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Xarxes De Control Biològic PARC RECERCA BIOMÈDICA BARCELONA CONNECTEM CIÈNCIA I DIVERSITAT EN UN ESPAI CREATIU ÚNIC Novembre de 2013 NÚM. 69 www.prbb.org GRATUÏT Editorial 12è SIMPOSI ANUAL DEL CRG / 12th CRG ANNUAL SYMPOSIUM Campus Mar: new facilities n recent months almost all the work on our teaching Ibuilding has been finished. The new facilities include a well-equipped modern clas- sroom, which should cover the wide-ranging needs of the many degrees that are taught here. At the moment, it hosts all the courses of the joint Bachelor of Medicine (UPF-UAB), the UPF Human Biology degree, Physio- therapy at the UAB and Nursing School, and the first three cour- ses of the Bachelor’s degree in Biomedical Engineering from the UPF. To the traditional classrooms and labs, we have added semi- nar rooms, as well as others for practicing clinical skills and simulations. It is also expected that in the future a dissection room will be added. Of course, a small organisa- tional effort will have to be made in order to accommodate and develop all these activities in the renovated building, which is big... but not infinite. Nutritional and social needs have not been forgotten, and a cafe is to open shortly. Xarxes de control biològic Joaquim Gea, UPF James Sharpe, organitzador de gy”, explains James Sharpe, or- Maruxa Martínez-Campos Biological Control Networks Campus Mar: l’acte. «Hi ha molts tipus dife- ganiser of the meeting. “There noves instal·lacions l 12è Simposi del CRG va rents de xarxes en biologia, però he 12th CRG Symposium are many different types of net- en última instància tots ells han took place on October work in biology, but ultimately n els últims mesos s’han tenir lloc el 30 i 31 d’octu- evolucionat per controlar alguna 30-31. About 250 scien- they have all evolved to control ultimat pràcticament bre. Prop de 250 científics T E tists from different institutions totes les obres del nos- procedents de diferents instituci- cosa, ja sigui el metabolisme, el something, whether it’s meta- E ons a Barcelona, però també del destí cel·lular o la conducta. Per in Barcelona, as well as the UK, bolism, cell fate or behaviour. I tre edifici docent. Les noves US, Belgium, Germany, the instal·lacions compten amb un Regne Unit, els EUA, Bèlgica, Ale- tant, he volgut agrupar aquestes therefore wanted to bring these Czech Republic, Greece and aulari modern i ben equipat, manya, República Txeca, Grècia i diferents perspectives en la de- different perspectives together Italy, amongst others, gathered amb el qual intentarem cobrir Itàlia, entre d’altres, es van reunir nominació “Xarxes Biològiques under the phrase Biological in the PRBB Auditorium. The les necessitats dels nombrosos a l’Auditori del PRBB. Els partici- de Control – BCN”, que també Control Networks – BCN, which researchers, from lab techni- graus que s’hi imparteixen. pants, des de tècnics de laborato- serveix per destacar que a Bar- also serves to emphasise that cians to group leaders, met to En aquest moment, estan ja ri fins a caps de grup, van parlar celona s’hi fa una gran recerca», great science is alive and well in actius tots els cursos del grau sobre xarxes biològiques. afegeix el científic. talk about biological networks. Barcelona!”, adds the scientist. compartit de Medicina (UPF- «El concepte de xarxa, d’una Els ponents internacionals van “The concept of network, The list of international UAB), del grau de Biologia Hu- sèrie de components que inte- tractar molts tipus diferents de of a series of components in- speakers covered many diffe- mana de la UPF, del de Fisioterà- ractuen entre si, és un bon marc xarxes, incloent-hi les d’interac- teracting with each other, is rent types of networks, inclu- pia de la UAB i del d’Infermeria per a la comprensió de moltes cions entre proteïnes, les xarxes a good flexible framework for ding protein-protein maps, dy- de l’Escola Universitària d’Infer- qüestions biològiques, des de de dinàmiques cel·lulars, xarxes understanding a wide range of namic cellular networks, regu- meria, així com els tres primers la regulació de gens i la biologia reguladores de la formació de biological questions, from gene latory networks for patterning cursos del grau d’Enginyeria cel·lular fins a la neurociència i teixits, el disseny de xarxes bio- regulation and cell biology to tissues, the design of synthetic Biomèdica de la UPF. l’evolució, i és fonamental per a lògiques sintètiques o l’evolució neuroscience and evolution, biology networks and network A les tradicionals aules i la biologia de sistemes», explica de xarxes. and is central to systems biolo- evolution ■ als laboratoris, s’hi han afegit ara sales per a seminaris i au- les d’habilitats i simulació de situacions clíniques. També DESTACAT / HIGHLIGHT està previst que en el futur es disposi de sala de