DUKE UNIVERSITY School of Medicine Pathologists' Assistant
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Sleuths BEHIND the Scenes for PATHOLOGISTS, the UNUSUAL IS the USUAL
ON THE COVER sleuths BEHIND THE scenes FOR PATHOLOGISTS, THE UNUSUAL IS THE USUAL. BY HOWARD BELL ennifer Boland’s path to pathology began during her sec- ond year of medical school at Washington University in St. Louis. Boland would take study breaks by looking at Jspecimen slides and images, learning to identify them. “Pathology is a visual science. I found it more enjoyable than memorizing notes,” she recalls. After a surgical pathology elective during her clinical rotations, she was hooked. “In medicine it can be hard to find the field you love,” says Boland, who is now a pathologist at Mayo Clinic. “I was lucky enough to find it.” Boland began practicing at Mayo three years ago, after com- pleting a pathology residency as well as pulmonary and surgical pathology fellowships there. She specializes in pulmonary and bone and soft-tissue pathology. Her particular expertise is in lung and chest sarcomas. “They’re a rare and interesting set of tumors,” she says. “Very few are diagnosed in this country each year.” Like many Mayo pathologists, she spends about half her time evaluating specimens from around the world for Mayo Medical Laboratories and the other half evaluating specimens from Mayo patients. Depending on case complexity, she evaluates around 25 to 50 specimens each day. “I like the mystery-solving of pathol- ogy,” she says. Boland is one of 332 pathologists who practice in Minnesota, according to the Minnesota Board of Medical Practice. Often thought of as either white-coated geeks hunched over microscopes or sexy swashbucklers who spend more time solving crimes than analyzing specimens (thanks to TV), pathologists 20 | MINNESOTA MEDICINE | OCTOBER 2014 ON THE COVER OCTOBER 2014 | MINNESOTA MEDICINE | 21 ON THE COVER are sleuths working behind the scenes to ogy, Boland says, adding that many don’t years for neuropathology). -
Medicolegal Death Investigation Forensic Pathology: Forensic
Medicolegal Death Investigation Forensic Pathology: Forensic pathology is a specific practice of medicine and subspecialty of pathology that directs its efforts to the examination of dead persons (and sometimes live persons) to provide an opinion concerning the: • cause, mechanism, and manner of disease, injury, or death; • identification of persons; • significance of biological and physical evidence; • correlation and/or reconstruction of wounds, wound patterns, and sequences. Forensic pathology is an integral component of comprehensive medicolegal death investigation. Forensic pathology applies techniques of pathology to the needs and protection of public health, Homeland Security (surveillance and mass disaster operations), public safety, quality assurance, education in medicine, research, jurisprudence, and the administration of justice. The highest goal of forensic pathology is the development of strategies to prevent injury, disease, and death. Forensic Pathologists: Forensic pathologists should be physicians specially trained in forensic pathology and board-certified by the American Board of Pathology or a non- USA trained pathologist with equivalent certification. The practicing forensic pathologist is licensed as a physician in one or more states and is skilled in conducting death investigations, interpreting injuries in both fatal and non-fatal cases, performing medicolegal examinations, determining disease/injury causation to an appropriate degree of medical certainty, and determining cause and manner of death. Forensic pathologists -
Cytomegalovirus Retinitis: a Manifestation of the Acquired Immune Deficiency Syndrome (AIDS)*
Br J Ophthalmol: first published as 10.1136/bjo.67.6.372 on 1 June 1983. Downloaded from British Journal ofOphthalmology, 1983, 67, 372-380 Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS)* ALAN H. FRIEDMAN,' JUAN ORELLANA,'2 WILLIAM R. FREEMAN,3 MAURICE H. LUNTZ,2 MICHAEL B. STARR,3 MICHAEL L. TAPPER,4 ILYA SPIGLAND,s HEIDRUN ROTTERDAM,' RICARDO MESA TEJADA,8 SUSAN BRAUNHUT,8 DONNA MILDVAN,6 AND USHA MATHUR6 From the 2Departments ofOphthalmology and 6Medicine (Infectious Disease), Beth Israel Medical Center; 3Ophthalmology, "Medicine (Infectious Disease), and 'Pathology, Lenox Hill Hospital; 'Ophthalmology, Mount Sinai School ofMedicine; 'Division of Virology, Montefiore Hospital and Medical Center; and the 8Institute for Cancer Research, Columbia University