DOCSLIB.ORG

Alizarin Datasheet | Buy Alizarin from Supplier Selleckchem.Com

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Alizarin Datasheet | Buy Alizarin from Supplier Selleckchem.Com 08/01/13 Alizarin Datasheet | Buy Alizarin from supplier Selleckchem.com Alizarin Datasheet Technical Data Alizarin Chemical Structure Molecular Weight (MW) 240.21 DMSO 48 mg/mL Solubility (25°C) Water <1 mg/mL Formula C14H8O4 Ethanol <1 mg/mL CAS No. 72-48-0 2 years -20°C Powder Return Policy Storage 2 weeks 4°C in DMSO Rubia, alizarin crimson, crimson Synonyms Selleck Chemicals wishes you the best madder, rose madder 6 months -80°C in DMSO possible online shopping experience with our 365 day unconditional Return Biological Activity Policy. If you are not satisfied with your purchase, either for protocol related or Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and product related problems, you may Description 2.7 μM, respectively. return any item(s) within 365 days from the original purchase date. Please see Targets CYP1A1 CYP1A2 CYP1B1 the following instructions when you return products. IC50 6.2 μM 10.0 μM 2.7 μM [1] 1. All requests for returns should be Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 communicated to Selleck Chemicals with K of 0.5 μM. Alizarin deduces the mutagenicity of MeIQx, which induced by each CYP1A2 or i prior to shipping. Any items returned to [1] In vitro CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits Selleck Chemicals should be in the antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid original packaging and in the same peroxidation in rat liver microsomes. [2] condition as originally purchased. 2. When returning purchased goods, Alizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level In vivo please inform us of the purchase order [2] of alanine aminotransferase in poisoned animals. number or package tracking number. Clinical Trials 3. Return shipping is absolutely FREE. 4. This offer is only valid for products Features purchased directly from Selleck and its authorized distributors. Protocol (Only for Reference) 5. Once your return request is received and approved, your refund will be [1] Kinase Assay: processed or automatically applied to Enzyme activities are measured by fluorometric quantification of each metabolite produced by O- your credit card within 7 days. Please deethylation of 7-ethoxycoumarin by CYP1A1 and CYP1B1, O-deethylation of 7-ethoxyresorufin by CYP1A2 note that depending on your credit card and 7-hydroxylation of coumarin by CYP2A6, using Hitachi F-2000 fluorescence spectrophotometer. The company, it may take additional 2-10 fluorescence of metabolite is not influenced by the presence of anthraquinone pigments at the doses business days for us to post the refund tested in these experiments. 7-Ethoxycoumarin is used at 40 μM for CYP1A1 and at 20 μM for CYP1B1. In to your account. the cases of CYP2C19, CYP2E1, CYP3A4 and CYP3A5, the amount of each metabolite derived from the catalytic reaction by individual CYPs is determined by HPLC equipped with a UV detector. The activities of Toll Free: CYP2C19 and CYP2E1 are determined by 4′-hydroxylation of (S)-mephenytoin and by 6-hydroxylation of (877) 796-6397 Measurement of chlorzoxazone, respectively. In the case of CYP3As, their activities are determined by 1′-hydroxylation of enzyme activities midazolam with a modification in which the metabolites are extracted from the incubation mixture before -- USA and Canada only -- of CYPs injection to HPLC. Briefly, 1 μM diazepam is added to the reaction mixture as an internal standard with an Fax: excess amount of ammonium sulfate and 5 volumes of ethyl acetate immediately after the incubation. After shaking for 10 min, 1′-hydroxymidazolam and diazepam are extracted into the ethyl acetate layer by +1-713-796-9816 centrifugation at 2000×g for 10 min, at 4 °C. Then ethyl acetate is removed by evaporation and the residue is used for HPLC after dissolving in methanol. A volume of 20 μM of midazolam is used for the detection of Orders: CYP3A4 activity and 7 μM for CYP3A5. To evaluate the K value of CYP1B1, the measurement of activity is m +1-832-582-8158 carried out at substrate doses from 2.5 to 40 μM. Ki value of Alizarin against the activity of CYP1B1 is [email protected] calculated from the enzyme activities in the presence of 0.2-1.6 μM Alizarin. References Tech Support: [1] Takahashi E, et al. Mutat Res, 2002, 508(1-2), 147-156. +1-832-582-8158 [2] Zhang J, et al. J Nutr Environ Med, 1997, 7(2), 79-89. Ext:3 Monday–Friday PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE. 9:00 AM–5:00 PM (Central Time) [email protected] NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE We will contact you within one business day Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under Website: the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. www.selleckchem.com Many products are stable in the short-term at temperatures that differ from that required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality, but save your shipping charges by using the most economical storage conditions for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product datasheet. www.selleckchem.com/datasheet/Alizarin-DataSheet.html 1/1.
