FOURTHDUTCH ENDO-NP EURO- SYCHO MEETING

Golden Tulip Parkhotel 'Doorwerth', Doorwerth, 31 M a y - 3 J u n e 2 0 0 5 1 W E L C O M E

DEAR PARTICIPANT MEETING WEBSITE

The organizers proudly welcome you at the 4th Dutch The organization of the Endo-Neuro-Psycho Meeting Endo-Neuro-Psycho Meeting, the unique annual meeting has a permanent website on which past, present and for the Dutch endocrinologist and neuroscientist in the future information can be found. It also provides further broadest sense. This Endo-Neuro-Psycho Meeting 2005 information on how to apply as moderator for a session (ENP2005) is the 9th meeting of its kind, which started in at a future meeting. The site has the address 1997 as the 1st Dutch Endo-Neuro Meeting, but since http://www.enpmeeting.nl/enp. then has grown to the forum of national scientific The direct link to the pages of the present 2005 meeting exchange. A bit of its history and its success story can is http://www.enpmeeting.nl. be found on http://www.enpmeeting.nl/enp/history. Contact addresses One of the aims of the ENPmeeting is to present the most recent developments in clinical and pre-clinical research About this meeting in various fields of endocrinology and the Ms. Sonja van Eif neurosciences. The present program again offers many Secretariat Neurofederation exciting sessions in the fields of basal and clinical Josephine Nefkens Institute endocrinology, neuroendocrinology, neurosciences and P.O. Box 1738 behavioral neurosciences. To this end, many scientists, 3000 DR participating as moderators in the meeting, have e-mail [email protected] organized topic-oriented sessions in which both internationally well-known speakers were invited to About financial matters present their view on the future prospects as well as Dr. Freek L. van Muiswinkel junior scientists who will contribute with their latest Department of Neurology G03.228 results. This approach is chosen as to create an ideal University Medical Center Utrecht atmosphere that promotes interaction between junior P.O. Box 85500 investigators and established senior scientists, the 3508 GA Utrecht important second aim of the meeting. e-mail [email protected]

In addition poster sessions are organized that are open General information for both young and established scientists. We would like Dr. Gerard J. Boer to encourage everyone to actively attend these sessions. (board Dutch Neurofederation) Dept. Neuroregeneration The ENP2005 is again held in the Golden Tulip Parkhotel Netherlands Institute for Brain Research Doorwerth. The pleasant atmosphere of this conference Meibergdreef 33 site has proven to be very stimulating for scientific and 1105 AZ Amsterdam ZO social exchange in all previous meetings, and no doubt it e-mail [email protected] will do so in 2005. FUTURE MEETINGS AND CALL FOR PROPOSALS Finally, the organizers would like to stress and acknowledge the important contribution of the session The Dutch Endo-Neuro-Psycho Meeting will continue in moderators: they organized the sessions and together 2006, and again in the first week of June. Preliminary they are responsible for the exciting program of this dates for the next meeting are 6-9 June 2006. years meeting. In addition, the 4nd Dutch Endo-Neuro- Suggestions for sessions of the 2006 meeting can Psycho Meeting 2005 would not exist without the already be submitted. Announce your suggestions as generous financial support from our sponsors. moderator via the special form available in this booklet (see On behalf of the organizing committee, we wish you a page xxx), or use the electronic version on fruitful meeting in Doorwerth, http://www.ENPmeeting.nl/enp/ENP2006. All Dutch participants of Dutch Endo-Neuro-Psycho Hanno Pijl (chair Organizing committee) Meetings will receive an e-mail in September 2005 Sytze van Dam (chair Program committee reminding them about the possibility to organize a Endocrinology) session at the 5th Dutch Endo-Neuro-Psycho Meeting Bart Ellenbroek (chair Program committee 2006 / 10th Dutch Endo-Neuro Meeting 2006. Neuroscience) Detailed instructions for moderators will be published on Miranda van Turennout (chair Program committee the above mentioned web pages of the Endo-Neuro- Cognitive and behavioral neuroscience) Psycho Meeting. The e-mail address for correspondence is [email protected]. 2 ORGANIZATION/SPONSORS

ORGANIZING COMMITTEE PARTICIPATING ORGANIZATIONS

Gerard Boer (NIH, Amsterdam) vice-president Netherlands Federation of Neuroscience Organizations Gerard Borst (Erasmus MC, Rotterdam) (Neurofederation) Sytze van Dam (OLVG, Amsterdam) www.neurofederatie.nl Michaela Diamant (VUmc, Amsterdam) Netherlands Society for Endocrinology (NVE) (LU, Leiden) www.nve.nl Bart Ellenbroek (KUN, Nijmegen) Netherlands Society for Psychonomics (NVP) Richard Feelders (Erasmus MC, Rotterdam) nvp.nici.kun.nl Eric Fliers (AMC, UvA, Amsterdam) Dutch Society for Neuropsychology (NVN) Mechiel Korte (WUR, Wageningen) www.nvneuropsy.nl Freek van Muiswinkel (UMCU, Utrecht) treasurer Dutch-Belgian Society for Experimental and Clinical Albert Postma (UU, Utrecht) Neuroscience (EKN) Hanno Pijl (LUMC, Leiden) president www.ekn.org Wim Scheenen (KUN, Nijmegen) Wim Riedel (UM, Maastricht) SPONSORS Anton Scheurink (RUG, Groningen) Miranda van Turennout (KUN, Nijmegen) Organizations Mark Verheijen (VU, Amsterdam) committee secretariat Dutch Brain Foundation (HsN) Robbert Verkes (UMCN, Nijmegen) www.hsn.nl Ineke van der Zee (KUN, Nijmegen) Dutch League against Epilepsy Glucocorticoid hormone Programming in Early life and Program committee Endocrinology its impact on Adult Health (EUPEAH) Sytze van Dam (chair) www.eupeah.org Michaela Diamant Graduate School Neurosciences Amsterdam (ONWA) Richard Feelders www.onwa.med.vu.nl Eric Fliers Graduate School of Behavioral and Cognitive Mechiel Korte Neurosciences (BCN) Hanno Pijl www.bcn.rug.nl/bcn Anton Scheurink International Foundation Alzheimer Research (ISAO) www.alzheimer.nl Program committee Neuroscience Netherlands Institute for Brain Research Gerard Boer www.nih.knaw.nl Gerard Borst Netherlands Organization for Health Research and Bart Ellenbroek (chair) Development (ZonMw) Freek van Muiswinkel www.zonmw.nl Wim Scheenen NWO Foundation 'Aard- en Levenswetenschappen' Mark Verheijen (NWO-ALW) Ineke van der Zee www.nwo.nl/alw NWO Foundation 'Maatschappij en Program committee Cognitive & behavioral Gedragswetenschappen' (NWO-MaGW) neuroscience www.nwo.nl/magw Willem van der Does Albert Postma Companies Wim Riedel Elsevier Science B.V. (Amsterdam) Miranda van Turennout (chair) www.elsevier.com Robbert Verkes Ferring Pharmaceuticals (Hoofddorp) www.ferring.nl Secretariat registration Ipsen Farmaceutica BV (Hoofddorp) Sonja van Eif www.ipsen.com Novartis Pharma Oncology (Arnhem) Secretariat abstracts www.novartisoncology.nl Tini Eikelboom Novo Nordisk Farma B.V. (Alphen aan de Rijn) www.novonordisk.nl Pfizer BV (Capelle a/d IJssel) www.pfizer.nl Solvay Pharma B.V. (Weesp) www.solvay.com 3 INFORMATION

CONFERENCE SITE INSTRUCTIONS FOR ORAL PRESENTATIONS

Golden Tulip Parkhotel ‘Doorwerth’, Kabeljauwallee 35, Oral presentation time includes 10 min (long) or 5 min 6865 BL Doorwerth, tel. 0317 319010. discussion time (short presentations). The following lecture rooms are available: Branding Beamer equipment is available in all lecture rooms. The (plenary, parellel and poster sessions), Doorwerth, Patio moderator(s) of your session is (are) in charge of the and Gelderland (parallel sessions), and Renkum and computer part of the projection. A room assistant is Heelsum (satellite sessions). Sub 1 is the luggage room. available during each session for additional help. Sub 2 is a room with a PC for internet access, and the Please contact your session moderator, who now acts as room to connect your own laptop to the internet. Sub 3 is a chairperson, well in advance of the start of the session available as small meeting room for those who wish to to arrange swift change of files between the organize a small exchange meeting during the ENP2005 presentations. The organizers have suggested the (contact the registration desk). moderators to collect all presentation files on a single laptop. REGISTRATION DESK INSTRUCTIONS FOR POSTER PRESENTATIONS The registration desk is daily open till 13.00 h, and in the afternoon between 18.00-18.30 h (except Friday 3 June). Poster sessions are in the rear of lecture room Branding The desk provides you with lunch en dinner tickets and (Endo and Neuro 2 sessions) and at the corridor near the a program booklet if you have paid the necessary bar (Neuro 2 and Psycho sessions). Posters can be registration fee before the deadline of May 15. displayed on the day of the session and have to be The registration desk is also open for on site registration removed before 08.00 h the next day. Poster boards are and additional diner tickets. sized 100 x 120 cm. Posters can be mounted by drawing The hotel only serves drinks at the bar via bar tickets. pins, which will be available at the meeting. These tickects are available at the hotel desk. The Endocrinology session on Monday 2 June includes a lunch, all other sessions are combined with a coffee/tea INSTRUCTIONS FOR ACCOMMODATION break.

