Alizarin Datasheet | Buy Alizarin from Supplier Selleckchem.Com

08/01/13 Alizarin Datasheet | Buy Alizarin from supplier Selleckchem.com

Alizarin Datasheet

Technical Data Alizarin Chemical Structure

Molecular Weight (MW) 240.21 DMSO 48 mg/mL

Solubility (25°C) Water <1 mg/mL Formula C14H8O4 Ethanol <1 mg/mL

CAS No. 72-48-0 2 years -20°C Powder Return Policy Storage 2 weeks 4°C in DMSO Rubia, alizarin crimson, crimson Synonyms Selleck Chemicals wishes you the best madder, rose madder 6 months -80°C in DMSO possible online shopping experience with our 365 day unconditional Return Biological Activity Policy. If you are not satisfied with your purchase, either for protocol related or Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and product related problems, you may Description 2.7 μM, respectively. return any item(s) within 365 days from the original purchase date. Please see Targets CYP1A1 CYP1A2 CYP1B1 the following instructions when you return products. IC50 6.2 μM 10.0 μM 2.7 μM [1] 1. All requests for returns should be Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 communicated to Selleck Chemicals with K of 0.5 μM. Alizarin deduces the mutagenicity of MeIQx, which induced by each CYP1A2 or i prior to shipping. Any items returned to [1] In vitro CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits Selleck Chemicals should be in the antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid original packaging and in the same peroxidation in rat liver microsomes. [2] condition as originally purchased. 2. When returning purchased goods, Alizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level In vivo please inform us of the purchase order [2] of alanine aminotransferase in poisoned animals. number or package tracking number. Clinical Trials 3. Return shipping is absolutely FREE. 4. This offer is only valid for products Features purchased directly from Selleck and its authorized distributors. Protocol (Only for Reference) 5. Once your return request is received and approved, your refund will be [1] Kinase Assay: processed or automatically applied to Enzyme activities are measured by fluorometric quantification of each metabolite produced by O- your credit card within 7 days. Please deethylation of 7-ethoxycoumarin by CYP1A1 and CYP1B1, O-deethylation of 7-ethoxyresorufin by CYP1A2 note that depending on your credit card and 7-hydroxylation of coumarin by CYP2A6, using Hitachi F-2000 fluorescence spectrophotometer. The company, it may take additional 2-10 fluorescence of metabolite is not influenced by the presence of anthraquinone pigments at the doses business days for us to post the refund tested in these experiments. 7-Ethoxycoumarin is used at 40 μM for CYP1A1 and at 20 μM for CYP1B1. In to your account. the cases of CYP2C19, CYP2E1, CYP3A4 and CYP3A5, the amount of each metabolite derived from the catalytic reaction by individual CYPs is determined by HPLC equipped with a UV detector. The activities of Toll Free: CYP2C19 and CYP2E1 are determined by 4′-hydroxylation of (S)-mephenytoin and by 6-hydroxylation of (877) 796-6397 Measurement of chlorzoxazone, respectively. In the case of CYP3As, their activities are determined by 1′-hydroxylation of enzyme activities midazolam with a modification in which the metabolites are extracted from the incubation mixture before -- USA and Canada only -- of CYPs injection to HPLC. Briefly, 1 μM diazepam is added to the reaction mixture as an internal standard with an Fax: excess amount of ammonium sulfate and 5 volumes of ethyl acetate immediately after the incubation. After shaking for 10 min, 1′-hydroxymidazolam and diazepam are extracted into the ethyl acetate layer by +1-713-796-9816 centrifugation at 2000×g for 10 min, at 4 °C. Then ethyl acetate is removed by evaporation and the residue is used for HPLC after dissolving in methanol. A volume of 20 μM of midazolam is used for the detection of Orders: CYP3A4 activity and 7 μM for CYP3A5. To evaluate the K value of CYP1B1, the measurement of activity is m +1-832-582-8158 carried out at substrate doses from 2.5 to 40 μM. Ki value of Alizarin against the activity of CYP1B1 is [email protected] calculated from the enzyme activities in the presence of 0.2-1.6 μM Alizarin.

References Tech Support: [1] Takahashi E, et al. Mutat Res, 2002, 508(1-2), 147-156. +1-832-582-8158 [2] Zhang J, et al. J Nutr Environ Med, 1997, 7(2), 79-89. Ext:3 Monday–Friday PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE. 9:00 AM–5:00 PM (Central Time) [email protected] NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE We will contact you within one business day

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