Neuroanatomy Crash Course
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Neuroanatomy Crash Course Jens Vikse ∙ Bendik Myhre ∙ Danielle Mellis Nilsson ∙ Karoline Hanevik Illustrated by: Peder Olai Skjeflo Holman Second edition October 2015 The autonomic nervous system ● Division of the autonomic nervous system …………....……………………………..………….…………... 2 ● Effects of parasympathetic and sympathetic stimulation…………………………...……...……………….. 2 ● Parasympathetic ganglia ……………………………………………………………...…………....………….. 4 Cranial nerves ● Cranial nerve reflexes ………………………………………………………………….…………..…………... 7 ● Olfactory nerve (CN I) ………………………………………………………………….…………..…………... 7 ● Optic nerve (CN II) ……………………………………………………………………..…………...………….. 7 ● Pupillary light reflex …………………………………………………………………….…………...………….. 7 ● Visual field defects ……………………………………………...................................…………..………….. 8 ● Eye dynamics …………………………………………………………………………...…………...………….. 8 ● Oculomotor nerve (CN III) ……………………………………………………………...…………..………….. 9 ● Trochlear nerve (CN IV) ………………………………………………………………..…………..………….. 9 ● Trigeminal nerve (CN V) ……………………………………………………................…………..………….. 9 ● Abducens nerve (CN VI) ………………………………………………………………..…………..………….. 9 ● Facial nerve (CN VII) …………………………………………………………………...…………..………….. 10 ● Vestibulocochlear nerve (CN VIII) …………………………………………………….…………...…………. 10 ● Glossopharyngeal nerve (CN IX) …………………………………………….……….…………...………….. 10 ● Vagus nerve (CN X) …………………………………………………………..………..…………...………….. 10 ● Accessory nerve (CN XI) ……………………………………………………...………..…………..………….. 11 ● Hypoglossal nerve (CN XII) …………………………………………………..………..…………...………….. 11 Tracts of the spinal cord ……………………………………………….....................…………..………….. 11 Other highyields ● Cranial nerve nuclei ……...……...……...……...……...……...……...……...………...…………..………….. 15 ● Innervation of larynx ……...……...……...……...……...……...……...……...…………………….………….. 16 ● Recurrent laryngeal nerve ……...……...……...……...……...……...……...………….………….………….. 16 ● Phrenic nerve ……...……...……...……...……...……...……...……...……...………..…………..………….. 16 ● Tongue innervation ……...……...……...……...……...……...……...……...……...….…………..………….. 16 ● Vagal (CN X) nuclei ……...……...……...……...……...……...……...……...……………………..………….. 16 ● Aqueous humor ……...……...……...……...……...……...……...……...……...………………….………….. 16 ● Paranasal sinuses and nasolacrimal duct ……...……...……...……...……...……….…………..…………. 17 ● Colliculi and geniculate bodies ……...……...……...……...……...……...……...…….…………..…………..17 ● Superior cervical ganglia ……...……...……...……...……...……...……...……..…….…………..…………. 17 ● Meninges and spaces ……...……...……...……...……...……...……...……...……….………….………….. 17 ● Structures associated with spinal cord ……...……...……...……...……...…………..…………..………….. 17 ● Cerebrospinal fluid ……...……...……...……...……...……...……...……...……...…..…………..………….. 17 ● Choroid plexus ……...……...……...……...……...……...……...……...……...……….…………..………….. 18 ● Cerebral circulation ……...……...……...……...……...……...……...……...………………………..………. 18 ● Common tendinous ring ……...……...……...……...……...……...……...……...…….………….…………...20 Highyield review questions ……………………………………………………………………………….. 21 1 THE AUTONOMIC NERVOUS SYSTEM (ANS) The ANS ONLY affects smooth muscle, cardiac muscle and glands (involuntary). EFFECTS OF PARASYMPATHETIC & SYMPATHETIC STIMULATION Parasympathetic (PSANS) Sympathetic (SANS) Eye Pupils constrict (miosis) Pupils dilate (mydriasis) Salivary gland Watery secretion Thick, viscous secretion Heart rate (HR) ⬇ HR ⬆ HR and contractile strength Lungs Bronchoconstriction Bronchodilation Liver/gallbladder Emission of bile Release of sugar Bladder Urination Urination blocked 2 PARASYMPATHETIC STIMULATION (Rest and Digest) SYMPATHETIC STIMULATION (Fight or Flight) 3 PARASYMPATHETIC GANGLIA 4 5 6 CRANIAL NERVE REFLEXES Afferent = sensory // Efferent = Effector (motor/parasympathetic) Afferent (sensory) limb Efferent (Effector) limb Pupillary light II (optic) III (oculomotor)1 Corneal (blink) V1 (ophthalmic division of trigeminal) VII (facial)2 Jaw jerk V3 (mandibular division of trigeminal) V3 (mandibular division of trigeminal) Gag IX (glossopharyngeal) X (vagus) Cough X (vagus) X (vagus) 1 Parasympathetic fibers from EdingerWestphal nucleus of CN III (travels to ciliary ganglion → sphincter mm) 2 Orbicularis oculi (innervated by facial nerve) closes the eye CRANIAL NERVES (CN) Nerve components: sensory (S) +/ motor (M) +/ parasympathetic (PSANS) CN I: Olfactory nerve ● Olfaction (smell): the only sense that is NOT relayed by thalamus ● Exits skull through cribriform plate of ethmoid bone CN II: Optic nerve ● Vision ● Afferent limb of pupillary light reflex ● Exits skull through