If accommodation is ordered, and your room will be in POSTER AWARDS Parkhotel Doorwerth, you can check-in at the hotel desk only after 14.00 h. Luggage should be stored in Sub 1, a For the Endocrinology, Neuroscience 1 and 2 and room available for luggage storage at all times. Hotel Cognitive and behavioral neuroscience poster sessions, accommodation includes breakfast that is served in the a poster will be awarded for presentation and quality. restaurant from 07.00 h onwards. Poster selection committees appointed by the three Check-out should be done before 13.00 h at the hotel scientific program committees will announce the winners desk. Any additional hotel service is at your own in Poster award ceremonies that will be held respectively expense. during the dinner of 31 May (Endocrinology), the dinner of 1 June (Neuroscience 1), following the INSTRUCTIONS FOR INVITED SPEAKERS FROM Neurofederation Lecture on 2 June ~16.50 h ABROAD (Neuroscience 2) and prior the NVN session on 'What it means to be human' on 3 June 16.00 h (Cognitive and Upon registration at the meeting desk, you will receive a behavioral neuroscience). travel reimbursement form in case you have been elected for payment of travel costs. Please fill out this form as requested and return it at the registration desk during the meeting or mail it to the treasurer within a month. If properly filled out and returned soon, you can count upon a swift bank transfer from the organization (within a month after submission). Note that the travel costs eligible for reimbursement are based on air fare APEX tourist class, 2nd class train fares and local taxi costs, and that the organizers need a copy of all your tickets. The address of the meeting treasurer: Dr. Freek L. van Muiswinkel, Dept.Neurology G03.228, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, e-mail [email protected].

4 T I M E / R O O M T A B L E

TUESDAY 31 MAY THURSDAY 2 JUNE

09.00 Registration (till 13.00 h) Entrance 08.00 Registration (till 13.00 h) Entrance 09.55 Opening Branding 08.30 Session 27 Doorwerth 10.00 NVE teaching session Branding Session 28 Patio 11.45 Session 2 Doorwerth Session 29 Gelderland Session 3 Patio Session 30 Branding Session 4 Branding 10.00 Posters Neuroscience 2 Session 5 Gelderland (incl. break) Branding 13.15 Posters Endocrinology (incl. lunch) Branding 12.00 EKN Keynote Lecture Branding 15.00 Session 6 Branding 12.45 Lunch Paviljon 16.00 Break 14.00 Session 32 Branding 16.30 Session 7 Doorwerth Session 33 Doorwerth Session 8 Branding Session 34 Patio Session 9 Gelderland Session 35 Gelderland Session 10 Patio *Satellite Neuropsychology 1 Heelsum 18.00 Registration (till 18.45 h) Entrance 15.30 Break 18.00 NVE Annual Member Meeting Doorwerth 16.00 Neurofederation Lecture Branding 19.00 Dinner Restaurant Poster Award Neuroscience 2 Poster Award Endocrinology *Satellite Neuropsychology 2 Heelsum 21.00 Organon Award Lecture Branding 17.00 Session 37 Doorwerth Session 38 Branding WEDNESDAY 1 JUNE Session 39 Patio Session 40 Gelderland 08.00 Registration (till 13.00 h) Entrance 18.00 Registration (till 18.45) Entrance 08.30 Session 12 Branding 19.00 Dinner Restaurant 09.00 *Satellite HUPO BPP 1 Heelsum 21.00 NVP Keynote Lecture Branding 09.30 Session 13 Doorwerth Session 14 Branding FRIDAY 3 JUNE Session 15 Patio Session 16 Gelderland 08.00 Registration (till 13.00 h) Entrance 10.00 *Satellite Neuroinformatics 1 Renkum 08.30 Session 42 Doorwerth 10.30 *Satellite HUPO BPP 2 Heelsum Session 43 Branding 11.00 Break Session 44 Gelderland 11.30 Marius Tausk Lecture Branding Session 45 Patio 12.15 Lunch Paviljon 10.00 Break 13.30 Session 18 Doorwerth 10.30 Session 46 Patio Session 19 Branding Session 47 Doorwerth Session 20 Patio Session 48 Branding Session 21 Gelderland Session 49 Gelderland *Satellite HUP BPP 3 Heelsum 12.00 Lunch Paviljon *Satellite Neuroinformatics 2 Renkum 13.00 Posters Cognition & Behavior Branding 15.00 Posters Neuroscience 1 14.30 Session 50 Patio (incl. break) Branding Session 51 Branding 15.20 *Satellite HUP BPP 4 Heelsum Session 52 Gelderland 17.00 Session 22 Branding Session 53 Doorwerth Session 23 Gelderland 16.00 Break Session 24 Patio 16.30 Poster Award Cogn. & Behavior Branding Session 25 Doorwerth NVN session 18.00 Registration (till 18.45 h) Entrance 18.00 Closure Branding 19.00 Dinner Restaurant Poster Award Neuroscience 1 21.00 'Hersenstichting' Lecture Branding

* Note that satellite sessions have a separate and independant time schedule

5 P L A N L E C T U R E R O O M S

LOCATION OF LECTURE ROOMS IN GOLDEN TULIP PARKHOTEL 'DOORWERTH'

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09.00 Registration (till 13.00) Session 4 (Branding) Mounting posters Endocrinology session GENETICS OF STRESS: ROLE OF CORTICOSTEROID RECEPTORS 09.55 OPENING (Branding) Moderators: Roel de Rijk and Erno Hanno Pijl (Leiden) Vreugdenhil (Leiden) 11.45 Stefan Wüst (Trier, Germany) 10.00 Session 1 (Branding) Association between common polymorphism in TEACHING SESSION NVE: THE METABOLIC the glucocorticoid receptor gene and HPA-axis SYNDROME responses to psychosocial stress Chairperson: Hans Romijn (Leiden) 12.15 Liesbeth van Rossum (Rotterdam) Achim Peters (Lübeck, Germany) Function of glucocorticoid receptor The selfish brain polymorphism Geert-Jan Biessels (Utrecht) 12.30 Roel de Rijk (Leiden) Insulin resistance, type 2 diabetes and cognitive Glucocorticoid and mineralocorticoid receptors function in the human stress response Hanno Pijl (Leiden) 12.45 Margien den Hollander-Gijsman (Leiden) Neuroendocrine features of obesity in humans A dimensional system to characterise the psychopathology of mood, anxiety and parallel sessions 2-5 somatoform disorders

Session 2 (Doorwerth) Session 5 (Gelderland) STRUCTURE-FUNCTION RELATIONS OF PSYCHIATRY AND THE METABOLIC GLYCOPROTEIN HORMONE RECEPTORS SYNDROME Moderators: Jan Bogerd (Utrecht) and Moderator: Johanna Assies (Amsterdam) Axel Themmen (Rotterdam) 11.45 Malcolm Peet (Sheffield, UK) 11.45 Sietse Mosselman (Oss) Diet and fatty acid metabolism in relation to Gonadotropins and their receptors: an overview schizophrenia and the metabolic syndrome 12.00 David Puett (Athens, GA, USA) 12.15 Anja Lok (Amsterdam) LH receptor structure and mode(s) of activation Obesity, fatty acids, homocysteine in recurrent 12.30 Djura Piersma (Rotterdam) depression Effects of a functional LH receptor variant on 12.30 Ieke Visser (Amsterdam) breast cancer survival The hypothalamic-pituitary-adrenal(HPA)-axis 12.45 Julia Oosterom (Oss) and fatty acids in recurrent depression Identification of low molecular weight ligands 12.45 Francois Pouwer (Amsterdam) for gonadotropin hormone receptors Depression, diabetes and fatty acids 13.00 Jan Bogerd (Utrecht) 13.00 Solrun Vidarsdottir (Leiden) Ligand-selective determinants and common Effects of antipsychotic drugs on glucose contact sites in LHR en FSHR metabolism

Session 3 (Patio) 13.15 POSTER SESSION ENDOCRINOLOGY OSTEOPOROSIS including lunch (Branding) Moderators: Paul Lips and Jenneke Klein Nulend (Amsterdam) 11.45 Lance Lanyon (London, UK) Mechanical stimulation of bone: interactions with hormones 12.15 Astrid Bakker (Leuven, Belgium) Mechanotransduction by bone cells 12.30 Christianne Reijnders (Amsterdam) Mechanical stimulation of rat bone: micro-array 12.45 Aviral Vatsa (London, UK) Bio-imaging of intracellular nitric oxide in single cells after mechanical loading 13.00 Esther Tanck (Nijmegen) Effects of mechanical stimulation on bone structure

