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Sleuths BEHIND the Scenes for PATHOLOGISTS, the UNUSUAL IS the USUAL
ON THE COVER sleuths BEHIND THE scenes FOR PATHOLOGISTS, THE UNUSUAL IS THE USUAL. BY HOWARD BELL ennifer Boland’s path to pathology began during her sec- ond year of medical school at Washington University in St. Louis. Boland would take study breaks by looking at Jspecimen slides and images, learning to identify them. “Pathology is a visual science. I found it more enjoyable than memorizing notes,” she recalls. After a surgical pathology elective during her clinical rotations, she was hooked. “In medicine it can be hard to find the field you love,” says Boland, who is now a pathologist at Mayo Clinic. “I was lucky enough to find it.” Boland began practicing at Mayo three years ago, after com- pleting a pathology residency as well as pulmonary and surgical pathology fellowships there. She specializes in pulmonary and bone and soft-tissue pathology. Her particular expertise is in lung and chest sarcomas. “They’re a rare and interesting set of tumors,” she says. “Very few are diagnosed in this country each year.” Like many Mayo pathologists, she spends about half her time evaluating specimens from around the world for Mayo Medical Laboratories and the other half evaluating specimens from Mayo patients. Depending on case complexity, she evaluates around 25 to 50 specimens each day. “I like the mystery-solving of pathol- ogy,” she says. Boland is one of 332 pathologists who practice in Minnesota, according to the Minnesota Board of Medical Practice. Often thought of as either white-coated geeks hunched over microscopes or sexy swashbucklers who spend more time solving crimes than analyzing specimens (thanks to TV), pathologists 20 | MINNESOTA MEDICINE | OCTOBER 2014 ON THE COVER OCTOBER 2014 | MINNESOTA MEDICINE | 21 ON THE COVER are sleuths working behind the scenes to ogy, Boland says, adding that many don’t years for neuropathology). -
Job Posting Clinical Microbiology Final
The Department of Pathology & Cell Biology at Columbia University Irving Medical Center (CUIMC) is recruiting for an MD, MD/PhD, or PhD academic clinical microbiologist of any rank to join our faculty as a Medical Director of the NewYork-Presbyterian/CUIMC Clinical Microbiology Laboratory. Applicants should have an established track record of accomplishment within the field of clinical microbiology and a demonstrated ability to lead an experienced group of laboratory technologists, supervisors, and staff. In addition to strong clinical and technical skills, particular emphasis is placed on candidates with a demonstrated record of collegiality and inter-departmental collaboration. Applicants must have completed a fellowship in clinical microbiology and be board-certified/board-eligible in Medical and Public Health Microbiology through the American Board of Medical Microbiology (ABMM) or board-certified/board- eligible in Clinical Pathology with subspecialty certification in Medical Microbiology through the American Board of Pathology (ABP). The applicant must also be able to satify clinical licensing requirements to serve as a Laboratory Director in New York State. The successful applicant will help oversee diagnostic testing in the areas of Bacteriology, Virology, Mycobacteriology, Mycology, and Parasitology. The position also includes responsibilities for teaching of pathology residents, medical students, infectious diseases fellows, and technical staff. Applicants must be currently involved in ongoing research with a track record of publications in the field. The position offers a competitive salary commensurate with training and experience, and an appointment to the faculty of the Columbia University Vagelos College of Physicians & Surgeons. The Clinical Microbiology Laboratory at NewYork-Presbyterian/CUIMC is located in the Washington Heights neighborhood of New York City, offering unparalleled opportunities to work and live in a thriving, diverse, metropolitan environment with access to world-class cultural institutions, restaurants, and entertainment. -
Medicolegal Death Investigation Forensic Pathology: Forensic
