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The Number of 959 Microbial-Related Targets from Both TTD and OMIM

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The number of 959 microbial-related targets from both TTD and OMIM EGFR FGFR1 PDF CA2 CA4 LCK PDGFRA SRC SCD CA6 CA12 CA14 MAOB ABCB1 PIK3CG PDGFRB ACACB DPEP1 DHFR TOP1 D2R FASN ATP4A NMDAR1 CD20 PNLIP TSPO SCN5A TOP2 CYP2C9 FCERG PCAT BCR-ABI LTF NAC PDE4 CA NMDAR NAV PTGR HRA LTR GPCRB HER2 ALPPL2 5HT3R IMD68 ILVBL TLR4 IMD67 NLRC4 NOD2 MYD88 NAIP TLR2 NOD1 CF CASP1 ATG16L1 LAD TLR5 IL22 TLR9 LCN2 CFTR NLRP3 NFKB1 CAMP IMD51 IL17A IRAK4 TLR1 HIES1 HPS2 FPR1 HSD11B1 CASP4 PGLYRP1 STK4 IL17RA HECTD3 IBD1 EDAID1 CGDX SCN3 IBD10 LAD3 CFDD MVP1 C8A RAB1 IFNG ITGB2 SCARB1 MMP12 IRF8 IKBKB HIF1A IKBKG PGLYRP3 PGLYRP4 CASP12 XLA IMD50 IMD41 CVID1 IMD13 IMD23 IMD71 IMD64 CTNNB1 MMP9 LBP ELANE CXCR1 CD14 MET TNFRSF1A AHR DEFA5 ASNA1 NR1H3 FADD SCN10A IRAK3 HTRA2 IFNLR1 IRGM NEIL1 NEIL3 REG3G DOCK8 PFITS HMD CELIAC1 GSD1B ICAS SCNX SCIDX1 IMD47 HIGM2 HIGM3 SCN4 CVID3 IMD31C TIIAC IMD40 RFMN CVID13 MIRAGE HIES3 HIES4 SCN8 IMD66 IMD70 LPRS1 DNMT1 CX3CR1 TREM1 CFD SLC2A2 IL1B CBL PRKCE TF GARS1 DUSP1 SEPHS1 DJ1 RUVBL1 RIPK1 RIPK2 TRADD PADI4 IL27RA IL23A LGALS8 IL17F GFM2 ALPK1 MEFV NEIL2 DPH3 CEACAM3 NLRP6 PLEKHF1 ACOD1 INAVA DAR KIDAD VP C2D CGD4 CGD1 MKS1 PKU CDG2C CDG2F IMD61 IMD33 HIGM1 HIGM5 CRIE C5D CFHD EDAID2 IBD13 AGM6 LPRS5 AGM2 C1QD C3D CGD3 LEPD SCN5 IMD12 IMD15B IMD17 IMD19 IMD24 IMD36 SCN6 IMD55 PRAAS2 IMD57 IMD58 IMD72 T1D NAD CELIAC13 STAT3 CD44 IFNAR1 ART4 BMP5 CEACAM5 CLCN1 COL1A2 MLH1 S100A8 S100A9 IL10 DRD4 NCF4 SMO ATF3 NEDD8 COCH MTRNR1 ENG PDYN NR3C1 GFPT1 HOXB8 LYZ LAMA2 MPG MUC5AC IL12B NOS2 LEP AKT1 SPP1 PTAFR CD36 PTGER1 PTGER3 TYK2 PRKCD SLC6A4 MMP3 CD8A LEU2 MAP3K8 UGP2 UMOD CDH1 OTX1 EIF5A SCNN1A NR1H2 GBP1 DEFA6 CHUK SHH MUC5B SLC12A2 MSH3 SIM2 CD47 MAP2K2 SEMA3B PTCH1 CCR5 INPP5D KIN GSC2 GPR31 RAC2 NRP2 ADAM10 MRPL12 ATP8B1 PARK2 GP2 