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Session 6 (Branding) Session 9 (Gelderland) HOT TOPICS IN ENDOCRINOLOGY STRESS ENDOCRINOLOGY AND Chairperson: Anton Scheurink (Groningen) METABOLISM and Richard Feelders (Rotterdam) Moderator: Anton Scheurink (Groningen) 15.00 Gianluca Aimaretti (Turin, Italy) 16.30 Sietse de Boer (Groningen) Traumatic brain injury and hypopituitarism Neuroendocrinology of social stress (sponsored by Pfizer, Capelle a/d IJssel) 17.00 Marijke Laarakker (Utrecht) 15.30 Randall Sakai (Cincinnati, OH, USA) Isolation versus social stress: effects on Social stress, hormonal responses and energy experimental behavior balance 17.15 Annetrude de Mooij (Utrecht) (sponsored by Elsevier, Amsterdam) Behavioral analyses in genetic dissection of food exploration strategies 16.00 break 17.30 Angelique Heinsbroek (Groningen) Effect of prenatal stress on the development of parallel sessions 7-10 the metabolic syndrome 17.45 Yanina Revsin (Leiden) Session 7 (Doorwerth) HPA axis regulation in type 1 diabetic mice DIABETES AND FAT METABOLISM, LIPOPROTEIN REMNANTS Session 10 (Patio) Moderators: Marcel Twickler (Nijmegen) and BASAL AND CLINICAL ASPECTS OF Ton Maassen (Leiden) SOMATOSTATIN WITHIN THE ENDOCRINE 16.30 Pia Lundman (Stockholm, Sweden) SYSTEM Diabetes and vascular function Sponsored by Ipsen Farmaceutica BV, 17.00 Peter Voshol (Leiden) Hoofddorp The (patho)physiological role of apolipoproteins Moderators: Richard Feelders and Leo Hofland in lipid and glucose homeostasis (Rotterdam) 17.15 Aldo Grefhorst (Groningen) 16.30 Wouter de Herder (Rotterdam) Insulin sensitivity in animal models of hepatic Is there a role for novel somatostatin analogues steatosis in the treatment of neuroendocrine tumors? 17.30 Alexandra Mulder (Nijmegen) 17.00 Phillipe Jaquet (Marseille, France) Sympathetic nerve system and insulin Medical therapy of pituitary adenomas: chimeric resistance: the role of microcirculation compounds 17.45 Felix Kreier (Amsterdam) 17.15 Joost van der Hoek (Rotterdam) A hypothalamic network projecting to fat tissue; Potentials of the new somatostatin analogue role of the biological clock SOM 230 in the treatment of pituitary disorders 17.30 Virgil Dalm (Rotterdam) Session 8 (Branding) Somatostatin versus cortistatin in physiological PATHOPHYSIOLOGICAL IMPLICATIONS OF and pathological conditions POLYMORPHIC VARIATIONS IN ENDOCRINE GENES 18.00 NVE annual member meeting (Doorwerth) Moderator: Theo Visser (Rotterdam) 16.30 André Uitterlinden (Rotterdam) 19.00 dinner (Restaurant) Basic concepts and methodology; POSTER AWARD CEREMONY polymorphism in the vitamin D receptor ENDOCRINOLOGY 17.00 Erica van den Akker (Rotterdam) Polymorphisms in the cortisol receptor Session 11 (Branding) 17.15 Joyce van Meurs (Rotterdam) LECTURE ORGANON AWARD WINNER Polymorphisms in the estrogen receptor Chairperson: Aart-Jan van der Lelij 17.30 Joop Janssen (Rotterdam) (Rotterdam) Polymorphisms in the IGF-I gene 21.00 Winner to be announced at the meeting by 17.45 Robin Peeters (Rotterdam) Netherlands Society for Endocrinology (NVE) Polymorphisms in thyroid hormone-related genes

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1 14 Van der Laan S Remmers F Corepressor expression in rat brain Energy intake and expenditure after early postnatal food 2 restriction in rats Brinks V 15 Molecular and behavioural characterisation of male Patsouris D BALB/c and C57BL/6J mice PPARα governs glycerol metabolism 3 16 Meijer OC Korsheninnikova EV Identification of novel glucocortoid target genes in Hepatic insulin signalling and gene expression during different mouse tissue through genome wide screening time course of in vivo insulin stimulation for paired hormone response elements 17 4 Van den Hoek AM

Sarabdjitsingh RA PYY3-36 treatment ameliorates insulin resistance in The dynamic control of GR and MR by the ultradian C57BL6-mice on a high fat diet secretion of corticosteroids 18 5 Van den Hoek AM Mayer JL Both leptin deficiency and obese phenotype contribute Corticosterone-induced reduction in hippocampal to insulin resistance in ob/ob mice neurogenesis is reversed by short-term treatment with 19 the novel antidepressant RU486 (mifepristone) Heijboer AC 6 Inravenous administration of ghrelin differentially affects Dalm S hepatic and muscle insulin sensitivity The glucocorticoid antagonist mifepristone modifies 20 steroid signaling and coping styles in mice Reiling HW 7 The involvement of the LARS2 gene in Type 2 diabetes Morens C mellitus MCH stimulates food and water intake and participates 21 to the enhanced consumption of palatable food Kok P 8 Increased circadian prolactin release is blunted after Schmidt M body weight loss in obese premenopausal women Blockade of metabolic signals during maternal separation 22 suppresses a hypothalamic-pituitary-adrenal axis Kok P activation Short term bromocriptine treatment improves diurnal 9 glucose metabolism and enhances energy expenditure in Van Leeuwen N obese premenopausal women Single nucleotide polymorphisms (SNPs) in the MR gene 23 are associated with stress responsiveness Kok P 10 Spontaneous diurnal TSH secretion is enhanced in Mommersteeg PMC proportion to circulating leptin and is blunted after body Burnout is not reflected in deviant cortisol profiles or weight loss in obese premenopausal women feedback 24 11 Conemans EB Revsin Y The growth hormone/insulin-like growth factor-I axis and HPA axis regulation in Type 1 diabetes cognitive function in elderly men 12 25 Marsman A Visser JA Does prenatal stress influence the development of Ovarian follicle dynamics during the estrous cycle in insulin resistance? anti-Müllerian hormone-deficient mice 13 26 Wielinga PY Van de Heijning BJM Involvement of vagal afferents and meal-related signals Chronic leptin infusion advances but in hydroxycitric acid induced satiety immunoneutralization of leptin postpones puberty onset in female rats

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27 Ubink R Supplementation of estradiol increases the efficacy on bone of a new non-steroidal orally active androgen in orchidectomized rats 28 Rijntjes E Fetal/neonatal hypo- and hyperthyroidism affects Leydig and Sertoli cell development 29 Van Trotsenburg ASP The effect of thyroxine treatment started in the neonatal period on development and growth of two years old Down syndrome children: a randomized clinical trial

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08.00 Registration (till 13.00) Session 15 (Patio) Posters Neuroscience 1 session to be mounted CALCIUM AND EXOCYTOSIS Moderators: Remco Westerink and Session 12 (Branding) Matthijs Verhage (Amsterdam) ENDOCRINOLOGY KEYNOTE LECTURE 09.30 Ron Habets (Rotterdam) Chairperson: Sytze van Dam (Amsterdam) Residual calcium and plasticity of transmitter 08.30 Louis Gooren (Amsterdam) release Hormones and the brain, studies in transsexuals 09.45 Sander Groffen (Amsterdam) DOC2B and the art of vesicle pool maintenance: Separate and independant satellite schedule a molecular gearbox triggered by calcium HUPO BPP International Workshop on Mouse 10.00 Remco Westerink (Amsterdam) Models for Neurodegeneration Reduced vesicular catecholamine release in 09.00 Part 1 (Heelsum) calbindin-D28k null mutant mouse chromaffin cells parallel sessions 13-16 10.15 Guillermo Alvarez de Toledo (Sevilla, Spain) Exocytosis studied with high resolution patch Session 13 (Doorwerth) clamp capacitance, amperometric and GENDER, HORMONES AND BRAIN fluorescence measurements FUNCTION Moderators: Gert ter Horst (Groningen) and Session 16 (Gelderland) Mechiel Korte (Lelystad / Utrecht) NEUROTROPHINS: FROM THE CENTRAL 09.30 Inga Neumann (Regensburg, Germany) NERVOUS SYSTEM TO THE Brain neuropeptides: regulation of stress coping NEUROENDOCRINE CELL not only in the maternal brain Moderators: Wim Scheenen and Bruce Jenks 10.00 Zuoxin Wang (Tallahassee, FL, USA) (Nijmegen) Dopamine regulation of social attachment in a 09.30 Susana Cohen-Cory (Irvine, CA, USA) monogamous rodent Neurotrophin-induced plasticity in the 10.30 Cornelieke van de Beek (Amsterdam) developing CNS: from dendrites and axons to Prenatal influences of sex hormones on gender- synapses related behavior in infants 10.00 Thomas Dijkmans (Leiden) 10.45 Christel Westenbroek (Groningen) The effects of nerve growth factor (NGF) on Sex-specific effects of ‘social support’ in rats double-cortin-like kinase, a novel CamK-like after chronic stress kinase, in a PC12 cell model 10.15 Shridhara Chrakravarthy (Amsterdam) Session 14 (Branding) Cell autonomous inhibition of TrkB signalling IS EATING ALWAYS FUN? can induce dendritic pruning in the adult visual Moderators: Louk Vanderschuren and cortex Roger Adan (Utrecht) 10.30 Adhanet Kidane (Nijmegen) 09.30 Kenneth Carr (New York, NY, USA) Expression and function of p75 and TrkB Augmentation of drug reward by chronic food receptors in the pituitary melanotrope cell restriction: behavioral evidence and underlying 10.45 Dorien de Groot (Nijmegen) mechanisms Generation and analysis of Xenopus laevis with 10.00 Jacquelien Hillebrand (Utrecht) cell-specific transgene expression of (pro)BDNF Hypothalamic signaling in an animal model of anorexia nervosa Separate and independant satellite schedule 10.15 Donné Schmidt (Amsterdam) Neuroinformatics in the Netherlands Overlapping and segregating corticolimbic 10.00 Part 1 (Renkum) circuits involved in sucrose seeking and heroin seeking Separate and independant satellite schedule 10.30 Ramona Guerrieri (Maastricht) HUPO BPP International Workshop on Mouse The relationship between impulsivity and Models for Neurodegeneration feeding in humans 10.30 Part 2 (Heelsum) 10.45 Celine Morens (Groningen) Interactions between cholinergic systems and 11.00 break melanin concentrating hormone

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Session 17 (Branding) Session 20 (Patio) MARIUS TAUSK LECTURE GABA IN CIRCUITS Chairperson: Ron de Kloet (Leiden) (organized under auspices of the ‘SWO/Liga 11.30 Bruce McEwen (New York City, NY, USA) tegen Epilepsie’) Stress, sex and the hippocampus Moderators: Tineke van Rijn (Nijmegen) and Govert Hoogland (Maastricht) 12.15 lunch (Paviljon) 13.30 Arjen Brussaard (Amsterdam) GABAergic synapses: from receptors to parallel sessions 18-21 cognition 14.00 Maarten Kamermans (Amsterdam) Session 18 (Doorwerth) GABA, a neuromodulator in the retina NEURON-SCHWANN CELL INTERACTIONS 14.30 Gitte Bouwman (Nijmegen) IN HEALTH AND DISEASE GABA and absence epilepsy: corticothalamic Moderators: Dies Meijer (Rotterdam) and circuits Mark Verheijen (Amsterdam) 14.45 Lia Liefaard (Leiden)