Medicolegal Death Investigation Forensic Pathology: Forensic pathology is a specific practice of medicine and subspecialty of pathology that directs its efforts to the examination of dead persons (and sometimes live persons) to provide an opinion concerning the: • cause, mechanism, and manner of disease, injury, or death; • identification of persons; • significance of biological and physical evidence; • correlation and/or reconstruction of wounds, wound patterns, and sequences. Forensic pathology is an integral component of comprehensive medicolegal death investigation. Forensic pathology applies techniques of pathology to the needs and protection of public health, Homeland Security (surveillance and mass disaster operations), public safety, quality assurance, education in medicine, research, jurisprudence, and the administration of justice. The highest goal of forensic pathology is the development of strategies to prevent injury, disease, and death. Forensic Pathologists: Forensic pathologists should be physicians specially trained in forensic pathology and board-certified by the American Board of Pathology or a non- USA trained pathologist with equivalent certification. The practicing forensic pathologist is licensed as a physician in one or more states and is skilled in conducting death investigations, interpreting injuries in both fatal and non-fatal cases, performing medicolegal examinations, determining disease/injury causation to an appropriate degree of medical certainty, and determining cause and manner of death. Forensic pathologists -
Cytomegalovirus Retinitis: a Manifestation of the Acquired Immune Deficiency Syndrome (AIDS)*
Br J Ophthalmol: first published as 10.1136/bjo.67.6.372 on 1 June 1983. Downloaded from British Journal ofOphthalmology, 1983, 67, 372-380 Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS)* ALAN H. FRIEDMAN,' JUAN ORELLANA,'2 WILLIAM R. FREEMAN,3 MAURICE H. LUNTZ,2 MICHAEL B. STARR,3 MICHAEL L. TAPPER,4 ILYA SPIGLAND,s HEIDRUN ROTTERDAM,' RICARDO MESA TEJADA,8 SUSAN BRAUNHUT,8 DONNA MILDVAN,6 AND USHA MATHUR6 From the 2Departments ofOphthalmology and 6Medicine (Infectious Disease), Beth Israel Medical Center; 3Ophthalmology, "Medicine (Infectious Disease), and 'Pathology, Lenox Hill Hospital; 'Ophthalmology, Mount Sinai School ofMedicine; 'Division of Virology, Montefiore Hospital and Medical Center; and the 8Institute for Cancer Research, Columbia University College ofPhysicians and Surgeons, New York, USA SUMMARY Two homosexual males with the 'gay bowel syndrome' experienced an acute unilateral loss of vision. Both patients had white intraretinal lesions, which became confluent. One of the cases had a depressed cell-mediated immunity; both patients ultimately died after a prolonged illness. In one patient cytomegalovirus was cultured from a vitreous biopsy. Autopsy revealed disseminated cytomegalovirus in both patients. Widespread retinal necrosis was evident, with typical nuclear and cytoplasmic inclusions of cytomegalovirus. Electron microscopy showed herpes virus, while immunoperoxidase techniques showed cytomegalovirus. The altered cell-mediated response present in homosexual patients may be responsible for the clinical syndromes of Kaposi's sarcoma and opportunistic infection by Pneumocystis carinii, herpes simplex, or cytomegalovirus. http://bjo.bmj.com/ Retinal involvement in adult cytomegalic inclusion manifestations of the syndrome include the 'gay disease (CID) is usually associated with the con- bowel syndrome9 and Kaposi's sarcoma. -
DUKE UNIVERSITY School of Medicine Pathologists' Assistant
DUKE UNIVERSITY School of Medicine Pathologists’ Assistant Program Department of Pathology Academic Programs The Department of Pathology at Duke University offers a wide array of training programs to fit individual requirements and goals. The Residency Training program is an ACGME approved program and is available as an Anatomic Pathology/Clinical Pathology combined program, a shorter Anatomic Pathology only program, or an Anatomic Pathology/Neuropathology program. Subspecialty fellowships in Cytopathology, Dermatopathology, Hematopathology, Medical Microbiology, and Neuropathology are also ACGME approved. These programs provide the highest quality of graduate medical education by drawing on the depth and breadth of faculty expertise in the Department in all aspects of anatomic and clinical pathology and the availability of a wide variety of often complex clinical cases seen at Duke University Health System. For medical students interested in a career in Pathology pre-doctoral fellowships, internships and externships are available. Research