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Table of Content TABLE OF CONTENT Page 002 WELCOME NOTE Page 005 ORAL PROGRAMME Page 013 INVITED PLENARY SPEAKER BIOGRAPHIES & ABSTRACTS Page 038 ORAL ABSTRACTS Page 088 POSTER LIST Page 093 POSTER ABSTRACTS Page 158 LIST OF CONFERENCE PARTICIPANTS Page 166 CONFERENCE SPONSORS Page 168 CONFERENCE RELATED FUNCTIONS Page 1 of 170 WELCOME NOTE Page 2 of 170 Dear Delegate As the Director of the University of Pretoria Institute for Sustainable Malaria Control (UP ISMC), one of the South African Medical Research Council (MRC) Collaborating Centres for Malaria Research, I would like to personally welcome each of you to the 2nd South African Malaria Research Conference, 2016. The conference follows on the successful, first conference hosted by the MRC in Durban in 2015. This second national gathering of the malaria community will again provide researchers the opportunity to showcase novel findings, innovation, ground breaking research and ongoing collaborative efforts towards malaria elimination. With malaria elimination a foreseeable possibility in South Africa an urgent need exists for fundamental- and applied research and surveillance in malaria endemic areas to eliminate the disease through the use of an integrated management approach, including safer and sustainable alternative malaria control methods. A major hindrance in realising the goal of elimination in South Africa is the cross-border impact of malaria from our neighbouring countries. We are therefore very excited to welcome delegates from our neighbouring and other SADC countries as well as international guests doing research in these countries. The conference will be co-hosted by the UP ISMC and the MRC Office of Malaria Research (MOMR). Over the three day-long conference scheduled from 31 July to 2 August 2016 you can look forward to 61 oral presentations, of which 12 are plenary presentations, and 67 posters focusing on all facets of malaria. This includes human interventions towards malaria control and elimination including malaria education; health promotion and surveillance; novel methods to control the parasite and block transmission; innovative and alternative vector control methods; the use of various technologies to predict potential outbreaks and also the impact of climate change (remote sensing) and even the use of mathematical modelling to determine the effectiveness of new control tools. The conference will take place at the Auditorium at the University of Pretoria Groenkloof Campus in Pretoria, South Africa. The Groenkloof Campus is the home of the University of Pretoria’s Faculty of Education. The number of registered delegates expected to attend the conference is around 230, providing students the opportunity to share their malaria-related research and at the same time learn from experts in their respective fields. The conference will aim to save on paper usage and therefore the conference booklet will be available as an interactive document on the conference website for downloading. Delegates will receive a complimentary memory stick (flash drive) that will also contain the booklet and delegates will have the opportunity to add additional material including photos to their memory stick. Some background information on the UP ISMC. The Institute is a fully integrated, multi-disciplinary, interdepartmental and interfaculty initiative. The aim of the Institute is to coordinate and promote collaborative research on safer and sustainable malaria control and management strategies, and to generate new knowledge and support new activities pertaining to safe malaria control in Africa through fundamental and applied research, supported by research collaboration with regional, national and international partners. The diverse group of researchers within the Institute encompasses all aspects of malaria with research clusters focusing on human health, parasite control and vector control. The establishment of the UP ISMC was approved by the University of Pretoria Senate on 2 June 2016. The Institute was 'upgraded' from the existing UP Centre for Sustainable Malaria Control (UP CSMC), and boasts five years of achievements reached. The UP ISMC is also the proud host of the SARChI Chair on Sustainable Malaria Control. Page 3 of 170 I wish to thank all our sponsors in advance for contributing towards the conference. Without your contribution this conference would not have been possible. To the delegates participating either through an oral presentation or poster, thank you for sharing your research with all attending the conference. To all the attending delegates a word of thanks for your interest and valuable contribution. I believe that the conference will be informative and create a platform for networking. The conference tea/coffee breaks, lunches and, Cocktail