N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton
BRIEF COMMUNICATION www.jasn.org N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton †‡ † | † Markus M. Rinschen,* § Ann-Kathrin Hoppe,* Florian Grahammer, ¶ Martin Kann,* † † † †‡ Linus A. Völker,* Eva-Maria Schurek,* Julie Binz,* Martin Höhne,* § Fatih Demir,** | †† † ‡‡ Milena Malisic,** Tobias B. Huber, ¶ Christine Kurschat,* Jayachandran N. Kizhakkedathu, †‡ †‡ Bernhard Schermer,* § Pitter F. Huesgen,** and Thomas Benzing* § *Department II of Internal Medicine, †Center for Molecular Medicine Cologne (CMMC), ‡Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and §Systems Biology of Ageing Cologne (Sybacol), BRIEF COMMUNICATION University of Cologne, Cologne, Germany; |Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ¶Department of Medicine IV, Medical Center and Faculty of Medicine – University of Freiburg, Freiburg, Germany; **Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany; ††BIOSS Centre for Biological Signalling Studies and Center for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University, Freiburg, Germany; and ‡‡Centre for Blood Research, Department of Pathology and Laboratory Medicine, Department of Chemistry, University of British Columbia, Vancouver, Canada ABSTRACT Regulated intracellular proteostasis, controlled in part by proteolysis, is essential in of these genes leads to altered signaling maintaining the integrity of podocytes
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