: undergraduate degree in molecular structures and physico-chemical ­Sciences (1-1, FaSpSm) Review of current pharmacy, medical or independent health sci- properties of drugs and their applications in pharmaceutical and related research topics. ences, engineering or equivalent mix of post- designing new drugs. Lecture and laboratory. secondary training and industry experience. PSCI 790 Research (1-12, FaSpSm) Research leading to the doctorate. Maximum units which may be applied to the degree to be determined by the department. Graded CR/NC. 844 USC School of Pharmacy

RSCI 528 Safety in the Health Care Environ- RSCI 532 Early Stage Drug Development RSCI 604 Regulatory Strategy in Asia (4) ment (3) Regulatory expectations for health (3) Explores the activities involved in trans- Regulatory policy, standards and practices care facilities and services: JCAHO certi- forming an early drug or biological candidate in different Asian markets: product licens- fication, environmental risk management, to a drug approved for marketing by regula- ing, import/export management, materi- management of medical and medication tory authorities. Recommended preparation: als sourcing, quality systems compliance, errors, reduction of health hazards. Recom- undergraduate degree in pharmacy, medical reimbursement, prescribing practices. Travel mended preparation: undergraduate degree in or independent health sciences, engineering may be required. Prerequisite: MPTX 519; pharmacy, medical or independent health sci- or equivalent mix of post-secondary training recommended preparation: undergraduate or ences, engineering or equivalent mix of post- and industry experience; enrollment in M.S., professional degree in pharmacy, medical or secondary training and industry experience. Regulatory Science, Certificate in Preclinical independent health sciences, engineering or Drug Development. equivalent mix of post-secondary training and RSCI 529 Application of Risk Management industry experience. Tools and Techniques (2) Use of risk man- RSCI 601 Biomedical Commerce (4) Intro- agement tools in the medical products arena: duction to business principles appropriate RSCI 605 Managing Organizations and functional analysis, fault-tree analysis, failure to medical products, including: supply and Human Resources (3) Theory and practice of modes and effects analysis, HACCP and six demand, product entry-exit strategies, financ- personnel management, organizational struc- sigma methods. Recommended preparation: ing, reimbursement, marketing and pricing in ture and industrial relations in small, growing undergraduate degree in pharmacy, medical global marketplace. Recommended preparation: enterprises and large global companies typical or independent health sciences, engineering undergraduate degree in pharmacy, medical of pharmaceutical and medical device sectors. or equivalent mix of post-secondary training or independent health sciences, engineering Recommended preparation: undergraduate or and industry experience. or equivalent mix of post-secondary training professional degree in pharmacy, medical or and industry experience; enrollment in M.S., independent health sciences, engineering or RSCI 530 Translational Medicine: An Over- Regulatory Science. equivalent mix of post-secondary training and view (2) An overview of principles and industry experience. concepts underlying drug discovery and RSCI 603 Managing Complex Projects (3) development, including terminology of trans- Theory and methods to manage complex RSCI 608 Regulatory Strategy in Europe lational science. Recommended preparation: projects in medical products sectors; time- and the Americas (4) Regulatory strategy undergraduate degree in pharmacy, medical lines, intellectual property, security, contracts, in EU, Canada, Mexico and South America; or independent health sciences, engineering budgets, review activities, reports, elec- culture, health-care practices, reimburse- or equivalent mix of post-secondary training tronic tools, cross-cultural communication. ment, product registration, quality systems, and industry experience; enrollment in M.S., Recommended preparation: undergraduate or trade restrictions, import/export require- Regulatory Science, Certificate in Preclinical professional degree in pharmacy, medical or ments. Travel may be required. Recommended Drug Development. independent health sciences, engineering or preparation: undergraduate or professional equivalent mix of post-secondary training and degree in pharmacy, medical or independent RSCI 531 Drug Discovery (4) Examines the industry experience. health sciences, engineering or equivalent process of drug discovery from selection of mix of post-secondary training and industry disease and therapeutic target to characteriza- experience. tion and validation of lead drug candidates. Recommended preparation: undergraduate RSCI 794abcdz Doctoral Dissertation degree in pharmacy, medical or independent (2-2-2-2-0) Dissertation research required for health sciences, engineering or equivalent completion of doctoral degree in Regulatory mix of post-secondary training and industry Science. Graded IP/CR/NC. experience; enrollment in M.S., Regula- tory Science, Certificate in Preclinical Drug Development.