Training in Experimental pathology can be obtained through Pre- and postdoctoral fellowships of one to five years. All pre-doctoral fellows are candidates for the Ph.D. degree in pathology. The Ph.D. is optional in postdoctoral programs, which provide didactic and research training in various aspects of modern experimental pathology. A two year NAACLS accredited Pathologists’ Assistant Program leads to a Master of Health Science degree, certifies graduates to sit for the ASCP Board of Certification examination, and leads to exciting career opportunities in a variety of anatomic pathology laboratory settings. Pathologists’ assistants are analogous to physician assistants, but with highly specialized training in autopsy and surgical pathology. This profession was pioneered in the Duke Department of Pathology 50 years ago, and is one of only twelve such programs in existence today. -
Anatomic Pathology Checklist
Master Every patient deserves the GOLD STANDARD ... Anatomic Pathology Checklist CAP Accreditation Program College of American Pathologists 325 Waukegan Road Northfield, IL 60093-2750 www.cap.org 04.21.2014 2 of 71 Anatomic Pathology Checklist 04.21.2014 Disclaimer and Copyright Notice On-site inspections are performed with the edition of the Checklists mailed to a facility at the completion of the application or reapplication process, not necessarily those currently posted on the Web site. The checklists undergo regular revision and a new edition may be published after the inspection materials are sent. For questions about the use of the Checklists or Checklist interpretation, email [email protected] or call 800-323-4040 or 847-832-7000 (international customers, use country code 001). The Checklists used for inspection by the College of American Pathologists' Accreditation Programs have been created by the CAP and are copyrighted works of the CAP. The CAP has authorized copying and use of the checklists by CAP inspectors in conducting laboratory inspections for the Commission on Laboratory Accreditation and by laboratories that are preparing for such inspections. Except as permitted by section 107 of the Copyright Act, 17 U.S.C. sec. 107, any other use of the Checklists constitutes infringement of the CAP's copyrights in the Checklists.The CAP will take appropriate legal action to protect these copyrights. All Checklists are ©2014. College of American Pathologists. All rights reserved. 3 of 71 Anatomic Pathology Checklist 04.21.2014 Anatomic -
Printable Version
Clinical Pathology Laboratories Drugs of Abuse Testing Offering our clients state-of-the-art testing is part of CPL’s ongoing commitment to excellence. Effective 06/18/2018, Clinical Pathology Laboratories (CPL) will replace current drug of abuse (DAU) screening and screening with reflex confirmation profiles. The new profiles provide: • Reformulation and recombination of classes for profile testing, more relevant to current societal trends • Standardization of drug thresholds to high sensitivity cutoff values • Addition of the following analytes in specific profiles for testing: o Fentanyl o Buprenorphine o 6-Acetylmorphine o MDMA (Ecstasy) • Expansion of testing for adulterants with disqualifying comments added to specimens determined to be altered • Expansion of interpretive notes on reports regarding the method, cutoff values, and specific drugs that may or may not be detected by the screening method New Profile Name EtOH Opiates Cocaine Fentanyl Oxycodone Order Code Methadone Barbiturates Cannabinoids Phencyclidine Acetylmorphine Buprenorphine Amphetamines MDMA/Ecstasy - Benzodiazepines 6 Drug of Abuse, 8 Analytes 3305 X X X X X X X X No Confirm Drug of Abuse, 8 Analytes 3306 X X X X X X X X w/ Confirm Drug of Abuse, 9 Analytes 3316 X X X X X X X X X w/ EtOH, No Confirm Drug of Abuse, 9 Analytes 3315 X X X X X X X X X w/ EtOH, w/ Confirm Drug of Abuse, 9 Analytes 3307 X X X X X X X X X No THC or Confirm Drug of Abuse, 9 Analytes 3308 X X X X X X X X X No THC, w/ Confirm Drug of Abuse, 10 Analytes 3317 X X X X X X X X X X No Confirm -
Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: a Review