AP3B1 MBD4 TNFSF10 GPHN RNASEH1 SYT7 ACTR2 ATG5 SIRT2 CALCOCO2 MALT1 TBCE PGLS FOXP3 TLR7 TLR8 CYBB G6PD MVP LONP1 EIF5B SESN1 GRPEL1 DICER1 PRDX5 DCD GFM1 NAT8 PYCARD IFNL2 IFNL3 IFNL1 BPIFA1 ERAL1 MMAA MMAB PLVAP SESN2 PADI1 MARCHF4 LHX6 NEU1 MMP28 LACTB TIFA CARD8 MSH2 NDUFA13 NLRP12 MMACHC ITLN1 RNF167 PAH TET2 RAB32 TMEM189 G6PC3 MTRF1L MSRB2 BAHD1 PLD6 ERO1LB CLPX CST9 AGMAT ACE ADRB2 COMT BCL2 LEF1 VNN1 HDLCQ8 SPDA1 BPES DFNA1 SLE EDSCL1 EDSPD1 CMT2D AGM1 LSS MYHRS IGER DM1 PKD1 EPP1 DGS DGCR VCFS WHIMS WHS SCN1 IMD27A BESC1 CANDF2 CHS DFNB3 HMN5A SLEB1 TMAU CDG1B EV1 FBS CGD2 UFS1 CVID2 HRDS VICIS SIOD HIES2 KCS1 SGD1 MANSA MPOD NPHS1 SDS1 GSSD VKCFD1 XPA XLP2 MCLDS XMEN IMD74 BTHS IGHD3 THMD2 SPENCDI IMD73A CML C7D IMD25 FCAS2 IMD10 LPFS1 SCN2 CFID CGL4 CVID4 CVID5 CVID6 AGM3 AGM4 IMD31B PSORS14 C4BD C4AD WAS2 ARCI9 IMD18 IMD22 IMD37 TTD3 CANDF9 IMD44 RUSAT2 SGD2 NPHS14 IBD29 LPFS3 IMD69 IMD73B KILQS OIEDS2 CANDF1 IGAD1 PTOS1 CELIAC8 CELIAC10 APLDC3 ARCI7 ZWINTAS HIGM4 RFC1 AOAH ADK ADORA2A ADH5 GGTA1P ACY1 APP CD19 SERPINA1 IFNGR1 ARRB1 ARRB2 ACLY ATP6V0C LST1 BPI CEACAM1 CD80 CTSG CDC42 HSPD1 CGB COL6A1 CD46 ITGAM GJB2 CRYAA CRYAB CST1 CTPS1 CYP2C19 BCR ALOX5 SLC6A3 DAG1 RAG1 RAG2 RAD51 HAS1 PPARG CHI3L1 CHI3L2 RAD51AP1 DARS1 ART3 SMAD3 UBE1C HAO1 CNR2 WASL MRM2 GALE MTCO1 MTCO2 MTCO3 GDI1 SMS EDNRA FDPS FN1 ITGA5 ITGB1 FPR2 TSTA3 SLC6A1 GATA2 GCG GLP1 GCK SLC2A1 GLUL GLULL1 GPX1 GYS1 GLO1 CSF2 CXCL2 GNAI1 GNAO1 HP ACSM3 IMPDH1 IMPDHL1 FCGR3A IGLL1 CXCR2 FCER1G ITPA IRF1 IRF2 IL4 IL4R KRT16 LALBA LPO LAMA1 MIF YBX1 MBL2 MC1R MUC1 MUC7 NGF CD177 SNCA SLC6A2 CEACAM6 NFKB2 VAV1 TAP1 ALPI PGM3 SERPINB2 PLAUR PIGR POLG PRNP PRDX1 MAP2K1 RNASE1 POLR2B PI3 SLC5A1 SOX2 CD3G CD247 TXN CD1B CD1D TIMP3 GTF2E1 GTF2F1 TFRC TGFB1 TPP2 TPM1 TNFRSF1B NTRK1 UBB DPAGT1 PLAU OPRM1 CHIT1 EMX2 LRP2 SYK APOBEC1 PDCD1 PMS1 PMS2 SLC11A1 SLC1A2 XRCC2 RAD52 GBP2 ECE1 PCSK4 MASP1 IK IL15 STAT1 TFF3 MEF2A KCNJ2 LY9 TMBIM6 SCNN1B SCNN1G MR1 GCKR NCOR1 