13.30 Lawrence Wrabetz (Italy) Changes in GABAA receptor properties in the Protein quality control in the pathogenesis of post-SE model for temporal lobe epilepsy Charcot Marie Tooth 1B hereditary neuropathy 14.00 Martine Jaegle (Rotterdam) Session 21 (Gelderland) The Claw Paw gene and its role in peripheral DIABETES AND THE BRAIN nerve development Moderators: Suat Simsek (Amsterdam) and 14.15 Mark Verheijen (Amsterdam) Geert-Jan Biessels (Utrecht) Schwann cell SREBP-1 and associated lipid 13.30 Chris Ryan (Pittsburgh, PA, USA) metabolism are implicated in diabetic peripheral Cognitive (dys)function and diabetes neuropathy 14.00 Alette Wessels (Amsterdam) 14.30 Valeria Ramaglia (Amsterdam) Type 1 diabetes mellitus and cognitive The role of complement in Wallerian dysfunction: microangiopathy of the brain degeneration 14.15 Ineke Brands (Utrecht) 14.45 Martijn Tannemaat (Amsterdam) Brain MRI correlates of cognitive dysfunction in The effect of lentiviral vector-mediated delivery type 2 diabetes mellitus of neurotrophic factors on peripheral nerve 14.30 Peter de Jonge (Groningen) regeneration Depression and diabetes mellitus: what is the relationship? Session 19 (Branding) 14.45 Esther Pelgrim-Korf (Amsterdam) THE HPA AXIS IN INFLAMMATORY Relationship between diabetes mellitus and DISEASES hippocampal atrophy: the HAAS study Moderator: Inge Huitinga (Amsterdam) 13.30 Christoph Heesen (Hamburg, Germany) Separate and independant satellite schedule HPA-axis activity in multiple sclerosis, relation HUPO BPP International Workshop on Mouse with severity and cognition Models for Neurodegeneration 14.00 Bert Beishuizen (Amsterdam) 13.30 Part 3 (Heelsum) HPA-axis in severe critical illness 14.30 Lisa van Winsen (Amsterdam) Separate and independant satellite schedule Glucocorticoid receptor in multiple sclerosis Neuroinformatics in the Netherlands 14.45 Zeynel Erkut (Amsterdam) 13.30 Part 2 (Renkum) HPA-axis in multiple sclerosis; post mortem studies 15.00 POSTER SESSION NEUROSCIENCE 1 (Branding and Bar entrance area)

Separate and independant satellite schedule HUPO BPP International Workshop on Mouse Models for Neurodegeneration 15.20 Part 4 (Heelsum)

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parallel sessions 22-25 Session 25 (Doorwerth) IMAGING BIOLOGICAL PROCESSES WITH Session 22 (Branding) MRI NEURO-GLIA SIGNALING IN THE CNS Moderators: Erwin Blezer (Utrecht) and Moderator: Eric Boddeke (Groningen) Elga de Vries (Amsterdam) 17.00 Gorgio Carmignoto (Padova, Italy) 17.00 Mathias Hoehn (Köln, Germany) Astrocyte-mediated neuronal synchrony in the In vivo MR imaging of cells in brain: hippocampus methodological and physiological challenges 17.30 Alfonso Araque (Madrid, Spain) 17.30 Raoul Oude Engberink (Utrecht) Synaptic information processing by astrocytes Ex vivo labeling of monocytes for in vivo cell 18.00 Eiko de Jong (Groningen) tracking using MR imaging Neuron-glia communication in neuronal stress 17.45 Willem Mulder (Eindhoven) 18.15 Robert Hoek (Amsterdam) Lipid-based contrast agents for molecular and CD200-mediated regulation of microglia cellular MR imaging activation 18.00 Jeroen Geurts (Amsterdam) Grey matter involvement in multiple sclerosis: Session 23 (Gelderland) pathology and MRI SHORT-CUTS AND TRAFFIC JAMS: 18.15 Jet van der Zijden (Utrecht) PROTEIN TRANSPORT IN Mapping cortical projections after stroke using NEURODEGENERATION in vivo manganese enhanced MRI Moderator: Wiep Scheper (Amsterdam) 17.00 Casper Hoogenraad (Boston, MA, USA) 19.00 dinner (Restaurant) GRIP1 specifies dendrite morphogenesis by POSTER AWARD CEREMONY regulating receptor trafficking NEUROSCIENCE 1 17.30 Martijn Roelandse (Amsterdam) The role of synaptic vesicle release in 21.00 Session 26 (Branding) neurodegeneration and axon outgrowth HERSENSTICHTING LECTURE 17.45 Sidhartha Chafekar (Amsterdam) Chairperson: Marian Joëls (Amsterdam) Aβ trafficking and toxicity James McGaugh (Irvine, CA, USA) 18.00 Peter Peters (Amsterdam) Emotional arousal, memory consolidation and Intracellular trafficking of PrP the amygdala

Session 24 (Patio) IMPULSE ACTIVITY IN THE MIDBRAIN DOPAMINE SYSTEM AND THE VULNERABILITY TO DRUGS OF ABUSE Moderator: Geert Ramakers (Utrecht) 17.00 Michela Marinelli (Chicago, IL, USA) Electrophysiological correlates of addiction liability 17.45 Mischa de Rover (Amsterdam) Long term effects of changes in dopaminergic transmission on cholinergic modulation in the nucleus accumbens 18.00 Annelies Olijslager (Amsterdam) Serotonin’s potentiating interaction with dopamine neurons in SN and VTA areas of the rat 18.15 Daniel Mathon (Utrecht) Neurophysiological changes in the midbrain dopamine system of ì opioid receptor knockout mice

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1 14 Tiejesma B Cao C Regulation of energy balance by long-term Cognitive impairments indicative of striatal dysfunction overexpression of rAAV delivered npy in the in transgenic Huntington's disease rats mediodorsal hypothalamus 15 2 Cryns K Verhagen LAW Phenotypic characterization of the myo-inositol Involvement of serotonin and dopamine metabolism in monophosphatase 1 (IMPA1) deficient mice rats exposed to activity-based anorexia 16 3 Roman V La Fleur SE Sleep restriction by forced activity decreases Hepatic vagotomy alters limbic and hypothalamic hippocampal cell proliferation neuropeptide responses to insulin-dependent diabetes 17 and voluntary lard ingestion Meerlo P

4 Chronic sleep loss has long-lasting effects on 5-HT1a Groeneweg FL receptor sensitivity Effects of an hepatic vagotomy on the melanocortin 18 system and whole body energy metabolism in rats fed a Fronczek R high fat high sugar diet Basal metabolic rate and autonomic regulation at rest in 5 human narcolepsy Geerse GJ 19 The role of the melanocortin system in visceral pain Van Vliet SAM 6 Neuroprotective effects of Modafinil in a non-human De Lange RPJ primate Parkinson model Changes in NPY, CCK and substance P messenger RNA 20 expression in stress sensitised rats Ogan A 7 Alterations in the kinetic activity of aromatic-l-amino acid De Krom M decarboxylase and preliminary 2-de investigation of the Genotypic-phenotypic dissection of eating disorders brains in the 6-OHDA induced Parkinson’s disease model with a focus on neuropeptides of rat 8 21 Zhang H-Y Van Dam A-M Regulation of electric activity of Xenopus laevis Expression of interleukin-1 family genes in experimental melanotropes by brain-derived neurotrophic factor Parkinson’s disease: regional regulation of interleukin-1 9 action? Hendriks WTJ 22 Lentiviral vector-mediated gene transfer of BDNF, GDNF Dolga AM and NT-3 to the injured rat spinal cord Cytokines-mediated neuroprotective signaling pathways 10 in the central nervous system Bosman LWJ 23 TrkB-dependent climbing fiber elimination in the Knijff EM developing cerebellum The production of IL-1β and IL-6 by monocytes of 11 bipolar patients: effects of lithium Bruschettini M 24 A single course of antenatal betamethasone, growth Vallès A retardation, S100B protein, and cell proliferation within Chemokine and chemokine receptor expression after the brain and the lungs traumatic brain injury 12 25 Boelen E Koning N The susceptibility of various brain cells for Chlamydia The role of CD200-CD200 receptor interaction in the pneumoniae infection: an in vitro study regulation of microglia and macrophages in multiple 13 sclerosis Pudovkina OL 26 Effect of MK801 in global transient ischemia in gerbils Teunissen CE Specific oligodendrocyte damage in a three-dimensional brain spheroid culture system