Load more

Recommended publications
  • New Facile and Sensitive Methods for the Estimation of Telmisatran Y
    J. Curr. Chem. Pharm. Sc.: 4(1), 2014, 30-33 ISSN 2277-2871 NEW FACILE AND SENSITIVE METHODS FOR THE ESTIMATION OF TELMISATRAN Y. KRANTI KUMAR, K. VANITHA PRAKASH* and GUTHI LAVANYA Department of Pharmaceutical Analysis, SSJ College of Pharmacy, V. N. Pally, Gandipet, HYDERABAD – 500075 (A.P.) INDIA (Received : 26.10.2013; Accepted : 03.11.2013) ABSTRACT Two simple, accurate, rapid and sensitive Methods (A and B) have been developed for the estimation of Telmisatran in its pharmaceutical dosage form. The method A is based on the formation of yellow colored chromogen, due to reaction of Telmisatran with Alizarin red dye. The formation of ion association complexes of the drug with dyes in acidic phthalate buffer of pH 2.8 was followed by their extraction in chloroform, which exhibits λmax at 423 nm. The method B is based on the formation of golden yellow colored chromogen due to reaction of Telmisatran with Bromophenol blue dye. The formation of ion association complexes of the drug with dyes in acidic phthalate buffer of pH 2.8 was followed by their extraction in chloroform, which exhibits λmax at 416 nm. The absorbance-concentration plot is linear over the range of 100- 150 mcg/mL for method A and 20-50 mcg/mL for method B. Results of analysis for all the methods were validated statistically and by recovery studies. The proposed methods are precise, accurate, economical and sensitive for the estimation of Telmisatran in bulk drug and in its tablet dosage form. Key words: Telmisatran, Alizarin red, Bromophenol blue. INTRODUCTION Telmisartan is an angiotensin II receptor antagonist used in the management of hypertension.
    [Show full text]
  • Separation of Hydroxyanthraquinones by Chromatography
    Separation of hydroxyanthraquinones by chromatography B. RITTICH and M. ŠIMEK* Research Institute of Animal Nutrition, 691 23 Pohořelice Received 6 May 1975 Accepted for publication 25 August 1975 Chromatographic properties of hydroxyanthraquinones have been examined. Good separation was achieved using new solvent systems for paper and thin-layer chromatography on common and impregnated chromatographic support materials. Commercial reagents were analyzed by the newly-developed procedures. Было изучено хроматографическое поведение гидроксиантрахинонов. Хорошее разделение было достигнуто при использовании предложенных новых хроматографических систем: бумажная хроматография смесью уксусной кислоты и воды на простой бумаге или бумаге импрегнированной оливковым мас­ лом, тонкослойная хроматография на целлюлозе импрегнированной диметилфор- мамидом и на силикагеле без или с импрегнацией щавелевой или борной кислотами. Anthraquinones constitute an important class of organic substances. They are produced industrially as dyes [1] and occur also in natural products [2]. The fact that some hydroxyanthraquinones react with metal cations to give colour chelates has been utilized in analytical chemistry [3]. Anthraquinone and its derivatives can be determined spectrophotometrically [4—6] and by polarography [4]. The determination of anthraquinones is frequently preceded by a chromatographic separation the purpose of which is to prepare a chemically pure substance. For chromatographic separation of anthraquinone derivatives common paper [7—9] and paper impregnated with dimethylformamide or 1-bromonaphthalene has been used [10, 11]. Dyes derived from anthraquinone have also been chromatographed on thin layers of cellulose containing 10% of acetylcellulose [12]. Thin-layer chromatography on silica gel has been applied in the separation of dihydroxyanthraquinones [13], di- and trihydroxycarbox- ylic acids of anthraquinones [14] and anthraquinones occurring in nature [15].
