DOCSLIB.ORG

Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention University of Nebraska Medical Center DigitalCommons@UNMC Theses & Dissertations Graduate Studies Spring 5-4-2019 Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention Nathan Smith University of Nebraska Medical Center Follow this and additional works at: https://digitalcommons.unmc.edu/etd Part of the Nanomedicine Commons Recommended Citation Smith, Nathan, "Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention" (2019). Theses & Dissertations. 354. https://digitalcommons.unmc.edu/etd/354 This Dissertation is brought to you for free and open access by the Graduate Studies at DigitalCommons@UNMC. It has been accepted for inclusion in Theses & Dissertations by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention by Nathan Smith A Dissertation Presented to the Faculty of the University of Nebraska Medical Center Graduate College in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Medical Sciences Interdepartmental Area Specialization: Pharmacology and Experimental Neuroscience Under the Supervision of Dr. Howard E. Gendelman University of Nebraska Medical Center Omaha, Nebraska April, 2019 Supervisory Committee: Dr. Howard E. Gendelman, M.D. Dr. Larisa Poluektova, M.D., Ph.D. Dr. JoEllyn McMillan, Ph.D Dr. David Oupicky, Ph.D. Dr. Laura Bilek, PT, Ph.D. Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention Nathan Smith University of Nebraska Medical Center, 2019 Supervisor: Howard E. Gendelman, M.D. Abstract Over 30 years of antiretroviral therapy (ART) has transformed human immunodeficiency virus type one (HIV-1) outcomes from certain death to a nearly complete and normal life [1]. Though disease growth has slowed, the virus still creates substantial co-morbid diseases as well as social and economic burdens worldwide [2]. Lack of success with curative efforts combined with shortcomings in global treatment remain to be properly addressed. The requirement for daily use of combination antiretroviral drugs (ARVs) in low to middle income countries - where the majority of the HIV-1 positive population resides - can lead to breaks in regimen adherence due to a lack of access to ARV, high cost, social stigma, and lack of disease awareness [3]. Treatment breaks speed viral drug resistance and longer-term adverse events, ultimately shortening patient life-span. Hospital feedback in low to middle income countries indicates patient preference for a variety of treatment options, including long-acting (LA) strategies [4]. The need for treatment and by extension curative options is paramount in HIV-1 research. With an eye toward the future of HIV treatment, our laboratories generated a platform for small molecule antiretroviral drug nanoformulations by creating potent hydrophobic lipophilic ARV prodrugs with stable long-term physicochemical properties [5, 6]. Herein, this platform is extended to multiple small molecule inhibitors intended for antiviral therapy and HIV-1 eradication. A small molecule inhibitor used in cancer treatment was chemically modified to prolong drug activity, then tested for anti-HIV activities in the context of immune therapy in curative efforts. Additionally, two nucleoside reverse transcriptase inhibitors (NRTI) were chemically modified to produce long-acting drug iterations. Prodrug nuceloTide (ProTide) technology was used to chemically alter the NRTIs. A tenofovir ProTide was constructed and formulated, increasing prodrug accumulation. Following the same strategy, a phosphoroamidate prodrug nucleotide (ProTide) of lamivudine (3TC), called (M23TC) was synthesized and nanoformulated (NM23TC). A single treatment of NM23TC in human monocyte-derived macrophages (MDM) with NM23TC showed increased drug uptake, retention, intracellular 3TC triphosphate (3TC-TP) and sustained antiretroviral activities for 30 days. Pharmacokinetic analysis of NM23TC administered to Sprague Dawley rats showed sustained prodrug levels in blood and tissues. Further, in vitro studies showed intact prodrug was released over a month from MDMs. When tested in CEM CD4+ T cells, the prodrug was shown to rapidly convert to its 3TC-TP. Taken together, a putative mechanism for extended delivery of active compound to viral cell targets was constructed. This mechanism was strongly supported when tested as a broad- spectrum agent in model for hepatitis B virus infection in humanized mice. A single intramuscular injection produced sustained antiviral activities for one month. Taken together, the approaches give validation to potential value of the platform of transforming daily medications into nanoformulated prodrugs for long-acting antiviral activities. Table of Contents List of Figures and Tables .................................................................................. i List of Abbreviations .......................................................................................... ii Acknowledgements ............................................................................................ v Chapter 1: Background and Significance........................................................ 1 1.1. Global Impact and Challenges of the Human Immunodeficiency Virus..................... 2 1.2. HIV-1 Structure and Life Cycle ................................................................................ 2 1.3. Disease Timeline ..................................................................................................... 4 1.4. Host Immune Response .......................................................................................... 5 1.5. Reservoir Characterization ...................................................................................... 7 1.6. HIV-1 Eradication .................................................................................................... 8 1.7. HIV treatment ........................................................................................................ 10 1.8. Long Acting Nanomedicine for Antiretroviral Therapy ............................................ 15 1.8.1. Liposomes ..........................................................................................................17 1.8.2. Micelles ..............................................................................................................17 1.8.3. Polymer-Chemo Conjugates ...............................................................................18 1.8.4. Solid Lipid Nanoparticles (SLN) ..........................................................................18 1.8.5. Niosomes ...........................................................................................................19 1.8.6. Nanosuspensions ...............................................................................................19 1.8.7. Nanoparticle Systems and Characterization .......................................................19 1.9. Nanoparticle Preparation ....................................................................................... 21 1.10. Studying Antiviral Activity in Murine Mouse Models ............................................. 22 1.11. Scope and Significance of the Works Presented ................................................. 23 Chapter 2: Project Hypotheses and Goals .................................................... 34 2.1. Hypotheses and Aims ............................................................................................ 35 Project 1: IDO Inhibitor (Chapter 3) ...............................................................................35 Projects 2 and 3: Long-Acting NRTI ProTides (Chapters 4 and 5) ................................36 Quaternary aim (Chapter 6): NM23TC Testing Against Hepatitis B in Humanized Mice38 Chapter 3: Development and testing of a nanoformulated IDO inhibitor for HIV Eradication. ................................................................................................ 39 3.1. Abstract. ............................................................................................................... 40 3.2. Introduction.......................................................................................................... 40 3.3. Materials and Methods ........................................................................................ 44 3.3.1. Chemicals and Reagents ....................................................................................44 3.3.2. Synthesis and Characterization of Epacadostat Prodrugs...................................44 3.3.2.1. Synthesis of M1-Epacadostat ..........................................................................44 3.3.2.2. Synthesis of M2-Epacadostat ..........................................................................45 3.3.2.3. Synthesis of M3-Epacadostat ..........................................................................45 3.3.2.4. Synthesis of M4-Epacadostat ..........................................................................46 3.3.2.5. Prodrug Physicochemical Characterization ......................................................46 3.3.3. Folic Acid-P407 Conjugation ...............................................................................47 3.3.4. Epacadostat and M1-Epacadostat Formulation .................................................. 48 3.3.4.1. High-pressure
Load more

Recommended publications
  • LL 003 SOULS of MISCHIEF There Is Only Now LP
