Supplementary Materials Association of Preterm Birth with Depression and Particulate Matter: Machine Learning Analysis Using National Health Insurance Data
Average 1600.00
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0.00 Age Nitrate Region Prior Cone Prior GERD_2014 GERD_2013 GERD_2012 GERD_2011 GERD_2010 GERD_2009 Progesterone GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_07 PM_2014_01 PM_2014_06 PM_2014_12 PM_2014_08 PM_2014_10 PM_2014_11 PM_2014_09 PM_2014_05 PM_2014_02 PM_2014_04 PM_2014_03 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2010 Diabetes_2011 Diabetes_2009 Diabetes_2006 Diabetes_2005 Diabetes_2008 Diabetes_2007 Diabetes_2004 Diabetes_2003 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2009 Depression_2007 Depression_2008 Depression_2006 Depression_2005 Depression_2004 Depression_2003 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2014 Periodontitis_2009 Periodontitis_2013 Periodontitis_2010 Periodontitis_2008 Periodontitis_2002 Periodontitis_2011 Periodontitis_2003 Periodontitis_2007 Periodontitis_2004 Periodontitis_2012 Hypertension_2014 Hypertension_2013 Hypertension_2009 Hypertension_2008 Hypertension_2012 Hypertension_2006 Hypertension_2010 Hypertension_2011 Hypertension_2007 Hypertension_2005 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
PTB1 1400.00
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0.00 Age Nitrate Region Prior Cone Prior GERD_2014 GERD_2013 GERD_2012 GERD_2011 GERD_2010 GERD_2009 Progesterone GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_07 PM_2014_06 PM_2014_05 PM_2014_04 PM_2014_01 PM_2014_12 PM_2014_10 PM_2014_09 PM_2014_11 PM_2014_02 PM_2014_08 PM_2014_03 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2009 Diabetes_2010 Diabetes_2008 Diabetes_2006 Diabetes_2005 Diabetes_2011 Diabetes_2007 Diabetes_2003 Diabetes_2004 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2011 Depression_2012 Depression_2010 Depression_2009 Depression_2007 Depression_2006 Depression_2008 Depression_2005 Depression_2004 Depression_2003 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2009 Periodontitis_2008 Periodontitis_2013 Periodontitis_2003 Periodontitis_2004 Periodontitis_2007 Periodontitis_2014 Periodontitis_2002 Periodontitis_2010 Periodontitis_2012 Periodontitis_2011 Hypertension_2014 Hypertension_2013 Hypertension_2009 Hypertension_2010 Hypertension_2006 Hypertension_2012 Hypertension_2008 Hypertension_2007 Hypertension_2005 Hypertension_2011 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
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0.00 Age Nitrate Region Prior Cone Prior GERD_2014 GERD_2013 GERD_2012 GERD_2011 GERD_2010 GERD_2009 GERD_2008 Progesterone GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_08 PM_2014_12 PM_2014_02 PM_2014_11 PM_2014_09 PM_2014_06 PM_2014_10 PM_2014_01 PM_2014_07 PM_2014_05 PM_2014_03 PM_2014_04 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2011 Diabetes_2010 Diabetes_2006 Diabetes_2005 Diabetes_2009 Diabetes_2008 Diabetes_2004 Diabetes_2007 Diabetes_2003 Diabetes_2002 Benzodiazepine Depression_2014 Depression_2013 Depression_2012 Depression_2011 Depression_2008 Depression_2007 Depression_2010 Depression_2009 Depression_2006 Depression_2005 Depression_2002 Depression_2004 Depression_2003 Periodontitis_2006 Periodontitis_2002 Periodontitis_2014 Periodontitis_2011 Periodontitis_2013 Periodontitis_2003 Periodontitis_2010 Periodontitis_2007 Periodontitis_2008 Periodontitis_2004 Periodontitis_2005 Periodontitis_2012 Periodontitis_2009 Hypertension_2014 Hypertension_2013 Hypertension_2008 Hypertension_2012 Hypertension_2009 Hypertension_2011 Hypertension_2006 Hypertension_2010 Hypertension_2007 Hypertension_2005 Hypertension_2003 Hypertension_2002 Hypertension_2004 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