College ofPhysicians and Surgeons, New York, USA SUMMARY Two homosexual males with the 'gay bowel syndrome' experienced an acute unilateral loss of vision. Both patients had white intraretinal lesions, which became confluent. One of the cases had a depressed cell-mediated immunity; both patients ultimately died after a prolonged illness. In one patient cytomegalovirus was cultured from a vitreous biopsy. Autopsy revealed disseminated cytomegalovirus in both patients. Widespread retinal necrosis was evident, with typical nuclear and cytoplasmic inclusions of cytomegalovirus. Electron microscopy showed herpes virus, while immunoperoxidase techniques showed cytomegalovirus. The altered cell-mediated response present in homosexual patients may be responsible for the clinical syndromes of Kaposi's sarcoma and opportunistic infection by Pneumocystis carinii, herpes simplex, or cytomegalovirus. http://bjo.bmj.com/ Retinal involvement in adult cytomegalic inclusion manifestations of the syndrome include the 'gay disease (CID) is usually associated with the con- bowel syndrome9 and Kaposi's sarcoma. -
DUKE UNIVERSITY School of Medicine Pathologists' Assistant
DUKE UNIVERSITY School of Medicine Pathologists’ Assistant Program Department of Pathology Academic Programs The Department of Pathology at Duke University offers a wide array of training programs to fit individual requirements and goals. The Residency Training program is an ACGME approved program and is available as an Anatomic Pathology/Clinical Pathology combined program, a shorter Anatomic Pathology only program, or an Anatomic Pathology/Neuropathology program. Subspecialty fellowships in Cytopathology, Dermatopathology, Hematopathology, Medical Microbiology, and Neuropathology are also ACGME approved. These programs provide the highest quality of graduate medical education by drawing on the depth and breadth of faculty expertise in the Department in all aspects of anatomic and clinical pathology and the availability of a wide variety of often complex clinical cases seen at Duke University Health System. For medical students interested in a career in Pathology pre-doctoral fellowships, internships and externships are available. Research Training in Experimental pathology can be obtained through Pre- and postdoctoral fellowships of one to five years. All pre-doctoral fellows are candidates for the Ph.D. degree in pathology. The Ph.D. is optional in postdoctoral programs, which provide didactic and research training in various aspects of modern experimental pathology. A two year NAACLS accredited Pathologists’ Assistant Program leads to a Master of Health Science degree, certifies graduates to sit for the ASCP Board of Certification examination, and leads to exciting career opportunities in a variety of anatomic pathology laboratory settings. Pathologists’ assistants are analogous to physician assistants, but with highly specialized training in autopsy and surgical pathology. This profession was pioneered in the Duke Department of Pathology 50 years ago, and is one of only twelve such programs in existence today. -
Anatomic Pathology Checklist
Master Every patient deserves the GOLD STANDARD ... Anatomic Pathology Checklist CAP Accreditation Program College of American Pathologists 325 Waukegan Road Northfield, IL 60093-2750 www.cap.org 04.21.2014 2 of 71 Anatomic Pathology Checklist 04.21.2014 Disclaimer and Copyright Notice On-site inspections are performed with the edition of the Checklists mailed to a facility at the completion of the application or reapplication process, not necessarily those currently posted on the Web site. The checklists undergo regular revision and a new edition may be published after the inspection materials are sent. For questions about the use of the Checklists or Checklist interpretation, email [email protected] or call 800-323-4040 or 847-832-7000 (international customers, use country code 001). The Checklists used for inspection by the College of American Pathologists' Accreditation Programs have been created by the CAP and are copyrighted works of the CAP. The CAP has authorized copying and use of the checklists by CAP inspectors in conducting laboratory inspections for the Commission on Laboratory Accreditation and by laboratories that are preparing for such inspections. Except as permitted by section 107 of the Copyright Act, 17 U.S.C. sec. 107, any other use of the Checklists constitutes infringement of the CAP's copyrights in the Checklists.The CAP will take appropriate legal action to protect these copyrights. All Checklists are ©2014. College of American Pathologists. All rights reserved. 3 of 71 Anatomic Pathology Checklist 04.21.2014 Anatomic -