    ADRIAN YOUNGE PRESENTS... SOULS OF MISCHIEF THERE IS ONLY NOW SIDE ONE: (feat. Ali Shaheed Muhammed) 2. Time Stopped 3. Womack’s Lament (feat. Busta Rhymes) 4. Panic Struck (feat. Ali Shaheed Muhammed) 6. Another Part Of You (feat. William Hart) 7. All You Got Is Your Word 8. There Is Only Now (feat. Snoop Dogg) 9. Meeting Of The Minds SIDE TWO: (feat. Ali Shaheed Muhammed) 2. Miriam Got A Mickey 3. Stone Cold (feat. Scarub) 4. The Synopsis (feat. Ali Shaheed Muhammed) 5. Ghetto Superhero (feat. Ali Shaheed Muhammed) 7. Narrow Escape 8. Finally Back 9. The Last Act (feat. Ali Shaheed Muhammed) The sixth album from legendary hip-hop group Souls of Mischief, There Is Only Now, is a unique cinematic 90s crime tale of love, loss, and revenge. A conceptual collaboration with producer Adrian Younge and the first release on his freshly launched Linear Labs Records label, There Is Only Now gets its inspiration from a near fatal incident involving group members A-Plus, Opio, Tajai, and Phesto early in their careers. Set in 1994, There Is Only Now serves as a bookend to two decades of music since the release of their seminal debut album, ‘93 Til Infinity. There Is Only Now sees the Souls of Mischief crew members trading bars with a cast of hip-hop and soul luminaries. Narrated by A Tribe Called Quest member Ali Shaheed Muhammed—as DJ for fictional local Oakland radio station K-NOW—the album’s story unfolds under his all-seeing eye. Busta Rhymes makes an appearance as the story’s villain, Womack, on “Womack’s Lament,” while William Hart of the legendary vocal soul group, The Delfonics, lends his buttery falsetto to the contemplative “Another Side of You.” Snoop Dogg drops knowledge on the situation between Stoney and Womack with an ice cold verse on the title track “There Is Only Now,” and Scarub from Living Legends goes in on “Stone Cold.” Souls of Mischief and Adrian Younge have created a hip-hop album like no other.
    [Show full text]
  • Advocacy Day a Success What Is Advocacy? SHAY DENEY J
    Building a world class foster care system while serving our neighborhood youth March 2004 Foster Care and Homeless Youth Speak out Across the Nation Volume IV, Issue 3 Visit us online at www.mockingbirdsociety.org Advocacy Day a Success What is Advocacy? SHAY DENEY J. EBOH Advocate n- One who argues for a cause; a supporter ON FEBRUARY 9TH I dragged myself out of bed at 7:30 or defender. in the morning. For me that is the equivalent of waking -American Heritage Dictionary up at the crack of dawn. In a half-dead state, I walked down to the nearest bus stop and got on a bus headed in The right to advocate is a privilege given to every- the direction of the University District Youth Center in one who lives in America. If that is so, then why do Seattle. I wasn’t the only kid doing this. Over 100 youth most people not even know what it means? across the Puget Sound area in Washington State, on Most people think of advocacy as a difficult and their own free time, were loading themselves into vans overwhelming thing to get involved with. True, with their peers from group homes, shelters and local there are people who do it for a living: meeting with youth centers. We were all heading down to Olympia legislators all the time and constantly fighting for (Washington state capitol) to participate in Youth important issues. What most people don’t know, Advocacy Day. Senator Rosa Franklin, Mockingbird Times reporter Princess Hollins, Tonya Greenfield, service providers and youth.
    [Show full text]
  • MMS 001 MADLIB MEDICINE SHOW 1 Before the Verdict CD
    MADLIB LAUNCHES HIS ONCE-A-MONTH ALBUM SERIES Madlib launches the Madlib Medicine MP3 leak “The Paper” downloaded Show, a once-a-month, twelve-CD, 43,000 times on stonesthrow.com six-LP series with Before The Verdict. The as of 12/10… and counting Madlib Medicine Show will be a Marketed and promoted by combination of Madlib's new Hip Hop Stones Throw Records productions, remixes, beat tapes, and Publicity by Score Press Jazz, as well as mixtapes of Funk, Soul, Brazilian, Psych and other undefined Limited edition forms of music from the Beat Konducta's 4-ton* stack of vinyl. Format: CD Cat. No: MMS 001 Madlib Medicine Show No. 1 is Before Label: Madlib Medicine Show The Verdict featuring Guilty Simpson, a Available: February 2nd, 2010 seventeen track reimagination of rapper Guilty Simpson’s Ode To The Ghetto (augmented, of course, with unreleased songs, other remixes and tons o’ beats). You can think of this as somewhat of a prelude to Madlib & Guilty Simpson's forthcoming OJ Simpson album. Volume 1 is a limited pressing of CDs. Next up: Flight to Brazil, is a mixtape of Brazilian jazz, funk, prog-rock, folk and psychedelia coming in late February. Later releases will include Beat Konducta in Africa. *4-tons of vinyl, this is true. It’s all in his studio. The World-Psych Masterpiece from The Whitefield Brothers 1. Joyful Exaltation feat. Bajka 2. Safari Strut 3. Reverse feat. Percee P and MED 4. Taisho 5. Sad Nile 6. The Gift feat. Edan and Mr. Lif 7. Ntu 8.
