bioRxiv preprint doi: https://doi.org/10.1101/852673; this version posted December 2, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Title: Massively parallel disruption of enhancers active during human corticogenesis Authors: Evan Geller1, Jake Gockley1§, Deena Emera1‡, Severin Uebbing1, Justin Cotney1+, James P. Noonan1,2,3* Affiliations: 1. Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA. 2. Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. 3. Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA §Present address: Sage Bionetworks, Seattle, WA 98121, USA. +Present address: Department of Genetics and Genome Science, University of Connecticut Health, Farmington, CT 06030, USA ‡Present address: Center for Female Reproductive Longevity and Equality, Buck Institute for Research on Aging, Novato, CA 94945, USA *Corresponding author:
[email protected]. bioRxiv preprint doi: https://doi.org/10.1101/852673; this version posted December 2, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Abstract: Changes in gene regulation have been linked to the expansion of the human cerebral cortex and to neurodevelopmental disorders. However, the biological effects of genetic variation within developmental regulatory elements on human corticogenesis are not well understood.