pathogens Review Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: A Review Onyinyechukwu Ada Agina 1,2,* , Mohd Rosly Shaari 3, Nur Mahiza Md Isa 1, Mokrish Ajat 4, Mohd Zamri-Saad 5 and Hazilawati Hamzah 1,* 1 Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Malaysia; [email protected] 2 Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Nsukka 410001, Nigeria 3 Animal Science Research Centre, Malaysian Agricultural Research and Development Institute, Headquarters, Serdang 43400, Malaysia; [email protected] 4 Department of Veterinary Pre-clinical sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Malaysia; [email protected] 5 Research Centre for Ruminant Diseases, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Malaysia; [email protected] * Correspondence: [email protected] (O.A.A.); [email protected] (H.H.); Tel.: +60-11-352-01215 (O.A.A.); +60-19-284-6897 (H.H.) Received: 2 May 2020; Accepted: 16 July 2020; Published: 25 August 2020 Abstract: Theileriosis is a blood piroplasmic disease that adversely affects the livestock industry, especially in tropical and sub-tropical countries. It is caused by haemoprotozoan of the Theileria genus, transmitted by hard ticks and which possesses a complex life cycle. The clinical course of the disease ranges from benign to lethal, but subclinical infections can occur depending on the infecting Theileria species. The main clinical and clinicopathological manifestations of acute disease include fever, lymphadenopathy, anorexia and severe loss of condition, conjunctivitis, and pale mucous membranes that are associated with Theileria-induced immune-mediated haemolytic anaemia and/or non-regenerative anaemia. -
Curated Materials
PATHOLOGY RESOURCES TO DOWNLOAD Looking for more information or mentorship in Pathology? Send an email to: [email protected] for announcements on future pathology open houses hosted by the APC! QUICK LINKS TO DOWNLOAD: PDF RESOURCES WITH MORE LINKS! • Follow Pathology & Pathologists: www.dropbox.com/s/olq2dvuptrxcgli/Pathology_People%2BOrganizations.pdf?dl=0 • Watch Pathology Videos: www.dropbox.com/s/jor8en7g1y4soaf/Pathology_VideosToWatch.pdf?dl=0 • Free Memberships & Awards: www.dropbox.com/s/6erz3nh2ndngi16/Pathology_StudentOpportunities.pdf?dl=0 OTHER DOWNLOADABLE PDF RESOURCES ABOUT PATHOLOGY • Top 5 Pathology Myth Busted Flier (cap.org) https://documents.cap.org/documents/pathology-five-myths-busted-flier.pdf • Pathology 101 for Medical Students (cap.org) https://documents.cap.org/documents/pathology-101-for-medical-students.pdf • Overview of Anatomic and Clinical Pathology (cap.org) https://documents.cap.org/documents/overview-anatomic-clinical-pathology-medical-students.pdf • The Road to Becoming a Biomedical Physician Scientist (asip.org) www.asip.org/ASIP/assets/file/careers/TheRoad.pdf SALARIES, JOB MARKET, WORKFORCE TRENDS, AND CAREERS IN PATHOLOGY From APC’s Journal – Academic Pathology • Pathology: A Satisfying Medical Profession: journals.sagepub.com/doi/full/10.1177/2374289516661559 • Opportunity: Newly Created Physician-Scientist Research Pathway by the American Board of Pathology: journals.sagepub.com/doi/full/10.1177/2374289516632240 • The Pathology Workforce and Clinical Licensure: The Role of the PhD Clinical Laboratorian in the United States: journals.sagepub.com/doi/full/10.1177/2374289518775948 • Entry of Graduates of US Pathology Residency Programs Into the Workforce: Cohort Data Between 2008 and 2016 Remain Positive and Stable: journals.sagepub.com/doi/10.1177/2374289520901833 From ASCP’s Magazine – The Pathologist • Dr. -
Overview of Pathology and Its Related Disciplines - Soheir Mahmoud Mahfouz
MEDICAL SCIENCES – Vol.I -Overview of Pathology and its Related Disciplines - Soheir Mahmoud Mahfouz OVERVIEW OF PATHOLOGY AND ITS RELATED DISCIPLINES Soheir Mahmoud Mahfouz Cairo University, Kasr El Ainy Hospital, Egypt Keywords: Pathology, Pathology disciplines, Pathology techniques, Ancillary diagnostic methods, General Pathology, Special Pathology Contents 1. Introduction 1.1 Pathology coverage 1.1.1 Etiology and Pathogenesis of a Disease 1.1.2 Manifestations of Disease (Lesions) 1.1.3 Phases Of A Disease Process (Course) 1.2 Physician’s approach to patient 1.3 Types of pathologists and affiliated specialties 1.4 Role of pathologist 2. Pathology and its related disciplines 2.1 Cytology 2.1.1 Cytology Samples 2.1.2 Technical Aspects 2.1.3 Examination of Sample and Diagnosis 3. Pathology techniques and ancillary diagnostic methods 3.1 Macroscopic pathology 3.2 Light Microscopy 3.3 Polarizing light microscopy 3.4 Electron microscopy (EM) 3.5 Confocal Microscopy 3.6 Frozen section 3.7 Cyto/histochemistry 3.8 Immunocyto/histochemical