    [Show full text]
  • Redalyc.JEAN-JACQUES COLIN
    Revista CENIC. Ciencias Biológicas ISSN: 0253-5688 [email protected] Centro Nacional de Investigaciones Científicas Cuba Wisniak, Jaime JEAN-JACQUES COLIN Revista CENIC. Ciencias Biológicas, vol. 48, núm. 3, septiembre-diciembre, 2017, pp. 112 -120 Centro Nacional de Investigaciones Científicas Ciudad de La Habana, Cuba Available in: http://www.redalyc.org/articulo.oa?id=181253610001 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative Revista CENIC Ciencias Biológicas, Vol. 48, No. 3, pp. 112-120, septiembre-diciembre, 2017. JEAN-JACQUES COLIN Jaime Wisniak Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel 84105 [email protected] Recibido: 12 de enero de 2017. Aceptado: 4 de mayo de 2017. Palabras clave: almidón-yodo, fermentación, fisiología vegetal, índigo, jabón, respiración de plantas, yodo. Key words: fermentation, iodine, indigo, plant physiology, plant respiration, soap, starch-iodine. RESUMEN. Jean-Jacques Colin (1784-1865), químico francés que realizó estudios fundamentales acerca de la fisiología de plantas, en particular germinación y respiración; el fenómeno de la fermentación, y la química del yodo durante la cual descubrió junto con Gaultier de Claubry, que el yodo era un excelente reactivo para determinar la presencia de almidón aun en pequeñas cantidades. Estudió también el efecto de diversas variables en la fabricación del índigo y jabones de diversas naturalezas. ABSTRACT. Jean-Jacques Colin (1784-1865), a French chemist, who carried fundamental research on plant physiology, particularly germination and fermentation; the phenomenon of fermentation and the chemistry of iodine, during which he discovered, together with Gaultier de Claubry, the ability of iodine to detect starch even in very small amounts.
    [Show full text]
  • Ashnagar 1.Pmd
    Biosciences, Biotechnology Research Asia Vol. 4(1), 19-22 (2007) Isolation and identification of 1,2-dihydroxy-9,10- anthraquinone (Alizarin) from the roots of Maddar plant (Rubia tinctorum) A. ASHNAGAR¹*, N. GHARIB NASERI² and A. SAFARIAN ZADEH¹ ¹School of Pharmacy, Ahwaz Jundi Shapour Univ. of Medical Sciences, Ahwaz (Iran) ²Ahwaz Faculty of Petroleum Engineering, Petroleum University of Technology, Ahwaz (Iran) (Received: March 02, 2007; Accepted: April 03, 2007) ABSTRACT The roots of madder (Rubia tinctorum) are source of anthraquinone dyes with alizarin being the main component. Free alizarin (I) is present in madder root in only small quantities, most of it is present as its glycoside i.e. ruberythric acid(III) On the basis of the importance of alizarin, in this research, it was isolated, purified and its structure was confirmed by various spectra. Maceration of the powdered madder roots in various polar and non-polar solvents, as well as Soxhlet extraction resulted in the formation of a reddish solid material (5.2% and 14.2% yield, respectively). Successive TLC and column chromatography of the solid material on silica gel with methanol as the mobile phase, gave three fractions with Rf = 0.21, 0.48 and 0.68. The fraction with 1 13 Rf = 0.68 was the major one. HNMR, CNMR, IR, UV and Mass spectra of this fraction were taken. On the basis of the results obtained from the spectra, the chemical structure of alizarin was determined and confirmed. Keywords: Alizarin, 1,2-dihydroxy-9,10-anthraquinone, 1,2-dihydroxy-9,10-anthracenedione, Rubia tinctorum, madder roots, ruberythric acid.
    [Show full text]
  • Natural Hydroxyanthraquinoid Pigments As Potent Food Grade Colorants: an Overview
    Review Nat. Prod. Bioprospect. 2012, 2, 174–193 DOI 10.1007/s13659-012-0086-0 Natural hydroxyanthraquinoid pigments as potent food grade colorants: an overview a,b, a,b a,b b,c b,c Yanis CARO, * Linda ANAMALE, Mireille FOUILLAUD, Philippe LAURENT, Thomas PETIT, and a,b Laurent DUFOSSE aDépartement Agroalimentaire, ESIROI, Université de La Réunion, Sainte-Clotilde, Ile de la Réunion, France b LCSNSA, Faculté des Sciences et des Technologies, Université de La Réunion, Sainte-Clotilde, Ile de la Réunion, France c Département Génie Biologique, IUT, Université de La Réunion, Saint-Pierre, Ile de la Réunion, France Received 24 October 2012; Accepted 12 November 2012 © The Author(s) 2012. This article is published with open access at Springerlink.com Abstract: Natural pigments and colorants are widely used in the world in many industries such as textile dying, food processing or cosmetic manufacturing. Among the natural products of interest are various compounds belonging to carotenoids, anthocyanins, chlorophylls, melanins, betalains… The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature, the first one ever published. Trends in consumption, production and regulation of natural food grade colorants are given, in the current global market. The second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds, their properties and their biosynthetic pathways. Main natural sources of such pigments are summarized, followed by discussion about toxicity and carcinogenicity observed in some cases. As a conclusion, current industrial applications of natural hydroxyanthraquinoids are described with two examples, carminic acid from an insect and Arpink red™ from a filamentous fungus.