    [Show full text]
  • Souls of Mischief Trilogy: Conflict, Climax, Resolution Mp3, Flac, Wma
    Souls Of Mischief Trilogy: Conflict, Climax, Resolution mp3, flac, wma DOWNLOAD LINKS (Clickable) Genre: Hip hop Album: Trilogy: Conflict, Climax, Resolution Country: US Released: 2000 MP3 version RAR size: 1139 mb FLAC version RAR size: 1502 mb WMA version RAR size: 1121 mb Rating: 4.1 Votes: 178 Other Formats: XM AIFF MPC MP4 DMF ADX AAC Tracklist Hide Credits 1 Intro 0:23 Trilogy 2 3:29 Producer – Tommy Tee The Interrogation 3 4:48 Producer – Domino Rap [Featuring] – Casual, Pep Love Last Night 4 3:49 Producer – Jay-Biz 5 Save The Babies (Conflict) 1:52 Bad Business 6 3:47 Keyboards – Amp Fiddler Danglin' 7 3:07 Producer – Tommy Tee Mama Knows Best 8 5:15 Bass, Guitar – Michael HamptonVocals [Additional] – George Clinton, Mystic 9 Medication 4:21 10 That Ain't Life (Conflict) 4:21 11 4th Floor Freaks 3:07 12 Acupunctere 4:14 13 Fucked... 4:00 Soundscience 14 Edited By – Matt Kelly*Engineer – Kut Masta KurtProducer, Mixed By – Babu, Evidence 4:36 Scratches – Babu 15 Supdoder (What's The Re?) 4:01 Airborne Rangers 16 4:19 Producer – Phesto Phoenix Rising (Resolution) 17 2:17 Rap [Featuring] – Mystic 18 Enemy Minds 4:28 Credits Mastered By – Ken Lee Mixed By – Matt Kelley (tracks: 1 to 13, 15 to 18) Producer – A-Plus (tracks: 5, 6, 15), Opio (tracks: 8, 9, 17, 18) Barcode and Other Identifiers Barcode: 655323010429 Other versions Category Artist Title (Format) Label Category Country Year Souls Of Trilogy: Conflict, Climax, 230104-4 Hiero Imperium 230104-4 US 2000 Mischief Resolution (Cass, Album) Souls Of Trilogy: Conflict, Climax, 230104-1
    [Show full text]
  • Souls of Mischief Anything Can Happen
    Anything Can Happen Souls of Mischief Yo, It's like this and only this, So I'm go'n tell Me and my moms in front of the mall, and then I seen this nigga, ramel From fifth grade, I knew this kid was swift Paid was how his mind logged, so he got his grind on But now it's years later, I say "hey" ta him He flash his fronts fulla au, and "hey you!" The warning drove from a seville as it sped by, Lead fly, ratta-tat-tatta, his blood spatta I strive ta, see the driva with my eye, Moms grabbed sky, and caught lead in her thigh, i Put her behind the trash can, dashed to my man, It was to late, it's sad that ramel was perferated Waited and sweated, for the medics as my moms bled Even if he was alive at the scene, by now my man ram's dead The cops do not care, 'cause our skin has too much shade in it' They'll dismiss this as some niggas misbehavin' But I'll never forget the driver of that blue seville And live for the day to bust shots in his grill, But still, I can't do this alone, My crew's line, so I slip two dimes into the pay phone. I'll stay home, get some rest, call my girl an' Tajai's on the phone, talkin' about the world's end What happened? Ya moms got capped an' ya nigga's dead? Ya talkin' about paybacks, and bullets in the head? Well 'um, hoodz come in dozens, but I got a cousin, That live around the block, an' they got a glock, An' we can swiftly bust 'em I trust 'em, Wit my life, an' plus the glock is light, an' Easily concealed, easy it'll peel a cap right Hey tajai, don't stop, rap too tight (opio: yo taj, man, you a'ight, man?