PTB3 1800.00 1600.00 1400.00 1200.00 1000.00 800.00 600.00 400.00 200.00 0.00 Age Nitrate Region Prior Cone Prior GERD_2013 GERD_2014 GERD_2012 GERD_2011 GERD_2010 GERD_2009 Progesterone GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_07 PM_2014_08 PM_2014_01 PM_2014_03 PM_2014_10 PM_2014_09 PM_2014_04 PM_2014_05 PM_2014_11 PM_2014_12 PM_2014_06 PM_2014_02 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2011 Diabetes_2010 Diabetes_2009 Diabetes_2005 Diabetes_2006 Diabetes_2008 Diabetes_2007 Diabetes_2004 Diabetes_2003 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2008 Depression_2009 Depression_2007 Depression_2006 Depression_2005 Depression_2004 Depression_2003 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2014 Periodontitis_2002 Periodontitis_2010 Periodontitis_2009 Periodontitis_2013 Periodontitis_2011 Periodontitis_2008 Periodontitis_2004 Periodontitis_2007 Periodontitis_2003 Periodontitis_2012 Hypertension_2014 Hypertension_2013 Hypertension_2008 Hypertension_2012 Hypertension_2006 Hypertension_2010 Hypertension_2009 Hypertension_2007 Hypertension_2011 Hypertension_2005 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
PTB4 1800.00 1600.00 1400.00 1200.00 1000.00 800.00 600.00 400.00 200.00 0.00 Age Nitrate Region Prior Cone Prior Progesterone GERD_2013 GERD_2014 GERD_2012 GERD_2011 GERD_2010 GERD_2009 GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_07 PM_2014_08 PM_2014_01 PM_2014_03 PM_2014_10 PM_2014_09 PM_2014_04 PM_2014_05 PM_2014_11 PM_2014_12 PM_2014_06 PM_2014_02 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2011 Diabetes_2010 Diabetes_2009 Diabetes_2005 Diabetes_2006 Diabetes_2008 Diabetes_2007 Diabetes_2004 Diabetes_2003 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2008 Depression_2009 Depression_2007 Depression_2006 Depression_2005 Depression_2004 Depression_2003 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2014 Periodontitis_2002 Periodontitis_2010 Periodontitis_2009 Periodontitis_2013 Periodontitis_2011 Periodontitis_2008 Periodontitis_2004 Periodontitis_2007 Periodontitis_2003 Periodontitis_2012 Hypertension_2014 Hypertension_2013 Hypertension_2008 Hypertension_2012 Hypertension_2006 Hypertension_2010 Hypertension_2009 Hypertension_2007 Hypertension_2011 Hypertension_2005 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
Figure S1. Random forest variable importance.
Average 1400.00 1200.00 1000.00 800.00 600.00 400.00 200.00 0.00 Age Nitrate Region Prior Cone Prior GERD_2014 GERD_2013 Progesterone GERD_2012 GERD_2011 GERD_2010 GERD_2009 GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_06 PM_2014_11 PM_2014_09 PM_2014_07 PM_2014_03 PM_2014_02 PM_2014_01 PM_2014_05 PM_2014_10 PM_2014_04 PM_2014_08 PM_2014_12 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2010 Diabetes_2011 Diabetes_2009 Diabetes_2005 Diabetes_2006 Diabetes_2008 Diabetes_2007 Diabetes_2004 Diabetes_2003 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2009 Depression_2008 Depression_2007 Depression_2006 Depression_2005 Depression_2004 Depression_2003 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2009 Periodontitis_2014 Periodontitis_2007 Periodontitis_2013 Periodontitis_2010 Periodontitis_2003 Periodontitis_2002 Periodontitis_2011 Periodontitis_2004 Periodontitis_2008 Periodontitis_2012 Hypertension_2014 Hypertension_2013 Hypertension_2012 Hypertension_2008 Hypertension_2010 Hypertension_2009 Hypertension_2006 Hypertension_2011 Hypertension_2007 Hypertension_2005 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium PTB1 1400.00
