University of Nebraska Medical Center DigitalCommons@UNMC Theses & Dissertations Graduate Studies Spring 5-4-2019 Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention Nathan Smith University of Nebraska Medical Center Follow this and additional works at: https://digitalcommons.unmc.edu/etd Part of the Nanomedicine Commons Recommended Citation Smith, Nathan, "Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention" (2019). Theses & Dissertations. 354. https://digitalcommons.unmc.edu/etd/354 This Dissertation is brought to you for free and open access by the Graduate Studies at DigitalCommons@UNMC. It has been accepted for inclusion in Theses & Dissertations by an authorized administrator of DigitalCommons@UNMC. For more information, please contact
[email protected]. Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention by Nathan Smith A Dissertation Presented to the Faculty of the University of Nebraska Medical Center Graduate College in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Medical Sciences Interdepartmental Area Specialization: Pharmacology and Experimental Neuroscience Under the Supervision of Dr. Howard E. Gendelman University of Nebraska Medical Center Omaha, Nebraska April, 2019 Supervisory Committee: Dr. Howard E. Gendelman, M.D. Dr. Larisa Poluektova, M.D., Ph.D. Dr. JoEllyn McMillan, Ph.D Dr. David Oupicky, Ph.D. Dr. Laura Bilek, PT, Ph.D. Long-Acting Nanoformulated Small Molecule Inhibitor Prodrugs for Antiviral Treatment and Prevention Nathan Smith University of Nebraska Medical Center, 2019 Supervisor: Howard E. Gendelman, M.D. Abstract Over 30 years of antiretroviral therapy (ART) has transformed human immunodeficiency virus type one (HIV-1) outcomes from certain death to a nearly complete and normal life [1].