    [Show full text]
  • Sorptive Elimination of Alizarin Red-S Dye from Water Using Citrullus Lanatus Peels in Environmentally Benign Way Along with Equilibrium Data Modeling
    Asian Journal of Chemistry; Vol. 25, No. 10 (2013), 5351-5356 http://dx.doi.org/10.14233/ajchem.2013.14179 Sorptive Elimination of Alizarin Red-S Dye from Water Using Citrullus lanatus Peels in Environmentally Benign Way Along with Equilibrium Data Modeling * RABIA REHMAN and TARIQ MAHMUD Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan *Corresponding author: Fax: +92 42 99230998; Tel: +92 42 99230463; Ext: 870; E-mail: [email protected] (Received: 7 June 2012; Accepted: 3 April 2013) AJC-13203 Textile industry effluents comprised of various toxic and non biodegradable chemicals, especially non-adsorbed dyeing materials, having synthetic origin. Alizarin Red-S dye is one such examples. In this work, sorptive removal of Alizarin Red-S from water was investigated using Citrullus lanatus peels, in batch mode on laboratory scale. It was observed that adsorption of dye on Citrullus lanatus peels increases with increasing contact time and temperature, but decreases with increasing pH. Isothermal modeling indicated that physio- sorption occurred more as compared to chemi-sorption during adsorption of Alizarin Red-S by Citrullus lanatus peels, with qm 79.60 mg g-1. Thermodynamic and kinetic investigations revealed that this process was favourable and endothermic in nature, following pseudo- second order kinetics. Key Words: Citrullus lanatus peels, Alizarin Red-S, Adsorption, Isothermal modeling, Kinetics. INTRODUCTION Textile industries use a variety of dyeing materials for developing different colour shades. A massive amount of these dyes is wasted during processing which goes into effluents and poses problems for mankind and environmental abiotic and biotic factors by creating water pollution.
    [Show full text]
  • Authenticating Turkey Red Textiles Through
    ICOM-CC 18th Triennial Conference Authenticating Turkey red textiles 2017 Copenhagen through material investigations by TEXTILES FTIR and UHPLC JULIE H. WERTZ* INTRODUCTION University of Glasgow Glasgow, United Kingdom [email protected] The susceptibility of historical textiles to light fading is one of the primary ANITA QUYE concerns in their care and display, complicating the accessibility of these University of Glasgow Glasgow, United Kingdom collections. Turkey red, a cotton textile made by the eponymous and [email protected] distinctive dyeing process, was produced in Western Europe from the DAVID FRANCE University of Glasgow mid-18th to the early 20th century and was lauded by consumers, dyers, Glasgow, United Kingdom [email protected] and chemists for its exceptional fastness to light and wash fading. Display PIK LEUNG TANG practices can be improved by understanding the robustness of historical Agilent Technologies, Edinburgh Edinburgh, United Kingdom Turkey red in modern, scientific terms. This requires a more reliable means [email protected] than visual assessment to identify Turkey red, which this research has done LESLEY RICHMOND University of Glasgow through non-invasive Fourier transform infrared (FTIR) spectroscopy and Glasgow, United Kingdom micro-analysis by ultra-high-performance liquid chromatography (UHPLC). [email protected] *Author for correspondence HISTORICAL BACKGROUND KEYWORDS: textiles, Turkey red, dyeing, FTIR, chromatography, madder, synthetic alizarin Turkey red dyeing is specific to cellulosic fibres, primarily cotton, and follows an unusual and lengthy process that was said to yield ‘the most ABSTRACT brilliant and fastest madder red’ on cotton (Ure 1844). Success depended Nineteenth-century Turkey red, a cotton textile on familiarity with the technique, which varied between dyers and firms dyed by a peculiar and unique process, is found but followed the same general principles (Wertz 2017).