GFI1 IL18 GSS TJP1 CLPP IL1RL1 PTK2B MAP1LC3A TOP3A FCN1 MAP2K6 DDX1 GUCA2B SLC10A2 MAP2K4 HSD17B8 FCN2 ART1 HAS2 UBE2I PTEN SH3GL1 GNPDA1 METAP2 CX3CL1 TRAF3 CRY1 OGG1 GPR18 RAC1 TBX1 DEFB1 TRAPPC10 DIAPH1 COX10 HTRA1 DEFB4A ARVCF MAP2K3 TRAF6 GATM OPTN CISH MAP3K5 PTPNS1 TRDMT1 LGALS4 ACOT7 SLC22A18 NAALADL1 MYO15A SLC37A4 TNFRSF14 DDT DNMT3A DNMT3B RAD51D PDE1C SERF1A TLR3 ENSA ATP7A SLC27A5 NDUFA8 NAE1 CSDA DPH2 ASS1 NFS1 SMPD2 IFRD1 BCL10 DPH1 GABBR1 TOP3B MOCS1 QARS1 APOL1 COX7C SLC23A1 SLC23A2 FFAR2 NDUFB7 SUCLA2 SUCLG2 SLC5A6 ADAMTS13 DNAJB2 POLR2J RPL24 CXCL14 ARPC1B HACL1 ZRANB2 PLPBP GAB1 SIRT1 SIRT3 SIRT4 SIRT5 ZNF423 DNAJB1 AIM2 FCGR2B MRRF NIT1 HSPB3 WARS2 RUVBL2 PTGDR2 MARCO PCSK7 TBX21 MUTYH AIFM1 RAB9 BTK CFP WAS TAZ GK TAB3 BCOR SH2D1A BCORL1 GDPD2 LAMP2 PIGA PIGAP1 MTND1 MC1DM3 TAB2 ANKH PTGES TOR1A ADCY10 AICDA JPH2 NARF CD274 TLR6 MPHOSPH1 MPHOSPH6 MPHOSPH9 DNAJC2 MPHOSPH10 MAT2B NEU2 RAB11A RAB31 SPTLC2 JAM1 HEBP2 UNC13B SPON2 STIM1 GDE1 IL32 MRTFA SLC44A4 QPRT CLEC7A TLR10 TXNRD2 NLRP1 FXN COQ8A TFB1M TFB2M MTHFR REXO2 CARD9 CLINT1 LIPH STBD1 DISP1 PASK SARS1 KCNQ1 MSMO1 SLC25A21 ARSA ATM TICAM1 OSTM1 BEST1 PADI2 NFKBIZ SLC37A1 ACP33 PGLYRP2 UNC93B1 IL27 ECSIT MFN1 NCF1 GTPBP3 IL33 NMNAT1 FBXO3 HCAR2 TPSD1 SLC25A22 SLC25A18 MIR155 BIC HS3ST5 ERCC6 PGBD3 IL31 PLEKHM2 QTRT1 CLYBL PKLR PRDM9 SLC47A1 SLC47A2 ALDH5A1 TIMD4 ST6GALNAC2 TRMU PCGF1 METAP1D MOGAT2 LCMT1 SLC15A3 MIR27B FCGR3B PGPEP1 SLC25A31 POLN DNAJC24 DPH5 NARFL TRMT2A PIEZO1 THNSL1 DNAJB5 POLDIP2 NCR3 FARS2 POGLUT2 UBIAD1 NAALAD2 OTUD7B NHEDC2 KLRK1 IYD RRAGA FECH GBP7 METTL3 URM1 PUS10 NDUFAF3 FILIP1L UROC1 SLC39A8 RAB34 YARS2 TRMT5 SLC25A26 NLRC5 XPNPEP3 HFE PYGL ANAPC10 CCDC39 HMGCL DNAJC5B CGAS RNASE9 OLFM4 BPIFB2 BPIFC BPIFB6 RHBDF2 RASGEF1B CHAC1 MALSU1 SLFN12 SLFN12L IL17RE IFNE DEFB114 GMPPB SLC15A4 HRNR SLC39A11 LYG2 DAPK2 CERCAM MORC2 PIPOX GSDMD GUF1 TMEM59 HECW2 PRAG1 YBEY PCGF3 WFDC2 SFTA3 ATP5PD NECAB2 ASPG METTL15 CPQ ABCF3 TENT5B.