    [Show full text]
  • Spelman OTLIGHT the VOICE of AFRICAN AMERICAN WOMANHOOD
    I a Spelman OTLIGHT THE VOICE OF AFRICAN AMERICAN WOMANHOOD Vol. XXXK-NO. 4 November 17, 1993 If ;■ ; |S|!|| Inside: Lest iar 111-? r- ■ Bise» ■■ fl Jressei I lomo bia ISSI: id bi seepages6 & 7 see page 1 Spelmanites Offered Opportunities in Communications by Maleka N. Ingram Advertising Worldwide. Saatchi & goal of the Workshop is "to seek out Department of an agency, and Print Spelman College Career Planning Saatchi is one of the top three some of the most creatively talented Traffic operator. He later worked as a and Placement Center expands their advertising companies in the world. students at America’s finest colleges copywriter, and President and head of focuss on Careers in Communication. Gossett spoke to students in class and universities to introduce them to the Creative Department. Barbara Brown and Cheryl and at an information session about the creative work of advertising, and to When asked about the present being McGinnis, Director and Assistant opportunities and the future outlook of encourage them to consider the the opportune time for minorities in Director of the center, are concentrating advertising. advertising industry as an option." advertising Gossett commented, "It is more on opportunities for careers in His main purpose was to introduce Gossett suggests this will be a time for time to open our [advertisers] eyes." communication. and open the field of advertising to businesses to become familiar with This comment sends a positive message Earlier in the semester an entire day students who think they are interested, students. And a time for students to of change and realization of how was planned for people interested in the but are not sure.
    [Show full text]
  • Sarah Kay H & H
    Culture El Gato • Friday January 31, 2014 •www.elgatonews.com 13 p m p Meet dynamic duo: m Sarah Kay h & h m Phil Kaye m m m m m m m m m m m M. Huang m by Michelle Huang m m m mysteries of life. Web Editor m m On Saturday, January 11, Sarah Kay and Phil Kaye came to the Children’s Creativ- Sarah Kay: “It started with a sweater.” ity Museum in San Francisco to perform. The audience buzzed with excitement and Phil Kaye: “I was looking incredibly fly. First day of college orientation as a freshman… anticipation as stage lights illuminated two empty microphones, waiting for two plus, I’m the type of a guy who’s always trying to make a good impression. tremendous demigods to appear. Sarah: “He looked like a tool.” Sarah and Phil stepped on stage to uproarious applause and immediately began The story of this incredibly good-looking, happa power-duo started backstage at a talent reciting an old classic. Throughout the rest of the night, the duo intertwined solo show, where Sarah noticed Phil’s “tool-ish” sweater. The very same sweater gave Phil the performances with duets, familiar poems with original ones, and witty banter that could courage to walk over and introduce himself to the beautiful girl with black curls. That night, have stood alone as comedy acts. Phil presented a completely new work, an ode written the two strangers bonded over the spoken word poetry they both presented at Brown University’s from the perspective of his old computer, much to the surprise of both the audience and talent show.