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27 40 Dudok JJ Van Weering JRT Raphe nucleus organotypic slice culture to study the The role of Rb3a in chromaffin granule docking serotonergic connectivity ex vivo 41 28 De Kock CPJ Van der Meulen AAE Sparse coding in rat primary somatosensory (barrel) Migration of neural stem cells towards pathology in the cortex adult mouse brain 42 29 Rife M Lemmens EMP The role of FMRP in dendritic mRNA transport and Fate of newborn dentate granule cells after neonatal glutamatergic signalling in the brain seizures 43 30 Van Vliet EA Van Gemert NG Inhibition of the multidrug transporter P-glycoprotein by The effect of chronic stress on hippocampal calcium XR9576 improves seizure control in phenytoin-treated currents - reversal by RU38486? chronic epileptic rats 31 44 Middeldorp J Rijkers K Aâ expressed in the cytosol is efficiently degraded and Vagus nerve stimulation in the amygdala kindled rat does not inhibit the proteasome 45 32 Van Vught PWJ Phinney AL Identification of modifier genes that can delay ALS onset Elevated copper levels are associated with reduced ß- in a mouse model using genetic mapping and gene amyloid concentrations in vivo expression profiling 33 46 Hooijmans CR Vo TT Relationship between cholesterol, cerebrovascular The role of Semaphorin 3A in the disassembly of degeneration and β-amyloid deposition neuromuscular junctions in the G93A-hSOD1 mouse, a 34 model for amyotrophic lateral sclerosis Mulder M 47 Differential effects of 24(S)-hydroxycholesterol on the Teuling E expression of apolipoprotein E, the low density Neuron-specific expression of mutant SOD1 protein is lipoprotein receptor, HMGCoA-reductase and ABCG4 in sufficient to cause motor neuron disease in mice astrocytes and neurons 48 35 Korosi A Jansen PJ Response of the Edinger-Westphal urocortin 1 system to Apolpipoprotein E chaperones plant sterols in transport heterotypic chronic stress in the rat from blood to brain 49 36 Corstens GJH Wu YH Urocortin 1 stimulates Xenopus melanotrope cell A promoter polymorphism in the monoamine oxidase a functioning by activation of CRF receptor 1 gene modulates the susceptibility to monoamine oxidase 50 a dysfunction in Aleimer’s disease Calle M 37 Effect of starvation on cocaine-amphetamine related Wilhelmus MMM transcript, urocortin 1, corticotropin-releasing factor and Differential vascular expression of amyloid-beta met-enkephalin immunoreactivities in the brain and receptors and association with cerebral amyloid pituitary of Xenopus laevis angiopathy in Azheimer’s disease brains 51 38 Gounko NV Kap YS The effect of CRF and urocortin in GluRä2 expression Novel endoplasmic reticulum stress response targets in and its distribution in parallel fiber-Purkinje cell synapses Azheimer’s disease 52 39 De Wit S Scheper W Decreased estrogen receptor α expression in Upregulation of Rab6A in Azheimer’s disease is corticotrophin-releasing hormone neurons near active connected to endoplasmic reticulum stress hypothalamic MS lesions

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53 65 Bao AM Stam FJ Evidence of a direct androgenic involvement in the Finding transcription factors involved in activity of human corticotropin-releasing hormone neuroregeneration: a genomics approach neurons: an immunocytochemical and bandshift analysis 66 study Mac Gillavry HD 54 Transcriptional networks in neuronal regeneration Alfarez DN 67 The effects of short-term corticosterone incubation on De Bree FM dendritic morphology and spine density in hippocampal Gene expression profiling of the olfactory system CA1 neurons 68 55 Franssen EHP Roet KCD Gene expression profiling of the olfactory ensheathing The contribution of proteoglycans, Semaphorin3A and glia cell their possible interactions in neurite outgrowth 69 56 Bossers K De Wit J Gene expression profiling of Parkinson’s disease Fast axonal transport and targeting to growth cones and 70 filopodia of the secreted Semaphorin Sema3A in cortical Gilany K neurons Analysis of mouse hippocampal proteome by 57 multidimensional protein identification technology Vogelaar CF (MudPit) Intra-axonal mRNA expression in the peripheral nervous 71 system Gilany K 58 C-4 reversed-phase high-performance liquid Wierda KDB chromatography prefractionation prior to proteome PKC-dependent phosphorylation of Munc18-1 is analysis of N2A cell-line essential for short-term plasticity 72 59 Gilany K Toonen RF Proteome analysis of neuroblastoma cell line SH-SY5Y Evanescent wave microscopy reveals that Munc18-1 by GeLC-MS/MS and 2-DE organizes snare-dependent tethering of secretory 73 vesicles Schut D 60 Expression of two distinct tomosyn genes in the De Wit H mammalian brain Syntaxin 1 independent role for Munc18-1 in secretory 74 vesicle docking Counotte DC 61 Sexual reward causes transcriptional changes in the limbic Van den Oever MC system A proteomics approach to identify long-term molecular changes in the rat medial prefrontal cortex resulting from heroin and sucrose self-administration 62 Van Tijn P Partial proteasome inhibition by aberrant ubiquitin impairs learning and memory in transgenic mice 63 Schulenborg T Morbus Alzheimer - differential, quantitative proteome analysis and localisation of post-translational modifications in a transgenic mouse with endogenous proteasome inhibition 64 Schenk GJ The function of the DCLK gene in hippocampal plasticity

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08.00 Registration (until 13.00 h) Session 29 (Gelderland) Posters Neuroscience 2 session to be mounted MOLECULAR ASPECTS OF RECEPTOR AND CHANNEL FUNCTION Parallel sessions 27-30 Moderators: Henk Vijverberg (Utrecht) and Hans van Hooft (Amsterdam) Session 27 (Doorwerth) 08.30 David Colquhoun (London, UK) SEROTONIN SYSTEMS IN PSYCHIATRY Binding and gating at the single molecule: (organized under the auspices of the Dutch- studies with nicotinic and glycine receptors Belgian Society for Experimental and Clinical 09.15 Guus Smit (Amsterdam) Neurosciences EKN) Acetylcholine binding protein: a structural and Moderators: Thomas Cremers and functional model of the nicotinic receptor Bart Ellenbroek (Nijmegen) 09.30 Hans van Hooft (Amsterdam)

08.30 Mark Millan (Servier, France) Structure and function of serotonin 5-HT3 5-HT and the treatment of depression; a receptors in the CNS summary of available concepts/drugs and future 09.45 Chantal Smulders (Utrecht / Den Haag) perspectives for the novel exploitation of Subunit structure and function of nicotinic ACh serotonergic mechanisms receptors 09.00 Fokke Bosker (Groningen)

Physiological role of median raphe 5-HT1A Session 30 (Branding) autoreceptors NEUROGENESIS AND GLIOGENESIS IN 09.15 Herman Westenberg (Utrecht) CORTICAL DEVELOPMENT: MOLECULAR Overview of serotonin related clinical AND CELLULAR MECHANISMS developments in treatment of depression and Moderators: Paul Lucassen (Amsterdam) and anxiety Erno Vreugdenhil (Leiden) 09.30 Meg van Bogaert (Utrecht) 08.30 Stephen Noctor (San Francisco, CA, USA)

The 5-HT1A receptor mouse and anxiety Patterns of neuronal migration in the embryonic 09.45 Edwin Cuppen (Utrecht) cortex Functional characterization of the serotonin 09.00 Erno Vreugdenhil (Leiden) transporter knockout rat Doublecortin-like, a novel microtubule associated protein specifically expressed in Session 28 (Patio) radial glia and neuronal precursors, is crucial for BETWEEN THE EARS: NEURAL mitotic spindle stability MECHANISMS OF SOUND DECODING 09.15 Karin Boekhoorn (Amsterdam) Moderators: Gerard Borst (Rotterdam) and Expression of doublecortin and doublecortin-like Huib Versnel (Utrecht) in the embryonic nervous system 08.30 David Moore (Nottingham, UK) 09.30 Sharon Kolk (Utrecht) Auditory neuroscience: new frontiers ‘Ephective’ signalling: Eph and ephrins during 09.00 Adrian Rodriguez-Contreras (Rotterdam) cortical development A neuronal microcircuit in the barn owl auditory 09.45 Marco van Ham (Rotterdam) space map: implications for coding of binaural Microtubule dynamics and neuronal cues development 09.15 John van Opstal (Nijmegen) Role of the auditory midbrain in sound 10.00 POSTER SESSION NEUROSCIENCE 2 localization (Branding and Bar entrance area) 09.45 Nienke van Atteveldt (Maastricht) Cross-modal modulation of speech sound Session 31 (Branding) processing in the planum temporale EKN KEYNOTE LECTURE Chairperson: Bart Ellenbroek (Nijmegen) 12.00 Michel Ferrari (Leiden) Migraine, from patients to transgenic mice models, ..... and back

12.45 lunch (Paviljon)

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parallel sessions 32-35 Session 34 (Patio) VOLTAGE SENSITIVE DYES AS NEURONAL Session 32 (Branding) ACTIVITY INDICATORS HORMONES, PLASTICITY AND BEHAVIOR (sponsored by Graduate School Neuroscience Moderators: Paul Lucassen, Harm Krugers and Amsterdam ONWA) Marian Joëls (Amsterdam) Moderator: Wytse Wadman (Amsterdam) 14.00 Gal Richter Levin (Haifa, Israel) 14.00 Jian-Young Wu (Washington, DC, USA) Stress, cognition and plasticity Propagating waves in neocortical slices: an 14.30 Olof Wiegert (Amsterdam) optical imaging study Corticosterone hampers and facilitates synaptic 14.45 Bogden Milojkovic (Rotterdam) plasticity; the importance of timing Voltage-sensitive dye imaging of glutamate- 14.45 Danielle Champagne (Leiden / Amsterdam) evoked dendritic potentials in layer V pyramidal Maternal care and plasticity neurons 15.00 Marjolein Gerrits (Groningen) 15.00 Tim Heistek (Amsterdam) Cyclic estradiol treatment modulates the Voltage sensitive dye imaging of the mouse neurobiological responses to stress prefrontal cortex 15.15 Vera Brinks (Leiden) 15.15 Natalie Cappaert (Amsterdam) MR/GR interactions in cognition and emotion Stimulated and oscillatory activity in the hippocampal-entorhinal cortex slice Session 33 (Doorwerth) HOW TO SILENCE YOUR NERVES: Session 35 (Gelderland) APPLICATION OF SMALL INTERFERING THE NEUROMUSCULAR SYNAPSE: BASIC RNA AND CLINICAL ASPECTS Moderators: Simone Niclou (Amsterdam) and Moderators: Jan Verschuuren and Jaap Plomp Erno Vreugdenhil (Leiden) (Leiden) 14.00 Roderick Beijersbergen (Amsterdam) 14.00 Clarke Slater (Newcastle upon Tyne, UK) Large scale RNAi screens in mammalian cells as Current thoughts about the functional a tool to identify novel drug targets organization of the neuromuscular junction 14.30 Carlos Fitzsimons (Leiden) 14.30 Bart Jacobs (Rotterdam) Silencing genes in the living brain: application of Mechanisms of IVIg therapy in auto-immune small interference RNA neuromuscular disorders 15.00 Erich Ehlert (Amsterdam) 14.45 Mariska van der Plas (Leiden) Stimulating axonal regeneration through siRNA- Novel role of dystrophin at the drosophila mediated knock down of semaphorin receptors neuromuscular junction 15.15 Ronald van Kesteren (Amsterdam) 15.00 Mario Losen (Maastricht) Possibilities and impossibilities of dsRNA- The role of rapsyn in myasthenia gravis mediated knock-down of gene expression in 15.15 Ann de Haes (Groningen) cultured molluscan neurons Reversal of competitive neuromuscular block: a revolutionary approach