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    Supplementary Table S4. FGA Co-Expressed Gene List in LUAD

    Supplementary Table S4. FGA co-expressed gene list in LUAD tumors Symbol R Locus Description FGG 0.919 4q28 fibrinogen gamma chain FGL1 0.635 8p22 fibrinogen-like 1 SLC7A2 0.536 8p22 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 DUSP4 0.521 8p12-p11 dual specificity phosphatase 4 HAL 0.51 12q22-q24.1histidine ammonia-lyase PDE4D 0.499 5q12 phosphodiesterase 4D, cAMP-specific FURIN 0.497 15q26.1 furin (paired basic amino acid cleaving enzyme) CPS1 0.49 2q35 carbamoyl-phosphate synthase 1, mitochondrial TESC 0.478 12q24.22 tescalcin INHA 0.465 2q35 inhibin, alpha S100P 0.461 4p16 S100 calcium binding protein P VPS37A 0.447 8p22 vacuolar protein sorting 37 homolog A (S. cerevisiae) SLC16A14 0.447 2q36.3 solute carrier family 16, member 14 PPARGC1A 0.443 4p15.1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha SIK1 0.435 21q22.3 salt-inducible kinase 1 IRS2 0.434 13q34 insulin receptor substrate 2 RND1 0.433 12q12 Rho family GTPase 1 HGD 0.433 3q13.33 homogentisate 1,2-dioxygenase PTP4A1 0.432 6q12 protein tyrosine phosphatase type IVA, member 1 C8orf4 0.428 8p11.2 chromosome 8 open reading frame 4 DDC 0.427 7p12.2 dopa decarboxylase (aromatic L-amino acid decarboxylase) TACC2 0.427 10q26 transforming, acidic coiled-coil containing protein 2 MUC13 0.422 3q21.2 mucin 13, cell surface associated C5 0.412 9q33-q34 complement component 5 NR4A2 0.412 2q22-q23 nuclear receptor subfamily 4, group A, member 2 EYS 0.411 6q12 eyes shut homolog (Drosophila) GPX2 0.406 14q24.1 glutathione peroxidase
  • Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-Cov-2 Infection: What Can Be Learned from Other Coronaviruses

    Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-Cov-2 Infection: What Can Be Learned from Other Coronaviruses

    International Journal of Molecular Sciences Review Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses Morvarid Siri 1 , Sanaz Dastghaib 2 , Mozhdeh Zamani 1 , Nasim Rahmani-Kukia 3 , Kiarash Roustai Geraylow 4 , Shima Fakher 3, Fatemeh Keshvarzi 3, Parvaneh Mehrbod 5 , Mazaher Ahmadi 6 , Pooneh Mokarram 1,3,* , Kevin M. Coombs 7 and Saeid Ghavami 1,8,9,* 1 Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran; [email protected] (M.S.); [email protected] (M.Z.) 2 Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz 7193635899, Iran; [email protected] 3 Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran; [email protected] (N.R.-K.); [email protected] (S.F.); [email protected] (F.K.) 4 Student Research Committee, Semnan University of Medical Sciences, Semnan 3514799422, Iran; [email protected] 5 Influenza and Respiratory Viruses Department, Pasteur Institute of Iran, Tehran 1316943551, Iran; [email protected] 6 Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838695, Iran; [email protected] 7 Department of Medical Microbiology and Infectious Diseases, Rady Faculty of Health Sciences, Max Rady Citation: Siri, M.; Dastghaib, S.; College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; [email protected] Zamani, M.; Rahmani-Kukia, N.; 8 Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College Geraylow, K.R.; Fakher, S.; Keshvarzi, of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada F.; Mehrbod, P.; Ahmadi, M.; 9 Faculty of Medicine, Katowice School of Technology, 40-555 Katowice, Poland Mokarram, P.; et al.