Curated Materials
PATHOLOGY RESOURCES TO DOWNLOAD Looking for more information or mentorship in Pathology? Send an email to: [email protected] for announcements on future pathology open houses hosted by the APC! QUICK LINKS TO DOWNLOAD: PDF RESOURCES WITH MORE LINKS! • Follow Pathology & Pathologists: www.dropbox.com/s/olq2dvuptrxcgli/Pathology_People%2BOrganizations.pdf?dl=0 • Watch Pathology Videos: www.dropbox.com/s/jor8en7g1y4soaf/Pathology_VideosToWatch.pdf?dl=0 • Free Memberships & Awards: www.dropbox.com/s/6erz3nh2ndngi16/Pathology_StudentOpportunities.pdf?dl=0 OTHER DOWNLOADABLE PDF RESOURCES ABOUT PATHOLOGY • Top 5 Pathology Myth Busted Flier (cap.org) https://documents.cap.org/documents/pathology-five-myths-busted-flier.pdf • Pathology 101 for Medical Students (cap.org) https://documents.cap.org/documents/pathology-101-for-medical-students.pdf • Overview of Anatomic and Clinical Pathology (cap.org) https://documents.cap.org/documents/overview-anatomic-clinical-pathology-medical-students.pdf • The Road to Becoming a Biomedical Physician Scientist (asip.org) www.asip.org/ASIP/assets/file/careers/TheRoad.pdf SALARIES, JOB MARKET, WORKFORCE TRENDS, AND CAREERS IN PATHOLOGY From APC’s Journal – Academic Pathology • Pathology: A Satisfying Medical Profession: journals.sagepub.com/doi/full/10.1177/2374289516661559 • Opportunity: Newly Created Physician-Scientist Research Pathway by the American Board of Pathology: journals.sagepub.com/doi/full/10.1177/2374289516632240 • The Pathology Workforce and Clinical Licensure: The Role of the PhD Clinical Laboratorian in the United States: journals.sagepub.com/doi/full/10.1177/2374289518775948 • Entry of Graduates of US Pathology Residency Programs Into the Workforce: Cohort Data Between 2008 and 2016 Remain Positive and Stable: journals.sagepub.com/doi/10.1177/2374289520901833 From ASCP’s Magazine – The Pathologist • Dr. -
Head and Neck Specimens
Head and Neck Specimens DEFINITIONS AND GENERAL COMMENTS: All specimens, even of the same type, are unique, and this is particularly true for Head and Neck specimens. Thus, while this outline is meant to provide a guide to grossing the common head and neck specimens at UAB, it is not all inclusive and will not capture every scenario. Thus, careful assessment of each specimen with some modifications of what follows below may be needed on a case by case basis. When in doubt always consult with a PA, Chief/Senior Resident and/or the Head and Neck Pathologist on service. Specimen-derived margin: A margin taken directly from the main specimen-either a shave or radial. Tumor bed margin: A piece of tissue taken from the operative bed after the main specimen has been resected. This entire piece of tissue may represent the margin, or it could also be specifically oriented-check specimen label/requisition for any further orientation. Margin status as determined from specimen-derived margins has been shown to better predict local recurrence as compared to tumor bed margins (Surgical Pathology Clinics. 2017; 10: 1-14). At UAB, both methods are employed. Note to grosser: However, even if a surgeon submits tumor bed margins separately, the grosser must still sample the specimen margins. Figure 1: Shave vs radial (perpendicular) margin: Figure adapted from Surgical Pathology Clinics. 2017; 10: 1-14): Red lines: radial section (perpendicular) of margin Blue line: Shave of margin Comparison of shave and radial margins (Table 1 from Chiosea SI. Intraoperative Margin Assessment in Early Oral Squamous Cell Carcinoma. -
1 APPENDIX 5 PATHOLOGY 1. Handling and Gross Examination Of
APPENDIX 5 PATHOLOGY 1. Handling and gross examination of gastrointestinal and pancreatic NETs Specimen handling and gross examination should be performed according to the Royal College of Pathologists (RCPath) guidelines for carcinoma of these organs[1- 3] and the ENETS guidance.[4] 1.1 Specimen fixation The resection specimen should, when possible, be placed on ice immediately after removal and brought as soon as possible, fresh and unopened, to the pathology laboratory, where it should be placed in a large volume of formalin-based fixative. 1.2 Specimen dissection As outlined in the RCPath dataset for the reporting of gastroenteropancreatic NETs,[5] specimen dissection should be performed according to the RCPath guidelines for carcinomas of the respective organs.