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THOMAS JEFFERSON SHARPTON Department of Microbiology [email protected] Oregon State University lab.sharpton.org 226 Nash Hall, Corvallis, OR 97331 @tjsharpton tel: (541) 737-8623 fax: (541) 737-0496 github.com/sharpton EDUCATION 2009 University of California, Berkeley, CA Ph.D., Microbiology, Designated Emphasis in Computational Biology 2003 Oregon State University, Corvallis, OR B.S. (Cum Laude), Biochemistry and Biophysics. APPOINTMENTS 2013- Assistant Professor Departments of Microbiology and Statistics, Oregon State University 2009-2013 Bioinformatics Fellow Gladstone Institute of Cardiovascular Disease, Gladstone Institutes Mentors: Katherine Pollard & Jonathan Eisen (UC Davis) 2003-2009 Graduate Student Researcher Department of Microbiology, University of California, Berkeley Mentors: John Taylor & Sandrine Dudoit 2005 Bioinformatics Research Intern The Broad Institute Mentor: James Galagan 2002-2003 Research Assistant Department of Zoology, Oregon State University 2001 Research Assistant International Arctic Research Center, University of Alaska, Fairbanks, AK HONORS & AWARDS 2013 Gladstone Scientific Leadership Award 2007 Dean’s Council Student Research Representative 2007 Effectiveness in Teaching Award, UC Berkeley 2006-2008 Chang-Lin Tien Graduate Research Fellowship 2002 Student Leadership Fellowship 2002 HHMI Undergraduate Research Fellowship 2002-2003 Dr. Donald MacDonald Excellence in Science Scholarship 2002 OSU College of Science's Excellence in Science Scholarship 1999-2003 Provost Scholarship 1999 American Legion Student Ethics Award PUBLICATIONS Refereed Journal Articles 17. O’Dwyer JP, Kembel SW, Sharpton TJ (In Review) Backbones of Evolutionary History Test Biodiversity Theory for Microbes 16. Quandt AC, Kohler A, Hesse C, Sharpton TJ, Martin F, Spatafora JW. (In Print) Metagenomic sequence of Elaphomyces granulatus from sporocarp tissue reveals Ascomycota ectomycorrhizal fingerprints of genome expansion and a Proteobacteria rich microbiome. Environmental Microbiology. 15. Skewes-Cox P, Sharpton TJ, Pollard KS, DeRisi JL. (2014) Profile hidden Markov models for the detection of viruses within metagenomic sequence data. PLOS ONE 9(8): e105067. 14. Kent M, Soderlund K, Thomann E, Schreck CB, Sharpton TJ. (2014) Post-mortem sporulation of Ceratomyxa Shasta (Myxozoa) after dealth in adult Chinook salmon. Journal of Parasitology. Published online April 11, 2014. [PMCID – In progress]. 13. Sharpton TJ^. (2014) An Introduction to the Analysis of Shotgun Metagenomic Data Frontiers in Plant Genetics and Genomics. 5(209) PMCID: PMC4059276. 12. Kidd JM*, Sharpton TJ*, Norman PJ, Carpenter M, Sikora M, Gignoux CR, Gorgani NN, Agilent Technologies, Pollard KS, Parham P, Feldman MW, Wall J, Bustamante CD, Henn BM. (2014) Exome Capture from Saliva Produces High Quality Genomic and Metagenomic Data. BMC Genomics. 