    [Show full text]
  • Songs by Artist
    TOTALLY TWISTED KARAOKE Songs by Artist 37 SONGS ADDED IN SEP 2021 Title Title (HED) PLANET EARTH 2 CHAINZ, DRAKE & QUAVO (DUET) BARTENDER BIGGER THAN YOU (EXPLICIT) 10 YEARS 2 CHAINZ, KENDRICK LAMAR, A$AP, ROCKY & BEAUTIFUL DRAKE THROUGH THE IRIS FUCKIN PROBLEMS (EXPLICIT) WASTELAND 2 EVISA 10,000 MANIACS OH LA LA LA BECAUSE THE NIGHT 2 LIVE CREW CANDY EVERYBODY WANTS ME SO HORNY LIKE THE WEATHER WE WANT SOME PUSSY MORE THAN THIS 2 PAC THESE ARE THE DAYS CALIFORNIA LOVE (ORIGINAL VERSION) TROUBLE ME CHANGES 10CC DEAR MAMA DREADLOCK HOLIDAY HOW DO U WANT IT I'M NOT IN LOVE I GET AROUND RUBBER BULLETS SO MANY TEARS THINGS WE DO FOR LOVE, THE UNTIL THE END OF TIME (RADIO VERSION) WALL STREET SHUFFLE 2 PAC & ELTON JOHN 112 GHETTO GOSPEL DANCE WITH ME (RADIO VERSION) 2 PAC & EMINEM PEACHES AND CREAM ONE DAY AT A TIME PEACHES AND CREAM (RADIO VERSION) 2 PAC & ERIC WILLIAMS (DUET) 112 & LUDACRIS DO FOR LOVE HOT & WET 2 PAC, DR DRE & ROGER TROUTMAN (DUET) 12 GAUGE CALIFORNIA LOVE DUNKIE BUTT CALIFORNIA LOVE (REMIX) 12 STONES 2 PISTOLS & RAY J CRASH YOU KNOW ME FAR AWAY 2 UNLIMITED WAY I FEEL NO LIMITS WE ARE ONE 20 FINGERS 1910 FRUITGUM CO SHORT 1, 2, 3 RED LIGHT 21 SAVAGE, OFFSET, METRO BOOMIN & TRAVIS SIMON SAYS SCOTT (DUET) 1975, THE GHOSTFACE KILLERS (EXPLICIT) SOUND, THE 21ST CENTURY GIRLS TOOTIMETOOTIMETOOTIME 21ST CENTURY GIRLS 1999 MAN UNITED SQUAD 220 KID X BILLEN TED REMIX LIFT IT HIGH (ALL ABOUT BELIEF) WELLERMAN (SEA SHANTY) 2 24KGOLDN & IANN DIOR (DUET) WHERE MY GIRLS AT MOOD (EXPLICIT) 2 BROTHERS ON 4TH 2AM CLUB COME TAKE MY HAND
    [Show full text]
  • Souls of Mischief: ’93 Still Infinity Tour Hits Pawtucket
    Souls of Mischief: ’93 Still Infinity Tour Hits Pawtucket The Met played host to the Souls of Mischief during their 20-year anniversary tour of their legendary debut album, “’93 til Infinity”. This Oakland-based hip- hop group, comprised of four life-long friends, A-Plus, Tajai, Opio and Phesto, together has created one of the most influential anthems of the ‘90’s hip-hop movement: the title track of the album, ’93 ‘til Infinity. This song is a timeless classic. It has a simple, but beautifully melodic beat that works seamlessly with the song’s message of promoting peace, friendship and of course, chillin’. A perfect message to kick off a summer of music with. The crowd early on in the night was pretty thin and the supporting acts did their best to amp up the audience for the Souls of Mischief. When they took the stage at midnight, the shift in energy was astounding. They walked out on stage and the waning crowd filled the room in seconds. The group was completely unfazed by the relatively small showing and instead, connected with the crowd and how excited they were to be in Pawtucket, RI of all places. Tajai, specifically, reminisced about his youth and his precious G.I. Joes (made by Hasbro) coming from someplace called Pawtucket and how “souped” he was to finally come through. The show was a blissful ride through the group’s history, mixing classic tracks like “Cab Fare” with more recent releases, like “Tour Stories”. The four emcees seamlessly passed around the mic and to the crowd’s enjoyment, dropped a song from their well-known hip-hop super-group, Hieroglyphics, which includes the likes of Casual, Del Tha Funkee Homosapien and more.