[1-3] In general, dissection of specimens from the tubular gastrointestinal tract is based on serial slicing of the intact, tumour-bearing segment of the specimen. Dissection of pancreatoduodenectomy specimens is based on axial slicing of the intact specimen. Non-peritonealised resection margins in colorectal surgical specimens or the circumferential (‘dissected’) margins of pancreatic specimens are painted with suitable markers to enable subsequent identification of margin involvement. 1.3 Macroscopic assessment The core macroscopic data to be included in the pathology report are the specimen type; the site and three-dimensional size of the tumour; extension of the tumour within the primary organ and into neighbouring tissues; relationship to other key anatomical structures and the specimen resection margins; and the number and site of lymph nodes retrieved from the main specimen and/or from separately submitted samples.[4, 5] 1 1.4 Tissue sampling Representative blocks should be taken from the tumour to demonstrate the deepest point of invasion and/or involvement of adjacent tissues or anatomical structures relevant to WHO classification[6, 7] and TNM staging schemes.[8-10] The closest transection and/or circumferential (‘dissected’) margin(s) should be sampled. -
Cinical Pathology and Molecular Pathology
Training Programme (essential elements) Clinical Practical Year (CPY) at Medical University of Vienna, Austria CPY‐Tertial C Cinical Pathology and Molecular Pathology Valid from academic year 2018/19 In charge of the content Univ. Prof. Renate Kain, MD, PhD This training programme applies to the subject of "Cinical Pathology and Molecular Pathology" within CPY tertial C "Electives". The training programmes for the elective subjects in CPY tertial C are each designed for a duration of 8 weeks. © 2018, Medical University of Vienna 07.06.2018 3. Learning objectives (competences) The following skills will be acquired during the CPY. 3.1 Competences to be achieved (mandatory) A) History taking 1. Evaluation of the clinical information necessary for preparing a pathological examination and if the necessary information is not available, initiating or generating collection of such information 2. Evaluation of the relevant findings from the case files/clinical notes to determine the cause of death 3. Interpretation and understanding of histopathological, immuno‐histochemical, molecular and cytological findings and/or autopsy findings B) Gross examination techniques 4. Macroscopic assessment, evaluation and description of sample material from all medical disciplines obtained by surgery, biopsy or fine needle aspiration 5. External description of the corpse C) Routine skills and procedures 6. Performing a surgical cut including gross examination, dissection and block selection 7. Preparing a surgical specimen for frozen section examination) 8. Familiarity with ordering a laboratory investigation for special stains and investigations e.g. immunohistochemical, histochemical, immunofluorescence and molecular tests, for diagnostic purposes 9. Evaluation of histological, immunohistochemical, molecular and cytological preparations 10. Identification and interpretation of pathological changes 11. -
AAPA Position on Utilization of Non-Pathologist Grossing Personnel in the Anatomic Pathology Laboratory
AAPA Position on Utilization of Non-Pathologist Grossing Personnel in the Anatomic Pathology Laboratory College of American Pathology (CAP) Qualifications for Gross Examination by Non-Pathologist If individuals other than a pathologist or pathology resident assist in gross examinations, such individuals qualify as high complexity testing personnel. (Reference: CAP Anatomic Pathology Checklist item ANP.11610 Gross Examination – High Complexity Testing Qualifications, 06/04/2020) NOTE: Grossing is defined as a tissue examination requiring judgment and knowledge of anatomy. This includes the dissection of the specimen, selection of tissue, and any level of examination/description of the tissue including color, weight, measurement, or other characteristics of the tissue. The laboratory director may delegate the dissection of specimens to non-pathologist individuals; these individuals must be qualified as high complexity testing personnel under the CLIA regulations. The minimum training/experience required of such personnel is: Associate degree in a chemical or biological science, or medical laboratory technology from an accredited institution; OR . Education/training equivalent to the above that includes the following: 60 semester hours or equivalent from an accredited institution that, at a minimum includes 24 semester hours of medical laboratory technology courses, OR . 24 semester hours of science courses that include six semester hours of chemistry, 6 semester hours of biology, and 12 semester hours of chemistry, biology, or medical laboratory technology in any combination; AND . Laboratory training including either completion of a clinical laboratory training program approved or accredited by the ABHES, NAACLS, or other organization approved by HHS (this training may be included in the 60 semester hours listed above), OR . -