    [Show full text]
  • Authenticating Turkey Red Textiles Through Material
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Enlighten: Publications ICOM-CC 18th Triennial Conference Authenticating Turkey red textiles 2017 Copenhagen through material investigations by TEXTILES FTIR and UHPLC JULIE H. WERTZ* INTRODUCTION University of Glasgow Glasgow, United Kingdom [email protected] The susceptibility of historical textiles to light fading is one of the primary ANITA QUYE concerns in their care and display, complicating the accessibility of these University of Glasgow Glasgow, United Kingdom collections. Turkey red, a cotton textile made by the eponymous and [email protected] distinctive dyeing process, was produced in Western Europe from the DAVID FRANCE University of Glasgow mid-18th to the early 20th century and was lauded by consumers, dyers, Glasgow, United Kingdom [email protected] and chemists for its exceptional fastness to light and wash fading. Display PIK LEUNG TANG practices can be improved by understanding the robustness of historical Agilent Technologies, Edinburgh Edinburgh, United Kingdom Turkey red in modern, scientific terms. This requires a more reliable means [email protected] than visual assessment to identify Turkey red, which this research has done LESLEY RICHMOND University of Glasgow through non-invasive Fourier transform infrared (FTIR) spectroscopy and Glasgow, United Kingdom micro-analysis by ultra-high-performance liquid chromatography (UHPLC). [email protected] *Author for correspondence HISTORICAL BACKGROUND KEYWORDS: textiles, Turkey red, dyeing, FTIR, chromatography, madder, synthetic alizarin Turkey red dyeing is specific to cellulosic fibres, primarily cotton, and follows an unusual and lengthy process that was said to yield ‘the most ABSTRACT brilliant and fastest madder red’ on cotton (Ure 1844).
    [Show full text]
  • Anthraquinones Mireille Fouillaud, Yanis Caro, Mekala Venkatachalam, Isabelle Grondin, Laurent Dufossé
    Anthraquinones Mireille Fouillaud, Yanis Caro, Mekala Venkatachalam, Isabelle Grondin, Laurent Dufossé To cite this version: Mireille Fouillaud, Yanis Caro, Mekala Venkatachalam, Isabelle Grondin, Laurent Dufossé. An- thraquinones. Leo M. L. Nollet; Janet Alejandra Gutiérrez-Uribe. Phenolic Compounds in Food Characterization and Analysis , CRC Press, pp.130-170, 2018, 978-1-4987-2296-4. hal-01657104 HAL Id: hal-01657104 https://hal.univ-reunion.fr/hal-01657104 Submitted on 6 Dec 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Anthraquinones Mireille Fouillaud, Yanis Caro, Mekala Venkatachalam, Isabelle Grondin, and Laurent Dufossé CONTENTS 9.1 Introduction 9.2 Anthraquinones’ Main Structures 9.2.1 Emodin- and Alizarin-Type Pigments 9.3 Anthraquinones Naturally Occurring in Foods 9.3.1 Anthraquinones in Edible Plants 9.3.1.1 Rheum sp. (Polygonaceae) 9.3.1.2 Aloe spp. (Liliaceae or Xanthorrhoeaceae) 9.3.1.3 Morinda sp. (Rubiaceae) 9.3.1.4 Cassia sp. (Fabaceae) 9.3.1.5 Other Edible Vegetables 9.3.2 Microbial Consortia Producing Anthraquinones,
    [Show full text]
  • Enhancement of Malignant Transformation of C3H Mouse Fibroblasts and Growth Stimulation of Primary Rat Hepatocytes1
    (CANCER RESEARCH 50. 6540-6544. October 15. 1990] Hydroxyanthraquinones as Tumor Promoters: Enhancement of Malignant Transformation of C3H Mouse Fibroblasts and Growth Stimulation of Primary Rat Hepatocytes1 Detlef NVölfle,2ChristophSchmutte, Johannes Westendorf, and Hans Marquardt Department of Toxicology, L'nirersity of Hamburg Medical School, D-2001) Hamburg 13, Federal Republic of Germany ABSTRACT discrepancy has been discussed (5). Since the mouse strain used in the in vivo experiments had a relatively high incidence of Because danthron, though carcinogenic, does not seem to be genotoxic, spontaneous hepatomas, the results do not support an initiating it and 8 other hydroxyanthraquinones were comparatively investigated activity of danthron in the liver. for activities associated with tumor promotion, such as stimulation of cell Nongenotoxic carcinogens often possess tumor-promoting proliferation and enhancement of malignant transformation. The in vivo treatment of primary rat hepatocytes with danthron, aloe-emodin, chry- activity (10-13). Fundamental characteristics of promoting sophanol, and rhein resulted in a 2-3-fold increase of D.NA synthesis, agents are the modulation of growth control (14-16) and dif lucidin and purpurin were less active, and emodin, purpuroxanthin, and ferentiation (16). In experimental hepatocarcinogenesis, tumor alizarin were essentially inactive. In addition, danthron, rhein, and chry- promotion can be achieved: (a) by cytotoxins that stimulate sophanol (preliminary data), but not alizarin, enhanced transformation of regenerate growth of toxin-resistant cells (17); or (b) by chronic C3H/M2 mouse fibroblasts initiated by /V-methyl-A''-nitro-A'-nitroso- administration of mitogens without toxic effects, i.e., inducers guanidine or 3-methylcholanthrene. The results of these in vitro studies of drug-metabolizing enzymes, peroxisome proliferators, or suggest that hydroxyanthraquinones, possessing 2 hydroxy groups in the hormones (14).