methods 3.9 Molecular and genetic methods of diagnosis 3.10 Quantitative methods 4. Types of tests used in pathology 4.1 DiagnosticUNESCO tests – EOLSS 4.2 Quantitative tests 4.3 Prognostic tests 5. The scope of SAMPLEpathology & its main divisions CHAPTERS 6. Conclusions Glossary Bibliography Biographical sketch Summary Pathology is the science of disease. It deals with deviations from normal body function and ©Encyclopedia of Life Support Systems (EOLSS) MEDICAL SCIENCES – Vol.I -Overview of Pathology and its Related Disciplines - Soheir Mahmoud Mahfouz structure. Many disciplines are involved in the study of disease, as it is necessary to understand the complex causes and effects of various disorders that affect the organs and body as a whole. -
Head and Neck Specimens
Head and Neck Specimens DEFINITIONS AND GENERAL COMMENTS: All specimens, even of the same type, are unique, and this is particularly true for Head and Neck specimens. Thus, while this outline is meant to provide a guide to grossing the common head and neck specimens at UAB, it is not all inclusive and will not capture every scenario. Thus, careful assessment of each specimen with some modifications of what follows below may be needed on a case by case basis. When in doubt always consult with a PA, Chief/Senior Resident and/or the Head and Neck Pathologist on service. Specimen-derived margin: A margin taken directly from the main specimen-either a shave or radial. Tumor bed margin: A piece of tissue taken from the operative bed after the main specimen has been resected. This entire piece of tissue may represent the margin, or it could also be specifically oriented-check specimen label/requisition for any further orientation. Margin status as determined from specimen-derived margins has been shown to better predict local recurrence as compared to tumor bed margins (Surgical Pathology Clinics. 2017; 10: 1-14). At UAB, both methods are employed. Note to grosser: However, even if a surgeon submits tumor bed margins separately, the grosser must still sample the specimen margins. Figure 1: Shave vs radial (perpendicular) margin: Figure adapted from Surgical Pathology Clinics. 2017; 10: 1-14): Red lines: radial section (perpendicular) of margin Blue line: Shave of margin Comparison of shave and radial margins (Table 1 from Chiosea SI. Intraoperative Margin Assessment in Early Oral Squamous Cell Carcinoma. -
American Society for Clinical Pathology to the Clinical Laboratory Improvement Advisory Committee
Statement from the American Society for Clinical Pathology to the Clinical Laboratory Improvement Advisory Committee The American Society for Clinical Pathology is pleased to provide this statement to the Clinical Laboratory Improvement Advisory Committee (CLIAC) on the roles, responsibilities and competencies of bioinformaticists. The completion of the Human Genome Project has resulted in vast sums of patient data, and bioinformaticists are increasingly being utilized by clinical laboratories to manage, process, and analyze it, especially in the rapidly expanding specialty of molecular diagnostics. Bioinformaticists, and the unique skills these individuals bring, are also helping to transform the practice of pathology and laboratory medicine by developing or/or enhancing the bioinformatics tools used to expand the ability of pathology and laboratory medicine to protect patient health. ASCP greatly appreciates CLIAC’s leadership by focusing attention on the valuable contribution these professionals are making and to improve their ability to do so. The following comments are based on comments provided by our membership during our efforts to respond to the questions posed by the CLIAC. CLIAC Discussion Questions: Question 1: Are Bioinformaticists needed in clinical and public health laboratories? If so, what are the current roles, responsibilities, and competencies of bioinformaticists in these settings? ASCP believes that bioinformaticists are a key component of high quality, full service clinical laboratories, though the roles and responsibilities of these professionals may vary significantly. Informaticists are critical to building the bioinformatics pipeline, which can include the software and database engineering, configuration of available bioinformatics software, and/or management and interfacing of LIS and other informatics systems, both internally within the laboratory (e.g.