Satellite Netherlands Society for Neurophysiology 14.00 Part 1 (Heelsum) Cognition, behavior and emotion in adults with brain dysfunctions

15.30 break

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Session 36 (Branding) Session 39 (Patio) NEUROFEDERATION LECTURE 5-HT AND COGNITION Chairperson: Eric Boddeke (Groningen) Moderator: Arjan Blokland (Maastricht) 16.00 Helmut Kettenmann (, Germany) 17.00 Alfredo Meneses (Mexico City, Mexico) Mechanisms of neuron-glia interaction Overview of 5-HT receptor subtypes in learning and memory POSTER AWARD CEREMONY 17.30 Marleen Wingen (Maastricht) NEUROSCIENCE 2 Effects of serotonergic drugs on learning and memory in healthy volunteers Satellite Netherlands Society for 17.45 Martijn Meeter (Amsterdam) Neurophysiology Modelling memory functions of 5-HT 16.00 Part 2 (Heelsum) 18.15 Geoffrey van de Plasse (Amsterdam) Cognition, behavior and emotion in healthy Role of 5-HT in cognitive flexibility in rats children and children with brain dysfunctions Session 40 (Gelderland) parallel sessions 37-40 LIVING UNDER UNCERTAINTY: TOWARDS UNDERSTANDING THE FOUNDATIONS OF Session 37 (Doorwerth) HUMAN AND ANIMAL LONG-TERM CHOICE MECHANISM OF SYNAPTIC PLASTICITY BEHAVIOR Moderators: Nial Burnashev and Moderator: Ruud van den Bos and Christian Hansel (Rotterdam) Dennis Schutter (Utrecht) 17.00 Frances Edwards (London, UK) 17.00 Edward de Haan (Utrecht) LTP - a homeostatic mechanism to wipe the Overview neuropsychological processes of memory slate clean? decision making in humans in real-life and 17.30 Jonathan Jay Couey (Amsterdam) laboratory models Nicotine and the prefrontal cortex synaptic 17.30 Dennis Schutter (Utrecht) plasticity Psychopathology of decision making in humans 17.45 Marcel de Jeu (Rotterdam) 17.45 Henriëtte Prast (Amsterdam) Motor learning in LTD/LTP-deficient mice Decision making in behavioral finance 18.00 Wytse Wadman (Amsterdam) 18.00 Ruud van den Bos (Utrecht) Scaling neuronal excitability in response to non- Animal models of decision making specific synaptic activity 18.15 Matthijs Feenstra (Amsterdam) 18.15 Nail Burnashev (Amsterdam) Neurochemistry of decision making in rats LTP in mice with prolonged decay kinetics of NMDAR-mediated EPSCs 19.00 dinner (Restaurant)

Session 38 (Branding) Session 41 (Branding) NEUROGENOMICS: FROM MOLECULAR NVP KEYNOTE LECTURE ANATOMY TO BEHAVIORAL PHENOTYPE Chairperson: Jaap Murre (Amsterdam) (partially sponsored by EUPEAH) 21.00 Ian Robertson (Dublin, Ireland) Moderator: Nicole Datson (Leiden) title pending 17.00 Mark Vawter (Irvine, CA, USA) Postmortem gene expression studies in neuropsychiatric disorders 17.45 Maarten Morsink (Leiden) Generation of a molecular atlas of the hippocampus using laser microdissection and DNA microarrays 18.00 Yongjun Qin (Amsterdam) Gene expression changes in single dentate granule neurons after chronic unpredictable stress 18.15 Jonas Hauser (Zurich, Switzerland) Long-term neurobehavioral effects of prenatal dexamethasone in rats and marmosets

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1 13 Stienen PJ De Jong TR Fentanyl-induced depression of vertex-recorded, rather Effects of chronic treatment with fluvoxamine and than of primary somatosensory cortex-recorded, paroxetine during adolescence on 5-HT-related behavior somatosensory-evoked potentials, predict efficacy of in adult male rats analgesia as measured by fear-conditioned behaviour in 14 the rat Homberg JR 2 Phenotyping of the serotonin transporter knockout rat Stienen PJ 15 Development of a rat model using somatosensory- Govers R evoked potentials to predict efficacy of analgesia as The initial steps towards neuronal polarization measured by fear-conditioned behaviour 16 3 Heimel JA Jans L Functional imaging of the mouse visual system The effects of acute tryptophan depletion on affective 17 behaviour and cognition in male and female Wistar rats Jacobs EH 4 Real-time visualisation of circadian clock proteins in Van der Kam EL living suprachiasmatic nucleus slices Cocaine addiction: which factors play a role? 18 5 Houtman SH De Wilde MC Developmental expression and microtubule association Spatial memory impairment in beta-amyloid infused mice of EML4, a microtubule stabilizing protein 6 19 Caramaschi D Van der Hart MGC In vitro and in vivo recovery of different types of Pre- and postsynaptic 5-HT1a receptor functionality in mice selected for high and low aggression microdialysis membranes for neuropeptides and 7 “classical” neurotransmitters Natarajan D 20 Comparative analysis of the aggressive behavioral Van Hooijdonk LWA phenotypes in three artificially selected strains of mice Lentiviral-based manipulation of corticosteroid receptor 8 expression in the mouse brain: application of short Cornelisse LN interference RNA Somatodendritic release of 5-HT in the dorsal raphe 21 nucleus due to local NMDA receptor activity Kozicz T 9 Period 2 expression in urocortin 1 neurons in the rat Cornelisse LN Edinger-Westphal nucleus Chronic fluoxetine treatment reduces 5HT1a 22 autoreceptors in an animal model for depression Van Gassen KLI 10 Molecular characterization of epilepsy by microarray Jongsma ME analysis of gene expression in the human hippocampus Combining augmentation strategies in antidepressive 23 treatment - is augmentation of the citalopram induced Kaja S 5-HT response dependent on precursor availability? Neuromuscular synaptic characterization of a novel 11 CACNA1A knock-in mouse with the FHM1 S218L Rea K mutation The influence of alpha-1 receptors on citalopram-induced 24 increase of 5-HT levels in rat hippocampus Van Elburg RAJ 12 Transient microcircuit dynamics for the neocortex Wallinga AE 25 Long-lasting neurotoxic effect of dex-fenfluramine on the Van Aerde KI 5-HT system in the rat brain is modulated by ambient Gamma-band oscillations in rat prefrontal cortex temperature 26 Meredith RM Ation potential-induced calcium dynamics in dendrites and dendritic spines of prefrontal cortex layer 2/3 pyramidal neurons

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27 41 Min R Weenink RP Inhibition of spike timing-dependent plasticity induction Does adenovirus infect normal human brain tissue? by nonfibrillar ß-amyloid in layer 2/3 of the neocortex 42 28 Lutgens SI Krugers HJ Quantitative analysis of living cells in post-mortem In vivo regulatable expression of GFP tagged GluR1 human brain-samples in relation to neurotrophic factors subunits 43 29 Dubelaar EJG Holmgren C The human cholinergic, neurotrophic and metabolic Spike-timing-dependent plasticity at excitatory synapses response of degenerating neurons of Alzheimer’s disease onto layer 2/3 pyramidal cells within the prefrontal cortex patients, to neurotrophic growth factors in an in vitro 30 study Hojjati MR 44 H-Ras/ERK/synapsin I signalling modulates presynaptic Balesar RA plasticity and learning Electrical activity in post-mortem adult human brain 31 tissue cultures Van Woerden GM 45 The role of the H-Ras/ERK/synapsin I signalling Jacobs EH pathway in learning Cortical Cdk5, Munc18a and Mint1/x11á protein levels 32 are enhanced during the progression of Alzheimer’s Lubbers LJ disease: evidence for a neuroprotective mechanism?