    [Show full text]
  • Pep Love the Foundation Mp3, Flac, Wma
    Pep Love The Foundation mp3, flac, wma DOWNLOAD LINKS (Clickable) Genre: Hip hop Album: The Foundation Released: 2013 Style: Conscious MP3 version RAR size: 1675 mb FLAC version RAR size: 1282 mb WMA version RAR size: 1191 mb Rating: 4.1 Votes: 764 Other Formats: DTS VOC MP1 MOD MP4 AAC DMF Tracklist Hide Credits 1 –DJ Icewater Intro 0:50 2 –Pep Love Lean Back 1:22 After Dark 3 –Hieroglyphics 1:58 Producer [Uncredited] – Domino Wait A Minute 4 –Bicasso 1:30 Producer [Uncredited] – Bicasso 5 –Pep Love On Fire 1:13 You Never Knew (Domino Remix) 6 –Hieroglyphics Remix [Uncredited] – Domino Scratches [Uncredited] – Jay- 1:16 Biz Da Monkey 7 –Casual Featuring [Uncredited] – Kwame Allah, TajaiProducer 1:03 [Uncredited] – Casual See Delight 8 –Hieroglyphics 1:11 Producer [Uncredited] – Opio Warriors Dance 9 –Zion I Producer [Uncredited] – 418 HZ ProductionsVocals 1:56 [Uncredited] – Jog9 10 –Pep Love Hyphy 1:22 Soweto 11 –Hieroglyphics 0:45 Producer [Uncredited] – A-PlusVocals [Uncredited] – Goapele Dang Diggy 12 –Casual Featuring [Uncredited] – Planet AsiaProducer [Uncredited] – 1:29 Casual –Aceyalone, Ahmad & Pep 13 Give It Here 0:59 Love All Things 14 –Hieroglyphics 1:39 Producer [Uncredited] – Domino Got It Twisted 15 –Pep Love 1:26 Featuring [Uncredited] – Ty Knitty Do Not Touch 16 –Tajai 1:18 Producer [Uncredited] – Domino City Livin' 17 –Encore 1:15 Producer [Uncredited] – Architect The Undisputed Champs –Del Tha Funkee 18 Featuring [Uncredited] – Q-TipProducer [Uncredited] – Del 3:08 Homosapien Tha Funkee Homosapien Selfish 19 –Pep Love 4:22 Featuring [Uncredited] – JC Ease Your Mind 20 –Goapele 3:46 Producer [Uncredited] – Johnson Credits DJ Mix – DJ Icewater DJ Mix [Featuring] – JC , New Being, Ty-Stick* Featuring [Uncredited] – Pep Love (tracks: 4, 7, 9, 12, 16 to 18, 20) Notes 2.
