View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Dispatch R165 cytokinesis and are enhanced by Rho 18. Yamada, T., Hikida, M., and Kurosaki, T. (2006). and RGA-4 in the germ line and in the early and suppressed by Rac. J. Cell Biol. 166, Regulation of cytokinesis by mgcRacGAP in B embryo of C. elegans. Development 134, 61–71. lymphocytes is independent of GAP activity. 3495–3505. 16. Severson, A.F., Baillie, D.L., and Bowerman, B. Exp. Cell Res. 312, 3517–3525. (2002). A formin homology protein and a 19. Schonegg, S., Constantinescu, A.T., Hoege, C., profilin are required for cytokinesis and and Hyman, A.A. (2007). The Rho GTPase- Department of Molecular Genetics and Cell Arp2/3-independent assembly of cortical activating proteins RGA-3 and RGA-4 are Biology, University of Chicago, Chicago, microfilaments in C. elegans. Curr. Biol. 12, required to set the initial size of PAR domains IL 60637, USA. 2066–2075. in Caenorhabditis elegans one-cell E-mail:
[email protected] 17. Zhang, W., and Robinson, D.N. (2005). Balance embryos. Proc. Natl. Acad. Sci. USA of actively generated contractile and resistive 104, 14976–14981. forces controls cytokinesis dynamics. Proc. 20. Schmutz, C., Stevens, J., and Spang, A. (2007). Natl. Acad. Sci. USA 102, 7186–7191. Functions of the novel RhoGAP proteins RGA-3 DOI: 10.1016/j.cub.2008.12.028 Evolution: Revisiting the Root of the been controversial since they were first proposed [6]. Now, with the Eukaryote Tree rapid accumulation of genome-scale data for diverse protist species, a flurry of phylogenomic analyses A recent phylogenomic investigation shows that the enigmatic flagellate [7–9] are putting these hypotheses Breviata is a distinct anaerobic lineage within the eukaryote super-group to the test.