Effects of 8-OHDPAT, a selective 5HT1a agonist, on 46 prepulse inhibition and telemetry in apomorphine- Özen H susceptible and apomorphine-unsusceptible rats Dissociation of motor and cognitive performance during 33 bilateral deep brain stimulation of the subthalamic Rutten K nucleus in a rat model of Parkinson disease Rolipram reverses scopolamine-induced and time 47 dependent forgetting in object recognition by different Niks EH mechanisms of action Strong association of myasthenia gravis with anti-musk 34 antibodies and HLA-DR14-DQ5: arguments for a distinct Boekhoorn K disease entity and pathogenesis Adult neurogenesis in relation to LTP and hippocampus 48 dependent memory in tau transgenic mice Titulaer MJ 35 Associated autoimmune diseases in patients with Veneman AJ myasthenia gravis or the Lambert-Eaton myasthenic Neural stem cell differentiation pattern after TSA syndrome and their families treatment 49 36 Van den Berge SA De Bruijn J Gene expression profiling of spinal motor neurons in a Transient co-expression of the transcription factors Olig1 mouse model of amyotrophic lateral sclerosis and Olig2 in neural stem cells 37 Mollon JV Effects of social conflicts on hippocampal neurogenesis in winning and losing rats 38 Van Eekelen JAM Embryonic expression of Scl is required for brain development 39 Van Donkelaar EL The effects of acute tryptophan depletion on BDNF protein levels in brain and serum of male and female rats 40 Wu L Rat neural precursor cells improve viability of neurons in co-cultured postmortem human brain tissue slice 21 P R O G R A M F r i d a y 3 J u n e (1)

08.00 Registration (until 13.00 h) Session 44 (Gelderland) Posters Cognitive and Behavioral Neuroscience COGNITIVE FUNCTION IN MDMA AND session to be mounted CANNABIS USERS DURING INTOXICATION AND ABSTINENCE Parallel sessions 42-45 Moderator: Jan Ramaekers (Maastricht) 08.30 Valerie Curran (London, UK) Session 42 (Doorwerth) Acute and residual neuropsychological effects ATTENTION AND WORKING MEMORY of MDMA Moderator: Chris Olivers (Amsterdam) 09.00 Gerry Jager (Utrecht) 08.30 Edward Awh (Eugene, OR, USA) Effects of chronic MDMA use on memory On the relationship between attention and processing: an fMRI study working memory 09.15 Cecile Henquet (Maastricht) 09.00 Steven Scholte (Amsterdam) Sensitivity to cannabis challenge in Scene segmentation during inattentional schizophrenic patients and recreational cannabis blindness users 09.15 Bernhard Hommel (Leiden) 09.30 Kim Kuypers (Maastricht) How the brain blinks: a binding account Decision making and impulsivity during acute 09.30 Sander Martens (Groningen) MDMA and alcohol intoxication To blink or not to blink: individual differences in 09.45 Peter van Ruitenbeek (Maastricht) the allocation of attention Decision making tasks during acute cannabis 09.45 Chris Olivers (Amsterdam) intoxication Attentional capture through memorized features Session 45 (Patio) Session 43 (Branding) SPEECH PERCEPTION IN RELATION TO NEUROACTIVE STEROIDS IN EMOTION SPEECH PRODUCTION DISORDERS AND STRESS Moderator: Lian Nijland (Nijmegen) (organized by the Section Biological 08.30 Frank Guenther (Boston, MA, USA) Psychiatry of the Dutch Society for Psychiatry) Auditory, somatosensory, and motor Moderators: Robert Verkes (Nijmegen) and interactions in speech acquisition and Jack van Honk (Utrecht) production 08.30 Torbjörn Bäckström (Umeå, Sweden) 09.00 Esther Janse (Utrecht) Basis of sex and stress hormone-induced CNS Lexical competition effects in speech perception symptoms and their treatment in aphasia 09.00 Jack van Honk (Utrecht) 09.15 Julia Klitsch (Groningen) Dynamic brain systems in quest for emotional Aphasic spoken language perception and homeostasis phonetic features 09.15 Frank van Broekhoven (Nijmegen) 09.30 Fred Hasselman (Nijmegen) Neuroactive steroids in mood and stress The auditory temporal processing deficit of regulation dyslexia 09.30 Erno Hermans (Utrecht) 09.45 Lian Nijland (Nijmegen)Auditory processing in Effects of testosterone on emotional processing children with speech/language output disorders 09.45 Guido van Wingen (Nijmegen) Effects of progesterone on emotional 10.00 break processing: an fMRI study

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parallel sessions 46-49 Session 48 (Branding) NEW DEVELOPMENTS IN SCHIZOPHRENIA Session 46 (Patio) RESEARCH OSCILLATORY BRAIN DYNAMICS DURING Moderator: Jeffrey Glennon (Weesp) COGNITIVE PROCESSES: THEORY, AND (partially sponsored by Solvay Pharma BV, APPLICATIONS RELATED TO LANGUAGE Weesp) PROCESSING 10.30 Trevor Robbins (Cambridge, UK) Moderator: Marcel Bastiaansen (Nijmegen) Cognitive impairment in schizophrenia: what do 10.30 Olivier Bertrand (Lyon, France) we see and what do we model? Local and large-scale oscillatory brain dynamics 11.00 Cathalijn Leenaars (Nijmegen / Weesp) in perception and cognition Altered thalamocortical transmission in animal 11.00 Kees Stam (Amsterdam) models of psychosis Spatial and temporal patterns of synchronous 11.15 Jamilja van der Meulen (Amsterdam) oscillations in EEG and MEG Contribution of prefrontal cortical dopamine and 11.15 Marcel Bastiaansen (Nijmegen) serotonin systems to cognitive flexibility Do you see what I mean? Theta power increases 11.30 Koen Grootens (Nijmegen) are involved in the retrieval of lexical semantic Cognitive dysfunction in patients with representations psychotic disorders 11.30 Tineke Snijders (Nijmegen) Oscillatory brain dynamics during sentence Session 49 (Gelderland) processing OBJECT CATEGORIES IN THE BRAIN 11.45 Jos van Berkum (Amsterdam) Moderator: Miranda van Turennout Can EEG oscillations help us track referential (Nijmegen) processes in language comprehension? 10.30 Alumit Ishai (Zurich, Switserland) Distributed representations of objects and faces Session 47 (Doorwerth) in the human brain THE EFFECTS OF STRESS HORMONES ON 11.00 Marieke van der Linden (Nijmegen) MEMORY FUNCTIONING Plasticity in the cortical representation of object Moderator: Bernet Elzinga (Leiden) categories 10.30 Oliver Wolf (Düsseldorf, Germany) 11.15 Romke Rouw (Amsterdam) Effects of cortisol or stress on memory retrieval Congenital prosopagnosia in humans 11.30 Ingrid Nieuwenhuis (Nijmegen) 11.15 Mattie Tops (Groningen) Consolidation of object-place associations in Cortisol and social affective memory declarative memory 11.30 Anda van Stegeren (Amsterdam) 11.45 Joyca Lacroix (Maastricht) Noradrenaline mediates amygdala activation in Predicting similarity ratings and recognition men and women during encoding of emotional rates for natural stimuli with the NIM model material 11.45 Bernet Elzinga (Leiden) 12.00 lunch (Paviljon) Working memory in stress-related disorders, an fMRI study 13.00 POSTER SESSION COGNITIVE AND BEHAVIORAL NEUROSCIENCE (Branding and Bar entrance area)

23 P R O G R A M F r i d a y 3 J u n e (3)

parallel sessions 50-53 Session 52 (Gelderland) MONOAMINES, COGNITION, AND Session 50 (Patio) SYMPTOMS COMBINING ANIMAL AND HUMAN GENETIC Moderator: Willem van der Does (Leiden) APPROACHES TO ATTENTION DISORDERS 14.30 Robert Rogers (Oxford, UK) Moderator: Eco de Geus (Amsterdam) The neuromodulation of emotional processing in 14.30 Eco de Geus (Amsterdam) risky social and non-social choice Introduction 15.15 Wendelien Merens (Leiden) 14.45 Maarten Loos (Amsterdam) Recognition of emotions and attentional bias Attention and expression profiling in inbred after low-dose and high-dose tryptophan mouse strains depletion in depression 15.00 Tommy Pattij (Amsterdam) 15.30 Lisbeth Evers (Maastricht) Studying the pharmacology of impulsivity in The effect of tryptophan depletion on brain rodents activation related to cognitive flexibility 15.15 Antonius Mulder (Amsterdam) 15.45 Linda Booij (Montreal, Canada / Leiden) Neuronal firing in the prefrontal cortex during Heart rate variability, serotonin function and learning and attention tasks in rodents impulsivity in remitted depressed patients with 15.30 Florencia Gosso (Amsterdam) and without a history of suicidal ideation A family-based candidate gene approach to human attention Session 53 (Doorwerth) 15.45 Eske Derks (Amsterdam) NUMBERS AND THE BRAIN Genetic and environmental determinants of Moderator: Aliette Lochy (Nijmegen) childhood attention problems 14.30 Wim Fias (Gent, Belgium) Representation of numbers in humans: a neural Session 51 (Branding) model THE COGNITIVE NEUROSCIENCE OF 15.00 Liane Kaufmann (Innsbruck, Austria) RESPONSE INHIBITION Number-size congruity effects in children and Moderator: Richard Ridderinkhof (Amsterdam) adults: a fMRI study 14.30 Marcel Brass (Leipzig, Germany) 15,15 Anja Ischebeck (Innsbruck, Austria) The inhibition of imitative response tendencies Complex arithmetic training: changes in cerebral 15.00 Evelijne Bekker (Utrecht) networks observed with fMRI Disentangling deficits in attention and inhibition 15.30 Bernie Caessens (Gent, Belgium) 15.15 Franc Donkers (Tilburg) A shared network for magnitude and order in the Inhibitory processes in an adapted go/nogo intra-parietal sulcus? paradigm 15.45 Jan Willem Koten (Maastricht) 15.30 Jennifer Ramautar (Amsterdam) Genetic load in activations related to number The effects of probability in the stop-signal processing: a twin study paradigm: an fMRI study 15.45 Wery van den Wildenberg (Marseille, France) 16.00 break What electrical and magnetic stimulation of the human brain tell us about the neural substrates of inhibitory control functions