    [Show full text]
  • GET 56017 SOULS of MISCHIEF 93 Til Infinity CD
    Souls Of Mischief Music Book DISC ONE DISC TWO 1. Let ‘Em Know 1. 93 ‘Til Infinity (12” Remix Version) 2. Live And Let Live 2. That’s When Ya Lost (I Ain’t Trippin’ Remix) 3. That’s When Ya Lost 3. Make Your Mind Up (Rock On Mix) 4. A Name I Call Myself 4. Never No More (76 Seville Mix) 5. Disseshowedo 5. Good Feeling (12” Version) 6. What A Way To Go Out 6. 93 ‘Til Infinity (LP Instrumental) 7. Never No More 7. 93 ’Til Infinity (Remix Instrumental) 8. 93 ‘Til Infinity 8. That’s When Ya Lost (LP Instrumental) 9. Limitations 9. Never No More (LP Instrumental) 10. Anything Can Happen 10. Never No More (76 Seville Mix Instrumental) 11. Make Your Mind Up 11. 93 ‘Til Infinity (Acapella Version) 12. Batting Practice 13. Tell Me Who Profits 14. Outro In the year of its 20th anniversary Get On Down revisits an unassailable classic: Souls of Mischief’s 93 ‘til Infinity. Reissued for the first time as a 2 CD set, Get On Down’s deluxe version of this Souls Of Mischief’s classic features the original album, as well as bonus remixes and instrumentals all bundled in a 36-page case book filled with art elements, liner notes, and interviews. The book even plays a clip from the title track when opened! Consisting of MCs A+, Phesto, Opio and Tajai (with production by A+, Domino, Del the Funky Homosapien, Jay Biz and Casual), East Oakland’s Souls of Mischief burst onto the scene in the early ‘90s with an impact that few other West Coast artists had at the time.
    [Show full text]
  • Opio Triangulation Station Mp3, Flac, Wma
    Opio Triangulation Station mp3, flac, wma DOWNLOAD LINKS (Clickable) Genre: Hip hop Album: Triangulation Station Country: US Released: 2005 MP3 version RAR size: 1921 mb FLAC version RAR size: 1420 mb WMA version RAR size: 1315 mb Rating: 4.3 Votes: 597 Other Formats: FLAC VOC XM RA AUD MMF AU Tracklist Hide Credits Viva Main Vein!!! 1 Featuring – Roc RaidaProducer – OpioScratches – Roc RaidaWritten-By – Opio Dream...But Don't Sleep 2 Bass – Merlo PodlewskiProducer – OpioVocals – Amp FiddlerWritten-By – Opio Confederate Burning 3 Featuring – Casual, Rasco, Roc RaidaProducer – Domino Scratches – Roc RaidaWritten-By – Casual, Domino , Opio, Rasco Things Do Change 4 Featuring – A-Plus, Shake The Mayor*Producer – OpioVocals – Amp FiddlerWritten-By – Opio Fist Full 5 Featuring – A-PlusProducer – A-PlusWritten-By – A-Plus, Opio Granite Earth 6 Featuring – Pigeon JohnKeyboards, Bass – Amp FiddlerProducer – OpioWritten-By – Opio, Pigeon John What's Wrong With This Picture 7 Featuring – Del The FunkyHomosapien*Keyboards – Amp FiddlerProducer – OpioScratches – ToureWritten-By – Del The FunkyHomosapien*, Opio Take My Chances 8 Producer – OpioVocals, Bass, Keyboards – Amp FiddlerWritten-By – Opio Roxanna 9 Guitar – Eric McFaddenProducer – OpioVocals, Bass – Amp FiddlerWritten-By – Opio For Those Who Don't Know 10 Producer – OpioScratches – ToureWritten-By – Opio Mind, Body, And Soul 11 Producer – Bootie BrownScratches – ToureWritten-By – Bootie Brown, Opio Drivers Wanted 12 Featuring – Souls Of MischiefProducer – OpioWritten-By – A-Plus, Opio, Phesto, Tajai Talk Dirty 13 Featuring – Pep Love, Persia Producer – A-PlusWritten-By – A-Plus, Opio, Pep Love Perserverance 14 Producer – OpioWritten-By – Opio Soundtrack To My Thought Process 15 Bass – Amp FiddlerProducer – OpioWritten-By – Opio The Grassy Knoll 16 Featuring – Planet AsiaProducer – OpioWritten-By – Opio, Planet Asia Puppet On A String 17 Producer – OpioWritten-By – Opio Companies, etc.
    [Show full text]