and Gala functions will allow ample time to mingle and share ideas. I trust you will enjoy the conference and the hospitality that the University of Pretoria has to offer. Sincerely Tiaan de Jager Director: UP Institute for Sustainable Malaria Control Page 4 of 170 ORAL PROGRAMME Page 5 of 170 PROGRAMME DAY 1 | Sunday 31 July 2016 Time Event / Presentation title Speaker 09:30 - 11:30 Registration (Tea / Coffee) (posters to be put up) Tiaan de Jager 11:30 - 11:40 Welcome and opening address UP ISMC Lucille Blumberg 11:40 - 12:05 Setting the research agenda around malaria elimination NICD Towards malaria elimination in the MOSASWA (Mozambique, Patrick Moonasar 12:05 - 12:30 South Africa and Swaziland) region NDoH 12:30 - 13:30 Lunch (posters to be put up) Human and environmental aspects: Cross-border, regional control, health Session 1 promotion, malaria education and surveillance 13:30 - 17:00 Session Chairs: Tiaan de Jager (UP ISMC) & Patrick Moonasar (NDoH) Sunday Ukpe 13:30 - 13:50 Malaria Case Management in the context of Malaria Elimination: The role of the population at risk DoH Mpumalanga Leo Braack 13:50 - 14:10 Residual Malaria: Changed mind-sets to quell the seeds of failure UP ISMC Could a song about malaria prevention help protect children under Chad Anderson 14:10 - 15:00 five in Venda rural communities? UP ISMC 4 orals June Petersen Focus on malaria in education in South Africa UP ISMC 10 minutes talk, Eunice Misiani 2 minutes Q&A Malaria deaths: Meeting the 2015 near zero target in South Africa and/or NDoH discussion Targeting foci of transmission towards elimination of malaria in Natashia Morris South Africa MOMR / UP ISMC 15:00 - 15:30 Tea / Coffee (posters to be put up) Page 6 of 170 The impact of malaria program interventions and climate change Lactatia Motsuku on mortality and morbidity rates between 2009 and 2016 in Limpopo Province: Preliminary findings NDoH / UP ISMC Travel patterns and demographic characteristics of malaria cases, Deepa Pindolia the case study of Swaziland's active surveillance system, 2010- 2014 CHAI 15:30 - 17:00 Operational factors associated with increased detection of Khayelihle Bhangu 7 orals infections for reactive case detection (RACD) in Swaziland NMCP Swaziland 10 minutes talk, A study to identify high malaria risk groups and the associated risk Erastus Haindongo factors using a programmatic tool: Malaria elimination risk factor 2 minutes Q&A Uni Namibia and/or assessment discussion Imported cases, sporadic outbreaks and resurgence are the Kaka Mudambo highest threats to malaria elimination in the E8 region SARN - RBM The contribution of a sustainable volunteer base on cross-border Constance Njovu malaria elimination: An impact assessment FCBMI Facilitating factors and barriers to malaria research utilization for Chikondi Mwendera policy development in Malawi UP ISMC Cocktail welcoming 17:00 for 17:30 At conference venue Welcoming page 17:30 - 20:00 VIP guest speakers, entertainment, cocktail dinner and networking for programme Page 7 of 170 DAY 2 | Monday 1 August 2016 Time Event / Presentation title Speaker 07:30 - 08:30 Registration (Tea / Coffee) Session 2 Biology and epidemiology of the malaria parasite and transmission blocking 08:30 - 12:15 Session Chairs: Karen Barnes (UCT) & Erick Strauss (SU) Lyn-Marie Birkholtz 08:30 - 08:50 Seeing the wood for the trees: Malaria parasite systems biology and how it aids antimalarial drug discovery UP ISMC Mutant Malaria Parasites: An Overview on their Genetics, Origins Jaishree Raman 08:50 - 09:10 and Spread NICD Andrew Leisewitz Comparing canine Babesia rossi with human falciparum malaria UP ISMC 09:10 - 10:15 Starving malaria: Targeting nutrient uptake in the sexual, Jandeli Niemand 5 orals transmissible stages of Plasmodium falciparum parasites UP ISMC Plasmodium falciparum gametocytes show stage-specific, Riëtte van Biljon 10 minutes talk, chemotype specific transcriptional response to drug perturbation UP ISMC 2 minutes Q&A Synthesis and biological evaluation of heteroaromatic inhibitors of Amanda Rousseau and/or Plasmodium falciparum WITS discussion A comparative, transcriptomic analysis of the effects of a lead Jessica Connacher clinical candidate on the asexual and gametocyte stages of Plasmodium falciparum parasites UP ISMC Tea / Coffee 10:15 - 10:45 Poster session (Odd numbered posters) Quantitative profiling of the Plasmodium falciparum parasite’s Nanika Coetzee histone posttranslational modification landscape during sexual UP ISMC differentiation Cross-reactivity of oxidant drugs against asexual and gametocyte Dina Coertzen stages in Plasmodium falciparum parasites UP ISMC Heterogeneity of Plasmodium falciparum malaria in Matabeleland Gladwin Muchena 10:45 - 12:15 south: Analysis travel history reported by malaria
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