(12) United States Patent (10) Patent No.: US 8,509,879 B2 Durkin Et Al
US008509879B2 (12) United States Patent (10) Patent No.: US 8,509,879 B2 Durkin et al. (45) Date of Patent: Aug. 13, 2013 (54) APPARATUS AND METHOD FOR (56) References Cited WIDEFIELD FUNCTIONAL IMAGING (WIFI) USING INTEGRATED STRUCTURED U.S. PATENT DOCUMENTS LLUMINATION AND LASER SPECKLE 6,208.415 B1* 3/2001 De Boer et al. ............... 356,450 MAGING 2003/0002028 A1 1/2003 Rice et al. ....................... 356/39 2006, O155195 A1* 7, 2006 Maier et al. ........ ... 600,476 2006/0184043 A1* 8/2006 Tromberg et al. ..... ... 600,476 (75) Inventors: Anthony J. Durkin, Irvine, CA (US); 2006/0268241 A1* 11/2006 Watson et al. .................. 353/94 David Cuccia, Costa Mesa, CA (US); OTHER PUBLICATIONS Bruce J. Tromberg. Irvine, CA (US); Dunn, A. K. Simultaneous imaging of total cerebral hemoglobin Amaan Mazhar, Irvine, CA (US); concentration, oxygenation, and blood flow during functional acti Bernard Choi, Irvine, CA (US) vation, Optics Letters, vol. 28, 1 Jan 2003, pp. 28-30.* Briers, J.D., Laser Doppler, speckle, and related techniques for blood (73) Assignee: The Regents of the University of perfusion mapping and imaging. Physiological Measurement, 22 California, Oakland, CA (US) (2001), R35-R66.* MacKinnon, N., et al. Spectrally Programmable light engine for in (*) Notice: Subject to any disclaimer, the term of this vitro or in vivo molecular imaging and spectroscopy, Applied Optics, patent is extended or adjusted under 35 Apr. 10, 2005, vol. 44, No. 1 1. pp. 2033-2040.* U.S.C. 154(b) by 1294 days. Barlow, A.L., etal, Quantization of Widefield Fluorescence Imaging Using Structured Illumination and Image Analysis Software, Micros copy Research and Technique, 70: 76-84 (2007).* (21) Appl.
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