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Sleep Disorders in Cervical Dystonia, Parkinson's Disease and Depression Southeastern European Medical Journal (SEEMEDJ) Published by University Josip Juraj Strossmayer Osijek Faculty of Medicine Osijek Editor-in-Chief Ines Drenjančević, MD, PhD, Osijek, Croatia Editorial Board Selma Uzunović, MD, PhD, Zenica, Bosnia and Herzegovina Dolores Biočina-Lukenda, MD, PhD, Split, Croatia Irena Drmić Hofman, MD, PhD, Split, Croatia Pavo Filaković, MD, PhD, Osijek, Croatia Ljubica Glavaš-Obrovac, MSc, PhD, Osijek, Croatia Nandu Goswami, MD, PhD, Graz, Austria Mitja Lainšćak, MD, PhD, Ljubljana, Slovenia Helena Lenasi, MD, PhD, Ljubljana, Slovenia Julian H. Lombard, PhD, Milwaukee, WI, USA Peter Nemeth, MD, PhD, Pécs, Hungary Shane A. Phillips, MSc, PhD, Chicago, Illinois, USA Rostyslav Stoika, PhD, Dr. Sci, Lviv, Ukraine Sandor G. Vari, MD, Los Angeles, CA, USA Aleksandar Včev, MD, PhD, Osijek, Croatia Oksana Zayachkivska, MD, PhD, DSc, Lviv, Ukraine George Wu, MD, PhD, Farmington, CT, USA Secretary: Marija Raguž, PhD English Language Proofreaders: AdHoc Cover: minimal.com.hr Technical Editors: minimal.com.hr Web page: minimal.com.hr Published online: http://seemedj.mefos.unios.hr ISSN 2459-9484 Contents Experimental Liver Peroxidation Against the Background of Limb Ischemia - Reperfusion Injury – Is There a Pathogenic Difference Between Its Modifications? .......................................... 1 Stature Estimation from the Right External Ear of Undergraduate Students in South-East Nigeria ......................................................................................................................................................................................... 12 Neoadjuvant Chemotherapy Affects TFF3 Peptide Expression in Luminal B Subtype of Breast Cancer – A Pilot Study ................................................................................................................................... 20 The Need for Systematic Monitoring and Improved Surveillance of Hepatitis C Patients in Croatia ................................................................................................................................................................................... 28 Sleep Disorders in Cervical Dystonia, Parkinson’s Disease and Depression – What is the Difference? ............................................................................................................................................................................... 35 The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients ...................................................................................................................................... 48 Percutaneous Laser Disc Decompression in the Treatment of Lumbar Radicular Pain 62 Validity of Neuroimaging in Juvenile Headaches ...................................................................................... 69 Characteristics of Thyroid Disease in Pediatric Population ................................................................. 77 Early Vital Indicators of Newborns Born After Medically Assisted Reproduction ............. 88 The Impact of Physical Activity and Sports on Academic Achievement of Students in Primary and Secondary Schools in Osijek-Baranja County, Croatia ............................................. 97 Pathohistological Diagnosis of Adrenal Tumors: Experience of a Single Center ............. 108 The Histopathological Findings of Operated Tumors of the Parathyroid Glands and Patient Data: A Single Centre Experience ....................................................................................................... 113 Croatian Translation and Linguistic Adaptation of the Short Assessment of Health Literacy for Spanish Adults (SAHLSA-50) ........................................................................................................ 121 A Study of Patient Satisfaction With Healthcare in Zenica-Doboj Canton ............................ 129 SEEMEDJ 2020, VOL 4, NO. 2 Liver Peroxidation and Limb Ischemia-Reperfusion Injury Original article Experimental Liver Peroxidation Against the Background of Limb Ischemia - Reperfusion Injury – Is There a Pathogenic Difference Between Its Modifications? 1 Nataliya V. Volotovska*1 1 Department of Physiology, Bioethics and Biosafety, I. Ya. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine *Corresponding author: Nataliya Volotovska, [email protected] Abstract Introduction: Use of the haemostatic tourniquet is an important step in providing first aid in open bleeding injuries. Tourniquet pressure on the extremity triggers local lipid peroxidation. However, the systemic influence of tourniquet thereof has not been fully studied. Aim: This study aimed to evaluate the changes that occur against the background of ischemia- reperfusion syndrome (IRS) and modifications of trauma in the main gland for detoxification – the liver. Material and Methods: In order to estimate the liver condition under the effects of a haemostatic tourniquet, animals were divided into five experimental groups, where modifications of hypoxia were performed as a result of bleeding, IRS and trauma due to mechanical fracture of the thigh. Results: Biochemical study of the liver has shown that each type of such interventions caused the activation of lipid peroxidation in this organ. The highest increase of the malonic dialdehyde rate was observed in response to haemostatic tourniquet combined with blood loss. Additionally, its content was higher in the group combining mechanical trauma and the tourniquet compared to isolated trauma. Conclusion: All types of interventions caused hypoxia – as a result of isolated bleeding and cessation of blood flow due to the tourniquet. However, the release of overconcentration of toxic derivatives of rhabdomyolysis, which entered the blood stream after limb release, activated the pathological mechanisms of IRS, which included intensified lipid peroxidation in the liver. (Volotovska N. Experimental Liver Peroxidation Against the Background of Limb Ischemia - Reperfusion Injury – Is There a Pathogenic Difference Between Its Modifications? SEEMEDJ 2020; 4(2); 1-11) Received: Feb 29, 2020; revised version accepted: Jul 30, 2020; published: Nov 12, 2020 KEYWORDS: ischemia-reperfusion syndrome, liver, blood loss, tourniquet, lipid peroxidation 1 Southeastern European Medical Journal, 2020; 4(2) SEEMEDJ 2020, VOL 4, NO. 2 Liver Peroxidation and Limb Ischemia-Reperfusion Injury anaesthesia (40 mg/kg of body weight Introduction intraperitoneally); EG1 (rubber tourniquet was applied to the upper third of the thigh for 2 hours, Nowadays, as in the past, the use of the reperfusion lasted 1 hour (isolated IRS); EG2 haemostatic tourniquet is an important step in (simulated blood loss in the amount of 40% of providing first aid [1, 2]. However, a careful study the volume of circulating blood from the femoral of the mechanisms of ischemia-reperfusion vein); EG3 (tourniquet on thigh was combined syndrome due to the use of haemostatic with 40% blood loss from the femoral vein on the bandage is required [3]. The latter was proved to other lower limb), EG4 (mechanical trauma that be an important cause of oxidative stress [4, 5], caused fracture of femur), EG5 (tourniquet on which promotes lipid peroxidation in the limb thigh was combined with fracture of femur of the region under tourniquet pressure, and affects other lower limb). Given the onset of severe pain metabolism and protective reactions in the in EG4 and EG5, an injection of a 2%-solution of entire organism [6, 7]. lidocaine was administered for 7 days in the posttraumatic period. Animals in other groups The essence of ischemia-reperfusion syndrome were administered analgesics twice – on the day (IRS) is that after the release of the tourniquet, a of intervention and on the following day. large amount of toxins enters systemic blood circulation [8, 9], which, in turn, causes an The experiments were performed in the increase in functional liver activity [10-13]. vivarium of I. Horbachevsky TNMU in the However, against the background of hypemic morning. The special room had a stable hypoxia, full liver repair is impossible. At the temperature (18-22 ºC), relative humidity (40- moment, there is not enough data that could 60%) and illumination of 250 lux. comprehensively explain the correlation All experimental stages of work were performed between the IRS and the liver, especially lipid in accordance with the European Convention for peroxidation (LPO) in the liver in the condition of the Protection of Vertebrate Animals Used for IRS Experimental and Other Scientific Purposes (Strasbourg, 1986), the resolution of the First Material and Methods National Congress on Bioethics (Kyiv, 2001) and the Order of the Ministry of Health of the Ukraine The experiments were performed on 260 white No. 690 of 23 September 2009. non-linear male rats 5-5.5 months old. The animals were removed from the experiment at The activity of active thiobarbituric acid the 1st hour after intervention, and on the 1st, 3rd, derivatives in 10% of liver homogenate samples 7th and 14th day after trauma on the basis of was determined using a method based on the thiopental-sodium anaesthesia (40 mg/kg of ability of secondary products of lipid body weight intraperitoneal) by total bleeding peroxidation (LPO), especially malonic from the heart. Such number was based on the dialdehyde, during a reaction with thiobarbituric need to obtain statistically significant data in acid at high temperatures
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