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0.00 Age Nitrate Region Prior Cone Prior GERD_2014 Progesterone GERD_2012 GERD_2013 GERD_2011 GERD_2010 GERD_2009 GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_07 PM_2014_11 PM_2014_02 PM_2014_06 PM_2014_01 PM_2014_08 PM_2014_10 PM_2014_09 PM_2014_03 PM_2014_05 PM_2014_12 PM_2014_04 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2010 Diabetes_2005 Diabetes_2006 Diabetes_2009 Diabetes_2011 Diabetes_2008 Diabetes_2007 Diabetes_2003 Diabetes_2004 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2009 Depression_2007 Depression_2008 Depression_2006 Depression_2005 Depression_2004 Depression_2002 Depression_2003 Periodontitis_2006 Periodontitis_2005 Periodontitis_2009 Periodontitis_2007 Periodontitis_2013 Periodontitis_2010 Periodontitis_2014 Periodontitis_2011 Periodontitis_2008 Periodontitis_2003 Periodontitis_2002 Periodontitis_2012 Periodontitis_2004 Hypertension_2014 Hypertension_2013 Hypertension_2008 Hypertension_2010 Hypertension_2006 Hypertension_2012 Hypertension_2009 Hypertension_2007 Hypertension_2011 Hypertension_2005 Hypertension_2003 Hypertension_2004 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium PTB2 700.00 600.00 500.00 400.00 300.00 200.00 100.00 0.00 Age Nitrate Region Prior Cone Prior Progesterone GERD_2014 GERD_2013 GERD_2012 GERD_2011 GERD_2010 GERD_2009 GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_09 PM_2014_03 PM_2014_05 PM_2014_06 PM_2014_11 PM_2014_02 PM_2014_12 PM_2014_04 PM_2014_08 PM_2014_07 PM_2014_01 PM_2014_10 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2011 Diabetes_2009 Diabetes_2008 Diabetes_2010 Diabetes_2005 Diabetes_2006 Diabetes_2003 Diabetes_2004 Diabetes_2007 Diabetes_2002 Benzodiazepine Depression_2014 Depression_2013 Depression_2012 Depression_2011 Depression_2010 Depression_2009 Depression_2008 Depression_2005 Depression_2007 Depression_2006 Depression_2003 Depression_2004 Depression_2002 Periodontitis_2006 Periodontitis_2003 Periodontitis_2002 Periodontitis_2009 Periodontitis_2010 Periodontitis_2011 Periodontitis_2013 Periodontitis_2005 Periodontitis_2008 Periodontitis_2014 Periodontitis_2007 Periodontitis_2012 Periodontitis_2004 Hypertension_2014 Hypertension_2013 Hypertension_2012 Hypertension_2009 Hypertension_2008 Hypertension_2011 Hypertension_2004 Hypertension_2010 Hypertension_2007 Hypertension_2005 Hypertension_2006 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
PTB3 1800.00 1600.00 1400.00 1200.00 1000.00 800.00 600.00 400.00 200.00 0.00 Age Nitrate Region Prior Cone Prior GERD_2014 GERD_2013 GERD_2012 Progesterone GERD_2011 GERD_2010 GERD_2009 GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_06 PM_2014_04 PM_2014_03 PM_2014_08 PM_2014_09 PM_2014_11 PM_2014_07 PM_2014_10 PM_2014_01 PM_2014_02 PM_2014_05 PM_2014_12 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2010 Diabetes_2011 Diabetes_2009 Diabetes_2005 Diabetes_2006 Diabetes_2007 Diabetes_2008 Diabetes_2003 Diabetes_2004 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2009 Depression_2007 Depression_2008 Depression_2006 Depression_2005 Depression_2003 Depression_2004 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2009 Periodontitis_2007 Periodontitis_2014 Periodontitis_2013 Periodontitis_2010 Periodontitis_2002 Periodontitis_2004 Periodontitis_2011 Periodontitis_2003 Periodontitis_2008 Periodontitis_2012 Hypertension_2014 Hypertension_2013 Hypertension_2012 Hypertension_2008 Hypertension_2010 Hypertension_2009 Hypertension_2006 Hypertension_2007 Hypertension_2011 Hypertension_2005 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