15(262). PMCID: PMC4051168 11. Finucane M, Sharpton TJ, Laurant T, Pollard KS (2014) A taxonomic signature of obesity in the microbiome? Getting to the guts of the matter PLOS ONE. 9(1): e84689. PMCID: PMC3885756 10. Ladau J, Sharpton TJ, Jospin G, Kembel SW, O'Dwyer JP, Koeppel A, Green JL, Pollard KS. (2013) Global marine bacterial diversity peaks at high latitudes in winter. International Society of Microbial Ecology Journal. Published online March 21, 2013; DOI: 10.1038/ismej.2013.37. PMCID: PMC3749493 9. Sharpton TJ*^, Jospin G*, Wu D, Langille MG, Pollard KS, Eisen JA (2012). Sifting through genomes with iterative-sequence clustering produces a large, phylogenetically diverse protein-family resource, BMC Bioinformatics, 13(1): 264. PMCID: PMC3481395 8. Whiston E, Wise HZ, Jui G, Sharpton TJ, Cole GT, Taylor JW. (2012) “Comparative Transcriptomics of the Saprobic and Parasitic Growth Phases in Coccidioides spp.” PLOS ONE. 7(7): e41034. PMCID: PMC3401177 7. Wylie KM, Truty RM, Sharpton TJ, Mihindukulasuriya KA, Zhou Y, Gao H, Sodergren E, Weinstock GM, Pollard KS (2012). Novel bacterial taxa in the human microbiome, PLOS ONE, 7(6): e3529. PMCID: PMC3374617 6. The Human Microbiome Project Consortium (2012) A Framework for Human Microbiome Research, Nature, 486: 215–221. PMCID: PMC3377744 5. The Human Microbiome Project Consortium (2012). Structure, function and diversity of the human microbiome in an adult reference population, Nature, 486: 207-214. PMCID: PMC3564958 4. Sharpton TJ^, Riesenfeld SJ, Kembel SW, Ladau J, O'Dwyer JP, Green JL, Eisen JA, Pollard KS (2011). PhylOTU: a high-throughput procedure quantifies microbial community diversity and resolves novel taxa from metagenomic data, PLOS Computational Biology, 7(1): e1001061. PMCID: PMC3024254 3. Neafsey DE, Barker BM, Sharpton TJ, Stajich JE, Park D, Whiston E, Hung C, McMahan C, White J, Sykes S, Heiman D, Young S, Zeng Q, Abouelleil A, Aftuck L, Bessette D, Brown A, FitzGerald M, Lui A, Macdonald JP, Priest M, Orbach MJ, Galgiani JN, Kirkland TN, Cole GT, Birren BW, Henn MR, Taylor JW, Rounsley SD. (2010) Population Genomic Sequencing of Coccidioides Fungi Reveals Recent Hybridation and Transposon Control, Genome Research, 20: 938–946. PMCID: PMC2892095 2. Sharpton TJ^, Stajich JE, Rounsley SD, Gardner MJ, Wortman JR, Jordar VS, Maiti R, Kodira CD, Neafsey DE, Zeng Q, Hung C, McMahan C, Muszewksa A, Grynberg M, Mandel MA, Kellner EM, Barker BM, Galgiani JN, Orbach MJ, Kirkland TN, Cole GT, Henn MR, Birren BW, Taylor JW. (2009) Comparative Genomic Analyses of the Human Fungal Pathogens Coccidioides and their Relatives, Genome Research, 19: 1722– 1731. PMCID: PMC2765278 1. Sharpton TJ^, Neafsey DE, Galagan JE, and Taylor JW. (2008) Mechanisms of Intron Gain and Loss in Cryptococcus, Genome Biology, 9(1): R24. PMCID: PMC2395259 *Indicates co-first author ^Indicates corresponding author Other Publications Sharpton TJ, Jhaveri AA. (2006) Leveraging the Knowledge of Our Peers: Online Communities Hold the Promise to Enhace Scientific Research. PLOS Biology, 4(6): e199. PROFESSIONAL MEMBERSHIP & SERVICE ACADEMIC SERVICE 2014- Committee Member. Microbiology Graduate Admissions, OSU 2014- Committee Member. (Under)graduate Bioinformatics Curriculum Task Force, OSU 2014- Subcommittee Co-Chair. Graduate Bioinformatics Curriculum Task Force, OSU 2014- Review Editor. Frontiers in Systems Microbiology 2013-2014 Committee Member. Center for Genome Research and Biocomputing Spring Colloquium Steering