    [Show full text]
  • Assessment of Potential Toxicity of Alizarin Through Resonance Light Scattering
    Asian Journal of Chemistry; Vol. 25, No. 2 (2013), 1015-1020 http://dx.doi.org/10.14233/ajchem.2013.13365 Assessment of Potential Toxicity of Alizarin Through Resonance Light Scattering * CHA-CHA LI, JUN-SHENG LI , GUO-XIA HUANG, QI-QIAN LI and LIU-JUAN YAN Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou 545006, Guangxi Province, P.R. China *Corresponding author: Fax: +86 772 2687033; Tel: +86 772 2685200; E-mail: [email protected] (Received: 30 December 2011; Accepted: 30 August 2012) AJC-12033 Alizarin is a kind of natural pigment. In this paper, saturation value binding with DNA of alizarin can be calculated by the resonance scattering spectrum and then is compared with mitoxantrone, chrysophano and rhein. Alizarin's potential toxicity is far lower than mitoxantrone and is slightly lower than chrysophano and rhein. The saturation value binding with DNA of alizarin can be influenced by many factors through studying different factors that influence the saturation value, that means the potential toxicity of alizarin are influenced by many factors. The saturation value at alizarin-DNA-pH 7.46 is 0.20. The saturation value at alizarin-DNA-pH 7.46-valine, alizarin- DNA-pH 7.46-leucine, alizarin-DNA-pH 7.46-histidine, alizarin-DNA-pH 7.46-aspartate, alizarin-DNA-pH 7.46- tryptophan, alizarin- DNA-pH 7.46-sodium chloride, alizarin-DNA-pH 7.46-glucose, alizarin-DNA-pH 6.44 and alizarin-DNA-pH 8.21 are 0.20, 0.20, 0.19, 0.24, 0.30, 0.4, 0.17, 0.17 and 0.19 respectively.
    [Show full text]
  • Hydroxyanthraquinone Dyes From
    HYDROXYANTHRAQUINONE DYES FROM PLANTS Yanis Caro, Thomas Petit, Isabelle Grondin, Mireille Fouillaud, Laurent Dufossé To cite this version: Yanis Caro, Thomas Petit, Isabelle Grondin, Mireille Fouillaud, Laurent Dufossé. HYDROXYAN- THRAQUINONE DYES FROM PLANTS. Symposium on natural colorants “Plants, Ecology and Colours”, May 2017, Antananarivo, Madagascar. 2017. hal-01518543 HAL Id: hal-01518543 https://hal.archives-ouvertes.fr/hal-01518543 Submitted on 4 May 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. HYDROXYANTHRAQUINONE DYES FROM PLANTS Yanis CARO*,1, Thomas PETIT2, Isabelle GRONDIN1 , Mireille FOUILLAUD1 and Laurent DUFOSSE1 1 Laboratoire LCSNSA, Université de La Réunion (France); 2 UMR Qualisud, Université de La Réunion (France) Introduc)on In the plant kingdom, numerous pigments have already been iden)fied, but only a minority of them is allowed by legal regulaons for texMle dyeing, food coloring or cosmeMc and pharmaceuMcs’ purpurin physcion chrysophanol manufacturing. Anthraquinones, produced as secondary metabolites in plants, cons)tute a large structural hypericin variety of compounds among the quinone family. Anthraquinones are structurally built from an anthracene skyrin ring with a keto group on posi)on 9,10 as basic core and different func)onal groups such as -OH, -CH3, - rhein damnacanthal emodin ruberythric acid COOH, etc.
    [Show full text]