PTB4 1800.00 1600.00 1400.00 1200.00 1000.00 800.00 600.00 400.00 200.00 0.00 Age Nitrate Region Prior Cone Prior GERD_2014 GERD_2013 GERD_2012 Progesterone GERD_2011 GERD_2010 GERD_2009 GERD_2008 GERD_2007 GERD_2006 GERD_2005 GERD_2004 GERD_2003 GERD_2002 Myoma Uteri Myoma PM_2014_06 PM_2014_04 PM_2014_03 PM_2014_08 PM_2014_09 PM_2014_11 PM_2014_07 PM_2014_10 PM_2014_01 PM_2014_02 PM_2014_05 PM_2014_12 Sleeping Pills Sleeping Diabetes_2014 Diabetes_2013 Diabetes_2012 Diabetes_2010 Diabetes_2011 Diabetes_2009 Diabetes_2005 Diabetes_2006 Diabetes_2007 Diabetes_2008 Diabetes_2003 Diabetes_2004 Diabetes_2002 Benzodiazepine Depression_2013 Depression_2014 Depression_2012 Depression_2011 Depression_2010 Depression_2009 Depression_2007 Depression_2008 Depression_2006 Depression_2005 Depression_2003 Depression_2004 Depression_2002 Periodontitis_2006 Periodontitis_2005 Periodontitis_2009 Periodontitis_2007 Periodontitis_2014 Periodontitis_2013 Periodontitis_2010 Periodontitis_2002 Periodontitis_2004 Periodontitis_2011 Periodontitis_2003 Periodontitis_2008 Periodontitis_2012 Hypertension_2014 Hypertension_2013 Hypertension_2012 Hypertension_2008 Hypertension_2010 Hypertension_2009 Hypertension_2006 Hypertension_2007 Hypertension_2011 Hypertension_2005 Hypertension_2004 Hypertension_2003 Hypertension_2002 In Vitro Fertilization In Vitro Socioeconomic Status Socioeconomic Proton Pump Inhibitor Pump Proton Tricyclic Antidepressant Tricyclic Calcium Channel Blocker Channel Calcium
Figure S2. Random forest variable importance—undersampling.
Table S1. ICD-10 code for preterm birth, depression, gastroesophageal reflux disease and periodontitis.
Code Description O42.00 Onset of labor within 24 hours of rupture (0–33 weeks of gestation) O42.01 Onset of labor within 24 hours of rupture (34–36 weeks of gestation) O42.10 Onset of labor after 24 hours of rupture (0–33 weeks of gestation) O42.11 Onset of labor after 24 hours of rupture (34–36 weeks of gestation) PROM O42.20 Prolonged labor because of treatment (0–33 weeks of gestation) O42.21 Prolonged labor because of treatment (34–36 weeks of gestation) O42.90 Unspecified length of time between rupture and onset of labor (0–33 weeks of gestation) PTB O42.91 Unspecified length of time between rupture and onset of labor (34–36 weeks of gestation) O60.11 Preterm delivery with preterm labor (0–33 weeks of gestation) PTL O60.12 Preterm delivery with preterm labor (34–36 weeks of gestation) O60.19 Preterm delivery with preterm labor (unspecified weeks of gestation) O60.31 Preterm delivery without preterm labor (0–33 weeks of gestation) Other O60.32 Preterm delivery without preterm labor (34–36 weeks of gestation) O60.39 Preterm delivery without preterm labor (unspecified weeks of gestation) Depression F32 Depressive episode GERD K210 Gastroesophageal reflux disease with esophagitis K052 Aggressive periodontitis K0528 Other aggressive periodontitis K0529 Unspecified aggressive periodontitis Periodontitis K053 Chronic periodontitis K0538 Other chronic periodontitis K0539 Unspecified chronic periodontitis PTB Preterm Birth, PROM Premature Rupture of Membranes, PTL Preterm Labor with Preterm Delivery, GERD Gastroesophageal Reflux Disease.
Table S2. ATC code for medication.
Medication Code Description N05BA Benzodiazepine derivatives (N05 Psychoanaleptics, N05B Anxiolytics) Benzodiazepine N05CD Benzodiazepine derivatives (N05 Psychoanaleptics, N05C Hypnotics and sedatives) N05CF Benzodiazepine-related drugs (N05 Psychoanaleptics, N05C Hypnotics and sedatives) Calcium Channel Blocker C08 Calcium channel blockers Nitrate C01DA Organic nitrates Progesterone G03 Sex hormones and modulators of the genital system Proton Pump Inhibitor A02BC Proton pump inhibitors Sleeping Pills N05C Hypnotics and sedatives Tricyclic Antidepressant N06A Antidepressants