optic canal (optic canal: optic nerve, ophthalmic artery) Pupillary light reflex pathway ● Ipsilateral optic nerve (CN II) afferent limb ● Ipsilateral pretectal nucleus ● BILATERAL EdingerWestphal nucleus (PSANS nucleus of CN III) ● Bilateral oculomotor nerves (CN III) efferent limb ● Bilateral ciliary ganglia ● Bilateral short ciliary nerves ● Result: BOTH (bilateral) eyes constricts (miosis) 7 Visual field defects Eye dynamics ● Extraocular muscle innervation: SO4LR6R3 ○ Superior Oblique = CN4, Lateral Rectus = CN6; Rest = CN3 ● Oblique muscles (sup/inf) moves eye in Opposite direction (superior moves eye DOWN) ● Parasympathetic (PSANS) fibers cause constriction of the pupil (sympathetic: dilation) 8 CN III: Oculomotor nerve (CNs with parasympathetic fibers: III, VII, IX, X) ● Eye movements: all except SO and LR (SO4LR6R3) ○ Superior rectus, inferior rectus, medial rectus, inferior oblique, levator palpebrae ● Efferent limb of pupillary light reflex ○ PSANS fibers from EW nucleus causes pupillary constriction ● Exits the skull through superior orbital fissure (SOF: III, IV, V1, VI, ophthalmic vein) ● Lesion to CN III: ○ Pupil looks down and out (unopposed lateral rectus (CN VI) and superior oblique (CN IV)) ○ Ptosis (loss of innervation of levator palpebrae) ○ “Blown pupil” (dilated pupil due to loss of PSANS fibers from EW nucleus of CN III) CN IV: Trochlear nerve ● Innervates superior oblique, which moves the eye DOWN (SO4LR6R3) ● The only nerve that exits from the dorsal aspect of the brainstem ● Exits the skull through superior orbital fissure (SOF: III, IV, V1, VI, ophthalmic vein) CN V: Trigeminal nerve (V1 = ophthalmic; V2 = maxillary; V3 = mandibular) ● Afferent limb of corneal (blink) reflex (V1) ● Afferent AND efferent limbs of jaw jerk reflex (V3) ● Innervates muscles of mastication (V3): ○ teMporalis, Masseter, Medial pterygoid Moves the mandible up ○ Lateral pterygoid Lowers the mandible ● SENSATION from anterior ⅔ of tongue (V3) (NB: taste = CN VII) ● SENSATION from face (V1, V2 and V3) (NB: muscles of facial expression = CN VII) Mnemonic (where the divisions of CN V exits the skull): Scandale Royal Orgy ● V1 (ophthalmic): Superior orbital fissure (SOF: III, IV, V1, VI, ophthalmic vein) ● V2 (maxillary): foramen Rotundum ● V3 (mandibular): foramen Ovale CN VI: Abducens nerve ● Innervates lateral rectus (SO4LR6R3) ● Exits the skull through superior orbital fissure (SOF: III, IV, V1, VI, ophthalmic vein) 9 CN VII: Facial nerve (CNs with parasympathetic fibers: III, VII, IX, X) ● Efferent limb of corneal (blink) reflex (orbicularis oculi mm) ● Muscles of facial expression ● TASTE from anterior ⅔ of tongue (chorda tympani) (NB: sensation = CN V3) ● Innervation of all glands EXCEPT parotid gland (parotid gland: CN IX) ○ Submandibular, sublingual, lacrimal gland, nasal gland, palatine gland ○ Note: facial nerve passes THROUGH parotid gland, but does not innervate it ■ In parotid gland, the facial nerve gives off its terminal branches ● Innervates stapedius muscle of inner ear ● Nerves in cerebellopontine angle: CN VII and CN VIII ● Path: internal acoustic meatus → facial canal → stylomastoid foramen ● UMN lesion: contralateral paralysis of lower face ● LMN lesion (Bell’s palsy): ipsilateral paralysis of upper & lower face Terminal branches of facial nerve (from superior to inferior): To Zanzibar By Motor Car ● Temporal, Zygomatic, Buccal, Marginal mandibular, Cervical Chorda tympani ● Path: facial canal (from CN VII) → between malleus & incus → petrotympanic fissure ● Contains: ○ Preganglionic parasympathetic fibers (synapse on submandibular ganglion) ○ Somatic visceral afferent fibers from anterior ⅔ of tongue (taste) CN VIII: Vestibulocochlear nerve ● Nerves in cerebellopontine angle: CN VII and CN VIII CN IX: Glossopharyngeal nerve (CNs with parasympathetic fibers: III, VII, IX, X) ● Afferent limb of gag reflex (efferent: CN X) ● Sensation AND taste from posterior ⅓ of tongue ● Innervation of parotid gland (NB: all other glands = CN VII) ● Exits skull through jugular foramen (jugular foramen = IX, X, XI) CN X: Vagus nerve (CNs with parasympathetic fibers: III, VII, IX, X) ● Efferent limb of gag reflex ● Afferent AND efferent limb of cough reflex ● Taste and sensation from epiglottis ● Talking, coughing, swallowing ● Parasympathetic innervation to organs in thorax and abdomen ● Sensation AND taste from epiglottis + sensation from carotid and aortic bodies ● Innervation of larynx (recurrent laryngeal nerve) ● Midline uvula (lesion → uvula deviates to contralateral side) ● Exits skull through jugular foramen (jugular foramen = IX, X, XI) 10 CN XI: Accessory nerve ● Innervates