24 P R O G R A M F r i d a y 3 J u n e (4)

16.30 POSTER AWARD CEREMONY COGNITIVE AND BEHAVIORAL NEUROSCIENCE

Session 54 (Branding) NVN SESSION ‘WHAT IT MEANS TO BE HUMAN’ (organized under auspices of the Dutch Society of Neuropsychology) Moderators: Albert Postma and Roy Kessels (Utrecht) 16.30 Hanspeter Mallot (Tubingen, Germany) How to find your way in the world: the neurocognition of spatial navigation (30) 17.00 Jaap Murre (Amsterdam / Maastricht) A lifetime of memories: acquisition, meaning, and loss (30) 17.30 Niels Schiller (Maastricht / Nijmegen) To speak and to misspeak - why do we make so few errors during speaking? (30)

18.00 CLOSURE

25 P S Y C H O P O S T E R S (1)

1 15 Van Heijnsbergen CCRJ Polderman JC The perception of emotion: electrophysiological The heritability of working memory speed and working evidence for rapid integration of facial and bodily memory capacity in children expression 16 2 Wassenberg R Cuppen L Development of time awareness in school-aged children Age-related effects on piecemeal processing of facial and the influence of sex, verbal ability, and parental expressions in autism education 3 17 Righart R Huizinga M Context influences early perceptual analysis of faces. An Developmental change in switching from color to shape, electrophysiological study and from stopping to going 4 18 Tamietto M Smulders SFA Automatic encoding of emotional body language in The crossover between automatic facilitation and spatial neglect and visual extinction subjective expectancy and the effect of practice 5 19 Nieuwland MS Van Ooyen A Testing the limits of the semantic illusion phenomenon: How attentional feedback guides learning of sensory ERPs reveal temporary semantic change deafness in representations discourse comprehension 20 6 Meeren HKM Otten M Dynamic activation in the visual network during early The influence of message-based predictability and lexical processing of biologically meaningful information: association on the discourse-dependent N400 effect evidence from magnetoencephalography using realistic 7 modeling Willems RM 21 When language meets action: the neural integration of Lindemann O gesture and speech Can action planning affect object perception? 8 22 Horemans I Janzen G Do we monitor the verbal outfit […uhm…] output of Effects of time and practice on the neural representation others? of navigationally relevant objects 9 23 Ganushchak L Jongsma MLA Effects of auditory distractors on verbal self-monitoring Knowing more then we know: the dynamics of implicit 10 learning revealed by single-trial ERP analyses Davidson DJ 24 ERP and joint time-frequency responses to grammatical Keus IM and semantic violations in Dutch-English bilinguals Psychophysiological evidence that the SNARC effect 11 has its functional locus in a response selection stage Christoffels IK 25 The neural correlates of verbal feedback: an fMRI study Browne K employing overt speech The interaction between motor fatigue and cognitive task 12 performance, an fMRI study Andics A 26 fMRI evidence on phonological categories in the brain Boersma G 13 Force measurements during index finger abduction Wagensveld B 27 Experience-dependent representations of phonological Lataster JJE codes during speaking: an fMRI study Visual information shows task specific interactions with 14 haptic performance in a delayed matching experiment Meijs CJC 28 Learning strategies in healthy children aged 6-12 years Van de Laar MC on a pictorial verbal learning test and the influence of The process of selective inhibitory control using the age and sex stop-signal task

26 P S Y C H O P O S T E R S (2)

29 43 Post M Knippenberg JMJ Reduced cortical activity in bilateral contractions: an Effects of anticipatory fear on the evoked potential from fMRI study the rat amygdala 30 44 Van der Veen W Van den Hove DLA Cortical activity during unilateral and bilateral Prenatal restraint stress and behavior; the implications of contractions in left-handed subjects a subsequent exposure to stress 31 45 Aarnoutse EJ Tolmacheva EA The sternberg paradigm in primates: effects of set size, Effects of acute stress on corticosterone and absence delay duration and automatization seizures in WAG/Rij rats 32 46 Croes E Kleefstra A Reaction time responding in rats: validation of a speed Reversal of phencyclidine stimulated basolateral accuracy tradeoff and information processing modeling amygdala dopamine and noradrenaline release by 33 aripiprazole but not clozapine, ziprasidone and Lansbergen MM haloperidol involves dopamine D2 and serotonin 5-HT1A ADHD and the Stroop interference effect: a meta- receptors analysis 47 34 Chan JSW Smit DJA Effects of 8-OH-DPAT and idazoxan on sexual behaviour Heritability of the full P3 in young adult and middle-aged in the endophenotypic, sluggish performing male Wistar subjects rat 35 48 Slabu LM Janssen MCW Imaging subcortical auditory activity in humans using Differential role of nucleus accumbens core and shell in fMRI amphetamine-induced impulsivity in rats 36 49 Broersen LM Gates AS Effects of dietary interventions in rat models of Cholinergic receptor regulation of phencyclidine depression stimulated mediodorsal thalamic glutamate levels. 37 influence of nicotinic receptors in the basolateral Van Wingen GA amygdala Acute effects of progesterone on emotion processing: an 50 fMRI study Böcker KBE 38 Nicotine influences motivational but not psychomotor Geerlings MI inhibition The joint effect of depressed mood and serum cortisol on 51 memory functioning in a community-based sample of Schellekens AFA middle aged and older men Apomorphine challenge in healthy volunteers, as 39 measured by growth hormone response, changes on an Diergaarde L ax-continuous performance task and acoustic startle Propranolol impairs memory reconsolidation in an response appetitive instrumental conditioning task 52 40 Roelofs K Stiedl O The effects of stress-induced cortisol on approach- Role of the dorsal hippocampus in emotional learning in avoidance action tendencies mice - strain-specific differential utilization 53 41 Van Luijtelaar G Lubbers ME Is sleep disturbed by absence seizures? MOR knockout mice in the morris water maze test: a 54 memory or motivation deficit? Wezenberg E 42 Drug-induced sedation in healthy volunteers: do Mol N lorazepam, mirtazapine, olanzapine and haloperidol show Startle potentiation in rapidly alternating conditions of different profiles on sedation measures? high and low predictability of threat

27 P S Y C H O P O S T E R S (3)

55 Wingen M Effects of depression and long-term antidepressant treatment on cognition and actual driving performance 56 Schmitt JAJ A review of the role of serotonin in human cognition 57 De Vries W A therapeutic role for methylphenidate in the treatment of alcohol addiction? 58 Biemans B Do antipsychotics differentially affect social interaction behaviours in a rat model for the negative symptoms of schizophrenia? 59 Bemelmans KJ Recall performance, plasma cortisol and plasma norepinephrine in Alzheimer’s disease 60 Ponsen MM Bimanual coordination dysfunction in early, untreated Parkinson’s disease 61 Van den Bergh FS Effects of social isolation on two types of impulsivity 62 Bannink M Psychiatric disorders in IFN-á treated oncology patients 63 Vossen HGM The influence of personality on cortical pain processing 64 Bouwens SFM Ecological validity of neuropsychological tests: what do they say about functioning in daily living?

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Wednesday 1 June Wednesday 1 June

Satellite HUPO BPP International Workshop Satellite Neuroinformatics in the Netherlands on Mouse Models for Neurodegeneration (Renkum) (Heelsum) 10.00 Wytse J. Wadman (Amsterdam) 09.00 Helmut E. Meyer (Bochum, Germany) Opening Welcome address & general update 09.10 David Fischer (Amsterdam) Chair: Wytse Wadman Proteomic changes in the cortex of a mouse 10.15 Bart M. ter Haar Romeny (Eindhoven) model with a chronic impaired proteasome Biologically inspired multi-scale image analysis activity 11.00 Ole Jensen (Nijmegen) 09.40 Eva-Maria Mandelkow (Hamburg, Germany) Measuring and modeling the human beta Role of tau protein in Alzheimer oscillations neurodegeneration 11.45 Rolf Kötter (Düsseldorf, Germany) Current challenges in the reconstruction of brain 10.10 break connectivity

10.30 Per Andrén (Uppsala, Sweden) 12.30 lunch Differential protein and neuropeptide expression in experimental Parkinson’s disease Chair: Jaap van Pelt (Amsterdam) 11.00 Ka Wan Li (Amsterdam) 13.30 Jos Roerdink (Groningen) Application of quantitative proteomics in Wavelet-based data analysis in functional MRI neurodegenerative diseases 14.15 Klaus Linkenkaer-Hansen (Amsterdam) 11.30 Martin Hrabé de Angelis (Neuherberg, Time series analysis: from hearts to brains Germany) The European Mouse Mutant Archive (EMMA) 15.00 Closure

12.00 lunch

13.30 Discussion: Select mouse models

15.00 break

15.20 Discussion: Select analysis strategy

S A T E L L I T E P R O G R A M (1)

29 S A T E L L I T E P R O G R A M (2)

Thursday 2 June

Satellite Netherlands Society for Neurophysiology (Heelsum)

14.00 Part 1 Cognition, behavior and emotion in adults with brain dysfunctions

IHGB Ramakers (Maastricht) Presentation of prodromes of dementia in general practice C Cao (Shanghai, China / Maastricht) Cognitive impairments indicative of striatal dysfunction in transgenic Huntington disease rats J van den Stock (Tilburg) Impaired recognition of facial expressions, instrumental, and emotional body actions in Huntington disease MJCM Magnee (Utrecht) Facial EMG and affect processing in autism

16.00 Part 2 Cognition, behavior and emotion in healthy children and children with brain dysfunctions

MA Boeschoten (Utrecht) Face processing in children with pervasive developmental disorder (PDD): the roles of expertise and spatial frequence KNJA van Braeckel (Groningen) Pointing behaviour in very preterm born children M van Handel (Utrecht) Long-term effects of neonatal encephalopathy on motor abilities, cognition, behavior and brain anatomy M Sprong (Utrecht) Neurocognitive functioning in adolescents with PDD-NOS, subtype multiple complex developmental disorder TJC Polderman (Amsterdam) The heritability of working memory speed and working memory capacity in children

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