Committee, OSU 2013- Biological Consultant. Informal advisor for statisticians, OSU 2013- Statistical Consultant. Informal advisor for microbiologists, OSU 2010- Member. The Human Microbiome Project Consortium 2009- Journal Referee. Science, PLoS Computational Biology, BMC Genomics, Molecular Ecology, FEMS Microbial Ecology, Microbiome, Bioinformatics, PLoS ONE 2010 Advisor. UCSF Biomedical Informatics Graduate Program Review 2007 President. Plant and Microbial Graduate Group, UC Berkeley 2007 President. Microbiology Student Group, UC Berkeley 2006 Chair. Microbiology Student Symposium, UC Berkeley 2006-2008 Webmaster. Microbiology Student Group, UC Berkeley 2005 Reviewer. Joint Genome Institute’s IUMS Genome Browser Review TEACHING AND TRAINING Academic Courses 2014 Introduction to Quantitative Genomics. ST599 Course Developer and Instructor (Fall Quarter) 2014 Molecular Host-Microbe Interactions. MCB637 Guest Lecture – “The Human Gut Microbiome” (5/30) 2014 Microbial Bioinformatics and Genome Evolution. OSU MB668 Course Developer and Lead Instructor. (Spring Quarter) 2014 Neuroendrocrine Regulation of Energy Metabolism. OSU NUTR 599/699 Guest Lecture – “The Human Gut Microbiome” (4/14) 2014 Nucleic Acid Bioinformatics. OSU BB499/599 CS419/519 Guest Lecture – “Inferring functional elements from conservation” (2/17) 2013 Microbial Systems. OSU MB511 Guest Lecture - “Mapping the Diversity of Marine Bacteria” (11/25) 2013 Microbiomes and Host-Microbiome Interactions. OSU HC407 Guest Lecture - “The Human Gut Microbiome” (11/12) 2007 Comparative Genomics Seminar UC Berkeley PMB290 Course Organizer 2006 The Diversity of Fungi. UC Berkeley PMB110 Graduate Student Assistant Instructor 2004 Introduction to Biology. UC Berkeley BIO1B Graduate Student Assistant Instructor 2003 Cell and Molecular Biology. OSU BI314 Undergraduate Student Assistant Instructor ADVISING 2014- Melissa Conley, PhD Co-Advisor, Nutrition 2014 Martin Guyer. MS Co-Advisor, Statistics 2014- Nicole Kirchoff, PhD Advisor, Microbiology 2014- Christopher Gaulke, Postdoctoral Fellow, Microbiology 2014- Kyle Duyck, Undergraduate Researcher, Biochemistry/Biophysics 2014- Holman Jue, Undergraduate Researcher, Microbiology 2014- Sean McNall, Undergraduate Researcher, Microbiology 2014 Courtney Armour, Rotation Student, MCB MENTORSHIP: INFORMAL 2013 Dr. Mariel Finucane – The obesity-associated gut microbiome 2013 Timothy Laurent – Ascertaining protein family quality and function 2012 Rachel Radnor – Computational analysis of marine microbial diversity 2012 Guillaume Jospin – Iterative clustering to identify novel proteins 2012 Stephen Nayfach – Assessing microbial functional diversity estimations 2011 Peter Skews-Cox – Building Viral HMMs for metagenomic data analysis 2011 Aram Avila-Herrera – Identification of CRISPRs in metagenomic data 2010 Dr. Rebecca Truty – Quantifying novel human microbiota THESIS/DISSERTATION COMMITTEE MEMBER AND SERVICE 2014- Trevor Tivey, Dept. Integrative Biology, PhD Committee Member 2014- Kimberly Kenny, Honors Thesis Committee Member 2014 Krista Soderlund, Honors Thesis Committee Member 2014 Martin Guyer, Dept. Statistics, MS Committee Member 2014- Edward Davis, Dept. Botany