Research Article iMedPub Journals ARCHIVES OF CLINICAL MICROBIOLOGY 2017 http://www.imedpub.com ISSN 1989-8436 Vol. 8 No. 3:43 DOI: 10.4172/1989-8436.100043 A Severe Leptospira interrogans Serovar Wen Z1*, Liqiang L2*, Yuhai B1,Wei F2, Jiansong T1, Copenhageni Infection Diagnosed by Next- Rongrong Z1, Jiandong L2, Generation Sequencing and Treated with Yong D1, Na P2, Huijue J2, 2 1,2,3 Corticosteroids Xin L , Hui W , Jinmin M2#and Yingxia L1#” 1 Shenzhen Key Laboratory of Pathogen and Immunity, State key Discipline of Abstract Infectious Diseases, Shenzhen Third Introduction: Leptospirosis is a worldwide zoonotic disease, with variable severity People’s Hospital, Shenzhen, China 2 BGI Shenzhen, Shenzhen 518083, China and involvement of multiple organs. Severe leptospirosis is associated with high 3 Department of Zoology, University of morbidity and mortality rates, which poses a great threat to human health. Due to Oxford, Oxford, UK the limitation of traditional clinical and laboratory diagnosis methods, pathogens “* The first two authors contributed equally for many infectious diseases, including leptospirosis, remain unknown. Recently, to this work.” unbiased next generation sequencing (NGS) sheds light on the precise and rapid diagnosis of intractable infectious diseases, which is greatly beneficial to the prompt treatment and reliable prognosis. Corresponding author: Yingxia Liu Case presentation: A 35 year old male got a fever with rapid hepato-renal-pulmonary involvement after his travel to Hunan province, China. The manifestations initiated with a jaundice-hemorrhage clinical type, and then followed by the combination
[email protected] of jaundice-hemorrhage and diffuse hemorrhage (PDH) clinical types, along with liver, heart, muscle and pancreas involvement.