Forensic Pathology Large Coroner Offices Function Similar to a and the Type of Cases That Will Be Not Just for Popular TV Shows Medical Examiner Office
Victor Weedn forensic pathologists, and in some states, on coroners, who often lack training Health & Medicine ︱ coroners are appointed. Typically, a and need not heed the advice of the coroner is not a licensed physician and medical examiner. cannot perform an autopsy, so they act as medicolegal death investigators – HOW RELEVANT ARE but they retain the legal ability to sign MEDICOLEGAL DEATH the death certificate. All coroners are INVESTIGATIONS TODAY? county-based and most are rural. A few State statutes define the type of system Forensic pathology large coroner offices function similar to a and the type of cases that will be Not just for popular TV shows medical examiner office. investigated. Most deaths are natural and wikipedia.org/wiki/Charles_Norris_(medical_examiner) the patient’s doctor will certify the death Medical examiner’s offices are headed without the need for investigation, but Forensic pathology is one orensic pathology is not your implementation of collapsible steering by board-certified forensic pathologist deaths that are not under the care of a of the most exciting and average medical specialty. Made wheel columns. professionals. Forensic pathology requires physician often require a comprehensive fascinating specialties in all of Fpopular by crime scene investigation Charles Norris was the 1st Chief Medical Examiner more training and education than a family medicolegal death investigation for medicine. Dr Victor W. Weedn, TV shows over the decades, from Quincy, THE ORIGINS OF of the City of New York, in office 1918–1935. practitioner. Medical examiner offices may accurate designation of cause and Chief Medical Examiner for M.E. in the 1970s to Coroner in 2019, the FORENSIC PATHOLOGY be at city, county, regional, or state level. -
Necropsy Examination Often Is CHAPTER N Performed to Determine the Cause of an Unexpected Death
ecropsy examination of deceased patients should be an integral part of avian clinical medicine. Necropsy examination often is CHAPTER N performed to determine the cause of an unexpected death. However, a thorough and system- atic postmortem examination also may be used to confirm a clinical diagnosis, identify the etiology of a disease process, explain apparent unresponsiveness to treatment or reveal unrecognized disease proc- esses. Integration of necropsy findings with clinical signs and laboratory data ultimately will enhance 14 the clinician’s understanding of disease processes and sharpen clinical diagnostic skills. In addition, necropsy will confirm radiographic interpretations and reinforce applied anatomy, which enhances sur- gical skills. Necropsy examination is a relatively straightforward NECROPSY procedure that should follow a written protocol, XAMINATION thereby minimizing the possibility of overlooking im- E portant lesions. This chapter emphasizes the ne- cropsy of psittacine and passerine birds; anatomic variations of other avian species such as ratites may be found by consulting appropriate chapters in this textbook and published articles in the veterinary literature.3 Kenneth S. Latimer Maximum necropsy information can be obtained only Pauline M. Rakich by following a systematic approach and using ancil- lary support services as needed to establish a defini- tive diagnosis. Ancillary support services include his- topathology, clinical pathology, microbiology, parasitology and toxicology. 357 CHAPTER 14 NECROPSY EXAMINATION eral hundred kilograms for an ostrich.30 In the case of a small hummingbird, a dissection tray or board, Preparing for the Necropsy ophthalmic instruments and a magnifying loupe or dissecting microscope may be helpful. With large ratites, rib shears and a Stryker saw will be required.