dissecció. Arquitectura i ciència Aprofitant el festival, el pro- Architecture and science every kind, shape and size, for a Naturalment, haurem de grama de televisió El problema weekend. Taking advantage of the fer un petit esforç organitzatiu Unes 300 persones van visitar de Gettier ha fet un reportatge Around 300 people visited the festival, the television show “The per poder encabir i desenvolu- el PRBB entre el dissabte 19 i el sobre arquitectura científica PRBB between Saturday 19 and Gettier problem”, made a pro- par totes aquestes activitats a diumenge 20 d’octubre durant centrat en el PRBB, amb una Sunday 20 of October during the gramme on scientific architecture l’edifici renovat, que és gran... el festival d’arquitectura 48h entrevista a l’arquitecte Manel 48h Open House Barcelona festi- focusing on the PRBB, including però no infinit. No s’han obli- Open House Barcelona, que Brullet i un passeig per l’edifici. val of architecture. an interview with the architect dat tampoc les necessitats so- des del 2010 obre les portes, de Es podrà veure als canals de This festival, which takes place Manel Brullet and a stroll through cials i nutritives, i en breu dis- forma gratuïta, de més de 150 televisió local de Catalunya el in several cities worldwide, has the building. You can watch it on posarem d’una cafeteria. edificis de Barcelona de tot ti- 13 de novembre o al web www. since 2010 been opening the November 13 on local Catalan Joaquim Gea, UPF pus, forma i mida durant un laxarxa.com/elproblemadeget- doors, free of charge, of more than channels, or on the web www.lax- cap de setmana. tier. 150 of Barcelona’s buildings, of arxa.com/elpro blemadegettier ■ Ciència www.prbb.org | novembre de 2013 2 PERFIL DE GRUP / GROUP PROFILE FRANCESC POSAS I EULÀLIA DE NADAL - GRUP DE RECERCA EN SENYALITZACIÓ CEL·LULAR (CEXS-UPF) «Estudiem l’adaptació als canvis» Maruxa Martínez-Campos After this emergency stop, the cell ac- tivates the transcription of genes able to daptar-se o morir. Aquest principi cope with the new conditions. “We don’t darwinià és aplicable no només als just look at which genes are activated by Aorganismes, sinó també a cadascu- MAPKs —there can be up to 500 in res- na de les cèl·lules que els formen. Totes elles ponse to stress— but also how their ex- han de ser capaces d’adaptar-se als canvis pression is regulated: the modification of que es produeixen en el seu entorn i respon- chromatin, the initiation of transcription, dre adequadament per poder sobreviure. El the export and translation of messenger grup de recerca en Senyalització Cel·lular R N A ”. del CEXS-UPF estudia precisament com les cèl·lules detecten aquests canvis i hi respo- Biological computing nen. El grup va néixer a finals del 1999 amb Els investigadors Francesc Posas i Eulàlia de Nadal amb el seu equip Researchers Francesc Posas and Eulàlia de Nadal with their team Five years ago the lab began a new project, Eulàlia de Nadal i Francesc Posas, que actu- making inroads into the field of synthetic alment és vicerector de Política Científica de ordinadors: reben informació i responen “We study adaptation to change” biology. “Cells are like computers: they la UPF. Tots dos colideren el laboratori inte- en conseqüència. Per tant, la pregunta òb- receive information and respond accor- grat per unes 24 persones, on duen a terme dapt or die. This Darwinian prin- via és: podem controlar aquesta resposta?». dingly. So the obvious question is: can we estudis amb el llevat Saccharomyces cerevi- ciple is applicable not only to or- Això és el que intenten fer, en estreta col- control this response?”. This is what they siae i amb cèl·lules de mamífer. ganisms, but each of the cells that laboració amb el grup de Ricard Solé (UPF) A try to do, in close collaboration with Ricard El primer pas en la resposta adaptativa és make them up. They must all be able to i el finançament del Consell Europeu de Re- Solé’s group (UPF) and with European Re- transmetre a l’interior de la cèl·lula que s’ha adapt to changes in their environment cerca (ERC). Aquesta línia de recerca és més search Council (ERC) funding. This line of produït un canvi, i hi ha unes vies de senya- and respond appropriately in order to propera del que sembla a l’interès principal research is closer than it may appear to the lització encarregades d’aquesta transferèn- survive. The Cell Signalling research del laboratori. «Per manipular el comporta- main interest of the laboratory. “In order cia d’informació. El grup s’ha centrat en les group at the CEXS-UPF studies precisely ment de les cèl·lules, és essencial entendre to manipulate cell behaviour it is essential vies de les MAPK activades per estrès, les how cells detect and respond to these com aquestes transfereixen la informació, i to understand how cells transfer informa- SAPK.
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